Method of treating or ameliorating metabolic disorders using GLP-1 receptor agonists conjugated to antagonists for gastric inhibitory peptide receptor (GIPR)

ABSTRACT

Methods of treating metabolic diseases and disorders using a composition comprising an antigen binding protein specific for the GIPR polypeptide conjugated to a GLP-1 receptor agonist are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the composition comprises an antibody or functional fragment thereof comprising a cysteine at one or more conjugation site(s) wherein the GLP-1 receptor agonist is conjugated to the antibody or functional fragment thereof through the side-chain of the cysteine residue.

CROSS REFERENCE TO RELATED APPLICATIONS

This patent application claims the benefit of U.S. provisional application No. 62/447,332, filed Jan. 17, 2017, which is herein incorporated by reference in its entirety.

FIELD OF THE INVENTION

The present disclosure relates to the treatment or amelioration of a metabolic disorder, such as type 2 diabetes, elevated glucose levels, elevated insulin levels, obesity, non-alcoholic fatty liver disease, cardiovascular diseases or diabetic nephropathy, using GLP-1 receptor agonists conjugated to an antigen binding protein specific for the gastric inhibitory peptide receptor (GIPR).

BACKGROUND OF THE INVENTION

Glucose-dependent insulinotropic polypeptide (GIP) is a single 42-amino acid peptide secreted from K-cells in the small intestine (duodenum and jejunum). Human GIP is derived from the processing of proGIP, a 153-amino acid precursor that is encoded by a gene localized to chromosome 17q (Inagaki et al., Mol Endocrinol 1989; 3:1014-1021; Fehmann et al. Endocr Rev. 1995; 16:390-410). GIP was formerly called gastric inhibitory polypeptide.

GIP secretion is induced by food ingestion. GIP has a number of physiological effects in tissues, including promotion of fat storage in adipocytes and promotion of pancreatic islet β-cell function and glucose-dependent insulin secretion. GIP and glucagon like polypeptide-1 (GLP-1) are known insulinotropic factors (“incretins”). Intact GIP is rapidly degraded by DPPIV to an inactive form. The insulinotropic effect of GIP is lost in type 2 diabetic patients while GLP-1's incretin effect remains intact (Nauck et al. J. Clinc. Invest. 1993; 91:301-307).

The GIP receptor (GIPR) is a member of the secretin-glucagon family of G-protein coupled receptors (GPCRs) having an extracellular N-terminus, seven transmembrane domains and an intracellular C-terminus. The N-terminal extracellular domains of this family of receptors are usually glycosylated and form the recognition and binding domain of the receptor. GIPR is highly expressed in a number of tissues, including the pancreas, gut, adipose tissue, heart, pituitary, adrenal cortex, and brain (Usdin et al., Endocrinology. 1993, 133:2861-2870). Human GIPR comprises 466 amino acids and is encoded by a gene located on chromosome 19q13.3 (Gremlich et al., Diabetes. 1995; 44:1202-8; Volz et al., FEBS Lett. 1995, 373:23-29). Studies have suggested that alternative mRNA splicing results in the production of GIP receptor variants of differing lengths in human, rat and mouse.

GIPR knockout mice (Gipr −/−) are resistant to high fat diet-induced weight gain and have improved insulin sensitivity and lipid profiles. (Yamada et al., Diabetes. 2006, 55:S86; Miyawaki et al. Nature Med. 2002, 8:738-742). In addition, a novel small molecule GIPR antagonist SKL-14959 prevents obesity and insulin resistance. (Diabetologia 2008, 51:S373, 44th EASD Annual meeting poster).

Collectively, these links to obesity and insulin resistance imply GIPR inhibition is a useful approach for therapeutic intervention.

Glucagon-like peptide-1 is a 31-amino acid peptide derived from the proglucagon gene. It is secreted by intestinal L-cells and released in response to food ingestion to induce insulin secretion from pancreatic β-cells (Diabetes 2004, 53:S3, 205-214). In addition to the incretin effects, GLP-1 also decreases glucagon secretion, delays gastric emptying and reduces caloric intake (Diabetes Care, 2003, 26(10): 2929-2940). GLP-1 exerts its effects by activation of the GLP-1 receptor, which belongs to a class B G-protein-coupled receptor (Endocrinology. 1993, 133(4):1907-10). The function of GLP-1 is limited by rapid degradation by the DPP-IV enzyme, resulting in a half-life of approximately 2 minutes. Recently, long-lasting GLP-1 receptor agonists (GLP-1 RAs) such as exenatide, liraglutide, dulaglutide have been developed and are now being used clinically to improve glycemic control in patients with type 2 diabetes. Furthermore, GLP-1RAs also promote body weight reduction as well as reduction in blood pressure and plasma cholesterol levels in patients (Bioorg. Med. Chem. Lett 2013, 23:4011-4018).

SUMMARY OF THE INVENTION

In one aspect, the present disclosure provides a method of treating a subject with a metabolic disorder, the method comprising administering to the subject a therapeutically effective amount of a composition comprising an antigen binding protein that specifically binds to human GIPR, wherein the antigen binding protein is conjugated to a GLP-1 receptor agonist. In one embodiment, the metabolic disorder is a disorder of glucose metabolism. In another embodiment, the glucose metabolism disorder comprises hyperglycemia and administering the antigen binding protein reduces plasma glucose. In another embodiment, the glucose metabolism disorder comprises hyperinsulinemia and administering the antigen binding protein reduces plasma insulin. In another embodiment, the glucose metabolism disorder comprises glucose intolerance and administering the antigen binding protein reduces increases glucose tolerance. In another embodiment, the glucose metabolism disorder comprises insulin resistance and administering the antigen binding protein reduces insulin resistance. In another embodiment, the glucose metabolism disorder comprises diabetes mellitus. In another embodiment, the subject is obese. In another embodiment, administering the composition reduces body weight in an obese subject. In another embodiment, administering the composition reduces body weight gain in an obese subject. In another embodiment, administering the composition reduces fat mass in an obese subject. In another embodiment, the glucose metabolism disorder comprises insulin resistance and administering the composition reduces insulin resistance in an obese subject. In another embodiment, administering the composition reduces liver steatosis in an obese subject having increased liver steatosis. In another embodiment, administering the composition reduces liver fat content in an obese subject having increased liver fat content.

In one aspect, the composition comprises an antibody or functional fragment thereof that specifically binds to a protein having an amino acid sequence having at least 90% amino acid sequence identity to an amino acid sequence of a human GIPR, wherein the antibody or functional fragment thereof comprises a cysteine or non-canonical amino acid amino acid substitution at one or more conjugation site(s) selected from the group consisting of D70 of the antibody light chain relative to reference sequence SEQ ID NO: 455; E276 of the antibody heavy chain relative to reference sequence SEQ ID NO: 612, and T363 of the antibody heavy chain relative to reference sequence SEQ ID NO: 612; and a GLP-1 receptor agonist, wherein the GLP-1 receptor agonist is conjugated to the antibody or functional fragment thereof through the side-chain of the cysteine residue or non-canonical amino acid residue substituted at the one or more conjugation site(s).

In one embodiment, the human GIPR has a sequence comprising a sequence selected from the group consisting of SEQ ID NO: 3141, SEQ ID NO: 3143, and SEQ ID NO: 3145. In one embodiment, the antibody or functional fragment thereof is a monoclonal antibody, a recombinant antibody, a human antibody, a humanized antibody, a chimeric antibody, a multispecific antibody, or an antibody fragment thereof. In one embodiment, the antibody fragment is a Fab fragment, a Fab′ fragment, or a F(ab′)2 fragment. In one embodiment, the antibody or functional fragment thereof is of the IgG1-, IgG2- IgG3- or IgG4-type. In one embodiment, the antibody or functional fragment thereof inhibits binding of GIP to the extracellular portion of human GIPR.

In one embodiment, the GLP-1 receptor agonist is GLP-1(7-37) or a GLP-1(7-37) analog. In one embodiment, the GLP-1 receptor agonist is selected from the group consisting of exenatide, liraglutide, lixisenatide, albiglutide, dulaglutide, semaglutide, and taspoglutide. In one embodiment, the GLP-1 receptor agonist is selected from the group consisting of GLP-1(7-37) (SEQ ID NO: 3184); GLP-1(7-36)-NH₂ (SEQ ID NO: 3185); liraglutide; albiglutide; taspoglutide: dulaglutide, semaglutide: LY2428757: Exendin-4 (SEQ ID NO: 3163); Exendin-3 (SEQ ID NO: 3164); Leu¹⁴-exendin-4 (SEQ ID NO: 3165); Leu¹⁴,Phe²⁵-exendin-4 (SEQ ID NO: 3166); Leu¹⁴,Ala¹⁹,Phe²⁵-exendin-4 (SEQ ID NO: 3167); exendin-4(1-30) (SEQ ID NO: 3168); Leu¹⁴-exendin-4 (1-30) (SEQ ID NO: 3169); Leu¹⁴,Phe²⁵-exendin-4(1-30) (SEQ ID NO: 3170); Leu¹⁴,Ala¹⁹,Phe²⁵-exendin-4 (1-30) (SEQ ID NO: 3171); exendin-4 (1-28) (SEQ ID NO: 3172); Leu¹⁴-exendin-4 (1-28) (SEQ ID NO: 3173); Leu¹⁴,Phe²⁵-exendin-4 (1-28) (SEQ ID NO: 3174); Leu¹⁴,Ala¹⁹,Phe²⁵-exendin-4 (1-28) (SEQ ID NO: 3175); Leu¹⁴,Lys^(17,20),Ala¹⁹,Glu²¹,Phe²⁵,Gln²⁸-exendin-4 (SEQ ID NO: 3176); Leu¹⁴,Lys^(17,20),Ala¹⁹,Glu²¹,Gln²⁸-exendin-4 (SEQ ID NO: 3177); octylGly¹⁴,Gln²⁸-exendin-4 (SEQ ID NO: 3178); Leu¹⁴,Gln²⁸,octylGly³⁴-exendin-4 (SEQ ID NO: 3179); Phe⁴,Leu¹⁴,Gln²⁸,Lys³³,Glu³⁴,Ile^(35,36),Ser³⁷-exendin-4(1-37) (SEQ ID NO: 3180); Phe⁴,Leu¹⁴,Lys^(17,20),Ala¹⁹ Glu²¹,Gln²⁸-exendin-4 (SEQ ID NO: 3181); Val¹¹,Ile¹³,Leu¹⁴,Ala¹⁶,Lys²¹,Phe²⁵-exendin-4 (SEQ ID NO: 3182), exendin-4-Lys⁴⁰ (SEQ ID NO: 3183); GLP-1(7-37) (SEQ ID NO: 3184); GLP-1(7-36)-NH₂ (SEQ ID NO: 3185); Aib^(8,35),Arg^(26,34),Phe³¹-GLP-1(7-36) (SEQ ID NO: 3186); HXaa₈EGTFTSDVSSYLEXaa₂₂Xaa₂₃AAKEFIXaa₃₀WLXaa₃₃Xaa₃₄G Xaa₃₆Xaa₃₇: wherein Xaa₈ is A, V, or G, Xaa₂₂ is G, K, or E; Xaa₂₃ is Q or K; Xaa₃₀ is A or E; Xaa₃₃ is V or K; Xaa₃₄ is K, N, or R; Xaa₃₆ is R or G; and Xaa₃₇ is G, H, P, or absent (SEQ ID NO: 3187); Arg³⁴-GLP-1(7-37) (SEQ ID NO: 3188); Glu³⁰-GLP-1(7-37) (SEQ ID NO: 3189); Lys²²-GLP-1(7-37) (SEQ ID NO: 3190); Gly^(8,36),Glu²²-GLP-1(7-37) (SEQ ID NO: 3191); Val⁸,Glu²²,Gly³⁶-GLP-1(7-37) (SEQ ID NO: 3192); Gly^(8,36),Glu²²,Lys³³,Asn³⁴-GLP-1(7-37) (SEQ ID NO: 3193); Val⁸,Glu²²,Lys³³,Asn³⁴Gly³⁶-GLP-1(7-37) (SEQ ID NO: 3194); Gly^(8,36),Glu²²,Pro³⁷-GLP-1(7-37) (SEQ ID NO: 3195); Val⁸,Glu²²,Gly³⁶,Pro³⁷-GLP-1(7-37) (SEQ ID NO: 3196); Gly^(8,36),Glu²²,Lys³³,Asn³⁴,Pro³⁷-GLP-1(7-37) (SEQ ID NO: 3197); Val⁸,Glu²²,Lys³³,Asn³⁴,Gly³⁶,Pro³⁷-GLP-1(7-37) (SEQ ID NO: 3198); Gly^(8,36),Glu²²-GLP-1(7-36) (SEQ ID NO: 3199); Val⁸,Glu²²,Gly³⁶-GLP-1(7-36) (SEQ ID NO: 3200); Val⁸,Glu²²,Asn³⁴,Gly³⁶-GLP-1(7-36) (SEQ ID NO: 3201); Gly^(8,36),Glu²²,Asn³⁴-GLP-1(7-36) (SEQ ID NO: 3202); GLP-1 analog (SEQ ID NO: 3206); GLP-1 analog (SEQ ID NO: 3207); [N^(e)-(17-carboxyheptadecanoic acid)Lys²⁰]exendin-4-NH₂ (SEQ ID NO: 3208); [N^(e)-(17-carboxyhepta-decanoyl)Lys³²]exendin-4-NH₂ (SEQ ID NO: 3209); [desamino-His¹,N^(e)-(17-carboxyheptadecanoyl)Lys²⁰]exendin-4-NH₂ (SEQ ID NO: 3210); [Arg^(12,27),NLe¹⁴,N^(e)-(17-carboxy-heptadecanoyl)Lys³²]exendin-4-NH₂ (SEQ ID NO: 3211); [N^(e)-(19-carboxy-nonadecanoylamino)Lys²⁰]-exendin-4-NH₂ (SEQ ID NO: 3212); [N^(e)-(15-carboxypentadecanoylamino)Lys²⁰]-exendin-4-NH₂ (SEQ ID NO: 3213); [N^(e)-(13-carboxytridecanoylamino)Lys²⁰]-exendin-4-NH₂ (SEQ ID NO: 3214); [N^(e)-(11-carboxy-undecanoyl-amino)Lys²⁰]exendin-4-NH₂ (SEQ ID NO: 3215); exendin-4-Lys⁴⁰(e-MPA)-NH₂ (SEQ ID NO: 3216); exendin-4-Lys⁴⁰(e-AEEA-AEEA-MPA)-NH₂ (SEQ ID NO: 3217); exendin-4-Lys⁴⁰(e-AEEA-MPA)-NH₂ (SEQ ID NO: 3218); exendin-4-Lys⁴⁰(e-MPA)-albumin (SEQ ID NO: 3219); exendin-4-Lys⁴⁰(e-AEEA-AEEA-MPA)-albumin (SEQ ID NO: 3220); exendin-4-Lys⁴⁰(e-AEEA-MPA)-albumin (SEQ ID NO: 3221); desamino-His⁷,Arg²⁶,Lys³⁴(N^(ε)-(γ-Glu(N-α-hexadecanoyl)))-GLP-1(7-37) (core peptide disclosed as SEQ ID NO: 3222) (SEQ ID NO: 3222); desamino-His⁷,Arg²⁶,Lys³⁴(N^(ε)-octanoyl)-GLP-1(7-37) (SEQ ID NO: 3223); Arg^(26,34),Lys³⁸(N^(ε)-(ω-carboxypentadecanoyl))-GLP-1(7-38) (SEQ ID NO: 3224); Arg^(26,34),Lys³⁶(N^(ε)-(γ-Glu(N-α-hexadecanoyl)))-GLP-1(7-36) (core peptide disclosed as SEQ ID NO: 3225) (SEQ ID NO: 3225); [Aib⁸;Lys³⁷]GLP-1 (7-37) (SEQ ID NO: 3226); [Aib⁸, Lys²⁶]GLP-1(7-37) (SEQ ID NO: 3227); [Aib^(8,22);Lys³⁶]GLP-1(7-36)-Amide (SEQ ID NO: 3228); [Aib^(8,22);BLeu³²;Lys³⁶]GLP-1(7-36)-Amide (SEQ ID NO: 3229); [Aib^(8,22);Lys³⁷]GLP-1(7-37)-Amide (SEQ ID NO: 3230); [Aib^(8,22);BLeu³²;Lys³⁷]GLP-1(7-37)-Amide (SEQ ID NO: 3231); [Aib^(8,22);aMeLeu³²;Lys³²]GLP-1(7-37)-Amide (SEQ ID NO: 3232); [Aib^(8,22);AMEF¹²;Lys³⁷]GLP-1(7-37)-Amide (SEQ ID NO: 3233); [Aib^(8,22);BLeu¹⁶;Lys³⁷]GLP-1(7-37)-Amide (SEQ ID NO: 3234); [Aib^(8,22);Gly³⁶;Lys³⁷]GLP-1(7-37)-Amide (SEQ ID NO: 3235); [Aib^(8,22);Lys^(33,37);Asn³⁴;Gly³⁶]GLP-1(7-37)-Amide (SEQ ID NO: 3236); [Aib^(8,22);Lys³³;Asn³⁴;Gly³⁶;Aeea³⁷]GLP-1(7-37)-Aeea-Lys-Amide (SEQ ID NO: 3237); [Aib^(8,22);Gly³⁶]GLP-1(7-37) (SEQ ID NO: 3238); cyclo[E²³-K²⁷][Aib⁸;Gly³⁶]GLP-1(7-37) (SEQ ID NO: 3239); cyclo[E²²-K²⁶][Aib⁸;Gly³⁶;Lys³⁷]GLP-1(7-37)-Amide (SEQ ID NO: 3240); [Aib^(8,22)]-GLP-1(7-22)-Ex4(17-39) (SEQ ID NO: 3241); [Gly^(8,36);Glu²²]GLP-1(7-37) (SEQ ID NO: 3242); [Aib⁸;Glu²²;Gly³⁶]GLP-1(7-37)-Amide (SEQ ID NO: 3243); [Aib⁸;Tyr¹⁶;Glu²²;Gly³⁶]GLP-1_(7-37) (SEQ ID NO: 3244); [Aib⁸;Lys^(18,33);Glu^(22,23,30);Val²⁵;Arg²⁶;Leu²⁷;Asn³⁴;Gly³⁶]GLP-1(7-37) (SEQ ID NO: 3245); [Aib⁸;Lys^(18,33);Glu^(22,23,30);Leu²⁷;Asn³⁴;Gly³⁶]GLP-1(7-37) (SEQ ID NO: 3246); [Aib⁸;Lys¹⁸;Glu^(22,23,30);Leu²⁷;Gly³⁶]GLP-1(7-37) (SEQ ID NO: 3247); [Aib^(8,22);Ile⁹;Gly³⁶]GLP-1_(7-36) (SEQ ID NO: 3248); and [Aib^(8,22);Glu¹⁵;Gly³⁶]GLP-1_(7-36) (SEQ ID NO: 3249).

In one embodiment, the GLP-1(7-37) or GLP-1(7-37) analog is conjugated to the antibody or fragment thereof at a residue that corresponds to K26, K36, K37, K39 or a C-terminal amine group of said analog.

In one embodiment, the GLP-1 receptor agonist if conjugated to the antibody or fragment thereof via a peptide linker comprising a sequence selected from the group consisting of (Gly₃Ser)₂, (Gly₄Ser)₂, (Gly₃Ser)₃, (Gly₄Ser)₃, (Gly₃Ser)₄, (Gly₄Ser)₄, (Gly₃Ser)₅, (Gly₄Ser)₅, (Gly₃Ser)₆, and (Gly₄Ser)₆.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1. Reaction scheme for the generation of anti-GIPR/GLP-1 peptide conjugate

FIGS. 2A-2T. GLP-1 receptor agonist activity in CHOK1-GLP-1R H20 recombinant cells and GIPR antagonist activity in 293 HEK-GIPR #10 recombinant cells

FIGS. 3A-3C. GLP-1 agonist activity of 2G10 conjugate is more potent in cells expressing both GLP-1R and GIPR (CHOK1 hGLP-1R/hGIPR M1) compared to cells only expressing GLP-1R (CHOK1 hGLP-1R H20)

FIGS. 4A-4R. In vivo activity—glucose and body weight effects in db/db mice

FIGS. 5A-5D. GLP-1 receptor agonist and GIPR Antagonist In vivo Activity of 5G12 and 2G10 Chemical Conjugates in C57Bl6 mice (glucose tolerance test)

FIGS. 6A-6B. GLP-1 receptor agonist and GIPR Antagonist In vivo Activity of 5G12 and 2G10 Chemical Conjugates in DIO mice (plasma glucose and change in body weight)

FIG. 7. GLP-1R-GIPR bispecific conjugate 1273 reduces body weight in male spontaneously obese cynomolgus monkeys (% change from baseline)

FIG. 8. GLP-1R-GIPR bispecific conjugate 1273 reduces total energy intake in male spontaneously obese cynomolgus monkeys (% change from baseline)

FIG. 9. GLP-1R-GIPR bispecific conjugate 1273 reduces fasting insulin in male spontaneously obese cynomolgus monkeys (% change from baseline)

FIG. 10. GLP-1R-GIPR bispecific conjugate 1273 reduces fasting triglycerides in male spontaneously obese cynomolgus monkeys (% change from baseline)

FIG. 11. GLP-1R-GIPR bispecific conjugate 1273 reduces fasting total cholesterol in male spontaneously obese cynomolgus monkeys (% change from baseline)

FIG. 12. GLP-1R-GIPR bispecific conjugate 1264 reduces body weight in male spontaneously obese cynomolgus monkeys (% change from baseline)

FIG. 13. GLP-1R-GIPR bispecific conjugate 1264 reduces total energy intake in male spontaneously obese cynomolgus monkeys (% change from baseline)

FIG. 14. GLP-1R-GIPR bispecific conjugate 1264 reduces fasting insulin in male spontaneously obese cynomolgus monkeys (% change from baseline)

FIG. 15. GLP-1R-GIPR bispecific conjugate 1264 reduces fasting triglycerides in male spontaneously obese cynomolgus monkeys (% change from baseline)

FIG. 16. GLP-1R-GIPR bispecific conjugate 1264 reduces fasting total cholesterol in male spontaneously obese cynomolgus monkeys (% change from baseline)

FIG. 17. GLP-1R-GIPR bispecific conjugates 1248 and 1257 reduce body weight in male spontaneously obese cynomolgus monkeys (% change from baseline)

FIG. 18. GLP-1R-GIPR bispecific conjugates 1248 and 1257 reduce total energy intake in male spontaneously obese cynomolgus monkeys (% change from baseline)

FIG. 19. GLP-1R-GIPR bispecific conjugates 1248 and 1257 reduce fasting insulin in male spontaneously obese cynomolgus monkeys (% change from baseline)

FIG. 20. GLP-1R-GIPR bispecific conjugates 1248 and 1257 reduce fasting triglycerides in male spontaneously obese cynomolgus monkeys (% change from baseline)

FIG. 21. GLP-1R-GIPR bispecific conjugates 1248 and 1257 reduce fasting cholesterol in male spontaneously obese cynomolgus monkeys (% change from baseline)

FIGS. 22A-22B. Binding affinity of anti-GIPR/GLP-1R bispecific conjugates

FIG. 23. Anti-GIPR/GLP-1R bispecific conjugate 1248 promotes strong GLP-1R and GIPR internalization in cells expressing both GLP-1R and GIPR

FIGS. 24A-24B. Time course and dose response of anti-GIPR/GLP-1R bispecific conjugates in GLP-1R internalization assay

FIGS. 25A-25D. GLP-1R, GIPR and bispecific conjugate are co-localized upon internalization

FIGS. 26A-26B. Inhibition of receptor internalization reduces 1248-induced cAMP generation

FIGS. 27A-27C. Bispecific conjugates show binding to GLP-1R and GIPR in FACS analysis

FIG. 28. Anti-GIPR/GLP-1R bispecific conjugates stimulate calcium flux

FIGS. 29A-29B. Anti-GIPR/GLP-1R bispecific conjugate 1248 promotes beta-arrestin recruitments through both GLP-1R and GIPR pathways

FIG. 30. Anti-GIPR/GLP-1R bispecific conjugate 1248 stimulates insulin secretion in human pancreatic microislets

DETAILED DESCRIPTION OF THE INVENTION

The present disclosure provides a method of treating a metabolic disorder, such as a disorder of glucose metabolism (e.g. Type 2 diabetes, elevated glucose levels, elevated insulin levels, dyslipidemia, metabolic syndrome (Syndrome X or insulin resistance syndrome), glucosuria, metabolic acidosis, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic cardiomyopathy, Type 1 diabetes, obesity and conditions exacerbated by obesity) by blocking or interfering with the biological activity of GIP. In one embodiment, a therapeutically effective amount of an isolated human GIPR binding protein conjugated to a GLP-1 receptor agonist is administered to a subject in need thereof. Methods of administration and delivery are also provided.

Recombinant polypeptide and nucleic acid methods used herein, including in the Examples, are generally those set forth in Sambrook et al., Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Laboratory Press, 1989) or Current Protocols in Molecular Biology (Ausubel et al., eds., Green Publishers Inc. and Wiley and Sons 1994), both of which are incorporated herein by reference for any purpose.

The section headings used herein are for organizational purposes only and are not to be construed as limiting the subject matter described.

Unless otherwise defined herein, scientific and technical terms used in connection with the present application shall have the meanings that are commonly understood by those of ordinary skill in the art. Further, unless otherwise required by context, singular terms shall include pluralities and plural terms shall include the singular.

Generally, nomenclatures used in connection with, and techniques of, cell and tissue culture, molecular biology, immunology, microbiology, genetics and protein and nucleic acid chemistry and hybridization described herein are those well known and commonly used in the art. The methods and techniques of the present application are generally performed according to conventional methods well known in the art and as described in various general and more specific references that are cited and discussed throughout the present specification unless otherwise indicated. See, e.g., Sambrook et al., Molecular Cloning: A Laboratory Manual, 3rd ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y. (2001), Ausubel et al., Current Protocols in Molecular Biology, Greene Publishing Associates (1992), and Harlow and Lane Antibodies: A Laboratory Manual Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y. (1990), which are incorporated herein by reference. Enzymatic reactions and purification techniques are performed according to manufacturer's specifications, as commonly accomplished in the art or as described herein. The terminology used in connection with, and the laboratory procedures and techniques of, analytical chemistry, synthetic organic chemistry, and medicinal and pharmaceutical chemistry described herein are those well-known and commonly used in the art. Standard techniques can be used for chemical syntheses, chemical analyses, pharmaceutical preparation, formulation, and delivery, and treatment of patients.

It should be understood that this invention is not limited to the particular methodology, protocols, and reagents, etc., described herein and as such may vary. The terminology used herein is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the disclosed, which is defined solely by the claims.

Other than in the operating examples, or where otherwise indicated, all numbers expressing quantities of ingredients or reaction conditions used herein should be understood as modified in all instances by the term “about.” The term “about” when used in connection with percentages may mean±1%.

Following convention, as used herein “a” and “an” mean “one or more” unless specifically indicated otherwise.

As used herein, the terms “amino acid” and “residue” are interchangeable and, when used in the context of a peptide or polypeptide, refer to both naturally occurring and synthetic amino acids, as well as amino acid analogs, amino acid mimetics and non-naturally occurring amino acids that are chemically similar to the naturally occurring amino acids.

A “naturally occurring amino acid” is an amino acid that is encoded by the genetic code, as well as those amino acids that are encoded by the genetic code that are modified after synthesis, e.g., hydroxyproline, γ-carboxyglutamate, and O-phosphoserine. An amino acid analog is a compound that has the same basic chemical structure as a naturally occurring amino acid, i.e., an a carbon that is bound to a hydrogen, a carboxyl group, an amino group, and an R group, e.g., homoserine, norleucine, methionine sulfoxide, methionine methyl sulfonium. Such analogs can have modified R groups (e.g., norleucine) or modified peptide backbones, but will retain the same basic chemical structure as a naturally occurring amino acid.

An “amino acid mimetic” is a chemical compound that has a structure that is different from the general chemical structure of an amino acid, but that functions in a manner similar to a naturally occurring amino acid. Examples include a methacryloyl or acryloyl derivative of an amide, β-, γ-, δ-imino acids (such as piperidine-4-carboxylic acid) and the like.

A “non-naturally occurring amino acid” is a compound that has the same basic chemical structure as a naturally occurring amino acid, but is not incorporated into a growing polypeptide chain by the translation complex. “Non-naturally occurring amino acid” also includes, but is not limited to, amino acids that occur by modification (e.g., posttranslational modifications) of a naturally encoded amino acid (including but not limited to, the 20 common amino acids) but are not themselves naturally incorporated into a growing polypeptide chain by the translation complex. A non-limiting lists of examples of non-naturally occurring amino acids that can be inserted into a polypeptide sequence or substituted for a wild-type residue in polypeptide sequence include β-amino acids, homoamino acids, cyclic amino acids and amino acids with derivatized side chains. Examples include (in the L-form or D-form; abbreviated as in parentheses): citrulline (Cit), homocitrulline (hCit), Nα-methylcitrulline (NMeCit), Nα-methylhomocitrulline (Nα-MeHoCit), ornithine (Orn), Nα-Methylornithine (Nα-MeOrn or NMeOrn), sarcosine (Sar), homolysine (hLys or hK), homoarginine (hArg or hR), homoglutamine (hQ), Nα-methylarginine (NMeR), Nα-methylleucine (Nα-MeL or NMeL), N-methylhomolysine (NMeHoK), Nα-methylglutamine (NMeQ), norleucine (Nle), norvaline (Nva), 1,2,3,4-tetrahydroisoquinoline (Tic), Octahydroindole-2-carboxylic acid (Oic), 3-(1-naphthyl)alanine (1-Nal), 3-(2-naphthyl)alanine (2-Nal), 1,2,3,4-tetrahydroisoquinoline (Tic), 2-indanylglycine (IgI), para-iodophenylalanine (pI-Phe), para-aminophenylalanine (4AmP or 4-Amino-Phe), 4-guanidino phenylalanine (Guf), glycyllysine (abbreviated “K(Nε-glycyl)” or “K(glycyl)” or “K(gly)”), nitrophenylalanine (nitrophe), aminophenylalanine (aminophe or Amino-Phe), benzylphenylalanine (benzylphe), γ-carboxyglutamic acid (γ-carboxyglu), hydroxyproline (hydroxypro), p-carboxyl-phenylalanine (Cpa), α-aminoadipic acid (Aad), Nα-methyl valine (NMeVal), N-α-methyl leucine (NMeLeu), Nα-methylnorleucine (NMeNle), cyclopentylglycine (Cpg), cyclohexylglycine (Chg), acetylarginine (acetylarg), α, β-diaminopropionoic acid (Dpr), α, γ-diaminobutyric acid (Dab), diaminopropionic acid (Dap), cyclohexylalanine (Cha), 4-methyl-phenylalanine (MePhe), β, β-diphenyl-alanine (BiPhA), aminobutyric acid (Abu), 4-phenyl-phenylalanine (or biphenylalanine; 4Bip), α-amino-isobutyric acid (Aib), beta-alanine, beta-aminopropionic acid, piperidinic acid, aminocaprioic acid, aminoheptanoic acid, aminopimelic acid, desmosine, diaminopimelic acid, N-ethylglycine, N-ethylaspargine, hydroxylysine, allo-hydroxylysine, isodesmosine, allo-isoleucine, N-methylglycine, N-methylisoleucine, N-methylvaline, 4-hydroxyproline (Hyp), γ-carboxyglutamate, ε-N,N,N-trimethyllysine, ε-N-acetyllysine, O-phosphoserine, N-acetylserine, N-formylmethionine, 3-methylhistidine, 5-hydroxylysine, ω-methylarginine, 4-Amino-O-Phthalic Acid (4APA), and other similar amino acids, and derivatized forms of any of those specifically listed.

The term “isolated nucleic acid molecule” refers to a single or double-stranded polymer of deoxyribonucleotide or ribonucleotide bases read from the 5′ to the 3′ end (e.g., a GIPR nucleic acid sequence provided herein), or an analog thereof, that has been separated from at least about 50 percent of polypeptides, peptides, lipids, carbohydrates, polynucleotides or other materials with which the nucleic acid is naturally found when total nucleic acid is isolated from the source cells. Preferably, an isolated nucleic acid molecule is substantially free from any other contaminating nucleic acid molecules or other molecules that are found in the natural environment of the nucleic acid that would interfere with its use in polypeptide production or its therapeutic, diagnostic, prophylactic or research use.

The term “isolated polypeptide” refers to a polypeptide (e.g., a GIPR polypeptide sequence provided herein or an antigen binding protein of the present invention) that has been separated from at least about 50 percent of polypeptides, peptides, lipids, carbohydrates, polynucleotides, or other materials with which the polypeptide is naturally found when isolated from a source cell. Preferably, the isolated polypeptide is substantially free from any other contaminating polypeptides or other contaminants that are found in its natural environment that would interfere with its therapeutic, diagnostic, prophylactic or research use.

A composition of the present invention that includes a GLP-1 receptor agonist of the invention covalently linked, attached, or bound, either directly or indirectly through a linker moiety, to another an anti-GIPR antigen binding protein of the invention or is a “conjugate” or “conjugated” molecule, whether conjugated by chemical means (e.g., post-translationally or post-synthetically).

The term “encoding” refers to a polynucleotide sequence encoding one or more amino acids. The term does not require a start or stop codon.

The terms “identical” and percent “identity,” in the context of two or more nucleic acids or polypeptide sequences, refer to two or more sequences or subsequences that are the same. “Percent identity” means the percent of identical residues between the amino acids or nucleotides in the compared molecules and is calculated based on the size of the smallest of the molecules being compared. For these calculations, gaps in alignments (if any) can be addressed by a particular mathematical model or computer program (i.e., an “algorithm”). Methods that can be used to calculate the identity of the aligned nucleic acids or polypeptides include those described in Computational Molecular Biology, (Lesk, A. M., ed.), (1988) New York: Oxford University Press; Biocomputing Informatics and Genome Projects, (Smith, D. W., ed.), 1993, New York: Academic Press; Computer Analysis of Sequence Data, Part I, (Griffin, A. M., and Griffin, H. G., eds.), 1994, New Jersey: Humana Press; von Heinje, G., (1987) Sequence Analysis in Molecular Biology, New York: Academic Press; Sequence Analysis Primer, (Gribskov, M. and Devereux, J., eds.), 1991, New York: M. Stockton Press; and Carillo et al., (1988) SIAM J. Applied Math. 48:1073.

In calculating percent identity, the sequences being compared are aligned in a way that gives the largest match between the sequences. The computer program used to determine percent identity is the GCG program package, which includes GAP (Devereux et al., (1984) Nucl. Acid Res. 12:387; Genetics Computer Group, University of Wisconsin, Madison, Wis.). The computer algorithm GAP is used to align the two polypeptides or polynucleotides for which the percent sequence identity is to be determined. The sequences are aligned for optimal matching of their respective amino acid or nucleotide (the “matched span”, as determined by the algorithm). A gap opening penalty (which is calculated as 3× the average diagonal, wherein the “average diagonal” is the average of the diagonal of the comparison matrix being used; the “diagonal” is the score or number assigned to each perfect amino acid match by the particular comparison matrix) and a gap extension penalty (which is usually 1/10 times the gap opening penalty), as well as a comparison matrix such as PAM 250 or BLOSUM 62 are used in conjunction with the algorithm. In certain embodiments, a standard comparison matrix (see, Dayhoff et al., (1978) Atlas of Protein Sequence and Structure 5:345-352 for the PAM 250 comparison matrix; Henikoff et al., (1992) Proc. Natl. Acad. Sci. U.S.A. 89:10915-10919 for the BLOSUM 62 comparison matrix) is also used by the algorithm.

Recommended parameters for determining percent identity for polypeptides or nucleotide sequences using the GAP program are the following:

Algorithm: Needleman et al., 1970, J. Mol. Biol. 48:443-453;

Comparison matrix: BLOSUM 62 from Henikoff et al., 1992, supra;

Gap Penalty: 12 (but with no penalty for end gaps)

Gap Length Penalty: 4

Threshold of Similarity: 0

Certain alignment schemes for aligning two amino acid sequences can result in matching of only a short region of the two sequences, and this small aligned region can have very high sequence identity even though there is no significant relationship between the two full-length sequences. Accordingly, the selected alignment method (e.g., the GAP program) can be adjusted if so desired to result in an alignment that spans at least 50 contiguous amino acids of the target polypeptide.

The terms “GIPR polypeptide” and “GIPR protein” are used interchangeably and mean a naturally-occurring wild-type polypeptide expressed in a mammal, such as a human or a mouse, and includes naturally occurring alleles (e.g., naturally occurring allelic forms of human GIPR protein). For purposes of this disclosure, the term “GIPR polypeptide” can be used interchangeably to refer to any full-length GIPR polypeptide, e.g., SEQ ID NO: 3141, which consists of 466 amino acid residues and which is encoded by the nucleotide sequence SEQ ID NO: 3142, or SEQ ID NO: 3143, which consists of 430 amino acid residues and which is encoded by the nucleic acid sequence SEQ ID NO: 3144, or SEQ ID NO: 3145, which consists of 493 amino acid resides and which is encoded by the nucleic acid sequence of SEQ ID NO: 3146, or SEQ ID NO. 3147, which consists of 460 amino acids residues and which is encoded by the nucleic acid sequence of SEQ ID NO: 3148, or SEQ ID NO. 3149, which consists of 230 amino acids residues and which is encoded by the nucleic acid sequence of SEQ ID NO: 3150.

The term “GIPR polypeptide” also encompasses a GIPR polypeptide in which a naturally occurring GIPR polypeptide sequence (e.g., SEQ ID NOs: 3141, 3143 or 3145) has been modified. Such modifications include, but are not limited to, one or more amino acid substitutions, including substitutions with non-naturally occurring amino acids non-naturally-occurring amino acid analogs and amino acid mimetics.

In various embodiments, a GIPR polypeptide comprises an amino acid sequence that is at least about 90 percent identical to a naturally-occurring GIPR polypeptide (e.g., SEQ ID NOs: 3141, 3143 or 3145). In other embodiments, a GIPR polypeptide comprises an amino acid sequence that is at least about 95, 96, 97, 98, or 99 percent identical to a naturally-occurring GIPR polypeptide amino acid sequence (e.g., SEQ ID NOs: 3141, 3143 or 3145). Such GIPR polypeptides preferably, but need not, possess at least one activity of a wild-type GIPR polypeptide, such as the ability to bind GIP. The present invention also encompasses nucleic acid molecules encoding such GIPR polypeptide sequences.

The terms “GIPR activity assay” (also referred to as a “GIPR functional assay”) means an assay that can be used to measure GIP or a GIP binding protein activity in a cellular setting. In one embodiment, the “activity” (or “functional”) assay” can be a cAMP assay in GIPR expressing cells, in which GIP can induce cAMP signal, and the activity of a GIP/GIPR binding protein could be measured in the presence/absence of GIP ligand, in which IC50/EC50 and degree of inhibition/activation can be obtained (Biochemical and Biophysical Research Communications (2002) 290:1420-1426). In another embodiment, the “activity” (or “functional”) assay can be an insulin secretion assay in pancreatic beta cells, in which GIP can induce glucose-dependent insulin secretion, and the activity of a GIP/GIPR binding protein could be measured in the presence/absence of GIP ligand, in which IC50/EC50 and degree of inhibition/activation can be obtained (Biochemical and Biophysical Research Communications (2002) 290:1420-1426).

The term “GIPR binding assay” means an assay that can be used to measure binding of GIP to GIPR. In one embodiment, “GIPR binding assay” can be an assay using FMAT or FACS that measures fluorescence-labeled GIP binding to GIPR expression cells, and GIP/GIPR binding protein's activity can be measured for displacing fluorescence-labeled GIP binding to GIPR expression cells. In another embodiment, “GIPR binding assay” can be an assay that measures radioactive-labeled GIP binding to GIPR expression cells, and GIP/GIPR binding protein's activity can be measured for displacing radioactive labeled GIP binding to GIPR expression cells (Biochimica et Biophysica Acta (2001) 1547:143-155).

The terms “GIP”, “Gastric inhibitory polypeptide”, “glucose-dependent insulinotropic peptide” and “GIP ligand” are used interchangeably and mean a naturally-occurring wild-type polypeptide expressed in a mammal, such as a human or a mouse, and includes naturally occurring alleles (e.g., naturally occurring allelic forms of human GIP protein). For purposes of this disclosure, the term “GIP” can be used interchangeably to refer to any mature GIP polypeptide.

The 42 amino acid sequence of mature human GIP is:

(SEQ ID NO: 3151) YAEGTFISDY SIAMDKIHQQ DFVNWLLAQK GKKNDWKHNI TQ 

and is encoded by the DNA sequence:

(SEQ ID NO: 3152) tatgcggaag gcacctttat tagcgattat agcattgcga tggataaaat tcatcagcag gattttgtga actggctgct ggcgcagaaa ggcaaaaaaa acgattggaa acataacatt acccag.

The 42 amino acid sequence of mature murine GIP is:

(SEQ ID NO: 3153) YAEGTFISDY SIAMDKIRQQ DFVNWLLAQR GKKSDWKHNI TQ 

and is encoded by the DNA sequence:

(SEQ ID NO: 3154) tatgcggaag gcacctttat tagcgattat agcattgcga tggataaaat tcgccagcag gattttgtga actggctgct ggcgcagcgc ggcaaaaaaa gcgattggaa acataacatt acccag.

The 42 amino acid sequence of mature rat GIP is:

(SEQ ID NO: 3155) YAEGTFISDY SIAMDKIRQQ DFVNWLLAQK GKKNDWKHNL TQ 

and is encoded by the DNA sequence:

(SEQ ID NO: 3156) tatgcggaag gcacctttat tagcgattat agcattgcga tggataaaat tcgccagcag gattttgtga actggctgctg gcgcagaaag gcaaaaaaaa cgattggaaa cataacctga cccag.

A “GIPR antagonist” refers to compounds that reduce or inhibit GIP activation of GIPR. Such antagonists include chemically synthesized small molecules and antigen binding proteins.

An “antigen binding protein” as used herein means any protein that specifically binds a specified target antigen, such as a GIPR polypeptide (e.g., a human GIPR polypeptide such as provided in SEQ ID NOs: 3141, 3143 or 3145). The term encompasses intact antibodies that comprise at least two full-length heavy chains and two full-length light chains, as well as derivatives, variants, fragments, and mutations thereof. Examples of antibody fragments include Fab, Fab′, F(ab′)₂, and Fv fragments. An antigen binding protein also includes domain antibodies such as nanobodies and scFvs as described further below.

In general, a GIPR antigen binding protein is said to “specifically bind” its target antigen GIPR when the antigen binding protein exhibits essentially background binding to non-GIPR molecules. An antigen binding protein that specifically binds GIPR may, however, cross-react with GIPR polypeptides from different species. Typically, a GIPR antigen binding protein specifically binds human GIPR when the dissociation constant (KD) is ≤10⁻⁷ M as measured via a surface plasma resonance technique (e.g., BIACore, GE-Healthcare Uppsala, Sweden) or Kinetic Exclusion Assay (KinExA, Sapidyne, Boise, Id.). A GIPR antigen binding protein specifically binds human GIPR with “high affinity” when the KD is ≤5×10⁻⁹ M, and with “very high affinity” when the KD is ≤5×10⁻¹⁰ M, as measured using methods described.

“Antigen binding region” means a protein, or a portion of a protein, that specifically binds a specified antigen. For example, that portion of an antigen binding protein that contains the amino acid residues that interact with an antigen and confer on the antigen binding protein its specificity and affinity for the antigen is referred to as “antigen binding region.” An antigen binding region typically includes one or more “complementary binding regions” (“CDRs”) of an immunoglobulin, single-chain immunoglobulin, or camelid antibody. Certain antigen binding regions also include one or more “framework” regions. A “CDR” is an amino acid sequence that contributes to antigen binding specificity and affinity. “Framework” regions can aid in maintaining the proper conformation of the CDRs to promote binding between the antigen binding region and an antigen.

A “recombinant protein”, including a recombinant GIPR antigen binding protein, is a protein made using recombinant techniques, i.e., through the expression of a recombinant nucleic acid as described herein. Methods and techniques for the production of recombinant proteins are well known in the art.

The term “antibody” refers to an intact immunoglobulin of any isotype, or a fragment thereof that can compete with the intact antibody for specific binding to the target antigen, and includes, for instance, chimeric, humanized, fully human, and bispecific antibodies. An “antibody” as such is a species of an antigen binding protein. An intact antibody generally will comprise at least two full-length heavy chains and two full-length light chains. Antibodies may be derived solely from a single source, or may be “chimeric,” that is, different portions of the antibody may be derived from two different antibodies as described further below. The antigen binding proteins, antibodies, or binding fragments may be produced in hybridomas, by recombinant DNA techniques, or by enzymatic or chemical cleavage of intact antibodies.

The term “light chain” as used with respect to an antibody or fragments thereof includes a full-length light chain and fragments thereof having sufficient variable region sequence to confer binding specificity. A full-length light chain includes a variable region domain, VL, and a constant region domain, CL. The variable region domain of the light chain is at the amino-terminus of the polypeptide. Light chains include kappa chains and lambda chains.

The term “heavy chain” as used with respect to an antibody or fragment thereof includes a full-length heavy chain and fragments thereof having sufficient variable region sequence to confer binding specificity. A full-length heavy chain includes a variable region domain, VH, and three constant region domains, CH1, CH2, and CH3. The VH domain is at the amino-terminus of the polypeptide, and the CH domains are at the carboxyl-terminus, with the CH3 being closest to the carboxy-terminus of the polypeptide. Heavy chains may be of any isotype, including IgG (including IgG1, IgG2, IgG3 and IgG4 subtypes), IgA (including IgA1 and IgA2 subtypes), IgM and IgE.

The term “immunologically functional fragment” (or simply “fragment”) of an antibody or immunoglobulin chain (heavy or light chain), as used herein, is an antigen binding protein comprising a portion (regardless of how that portion is obtained or synthesized) of an antibody that lacks at least some of the amino acids present in a full-length chain but which is capable of specifically binding to an antigen. Such fragments are biologically active in that they bind specifically to the target antigen and can compete with other antigen binding proteins, including intact antibodies, for specific binding to a given epitope.

These biologically active fragments may be produced by recombinant DNA techniques, or may be produced by enzymatic or chemical cleavage of antigen binding proteins, including intact antibodies. Immunologically functional immunoglobulin fragments include, but are not limited to, Fab, Fab′, and F(ab′)₂ fragments.

In another embodiment, Fvs, domain antibodies and scFvs, and may be derived from an antibody of the present invention.

It is contemplated further that a functional portion of the antigen binding proteins disclosed herein, for example, one or more CDRs, could be covalently bound to a second protein or to a small molecule to create a therapeutic agent directed to a particular target in the body, possessing bifunctional therapeutic properties, or having a prolonged serum half-life.

A “Fab fragment” is comprised of one light chain and the CH1 and variable regions of one heavy chain. The heavy chain of a Fab molecule cannot form a disulfide bond with another heavy chain molecule.

An “Fc” region contains two heavy chain fragments comprising the CH₂ and CH3 domains of an antibody. The two heavy chain fragments are held together by two or more disulfide bonds and by hydrophobic interactions of the CH3 domains.

An “Fab′ fragment” contains one light chain and a portion of one heavy chain that contains the VH domain and the CH1 domain and also the region between the CH1 and CH₂ domains, such that an interchain disulfide bond can be formed between the two heavy chains of two Fab′ fragments to form an F(ab′)2 molecule.

An “F(ab′)2 fragment” contains two light chains and two heavy chains containing a portion of the constant region between the CH1 and CH₂ domains, such that an interchain disulfide bond is formed between the two heavy chains. A F(ab′)2 fragment thus is composed of two Fab′ fragments that are held together by a disulfide bond between the two heavy chains.

The “Fv region” comprises the variable regions from both the heavy and light chains, but lacks the constant regions.

“Single chain antibodies” or “scFvs” are Fv molecules in which the heavy and light chain variable regions have been connected by a flexible linker to form a single polypeptide chain, which forms an antigen-binding region. scFvs are discussed in detail in International Patent Application Publication No. WO 88/01649 and U.S. Pat. Nos. 4,946,778 and 5,260,203, the disclosures of which are incorporated by reference.

A “domain antibody” or “single chain immunoglobulin” is an immunologically functional immunoglobulin fragment containing only the variable region of a heavy chain or the variable region of a light chain. Examples of domain antibodies include Nanobodies®. In some instances, two or more VH regions are covalently joined with a peptide linker to create a bivalent domain antibody. The two VH regions of a bivalent domain antibody may target the same or different antigens.

A “bivalent antigen binding protein” or “bivalent antibody” comprises two antigen binding regions. In some instances, the two binding regions have the same antigen specificities. Bivalent antigen binding proteins and bivalent antibodies may be bispecific, see, infra.

A multispecific antigen binding protein” or “multispecific antibody” is one that targets more than one antigen or epitope.

A “bispecific,” “dual-specific” or “bifunctional” antigen binding protein or antibody is a hybrid antigen binding protein or antibody, respectively, having two different antigen binding sites. Bispecific antigen binding proteins and antibodies are a species of multispecific antigen binding protein or multispecific antibody and may be produced by a variety of methods including, but not limited to, fusion of hybridomas or linking of Fab′ fragments. See, e.g., Songsivilai and Lachmann, 1990, Clin. Exp. Immunol. 79:315-321; Kostelny et al., 1992, J. Immunol. 148:1547-1553. The two binding sites of a bispecific antigen binding protein or antibody will bind to two different epitopes, which may reside on the same or different protein targets.

The term “compete” when used in the context of antigen binding proteins (e.g., antibodies) means competition between antigen binding proteins is determined by an assay in which the antigen binding protein (e.g., antibody or immunologically functional fragment thereof) under test prevents or inhibits specific binding of a reference antigen binding protein to a common antigen (e.g., GIPR or a fragment thereof). Numerous types of competitive binding assays can be used, for example: solid phase direct or indirect radioimmunoassay (RIA), solid phase direct or indirect enzyme immunoassay (EIA), sandwich competition assay (see, e.g., Stahli et al., 1983, Methods in Enzymology 9:242-253); solid phase direct biotin-avidin EIA (see, e.g., Kirkland et al., 1986, J. Immunol. 137:3614-3619) solid phase direct labeled assay, solid phase direct labeled sandwich assay (see, e.g., Harlow and Lane, 1988, Antibodies, A Laboratory Manual, Cold Spring Harbor Press); solid phase direct label RIA using 1-125 label (see, e.g., Morel et al., 1988, Molec. Immunol. 25:7-15); solid phase direct biotin-avidin EIA (see, e.g., Cheung, et al., 1990, Virology 176:546-552); and direct labeled RIA (Moldenhauer et al., 1990, Scand. J. Immunol. 32:77-82). Typically, such an assay involves the use of purified antigen bound to a solid surface or cells bearing either of these, an unlabelled test antigen binding protein and a labeled reference antigen binding protein. Competitive inhibition is measured by determining the amount of label bound to the solid surface or cells in the presence of the test antigen binding protein. Usually the test antigen binding protein is present in excess. Additional details regarding methods for determining competitive binding are provided in the examples herein. Usually, when a competing antigen binding protein is present in excess, it will inhibit specific binding of a reference antigen binding protein to a common antigen by at least 40%, 45%, 50%, 55%, 60%, 65%, 70% or 75%. In some instances, binding is inhibited by at least 80%, 85%, 90%, 95%, or 97% or more.

The term “antigen” refers to a molecule or a portion of a molecule capable of being bound by a selective binding agent, such as an antigen binding protein (including, e.g., an antibody), and additionally capable of being used in an animal to produce antibodies capable of binding to that antigen. An antigen may possess one or more epitopes that are capable of interacting with different antigen binding proteins, e.g., antibodies.

The term “epitope” is the portion of a molecule that is bound by an antigen binding protein (for example, an antibody). The term includes any determinant capable of specifically binding to an antigen binding protein, such as an antibody. An epitope can be contiguous or non-contiguous (discontinuous) (e.g., in a polypeptide, amino acid residues that are not contiguous to one another in the polypeptide sequence but that within in context of the molecule are bound by the antigen binding protein). A conformational epitope is an epitope that exists within the conformation of an active protein but is not present in a denatured protein. In certain embodiments, epitopes may be mimetic in that they comprise a three dimensional structure that is similar to an epitope used to generate the antigen binding protein, yet comprise none or only some of the amino acid residues found in that epitope used to generate the antigen binding protein. Most often, epitopes reside on proteins, but in some instances may reside on other kinds of molecules, such as nucleic acids. Epitope determinants may include chemically active surface groupings of molecules such as amino acids, sugar side chains, phosphoryl or sulfonyl groups, and may have specific three dimensional structural characteristics, and/or specific charge characteristics. Generally, antigen binding proteins specific for a particular target antigen will preferentially recognize an epitope on the target antigen in a complex mixture of proteins and/or macromolecules.

As used herein, “substantially pure” means that the described species of molecule is the predominant species present, that is, on a molar basis it is more abundant than any other individual species in the same mixture. In certain embodiments, a substantially pure molecule is a composition wherein the object species comprises at least 50% (on a molar basis) of all macromolecular species present. In other embodiments, a substantially pure composition will comprise at least 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% of all macromolecular species present in the composition. In other embodiments, the object species is purified to essential homogeneity wherein contaminating species cannot be detected in the composition by conventional detection methods and thus the composition consists of a single detectable macromolecular species.

The term “treating” refers to any indicia of success in the treatment or amelioration of an injury, pathology or condition, including any objective or subjective parameter such as abatement; remission; diminishing of symptoms or making the injury, pathology or condition more tolerable to the patient; slowing in the rate of degeneration or decline; making the final point of degeneration less debilitating; improving a patient's physical or mental well-being. The treatment or amelioration of symptoms can be based on objective or subjective parameters; including the results of a physical examination, neuropsychiatric exams, and/or a psychiatric evaluation. For example, certain methods presented herein successfully treat cardiovascular disease such as atherosclerosis by decreasing the incidence of cardiovascular disease, causing remission of cardiovascular disease and/or ameliorating a symptom associated with cardiovascular disease.

An “effective amount” is generally an amount sufficient to reduce the severity and/or frequency of symptoms, eliminate the symptoms and/or underlying cause, prevent the occurrence of symptoms and/or their underlying cause, and/or improve or remediate the damage that results from or is associated with the disease state (e.g., diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels or diabetic nephropathy. In some embodiments, the effective amount is a therapeutically effective amount or a prophylactically effective amount. A “therapeutically effective amount” is an amount sufficient to remedy a disease state (e.g. atherosclerosis) or symptoms, particularly a state or symptoms associated with the disease state, or otherwise prevent, hinder, retard or reverse the progression of the disease state or any other undesirable symptom associated with the disease in any way whatsoever. A “prophylactically effective amount” is an amount of a pharmaceutical composition that, when administered to a subject, will have the intended prophylactic effect, e.g., preventing or delaying the onset (or reoccurrence) of the disease state, or reducing the likelihood of the onset (or reoccurrence) of the disease state or associated symptoms. The full therapeutic or prophylactic effect does not necessarily occur by administration of one dose, and may occur only after administration of a series of doses. Thus, a therapeutically or prophylactically effective amount may be administered in one or more administrations.

The terms “therapeutically effective dose” and “therapeutically effective amount,” as used herein, means an amount of a GIPR binding protein that elicits a biological or medicinal response in a tissue system, animal, or human being sought by a researcher, physician, or other clinician, which includes alleviation or amelioration of the symptoms of the disease or disorder being treated, i.e., an amount of a GIPR binding protein that supports an observable level of one or more desired biological or medicinal response, for example lowering blood glucose, insulin, triglyceride, or cholesterol levels; reducing body weight; or improving glucose tolerance, energy expenditure, or insulin sensitivity.

The term “polynucleotide” or “nucleic acid” includes both single-stranded and double-stranded nucleotide polymers. The nucleotides comprising the polynucleotide can be ribonucleotides or deoxyribonucleotides or a modified form of either type of nucleotide. The modifications include base modifications such as bromouridine and inosine derivatives, ribose modifications such as 2′,3′-dideoxyribose, and internucleotide linkage modifications such as phosphorothioate, phosphorodithioate, phosphoroselenoate, phosphorodiselenoate, phosphoroanilothioate, phoshoraniladate and phosphoroamidate.

The term “oligonucleotide” means a polynucleotide comprising 200 or fewer nucleotides. In some embodiments, oligonucleotides are 10 to 60 bases in length. In other embodiments, oligonucleotides are 12, 13, 14, 15, 16, 17, 18, 19, or 20 to 40 nucleotides in length. Oligonucleotides may be single stranded or double stranded, e.g., for use in the construction of a mutant gene. Oligonucleotides may be sense or antisense oligonucleotides. An oligonucleotide can include a label, including a radiolabel, a fluorescent label, a hapten or an antigenic label, for detection assays. Oligonucleotides may be used, for example, as PCR primers, cloning primers or hybridization probes.

An “isolated nucleic acid molecule” means a DNA or RNA of genomic, mRNA, cDNA, or synthetic origin or some combination thereof which is not associated with all or a portion of a polynucleotide in which the isolated polynucleotide is found in nature, or is linked to a polynucleotide to which it is not linked in nature. For purposes of this disclosure, it should be understood that “a nucleic acid molecule comprising” a particular nucleotide sequence does not encompass intact chromosomes. Isolated nucleic acid molecules “comprising” specified nucleic acid sequences may include, in addition to the specified sequences, coding sequences for up to ten or even up to twenty other proteins or portions thereof, or may include operably linked regulatory sequences that control expression of the coding region of the recited nucleic acid sequences, and/or may include vector sequences.

Unless specified otherwise, the left-hand end of any single-stranded polynucleotide sequence discussed herein is the 5′ end; the left-hand direction of double-stranded polynucleotide sequences is referred to as the 5′ direction. The direction of 5′ to 3′ addition of nascent RNA transcripts is referred to as the transcription direction; sequence regions on the DNA strand having the same sequence as the RNA transcript that are 5′ to the 5′ end of the RNA transcript are referred to as “upstream sequences;” sequence regions on the DNA strand having the same sequence as the RNA transcript that are 3′ to the 3′ end of the RNA transcript are referred to as “downstream sequences.”

The term “control sequence” refers to a polynucleotide sequence that can affect the expression and processing of coding sequences to which it is ligated. The nature of such control sequences may depend upon the host organism. In particular embodiments, control sequences for prokaryotes may include a promoter, a ribosomal binding site, and a transcription termination sequence. For example, control sequences for eukaryotes may include promoters comprising one or a plurality of recognition sites for transcription factors, transcription enhancer sequences, and transcription termination sequences. “Control sequences” can include leader sequences and/or fusion partner sequences.

The term “vector” means any molecule or entity (e.g., nucleic acid, plasmid, bacteriophage or virus) used to transfer protein coding information into a host cell.

The term “expression vector” or “expression construct” refers to a vector that is suitable for transformation of a host cell and contains nucleic acid sequences that direct and/or control (in conjunction with the host cell) expression of one or more heterologous coding regions operatively linked thereto. An expression construct may include, but is not limited to, sequences that affect or control transcription, translation, and, if introns are present, affect RNA splicing of a coding region operably linked thereto.

As used herein, “operably linked” means that the components to which the term is applied are in a relationship that allows them to carry out their inherent functions under suitable conditions. For example, a control sequence in a vector that is “operably linked” to a protein coding sequence is ligated thereto so that expression of the protein coding sequence is achieved under conditions compatible with the transcriptional activity of the control sequences.

The term “host cell” means a cell that has been transformed with a nucleic acid sequence and thereby expresses a gene of interest. The term includes the progeny of the parent cell, whether or not the progeny is identical in morphology or in genetic make-up to the original parent cell, so long as the gene of interest is present.

The terms “polypeptide” or “protein” are used interchangeably herein to refer to a polymer of amino acid residues. The terms also apply to amino acid polymers in which one or more amino acid residues is an analog or mimetic of a corresponding naturally occurring amino acid, as well as to naturally occurring amino acid polymers. The terms can also encompass amino acid polymers that have been modified, e.g., by the addition of carbohydrate residues to form glycoproteins, or phosphorylated. Polypeptides and proteins can be produced by a naturally-occurring and non-recombinant cell; or it is produced by a genetically-engineered or recombinant cell, and comprise molecules having the amino acid sequence of the native protein, or molecules having deletions from, additions to, and/or substitutions of one or more amino acids of the native sequence. The terms “polypeptide” and “protein” specifically encompass GIPR antigen binding proteins, antibodies, or sequences that have deletions from, additions to, and/or substitutions of one or more amino acids of an antigen-binding protein. The term “polypeptide fragment” refers to a polypeptide that has an amino-terminal deletion, a carboxyl-terminal deletion, and/or an internal deletion as compared with the full-length protein. Such fragments may also contain modified amino acids as compared with the full-length protein. In certain embodiments, fragments are about five to 500 amino acids long. For example, fragments may be at least 5, 6, 8, 10, 14, 20, 50, 70, 100, 110, 150, 200, 250, 300, 350, 400, or 450 amino acids long. Useful polypeptide fragments include immunologically functional fragments of antibodies, including binding domains.

The term “isolated protein” means that a subject protein (1) is free of at least some other proteins with which it would normally be found, (2) is essentially free of other proteins from the same source, e.g., from the same species, (3) is expressed by a cell from a different species, (4) has been separated from at least about 50 percent of polynucleotides, lipids, carbohydrates, or other materials with which it is associated in nature, (5) is operably associated (by covalent or noncovalent interaction) with a polypeptide with which it is not associated in nature, or (6) does not occur in nature. Typically, an “isolated protein” constitutes at least about 5%, at least about 10%, at least about 25%, or at least about 50% of a given sample. Genomic DNA, cDNA, mRNA or other RNA, of synthetic origin, or any combination thereof may encode such an isolated protein. Preferably, the isolated protein is substantially free from proteins or polypeptides or other contaminants that are found in its natural environment that would interfere with its therapeutic, diagnostic, prophylactic, research or other use.

A “variant” of a polypeptide (e.g., an antigen binding protein such as an antibody) comprises an amino acid sequence wherein one or more amino acid residues are inserted into, deleted from and/or substituted into the amino acid sequence relative to another polypeptide sequence. Variants include fusion proteins.

A “derivative” of a polypeptide is a polypeptide (e.g., an antigen binding protein such as an antibody) that has been chemically modified in some manner distinct from insertion, deletion, or substitution variants, e.g., via conjugation to another chemical moiety.

The term “naturally occurring” as used throughout the specification in connection with biological materials such as polypeptides, nucleic acids, host cells, and the like, refers to materials which are found in nature.

A “subject” or “patient” as used herein can be any mammal. In a typical embodiment, the subject or patient is a human.

As disclosed herein, a GIPR polypeptide described by the instant disclosure can be engineered and/or produced using standard molecular biology methodology. In various examples, a nucleic acid sequence encoding a GIPR, which can comprise all or a portion of SEQ ID NOs:1, 3 or 5, can be isolated and/or amplified from genomic DNA, or cDNA using appropriate oligonucleotide primers. Primers can be designed based on the nucleic and amino acid sequences provided herein according to standard (RT)-PCR amplification techniques. The amplified GIPR nucleic acid can then be cloned into a suitable vector and characterized by DNA sequence analysis.

Oligonucleotides for use as probes in isolating or amplifying all or a portion of the GIPR sequences provided herein can be designed and generated using standard synthetic techniques, e.g., automated DNA synthesis apparatus, or can be isolated from a longer sequence of DNA.

The 466 amino acid sequence of human GIPR is (Volz et al., FEBS Lett. 373:23-29 (1995); NCBI Reference Sequence: NP_0001555):

(SEQ ID NO: 3141) MTTSPILQLL LRLSLCGLLL QRAETGSKGQ TAGELYQRWE RYRRECQETL AAAEPPSGLA CNGSFDMYVC WDYAAPNATA RASCPWYLPW HHHVAAGFVL RQCGSDGQWG LWRDHTQCEN PEKNEAFLDQ RLILERLQVM YTVGYSLSLA TLLLALLILS LFRRLHCTRN YIHINLFTSF MLRAAAILSR DRLLPRPGPY LGDQALALWN QALAACRTAQ IVTQYCVGAN YTWLLVEGVY LHSLLVLVGG SEEGHFRYYL LLGWGAPALF VIPWVIVRYL YENTQCWERN EVKAIWWIIR TPILMTILIN FLIFIRILGI LLSKLRTRQM RCRDYRLRLA RSTLTLVPLL GVHEVVFAPV TEEQARGALR FAKLGFEIFL SSFQGFLVSV LYCFINKEVQ SEIRRGWHHC RLRRSLGEEQ RQLPERAFRA LPSGSGPGEV PTSRGLSSGT LPGPGNEASR ELESYC 

and is encoded by the DNA sequence (NCBI Reference Sequence: NM_000164):

(SEQ ID NO: 3142) ggcagcggtg gcaggggctg caggagcaag tgaccaggag caggactggg gacaggcctg atcgcccctg cacgaaccag acccttcgcc gccctcacga tgactacctc tccgatcctg cagctgctgc tgcggctctc actgtgcggg ctgctgctcc agagggcgga gacaggctct aaggggcaga cggcggggga gctgtaccag cgctgggaac ggtaccgcag ggagtgccag gagaccttgg cagccgcgga accgccttca ggcctcgcct gtaacgggtc cttcgatatg tacgtctgct gggactatgc tgcacccaat gccactgccc gtgcgtcctg cccctggtac ctgccctggc accaccatgt ggctgcaggt ttcgtcctcc gccagtgtgg cagtgatggc caatggggac tttggagaga ccatacacaa tgtgagaacc cagagaagaa tgaggccttt ctggaccaaa ggctcatctt ggagcggttg caggtcatgt acactgtcgg ctactccctg tctctcgcca cactgctgct agccctgctc atcttgagtt tgttcaggcg gctacattgc actagaaact atatccacat caacctgttc acgtctttca tgctgcgagc tgcggccatt ctcagccgag accgtctgct acctcgacct ggcccctacc ttggggacca ggcccttgcg ctgtggaacc aggccctcgc tgcctgccgc acggcccaga tcgtgaccca gtactgcgtg ggtgccaact acacgtggct gctggtggag ggcgtctacc tgcacagtct cctggtgctc gtgggaggct ccgaggaggg ccacttccgc tactacctgc tcctcggctg gggggccccc gcgcttttcg tcattccctg ggtgatcgtc aggtacctgt acgagaacac gcagtgctgg gagcgcaacg aagtcaaggc catttggtgg attatacgga cccccatcct catgaccatc ttgattaatt tcctcatttt tatccgcatt cttggcattc tcctgtccaa gctgaggaca cggcaaatgc gctgccggga ttaccggctg aggctggctc gctccacgct gacgctggtg cccctgctgg gtgtccacga ggtggtgttt gctcccgtga cagaggaaca ggcccggggc gccctgcgct tcgccaagct cggctttgag atcttcctca gctccttcca gggcttcctg gtcagcgtcc tctactgctt catcaacaag gaggtgcagt cggagatccg ccgtggctgg caccactgcc gcctgcgccg cagcctgggc gaggagcaac gccagctccc ggagcgcgcc ttccgggccc tgccctccgg ctccggcccg ggcgaggtcc ccaccagccg cggcttgtcc tcggggaccc tcccagggcc tgggaatgag gccagccggg agttggaaag ttactgctag ggggcgggat ccccgtgtct gttcagttag catggattta ttgagtgcca actgcgtgcc aggcccagta cggaggacgc tggggaaatg gtgaaggaaa cagaaaaaag gtccctgccc ttctggagat gacaactgag tggggaaaac agaccgtgaa cacaaaacat caagttccac acacgctatg gaatggttat gaagggaagc gagaaggggg cctagggtgg tctgggaggc gtctccaagg aggtgacact taagccatcc ccgaaagagg tgaaagagat cactttgggg agagctggag aacaggattc taggcggaag cgatagcata ggcaaaggcc cttgggcagg aaggcgctca gccttggctg gagtagaatt aagtcagagc caacaggtgg ggagagacag agaagtgggc aggggcaccc aagttgggat ttcatttcag gtgcattgga gattcttagg agtgtctctt gggggtaata ttttattttt taaaaaatga ggat.

A 430 amino acid isoform of human GIPR (isoform X1), predicted by automated computational analysis, has the sequence (NCBI Reference Sequence XP_005258790):

(SEQ ID NO: 3143) MTTSPILQLL LRLSLCGLLL QRAETGSKGQ TAGELYQRWE RYRRECQETL AAAEPPSVAA GFVLRQCGSD GQWGLWRDHT QCENPEKNEA FLDQRLILER LQVMYTVGYS LSLATLLLAL LILSLFRRLH CTRNYIHINL FTSFMLRAAA ILSRDRLLPR PGPYLGDQAL ALWNQALAAC RTAQIVTQYC VGANYTWLLV EGVYLHSLLV LVGGSEEGHF RYYLLLGWGA PALFVIPWVI VRYLYENTQC WERNEVKAIW WIIRTPILMT ILINFLIFIR ILGILLSKLR TRQMRCRDYR LRLARSTLTL VPLLGVHEVV FAPVTEEQAR GALRFAKLGF EIFLSSFQGF LVSVLYCFIN KEVQSEIRRG WHHCRLRRSL GEEQRQLPER AFRALPSGSG PGEVPTSRGL SSGTLPGPGN EASRELESYC

and is encoded by the DNA sequence:

(SEQ ID NO: 3144) atgaccacca gcccgattct gcagctgctg ctgcgcctga gcctgtgcgg cctgctgctg cagcgcgcgg aaaccggcag caaaggccag accgcgggcg aactgtatca gcgctgggaa cgctatcgcc gcgaatgcca ggaaaccctg gcggcggcgg aaccgccgag cgtggcggcg ggctttgtgc tgcgccagtg cggcagcgat ggccagtggg gcctgtggcg cgatcatacc cagtgcgaaa acccggaaaa aaacgaagcg tttctggatc agcgcctgat tctggaacgc ctgcaggtga tgtataccgt gggctatagc ctgagcctgg cgaccctgct gctggcgctg ctgattctga gcctgtttcg ccgcctgcat tgcacccgca actatattca tattaacctg tttaccagct ttatgctgcg cgcggcggcg attctgagcc gcgatcgcct gctgccgcgc ccgggcccgt atctgggcga tcaggcgctg gcgctgtgga accaggcgct ggcggcgtgc cgcaccgcgc agattgtgac ccagtattgc gtgggcgcga actatacctg gctgctggtg gaaggcgtgt atctgcatag cctgctggtg ctggtgggcg gcagcgaaga aggccatttt cgctattatc tgctgctggg ctggggcgcg ccggcgctgt ttgtgattcc gtgggtgatt gtgcgctatc tgtatgaaaa cacccagtgc tgggaacgca acgaagtgaa agcgatttgg tggattattc gcaccccgat tctgatgacc attctgatta actttctgat ttttattcgc attctgggca ttctgctgag caaactgcgc acccgccaga tgcgctgccg cgattatcgc ctgcgcctgg cgcgcagcac cctgaccctg gtgccgctgc tgggcgtgca tgaagtggtg tttgcgccgg tgaccgaaga acaggcgcgc ggcgcgctgc gctttgcgaa actgggcttt gaaatttttc tgagcagctt tcagggcttt ctggtgagcg tgctgtattg ctttattaac aaagaagtgc agagcgaaat tcgccgcggc tggcatcatt gccgcctgcg ccgcagcctg ggcgaagaac agcgccagct gccggaacgc gcgtttcgcg cgctgccgag cggcagcggc ccgggcgaag tgccgaccag ccgcggcctg agcagcggca ccctgccggg cccgggcaac gaagcgagcc gcgaactgga aagctattgc.

A 493 amino acid isoform of human GIPR, produced by alternative splicing, has the sequence (Gremlich et al., Diabetes 44:1202-8 (1995); UniProtKB Sequence Identifier: P48546-2):

(SEQ ID NO: 3145) MTTSPILQLL LRLSLCGLLL QRAETGSKGQ TAGELYQRWE RYRRECQETL AAAEPPSGLA CNGSFDMYVC WDYAAPNATA RASCPWYLPW HHHVAAGFVL RQCGSDGQWG LWRDHTQCEN PEKNEAFLDQ RLILERLQVM YTVGYSLSLA TLLLALLILS LFRRLHCTRN YIHINLFTSF MLRAAAILSR DRLLPRPGPY LGDQALALWN QALAACRTAQ IVTQYCVGAN YTWLLVEGVY LHSLLVLVGG SEEGHFRYYL LLGWGAPALF VIPWVIVRYL YENTQCWERN EVKAIWWIIR TPILMTILIN FLIFIRILGI LLSKLRTRQM RCRDYRLRLA RSTLTLVPLL GVHEVVFAPV TEEQARGALR FAKLGFEIFL SSFQGFLVSV LYCFINKEVG RDPAAAPALW RRRGTAPPLS AIVSQVQSEI RRGWHHCRLR RSLGEEQRQL PERAFRALPS GSGPGEVPTS RGLSSGTLPG PGNEASRELE SYC

and is encoded by the DNA sequence:

(SEQ ID NO: 3146) atgaccacca gcccgattct gcagctgctg ctgcgcctga gcctgtgcgg cctgctgctg cagcgcgcgg aaaccggcag caaaggccag accgcgggcg aactgtatca gcgctgggaa cgctatcgcc gcgaatgcca ggaaaccctg gcggcggcgg aaccgccgag cggcctggcg tgcaacggca gctttgatat gtatgtgtgc tgggattatg cggcgccgaa cgcgaccgcg cgcgcgagct gcccgtggta tctgccgtgg catcatcatg tggcggcggg ctttgtgctg cgccagtgcg gcagcgatgg ccagtggggc ctgtggcgcg atcataccca gtgcgaaaac ccggaaaaaa acgaagcgtt tctggatcag cgcctgattc tggaacgcct gcaggtgatg tataccgtgg gctatagcct gagcctggcg accctgctgc tggcgctgct gattctgagc ctgtttcgcc gcctgcattg cacccgcaac tatattcata ttaacctgtt taccagcttt atgctgcgcg cggcggcgat tctgagccgc gatcgcctgc tgccgcgccc gggcccgtat ctgggcgatc aggcgctggc gctgtggaac caggcgctgg cggcgtgccg caccgcgcag attgtgaccc agtattgcgt gggcgcgaac tatacctggc tgctggtgga aggcgtgtat ctgcatagcc tgctggtgct ggtgggcggc agcgaagaag gccattttcg ctattatctg ctgctgggct ggggcgcgcc ggcgctgttt gtgattccgt gggtgattgt gcgctatctg tatgaaaaca cccagtgctg ggaacgcaac gaagtgaaag cgatttggtg gattattcgc accccgattc tgatgaccat tctgattaac tttctgattt ttattcgcat tctgggcatt ctgctgagca aactgcgcac ccgccagatg cgctgccgcg attatcgcct gcgcctggcg cgcagcaccc tgaccctggt gccgctgctg ggcgtgcatg aagtggtgtt tgcgccggtg accgaagaac aggcgcgcgg cgcgctgcgc tttgcgaaac tgggctttga aatttttctg agcagctttc agggctttct ggtgagcgtg ctgtattgct ttattaacaa agaagtgggc cgcgatccgg cggcggcgcc ggcgctgtgg cgccgccgcg gcaccgcgcc gccgctgagc gcgattgtga gccaggtgca gagcgaaatt cgccgcggct ggcatcattg ccgcctgcgc cgcagcctgg gcgaagaaca gcgccagctg ccggaacgcg cgtttcgcgc gctgccgagc ggcagcggcc cgggcgaagt gccgaccagc cgcggcctga gcagcggcac cctgccgggc ccgggcaacg aagcgagccg cgaactggaa agctattgct aa

The 460 amino acid sequence of murine GIPR is (NCBI Reference Sequence: NP_001074284; uniprotKB/Swiss-Prot Q0P543-1); see Vassilatis et al., PNAS USA 2003, 100:4903-4908.

(SEQ ID NO: 3147) MPLRLLLLLL WLWGLQWAET DSEGQTTTGE LYQRWEHYGQ ECQKMLETTE PPSGLACNGS FDMYACWNYT AANTTARVSC PWYLPWFRQV SAGFVFRQCG SDGQWGSWRD HTQCENPEKN GAFQDQTLIL ERLQIMYTVG YSLSLTTLLL ALLILSLFRR LHCTRNYIHM NLFTSFMLRA AAILTRDQLL PPLGPYTGDQ APTPWNQALA ACRTAQIMTQ YCVGANYTWL LVEGVYLHHL LVIVGRSEKG HFRCYLLLGW GAPALFVIPW VIVRYLRENT QCWERNEVKA IWWIIRTPIL ITILINFLIF IRILGILVSK LRTRQMRCPD YRLRLARSTL TLVPLLGVHE VVFAPVTEEQ VEGSLRFAKL AFEIFLSSFQ GFLVSVLYCFINKEVQSEIRQ GWRHRRLRLS LQEQRPRPHQ ELAPRAVPLS SACREAAVGN ALPSGMLHVP GDEVLESYC

and is encoded by the DNA sequence (NCBI Reference Sequence: NM_001080815):

(SEQ ID NO: 3148) atgccgctgc gcctgctgct gctgctgctg tggctgtggg gcctgcagtg ggcggaaacc gatagcgaag gccagaccac caccggcgaa ctgtatcagc gctgggaaca ttatggccag gaatgccaga aaatgctgga aaccaccgaa ccgccgagcg gcctggcgtg caacggcagc tttgatatgt atgcgtgctg gaactatacc gcggcgaaca ccaccgcgcg cgtgagctgc ccgtggtatc tgccgtggtt tcgccaggtg agcgcgggct ttgtgtttcg ccagtgcggc agcgatggcc agtggggcag ctggcgcgat catacccagt gcgaaaaccc ggaaaaaaac ggcgcgtttc aggatcagac cctgattctg gaacgcctgc agattatgta taccgtgggc tatagcctga gcctgaccac cctgctgctg gcgctgctga ttctgagcct gtttcgccgc ctgcattgca cccgcaacta tattcatatg aacctgttta ccagctttat gctgcgcgcg gcggcgattc tgacccgcga tcagctgctg ccgccgctgg gcccgtatac cggcgatcag gcgccgaccc cgtggaacca ggcgctggcg gcgtgccgca ccgcgcagat tatgacccag tattgcgtgg gcgcgaacta tacctggctg ctggtggaag gcgtgtatct gcatcatctg ctggtgattg tgggccgcag cgaaaaaggc cattttcgct gctatctgct gctgggctgg ggcgcgccgg cgctgtttgt gattccgtgg gtgattgtgc gctatctgcg cgaaaacacc cagtgctggg aacgcaacga agtgaaagcg atttggtgga ttattcgcac cccgattctg attaccattc tgattaactt tctgattttt attcgcattc tgggcattct ggtgagcaaa ctgcgcaccc gccagatgcg ctgcccggat tatcgcctgc gcctggcgcg cagcaccctg accctggtgc cgctgctggg cgtgcatgaa gtggtgtttg cgccggtgac cgaagaacag gtggaaggca gcctgcgctt tgcgaaactg gcgtttgaaa tttttctgag cagctttcag ggctttctgg tgagcgtgct gtattgcttt attaacaaag aagtgcagag cgaaattcgc cagggctggc gccatcgccg cctgcgcctg agcctgcagg aacagcgccc gcgcccgcat caggaactgg cgccgcgcgc ggtgccgctg agcagcgcgt gccgcgaagc ggcggtgggc aacgcgctgc cgagcggcat gctgcatgtg ccgggcgatg aagtgctgga aagctattgc taa

A 230 amino acid isoform of murine GIPR, produced by alternative splicing, has the sequence (Gerhard et al., Genome Res, 14:2121-2127 (2004); NCBI Reference Sequence: AAI20674).

(SEQ ID NO: 3149) MPLRLLLLLL WLWGLQWAET DSEGQTTTGE LYQRWEHYGQ ECQKMLETTE PPSGLACNGS FDMYACWNYT AANTTARVSC PWYLPWFRQV SAGFVFRQCG SDGQWGSWRD HTQCENPEKN GAFQDQTLIL ERLQIMYTVG YSLSLTTLLL ALLILSLFRR LHCTRNYIHM NLFTSFMLRA AAILTRDQLL PPLGPYTGDQ APTPWNQVLH RLLPGGTKTF PIYFRTFPHH

and is encoded by the DNA sequence:

(SEQ ID NO: 3150) atgccgctgc gcctgctgct gctgctgctg tggctgtggg gcctgcagtg ggcggaaacc gatagcgaag gccagaccac caccggcgaa ctgtatcagc gctgggaaca ttatggccag gaatgccaga aaatgctgga aaccaccgaa ccgccgagcg gcctggcgtg caacggcagc tttgatatgt atgcgtgctg gaactatacc gcggcgaaca ccaccgcgcg cgtgagctgc ccgtggtatc tgccgtggtt tcgccaggtg agcgcgggct ttgtgtttcg ccagtgcggc agcgatggcc agtggggcag ctggcgcgat catacccagt gcgaaaaccc ggaaaaaaac ggcgcgtttc aggatcagac cctgattctg gaacgcctgc agattatgta taccgtgggc tatagcctga gcctgaccac cctgctgctg gcgctgctga ttctgagcct gtttcgccgc ctgcattgca cccgcaacta tattcatatg aacctgttta ccagctttat gctgcgcgcg gcggcgattc tgacccgcga tcagctgctg ccgccgctgg gcccgtatac cggcgatcag gcgccgaccc cgtggaacca ggtgctgcat cgcctgctgc cgggcggcac caaaaccttt ccgatttatt ttcgcacctt tccgcatcat taa.

As stated herein, the term “GIPR polypeptide” encompasses naturally occurring GIPR polypeptide sequences, e.g., human amino acid sequences SEQ ID NOs: 3141, 3143 or 3145. The term “GIPR polypeptide,” however, also encompasses polypeptides comprising an amino acid sequence that differs from the amino acid sequence of a naturally occurring GIPR polypeptide sequence, e.g., SEQ ID NOs: 3141, 3143 or 3145, by one or more amino acids, such that the sequence is at least 90% identical to SEQ ID NOs: 3141, 3143 or 3145. GIPR polypeptides can be generated by introducing one or more amino acid substitutions, either conservative or non-conservative and using naturally or non-naturally occurring amino acids, at particular positions of the GIPR polypeptide.

A “conservative amino acid substitution” can involve a substitution of a native amino acid residue (i.e., a residue found in a given position of the wild-type GIPR polypeptide sequence) with a nonnative residue (i.e., a residue that is not found in a given position of the wild-type GIPR polypeptide sequence) such that there is little or no effect on the polarity or charge of the amino acid residue at that position. Conservative amino acid substitutions also encompass non-naturally occurring amino acid residues that are typically incorporated by chemical peptide synthesis rather than by synthesis in biological systems. These include peptidomimetics, and other reversed or inverted forms of amino acid moieties.

Naturally occurring residues can be divided into classes based on common side chain properties:

(1) hydrophobic: norleucine, Met, Ala, Val, Leu, Ile;

(2) neutral hydrophilic: Cys, Ser, Thr;

(3) acidic: Asp, Glu;

(4) basic: Asn, Gln, His, Lys, Arg;

(5) residues that influence chain orientation: Gly, Pro; and

(6) aromatic: Trp, Tyr, Phe.

Additional groups of amino acids can also be formulated using the principles described in, e.g., Creighton (1984) PROTEINS: STRUCTURE AND MOLECULAR PROPERTIES (2d Ed. 1993), W.H. Freeman and Company. In some instances it can be useful to further characterize substitutions based on two or more of such features (e.g., substitution with a “small polar” residue, such as a Thr residue, can represent a highly conservative substitution in an appropriate context).

Conservative substitutions can involve the exchange of a member of one of these classes for another member of the same class. Non-conservative substitutions can involve the exchange of a member of one of these classes for a member from another class.

Synthetic, rare, or modified amino acid residues having known similar physiochemical properties to those of an above-described grouping can be used as a “conservative” substitute for a particular amino acid residue in a sequence. For example, a D-Arg residue may serve as a substitute for a typical L-Arg residue. It also can be the case that a particular substitution can be described in terms of two or more of the above described classes (e.g., a substitution with a small and hydrophobic residue means substituting one amino acid with a residue(s) that is found in both of the above-described classes or other synthetic, rare, or modified residues that are known in the art to have similar physiochemical properties to such residues meeting both definitions).

Nucleic acid sequences encoding a GIPR polypeptide provided herein, including those degenerate to SEQ ID NOs: 3141, 3143 or 3145, and those encoding polypeptide variants of SEQ ID NOs: 3141, 3143 or 3145 form other aspects of the instant disclosure.

In order to express the GIPR nucleic acid sequences provided herein, the appropriate coding sequences, e.g., SEQ ID NOs: 3141, 3143 or 3145, can be cloned into a suitable vector and after introduction in a suitable host, the sequence can be expressed to produce the encoded polypeptide according to standard cloning and expression techniques, which are known in the art (e.g., as described in Sambrook, J., Fritsh, E. F., and Maniatis, T. Molecular Cloning: A Laboratory Manual 2nd, ed., Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1989). The invention also relates to such vectors comprising a nucleic acid sequence according to the invention.

A “vector” refers to a delivery vehicle that (a) promotes the expression of a polypeptide-encoding nucleic acid sequence; (b) promotes the production of the polypeptide therefrom; (c) promotes the transfection/transformation of target cells therewith; (d) promotes the replication of the nucleic acid sequence; (e) promotes stability of the nucleic acid; (f) promotes detection of the nucleic acid and/or transformed/transfected cells; and/or (g) otherwise imparts advantageous biological and/or physiochemical function to the polypeptide-encoding nucleic acid. A vector can be any suitable vector, including chromosomal, non-chromosomal, and synthetic nucleic acid vectors (a nucleic acid sequence comprising a suitable set of expression control elements). Examples of such vectors include derivatives of SV40, bacterial plasmids, phage DNA, baculovirus, yeast plasmids, vectors derived from combinations of plasmids and phage DNA, and viral nucleic acid (RNA or DNA) vectors.

A recombinant expression vector can be designed for expression of a GIPR protein in prokaryotic (e.g., E. coli) or eukaryotic cells (e.g., insect cells, using baculovirus expression vectors, yeast cells, or mammalian cells). In one embodiment the host cell is a mammalian, non-human host cell. Representative host cells include those hosts typically used for cloning and expression, including Escherichia coli strains TOP10F′, TOP10, DH10B, DH5a, HB101, W3110, BL21(DE3) and BL21 (DE3)pLysS, BLUESCRIPT (Stratagene), mammalian cell lines CHO, CHO-K1, HEK293, 293-EBNA pIN vectors (Van Heeke & Schuster, J. Biol. Chem. 264: 5503-5509 (1989); pET vectors (Novagen, Madison Wis.). Alternatively, the recombinant expression vector can be transcribed and translated in vitro, for example using T7 promoter regulatory sequences and T7 polymerase and an in vitro translation system. Preferably, the vector contains a promoter upstream of the cloning site containing the nucleic acid sequence encoding the polypeptide. Examples of promoters, which can be switched on and off, include the lac promoter, the T7 promoter, the trc promoter, the tac promoter and the trp promoter.

Thus, provided herein are vectors comprising a nucleic acid sequence encoding GIPR that facilitate the expression of recombinant GIPR. In various embodiments, the vectors comprise an operably linked nucleotide sequence which regulates the expression of GIPR. A vector can comprise or be associated with any suitable promoter, enhancer, and other expression-facilitating elements. Examples of such elements include strong expression promoters (e.g., a human CMV IE promoter/enhancer, an RSV promoter, SV40 promoter, SL3-3 promoter, MMTV promoter, or HIV LTR promoter, EF1alpha promoter, CAG promoter), effective poly (A) termination sequences, an origin of replication for plasmid product in E. coli, an antibiotic resistance gene as a selectable marker, and/or a convenient cloning site (e.g., a polylinker). Vectors also can comprise an inducible promoter as opposed to a constitutive promoter such as CMV IE. In one aspect, a nucleic acid comprising a sequence encoding a GIPR polypeptide which is operatively linked to a tissue specific promoter which promotes expression of the sequence in a metabolically-relevant tissue, such as liver or pancreatic tissue is provided.

In another aspect of the instant disclosure, host cells comprising the GIPR nucleic acids and vectors disclosed herein are provided. In various embodiments, the vector or nucleic acid is integrated into the host cell genome, which in other embodiments the vector or nucleic acid is extra-chromosomal.

Recombinant cells, such as yeast, bacterial (e.g., E. coli), and mammalian cells (e.g., immortalized mammalian cells) comprising such a nucleic acid, vector, or combinations of either or both thereof are provided. In various embodiments cells comprising a non-integrated nucleic acid, such as a plasmid, cosmid, phagemid, or linear expression element, which comprises a sequence coding for expression of a GIPR polypeptide, are provided.

A vector comprising a nucleic acid sequence encoding a GIPR polypeptide provided herein can be introduced into a host cell by transformation or by transfection. Methods of transforming a cell with an expression vector are well known.

A GIPR-encoding nucleic acid can be positioned in and/or delivered to a host cell or host animal via a viral vector. Any suitable viral vector can be used in this capacity. A viral vector can comprise any number of viral polynucleotides, alone or in combination with one or more viral proteins, which facilitate delivery, replication, and/or expression of the nucleic acid of the invention in a desired host cell. The viral vector can be a polynucleotide comprising all or part of a viral genome, a viral protein/nucleic acid conjugate, a virus-like particle (VLP), or an intact virus particle comprising viral nucleic acids and a GIPR polypeptide-encoding nucleic acid. A viral particle viral vector can comprise a wild-type viral particle or a modified viral particle. The viral vector can be a vector which requires the presence of another vector or wild-type virus for replication and/or expression (e.g., a viral vector can be a helper-dependent virus), such as an adenoviral vector amplicon. Typically, such viral vectors consist of a wild-type viral particle, or a viral particle modified in its protein and/or nucleic acid content to increase transgene capacity or aid in transfection and/or expression of the nucleic acid (examples of such vectors include the herpes virus/AAV amplicons). Typically, a viral vector is similar to and/or derived from a virus that normally infects humans. Suitable viral vector particles in this respect, include, for example, adenoviral vector particles (including any virus of or derived from a virus of the adenoviridae), adeno-associated viral vector particles (AAV vector particles) or other parvoviruses and parvoviral vector particles, papillomaviral vector particles, flaviviral vectors, alphaviral vectors, herpes viral vectors, pox virus vectors, retroviral vectors, including lentiviral vectors.

A GIPR polypeptide expressed as described herein can be isolated using standard protein purification methods. A GIPR polypeptide can be isolated from a cell in which is it naturally expressed or it can be isolated from a cell that has been engineered to express GIPR, for example a cell that does not naturally express GIPR.

Protein purification methods that can be employed to isolate a GIPR polypeptide, as well as associated materials and reagents, are known in the art. Additional purification methods that may be useful for isolating a GIPR polypeptide can be found in references such as Bootcov M R, 1997, Proc. Natl. Acad. Sci. USA 94:11514-9, Fairlie W D, 2000, Gene 254: 67-76.

Antagonist antigen binding proteins that bind GIPR, including human GIPR (hGIPR) are provided herein. In one embodiment, the human GIPR has the sequence as such as set forth in SEQ ID NO: 3141. In another embodiment, the human GIPR has the sequence as such set forth in SEQ ID NO: 3143. In another embodiment, the human GIPR has the sequence as such set forth in SEQ ID NO: 3145.

In one aspect the present invention is directed to a composition comprising an antibody or functional fragment thereof that specifically binds to human GIPR, wherein the antibody or functional fragment thereof comprises a cysteine or non-canonical amino acid amino acid substitution at one or more conjugation site(s); and a GLP-1 receptor agonist, wherein the GLP-1 receptor agonist is conjugated to the antibody or functional fragment thereof through the side-chain of the cysteine residue or non-canonical amino acid residue substituted at the one or more conjugation site(s).

The antigen binding proteins provided are polypeptides into which one or more complementary determining regions (CDRs), as described herein, are embedded and/or joined. In some antigen binding proteins, the CDRs are embedded into a “framework” region, which orients the CDR(s) such that the proper antigen binding properties of the CDR(s) are achieved. Certain antigen binding proteins described herein are antibodies or are derived from antibodies. In other antigen binding proteins, the CDR sequences are embedded in a different type of protein scaffold. The various structures are further described below.

The antigen binding proteins that are disclosed herein have a variety of utilities. The antigen binding proteins, for instance, are useful in specific binding assays, affinity purification of GIPR, and in screening assays to identify other antagonists of GIPR activity. Other uses for the antigen binding proteins include, for example, diagnosis of GIPR-associated diseases or conditions and screening assays to determine the presence or absence of GIPR. Given that the antigen binding proteins that are provided are antagonists, the GIPR antigen binding proteins have value in therapeutic methods in which it is useful to reduce weight gain, even while maintaining or increasing food intake, increasing % fat mass and increasing % lean mass, improving glucose tolerance, decreasing insulin levels, decreasing cholesterol and triglyceride levels. Accordingly, the antigen binding proteins have utility in the treatment and prevention of diabetes, e.g., type 2 diabetes, obesity, dyslipidemia, elevated glucose levels or elevated insulin levels.

A variety of selective binding agents useful for modulating the activity of GIPR are provided. These agents include, for instance, antigen binding proteins that contain an antigen binding domain (e.g., scFvs, domain antibodies, and polypeptides with an antigen binding region) and specifically bind to a GIPR polypeptide, in particular human GIPR. Some of the agents, for example, are useful in enhancing the activity of GIPR, and can activate one or more activities associated with GIPR.

In general the antigen binding proteins that are provided typically comprise one or more CDRs as described herein (e.g., 1, 2, 3, 4, 5 or 6). In some instances, the antigen binding protein comprises (a) a polypeptide structure and (b) one or more CDRs that are inserted into and/or joined to the polypeptide structure. The polypeptide structure can take a variety of different forms. For example, it can be, or comprise, the framework of a naturally occurring antibody, or fragment or variant thereof, or may be completely synthetic in nature. Examples of various polypeptide structures are further described below.

In certain embodiments, the polypeptide structure of the antigen binding proteins is an antibody or is derived from an antibody. Accordingly, examples of certain antigen binding proteins that are provided include, but are not limited to, monoclonal antibodies, bispecific antibodies, minibodies, domain antibodies such as Nanobodies®, synthetic antibodies (sometimes referred to herein as “antibody mimetics”), chimeric antibodies, humanized antibodies, human antibodies, antibody fusions, and portions or fragments of each, respectively. In some instances, the antigen binding protein is an immunological fragment of a complete antibody (e.g., a Fab, a Fab′, a F(ab′)2). In other instances the antigen binding protein is a scFv that uses CDRs from an antibody of the present invention.

The antigen binding proteins as provided herein specifically bind to a human GIPR. In a specific embodiment, the antigen binding protein specifically binds to human GIPR comprising or consisting of the amino acid sequence of SEQ ID NO: 3141. In a specific embodiment, the antigen binding protein specifically binds to human GIPR comprising or consisting of the amino acid sequence of SEQ ID NO: 3143. In a specific embodiment, the antigen binding protein specifically binds to human GIPR comprising or consisting of the amino acid sequence of SEQ ID NO: 3145.

The antigen binding proteins that are provided are antagonists and typically have one, two, three, four, five, six, seven or all eight of the following characteristics:

(a) ability to prevent or reduce binding of GIP to GIPR, where the levels can be measured, for example, by the methods such as radioactive- or fluorescence-labeled ligand binding study, or by the methods described herein (e.g. cAMP assay or other functional assays). The decrease can be at least 10, 25, 50, 100% or more relative to the pre-treatment levels of SEQ ID NO: 3141, 3143 or 3145 under comparable conditions.

(b) ability to decrease blood glucose;

(c) ability to increase glucose tolerance;

(d) ability to increase insulin sensitivity;

(e) ability to decrease body weight or reduce body weight gain;

(f) ability to decrease fat mass or decrease inflammation in fat tissue;

(g) ability to decrease fasting insulin levels;

(h) ability to decrease circulating cholesterol levels;

(i) ability to decrease circulating triglyceride levels;

(j) ability to decrease liver steatosis or reduce triglyceride level in liver;

(k) decrease AST, ALT, and/or ALP levels.

In one embodiment, a GIPR antigen binding protein has one or more of the following activities:

(a) binds human GIPR such that KD is ≤200 nM, is ≤150 nM, is ≤100 nM, is ≤50 nM, is ≤10 nM, is ≤5 nM, is ≤2 nM, or is ≤1 nM, e.g., as measured via a surface plasma resonance or kinetic exclusion assay technique.

(b) has a half-life in human serum of at least 3 days;

Some antigen binding proteins that are provided have an on-rate (ka) for GIPR of at least 10⁴/M×seconds, at least 10⁵/M×seconds, or at least 10⁶/M×seconds as measured, for instance, as described below. Certain antigen binding proteins that are provided have a slow dissociation rate or off-rate. Some antigen binding proteins, for instance, have a kd (off-rate) of 1×10⁻² s⁻¹, or 1×10⁻³ s⁻¹, or 1×10⁻⁴ s⁻¹, or 1×10⁻⁵ s⁻¹. In certain embodiments, the antigen binding protein has a KD (equilibrium binding affinity) of less than 25 pM, 50 pM, 100 pM, 500 pM, 1 nM, 5 nM, 10 nM, 25 nM or 50 nM.

In another aspect, an antigen-binding protein is provided having a half-life of at least one day in vitro or in vivo (e.g., when administered to a human subject). In one embodiment, the antigen binding protein has a half-life of at least three days. In various other embodiments, the antigen binding protein has a half-life of 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, 30, 40, 50, or 60 days or longer. In another embodiment, the antigen binding protein is derivatized or modified such that it has a longer half-life as compared to the underivatized or unmodified antibody. In another embodiment, the antigen binding protein contains point mutations to increase serum half-life. Further details regarding such mutant and derivatized forms are provided below.

Some of the antigen binding proteins that are provided have the structure typically associated with naturally occurring antibodies. The structural units of these antibodies typically comprise one or more tetramers, each composed of two identical couplets of polypeptide chains, though some species of mammals also produce antibodies having only a single heavy chain. In a typical antibody, each pair or couplet includes one full-length “light” chain (in certain embodiments, about 25 kDa) and one full-length “heavy” chain (in certain embodiments, about 50-70 kDa). Each individual immunoglobulin chain is composed of several “immunoglobulin domains”, each consisting of roughly 90 to 110 amino acids and expressing a characteristic folding pattern. These domains are the basic units of which antibody polypeptides are composed. The amino-terminal portion of each chain typically includes a variable domain that is responsible for antigen recognition. The carboxy-terminal portion is more conserved evolutionarily than the other end of the chain and is referred to as the “constant region” or “C region”. Human light chains generally are classified as kappa and lambda light chains, and each of these contains one variable domain and one constant domain. Heavy chains are typically classified as mu, delta, gamma, alpha, or epsilon chains, and these define the antibody's isotype as IgM, IgD, IgG, IgA, and IgE, respectively. IgG has several subtypes, including, but not limited to, IgG1, IgG2, IgG3, and IgG4. IgM subtypes include IgM, and IgM2. IgA subtypes include IgA1 and IgA2. In humans, the IgA and IgD isotypes contain four heavy chains and four light chains; the IgG and IgE isotypes contain two heavy chains and two light chains; and the IgM isotype contains five heavy chains and five light chains. The heavy chain C region typically comprises one or more domains that may be responsible for effector function. The number of heavy chain constant region domains will depend on the isotype. IgG heavy chains, for example, each contain three C region domains known as CH1, CH₂ and CH3. The antibodies that are provided can have any of these isotypes and subtypes. In certain embodiments, the GIPR antibody is of the IgG1, IgG2, or IgG4 subtype. The terms “GIPR antibody” and “anti-GIPR antibody” are used interchangeably throughout this application and figures. Both terms refer to an antibody that binds to GIPR.

In full-length light and heavy chains, the variable and constant regions are joined by a “J” region of about twelve or more amino acids, with the heavy chain also including a “D” region of about ten more amino acids. See, e.g. Fundamental Immunology, 2nd ed., Ch. 7 (Paul, W., ed.) 1989, New York: Raven Press (hereby incorporated by reference in its entirety for all purposes). The variable regions of each light/heavy chain pair typically form the antigen binding site.

For the antibodies provided herein, the variable regions of immunoglobulin chains generally exhibit the same overall structure, comprising relatively conserved framework regions (FR) joined by three hypervariable regions, more often called “complementarity determining regions” or CDRs. The CDRs from the two chains of each heavy chain/light chain pair mentioned above typically are aligned by the framework regions to form a structure that binds specifically with a specific epitope on GIPR. From N-terminal to C-terminal, naturally-occurring light and heavy chain variable regions both typically conform with the following order of these elements: FR1, CDR1, FR2, CDR2, FR3, CDR3 and FR4. A numbering system has been devised for assigning numbers to amino acids that occupy positions in each of these domains. This numbering system is defined in Kabat Sequences of Proteins of Immunological Interest (1987 and 1991, NIH, Bethesda, Md.), or Chothia & Lesk, 1987, J. Mol. Biol. 196:901-917; Chothia et al., 1989, Nature 342:878-883.

The sequence information for specific antibodies prepared and identified as described in the Examples below is summarized in TABLE 1. Thus, in an embodiment, an antigen binding protein is an antibody with the CDR, variable domain and light and heavy chain sequences as specified in one of the rows of TABLE 1.

SEQ ID NOs have been assigned to variable light chain, variable heavy chain, light chain, heavy chain, CDRL1, CDRL2, CDRL3, CDRH1, CDRH2, and CDRH3 sequences of the antibodies and fragments thereof of the present invention and are shown in TABLE 1. SEQ ID NOs have also been assigned to polynucleotides encoding the variable light chain, variable heavy chain, light chain, heavy chain, CDRL1, CDRL2, CDRL3, CDRH1, CDRH2, and CDRH3 sequences of the antibodies and fragments thereof of the present invention and are shown in TABLE 2. The antigen binding proteins of the present invention can be identified by SEQ ID NO, but also by construct name (e.g., 2C2.005) or identifier number (e.g., iPS:336175). The antigen binding proteins identified in Tables 1-5 below can be grouped into families based on construct name. For example, the “4B1 family” includes the constructs 4B1, 4B1.010, 4B1.011, 4B1.012, 4B1.013, 4B1.014, 4B1.015, and 4B1.016.

The various light chain and heavy chain variable regions provided herein are depicted in TABLE 3. Each of these variable regions may be attached to a heavy or light chain constant regions to form a complete antibody heavy and light chain, respectively. Furthermore, each of the so generated heavy and light chain sequences may be combined to form a complete antibody structure.

TABLE 1 Amino acid SEQ ID NOs. Identifier Construct VL VH LC HC CDRL1 CDRL2 CDRL3 CDRH1 CDRH2 CDRH3 iPS:336175 2C2.005 1 158 315 472 629 786 943 1100 1257 1414 iPS:335914 4B1 2 159 316 473 630 787 944 1101 1258 1415 iPS:335938 6H1 3 160 317 474 631 788 945 1102 1259 1416 iPS:335941 2F11 4 161 318 475 632 789 946 1103 1260 1417 iPS:335970 5C2 5 162 319 476 633 790 947 1104 1261 1418 iPS:335978 13H12 6 163 320 477 634 791 948 1105 1262 1419 iPS:335986 11C1 7 164 321 478 635 792 949 1106 1263 1420 iPS:335994 12H11 8 165 322 479 636 793 950 1107 1264 1421 iPS:336024 18E3 9 166 323 480 637 794 951 1108 1265 1422 iPS:336041 2G10_LC1 10 167 324 481 638 795 952 1109 1266 1423 iPS:336077 4H9.004 11 168 325 482 639 796 953 1110 1267 1424 iPS:336088 6A5.004 12 169 326 483 640 797 954 1111 1268 1425 iPS:336099 17H11.004 13 170 327 484 641 798 955 1112 1269 1426 iPS:359621 17H11.004.001 14 171 328 485 642 799 956 1113 1270 1427 iPS:359781 4H9.004.001 15 172 329 486 643 800 957 1114 1271 1428 iPS:360929 4H9.004.002 16 173 330 487 644 801 958 1115 1272 1429 iPS:360936 4H9.004.003 17 174 331 488 645 802 959 1116 1273 1430 iPS:360943 4H9.004.004 18 175 332 489 646 803 960 1117 1274 1431 iPS:360949 4H9.004.005 19 176 333 490 647 804 961 1118 1275 1432 iPS:359761 4H9.004.006 20 177 334 491 648 805 962 1119 1276 1433 iPS:360955 4B1.010 21 178 335 492 649 806 963 1120 1277 1434 iPS:360962 4B1.011 22 179 336 493 650 807 964 1121 1278 1435 iPS:360968 4B1.012 23 180 337 494 651 808 965 1122 1279 1436 iPS:360974 4B1.013 24 181 338 495 652 809 966 1123 1280 1437 iPS:360978 4B1.014 25 182 339 496 653 810 967 1124 1281 1438 iPS:359785 4B1.015 26 183 340 497 654 811 968 1125 1282 1439 iPS:360982 4B1.016 27 184 341 498 655 812 969 1126 1283 1440 iPS:335922 18F2 28 185 342 499 656 813 970 1127 1284 1441 iPS:360986 18F2.002 29 186 343 500 657 814 971 1128 1285 1442 iPS:360995 18F2.003 30 187 344 501 658 815 972 1129 1286 1443 iPS:360999 18F2.004 31 188 345 502 659 816 973 1130 1287 1444 iPS:361005 18F2.005 32 189 346 503 660 817 974 1131 1288 1445 iPS:361009 18F2.006 33 190 347 504 661 818 975 1132 1289 1446 iPS:361013 18F2.007 34 191 348 505 662 819 976 1133 1290 1447 iPS:361017 18F2.008 35 192 349 506 663 820 977 1134 1291 1448 iPS:361021 18F2.009 36 193 350 507 664 821 978 1135 1292 1449 iPS:361028 18F2.010 37 194 351 508 665 822 979 1136 1293 1450 iPS:360535 18F2.011 38 195 352 509 666 823 980 1137 1294 1451 iPS:361035 18F2.012 39 196 353 510 667 824 981 1138 1295 1452 iPS:359940 2F11.002 40 197 354 511 668 825 982 1139 1296 1453 iPS:361039 2F11.003 41 198 355 512 669 826 983 1140 1297 1454 iPS:361043 2F11.004 42 199 356 513 670 827 984 1141 1298 1455 iPS:361049 2F11.005 43 200 357 514 671 828 985 1142 1299 1456 iPS:361055 2F11.006 44 201 358 515 672 829 986 1143 1300 1457 iPS:361059 2F11.007 45 202 359 516 673 830 987 1144 1301 1458 iPS:361063 2F11.008 46 203 360 517 674 831 988 1145 1302 1459 iPS:359949 2F11.009 47 204 361 518 675 832 989 1146 1303 1460 iPS:359956 2F11.010 48 205 362 519 676 833 990 1147 1304 1461 iPS:359865 6H1.002 49 206 363 520 677 834 991 1148 1305 1462 iPS:359869 6H1.003 50 207 364 521 678 835 992 1149 1306 1463 iPS:359873 6H1.004 51 208 365 522 679 836 993 1150 1307 1464 iPS:359877 6H1.005 52 209 366 523 680 837 994 1151 1308 1465 iPS:361067 6H1.006 53 210 367 524 681 838 995 1152 1309 1466 iPS:361071 6H1.007 54 211 368 525 682 839 996 1153 1310 1467 iPS:361075 6H1.008 55 212 369 526 683 840 997 1154 1311 1468 iPS:361079 6A5.004.001 56 213 370 527 684 841 998 1155 1312 1469 iPS:361085 6A5.004.002 57 214 371 528 685 842 999 1156 1313 1470 iPS:361091 6A5.004.003 58 215 372 529 686 843 1000 1157 1314 1471 iPS:361095 6A5.004.004 59 216 373 530 687 844 1001 1158 1315 1472 iPS:361101 6A5.004.005 60 217 374 531 688 845 1002 1159 1316 1473 iPS:361105 6A5.004.006 61 218 375 532 689 846 1003 1160 1317 1474 iPS:361109 6A5.004.007 62 219 376 533 690 847 1004 1161 1318 1475 iPS:361113 6A5.004.008 63 220 377 534 691 848 1005 1162 1319 1476 iPS:361120 6A5.004.009 64 221 378 535 692 849 1006 1163 1320 1477 iPS:359896 6A5.004.010 65 222 379 536 693 850 1007 1164 1321 1478 iPS:359890 6A5.004.011 66 223 380 537 694 851 1008 1165 1322 1479 iPS:359567 2A11.002 67 224 381 538 695 852 1009 1166 1323 1480 iPS:335965 2A11.003 68 225 382 539 696 853 1010 1167 1324 1481 iPS:361158 2A11.004 69 226 383 540 697 854 1011 1168 1325 1482 iPS:361165 2A11.005 70 227 384 541 698 855 1012 1169 1326 1483 iPS:361172 2G10_LC1.003 71 228 385 542 699 856 1013 1170 1327 1484 iPS:361178 2G10_LC1.004 72 229 386 543 700 857 1014 1171 1328 1485 iPS:361185 2G10_LC1.005 73 230 387 544 701 858 1015 1172 1329 1486 iPS:361192 2G10_LC1.006 74 231 388 545 702 859 1016 1173 1330 1487 iPS:359609 2G10_LC1.007 75 232 389 546 703 860 1017 1174 1331 1488 iPS:359615 2G10_LC1.008 76 233 390 547 704 861 1018 1175 1332 1489 iPS:361196 2G10_LC1.009 77 234 391 548 705 862 1019 1176 1333 1490 iPS:361202 2G10_LC1.010 78 235 392 549 706 863 1020 1177 1334 1491 iPS:359644 18E3.002 79 236 393 550 707 864 1021 1178 1335 1492 iPS:361206 18E3.003 80 237 394 551 708 865 1022 1179 1336 1493 iPS:359628 18E3.004 81 238 395 552 709 866 1023 1180 1337 1494 iPS:359637 18E3.005 82 239 396 553 710 867 1024 1181 1338 1495 iPS:361210 18E3.006 83 240 397 554 711 868 1025 1182 1339 1496 iPS:361214 18E3.007 84 241 398 555 712 869 1026 1183 1340 1497 iPS:361218 18E3.008 85 242 399 556 713 870 1027 1184 1341 1498 iPS:361222 5C2.006 86 243 400 557 714 871 1028 1185 1342 1499 iPS:361229 5C2.007 87 244 401 558 715 872 1029 1186 1343 1500 iPS:361236 5C2.008 88 245 402 559 716 873 1030 1187 1344 1501 iPS:359685 5C2.009 89 246 403 560 717 874 1031 1188 1345 1502 iPS:361240 5C2.010 90 247 404 561 718 875 1032 1189 1346 1503 iPS:361247 5C2.011 91 248 405 562 719 876 1033 1190 1347 1504 iPS:361254 5C2.012 92 249 406 563 720 877 1034 1191 1348 1505 iPS:361261 5C2.013 93 250 407 564 721 878 1035 1192 1349 1506 iPS:361268 5C2.014 94 251 408 565 722 879 1036 1193 1350 1507 iPS:359669 5C2.015 95 252 409 566 723 880 1037 1194 1351 1508 iPS:359678 5C2.016 96 253 410 567 724 881 1038 1195 1352 1509 iPS:361275 11C1.002 97 254 411 568 725 882 1039 1196 1353 1510 iPS:361282 11C1.003 98 255 412 569 726 883 1040 1197 1354 1511 iPS:361289 11C1.004 99 256 413 570 727 884 1041 1198 1355 1512 iPS:359712 11C1.005 100 257 414 571 728 885 1042 1199 1356 1513 iPS:361293 11C1.006 101 258 415 572 729 886 1043 1200 1357 1514 iPS:361297 11C1.007 102 259 416 573 730 887 1044 1201 1358 1515 iPS:361301 11C1.008 103 260 417 574 731 888 1045 1202 1359 1516 iPS:359703 11C1.009 104 261 418 575 732 889 1046 1203 1360 1517 iPS:361305 11C1.010 105 262 419 576 733 890 1047 1204 1361 1518 iPS:361312 13H12.002 106 263 420 577 734 891 1048 1205 1362 1519 iPS:359744 13H12.003 107 264 421 578 735 892 1049 1206 1363 1520 iPS:361319 13H12.004 108 265 422 579 736 893 1050 1207 1364 1521 iPS:359737 13H12.005 109 266 423 580 737 894 1051 1208 1365 1522 iPS:361326 13H12.006 110 267 424 581 738 895 1052 1209 1366 1523 iPS:361330 12H11.002 111 268 425 582 739 896 1053 1210 1367 1524 iPS:361337 12H11.003 112 269 426 583 740 897 1054 1211 1368 1525 iPS:361344 12H11.004 113 270 427 584 741 898 1055 1212 1369 1526 iPS:361351 12H11.005 114 271 428 585 742 899 1056 1213 1370 1527 iPS:361358 12H11.006 115 272 429 586 743 900 1057 1214 1371 1528 iPS:361365 12H11.007 116 273 430 587 744 901 1058 1215 1372 1529 iPS:361372 12H11.008 117 274 431 588 745 902 1059 1216 1373 1530 iPS:361379 12H11.009 118 275 432 589 746 903 1060 1217 1374 1531 iPS:361383 12H11.010 119 276 433 590 747 904 1061 1218 1375 1532 iPS:361387 12H11.011 120 277 434 591 748 905 1062 1219 1376 1533 iPS:361391 12H11.012 121 278 435 592 749 906 1063 1220 1377 1534 iPS:361395 12H11.013 122 279 436 593 750 907 1064 1221 1378 1535 iPS:361402 12H11.014 123 280 437 594 751 908 1065 1222 1379 1536 iPS:361406 2C2.005.001 124 281 438 595 752 909 1066 1223 1380 1537 iPS:361412 2C2.005.002 125 282 439 596 753 910 1067 1224 1381 1538 iPS:361418 2C2.005.003 126 283 440 597 754 911 1068 1225 1382 1539 iPS:361424 2C2.005.004 127 284 441 598 755 912 1069 1226 1383 1540 iPS:361430 2C2.005.005 128 285 442 599 756 913 1070 1227 1384 1541 iPS:361436 2C2.005.006 129 286 443 600 757 914 1071 1228 1385 1542 iPS:361442 2C2.005.007 130 287 444 601 758 915 1072 1229 1386 1543 iPS:361448 2C2.005.008 131 288 445 602 759 916 1073 1230 1387 1544 iPS:361454 2C2.005.009 132 289 446 603 760 917 1074 1231 1388 1545 iPS:361460 2C2.005.010 133 290 447 604 761 918 1075 1232 1389 1546 iPS:361466 2C2.005.011 134 291 448 605 762 919 1076 1233 1390 1547 iPS:361472 2C2.005.012 135 292 449 606 763 920 1077 1234 1391 1548 iPS:361478 2C2.005.013 136 293 450 607 764 921 1078 1235 1392 1549 iPS:361485 2C2.005.014 137 294 451 608 765 922 1079 1236 1393 1550 iPS:361845 18F2.013 138 295 452 609 766 923 1080 1237 1394 1551 iPS:361851 6H1.009 139 296 453 610 767 924 1081 1238 1395 1552 iPS:361855 2C2.005.015 140 297 454 611 768 925 1082 1239 1396 1553 iPS:336067 5G12.006 141 298 455 612 769 926 1083 1240 1397 1554 iPS:336169 17B11.002 142 299 456 613 770 927 1084 1241 1398 1555 iPS:361127 5G12.006.001 143 300 457 614 771 928 1085 1242 1399 1556 iPS:361136 5G12.006.002 144 301 458 615 772 929 1086 1243 1400 1557 iPS:361140 5G12.006.003 145 302 459 616 773 930 1087 1244 1401 1558 iPS:359919 5G12.006.004 146 303 460 617 774 931 1088 1245 1402 1559 iPS:361144 5G12.006.005 147 304 461 618 775 932 1089 1246 1403 1560 iPS:361151 5G12.006.006 148 305 462 619 776 933 1090 1247 1404 1561 iPS:361491 17B11.002.001 149 306 463 620 777 934 1091 1248 1405 1562 iPS:361499 17B11.002.002 150 307 464 621 778 935 1092 1249 1406 1563 iPS:361503 17B11.002.003 151 308 465 622 779 936 1093 1250 1407 1564 iPS:361507 17B11.002.004 152 309 466 623 780 937 1094 1251 1408 1565 iPS:361514 17B11.002.005 153 310 467 624 781 938 1095 1252 1409 1566 iPS:360582 17B11.002.006 154 311 468 625 782 939 1096 1253 1410 1567 iPS:361518 17B11.002.007 155 312 469 626 783 940 1097 1254 1411 1568 iPS:360570 17B11.002.008 156 313 470 627 784 941 1098 1255 1412 1569 iPS:362051 5G12.005.001 157 314 471 628 785 942 1099 1256 1413 1570

TABLE 2 Nucleic acid SEQ ID NOs. Identifier Construct VL VH LC HC CDRL1 CDRL2 CDRL3 CDRH1 CDRH2 CDRH3 iPS:336175 2C2.005 1571 1728 1885 2042 2199 2356 2513 2670 2827 2984 iPS:335914 4B1 1572 1729 1886 2043 2200 2357 2514 2671 2828 2985 iPS:335938 6H1 1573 1730 1887 2044 2201 2358 2515 2672 2829 2986 iPS:335941 2F11 1574 1731 1888 2045 2202 2359 2516 2673 2830 2987 iPS:335970 5C2 1575 1732 1889 2046 2203 2360 2517 2674 2831 2988 iPS:335978 13H12 1576 1733 1890 2047 2204 2361 2518 2675 2832 2989 iPS:335986 11C1 1577 1734 1891 2048 2205 2362 2519 2676 2833 2990 iPS:335994 12H11 1578 1735 1892 2049 2206 2363 2520 2677 2834 2991 iPS:336024 18E3 1579 1736 1893 2050 2207 2364 2521 2678 2835 2992 iPS:336041 2G10_LC1 1580 1737 1894 2051 2208 2365 2522 2679 2836 2993 iPS:336077 4H9.004 1581 1738 1895 2052 2209 2366 2523 2680 2837 2994 iPS:336088 6A5.004 1582 1739 1896 2053 2210 2367 2524 2681 2838 2995 iPS:336099 17H11.004 1583 1740 1897 2054 2211 2368 2525 2682 2839 2996 iPS:359621 17H11.004.001 1584 1741 1898 2055 2212 2369 2526 2683 2840 2997 iPS:359781 4H9.004.001 1585 1742 1899 2056 2213 2370 2527 2684 2841 2998 iPS:360929 4H9.004.002 1586 1743 1900 2057 2214 2371 2528 2685 2842 2999 iPS:360936 4H9.004.003 1587 1744 1901 2058 2215 2372 2529 2686 2843 3000 iPS:360943 4H9.004.004 1588 1745 1902 2059 2216 2373 2530 2687 2844 3001 iPS:360949 4H9.004.005 1589 1746 1903 2060 2217 2374 2531 2688 2845 3002 iPS:359761 4H9.004.006 1590 1747 1904 2061 2218 2375 2532 2689 2846 3003 iPS:360955 4B1.010 1591 1748 1905 2062 2219 2376 2533 2690 2847 3004 iPS:360962 4B1.011 1592 1749 1906 2063 2220 2377 2534 2691 2848 3005 iPS:360968 4B1.012 1593 1750 1907 2064 2221 2378 2535 2692 2849 3006 iPS:360974 4B1.013 1594 1751 1908 2065 2222 2379 2536 2693 2850 3007 iPS:360978 4B1.014 1595 1752 1909 2066 2223 2380 2537 2694 2851 3008 iPS:359785 4B1.015 1596 1753 1910 2067 2224 2381 2538 2695 2852 3009 iPS:360982 4B1.016 1597 1754 1911 2068 2225 2382 2539 2696 2853 3010 iPS:335922 18F2 1598 1755 1912 2069 2226 2383 2540 2697 2854 3011 iPS:360986 18F2.002 1599 1756 1913 2070 2227 2384 2541 2698 2855 3012 iPS:360995 18F2.003 1600 1757 1914 2071 2228 2385 2542 2699 2856 3013 iPS:360999 18F2.004 1601 1758 1915 2072 2229 2386 2543 2700 2857 3014 iPS:361005 18F2.005 1602 1759 1916 2073 2230 2387 2544 2701 2858 3015 iPS:361009 18F2.006 1603 1760 1917 2074 2231 2388 2545 2702 2859 3016 iPS:361013 18F2.007 1604 1761 1918 2075 2232 2389 2546 2703 2860 3017 iPS:361017 18F2.008 1605 1762 1919 2076 2233 2390 2547 2704 2861 3018 iPS:361021 18F2.009 1606 1763 1920 2077 2234 2391 2548 2705 2862 3019 iPS:361028 18F2.010 1607 1764 1921 2078 2235 2392 2549 2706 2863 3020 iPS:360535 18F2.011 1608 1765 1922 2079 2236 2393 2550 2707 2864 3021 iPS:361035 18F2.012 1609 1766 1923 2080 2237 2394 2551 2708 2865 3022 iPS:359940 2F11.002 1610 1767 1924 2081 2238 2395 2552 2709 2866 3023 iPS:361039 2F11.003 1611 1768 1925 2082 2239 2396 2553 2710 2867 3024 iPS:361043 2F11.004 1612 1769 1926 2083 2240 2397 2554 2711 2868 3025 iPS:361049 2F11.005 1613 1770 1927 2084 2241 2398 2555 2712 2869 3026 iPS:361055 2F11.006 1614 1771 1928 2085 2242 2399 2556 2713 2870 3027 iPS:361059 2F11.007 1615 1772 1929 2086 2243 2400 2557 2714 2871 3028 iPS:361063 2F11.008 1616 1773 1930 2087 2244 2401 2558 2715 2872 3029 iPS:359949 2F11.009 1617 1774 1931 2088 2245 2402 2559 2716 2873 3030 iPS:359956 2F11.010 1618 1775 1932 2089 2246 2403 2560 2717 2874 3031 iPS:359865 6H1.002 1619 1776 1933 2090 2247 2404 2561 2718 2875 3032 iPS:359869 6H1.003 1620 1777 1934 2091 2248 2405 2562 2719 2876 3033 iPS:359873 6H1.004 1621 1778 1935 2092 2249 2406 2563 2720 2877 3034 iPS:359877 6H1.005 1622 1779 1936 2093 2250 2407 2564 2721 2878 3035 iPS:361067 6H1.006 1623 1780 1937 2094 2251 2408 2565 2722 2879 3036 iPS:361071 6H1.007 1624 1781 1938 2095 2252 2409 2566 2723 2880 3037 iPS:361075 6H1.008 1625 1782 1939 2096 2253 2410 2567 2724 2881 3038 iPS:361079 6A5.004.001 1626 1783 1940 2097 2254 2411 2568 2725 2882 3039 iPS:361085 6A5.004.002 1627 1784 1941 2098 2255 2412 2569 2726 2883 3040 iPS:361091 6A5.004.003 1628 1785 1942 2099 2256 2413 2570 2727 2884 3041 iPS:361095 6A5.004.004 1629 1786 1943 2100 2257 2414 2571 2728 2885 3042 iPS:361101 6A5.004.005 1630 1787 1944 2101 2258 2415 2572 2729 2886 3043 iPS:361105 6A5.004.006 1631 1788 1945 2102 2259 2416 2573 2730 2887 3044 iPS:361109 6A5.004.007 1632 1789 1946 2103 2260 2417 2574 2731 2888 3045 iPS:361113 6A5.004.008 1633 1790 1947 2104 2261 2418 2575 2732 2889 3046 iPS:361120 6A5.004.009 1634 1791 1948 2105 2262 2419 2576 2733 2890 3047 iPS:359896 6A5.004.010 1635 1792 1949 2106 2263 2420 2577 2734 2891 3048 iPS:359890 6A5.004.011 1636 1793 1950 2107 2264 2421 2578 2735 2892 3049 iPS:359567 2A11.002 1637 1794 1951 2108 2265 2422 2579 2736 2893 3050 iPS:335965 2A11.003 1638 1795 1952 2109 2266 2423 2580 2737 2894 3051 iPS:361158 2A11.004 1639 1796 1953 2110 2267 2424 2581 2738 2895 3052 iPS:361165 2A11.005 1640 1797 1954 2111 2268 2425 2582 2739 2896 3053 iPS:361172 2G10_LC1.003 1641 1798 1955 2112 2269 2426 2583 2740 2897 3054 iPS:361178 2G10_LC1.004 1642 1799 1956 2113 2270 2427 2584 2741 2898 3055 iPS:361185 2G10_LC1.005 1643 1800 1957 2114 2271 2428 2585 2742 2899 3056 iPS:361192 2G10_LC1.006 1644 1801 1958 2115 2272 2429 2586 2743 2900 3057 iPS:359609 2G10_LC1.007 1645 1802 1959 2116 2273 2430 2587 2744 2901 3058 iPS:359615 2G10_LC1.008 1646 1803 1960 2117 2274 2431 2588 2745 2902 3059 iPS:361196 2G10_LC1.009 1647 1804 1961 2118 2275 2432 2589 2746 2903 3060 iPS:361202 2G10_LC1.010 1648 1805 1962 2119 2276 2433 2590 2747 2904 3061 iPS:359644 18E3.002 1649 1806 1963 2120 2277 2434 2591 2748 2905 3062 iPS:361206 18E3.003 1650 1807 1964 2121 2278 2435 2592 2749 2906 3063 iPS:359628 18E3.004 1651 1808 1965 2122 2279 2436 2593 2750 2907 3064 iPS:359637 18E3.005 1652 1809 1966 2123 2280 2437 2594 2751 2908 3065 iPS:361210 18E3.006 1653 1810 1967 2124 2281 2438 2595 2752 2909 3066 iPS:361214 18E3.007 1654 1811 1968 2125 2282 2439 2596 2753 2910 3067 iPS:361218 18E3.008 1655 1812 1969 2126 2283 2440 2597 2754 2911 3068 iPS:361222 5C2.006 1656 1813 1970 2127 2284 2441 2598 2755 2912 3069 iPS:361229 5C2.007 1657 1814 1971 2128 2285 2442 2599 2756 2913 3070 iPS:361236 5C2.008 1658 1815 1972 2129 2286 2443 2600 2757 2914 3071 iPS:359685 5C2.009 1659 1816 1973 2130 2287 2444 2601 2758 2915 3072 iPS:361240 5C2.010 1660 1817 1974 2131 2288 2445 2602 2759 2916 3073 iPS:361247 5C2.011 1661 1818 1975 2132 2289 2446 2603 2760 2917 3074 iPS:361254 5C2.012 1662 1819 1976 2133 2290 2447 2604 2761 2918 3075 iPS:361261 5C2.013 1663 1820 1977 2134 2291 2448 2605 2762 2919 3076 iPS:361268 5C2.014 1664 1821 1978 2135 2292 2449 2606 2763 2920 3077 iPS:359669 5C2.015 1665 1822 1979 2136 2293 2450 2607 2764 2921 3078 iPS:359678 5C2.016 1666 1823 1980 2137 2294 2451 2608 2765 2922 3079 iPS:361275 11C1.002 1667 1824 1981 2138 2295 2452 2609 2766 2923 3080 iPS:361282 11C1.003 1668 1825 1982 2139 2296 2453 2610 2767 2924 3081 iPS:361289 11C1.004 1669 1826 1983 2140 2297 2454 2611 2768 2925 3082 iPS:359712 11C1.005 1670 1827 1984 2141 2298 2455 2612 2769 2926 3083 iPS:361293 11C1.006 1671 1828 1985 2142 2299 2456 2613 2770 2927 3084 iPS:361297 11C1.007 1672 1829 1986 2143 2300 2457 2614 2771 2928 3085 iPS:361301 11C1.008 1673 1830 1987 2144 2301 2458 2615 2772 2929 3086 iPS:359703 11C1.009 1674 1831 1988 2145 2302 2459 2616 2773 2930 3087 iPS:361305 11C1.010 1675 1832 1989 2146 2303 2460 2617 2774 2931 3088 iPS:361312 13H12.002 1676 1833 1990 2147 2304 2461 2618 2775 2932 3089 iPS:359744 13H12.003 1677 1834 1991 2148 2305 2462 2619 2776 2933 3090 iPS:361319 13H12.004 1678 1835 1992 2149 2306 2463 2620 2777 2934 3091 iPS:359737 13H12.005 1679 1836 1993 2150 2307 2464 2621 2778 2935 3092 iPS:361326 13H12.006 1680 1837 1994 2151 2308 2465 2622 2779 2936 3093 iPS:361330 12H11.002 1681 1838 1995 2152 2309 2466 2623 2780 2937 3094 iPS:361337 12H11.003 1682 1839 1996 2153 2310 2467 2624 2781 2938 3095 iPS:361344 12H11.004 1683 1840 1997 2154 2311 2468 2625 2782 2939 3096 iPS:361351 12H11.005 1684 1841 1998 2155 2312 2469 2626 2783 2940 3097 iPS:361358 12H11.006 1685 1842 1999 2156 2313 2470 2627 2784 2941 3098 iPS:361365 12H11.007 1686 1843 2000 2157 2314 2471 2628 2785 2942 3099 iPS:361372 12H11.008 1687 1844 2001 2158 2315 2472 2629 2786 2943 3100 iPS:361379 12H11.009 1688 1845 2002 2159 2316 2473 2630 2787 2944 3101 iPS:361383 12H11.010 1689 1846 2003 2160 2317 2474 2631 2788 2945 3102 iPS:361387 12H11.011 1690 1847 2004 2161 2318 2475 2632 2789 2946 3103 iPS:361391 12H11.012 1691 1848 2005 2162 2319 2476 2633 2790 2947 3104 iPS:361395 12H11.013 1692 1849 2006 2163 2320 2477 2634 2791 2948 3105 iPS:361402 12H11.014 1693 1850 2007 2164 2321 2478 2635 2792 2949 3106 iPS:361406 2C2.005.001 1694 1851 2008 2165 2322 2479 2636 2793 2950 3107 iPS:361412 2C2.005.002 1695 1852 2009 2166 2323 2480 2637 2794 2951 3108 iPS:361418 2C2.005.003 1696 1853 2010 2167 2324 2481 2638 2795 2952 3109 iPS:361424 2C2.005.004 1697 1854 2011 2168 2325 2482 2639 2796 2953 3110 iPS:361430 2C2.005.005 1698 1855 2012 2169 2326 2483 2640 2797 2954 3111 iPS:361436 2C2.005.006 1699 1856 2013 2170 2327 2484 2641 2798 2955 3112 iPS:361442 2C2.005.007 1700 1857 2014 2171 2328 2485 2642 2799 2956 3113 iPS:361448 2C2.005.008 1701 1858 2015 2172 2329 2486 2643 2800 2957 3114 iPS:361454 2C2.005.009 1702 1859 2016 2173 2330 2487 2644 2801 2958 3115 iPS:361460 2C2.005.010 1703 1860 2017 2174 2331 2488 2645 2802 2959 3116 iPS:361466 2C2.005.011 1704 1861 2018 2175 2332 2489 2646 2803 2960 3117 iPS:361472 2C2.005.012 1705 1862 2019 2176 2333 2490 2647 2804 2961 3118 iPS:361478 2C2.005.013 1706 1863 2020 2177 2334 2491 2648 2805 2962 3119 iPS:361485 2C2.005.014 1707 1864 2021 2178 2335 2492 2649 2806 2963 3120 iPS:361845 18F2.013 1708 1865 2022 2179 2336 2493 2650 2807 2964 3121 iPS:361851 6H1.009 1709 1866 2023 2180 2337 2494 2651 2808 2965 3122 iPS:361855 2C2.005.015 1710 1867 2024 2181 2338 2495 2652 2809 2966 3123 iPS:336067 5G12.006 1711 1868 2025 2182 2339 2496 2653 2810 2967 3124 iPS:336169 17B11.002 1712 1869 2026 2183 2340 2497 2654 2811 2968 3125 iPS:361127 5G12.006.001 1713 1870 2027 2184 2341 2498 2655 2812 2969 3126 iPS:361136 5G12.006.002 1714 1871 2028 2185 2342 2499 2656 2813 2970 3127 iPS:361140 5G12.006.003 1715 1872 2029 2186 2343 2500 2657 2814 2971 3128 iPS:359919 5G12.006.004 1716 1873 2030 2187 2344 2501 2658 2815 2972 3129 iPS:361144 5G12.006.005 1717 1874 2031 2188 2345 2502 2659 2816 2973 3130 iPS:361151 5G12.006.006 1718 1875 2032 2189 2346 2503 2660 2817 2974 3131 iPS:361491 17B11.002.001 1719 1876 2033 2190 2347 2504 2661 2818 2975 3132 iPS:361499 17B11.002.002 1720 1877 2034 2191 2348 2505 2662 2819 2976 3133 iPS:361503 17B11.002.003 1721 1878 2035 2192 2349 2506 2663 2820 2977 3134 iPS:361507 17B11.002.004 1722 1879 2036 2193 2350 2507 2664 2821 2978 3135 iPS:361514 17B11.002.005 1723 1880 2037 2194 2351 2508 2665 2822 2979 3136 iPS:360582 17B11.002.006 1724 1881 2038 2195 2352 2509 2666 2823 2980 3137 iPS:361518 17B11.002.007 1725 1882 2039 2196 2353 2510 2667 2824 2981 3138 iPS:360570 17B11.002.008 1726 1883 2040 2197 2354 2511 2668 2825 2982 3139 iPS:362051 5G12.005.001 1727 1884 2041 2198 2355 2512 2669 2826 2983 3140

TABLE 3 Exemplary Variable Light and Variable Heavy Regions: Nucleic Acid (“NA”) and Amino Acid (“AA”) Sequences iPS:  # Ab Type VL VH iPS: 336175 2C2.005 NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGTAGCTCCAACATCGGAAGTAATACTG AAGGCTTCCGGATACACCTTCACCGGCTACTAT TAAACTGGTACCAGCACCTCCCAGGAACGGCCC ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATCTATACTAATAATCAGCGGC CTTGAGTGGATGGGATGGATCAACCCTAACAGT CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GGTGGCACAAACTATGCACAGAAGTTTCAGGGC GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG AGGGTCACCATGACCAGGGACACGTCCATCAGT CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT CAACATTCGATGACAGCCTGAATGGTCCGGTAT GACGACACGGCCGTGTATTACTGTGCGAGAGGG TCGGCGGAGGGACCAAGCTGACCGTCCTAGGT GGGGATTACGTTTGGGGGACTTATCGGCCTCAC SEQ ID NO: 1571 TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCA SEQ ID NO: 1728 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNW QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ ASLAISGLQSEDEADYFCATFDDSLNGPVFGGGTK GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG LTVLG GDYVWGTYRPHYYYGMDVWGQGTTVTVSS SEQ ID NO: 1 SEQ ID NO: 158 iPS: 335914 4B1 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGGAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACTCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAATA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCACATGAACAGCCTGAGAGTCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT CGGACACGGCTGTGTATTATTGTGCGCGAGATG GGGACCAAAGTGGATATCAAACGA GGACGATCTTTGGAGTGGTCTTGGGGGACTACT SEQ ID NO: 1572 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1729 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM QQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTEFT HWVRQAPGKGLEWVAVIWYDGSNENYADSVKG LTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDIKR RFTISRDNSKNTLYLHMNSLRVADTAVYYCARDG SEQ ID NO: 2 TIFGVVLGDYWGQGTLVTVSS SEQ ID NO: 159 iPS: 335938 6H1 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGGAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATAAATACTATGCAGACTCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGGACCAAAGTGGATATCAAACGA GGACGATTTTTGGAGTGCTCTTGGGGGACTACT SEQ ID NO: 1573 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1730 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM QQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTEFT HWVRQAPGKGLEWVAVIWYDGSNKYYADSVKG LTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDIKR RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG SEQ ID NO: 3 TIFGVLLGDYWGQGTLVTVSS SEQ ID NO: 160 iPS: 335941 2F11 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTACGATGCATCCAATTTGGAAA CTGGAGTGGGTGGCAGTTATATGGTATGATGGA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT AGTAATAAATACTATGCAGACTCCGTGAAGGGC CTGGGACAGATTTTAGTTTCACCATCAGCAGCCT CGATTCACCATCTCCAGCGACAATTCCAAGAAC GCAGCCTGAAGATATTGCAACATATTACTGTCA ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC ACAGTATGATATTCTCCTCACTTTCGGCGGAGG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GACCAAGGTGGAGATCAAGCGA AGGACGATTTTTGGAGTGGTTCTTGACTACTGG SEQ ID NO: 1574 GGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1731 AA DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD HWVRQAPGKGLEWVAVIWYDGSNKYYADSVKG FSFTISSLQPEDIATYYCQQYDILLTFGGGTKVEIK RFTISSDNSKNTLYLQMNSLRAEDTAVYYCARDR R TIFGVVLDYWGQGTLVTVSS SEQ ID NO: 4 SEQ ID NO: 161 iPS: 335970 5C2 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT CTTGAGTGGATGGGGTGGATCAACCCTGACAGT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA AGGTTCACCATGACCAGGGACACGTCCATCAGC CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG ACAGCCTACATGGAACTGAACAGGCTGAGATCT TGGCAGTTTTTTACTGTCAACAATATTATAGTAC GACGACACGGCCGTGTATTACTGTGCGAGAGAG TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1575 CCTCA SEQ ID NO: 1732 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPDSGGTDYSQRFQGR GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ FTMTRDTSISTAYMELNRLRSDDTAVYYCAREATI GTKVEIKR FGMVIVPFDYWGQGTLVTVSS SEQ ID NO: 5 SEQ ID NO: 162 iPS: 335978 13H12 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGA AAACCAGGACATCCTCCTAAGCTGCTCATTTACT CTTGAGTGGATGGGGTGGATCAACCCTGACAGT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA AGGTTCACCATGACCAGGGACACGTCCATCAGC CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG ACAGCCTACATGGAACTGAGCAGGCTGAGATCT TGGCAGTTTTTTACTGTCAACAATATTATAGTAC GACGACACGGCCGTGTATTACTGTGCGAGAGAG TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1576 CCTCA SEQ ID NO: 1733 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQKPGHPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPDSGGTDYSQRFQGR GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ FTMTRDTSISTAYMELSRLRSDDTAVYYCAREATI GTKVEIKR FGMVIVPFDYWGQGTLVTVSS SEQ ID NO: 6 SEQ ID NO: 163 iPS: 335986 11C1 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTACAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAACAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGTGTGGATGGGGTGGATCAGCCCTAACAGT TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC GGTGACACAAGCTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTTCTGTACGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1577 CCTCA SEQ ID NO: 1734 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG HWVRQAPGQGLVWMGWISPNSGDTSYAQKFQDR SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF VTMTRDTSISTAYMELSRLRSDDTAVYFCTREATI GQGTKVEIKR FGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 7 SEQ ID NO: 164 iPS: 335994 12H11 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAGCAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGAGTGGATGGGGTGGATAAGCCCTAACAAT TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC GGTGACACAAACTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTACTGTACGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1578 CCTCA SEQ ID NO: 1735 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG HWVRQAPGQGLEWMGWISPNNGDTNYAQKFQD SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF RVTMTRDTSISTAYMELSRLRSDDTAVYYCTREA GQGTKVEIKR TIFGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 8 SEQ ID NO: 165 iPS:336024 18E3 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG CAGGTGCAGTTGCAGGAGTCGGGCCCAGGACTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GTGAAGCCTTCACAGACCCTGTCCCTCACCTGC GCAGGGCCAGTCAGAGTATTAGTTACAGTTACT ACTGTCTCTGGTGACTCCATCAGCAGTGGTGGTT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC ACTACTGGAGCTGGATCCGCCAGCACCCAGGGA CCCGGCTCCTCATCTATGGTGCATCCAGCAGGG AGGGCCTGGAGTGGATTGGGTACATCTATTACA CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GTGGGAGCACCTACTACAACCCGTCCCTCAAGA GGTCTGGGACAGACTTCACTCTCACCATCAGCA GTCGAGTTACCATATCAGTAGACACGTCTAAGA GACAGGAGCCTGATGATTTTGCAGTGTATTACT ACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGC GTCAGCAGTATGGTAGTTCACCGCTCACTTTCGG CGCGGACACGGCCGTGTATTACTGTGCGAGAGA CGGAGGGACCAAGGTGGAGATCAAACGA TCGTATTACGATTTTTGGAGTGGTTATGGGGGGC SEQ ID NO: 1579 GGTATGGACGTCTGGGGCCAAGGGACCACGGTC ACCGTCTCCTCA SEQ ID NO: 1736 AA EIVLTQSPGTLSLSPGERATLSCRASQSISYSYLAW QVQLQESGPGLVKPSQTLSLTCTVSGDSISSGGYY YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF WSWIRQHPGKGLEWIGYIYYSGSTYYNPSLKSRVT TLTISRQEPDDFAVYYCQQYGSSPLTFGGGTKVEI ISVDTSKNQFSLKLSSVTAADTAVYYCARDRITIFG KR VVMGGGMDVWGQGTTVTVSS SEQ ID NO: 9 SEQ ID NO: 166 IPS: 336041 2G10_LC1 NA GAAATAGTGATGACGCAGTCTCCAGCCACCCTG CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCAGCATCTGGATTCACCTTCAGTAACTATGGC GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC ATGCACTGGGTCCGCCAGGCTCCAGGCGAGGGG AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC CTGGAGTGGGTGGCAGCTATATGGTTTGATGGA ACTGGTATCCCAGCCAGGGTCAGTGGCAGTGGG AGTGATAAATACTATGCAGACTCCGTGAAGGGC TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC CTGCAGTCTGAAGATTTTGCAGTTTATTACTGTC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC AGCAGTATAATAACTGGCCTCTCACTTTCGGCG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GAGGGACCAAGGTGGAGATCAAACGA CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG SEQ ID NO: 1580 GGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1737 AA EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM YQQKPGQAPRLLIYGAATRATGIPARVSGSGSGTE HWVRQAPGEGLEWVAAIWFDGSDKYYADSVKG FTLTISSLQSEDFAVYYCQQYNNWPLTFGGGTKVE RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ KR AIFGVVPDYWGQGTLVTVSS SEQ ID NO: 10 SEQ ID NO: 167 iPS: 336077 4H9.004 NA GACATTCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGGCATTAGAAATGAGTTAG GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AACGCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGGAA GTGGGGTCCCATCAAGGTTCAGCGGCAGTGGAT GTAATAAATACTATGCAGACTCCGTGAAGGGCC CTGGGACAGAGTTCACTCTCACAATCAGCAGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTTGTAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAGTTACCCATTCACTTTCGGCCCT AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGGACCAAAGTGGATGTCAAACGA GGACGATTTTTGGAGTGCTCTTGGGGGACTACT SEQ ID NO: 1581 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1738 AA DIQMTQSPSSLSASVGDRVTITCRASQGIRNELGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM YQQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDGSNKYYADSVKG FTLTISSLQPEDFVTYYCLQHNSYPFTFGPGTKVDV RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG KR TIFGVLLGDYWGQGTLVTVSS SEQ ID NO: 11 SEQ ID NO: 168 iPS: 336088 6A5.004 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTGGGGGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTACCAACTATTTAA GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC AACTCCTGATCTACGATGCTTCCAATTTGGAGCC TGGAGTGGGTGGCAGCTATATGGTATGATGGAA AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC ATAATAAATACTATGCAGACTCCGTGAAGGGCC TGGGACAGATTTTACTTTCACCATCAGCAGCCTG GATTCACCATCTCCAGAGACAGTTCCAAGAACA CAGCCTGAAGATATTGCAACATATTACTGTCAA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG CAGTATGATGATCTATTCACTTTCGGCCCTGGGA AGGACACGGCTGTGTATTACTGTGCGAGAGATC CCAAAGTGGATATCAAACGA GGACGATTTTTGGAGTGGTCCTTGAGTACCTCG SEQ ID NO: 1582 GCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1739 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD HWVRQPPGKGLEWVAAIWYDGNNKYYADSVKG FTFTISSLQPEDIATYYCQQYDDLFTFGPGTKVDIK RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR R TIFGVVLEYLGQGTLVTVSS SEQ ID NO: 12 SEQ ID NO: 169 iPS: 336099 17H11.004 NA GACATCCAGATGACCCAGTCTCCATCTTCCGTGT CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTG CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTGAAGCCTTCGGAGACCCTGTCCCTCACCTGC GTCGGGCGAGTCAGGGTCTTATCATCTGGTTAG ACTGTCTCTCAGGGCTCCATCAGTAGTTACTACT CCTGGTATCAGCAGAAACCGGGGAAAGCCCCTA GGAGCTGGATCCGGCAGCCCGCCGGGAAGGGA AACTCCTGATCTATGCTGCATCCAGTTTGCAAAG CTAGAGTGGATTGGCCGTATCTATACCAGTGGG TGGGGTCCCATCAAGGTTCAGCGGCAGTGGCTC AGCACCAACTACAACCCCTCCCTCAAGAGTCGA TGGGACAGATTTCACTCTCACCATCAGCAGCCT GTCACCATGTCAATAGACACGTCCAAGAACCAG ACAGCCTGAAGATTTTGCAACTTACTATTGTCAA TTCTCCCTGAAACTGAACTCTGTGACCGCCGCG CAGACTAACAGTTTCCCTCCGACGTTCGGCCAA GACACGGCCGTGTATTACTGTGCGAGAGATGTA GGGACCAAGGTGGAAATCAAACGA GCAGTGGCTGGCTTTGACTACTGGGGCCAGGGA SEQ ID NO: 1583 ACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1740 AA DIQMTQSPSSVSASVGDRVTITCRASQGLIIWLAW QVQLQESGPGLVKPSETLSLTCTVSQGSISSYYWS YQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTD WIRQPAGKGLEWIGRIYTSGSTNYNPSLKSRVTMS FTLTISSLQPEDFATYYCQQTNSFPPTFGQGTKVEI IDTSKNQFSLKLNSVTAADTAVYYCARDVAVAGF KR DYWGQGTLVTVSS SEQ ID NO: 13 SEQ ID NO: 170 iPS: 359621 17H11.004. NA GACATCCAGATGACCCAGTCTCCATCTTCCGTGT CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTG 001 CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTGAAGCCTTCGGAGACCCTGTCCCTCACCTGC GTCGGGCGAGTCAGGGTCTTATCATCTGGTTAG ACTGTCTCTGGGGGCTCCATCAGTAGTTACTACT CCTGGTATCAGCAGAAACCGGGGAAAGCCCCTA GGAGCTGGATCCGGCAGCCCGCCGGGAAGGGA AACTCCTGATCTATGCTGCATCCAGTTTGCAAAG CTAGAGTGGATTGGCCGTATCTATACCAGTGGG TGGGGTCCCATCAAGGTTCAGCGGCAGTGGCTC AGCACCAACTACAACCCCTCCCTCAAGAGTCGA TGGGACAGATTTCACTCTCACCATCAGCAGCCT GTCACCATGTCAATAGACACGTCCAAGAACCAG ACAGCCTGAAGATTTTGCAACTTACTATTGTCAA TTCTCCCTGAAACTGAACTCTGTGACCGCCGCG CAGACTAACAGTTTCCCTCCGACGTTCGGCCAA GACACGGCCGTGTATTACTGTGCGAGAGATGTA GGGACCAAGGTGGAAATCAAACGA GCAGTGGCTGGCTTTGACTACTGGGGCCAGGGA SEQ ID NO: 1584 ACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1741 AA DIQMTQSPSSVSASVGDRVTITCRASQGLIIWLAW QVQLQESGPGLVKPSETLSLTCTVSGGSISSYYWS YQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTD WIRQPAGKGLEWIGRIYTSGSTNYNPSLKSRVTMS FTLTISSLQPEDFATYYCQQTNSFPPTFGQGTKVEI IDTSKNQFSLKLNSVTAADTAVYYCARDVAVAGF KR DYWGQGTLVTVSS SEQ ID NO: 14 SEQ ID NO: 171 iPS: 359781 4H9.004. NA GACATTCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG 001 CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGGCATTAGAAATGAGTTAG GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AACTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCATCAAGGTTCAGCGGCAGTGGAT GTAATAAATACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAGTTCACTCTCACAATCAGCAGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTTGTAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAGTTACCCATTCACTTTCGGCCA AGGACACGGCTGTGTATTACTGTGCGCGAGATG AGGGACCAAAGTGGATGTCAAACGA GGACGATTTTTGGAGTGCTCTTGGGGGACTACT SEQ ID NO: 1585 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1742 AA DIQMTQSPSSLSASVGDRVTITCRASQGIRNELGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG FTLTIS SLQPEDFVTYYCLQHNSYPFTFGQGTKVD RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG VKR TIFGVLLGDYWGQGTLVTVSS SEQ ID NO: 15 SEQ ID NO: 172 iPS: 360929 4H9.004. NA GACATTCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG 002 CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGGCATTAGAAATGAGTTAG GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AACTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCATCAAGGTTCAGCGGCAGTGGAT GTAATAAATACTATGCAGACTCCGTGAAGGGCC CTGGGACAGAGTTCACTCTCACAATCAGCAGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTTGTAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAGTTACCCATTCACTTTCGGCCA AGGACACGGCTGTGTATTACTGTGCGCGAGATG AGGGACCAAAGTGGATGTCAAACGA GGACGATTTTTGGAGTGCTCTTGGGGGACTACT SEQ ID NO: 1586 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1743 AA DIQMTQSPSSLSASVGDRVTITCRASQGIRNELGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDASNKYYADSVKG FTLTISSLQPEDFVTYYCLQHNSYPFTFGQGTKVD RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG VKR TIFGVLLGDYWGQGTLVTVSS SEQ ID NO: 16 SEQ ID NO: 173 iPS: 360936 4H9.004. NA GACATTCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG 003 CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGGCATTAGAAATGAGTTAG GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AACTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGGAA GTGGGGTCCCATCAAGGTTCAGCGGCAGTGGAT GTAATAAATACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAGTTCACTCTCACAATCAGCAGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTTGTAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAGTTACCCATTCACTTTCGGCCA AGGACACGGCTGTGTATTACTGTGCGCGAGATG AGGGACCAAAGTGGATGTCAAACGA GGACGATTTTTGGAGTGCTCTTGGGGGACTACT SEQ ID NO: 1587 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1744 AA DIQMTQSPSSLSASVGDRVTITCRASQGIRNELGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDGSNKYYADAVKG FTLTISSLQPEDFVTYYCLQHNSYPFTFGQGTKVD RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG VKR TIFGVLLGDYWGQGTLVTVSS SEQ ID NO: 17 SEQ ID NO: 174 iPS: 360943 4H9.004. NA GACATTCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG 004 CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGGCATTAGAAATGAGTTAG GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AACTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCATCAAGGTTCAGCGGCAGTGGAT GTAATAAATACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAGTTCACTCTCACAATCAGCAGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTTGTAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAGTTACCCATTCACTTTCGGCCCT AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGGACCAAAGTGGATGTCAAACGA GGACGATTTTTGGAGTGCTCTTGGGGGACTACT SEQ ID NO: 1588 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1745 AA DIQMTQSPSSLSASVGDRVTITCRASQGIRNELGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG FTLTISSLQPEDFVTYYCLQHNSYPFTFGPGTKVDV RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG KR TIFGVLLGDYWGQGTLVTVSS SEQ ID NO: 18 SEQ ID NO: 175 iPS: 360949 4H9.004. NA GACATTCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG 005 CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGGCATTAGAAATGAGTTAG GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AACGCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCATCAAGGTTCAGCGGCAGTGGAT GTAATAAATACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAGTTCACTCTCACAATCAGCAGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTTGTAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAGTTACCCATTCACTTTCGGCCA AGGACACGGCTGTGTATTACTGTGCGCGAGATG AGGGACCAAAGTGGATGTCAAACGA GGACGATTTTTGGAGTGCTCTTGGGGGACTACT SEQ ID NO: 1589 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1746 AA DIQMTQSPSSLSASVGDRVTITCRASQGIRNELGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM YQQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG FTLTISSLQPEDFVTYYCLQHNSYPFTFGQGTKVD RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG VKR TIFGVLLGDYWGQGTLVTVSS SEQ ID NO: 19 SEQ ID NO: 176 iPS: 359761 4H9.004. NA GACATTCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG 006 CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGGCATTAGAAATGAGTTAG GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AACTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCATCAAGGTTCAGCGGCAGTGGAT GTAATAAATACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAGTTCACTCTCACAATCAGCAGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTTGTAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAGTTACCCATTCACTTTCGGCCA AGGACACGGCTGTGTATTACTGTGCGCGAGATA AGGGACCAAAGTGGATGTCAAACGA GGACGATTTTTGGAGTGCTCTTGGGGGACTACT SEQ ID NO: 1590 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1747 AA DIQMTQSPSSLSASVGDRVTITCRASQGIRNELGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG FTLTISSLQPEDFVTYYCLQHNSYPFTFGQGTKVD RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR VKR TIFGVLLGDYWGQGTLVTVSS SEQ ID NO: 20 SEQ ID NO: 177 iPS: 360955 4B1.010 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAATA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGTCG ACAGCATAATAATTACCCCTTCACTTTCGGCCAA CGGACACGGCTGTGTATTATTGTGCGCGAGATG GGGACCAAAGTGGATATCAAACGA GGACGATCTTTGGAGTGGTCTTGGGGGACTACT SEQ ID NO: 1591 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1748 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT HWVRQAPGKGLEWVAVIWYDASNENYADAVKG LTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDIK RFTISRDNSKNTLYLQMNSLRVADTAVYYCARDG R TIFGVVLGDYWGQGTLVTVSS SEQ ID NO: 21 SEQ ID NO: 178 iPS: 360962 4B1.011 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAATA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGTCG ACAGCATAATAATTACCCCTTCACTTTCGGCCAA CGGACACGGCTGTGTATTATTGTGCGCGAGATG GGGACCAAAGTGGATATCAAACGA GGACGATCTTTGGAGTGGTCTTGGGGGACTACT SEQ ID NO: 1592 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1749 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM QQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTEFT HWVRQAPGKGLEWVAVIWYDASNENYADAVKG LTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDIK RFTISRDNSKNTLYLQMNSLRVADTAVYYCARDG R TIFGVVLGDYWGQGTLVTVSS SEQ ID NO: 22 SEQ ID NO: 179 iPS: 360968 4B1.012 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAATA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGTCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT CGGACACGGCTGTGTATTATTGTGCGCGAGATG GGGACCAAAGTGGATATCAAACGA GGACGATCTTTGGAGTGGTCTTGGGGGACTACT SEQ ID NO: 1593 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1750 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT HWVRQAPGKGLEWVAVIWYDASNENYADAVKG LTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDIKR RFTISRDNSKNTLYLQMNSLRVADTAVYYCARDG SEQ ID NO: 23 TIFGVVLGDYWGQGTLVTVSS SEQ ID NO: 180 iPS: 360974 4B1.013 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACTCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAATA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCACATGAACAGCCTGAGAGTCG ACAGCATAATAATTACCCCTTCACTTTCGGCCAA CGGACACGGCTGTGTATTATTGTGCGCGAGATG GGGACCAAAGTGGATATCAAACGA GGACGATCTTTGGAGTGGTCTTGGGGGACTACT SEQ ID NO: 1594 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1751 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT HWVRQAPGKGLEWVAVIWYDASNENYADSVKG LTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDIK RFTISRDNSKNTLYLHMNSLRVADTAVYYCARDG R TIFGVVLGDYWGQGTLVTVSS SEQ ID NO: 24 SEQ ID NO: 181 iPS: 360978 4B1.014 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGGAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAATA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCACATGAACAGCCTGAGAGTCG ACAGCATAATAATTACCCCTTCACTTTCGGCCAA CGGACACGGCTGTGTATTATTGTGCGCGAGATG GGGACCAAAGTGGATATCAAACGA GGACGATCTTTGGAGTGGTCTTGGGGGACTACT SEQ ID NO: 1595 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1752 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT HWVRQAPGKGLEWVAVIWYDGSNENYADAVKG LTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDIK RFTISRDNSKNTLYLHMNSLRVADTAVYYCARDG R TIFGVVLGDYWGQGTLVTVSS SEQ ID NO: 25 SEQ ID NO: 182 iPS: 359785 4B1.015 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAATA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGTCG ACAGCATAATAATTACCCCTTCACTTTCGGCCAA AGGACACGGCTGTGTATTATTGTGCGCGAGATA GGGACCAAAGTGGATATCAAACGA GGACGATCTTTGGAGTGGTCTTGGGGGACTACT SEQ ID NO: 1596 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1753 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT HWVRQAPGKGLEWVAVIWYDASNENYADAVKG LTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDIK RFTISRDNSKNTLYLQMNSLRVEDTAVYYCARDR R TIFGVVLGDYWGQGTLVTVSS SEQ ID NO: 26 SEQ ID NO: 183 iPS: 360982 4B1.016 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAATA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGTCG ACAGCATAATAATTACCCCTTCACTTTCGGCCAA AGGACACGGCTGTGTATTATTGTGCGCGAGATG GGGACCAAAGTGGATATCAAACGA GGACGATCTTTGGAGTGGTCTTGGGGGACTACT SEQ ID NO: 1597 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1754 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT HWVRQAPGKGLEWVAVIWYDASNENYADAVKG LTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDIK RFTISRDNSKNTLYLQMNSLRVEDTAVYYCARDG R TIFGVVLGDYWGQGTLVTVSS SEQ ID NO: 27 SEQ ID NO: 184 iPS: 335922 18F2 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCACCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGGAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACTCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCACATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGGACCAAAGTGGATATCAAACGA GGACGATCTTTGGAGTGGTCTTGGGGGACTACT SEQ ID NO: 1598 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1755 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM YHQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDGSNENYADSVKG FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI RFTISRDNSKNTLYLHMNSLRAADTAVYYCARDG KR TIFGVVLGDYWGQGTLVTVSS SEQ ID NO: 28 SEQ ID NO: 185 iPS: 360986 18F2.002 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGGACCAAAGTGGATATCAAACGA GGACGATCTTTGGAGTGGTCTTGGGGGACTACT SEQ ID NO: 1599 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1756 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDASNENYADAVKG FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI RFTISRDNSKNTLYLQMNSLRAADTAVYYCARDG KR TIFGVVLGDYWGQGTLVTVSS SEQ ID NO: 29 SEQ ID NO: 186 iPS: 360995 18F2.003 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCACATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGGACCAAAGTGGATATCAAACGA GGACGATCTTTGGAGTGGTCTTGGGGGACTACT SEQ ID NO: 1600 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1757 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDASNENYADAVKG FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI RFTISRDNSKNTLYLHMNSLRAADTAVYYCARDG KR TIFGVVLGDYWGQGTLVTVSS SEQ ID NO: 30 SEQ ID NO: 187 iPS: 360999 18F2.004 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCACCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGGACCAAAGTGGATATCAAACGA GGACGATCTTTGGAGTGGTCTTGGGGGACTACT SEQ ID NO: 1601 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1758 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM YHQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDASNENYADAVKG FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI RFTISRDNSKNTLYLQMNSLRAADTAVYYCARDG KR TIFGVVLGDYWGQGTLVTVSS SEQ ID NO: 31 SEQ ID NO: 188 iPS: 361005 18F2.005 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGGACCAAAGTGGATATCAAACGA GGACGATCTTTGGAGTGGTCTTGGGGGACTACT SEQ ID NO: 1602 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1759 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM YQQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDASNENYADAVKG FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI RFTISRDNSKNTLYLQMNSLRAADTAVYYCARDG KR TIFGVVLGDYWGQGTLVTVSS SEQ ID NO: 32 SEQ ID NO: 189 iPS: 361009 18F2.006 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCACATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGGACCAAAGTGGATATCAAACGA GGACGATCTTTGGAGTGGTCTTGGGGGACTACT SEQ ID NO: 1603 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1760 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM YQQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDASNENYADAVKG FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI RFTISRDNSKNTLYLHMNSLRAADTAVYYCARDG KR TIFGVVLGDYWGQGTLVTVSS SEQ ID NO: 33 SEQ ID NO: 190 iPS: 361013 18F2.007 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCACCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCACATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGGACCAAAGTGGATATCAAACGA GGACGATCTTTGGAGTGGTCTTGGGGGACTACT SEQ ID NO: 1604 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1761 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM YHQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDASNENYADAVKG FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI RFTISRDNSKNTLYLHMNSLRAADTAVYYCARDG KR TIFGVVLGDYWGQGTLVTVSS SEQ ID NO: 34 SEQ ID NO: 191 iPS: 361017 18F2.003 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCACCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGGACCAAAGTGGATATCAAACGA GGACGATCTTTGGAGTGGTCTTGGGGGACTACT SEQ ID NO: 1605 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1762 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM YHQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDASNENYADAVKG FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI RFTISRDNSKNTLYLQMNSLRAADTAVYYCARDG KR TIFGVVLGDYWGQGTLVTVSS SEQ ID NO: 35 SEQ ID NO: 192 iPS: 361021 18F2.009 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGGAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGGACCAAAGTGGATATCAAACGA GGACGATCTTTGGAGTGGTCTTGGGGGACTACT SEQ ID NO: 1606 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1763 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDGSNENYADAVKG FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI RFTISRDNSKNTLYLQMNSLRAADTAVYYCARDG KR TIFGVVLGDYWGQGTLVTVSS SEQ ID NO: 36 SEQ ID NO: 193 iPS: 361028 18F2.010 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACTCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGGACCAAAGTGGATATCAAACGA GGACGATCTTTGGAGTGGTCTTGGGGGACTACT SEQ ID NO: 1607 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1764 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDASNENYADSVKG FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI RFTISRDNSKNTLYLQMNSLRAADTAVYYCARDG KR TIFGVVLGDYWGQGTLVTVSS SEQ ID NO: 37 SEQ ID NO: 194 iPS: 360535 18F2.011 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCAA AGGACACGGCTGTGTATTACTGTGCGAGAGATA GGGACCAAAGTGGATATCAAACGA GGACGATCTTTGGAGTGGTCTTGGGGGACTACT SEQ ID NO: 1608 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1765 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDASNENYADAVKG FTLTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDI RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR KR TIFGVVLGDYWGQGTLVTVSS SEQ ID NO: 38 SEQ ID NO: 195 iPS: 361035 18F2.012 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT AGGACACGGCTGTGTATTACTGTGCGAGAGATG GGGACCAAAGTGGATATCAAACGA GGACGATCTTTGGAGTGGTCTTGGGGGACTACT SEQ ID NO: 1609 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1766 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDASNENYADAVKG FTLTISSLQPEDFATYYSLQHNNYPFTFGPGTKVDI RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG KR TIFGVVLGDYWGQGTLVTVSS SEQ ID NO: 39 SEQ ID NO: 196 iPS: 359940 2F11.002 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTACGATGCATCCAATTTGGAAA CTGGAGTGGGTGGCAGTTATATGGTATGATGCA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT AGTAATAAATACTATGCAGACGCCGTGAAGGGC CTGGGACAGATTTTAGTCTCACCATCAGCAGCC CGATTCACCATCTCCAGGGACAATTCCAAGAAC TGCAGCCTGAAGATTTTGCAACATATTACTGTCA ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC ACAGTATGATATTCTCCTCACTTTCGGCGGAGG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GACCAAGGTGGAGATCAAGCGA AGGACGATTTTTGGAGTGGTTCTTGACTACTGG SEQ ID NO: 1610 GGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1767 AA DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG FSLTISSLQPEDFATYYCQQYDILLTFGGGTKVEIK RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR R TIFGVVLDYWGQGTLVTVSS SEQ ID NO: 40 SEQ ID NO: 197 iPS: 361039 2F11.003 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTACGATGCATCCAATTTGGAAA CTGGAGTGGGTGGCAGTTATATGGTATGATGCA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT AGTAATAAATACTATGCAGACGCCGTGAAGGGC CTGGGACAGATTTTAGTCTCACCATCAGCAGCC CGATTCACCATCTCCAGCGACAATTCCAAGAAC TGCAGCCTGAAGATTTTGCAACATATTACTGTCA ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC ACAGTATGATATTCTCCTCACTTTCGGCGGAGG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GACCAAGGTGGAGATCAAGCGA AGGACGATTTTTGGAGTGGTTCTTGACTACTGG SEQ ID NO: 1611 GGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1768 AA DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG FSLTISSLQPEDFATYYCQQYDILLTFGGGTKVEIK RFTISSDNSKNTLYLQMNSLRAEDTAVYYCARDR R TIFGVVLDYWGQGTLVTVSS SEQ ID NO: 41 SEQ ID NO: 198 iPS: 361043 2F11.004 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTACGATGCATCCAATTTGGAAA CTGGAGTGGGTGGCAGTTATATGGTATGATGCA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT AGTAATAAATACTATGCAGACGCCGTGAAGGGC CTGGGACAGATTTTAGTCTCACCATCAGCAGCC CGATTCACCATCTCCAGGGACAATTCCAAGAAC TGCAGCCTGAAGATATTGCAACATATTACTGTC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC AACAGTATGATATTCTCCTCACTTTCGGCGGAG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GGACCAAGGTGGAGATCAAGCGA AGGACGATTTTTGGAGTGGTTCTTGACTACTGG SEQ ID NO: 1612 GGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1769 AA DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG FSLTISSLQPEDIATYYCQQYDILLTFGGGTKVEIK RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR R TIFGVVLDYWGQGTLVTVSS SEQ ID NO: 42 SEQ ID NO: 199 iPS: 361049 2F11.005 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTACGATGCATCCAATTTGGAAA CTGGAGTGGGTGGCAGTTATATGGTATGATGCA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT AGTAATAAATACTATGCAGACGCCGTGAAGGGC CTGGGACAGATTTTAGTTTCACCATCAGCAGCCT CGATTCACCATCTCCAGGGACAATTCCAAGAAC GCAGCCTGAAGATTTTGCAACATATTACTGTCA ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC ACAGTATGATATTCTCCTCACTTTCGGCGGAGG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GACCAAGGTGGAGATCAAGCGA AGGACGATTTTTGGAGTGGTTCTTGACTACTGG SEQ ID NO: 1613 GGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1770 AA DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG FSFTISSLQPEDFATYYCQQYDILLTFGGGTKVEIK RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR R TIFGVVLDYWGQGTLVTVSS SEQ ID NO: 43 SEQ ID NO: 200 iPS: 361055 2F11.006 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTACGATGCATCCAATTTGGAAA CTGGAGTGGGTGGCAGTTATATGGTATGATGCA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT AGTAATAAATACTATGCAGACGCCGTGAAGGGC CTGGGACAGATTTTAGTCTCACCATCAGCAGCC CGATTCACCATCTCCAGCGACAATTCCAAGAAC TGCAGCCTGAAGATATTGCAACATATTACTGTC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC AACAGTATGATATTCTCCTCACTTTCGGCGGAG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GGACCAAGGTGGAGATCAAGCGA AGGACGATTTTTGGAGTGGTTCTTGACTACTGG SEQ ID NO: 1614 GGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1771 AA DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG FSLTISSLQPEDIATYYCQQYDILLTFGGGTKVEIK RFTISSDNSKNTLYLQMNSLRAEDTAVYYCARDR R TIFGVVLDYWGQGTLVTVSS SEQ ID NO: 44 SEQ ID NO: 201 iPS: 361059 2F11.007 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTACGATGCATCCAATTTGGAAA CTGGAGTGGGTGGCAGTTATATGGTATGATGCA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT AGTAATAAATACTATGCAGACGCCGTGAAGGGC CTGGGACAGATTTTAGTTTCACCATCAGCAGCCT CGATTCACCATCTCCAGCGACAATTCCAAGAAC GCAGCCTGAAGATTTTGCAACATATTACTGTCA ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC ACAGTATGATATTCTCCTCACTTTCGGCGGAGG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GACCAAGGTGGAGATCAAGCGA AGGACGATTTTTGGAGTGGTTCTTGACTACTGG SEQ ID NO: 1615 GGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1772 AA DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG FSFTISSLQPEDFATYYCQQYDILLTFGGGTKVEIK RFTISSDNSKNTLYLQMNSLRAEDTAVYYCARDR R TIFGVVLDYWGQGTLVTVSS SEQ ID NO: 45 SEQ ID NO: 202 iPS: 361063 2F11.008 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTACGATGCATCCAATTTGGAAA CTGGAGTGGGTGGCAGTTATATGGTATGATGCA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT AGTAATAAATACTATGCAGACGCCGTGAAGGGC CTGGGACAGATTTTAGTTTCACCATCAGCAGCCT CGATTCACCATCTCCAGGGACAATTCCAAGAAC GCAGCCTGAAGATATTGCAACATATTACTGTCA ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC ACAGTATGATATTCTCCTCACTTTCGGCGGAGG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GACCAAGGTGGAGATCAAGCGA AGGACGATTTTTGGAGTGGTTCTTGACTACTGG SEQ ID NO: 1616 GGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1773 AA DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG FSFTISSLQPEDIATYYCQQYDILLTFGGGTKVEIK RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR R TIFGVVLDYWGQGTLVTVSS SEQ ID NO: 46 SEQ ID NO: 203 iPS: 359949 2F11.009 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTACGATGCATCCAATTTGGAAA CTGGAGTGGGTGGCAGTTATATGGTATGATGCA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT AGTAATAAATACTATGCAGACTCCGTGAAGGGC CTGGGACAGATTTTAGTCTCACCATCAGCAGCC CGATTCACCATCTCCAGGGACAATTCCAAGAAC TGCAGCCTGAAGATTTTGCAACATATTACTGTCA ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC ACAGTATGATATTCTCCTCACTTTCGGCGGAGG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GACCAAGGTGGAGATCAAGCGA AGGACGATTTTTGGAGTGGTTCTTGACTACTGG SEQ ID NO: 1617 GGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1774 AA DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD HWVRQAPGKGLEWVAVIWYDASNKYYADSVKG FSLTISSLQPEDFATYYCQQYDILLTFGGGTKVEIK RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR R TIFGVVLDYWGQGTLVTVSS SEQ ID NO: 47 SEQ ID NO: 204 iPS: 359956 2F11.010 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTACGATGCATCCAATTTGGAAA CTGGAGTGGGTGGCAGTTATATGGTATGATGGA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT AGTAATAAATACTATGCAGACGCCGTGAAGGGC CTGGGACAGATTTTAGTCTCACCATCAGCAGCC CGATTCACCATCTCCAGGGACAATTCCAAGAAC TGCAGCCTGAAGATTTTGCAACATATTACTGTCA ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC ACAGTATGATATTCTCCTCACTTTCGGCGGAGG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GACCAAGGTGGAGATCAAGCGA AGGACGATTTTTGGAGTGGTTCTTGACTACTGG SEQ ID NO: 1618 GGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1775 AA DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD HWVRQAPGKGLEWVAVIWYDGSNKYYADAVKG FSLTISSLQPEDFATYYCQQYDILLTFGGGTKVEIK RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR R TIFGVVLDYWGQGTLVTVSS SEQ ID NO: 48 SEQ ID NO: 205 iPS: 359865 6H1.002 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATAAATACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGGACCAAAGTGGATATCAAACGA GGACGATTTTTGGAGTGCTCTTGGGGGACTACT SEQ ID NO: 1619 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1776 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM QQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTEFT HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG LTISSLQPEDFATYYSLQHNNYPFTFGPGTKVDIKR RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG SEQ ID NO: 49 TIFGVLLGDYWGQGTLVTVSS SEQ ID NO: 206 iPS: 359869 6H1.003 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATAAATACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT AGGACACGGCTGTGTATTACTGTGCGCGAGATA GGGACCAAAGTGGATATCAAACGA GGACGATTTTTGGAGTGCTCTTGGGGGACTACT SEQ ID NO: 1620 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1777 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM QQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTEFT HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG LTISSLQPEDFATYYSLQHNNYPFTFGPGTKVDIKR RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR SEQ ID NO: 50 TIFGVLLGDYWGQGTLVTVSS SEQ ID NO: 207 iPS: 359873 6H1.004 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATAAATACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCAA AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGGACCAAAGTGGATATCAAACGA GGACGATTTTTGGAGTGCTCTTGGGGGACTACT SEQ ID NO: 1621 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1778 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG LTISSLQPEDFATYYSLQHNNYPFTFGQGTKVDIK RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG R TIFGVLLGDYWGQGTLVTVSS SEQ ID NO: 51 SEQ ID NO: 208 iPS: 359877 6H1.005 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATAAATACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCAA AGGACACGGCTGTGTATTACTGTGCGCGAGATA GGGACCAAAGTGGATATCAAACGA GGACGATTTTTGGAGTGCTCTTGGGGGACTACT SEQ ID NO: 1622 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1779 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG LTISSLQPEDFATYYSLQHNNYPFTFGQGTKVDIK RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR R TIFGVLLGDYWGQGTLVTVSS SEQ ID NO: 52 SEQ ID NO: 209 iPS: 361067 6H1.006 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGGAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATAAATACTATGCAGACTCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGGACCAAAGTGGATATCAAACGA GGACGATTTTTGGAGTGCTCTTGGGGGACTACT SEQ ID NO: 1623 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1780 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT HWVRQAPGKGLEWVAVIWYDGSNKYYADSVKG LTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDIKR RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG SEQ ID NO: 53 TIFGVLLGDYWGQGTLVTVSS SEQ ID NO: 210 iPS: 361071 6H1.007 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATAAATACTATGCAGACTCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGGACCAAAGTGGATATCAAACGA GGACGATTTTTGGAGTGCTCTTGGGGGACTACT SEQ ID NO: 1624 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1781 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT HWVRQAPGKGLEWVAVIWYDASNKYYADSVKG LTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDIKR RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG SEQ ID NO: 54 TIFGVLLGDYWGQGTLVTVSS SEQ ID NO: 211 iPS: 361075 6H1.008 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGGAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATAAATACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGGACCAAAGTGGATATCAAACGA GGACGATTTTTGGAGTGCTCTTGGGGGACTACT SEQ ID NO: 1625 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1782 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT HWVRQAPGKGLEWVAVIWYDGSNKYYADAVKG LTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDIKR RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG SEQ ID NO: 55 TIFGVLLGDYWGQGTLVTVSS SEQ ID NO: 212 iPS: 361079 6A5.004. NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG 001 CTGCATCTGTGGGGGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTACCAACTATTTAA GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC AACTCCTGATCTACGATGCTTCCAATTTGGAGCC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC ATAATAAATACTATGCAGACGCCGTGAAGGGCC TGGGACAGATTTTACTCTCACCATCAGCAGCCT GATTCACCATCTCCAGAGACAGTTCCAAGAACA GCAGCCTGAAGATTTTGCAACATATTACTGTCA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGTATGATGATCTATTCACTTTCGGCCCTGGG AGGACACGGCTGTGTATTACTGTGCGAGAGATC ACCAAAGTGGATATCAAACGA GGACGATTTTTGGAGTGGTCCTTGAGTACTGGG SEQ ID NO: 1626 GCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1783 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG FTLTISSLQPEDFATYYCQQYDDLFTFGPGTKVDIK RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR R TIFGVVLEYWGQGTLVTVSS SEQ ID NO: 56 SEQ ID NO: 213 iPS: 361085 6A5.004. NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG 002 CTGCATCTGTGGGGGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTACCAACTATTTAA GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC AACTCCTGATCTACGATGCTTCCAATTTGGAGCC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC ATAATAAATACTATGCAGACGCCGTGAAGGGCC TGGGACAGATTTTACTCTCACCATCAGCAGCCT GATTCACCATCTCCAGAGACAGTTCCAAGAACA GCAGCCTGAAGATATTGCAACATATTACTGTCA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGTATGATGATCTATTCACTTTCGGCCCTGGG AGGACACGGCTGTGTATTACTGTGCGAGAGATC ACCAAAGTGGATATCAAACGA GGACGATTTTTGGAGTGGTCCTTGAGTACTGGG SEQ ID NO: 1627 GCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1784 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG FTLTISSLQPEDIATYYCQQYDDLFTFGPGTKVDIK RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR R TIFGVVLEYWGQGTLVTVSS SEQ ID NO: 57 SEQ ID NO: 214 iPS: 361091 6A5.004. NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG 003 CTGCATCTGTGGGGGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTACCAACTATTTAA GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC AACTCCTGATCTACGATGCTTCCAATTTGGAGCC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC ATAATAAATACTATGCAGACGCCGTGAAGGGCC TGGGACAGATTTTACTCTCACCATCAGCAGCCT GATTCACCATCTCCAGAGACAGTTCCAAGAACA GCAGCCTGAAGATTTTGCAACATATTACTGTCA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGTATGATGATCTATTCACTTTCGGCCCTGGG AGGACACGGCTGTGTATTACTGTGCGAGAGATC ACCAAAGTGGATATCAAACGA GGACGATTTTTGGAGTGGTCCTTGAGTACCTCG SEQ ID NO: 1628 GCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1785 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG FTLTISSLQPEDFATYYCQQYDDLFTFGPGTKVDIK RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR R TIFGVVLEYLGQGTLVTVSS SEQ ID NO: 58 SEQ ID NO: 215 iPS: 361095 6A5.004. NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG 004 CTGCATCTGTGGGGGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTACCAACTATTTAA GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC AACTCCTGATCTACGATGCTTCCAATTTGGAGCC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC ATAATAAATACTATGCAGACGCCGTGAAGGGCC TGGGACAGATTTTACTTTCACCATCAGCAGCCTG GATTCACCATCTCCAGAGACAGTTCCAAGAACA CAGCCTGAAGATTTTGCAACATATTACTGTCAA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG CAGTATGATGATCTATTCACTTTCGGCCCTGGGA AGGACACGGCTGTGTATTACTGTGCGAGAGATC CCAAAGTGGATATCAAACGA GGACGATTTTTGGAGTGGTCCTTGAGTACTGGG SEQ ID NO: 1629 GCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1786 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG FTFTISSLQPEDFATYYCQQYDDLFTFGPGTKVDIK RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR R TIFGVVLEYWGQGTLVTVSS SEQ ID NO: 59 SEQ ID NO: 216 iPS: 361101 6A5.004. NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG 005 CTGCATCTGTGGGGGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTACCAACTATTTAA GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC AACTCCTGATCTACGATGCTTCCAATTTGGAGCC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC ATAATAAATACTATGCAGACGCCGTGAAGGGCC TGGGACAGATTTTACTCTCACCATCAGCAGCCT GATTCACCATCTCCAGAGACAGTTCCAAGAACA GCAGCCTGAAGATATTGCAACATATTACTGTCA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGTATGATGATCTATTCACTTTCGGCCCTGGG AGGACACGGCTGTGTATTACTGTGCGAGAGATC ACCAAAGTGGATATCAAACGA GGACGATTTTTGGAGTGGTCCTTGAGTACCTCG SEQ ID NO: 1630 GCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1787 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG FTLTISSLQPEDIATYYCQQYDDLFTFGPGTKVDIK RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR R TIFGVVLEYLGQGTLVTVSS SEQ ID NO: 60 SEQ ID NO: 217 iPS: 361105 6A5.004. NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG 006 CTGCATCTGTGGGGGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTACCAACTATTTAA GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC AACTCCTGATCTACGATGCTTCCAATTTGGAGCC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC ATAATAAATACTATGCAGACGCCGTGAAGGGCC TGGGACAGATTTTACTTTCACCATCAGCAGCCTG GATTCACCATCTCCAGAGACAGTTCCAAGAACA CAGCCTGAAGATTTTGCAACATATTACTGTCAA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG CAGTATGATGATCTATTCACTTTCGGCCCTGGGA AGGACACGGCTGTGTATTACTGTGCGAGAGATC CCAAAGTGGATATCAAACGA GGACGATTTTTGGAGTGGTCCTTGAGTACCTCG SEQ ID NO: 1631 GCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1788 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG FTFTISSLQPEDFATYYCQQYDDLFTFGPGTKVDIK RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR R TIFGVVLEYLGQGTLVTVSS SEQ ID NO: 61 SEQ ID NO: 218 iPS: 361109 6A5.004. NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG 007 CTGCATCTGTGGGGGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTACCAACTATTTAA GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC AACTCCTGATCTACGATGCTTCCAATTTGGAGCC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC ATAATAAATACTATGCAGACGCCGTGAAGGGCC TGGGACAGATTTTACTTTCACCATCAGCAGCCTG GATTCACCATCTCCAGAGACAGTTCCAAGAACA CAGCCTGAAGATATTGCAACATATTACTGTCAA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG CAGTATGATGATCTATTCACTTTCGGCCCTGGGA AGGACACGGCTGTGTATTACTGTGCGAGAGATC CCAAAGTGGATATCAAACGA GGACGATTTTTGGAGTGGTCCTTGAGTACTGGG SEQ ID NO: 1632 GCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1789 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG FTFTISSLQPEDIATYYCQQYDDLFTFGPGTKVDIK RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR R TIFGVVLEYWGQGTLVTVSS SEQ ID NO: 62 SEQ ID NO: 219 iPS: 361113 6A5.004. NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG 008 CTGCATCTGTGGGGGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTACCAACTATTTAA GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC AACTCCTGATCTACGATGCTTCCAATTTGGAGCC TGGAGTGGGTGGCAGCTATATGGTATGATGGAA AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC ATAATAAATACTATGCAGACGCCGTGAAGGGCC TGGGACAGATTTTACTCTCACCATCAGCAGCCT GATTCACCATCTCCAGAGACAGTTCCAAGAACA GCAGCCTGAAGATTTTGCAACATATTACTGTCA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGTATGATGATCTATTCACTTTCGGCCCTGGG AGGACACGGCTGTGTATTACTGTGCGAGAGATC ACCAAAGTGGATATCAAACGA GGACGATTTTTGGAGTGGTCCTTGAGTACTGGG SEQ ID NO: 1633 GCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1790 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD HWVRQPPGKGLEWVAAIWYDGNNKYYADAVKG FTLTISSLQPEDFATYYCQQYDDLFTFGPGTKVDIK RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR R TIFGVVLEYWGQGTLVTVSS SEQ ID NO: 63 SEQ ID NO: 220 iPS: 361120 6A5.004. NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG 009 CTGCATCTGTGGGGGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTACCAACTATTTAA GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC AACTCCTGATCTACGATGCTTCCAATTTGGAGCC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC ATAATAAATACTATGCAGACTCCGTGAAGGGCC TGGGACAGATTTTACTCTCACCATCAGCAGCCT GATTCACCATCTCCAGAGACAGTTCCAAGAACA GCAGCCTGAAGATTTTGCAACATATTACTGTCA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGTATGATGATCTATTCACTTTCGGCCCTGGG AGGACACGGCTGTGTATTACTGTGCGAGAGATC ACCAAAGTGGATATCAAACGA GGACGATTTTTGGAGTGGTCCTTGAGTACTGGG SEQ ID NO: 1634 GCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1791 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD HWVRQPPGKGLEWVAAIWYDANNKYYADSVKG FTLTISSLQPEDFATYYCQQYDDLFTFGPGTKVDIK RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR R TIFGVVLEYWGQGTLVTVSS SEQ ID NO: 64 SEQ ID NO: 221 iPS: 359896 6A5.004. NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG 010 CTGCATCTGTGGGGGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTACCAACTATTTAA GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC AACTCCTGATCTACGATGCTTCCAATTTGGAGCC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC ATAATAAATACTATGCAGACGCCGTGAAGGGCC TGGGACAGATTTTACTCTCACCATCAGCAGCCT GATTCACCATCTCCAGAGACAGTTCCAAGAACA GCAGCCTGAAGATTTTGCAACATATTACTGTCA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGTATGATGATCTATTCACTTTCGGCCAAGG AGGACACGGCTGTGTATTACTGTGCGAGAGATC GACCAAAGTGGATATCAAACGA GGACGATTTTTGGAGTGGTCCTTGAGTACTGGG SEQ ID NO: 1635 GCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1792 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG FTLTISSLQPEDFATYYCQQYDDLFTFGQGTKVDI RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR KR TIFGVVLEYWGQGTLVTVSS SEQ ID NO: 65 SEQ ID NO: 222 iPS: 359890 6A5.004. NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG 011 CTGCATCTGTGGGGGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTACCAACTATTTAA GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC AACTCCTGATCTACGATGCTTCCAATTTGGAGCC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC ATAATAAATACTATGCAGACGCCGTGAAGGGCC TGGGACAGATTTTACTCTCACCATCAGCAGCCT GATTCACCATCTCCAGAGACAGTTCCAAGAACA GCAGCCTGAAGATTTTGCAACATATTACTGTCA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGTATGATGATCTATTCACTTTCGGCCAAGG AGGACACGGCTGTGTATTACTGTGCGAGAGATC GACCAAAGTGGATATCAAACGA GGACGATTTTTGGAGTGGTCCTTGAGTACCTCG SEQ ID NO: 1636 GCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1793 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG FTLTISSLQPEDFATYYCQQYDDLFTFGQGTKVDI RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR KR TIFGVVLEYLGQGTLVTVSS SEQ ID NO: 66 SEQ ID NO: 223 iPS: 359567 2A11.002 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGGGCCAGTCAGATTTTTACCAGCACCTACT GCAGCGTCTGGATTCAGTTTCAGTAGCTATGGC TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGA CCAGGCTCCTCATCTATGGTGCATCCAGCAGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG AGTAATAAATACTATGAAGACGCCGTGAAGGGC GGTCTGGGACAGACTTCACTCTCACCATCAGCA CGATTCACCATCTCCAGAGACAATTCCAAGAAC GATTGGAGCCTGAAGATTTTGCAGTGTATTACT ACGCTGTTTCTGCAAGTGAACAGCCTGAGAGCC GTCAGCAGTATGGTAGCTCACCTCGCTTCGGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGGG AAGGGACACGACTGGAGATTAAACGA ATTACGATTTTTGGTCATGGGTTTGAATATTGGG SEQ ID NO: 1637 GCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1794 AA EIVLTQSPGTLSLSPGERATLSCRASQIFTSTYLAW QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF HWVRQAPGKGLEWVAVIWYDASNKYYEDAVKG TLTISRLEPEDFAVYYCQQYGSSPRFGQGTRLEIKR RFTISRDNSKNTLFLQVNSLRAEDTAVYYCARGITI SEQ ID NO: 67 FGHGFEYWGQGTLVTVSS SEQ ID NO: 224 iPS: 335965 21AA.003 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGGGCCAGTCAGATTTTTACCAGCACCTACT GCAGCGTCTGGATTCAGTTTCAGTAGCTATGGC TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGA CCAGGCTCCTCATCTATGGTGCATCCAGCAGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGGA CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG AGTAATAAATACTATGAAGACTCCGTGAAGGGC GGTCTGGGACAGACTTCACTCTCACCATCAGCA CGATTCACCATCTCCAGAGACAATTCCAAGAAC GATTGGAGCCTGAAGATTTTGCAGTGTATTACT ACGCTGTTTCTGCAAGTGAACAGCCTGAGAGCC GTCAGCAGTATGGTAGCTCACCTCGCTTCGGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGGG AAGGGACACGACTGGAGATTAAACGA ATTACGATTTTTGGTCATGGGTTTGAATATTGGG SEQ ID NO: 1638 GCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1795 AA EIVLTQSPGTLSLSPGERATLSCRASQIFTSTYLAW QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF HWVRQAPGKGLEWVAVIWYDGSNKYYEDSVKG TLTISRLEPEDFAVYYCQQYGSSPRFGQGTRLEIKR RFTISRDNSKNTLFLQVNSLRAEDTAVYYCARGITI SEQ ID NO: 68 FGHGFEYWGQGTLVTVSS SEQ ID NO: 225 iPS: 361158 2A11.004 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGGGCCAGTCAGATTTTTACCAGCACCTACT GCAGCGTCTGGATTCAGTTTCAGTAGCTATGGC TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGA CCAGGCTCCTCATCTATGGTGCATCCAGCAGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGGA CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG AGTAATAAATACTATGAAGACGCCGTGAAGGGC GGTCTGGGACAGACTTCACTCTCACCATCAGCA CGATTCACCATCTCCAGAGACAATTCCAAGAAC GATTGGAGCCTGAAGATTTTGCAGTGTATTACT ACGCTGTTTCTGCAAGTGAACAGCCTGAGAGCC GTCAGCAGTATGGTAGCTCACCTCGCTTCGGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGGG AAGGGACACGACTGGAGATTAAACGA ATTACGATTTTTGGTCATGGGTTTGAATATTGGG SEQ ID NO: 1639 GCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1796 AA EIVLTQSPGTLSLSPGERATLSCRASQIFTSTYLAW QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF HWVRQAPGKGLEWVAVIWYDGSNKYYEDAVKG TLTISRLEPEDFAVYYCQQYGSSPRFGQGTRLEIKR RFTISRDNSKNTLFLQVNSLRAEDTAVYYCARGITI SEQ ID NO: 69 FGHGFEYWGQGTLVTVSS SEQ ID NO: 226 iPS: 361165 2A11.005 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGGGCCAGTCAGATTTTTACCAGCACCTACT GCAGCGTCTGGATTCAGTTTCAGTAGCTATGGC TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGA CCAGGCTCCTCATCTATGGTGCATCCAGCAGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG AGTAATAAATACTATGAAGACTCCGTGAAGGGC GGTCTGGGACAGACTTCACTCTCACCATCAGCA CGATTCACCATCTCCAGAGACAATTCCAAGAAC GATTGGAGCCTGAAGATTTTGCAGTGTATTACT ACGCTGTTTCTGCAAGTGAACAGCCTGAGAGCC GTCAGCAGTATGGTAGCTCACCTCGCTTCGGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGGG AAGGGACACGACTGGAGATTAAACGA ATTACGATTTTTGGTCATGGGTTTGAATATTGGG SEQ ID NO: 1640 GCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1797 AA EIVLTQSPGTLSLSPGERATLSCRASQIFTSTYLAW QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF HWVRQAPGKGLEWVAVIWYDASNKYYEDSVKG TLTISRLEPEDFAVYYCQQYGSSPRFGQGTRLEIKR RFTISRDNSKNTLFLQVNSLRAEDTAVYYCARGITI SEQ ID NO: 70 FGHGFEYWGQGTLVTVSS SEQ ID NO: 227 iPS: 361172 2G10_LC1. NA GAAATAGTGATGACGCAGTCTCCAGCCACCCTG CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG 003 TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCAGCATCTGGATTCACCTTCAGTAACTATGGC GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC ATGCACTGGGTCCGCCAGGCTCCAGGCGAGGGG AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC CTGGAGTGGGTGGCAGCTATATGGTTTGATGCA ACTGGTATCCCAGCCAGGTTCAGTGGCAGTGGG AGTGATAAATACTATGCAGACGCCGTGAAGGGC TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC CTGCAGTCTGAAGATTTTGCAGTTTATTACTGTC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC AGCAGTATAATAACTGGCCTCTCACTTTCGGCG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GAGGGACCAAGGTGGAGATCAAACGA CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG SEQ ID NO: 1641 GGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1798 AA EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM YQQKPGQAPRLLIYGAATRATGIPARFSGSGSGTE HWVRQAPGEGLEWVAAIWFDASDKYYADAVKG FTLTISSLQSEDFAVYYCQQYNNWPLTFGGGTKVE RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ IKR AIFGVVPDYWGQGTLVTVSS SEQ ID NO: 71 SEQ ID NO: 228 iPS: 361178 2G10_LC1. NA GAAATAGTGATGACGCAGTCTCCAGCCACCCTG CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG 004 TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCAGCATCTGGATTCACCTTCAGTAACTATGGC GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC ATGCACTGGGTCCGCCAGGCTCCAGGCGAGGGG AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC CTGGAGTGGGTGGCAGCTATATGGTTTGATGCA ACTGGTATCCCAGCCAGGTTCAGTGGCAGTGGG AGTGATAAATACTATGCAGACTCCGTGAAGGGC TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC CTGCAGTCTGAAGATTTTGCAGTTTATTACTGTC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC AGCAGTATAATAACTGGCCTCTCACTTTCGGCG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GAGGGACCAAGGTGGAGATCAAACGA CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG SEQ ID NO: 1642 GGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1799 AA EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM YQQKPGQAPRLLIYGAATRATGIPARFSGSGSGTE HWVRQAPGEGLEWVAAIWFDASDKYYADSVKG FTLTISSLQSEDFAVYYCQQYNNWPLTFGGGTKVE RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ IKR AIFGVVPDYWGQGTLVTVSS SEQ ID NO: 72 SEQ ID NO: 229 iPS: 361185 2G10_LC1. NA GAAATAGTGATGACGCAGTCTCCAGCCACCCTG CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG 005 TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCAGCATCTGGATTCACCTTCAGTAACTATGGC GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC ATGCACTGGGTCCGCCAGGCTCCAGGCGAGGGG AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC CTGGAGTGGGTGGCAGCTATATGGTTTGATGGA ACTGGTATCCCAGCCAGGTTCAGTGGCAGTGGG AGTGATAAATACTATGCAGACGCCGTGAAGGGC TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC CTGCAGTCTGAAGATTTTGCAGTTTATTACTGTC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC AGCAGTATAATAACTGGCCTCTCACTTTCGGCG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GAGGGACCAAGGTGGAGATCAAACGA CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG SEQ ID NO: 1643 GGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1800 AA EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM YQQKPGQAPRLLIYGAATRATGIPARFSGSGSGTE HWVRQAPGEGLEWVAAIWFDGSDKYYADAVKG FTLTISSLQSEDFAVYYCQQYNNWPLTFGGGTKVE RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ IKR AIFGVVPDYWGQGTLVTVSS SEQ ID NO: 73 SEQ ID NO: 230 iPS: 36192 2G10_LC1. NA GAAATAGTGATGACGCAGTCTCCAGCCACCCTG CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG 006 TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCAGCATCTGGATTCACCTTCAGTAACTATGGC GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC ATGCACTGGGTCCGCCAGGCTCCAGGCGAGGGG AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC CTGGAGTGGGTGGCAGCTATATGGTTTGATGCA ACTGGTATCCCAGCCAGGGTCAGTGGCAGTGGG AGTGATAAATACTATGCAGACGCCGTGAAGGGC TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC CTGCAGTCTGAAGATTTTGCAGTTTATTACTGTC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC AGCAGTATAATAACTGGCCTCTCACTTTCGGCG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GAGGGACCAAGGTGGAGATCAAACGA CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG SEQ ID NO: 1644 GGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1801 AA EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM YQQKPGQAPRLLIYGAATRATGIPARVSGSGSGTE HWVRQAPGEGLEWVAAIWFDASDKYYADAVKG FTLTISSLQSEDFAVYYCQQYNNWPLTFGGGTKVE RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ IKR AIFGVVPDYWGQGTLVTVSS SEQ ID NO: 74 SEQ ID NO: 231 iPS: 359609 2G10_LC1. NA GAAATAGTGATGACGCAGTCTCCAGCCACCCTG CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG 007 TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCAGCATCTGGATTCACCTTCAGTAACTATGGC GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC CTGGAGTGGGTGGCAGCTATATGGTTTGATGCA ACTGGTATCCCAGCCAGGTTCAGTGGCAGTGGG AGTGATAAATACTATGCAGACGCCGTGAAGGGC TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC CTGGAGCCTGAAGATTTTGCAGTTTATTACTGTC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC AGCAGTATAATAACTTCCCTCTCACTTTCGGCGG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT AGGGACCAAGGTGGAGATCAAACGA CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG SEQ ID NO: 1645 GGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1802 AA EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM YQQKPGQAPRLLIYGAATRATGIPARFSGSGSGTE HWVRQAPGKGLEWVAAIWFDASDKYYADAVKG FTLTISSLEPEDFAVYYCQQYNNFPLTFGGGTKVEI RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ KR AIFGVVPDYWGQGTLVTVSS SEQ ID NO: 75 SEQ ID NO: 232 iPS: 359615 2G10_LC1. NA GAAATAGTGATGACGCAGTCTCCAGCCACCCTG CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG 008 TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCAGCATCTGGATTCACCTTCAGTAACTATGGC GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC CTGGAGTGGGTGGCAGCTATATGGTTTGATGCA ACTGGTATCCCAGCCAGGTTCAGTGGCAGTGGG AGTGATAAATACTATGCAGACGCCGTGAAGGGC TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC CTGGAGCCTGAAGATTTTGCAGTTTATTACTGTC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC AGCAGTATAATAACTATCCTCTCACTTTCGGCGG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT AGGGACCAAGGTGGAGATCAAACGA CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG SEQ ID NO: 1646 GGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1803 AA EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM YQQKPGQAPRLLIYGAATRATGIPARFSGSGSGTE HWVRQAPGKGLEWVAAIWFDASDKYYADAVKG FTLTISSLEPEDFAVYYCQQYNNYPLTFGGGTKVEI RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ KR AIFGVVPDYWGQGTLVTVSS SEQ ID NO: 76 SEQ ID NO: 233 iPS: 361196 2G10_LC1. NA GAAATAGTGATGACGCAGTCTCCAGCCACCCTG CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG 009 TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCAGCATCTGGATTCACCTTCAGTAACTATGGC GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC ATGCACTGGGTCCGCCAGGCTCCAGGCGAGGGG AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC CTGGAGTGGGTGGCAGCTATATGGTTTGATGCA ACTGGTATCCCAGCCAGGTTCAGTGGCAGTGGG AGTGATAAATACTATGCAGACGCCGTGAAGGGC TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC CTGGAGCCTGAAGATTTTGCAGTTTATTACTGTC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC AGCAGTATAATAACTGGCCTCTCACTTTCGGCG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GAGGGACCAAGGTGGAGATCAAACGA CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG SEQ ID NO: 1647 GGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1804 AA EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM YQQKPGQAPRLLIYGAATRATGIPARFSGSGSGTE HWVRQAPGEGLEWVAAIWFDASDKYYADAVKG FTLTISSLEPEDFAVYYCQQYNNWPLTFGGGTKVE RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ IKR AIFGVVPDYWGQGTLVTVSS SEQ ID NO: 77 SEQ ID NO: 234 iPS: 361202 2G10_LC1. NA GAAATAGTGATGACGCAGTCTCCAGCCACCCTG CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG 010 TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCAGCATCTGGATTCACCTTCAGTAACTATGGC GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC CTGGAGTGGGTGGCAGCTATATGGTTTGATGCA ACTGGTATCCCAGCCAGGTTCAGTGGCAGTGGG AGTGATAAATACTATGCAGACGCCGTGAAGGGC TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC CTGGAGCCTGAAGATTTTGCAGTTTATTACTGTC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC AGCAGTATAATAACTGGCCTCTCACTTTCGGCG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GAGGGACCAAGGTGGAGATCAAACGA CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG SEQ ID NO: 1648 GGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1805 AA EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM YQQKPGQAPRLLIYGAATRATGIPARFSGSGSGTE HWVRQAPGKGLEWVAAIWFDASDKYYADAVKG FTLTISSLEPEDFAVYYCQQYNNWPLTFGGGTKVE RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ IKR AIFGVVPDYWGQGTLVTVSS SEQ ID NO: 78 SEQ ID NO: 235 iPS: 359644 18E3.002 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG CAGGTGCAGTTGCAGGAGTCGGGCCCAGGACTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GTGAAGCCTTCAGAGACCCTGTCCCTCACCTGC GCAGGGCCAGTCAGAGTATTAGTTACAGTTACT ACTGTCTCTGGTGACTCCATCAGCAGTGGTGGTT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC ACTACTGGAGCTGGATCCGCCAGCCCCCAGGGA CCCGGCTCCTCATCTATGGTGCATCCAGCAGGG AGGGCCTGGAGTGGATTGGGTACATCTATTACA CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GTGGGAGCACCTACTACAACCCGTCCCTCAAGA GGTCTGGGACAGACTTCACTCTCACCATCAGCA GTCGAGTTACCATATCAGTAGACACGTCTAAGA GACTGGAGCCTGATGATTTTGCAGTGTATTACTG ACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGC TCAGCAGTATGGTAGTTCACCGCTCACTTTCGGC CGCGGACACGGCCGTGTATTACTGTGCGAGAGA GGAGGGACCAAGGTGGAGATCAAACGA TCGTATTACGATTTTTGGAGTGGTTATGGGGGGC SEQ ID NO: 1649 GGTATGGACGTCTGGGGCCAAGGGACCACGGTC ACCGTCTCCTCA SEQ ID NO: 1806 AA EIVLTQSPGTLSLSPGERATLSCRASQSISYSYLAW QVQLQESGPGLVKPSETLSLTCTVSGDSISSGGYY YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF WSWIRQPPGKGLEWIGYIYYSGSTYYNPSLKSRVT TLTISRLEPDDFAVYYCQQYGSSPLTFGGGTKVEIK ISVDTSKNQFSLKLSSVTAADTAVYYCARDRITIFG R VVMGGGMDVWGQGTTVTVSS SEQ ID NO: 79 SEQ ID NO: 236 iPS: 361206 18E3.003 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG CAGGTGCAGTTGCAGGAGTCGGGCCCAGGACTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GTGAAGCCTTCAGAGACCCTGTCCCTCACCTGC GCAGGGCCAGTCAGAGTATTAGTTACAGTTACT ACTGTCTCTGGTGACTCCATCAGCAGTGGTGGTT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC ACTACTGGAGCTGGATCCGCCAGCCCCCAGGGA CCCGGCTCCTCATCTATGGTGCATCCAGCAGGG AGGGCCTGGAGTGGATTGGGTACATCTATTACA CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GTGGGAGCACCTACTACAACCCGTCCCTCAAGA GGTCTGGGACAGACTTCACTCTCACCATCAGCA GTCGAGTTACCATATCAGTAGACACGTCTAAGA GACAGGAGCCTGATGATTTTGCAGTGTATTACT ACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGC GTCAGCAGTATGGTAGTTCACCGCTCACTTTCGG CGCGGACACGGCCGTGTATTACTGTGCGAGAGA CGGAGGGACCAAGGTGGAGATCAAACGA TCGTATTACGATTTTTGGAGTGGTTATGGGGGGC SEQ ID NO: 1650 GGTATGGACGTCTGGGGCCAAGGGACCACGGTC ACCGTCTCCTCA SEQ ID NO: 1807 AA EIVLTQSPGTLSLSPGERATLSCRASQSISYSYLAW QVQLQESGPGLVKPSETLSLTCTVSGDSISSGGYY YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF WSWIRQPPGKGLEWIGYIYYSGSTYYNPSLKSRVT TLTISRQEPDDFAVYYCQQYGSSPLTFGGGTKVEI ISVDTSKNQFSLKLSSVTAADTAVYYCARDRITIFG KR VVMGGGMDVWGQGTTVTVSS SEQ ID NO: 80 SEQ ID NO: 237 iPS: 359628 18E3.004 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG CAGGTGCAGTTGCAGGAGTCGGGCCCAGGACTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GTGAAGCCTTCACAGACCCTGTCCCTCACCTGC GCAGGGCCAGTCAGAGTATTAGTTACAGTTACT ACTGTCTCTGGTGACTCCATCAGCAGTGGTGGTT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC ACTACTGGAGCTGGATCCGCCAGCCCCCAGGGA CCCGGCTCCTCATCTATGGTGCATCCAGCAGGG AGGGCCTGGAGTGGATTGGGTACATCTATTACA CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GTGGGAGCACCTACTACAACCCGTCCCTCAAGA GGTCTGGGACAGACTTCACTCTCACCATCAGCA GTCGAGTTACCATATCAGTAGACACGTCTAAGA GACTGGAGCCTGATGATTTTGCAGTGTATTACTG ACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGC TCAGCAGTATGGTAGTTCACCGCTCACTTTCGGC CGCGGACACGGCCGTGTATTACTGTGCGAGAGA GGAGGGACCAAGGTGGAGATCAAACGA TCGTATTACGATTTTTGGAGTGGTTATGGGGGGC SEQ ID NO: 1651 GGTATGGACGTCTGGGGCCAAGGGACCACGGTC ACCGTCTCCTCA SEQ ID NO: 1808 AA EIVLTQSPGTLSLSPGERATLSCRASQSISYSYLAW QVQLQESGPGLVKPSQTLSLTCTVSGDSISSGGYY YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF WSWIRQPPGKGLEWIGYIYYSGSTYYNPSLKSRVT TLTISRLEPDDFAVYYCQQYGSSPLTFGGGTKVEIK ISVDTSKNQFSLKLSSVTAADTAVYYCARDRITIFG R VVMGGGMDVWGQGTTVTVSS SEQ ID NO: 81 SEQ ID NO: 238 iPS: 359637 18E3.005 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG CAGGTGCAGTTGCAGGAGTCGGGCCCAGGACTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GTGAAGCCTTCAGAGACCCTGTCCCTCACCTGC GCAGGGCCAGTCAGAGTATTAGTTACAGTTACT ACTGTCTCTGGTGACTCCATCAGCAGTGGTGGTT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC ACTACTGGAGCTGGATCCGCCAGCACCCAGGGA CCCGGCTCCTCATCTATGGTGCATCCAGCAGGG AGGGCCTGGAGTGGATTGGGTACATCTATTACA CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GTGGGAGCACCTACTACAACCCGTCCCTCAAGA GGTCTGGGACAGACTTCACTCTCACCATCAGCA GTCGAGTTACCATATCAGTAGACACGTCTAAGA GACTGGAGCCTGATGATTTTGCAGTGTATTACTG ACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGC TCAGCAGTATGGTAGTTCACCGCTCACTTTCGGC CGCGGACACGGCCGTGTATTACTGTGCGAGAGA GGAGGGACCAAGGTGGAGATCAAACGA TCGTATTACGATTTTTGGAGTGGTTATGGGGGGC SEQ ID NO: 1652 GGTATGGACGTCTGGGGCCAAGGGACCACGGTC ACCGTCTCCTCA SEQ ID NO: 1809 AA EIVLTQSPGTLSLSPGERATLSCRASQSISYSYLAW QVQLQESGPGLVKPSETLSLTCTVSGDSISSGGYY YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF WSWIRQHPGKGLEWIGYIYYSGSTYYNPSLKSRVT TLTISRLEPDDFAVYYCQQYGSSPLTFGGGTKVEIK ISVDTSKNQFSLKLSSVTAADTAVYYCARDRITIFG R VVMGGGMDVWGQGTTVTVSS SEQ ID NO: 82 SEQ ID NO: 239 iPS: 361210 18E3.006 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG CAGGTGCAGTTGCAGGAGTCGGGCCCAGGACTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GTGAAGCCTTCACAGACCCTGTCCCTCACCTGC GCAGGGCCAGTCAGAGTATTAGTTACAGTTACT ACTGTCTCTGGTGACTCCATCAGCAGTGGTGGTT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC ACTACTGGAGCTGGATCCGCCAGCACCCAGGGA CCCGGCTCCTCATCTATGGTGCATCCAGCAGGG AGGGCCTGGAGTGGATTGGGTACATCTATTACA CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GTGGGAGCACCTACTACAACCCGTCCCTCAAGA GGTCTGGGACAGACTTCACTCTCACCATCAGCA GTCGAGTTACCATATCAGTAGACACGTCTAAGA GACTGGAGCCTGATGATTTTGCAGTGTATTACTG ACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGC TCAGCAGTATGGTAGTTCACCGCTCACTTTCGGC CGCGGACACGGCCGTGTATTACTGTGCGAGAGA GGAGGGACCAAGGTGGAGATCAAACGA TCGTATTACGATTTTTGGAGTGGTTATGGGGGGC SEQ ID NO: 1653 GGTATGGACGTCTGGGGCCAAGGGACCACGGTC ACCGTCTCCTCA SEQ ID NO: 1810 AA EIVLTQSPGTLSLSPGERATLSCRASQSISYSYLAW QVQLQESGPGLVKPSQTLSLTCTVSGDSISSGGYY YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF WSWIRQHPGKGLEWIGYIYYSGSTYYNPSLKSRVT TLTISRLEPDDFAVYYCQQYGSSPLTFGGGTKVEIK ISVDTSKNQFSLKLSSVTAADTAVYYCARDRITIFG R VVMGGGMDVWGQGTTVTVSS SEQ ID NO: 83 SEQ ID NO: 240 iPS: 361214 18E3.007 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG CAGGTGCAGTTGCAGGAGTCGGGCCCAGGACTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GTGAAGCCTTCAGAGACCCTGTCCCTCACCTGC GCAGGGCCAGTCAGAGTATTAGTTACAGTTACT ACTGTCTCTGGTGACTCCATCAGCAGTGGTGGTT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC ACTACTGGAGCTGGATCCGCCAGCACCCAGGGA CCCGGCTCCTCATCTATGGTGCATCCAGCAGGG AGGGCCTGGAGTGGATTGGGTACATCTATTACA CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GTGGGAGCACCTACTACAACCCGTCCCTCAAGA GGTCTGGGACAGACTTCACTCTCACCATCAGCA GTCGAGTTACCATATCAGTAGACACGTCTAAGA GACAGGAGCCTGATGATTTTGCAGTGTATTACT ACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGC GTCAGCAGTATGGTAGTTCACCGCTCACTTTCGG CGCGGACACGGCCGTGTATTACTGTGCGAGAGA CGGAGGGACCAAGGTGGAGATCAAACGA TCGTATTACGATTTTTGGAGTGGTTATGGGGGGC SEQ ID NO: 1654 GGTATGGACGTCTGGGGCCAAGGGACCACGGTC ACCGTCTCCTCA SEQ ID NO: 1811 AA EIVLTQSPGTLSLSPGERATLSCRASQSISYSYLAW QVQLQESGPGLVKPSETLSLTCTVSGDSISSGGYY YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF WSWIRQHPGKGLEWIGYIYYSGSTYYNPSLKSRVT TLTISRQEPDDFAVYYCQQYGSSPLTFGGGTKVEI ISVDTSKNQFSLKLSSVTAADTAVYYCARDRITIFG KR VVMGGGMDVWGQGTTVTVSS SEQ ID NO: 84 SEQ ID NO: 241 iPS: 361218 18E3.008 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG CAGGTGCAGTTGCAGGAGTCGGGCCCAGGACTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GTGAAGCCTTCACAGACCCTGTCCCTCACCTGC GCAGGGCCAGTCAGAGTATTAGTTACAGTTACT ACTGTCTCTGGTGACTCCATCAGCAGTGGTGGTT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC ACTACTGGAGCTGGATCCGCCAGCCCCCAGGGA CCCGGCTCCTCATCTATGGTGCATCCAGCAGGG AGGGCCTGGAGTGGATTGGGTACATCTATTACA CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GTGGGAGCACCTACTACAACCCGTCCCTCAAGA GGTCTGGGACAGACTTCACTCTCACCATCAGCA GTCGAGTTACCATATCAGTAGACACGTCTAAGA GACAGGAGCCTGATGATTTTGCAGTGTATTACT ACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGC GTCAGCAGTATGGTAGTTCACCGCTCACTTTCGG CGCGGACACGGCCGTGTATTACTGTGCGAGAGA CGGAGGGACCAAGGTGGAGATCAAACGA TCGTATTACGATTTTTGGAGTGGTTATGGGGGGC SEQ ID NO: 1655 GGTATGGACGTCTGGGGCCAAGGGACCACGGTC ACCGTCTCCTCA SEQ ID NO: 1812 AA EIVLTQSPGTLSLSPGERATLSCRASQSISYSYLAW QVQLQESGPGLVKPSQTLSLTCTVSGDSISSGGYY YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF WSWIRQPPGKGLEWIGYIYYSGSTYYNPSLKSRVT TLTISRQEPDDFAVYYCQQYGSSPLTFGGGTKVEI ISVDTSKNQFSLKLSSVTAADTAVYYCARDRITIFG KR VVMGGGMDVWGQGTTVTVSS SEQ ID NO: 85 SEQ ID NO: 242 iPS: 361222 5C2.006 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT CTTGAGTGGATGGGGTGGATCAACCCTGAAAGT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA AGGGTCACCATGACCAGGGACACGTCCATCAGC CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG ACAGCCTACATGGAACTGAACAGGCTGAGATCT TGGCAGTTTTTTACTGTCAACAATATTATAGTAC GACGACACGGCCGTGTATTACTGTGCGAGAGAG TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1656 CCTCA SEQ ID NO: 1813 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPESGGTDYSQRFQGR GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ VTMTRDTSISTAYMELNRLRSDDTAVYYCAREATI GTKVEIKR FGMVIVPFDYWGQGTLVTVSS SEQ ID NO: 86 SEQ ID NO: 243 iPS: 361229 5C2.007 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT CTTGAGTGGATGGGGTGGATCAACCCTGAAAGT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA AGGTTCACCATGACCAGGGACACGTCCATCAGC CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG ACAGCCTACATGGAACTGAACAGGCTGAGATCT TGGCAGTTTTTTACTGTCAACAATATTATAGTAC GACGACACGGCCGTGTATTACTGTGCGAGAGAG TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1657 CCTCA SEQ ID NO: 1814 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPESGGTDYSQRFQGR GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ FTMTRDTSISTAYMELNRLRSDDTAVYYCAREATI GTKVEIKR FGMVIVPFDYWGQGTLVTVSS SEQ ID NO: 87 SEQ ID NO: 244 iPS: 361236 5C2.008: NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT CTTGAGTGGATGGGGTGGATCAACCCTGACGCT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA AGGGTCACCATGACCAGGGACACGTCCATCAGC CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG ACAGCCTACATGGAACTGAACAGGCTGAGATCT TGGCAGTTTTTTACTGTCAACAATATTATAGTAC GACGACACGGCCGTGTATTACTGTGCGAGAGAG TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1658 CCTCA SEQ ID NO: 1815 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPDAGGTDYSQRFQG GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ RVTMTRDTSISTAYMELNRLRSDDTAVYYCAREA GTKVEIKR TIFGMVIVPFDYWGQGTLVTVSS SEQ ID NO: 88 SEQ ID NO: 245 iPS: 359685 5C2.009 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT CTTGAGTGGATGGGGTGGATCAACCCTGACGCT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA AGGTTCACCATGACCAGGGACACGTCCATCAGC CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG ACAGCCTACATGGAACTGAACAGGCTGAGATCT TGGCAGTTTTTTACTGTCAACAATATTATAGTAC GACGACACGGCCGTGTATTACTGTGCGAGAGAG TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1659 CCTCA SEQ ID NO: 1816 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPDAGGTDYSQRFQG GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ RFTMTRDTSISTAYMELNRLRSDDTAVYYCAREA GTKVEIKR TIFGMVIVPFDYWGQGTLVTVSS SEQ ID NO: 89 SEQ ID NO: 246 iPS: 361240 5C2.010 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT CTTGAGTGGATGGGGTGGATCAACCCTGACAGT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA AGGGTCACCATGACCAGGGACACGTCCATCAGC CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG ACAGCCTACATGGAACTGAACAGGCTGAGATCT TGGCAGTTTTTTACTGTCAACAATATTATAGTAC GACGACACGGCCGTGTATTACTGTGCGAGAGAG TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1660 CCTCA SEQ ID NO: 1817 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPDSGGTDYSQRFQGR GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ VTMTRDTSISTAYMELNRLRSDDTAVYYCAREATI GTKVEIKR FGMVIVPFDYWGQGTLVTVSS SEQ ID NO: 90 SEQ ID NO: 247 iPS: 361247 5C2.011 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT CTTGAGTGGATGGGGTGGATCAACCCTGACAGT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA AGGTTCACCATGACCAGGGACACGTCCATCAGC CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG ACAGCCTACATGGAACTGAACAGGCTGAGATCT TGGCAGTTTTTTACTGTCAACAATATTATAGTAC GACGACACGGCCGTGTATTACTGTGCGAGAGAG TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1661 CCTCA SEQ ID NO: 1818 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPDSGGTDYSQRFQGR GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ FTMTRDTSISTAYMELNRLRSDDTAVYYCAREATI GTKVEIKR FGMVIVPFDYWGQGTLVTVSS SEQ ID NO: 91 SEQ ID NO: 248 iPS: 361254 5C2.012 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT CTTGAGTGGATGGGGTGGATCAACCCTGACAGT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA AGGGTCACCATGACCAGGGACACGTCCATCAGC CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG ACAGCCTACATGGAACTGAACAGGCTGAGATCT TGGCAGTTTTTTACTGTCAACAATATTATAGTAC GACGACACGGCCGTGTATTACTGTGCGAGAGAG TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1662 CCTCA SEQ ID NO: 1819 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPDSGGTDYSQRFQGR GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ VTMTRDTSISTAYMELNRLRSDDTAVYYCAREATI GTKVEIKR FGMVIVPFDYWGQGTLVTVSS SEQ ID NO: 92 SEQ ID NO: 249 iPS: 361261 5C2.013 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT CTTGAGTGGATGGGGTGGATCAACCCTGACGCT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA AGGTTCACCATGACCAGGGACACGTCCATCAGC CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG ACAGCCTACATGGAACTGAACAGGCTGAGATCT TGGCAGTTTTTTACTGTCAACAATATTATAGTAC GACGACACGGCCGTGTATTACTGTGCGAGAGAG TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1663 CCTCA SEQ ID NO: 1820 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPDAGGTDYSQRFQG GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ RFTMTRDTSISTAYMELNRLRSDDTAVYYCAREA GTKVEIKR TIFGMVIVPFDYWGQGTLVTVSS SEQ ID NO: 93 SEQ ID NO: 250 iPS: 361268 5C2.014 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT CTTGAGTGGATGGGGTGGATCAACCCTGACGCT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA AGGGTCACCATGACCAGGGACACGTCCATCAGC CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG ACAGCCTACATGGAACTGAACAGGCTGAGATCT TGGCAGTTTTTTACTGTCAACAATATTATAGTAC GACGACACGGCCGTGTATTACTGTGCGAGAGAG TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1664 CCTCA SEQ ID NO: 1821 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPDAGGTDYSQRFQG GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ RVTMTRDTSISTAYMELNRLRSDDTAVYYCAREA GTKVEIKR TIFGMVIVPFDYWGQGTLVTVSS SEQ ID NO: 94 SEQ ID NO: 251 iPS: 359669 5C2.015 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG AAACCAGGACAACCTCCTAAGCTGCTCATTTAC CTTGAGTGGATGGGGTGGATCAACCCTGACGCT TGGGCATCTACCCGGGAATCCGGGGTCCCTGAC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAGCAGCCTGCAGGCTGAAGAT ACAGCCTACATGGAACTGAACAGCCTGAGATCT GTGGCAGTTTTTTACTGTCAACAATATTATAGTA GACGACACGGCCGTGTATTACTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AAATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1665 CCTCA SEQ ID NO: 1822 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQKPGQPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPDAGGTDYSQRFQG GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ RVTMTRDTSISTAYMELNSLRSDDTAVYYCAREA GTKVEIKR TIFGMVIVPFDYWGQGTLVTVSS SEQ ID NO: 95 SEQ ID NO: 252 iPS: 359678 5C2.016 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG AAACCAGGACAACCTCCTAAGCTGCTCATTTAC CTTGAGTGGATGGGGTGGATCAACCCTGAAAGT TGGGCATCTACCCGGGAATCCGGGGTCCCTGAC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAGCAGCCTGCAGGCTGAAGAT ACAGCCTACATGGAACTGAACAGCCTGAGATCT GTGGCAGTTTTTTACTGTCAACAATATTATAGTA GACGACACGGCCGTGTATTACTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AAATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1666 CCTCA SEQ ID NO: 1823 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQKPGQPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPESGGTDYSQRFQGR GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ VTMTRDTSISTAYMELNSLRSDDTAVYYCAREATI GTKVEIKR FGMVIVPFDYWGQGTLVTVSS SEQ ID NO: 96 SEQ ID NO: 253 iPS: 361275 11C1.002 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTACAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAACAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGTGTGGATGGGGTGGATCAGCCCTAACAGT TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC GGTGAAACAAGCTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTTCTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1667 CCTCA SEQ ID NO: 1824 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG HWVRQAPGQGLVWMGWISPNSGETSYAQKFQDR SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF VTMTRDTSISTAYMELSRLRSDDTAVYFCAREATI GQGTKVEIKR FGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 97 SEQ ID NO: 254 iPS: 361282 11C1.003 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTACAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAACAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGTGTGGATGGGGTGGATCAGCCCTAACAGT TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC GGTGACACAAGCTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTTCTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1668 CCTCA SEQ ID NO: 1825 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG HWVRQAPGQGLVWMGWISPNSGDTSYAQKFQDR SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF VTMTRDTSISTAYMELSRLRSDDTAVYFCAREATI GQGTKVEIKR FGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 98 SEQ ID NO: 255 iPS: 361289 11C1.004 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTACAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAACAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGTGTGGATGGGGTGGATCAGCCCTAACAGT TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC GGTGAAACAAGCTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTTCTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1669 CCTCA SEQ ID NO: 1826 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG HWVRQAPGQGLVWMGWISPNSGETSYAQKFQDR SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF VTMTRDTSISTAYMELSRLRSDDTAVYFCAREATI GQGTKVEIKR FGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 99 SEQ ID NO: 256 iPS: 359712 11C1.005 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTACAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAACAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGTGTGGATGGGGTGGATCAGCCCTAACAGT TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC GGTGAAACAAGCTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTTCTGTACGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1670 CCTCA SEQ ID NO: 1827 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG HWVRQAPGQGLVWMGWISPNSGETSYAQKFQDR SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF VTMTRDTSISTAYMELSRLRSDDTAVYFCTREATI GQGTKVEIKR FGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 100 SEQ ID NO: 257 iPS: 361293 11C1.006 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTACAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAACAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGTGTGGATGGGGTGGATCAGCCCTAACAGT TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC GGTGACACAAGCTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTTCTGTACGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1671 CCTCA SEQ ID NO: 1828 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG HWVRQAPGQGLVWMGWISPNSGDTSYAQKFQDR SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF VTMTRDTSISTAYMELSRLRSDDTAVYFCTREATI GQGTKVEIKR FGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 101 SEQ ID NO: 258 iPS: 361297 11C1.007 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTACAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAACAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGTGTGGATGGGGTGGATCAGCCCTAACAGT TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC GGTGAAACAAGCTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTTCTGTACGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1672 CCTCA SEQ ID NO: 1829 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG HWVRQAPGQGLVWMGWISPNSGETSYAQKFQDR SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF VTMTRDTSISTAYMELSRLRSDDTAVYFCTREATI GQGTKVEIKR FGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 102 SEQ ID NO: 259 iPS: 361301 11C1.008 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTACAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAACAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGTGTGGATGGGGTGGATCAGCCCTAACAGT TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC GGTGACACAAGCTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTTCTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1673 CCTCA SEQ ID NO: 1830 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG HWVRQAPGQGLVWMGWISPNSGDTSYAQKFQDR SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF VTMTRDTSISTAYMELSRLRSDDTAVYFCAREATI GQGTKVEIKR FGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 103 SEQ ID NO: 260 iPS: 359703 11C1.009 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCAGCTGGTACAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAACAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAAACTGCTCATTTAC CTTGAGTGGATGGGGTGGATCAGCCCTAACAGT TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC GGTGAAACAAGCTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGCCTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTTCTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1674 CCTCA SEQ ID NO: 1831 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPKLLIYWTSTRESGVPDRFSG HWVRQAPGQGLEWMGWISPNSGETSYAQKFQDR SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF VTMTRDTSISTAYMELSSLRSDDTAVYFCAREATI GQGTKVEIKR FGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 104 SEQ ID NO: 261 iPS: 361305 11C1.010 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCAGCTGGTACAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAACAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGAGTGGATGGGGTGGATCAGCCCTAACAGT TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC GGTGAAACAAGCTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTTCTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1675 CCTCA SEQ ID NO: 1832 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG HWVRQAPGQGLEWMGWISPNSGETSYAQKFQDR SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF VTMTRDTSISTAYMELSRLRSDDTAVYFCAREATI GQGTKVEIKR FGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 105 SEQ ID NO: 262 iPS: 361312 13H12.002 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGA AAACCAGGACATCCTCCTAAGCTGCTCATTTACT CTTGAGTGGATGGGGTGGATCAACCCTGAAAGT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA AGGGTCACCATGACCAGGGACACGTCCATCAGC CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG ACAGCCTACATGGAACTGAGCAGGCTGAGATCT TGGCAGTTTTTTACTGTCAACAATATTATAGTAC GACGACACGGCCGTGTATTACTGTGCGAGAGAG TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1676 CCTCA SEQ ID NO: 1833 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQKPGHPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPESGGTDYSQRFQGR GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ VTMTRDTSISTAYMELSRLRSDDTAVYYCAREATI GTKVEIKR FGMVIVPFDYWGQGTLVTVSS SEQ ID NO: 106 SEQ ID NO: 263 iPS: 359744 13H12.003 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGA AAACCAGGACATCCTCCTAAGCTGCTCATTTACT CTTGAGTGGATGGGGTGGATCAACCCTGAAAGT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA AGGTTCACCATGACCAGGGACACGTCCATCAGC CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG ACAGCCTACATGGAACTGAGCAGGCTGAGATCT TGGCAGTTTTTTACTGTCAACAATATTATAGTAC GACGACACGGCCGTGTATTACTGTGCGAGAGAG TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1677 CCTCA SEQ ID NO: 1834 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQKPGHPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPESGGTDYSQRFQGR GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ FTMTRDTSISTAYMELSRLRSDDTAVYYCAREATI GTKVEIKR FGMVIVPFDYWGQGTLVTVSS SEQ ID NO: 107 SEQ ID NO: 264 iPS: 361319 13H12.004 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGA AAACCAGGACATCCTCCTAAGCTGCTCATTTACT CTTGAGTGGATGGGGTGGATCAACCCTGACAGT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA AGGGTCACCATGACCAGGGACACGTCCATCAGC CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG ACAGCCTACATGGAACTGAGCAGGCTGAGATCT TGGCAGTTTTTTACTGTCAACAATATTATAGTAC GACGACACGGCCGTGTATTACTGTGCGAGAGAG TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1678 CCTCA SEQ ID NO: 1835 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQKPGHPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPDSGGTDYSQRFQGR GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ VTMTRDTSISTAYMELSRLRSDDTAVYYCAREATI GTKVEIKR FGMVIVPFDYWGQGTLVTVSS SEQ ID NO: 108 SEQ ID NO: 265 iPS: 359737 13H12.005 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGA AAACCAGGACAACCTCCTAAGCTGCTCATTTAC CTTGAGTGGATGGGGTGGATCAACCCTGAAAGT TGGGCATCTACCCGGGAATCCGGGGTCCCTGAC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAGCAGCCTGCAGGCTGAAGAT ACAGCCTACATGGAACTGAGCAGCCTGAGATCT GTGGCAGTTTTTTACTGTCAACAATATTATAGTA GACGACACGGCCGTGTATTACTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AAATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1679 CCTCA SEQ ID NO: 1836 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQKPGQPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPESGGTDYSQRFQGR GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ VTMTRDTSISTAYMELSSLRSDDTAVYYCAREATI GTKVEIKR FGMVIVPFDYWGQGTLVTVSS SEQ ID NO: 109 SEQ ID NO: 266 iPS: 361326 13H12.006 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGA AAACCAGGACAACCTCCTAAGCTGCTCATTTAC CTTGAGTGGATGGGGTGGATCAACCCTGAAAGT TGGGCATCTACCCGGGAATCCGGGGTCCCTGAC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAGCAGCCTGCAGGCTGAAGAT ACAGCCTACATGGAACTGAGCAGGCTGAGATCT GTGGCAGTTTTTTACTGTCAACAATATTATAGTA GACGACACGGCCGTGTATTACTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AAATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1680 CCTCA SEQ ID NO: 1837 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQKPGQPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPESGGTDYSQRFQGR GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ VTMTRDTSISTAYMELSRLRSDDTAVYYCAREATI GTKVEIKR FGMVIVPFDYWGQGTLVTVSS SEQ ID NO: 110 SEQ ID NO: 267 iPS: 361330 12H11.002 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAGCAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGAGTGGATGGGGTGGATAAGCCCTAACCAA TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC GGTGAAACAAACTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTACTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1681 CCTCA SEQ ID NO: 1838 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG HWVRQAPGQGLEWMGWISPNQGETNYAQKFQD SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF RVTMTRDTSISTAYMELSRLRSDDTAVYYCAREA GQGTKVEIKR TIFGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 111 SEQ ID NO: 268 iPS: 361337 12H11.003 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAGCAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGAGTGGATGGGGTGGATAAGCCCTAACCAA TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC GGTGACACAAACTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTACTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1682 CCTCA SEQ ID NO: 1839 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG HWVRQAPGQGLEWMGWISPNQGDTNYAQKFQD SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF RVTMTRDTSISTAYMELSRLRSDDTAVYYCAREA GQGTKVEIKR TIFGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 112 SEQ ID NO: 269 iPS: 361344 12H11.004 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAGCAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGAGTGGATGGGGTGGATAAGCCCTAACCAA TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC GGTGAAACAAACTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTACTGTACGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1683 CCTCA SEQ ID NO: 1840 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG HWVRQAPGQGLEWMGWISPNQGETNYAQKFQD SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF RVTMTRDTSISTAYMELSRLRSDDTAVYYCTREA GQGTKVEIKR TIFGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 113 SEQ ID NO: 270 iPS: 361351 12H11.005 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAGCAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGAGTGGATGGGGTGGATAAGCCCTAACAAT TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC GGTGAAACAAACTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTACTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1684 CCTCA SEQ ID NO: 1841 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG HWVRQAPGQGLEWMGWISPNNGETNYAQKFQD SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF RVTMTRDTSISTAYMELSRLRSDDTAVYYCAREA GQGTKVEIKR TIFGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 114 SEQ ID NO: 271 iPS: 361358 12H11.006 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAGCAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGAGTGGATGGGGTGGATAAGCCCTAACAAT TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC GGTGACACAAACTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTACTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1685 CCTCA SEQ ID NO: 1842 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG HWVRQAPGQGLEWMGWISPNNGDTNYAQKFQD SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF RVTMTRDTSISTAYMELSRLRSDDTAVYYCAREA GQGTKVEIKR TIFGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 115 SEQ ID NO: 272 iPS: 361365 12H11.007 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAGCAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGAGTGGATGGGGTGGATAAGCCCTAACCAA TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC GGTGACACAAACTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTACTGTACGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1686 CCTCA SEQ ID NO: 1843 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG HWVRQAPGQGLEWMGWISPNQGDTNYAQKFQD SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF RVTMTRDTSISTAYMELSRLRSDDTAVYYCTREA GQGTKVEIKR TIFGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 116 SEQ ID NO: 273 iPS: 361372 12H11.008 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAGCAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGAGTGGATGGGGTGGATAAGCCCTAACAAT TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC GGTGAAACAAACTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTACTGTACGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1687 CCTCA SEQ ID NO: 1844 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG HWVRQAPGQGLEWMGWISPNNGETNYAQKFQD SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF RVTMTRDTSISTAYMELSRLRSDDTAVYYCTREA GQGTKVEIKR TIFGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 117 SEQ ID NO: 274 iPS: 361379 12H11.009 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAGCAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGAGTGGATGGGGTGGATAAGCCCTAACCAA TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC GGTGAAACAAACTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTACTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1688 CCTCA SEQ ID NO: 1845 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG HWVRQAPGQGLEWMGWISPNQGETNYAQKFQD SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF RVTMTRDTSISTAYMELSRLRSDDTAVYYCAREA GQGTKVEIKR TIFGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 118 SEQ ID NO: 275 iPS: 361383 12H11.010 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAGCAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGAGTGGATGGGGTGGATAAGCCCTAACAAT TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC GGTGACACAAACTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTACTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1689 CCTCA SEQ ID NO: 1846 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG HWVRQAPGQGLEWMGWISPNNGDTNYAQKFQD SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF RVTMTRDTSISTAYMELSRLRSDDTAVYYCAREA GQGTKVEIKR TIFGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 119 SEQ ID NO: 276 iPS: 361387 12H11.011 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAGCAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGAGTGGATGGGGTGGATAAGCCCTAACCAA TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC GGTGACACAAACTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTACTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1690 CCTCA SEQ ID NO: 1847 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG HWVRQAPGQGLEWMGWISPNQGDTNYAQKFQD SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF RVTMTRDTSISTAYMELSRLRSDDTAVYYCAREA GQGTKVEIKR TIFGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 120 SEQ ID NO: 277 iPS: 361391 12H11.012 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAGCAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGAGTGGATGGGGTGGATAAGCCCTAACAAT TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC GGTGAAACAAACTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTACTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1691 CCTCA SEQ ID NO: 1848 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG HWVRQAPGQGLEWMGWISPNNGETNYAQKFQD SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF RVTMTRDTSISTAYMELSRLRSDDTAVYYCAREA GQGTKVEIKR TIFGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 121 SEQ ID NO: 278 iPS: 361395 12H11.013 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAGCAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAAACTGCTCATTTAC CTTGAGTGGATGGGGTGGATAAGCCCTAACCAA TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC GGTGAAACAAACTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGCCTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTACTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1692 CCTCA SEQ ID NO: 1849 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPKLLIYWTSTRDSGVPDRFSG HWVRQAPGQGLEWMGWISPNQGETNYAQKFQD SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF RVTMTRDTSISTAYMELSSLRSDDTAVYYCAREA GQGTKVEIKR TIFGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 122 SEQ ID NO: 279 iPS: 361402 12H11.014 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAGCAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAAACTGCTCATTTAC CTTGAGTGGATGGGGTGGATAAGCCCTAACCAA TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC GGTGAAACAAACTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGCCTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTACTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGA ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT SEQ ID NO: 1693 CCTCA SEQ ID NO: 1850 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPKLLIYWTSTRESGVPDRFSG HWVRQAPGQGLEWMGWISPNQGETNYAQKFQD SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF RVTMTRDTSISTAYMELSSLRSDDTAVYYCAREA GQGTKVEIKR TIFGMLIVPFDYWGQGTLVTVSS SEQ ID NO: 123 SEQ ID NO: 280 iPS: 361406 2C2.005. NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG 001 GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGTAGCTCCAACATCGGAAGTCAAACTG AAGGCTTCCGGATACACCTTCACCGGCTACTAT TAAACTGGTACCAGCACCTCCCAGGAACGGCCC ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATCTATACTAATAATCAGCGGC CTTGAGTGGATGGGATGGATCAACCCTAACAGT CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GGTGGCACAAACTATGCACAGAAGTTTCAGGGC GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG AGGGTCACCATGACCAGGGACACGTCCATCAGT CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT CAACATTCGATGAAAGCCTGAGTGGTCCGGTAT GACGACACGGCCGTGTATTACTGTGCGAGAGGG TCGGCGGAGGGACCAAGCTGACCGTCCTAGGT GGGGATTACGTTTGGGGGACTTATCGGCCTCAC SEQ ID NO: 1694 TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCA SEQ ID NO: 1851 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSQTVNW QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ ASLAISGLQSEDEADYFCATFDESLSGPVFGGGTK GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG LTVLG GDYVWGTYRPHYYYGMDVWGQGTTVTVSS SEQ ID NO: 124 SEQ ID NO: 281 iPS: 361412 2C2.005. NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG 002 GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGTAGCTCCAACATCGGAAGTCAAACTG AAGGCTTCCGGATACACCTTCACCGGCTACTAT TAAACTGGTACCAGCACCTCCCAGGAACGGCCC ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATCTATACTAATAATCAGCGGC CTTGAGTGGATGGGATGGATCAACCCTAACAGT CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GGTGGCACAAACTATGCACAGAAGTTTCAGGGC GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG AGGGTCACCATGACCAGGGACACGTCCATCAGT CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT CAACATTCGATGAAAGCCTGCAAGGTCCGGTAT GACGACACGGCCGTGTATTACTGTGCGAGAGGG TCGGCGGAGGGACCAAGCTGACCGTCCTAGGT GGGGATTACGTTTGGGGGACTTATCGGCCTCAC SEQ ID NO: 1695 TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCA SEQ ID NO: 1852 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSQTVNW QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ ASLAISGLQSEDEADYFCATFDESLQGPVFGGGTK GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG LTVLG GDYVWGTYRPHYYYGMDVWGQGTTVTVSS SEQ ID NO: 125 SEQ ID NO: 282 iPS: 361418 2C2.005. NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG 003 GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGTAGCTCCAACATCGGAAGTAATTATG AAGGCTTCCGGATACACCTTCACCGGCTACTAT TAAACTGGTACCAGCACCTCCCAGGAACGGCCC ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATCTATACTAATAATCAGCGGC CTTGAGTGGATGGGATGGATCAACCCTAACAGT CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GGTGGCACAAACTATGCACAGAAGTTTCAGGGC GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG AGGGTCACCATGACCAGGGACACGTCCATCAGT CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT CAACATTCGATGAAAGCCTGAGTGGTCCGGTAT GACGACACGGCCGTGTATTACTGTGCGAGAGGG TCGGCGGAGGGACCAAGCTGACCGTCCTAGGT GGGGATTACGTTTGGGGGACTTATCGGCCTCAC SEQ ID NO: 1696 TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCA SEQ ID NO: 1853 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNYVNW QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ ASLAISGLQSEDEADYFCATFDESLSGPVFGGGTK GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG LTVLG GDYVWGTYRPHYYYGMDVWGQGTTVTVSS SEQ ID NO: 126 SEQ ID NO: 283 iPS: 361424 2C2.005. NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG 004 GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGTAGCTCCAACATCGGAAGTAATTATG AAGGCTTCCGGATACACCTTCACCGGCTACTAT TAAACTGGTACCAGCACCTCCCAGGAACGGCCC ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATCTATACTAATAATCAGCGGC CTTGAGTGGATGGGATGGATCAACCCTAACAGT CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GGTGGCACAAACTATGCACAGAAGTTTCAGGGC GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG AGGGTCACCATGACCAGGGACACGTCCATCAGT CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT CAACATTCGATGAAAGCCTGCAAGGTCCGGTAT GACGACACGGCCGTGTATTACTGTGCGAGAGGG TCGGCGGAGGGACCAAGCTGACCGTCCTAGGT GGGGATTACGTTTGGGGGACTTATCGGCCTCAC SEQ ID NO: 1697 TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCA SEQ ID NO: 1854 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNYVNW QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ ASLAISGLQSEDEADYFCATFDESLQGPVFGGGTK GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG LTVLG GDYVWGTYRPHYYYGMDVWGQGTTVTVSS SEQ ID NO: 127 SEQ ID NO: 284 iPS: 361430 2C2.005. NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG 005 GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGTAGCTCCAACATCGGAAGTCAAACTG AAGGCTTCCGGATACACCTTCACCGGCTACTAT TAAACTGGTACCAGCACCTCCCAGGAACGGCCC ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATCTATACTAATAATCAGCGGC CTTGAGTGGATGGGATGGATCAACCCTAACAGT CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GGTGGCACAAACTATGCACAGAAGTTTCAGGGC GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG AGGGTCACCATGACCAGGGACACGTCCATCAGT CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT CAACATTCGATGACAGCCTGAATGGTCCGGTAT GACGACACGGCCGTGTATTACTGTGCGAGAGGG TCGGCGGAGGGACCAAGCTGACCGTCCTAGGT GGGGATTACGTTTGGGGGACTTATCGGCCTCAC SEQ ID NO: 1698 TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCA SEQ ID NO: 1855 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSQTVNW QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ ASLAISGLQSEDEADYFCATFDDSLNGPVFGGGTK GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG LTVLG GDYVWGTYRPHYYYGMDVWGQGTTVTVSS SEQ ID NO: 128 SEQ ID NO: 285 iPS: 361436 2C2.005. NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG 006 GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGTAGCTCCAACATCGGAAGTAATTATG AAGGCTTCCGGATACACCTTCACCGGCTACTAT TAAACTGGTACCAGCACCTCCCAGGAACGGCCC ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATCTATACTAATAATCAGCGGC CTTGAGTGGATGGGATGGATCAACCCTAACAGT CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GGTGGCACAAACTATGCACAGAAGTTTCAGGGC GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG AGGGTCACCATGACCAGGGACACGTCCATCAGT CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT CAACATTCGATGACAGCCTGAATGGTCCGGTAT GACGACACGGCCGTGTATTACTGTGCGAGAGGG TCGGCGGAGGGACCAAGCTGACCGTCCTAGGT GGGGATTACGTTTGGGGGACTTATCGGCCTCAC SEQ ID NO: 1699 TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCA SEQ ID NO: 1856 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNYVNW QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ ASLAISGLQSEDEADYFCATFDDSLNGPVFGGGTK GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG LTVLG GDYVWGTYRPHYYYGMDVWGQGTTVTVSS SEQ ID NO: 129 SEQ ID NO: 286 iPS: 361442 2C2.005. NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG 007 GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGTAGCTCCAACATCGGAAGTAATACTG AAGGCTTCCGGATACACCTTCACCGGCTACTAT TAAACTGGTACCAGCACCTCCCAGGAACGGCCC ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATCTATACTAATAATCAGCGGC CTTGAGTGGATGGGATGGATCAACCCTAACAGT CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GGTGGCACAAACTATGCACAGAAGTTTCAGGGC GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG AGGGTCACCATGACCAGGGACACGTCCATCAGT CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT CAACATTCGATGAAAGCCTGAATGGTCCGGTAT GACGACACGGCCGTGTATTACTGTGCGAGAGGG TCGGCGGAGGGACCAAGCTGACCGTCCTAGGT GGGGATTACGTTTGGGGGACTTATCGGCCTCAC SEQ ID NO: 1700 TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCA SEQ ID NO: 1857 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNW QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ ASLAISGLQSEDEADYFCATFDESLNGPVFGGGTK GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG LTVLG GDYVWGTYRPHYYYGMDVWGQGTTVTVSS SEQ ID NO: 130 SEQ ID NO: 287 iPS: 361448 2C2.005. NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG 008 GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGTAGCTCCAACATCGGAAGTAATACTG AAGGCTTCCGGATACACCTTCACCGGCTACTAT TAAACTGGTACCAGCACCTCCCAGGAACGGCCC ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATCTATACTAATAATCAGCGGC CTTGAGTGGATGGGATGGATCAACCCTAACAGT CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GGTGGCACAAACTATGCACAGAAGTTTCAGGGC GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG AGGGTCACCATGACCAGGGACACGTCCATCAGT CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT CAACATTCGATGACAGCCTGCAAGGTCCGGTAT GACGACACGGCCGTGTATTACTGTGCGAGAGGG TCGGCGGAGGGACCAAGCTGACCGTCCTAGGT GGGGATTACGTTTGGGGGACTTATCGGCCTCAC SEQ ID NO: 1701 TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCA SEQ ID NO: 1858 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNW QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ ASLAISGLQSEDEADYFCATFDDSLQGPVFGGGTK GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG LTVLG GDYVWGTYRPHYYYGMDVWGQGTTVTVSS SEQ ID NO: 131 SEQ ID NO: 288 iPS: 361454 2C2.005. NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG 009 GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGTAGCTCCAACATCGGAAGTAATACTG AAGGCTTCCGGATACACCTTCACCGGCTACTAT TAAACTGGTACCAGCACCTCCCAGGAACGGCCC ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATCTATACTAATAATCAGCGGC CTTGAGTGGATGGGATGGATCAACCCTAACAGT CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GGTGGCACAAACTATGCACAGAAGTTTCAGGGC GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG AGGGTCACCATGACCAGGGACACGTCCATCAGT CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT CAACATTCGATGACAGCCTGAGTGGTCCGGTAT GACGACACGGCCGTGTATTACTGTGCGAGAGGG TCGGCGGAGGGACCAAGCTGACCGTCCTAGGT GGGGATTACGTTTGGGGGACTTATCGGCCTCAC SEQ ID NO: 1702 TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCA SEQ ID NO: 1859 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNW QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ ASLAISGLQSEDEADYFCATFDDSLSGPVFGGGTK GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG LTVLG GDYVWGTYRPHYYYGMDVWGQGTTVTVSS SEQ ID NO: 132 SEQ ID NO: 289 iPS: 361460 2C2.005. NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG 010 GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGTAGCTCCAACATCGGAAGTAATACTG AAGGCTTCCGGATACACCTTCACCGGCTACTAT TAAACTGGTACCAGCACCTCCCAGGAACGGCCC ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATCTATACTAATAATCAGCGGC CTTGAGTGGATGGGATGGATCAACCCTAACAGT CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GGTGGCACAAACTATGCACAGAAGTTTCAGGGC GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG AGGGTCACCATGACCAGGGACACGTCCATCAGT CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT CAACATTCGATGACAGCCTGAATGCTCCGGTAT GACGACACGGCCGTGTATTACTGTGCGAGAGGG TCGGCGGAGGGACCAAGCTGACCGTCCTAGGT GGGGATTACGTTTGGGGGACTTATCGGCCTCAC SEQ ID NO: 1703 TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCA SEQ ID NO: 1860 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNW QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ ASLAISGLQSEDEADYFCATFDDSLNAPVFGGGTK GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG LTVLG GDYVWGTYRPHYYYGMDVWGQGTTVTVSS SEQ ID NO: 133 SEQ ID NO: 290 iPS: 361466 2C2.005. NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG 011 GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGTAGCTCCAACATCGGAAGTAATACTG AAGGCTTCCGGATACACCTTCACCGGCTACTAT TAAACTGGTACCAGCACCTCCCAGGAACGGCCC ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATCTATACTAATAATCAGCGGC CTTGAGTGGATGGGATGGATCAACCCTAACAGT CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GGTGGCACAAACTATGCACAGAAGTTTCAGGGC GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG AGGGTCACCATGACCAGGGACACGTCCATCAGT CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT CAACATTCGATAGCAGCCTGAATGGTCCGGTAT GACGACACGGCCGTGTATTACTGTGCGAGAGGG TCGGCGGAGGGACCAAGCTGACCGTCCTAGGT GGGGATTACGTTTGGGGGACTTATCGGCCTCAC SEQ ID NO: 1704 TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCA SEQ ID NO: 1861 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNW QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ ASLAISGLQSEDEADYFCATFDSSLNGPVFGGGTK GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG LTVLG GDYVWGTYRPHYYYGMDVWGQGTTVTVSS SEQ ID NO: 134 SEQ ID NO: 291 iPS: 361472 2C2.005. NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG 012 GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGTAGCTCCAACATCGGAAGTAATTATG AAGGCTTCCGGATACACCTTCACCGGCTACTAT TAAACTGGTACCAGCACCTCCCAGGAACGGCCC ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATCTATACTAATAATCAGCGGC CTTGAGTGGATGGGATGGATCAACCCTAACAGT CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GGTGGCACAAACTATGCACAGAAGTTTCAGGGC GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG AGGGTCACCATGACCAGGGACACGTCCATCAGT CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT CAACATTCGATAGCAGCCTGAATGCTCCGGTAT GACGACACGGCCGTGTATTACTGTGCGAGAGGG TCGGCGGAGGGACCAAGCTGACCGTCCTAGGT GGGGATTACGTTTGGGGGACTTATCGGCCTCAC SEQ ID NO: 1705 TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCA SEQ ID NO: 1862 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNYVNW QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ ASLAISGLQSEDEADYFCATFDSSLNAPVFGGGTK GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG LTVLG GDYVWGTYRPHYYYGMDVWGQGTTVTVSS SEQ ID NO: 135 SEQ ID NO: 292 iPS: 361478 2C2.005. NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG 013 GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGTAGCTCCAACATCGGAAGTAATTATG AAGGCTTCCGGATACACCTTCACCGGCTACTAT TAAACTGGTACCAGCACCTCCCAGGAACGGCCC ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATCTATACTAATAATCAGCGGC CTTGAGTGGATGGGATGGATCAACCCTAACAGT CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GGTGGCACAAACTATGCACAGAAGTTTCAGGGC GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG AGGGTCACCATGACCAGGGACACGTCCATCAGT CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG ACAGCCTACATGGAGCTGAGCAGCCTGAGGTCT CAACATTCGATAGCAGCCTGAATGCTCCGGTAT GACGACACGGCCGTGTATTACTGTGCGAGAGGG TCGGCGGAGGGACCAAGCTGACCGTCCTAGGT GGGGATTACGTTTTCGGGACTTATCGGCCTCACT SEQ ID NO: 1706 ACTACTACGGTATGGACGTCTGGGGCCAAGGGA CCACGGTCACCGTCTCCTCA SEQ ID NO: 1863 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNYVNW QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ ASLAISGLQSEDEADYFCATFDSSLNAPVFGGGTK GRVTMTRDTSISTAYMELSSLRSDDTAVYYCARG LTVLG GDYVFGTYRPHYYYGMDVWGQGTTVTVSS SEQ ID NO: 136 SEQ ID NO: 293 iPS: 361485 2C2.005. NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG 014 GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGTAGCTCCAACATCGGAAGTCAAACTG AAGGCTTCCGGATACACCTTCACCGGCTACTAT TAAACTGGTACCAGCACCTCCCAGGAACGGCCC ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATCTATACTAATAATCAGCGGC CTTGAGTGGATGGGATGGATCAACCCTAACAGT CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GGTGGCACAAACTATGCACAGAAGTTTCAGGGC GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG AGGGTCACCATGACCAGGGACACGTCCATCAGT CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT CAACATTCGATGAAAGCCTGAGTGGTCCGGTAT GACGACACGGCCGTGTATTACTGTGCGAGAGGG TCGGCGGAGGGACCAAGCTGACCGTCCTAGGT GGGGATTACGTTTTCGGGACTTATCGGCCTCACT SEQ ID NO: 1707 ACTACTACGGTATGGACGTCTGGGGCCAAGGGA CCACGGTCACCGTCTCCTCA SEQ ID NO: 1864 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSQTVNW QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ ASLAISGLQSEDEADYFCATFDESLSGPVFGGGTK GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG LTVLG GDYVFGTYRPHYYYGMDVWGQGTTVTVSS SEQ ID NO: 137 SEQ ID NO: 294 iPS: 361845 18F2.013 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCAA AGGACACGGCTGTGTATTACTGTGCGAGAGATA GGGACCAAAGTGGATATCAAACGA GGACGATCTTTGGAGTGGTCTTGGGGGACTACT SEQ ID NO: 1708 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1865 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM YQQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDASNENYADAVKG FTLTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDI RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR KR TIFGVVLGDYWGQGTLVTVSS SEQ ID NO: 138 SEQ ID NO: 295 iPS: 361851 6H1.009 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATAAATACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCAA AGGACACGGCTGTGTATTACTGTGCGCGAGATA GGGACCAAAGTGGATATCAAACGA GGACGATTTTTGGAGTGCTCTTGGGGGACTACT SEQ ID NO: 1709 GGGGCCAGGGAACCCTGGTCACCGTCTCCTCA SEQ ID NO: 1866 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM QQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTEFT HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG LTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDIK RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR R TIFGVLLGDYWGQGTLVTVSS SEQ ID NO: 139 SEQ ID NO: 296 iPS: 361855 2C2.005. NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG 015 GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGTAGCTCCAACATCGGAAGTAATACTG AAGGCTTCCGGATACACCTTCACCGGCTACTAT TAAACTGGTACCAGCAACTCCCAGGAACGGCCC ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATCTATACTAATAATCAGCGGC CTTGAGTGGATGGGATGGATCAACCCTAACAGT CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GGTGGCACAAACTATGCACAGAAGTTTCAGGGC GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG AGGGTCACCATGACCAGGGACACGTCCATCAGT CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT CAACATTCGATAGCAGCCTGAGTGGTCCGGTAT GACGACACGGCCGTGTATTACTGTGCGAGAGGG TCGGCGGAGGGACCAAGCTGACCGTCCTAGGT GGGGATTACGTTTGGGGGACTTATCGGCCTCAC SEQ ID NO: 1710 TACTACTACGGTATGGACGTCTGGGGCCAAGGG ACCACGGTCACCGTCTCCTCA SEQ ID NO: 1867 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNW QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY YQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ ASLAISGLQSEDEADYFCATFDSSLSGPVFGGGTK GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG LTVLG GDYVWGTYRPHYYYGMDVWGQGTTVTVSS SEQ ID NO: 140 SEQ ID NO: 297 iPS: 336067 5G12.006 NA GACATCCAGCTGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACTATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGACCATTAGCAGGTTTTTAA ACAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCTGGGAAAGCCCCTG ATACACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTATGTTGCATCCAGTTTGCAAAG CTGGAGTGGGTGGCAGTTATATGGTATGATGGA TGGGGTCCCATCAAGATTCAGTGGCAGTGGTTC AGTAATAAGTTCCATGCAGACTCCGTGAAGGGC TGGGACAGATTTCACTCTCACCATCAGCAGTCT CGATTCACCATCTCCAGAGACAATTCCAAGAAC GCAACCTGAAGATTTTGCAACTTACTACTGTCA ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC ACAGAGTTACAGTACCCTGATCAGTTTTGGCCA GAGGACTCGGCTATGTACTTCTGTGCGAGAGGA GGGGACCAAGCTGGAGATCACACGA AAAGTGGCTGGTATGCCTGAAGCTTTTGAAATC SEQ ID NO: 1711 TGGGGCCAAGGGACAAAGGTCACCGTCTCTTCA SEQ ID NO: 1868 AA DIQLTQSPSSLSASVGDRVTITCRASQTISRFLNWY QVQLVESGGGVVQPGRSLRLSCTASGFTFSSYGIH QQKPGKAPELLIYVASSLQSGVPSRFSGSGSGTDFT WVRQAPGKGLEWVAVIWYDGSNKFHADSVKGRF LTISSLQPEDFATYYCQQSYSTLISFGQGTKLEITR TISRDNSKNTLYLQMNSLRAEDSAMYFCARGKVA SEQ ID NO: 141 GMPEAFEIWGQGTKVTVSS SEQ ID NO: 298 iPS: 336169 17B11.002 NA CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGCAGCTCCAACATTGGAAATAATTATG AAGGCTTCTGGATACACCTTCACCAGTTATGAT TATCCTGGTATGAGCAGTTCCCAGGAACAGCCC ATCAACTGGGTGCGACAGGCCACTGGACAAGGG CCAAACTCCTCATTTATGACAATAATAAGCGAC CTTGAGTGGATGGGATGGATGAACCCTAACAGT CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GGTAACACAGGCTATGCACAGAAGTTCCAGGGC GTCTGGCACGTCAGCCACCCTGGGCATCACCGG AGAGTCACCATGACCAGGGACACCTCCATAAGC ACTCCAGACTGGGGACGAGGCCGATTATTACTG ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT CGGAACATGGGATAGCAGCCTGAGTGCTGTGGT CAGGACACGGCCGTGTATTACTGTGCGAGAGGG ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG GGTGATTACGTTTGGGGGAGTTATCGTCCCTACT T ACTACTACTACGGTATGGACGTCTGGGGCCAAG SEQ ID NO: 1712 GGACCACGGTCACCGTCTCCTCA SEQ ID NO: 1869 AA QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS QMQLVQSGAEVKKPGASVKVSCKASGYTFTSYDI WYEQFPGTAPKLLIYDNNKRPSGIPDRFSGSKSGTS NWVRQATGQGLEWMGWMNPNSGNTGYAQKFQ ATLGITGLQTGDEADYYCGTWDSSLSAVVFGGGT GRVTMTRDTSISTAYMELSSLRSQDTAVYYCARG KLTVLG GDYVWGSYRPYYYYYGMDVWGQGTTVTVSS SEQ ID NO: 142 SEQ ID NO: 299 iPS: 361127 5G12.006. NA GACATCCAGCTGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTG 001 CTGCATCTGTAGGAGACAGAGTCACTATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGACCATTAGCAGGTTTTTAA GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCTGGGAAAGCCCCTG ATACACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTATGTTGCATCCAGTTTGCAAAG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA TGGGGTCCCATCAAGATTCAGTGGCAGTGGTTC AGTAATAAGTTCCATGCAGACGCCGTGAAGGGC TGGGACAGATTTCACTCTCACCATCAGCAGTCT CGATTCACCATCTCCAGAGACAATTCCAAGAAC GCAACCTGAAGATTTTGCAACTTACTACTGTCA ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC ACAGAGTTACAGTACCCTGATCAGTTTTGGCCA GAGGACTCGGCTATGTACTTCTGTGCGAGAGGA GGGGACCAAGCTGGAGATCAAACGA AAAGTGGCTGGTATGCCTGAAGCTTTTGAAATC SEQ ID NO: 1713 TGGGGCCAAGGGACAAAGGTCACCGTCTCTTCA SEQ ID NO: 1870 AA DIQLTQSPSSLSASVGDRVTITCRASQTISRFLNWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGIH QQKPGKAPELLIYVASSLQSGVPSRFSGSGSGTDFT WVRQAPGKGLEWVAVIWYDASNKFHADAVKGR LTISSLQPEDFATYYCQQSYSTLISFGQGTKLEIKR FTISRDNSKNTLYLQMNSLRAEDSAMYFCARGKV SEQ ID NO: 143 AGMPEAFEIWGQGTKVTVSS SEQ ID NO: 300 iPS: 361136 5G12.006. NA GACATCCAGCTGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTG 002 CTGCATCTGTAGGAGACAGAGTCACTATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGACCATTAGCAGGTTTTTAA ACAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCTGGGAAAGCCCCTG ATACACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTATGTTGCATCCAGTTTGCAAAG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA TGGGGTCCCATCAAGATTCAGTGGCAGTGGTTC AGTAATAAGTTCCATGCAGACGCCGTGAAGGGC TGGGACAGATTTCACTCTCACCATCAGCAGTCT CGATTCACCATCTCCAGAGACAATTCCAAGAAC GCAACCTGAAGATTTTGCAACTTACTACTGTCA ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC ACAGAGTTACAGTACCCTGATCAGTTTTGGCCA GAGGACTCGGCTATGTACTTCTGTGCGAGAGGA GGGGACCAAGCTGGAGATCAAACGA AAAGTGGCTGGTATGCCTGAAGCTTTTGAAATC SEQ ID NO: 1714 TGGGGCCAAGGGACAAAGGTCACCGTCTCTTCA SEQ ID NO: 1871 AA DIQLTQSPSSLSASVGDRVTITCRASQTISRFLNWY QVQLVESGGGVVQPGRSLRLSCTASGFTFSSYGIH QQKPGKAPELLIYVASSLQSGVPSRFSGSGSGTDFT WVRQAPGKGLEWVAVIWYDASNKFHADAVKGR LTISSLQPEDFATYYCQQSYSTLISFGQGTKLEIKR FTISRDNSKNTLYLQMNSLRAEDSAMYFCARGKV SEQ ID NO: 144 AGMPEAFEIWGQGTKVTVSS SEQ ID NO: 301 iPS: 361140 5G12.006. NA GACATCCAGCTGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTG 003 CTGCATCTGTAGGAGACAGAGTCACTATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGACCATTAGCAGGTTTTTAA GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCTGGGAAAGCCCCTG ATACACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTATGTTGCATCCAGTTTGCAAAG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA TGGGGTCCCATCAAGATTCAGTGGCAGTGGTTC AGTAATAAGTTCCATGCAGACGCCGTGAAGGGC TGGGACAGATTTCACTCTCACCATCAGCAGTCT CGATTCACCATCTCCAGAGACAATTCCAAGAAC GCAACCTGAAGATTTTGCAACTTACTACTGTCA ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC ACAGAGTTACAGTACCCTGATCAGTTTTGGCCA GAGGACTCGGCTATGTACTTCTGTGCGAGAGGA GGGGACCAAGCTGGAGATCACACGA AAAGTGGCTGGTATGCCTGAAGCTTTTGAAATC SEQ ID NO: 1715 TGGGGCCAAGGGACAAAGGTCACCGTCTCTTCA SEQ ID NO: 1872 AA DIQLTQSPSSLSASVGDRVTITCRASQTISRFLNWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGIH QQKPGKAPELLIYVASSLQSGVPSRFSGSGSGTDFT WVRQAPGKGLEWVAVIWYDASNKFHADAVKGR LTISSLQPEDFATYYCQQSYSTLISFGQGTKLEITR FTISRDNSKNTLYLQMNSLRAEDSAMYFCARGKV SEQ ID NO: 145 AGMPEAFEIWGQGTKVTVSS SEQ ID NO: 302 iPS: 359919 5G12.006. NA GACATCCAGCTGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTG 004 CTGCATCTGTAGGAGACAGAGTCACTATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGACCATTAGCAGGTTTTTAA GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCTGGGAAAGCCCCTA ATACACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTATGTTGCATCCAGTTTGCAAAG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA TGGGGTCCCATCAAGATTCAGTGGCAGTGGTTC AGTAATAAGTTCCATGCAGACGCCGTGAAGGGC TGGGACAGATTTCACTCTCACCATCAGCAGTCT CGATTCACCATCTCCAGAGACAATTCCAAGAAC GCAACCTGAAGATTTTGCAACTTACTACTGTCA ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC ACAGAGTTACAGTACCCTGATCAGTTTTGGCCA GAGGACTCGGCTATGTACTTCTGTGCGAGAGGA GGGGACCAAGCTGGAGATCAAACGA AAAGTGGCTGGTATGCCTGAAGCTTTTGAAATC SEQ ID NO: 1716 TGGGGCCAAGGGACATTGGTCACCGTCTCTTCA SEQ ID NO: 1873 AA DIQLTQSPSSLSASVGDRVTITCRASQTISRFLNWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGIH QQKPGKAPKLLIYVASSLQSGVPSRFSGSGSGTDF WVRQAPGKGLEWVAVIWYDASNKFHADAVKGR TLTISSLQPEDFATYYCQQSYSTLISFGQGTKLEIK FTISRDNSKNTLYLQMNSLRAEDSAMYFCARGKV R AGMPEAFEIWGQGTLVTVSS SEQ ID NO: 146 SEQ ID NO: 303 iPS: 361144 5G12.006. NA GACATCCAGCTGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTG 005 CTGCATCTGTAGGAGACAGAGTCACTATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGACCATTAGCAGGTTTTTAA GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCTGGGAAAGCCCCTG ATACACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTATGTTGCATCCAGTTTGCAAAG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA TGGGGTCCCATCAAGATTCAGTGGCAGTGGTTC AGTAATAAGTTCCATGCAGACTCCGTGAAGGGC TGGGACAGATTTCACTCTCACCATCAGCAGTCT CGATTCACCATCTCCAGAGACAATTCCAAGAAC GCAACCTGAAGATTTTGCAACTTACTACTGTCA ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC ACAGAGTTACAGTACCCTGATCAGTTTTGGCCA GAGGACTCGGCTATGTACTTCTGTGCGAGAGGA GGGGACCAAGCTGGAGATCAAACGA AAAGTGGCTGGTATGCCTGAAGCTTTTGAAATC SEQ ID NO: 1717 TGGGGCCAAGGGACAAAGGTCACCGTCTCTTCA SEQ ID NO: 1874 AA DIQLTQSPSSLSASVGDRVTITCRASQTISRFLNWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGIH QQKPGKAPELLIYVASSLQSGVPSRFSGSGSGTDFT WVRQAPGKGLEWVAVIWYDASNKFHADSVKGRF LTISSLQPEDFATYYCQQSYSTLISFGQGTKLEIKR TISRDNSKNTLYLQMNSLRAEDSAMYFCARGKVA SEQ ID NO: 147 GMPEAFEIWGQGTKVTVSS SEQ ID NO: 304 iPS: 361151 5G12.006. NA GACATCCAGCTGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTG 006 CTGCATCTGTAGGAGACAGAGTCACTATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGACCATTAGCAGGTTTTTAA GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCTGGGAAAGCCCCTG ATACACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTATGTTGCATCCAGTTTGCAAAG CTGGAGTGGGTGGCAGTTATATGGTATGATGGA TGGGGTCCCATCAAGATTCAGTGGCAGTGGTTC AGTAATAAGTTCCATGCAGACGCCGTGAAGGGC TGGGACAGATTTCACTCTCACCATCAGCAGTCT CGATTCACCATCTCCAGAGACAATTCCAAGAAC GCAACCTGAAGATTTTGCAACTTACTACTGTCA ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC ACAGAGTTACAGTACCCTGATCAGTTTTGGCCA GAGGACTCGGCTATGTACTTCTGTGCGAGAGGA GGGGACCAAGCTGGAGATCAAACGA AAAGTGGCTGGTATGCCTGAAGCTTTTGAAATC SEQ ID NO: 1718 TGGGGCCAAGGGACAAAGGTCACCGTCTCTTCA SEQ ID NO: 1875 AA DIQLTQSPSSLSASVGDRVTITCRASQTISRFLNWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGIH QQKPGKAPELLIYVASSLQSGVPSRFSGSGSGTDFT WVRQAPGKGLEWVAVIWYDGSNKFHADAVKGR LTISSLQPEDFATYYCQQSYSTLISFGQGTKLEIKR FTISRDNSKNTLYLQMNSLRAEDSAMYFCARGKV SEQ ID NO: 148 AGMPEAFEIWGQGTKVTVSS SEQ ID NO: 305 iPS: 361491 17B11. NA CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG 002.001 CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGCAGCTCCAACATTGGAAATAATTATG AAGGCTTCTGGATACACCTTCACCAGTTATGAT TATCCTGGTATCAGCAGCTCCCAGGAACAGCCC ATCAACTGGGTGCGACAGGCCACTGGACAAGGG CCAAACTCCTCATTTATGACAATAATAAGCGAC CTTGAGTGGATGGGATGGATGAACCCTAACAGT CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GGTGGCACAGGCTATGCACAGAAGTTCCAGGGC GTCTGGCACGTCAGCCACCCTGGGCATCACCGG AGAGTCACCATGACCAGGGACACCTCCATAAGC ACTCCAGACTGGGGACGAGGCCGATTATTACTG ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT CGGAACATGGGATAGCAGCCTGAGTGCTGTGGT CAGGACACGGCCGTGTATTACTGTGCGAGAGGG ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG GGTGATTACGTTTGGGGGAGTTATCGTCCCTACT T ACTACTACTACGGTATGGACGTCTGGGGCCAAG SEQ ID NO: 1719 GGACCACGGTCACCGTCTCCTCA SEQ ID NO: 1876 AA QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS QMQLVQSGAEVKKPGASVKVSCKASGYTFTSYDI WYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGT NWVRQATGQGLEWMGWMNPNSGGTGYAQKFQ SATLGITGLQTGDEADYYCGTWDSSLSAVVFGGG GRVTMTRDTSISTAYMELSSLRSQDTAVYYCARG TKLTVLG GDYVWGSYRPYYYYYGMDVWGQGTTVTVSS SEQ ID NO: 149 SEQ ID NO: 306 iPS: 361499 17B11. NA CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG 002.002 CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGCAGCTCCAACATTGGAAATAATTATG AAGGCTTCTGGATACACCTTCACCAGTTATGAT TATCCTGGTATCAGCAGCTCCCAGGAACAGCCC ATCAACTGGGTGCGACAGGCCACTGGACAAGGG CCAAACTCCTCATTTATGACAATAATAAGCGAC CTTGAGTGGATGGGATGGATGAACCCTAACAGT CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GGTAACACAGGCTATGCACAGAAGTTCCAGGGC GTCTGGCACGTCAGCCACCCTGGGCATCACCGG AGAGTCACCATGACCAGGGACACCTCCATAAGC ACTCCAGACTGGGGACGAGGCCGATTATTACTG ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT CGGAACATGGGATAGCAGCCTGAGTGCTGTGGT CAGGACACGGCCGTGTATTACTGTGCGAGAGGG ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG GGTGATTACGTTTGGGGGAGTTATCGTCCCTACT T ACTACTACTACGGTATGGACGTCTGGGGCCAAG SEQ ID NO: 1720 GGACCACGGTCACCGTCTCCTCA SEQ ID NO: 1877 AA QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS QMQLVQSGAEVKKPGASVKVSCKASGYTFTSYDI WYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGT NWVRQATGQGLEWMGWMNPNSGNTGYAQKFQ SATLGITGLQTGDEADYYCGTWDSSLSAVVFGGG GRVTMTRDTSISTAYMELSSLRSQDTAVYYCARG TKLTVLG GDYVWGSYRPYYYYYGMDVWGQGTTVTVSS SEQ ID NO: 150 SEQ ID NO: 307 iPS: 361503 17B11. NA CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG 002.003 CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGCAGCTCCAACATTGGAAATAATTATG AAGGCTTCTGGATACACCTTCACCAGTTATGAT TATCCTGGTATGAGCAGTTCCCAGGAACAGCCC ATCAACTGGGTGCGACAGGCCACTGGACAAGGG CCAAACTCCTCATTTATGACAATAATAAGCGAC CTTGAGTGGATGGGATGGATGAACCCTAACAGT CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GGTGGCACAGGCTATGCACAGAAGTTCCAGGGC GTCTGGCACGTCAGCCACCCTGGGCATCACCGG AGAGTCACCATGACCAGGGACACCTCCATAAGC ACTCCAGACTGGGGACGAGGCCGATTATTACTG ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT CGGAACATGGGATAGCAGCCTGAGTGCTGTGGT CAGGACACGGCCGTGTATTACTGTGCGAGAGGG ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG GGTGATTACGTTTGGGGGAGTTATCGTCCCTACT T ACTACTACTACGGTATGGACGTCTGGGGCCAAG SEQ ID NO: 1721 GGACCACGGTCACCGTCTCCTCA SEQ ID NO: 1878 AA QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS QMQLVQSGAEVKKPGASVKVSCKASGYTFTSYDI WYEQFPGTAPKLLIYDNNKRPSGIPDRFSGSKSGTS NWVRQATGQGLEWMGWMNPNSGGTGYAQKFQ ATLGITGLQTGDEADYYCGTWDSSLSAVVFGGGT GRVTMTRDTSISTAYMELSSLRSQDTAVYYCARG KLTVLG GDYVWGSYRPYYYYYGMDVWGQGTTVTVSS SEQ ID NO: 151 SEQ ID NO: 308 iPS: 361507 17B11. NA CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG 002.004 CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGCAGCTCCAACATTGGAAATAATTATG AAGGCTTCTGGATACACCTTCACCAGTTATGAT TATCCTGGTATCAGCAGCTCCCAGGAACAGCCC ATCAACTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATTTATGACAATAATAAGCGAC CTTGAGTGGATGGGATGGATGAACCCTAACAGT CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GGTGGCACAGGCTATGCACAGAAGTTCCAGGGC GTCTGGCACGTCAGCCACCCTGGCCATCACCGG AGAGTCACCATGACCAGGGACACCTCCATAAGC ACTCCAGACTGGGGACGAGGCCGATTATTACTG ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT CGGAACATTCGAAAGCAGCCTGAGTGCTGTGGT GACGACACGGCCGTGTATTACTGTGCGAGAGGG ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG GGTGATTACGTTTGGGGGAGTTATCGTCCCTACT T ACTACTACTACGGTATGGACGTCTGGGGCCAAG SEQ ID NO: 1722 GGACCACGGTCACCGTCTCCTCA SEQ ID NO: 1879 AA QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS QMQLVQSGAEVKKPGASVKVSCKASGYTFTSYDI WYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGT NWVRQAPGQGLEWMGWMNPNSGGTGYAQKFQ SATLAITGLQTGDEADYYCGTFESSLSAVVFGGGT GRVTMTRDTSISTAYMELSSLRSDDTAVYYCARG KLTVLG GDYVWGSYRPYYYYYGMDVWGQGTTVTVSS SEQ ID NO: 152 SEQ ID NO: 309 iPS: 361514 17B11. NA CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG 002.005 CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGCAGCTCCAACATTGGAAATAATTATG AAGGCTTCTGGATACACCTTCACCAGTTATGAT TATCCTGGTATCAGCAGCTCCCAGGAACAGCCC ATCAACTGGGTGCGACAGGCCACTGGACAAGGG CCAAACTCCTCATTTATGACAATAATAAGCGAC CTTGAGTGGATGGGATGGATGAACCCTAACAGT CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GGTGGCACAGGCTATGCACAGAAGTTCCAGGGC GTCTGGCACGTCAGCCACCCTGGCCATCACCGG AGAGTCACCATGACCAGGGACACCTCCATAAGC ACTCCAGACTGGGGACGAGGCCGATTATTACTG ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT CGGAACATGGGATAGCAGCCTGAGTGCTGTGGT CAGGACACGGCCGTGTATTACTGTGCGAGAGGG ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG GGTGATTACGTTTGGGGGAGTTATCGTCCCTACT T ACTACTACTACGGTATGGACGTCTGGGGCCAAG SEQ ID NO: 1723 GGACCACGGTCACCGTCTCCTCA SEQ ID NO: 1880 AA QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS QMQLVQSGAEVKKPGASVKVSCKASGYTFTSYDI WYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGT NWVRQATGQGLEWMGWMNPNSGGTGYAQKFQ SATLAITGLQTGDEADYYCGTWDSSLSAVVFGGG GRVTMTRDTSISTAYMELSSLRSQDTAVYYCARG TKLTVLG GDYVWGSYRPYYYYYGMDVWGQGTTVTVSS SEQ ID NO: 153 SEQ ID NO: 310 iPS: 360582 17B11. NA CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG 002.006 CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGCAGCTCCAACATTGGAAATAATTATG AAGGCTTCTGGATACACCTTCACCAGTTATGAT TATCCTGGTATCAGCAGCTCCCAGGAACAGCCC ATCAACTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATTTATGACAATAATAAGCGAC CTTGAGTGGATGGGATGGATGAACCCTAACAGT CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GGTAACACAGGCTATGCACAGAAGTTCCAGGGC GTCTGGCACGTCAGCCACCCTGGCCATCACCGG AGAGTCACCATGACCAGGGACACCTCCATAAGC ACTCCAGACTGGGGACGAGGCCGATTATTACTG ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT CGGAACATGGGATAGCAGCCTGAGTGCTGTGGT GACGACACGGCCGTGTATTACTGTGCGAGAGGG ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG GGTGATTACGTTTGGGGGAGTTATCGTCCCTACT T ACTACTACTACGGTATGGACGTCTGGGGCCAAG SEQ ID NO: 1724 GGACCACGGTCACCGTCTCCTCA SEQ ID NO: 1881 AA QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS QMQLVQSGAEVKKPGASVKVSCKASGYTFTSYDI WYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGT NWVRQAPGQGLEWMGWMNPNSGNTGYAQKFQ SATLAITGLQTGDEADYYCGTWDSSLSAVVFGGG GRVTMTRDTSISTAYMELSSLRSDDTAVYYCARG TKLTVLG GDYVWGSYRPYYYYYGMDVWGQGTTVTVSS SEQ ID NO: 154 SEQ ID NO: 311 iPS: 361518 17B11. NA CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG 002.007 CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGCAGCTCCAACATTGGAAATAATTATG AAGGCTTCTGGATACACCTTCACCAGTTATGAT TATCCTGGTATCAGCAGCTCCCAGGAACAGCCC ATCAACTGGGTGCGACAGGCCACTGGACAAGGG CCAAACTCCTCATTTATGACAATAATAAGCGAC CTTGAGTGGATGGGATGGATGAACCCTAACAGT CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GGTGGCACAGGCTATGCACAGAAGTTCCAGGGC GTCTGGCACGTCAGCCACCCTGGGCATCACCGG AGAGTCACCATGACCAGGGACACCTCCATAAGC ACTCCAGACTGGGGACGAGGCCGATTATTACTG ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT CGGAACATGGGATAGCAGCCTGAGTGCTGTGGT CAGGACACGGCCGTGTATTACTGTGCGAGAGGG ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG GGTGATTACGTTTTCGGGAGTTATCGTCCCTACT T ACTACTACTACGGTATGGACGTCTGGGGCCAAG SEQ ID NO: 1725 GGACCACGGTCACCGTCTCCTCA SEQ ID NO: 1882 AA QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS QMQLVQSGAEVKKPGASVKVSCKASGYTFTSYDI WYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGT NWVRQATGQGLEWMGWMNPNSGGTGYAQKFQ SATLGITGLQTGDEADYYCGTWDSSLSAVVFGGG GRVTMTRDTSISTAYMELSSLRSQDTAVYYCARG TKLTVLG GDYVFGSYRPYYYYYGMDVWGQGTTVTVSS SEQ ID NO: 155 SEQ ID NO: 312 iPS: 360570 17B11. NA CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG 002.008 CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGCAGCTCCAACATTGGAAATAATTATG AAGGCTTCTGGATACACCTTCACCAGTTATGAT TATCCTGGTATCAGCAGCTCCCAGGAACAGCCC ATCAACTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATTTATGACAATAATAAGCGAC CTTGAGTGGATGGGATGGATGAACCCTAACAGT CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GGTGGCACAGGCTATGCACAGAAGTTCCAGGGC GTCTGGCACGTCAGCCACCCTGGCCATCACCGG AGAGTCACCATGACCAGGGACACCTCCATAAGC ACTCCAGACTGGGGACGAGGCCGATTATTACTG ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT CGGAACATTCGAAAGCAGCCTGAGTGCTGTGGT GACGACACGGCCGTGTATTACTGTGCGAGAGGG ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG GGTGATTACGTTTTCGGGAGTTATCGTCCCTACT T ACTACTACTACGGTATGGACGTCTGGGGCCAAG SEQ ID NO: 1726 GGACCACGGTCACCGTCTCCTCA SEQ ID NO: 1883 AA QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS QMQLVQSGAEVKKPGASVKVSCKASGYTFTSYDI WYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGT NWVRQAPGQGLEWMGWMNPNSGGTGYAQKFQ SATLAITGLQTGDEADYYCGTFESSLSAVVFGGGT GRVTMTRDTSISTAYMELSSLRSDDTAVYYCARG KLTVLG GDYVFGSYRPYYYYYGMDVWGQGTTVTVSS SEQ ID NO: 156 SEQ ID NO: 313 iPS: 362051 5G12. NA GACATCCAGCTGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTG 005.001 CTGCATCTGTAGGAGACAGAGTCACTATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGACCATTAGCAGGTTTTTAA GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCTGGGAAAGCCCCTA ATACACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTATGTTGCATCCAGTTTGCAAAG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA TGGGGTCCCATCAAGATTCAGTGGCAGTGGTTC AGTAATAAGTTCCATGCAGACGCCGTGAAGGGC TGGGACAGATTTCACTCTCACCATCAGCAGTCT CGATTCACCATCTCCAGAGACAATTCCAAGAAC GCAACCTGAAGATTTTGCAACTTACTACTGTCA ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC ACAGAGTTACAGTACCCTGCTCAGTTTTGGCCA GAGGACTCGGCTATGTACTTCTGTGCGAGAGGA GGGGACCAAGCTGGAGATCAAACGA AAAGTGGCTGGTATGCCTGAAGCTTTTGAAATC SEQ ID NO: 1727 TGGGGCCAAGGGACATTGGTCACCGTCTCTTCA SEQ ID NO: 1884 AA DIQLTQSPSSLSASVGDRVTITCRASQTISRFLNWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGIH QQKPGKAPKLLIYVASSLQSGVPSRFSGSGSGTDF WVRQAPGKGLEWVAVIWYDASNKFHADAVKGR TLTISSLQPEDFATYYCQQSYSTLLSFGQGTKLEIK FTISRDNSKNTLYLQMNSLRAEDSAMYFCARGKV R AGMPEAFEIWGQGTLVTVSS SEQ ID NO: 157 SEQ ID NO: 314 Table 4. Exemplary CDRL1, CDRL2, CDRL3, CDRH1, CDRH2, and CDRH3 Nucleic Acid (“NA”) and Amino Acid (“AA”) Sequences

TABLE 4A Exemplary CDRL1, CDRL2, and CDRL3 Nucleic Acid (″NA″) and Amino Acid (″AA″) Sequences iPS# Ab Type CDRL1 CDRL2 CDRL3 iPS:336175 2C2.005 NA TCTGGAAGTAGCTCCAACATCG ACTAATAATCAGCGGCCCTCA GCAACATTCGATGACAGCCTG GAAGTAATACTGTAAAC SEQ ID NO: 2356 AATGGTCCGGTA SEQ ID NO: 2199 SEQ ID NO: 2513 AA SGSSSNIGSNTVN TNNQRPS ATFDDSLNGPV SEQ ID NO: 629 SEQ ID NO: 786 SEQ ID NO: 943 iPS:335914 4B1 NA CGGGCAAGTCAGGACATTAGAG GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCT ATTATTTAGGC SEQ ID NO: 2357 TCACT SEQ ID NO: 2200 SEQ ID NO: 2514 AA RASQDIRDYLG GASSLQS LQHNNYPFT SEQ ID NO: 630 SEQ ID NO: 787 SEQ ID NO: 944 iPS:335938 6H1 NA CGGGCAAGTCAGGACATTAGAG GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCT ATTATTTAGGC SEQ ID NO: 2358 TCACT SEQ ID NO: 2201 SEQ ID NO: 2515 AA RASQDIRDYLG GASSLQS LQHNNYPFT SEQ ID NO: 631 SEQ ID NO: 788 SEQ ID NO: 945 iPS:335941 2F11 NA CAGGCGAGTCAGGACATTAGCA GATGCATCCAATTTGGAAACA CAACAGTATGATATTCTCCTCA ACTATTTAAAT SEQ ID NO: 2359 CT SEQ ID NO: 2202 SEQ ID NO: 2516 AA QASQDISNYLN DASNLET QQYDILLT SEQ ID NO: 632 SEQ ID NO: 789 SEQ ID NO: 946 iPS:335970 5C2 NA AAGTCCAGCCAGAGTGTTTTAT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2360 GGACG CATAGCT SEQ ID NO: 2517 SEQ ID NO: 2203 AA KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT SEQ ID NO: 633 SEQ ID NO: 790 SEQ ID NO: 947 iPS:335978 13H12 NA AAGTCCAGCCAGAGTGTTTTAT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2361 GGACG CATAGCT SEQ ID NO: 2518 SEQ ID NO: 2204 AA KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT SEQ ID NO: 634 SEQ ID NO: 791 SEQ ID NO: 948 iPS:335986 11C1 NA AAGTCCAGCCAGAGTGTTTTAT TGGACTTCTACCCGAGATTCC CAGCAATATTATCGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2362 GGACG CTTAGCT SEQ ID NO: 2519 SEQ ID NO: 2205 AA KSSQSVLSSSNNKNYLA WTSTRDS QQYYRTPWT SEQ ID NO: 635 SEQ ID NO: 792 SEQ ID NO: 949 iPS:335994 12H11 NA AAGTCCAGCCAGAGTGTTTTAT TGGACTTCTACCCGAGATTCC CAGCAATATTATCGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2363 GGACG CTTAGCT SEQ ID NO: 2520 SEQ ID NO: 2206 AA KSSQSVLSSSNNKNYLA WTSTRDS QQYYRTPWT SEQ ID NO: 636 SEQ ID NO: 793 SEQ ID NO: 950 iPS:336024 18E3 NA AGGGCCAGTCAGAGTATTAGTT GGTGCATCCAGCAGGGCCACT CAGCAGTATGGTAGTTCACCGC ACAGTTACTTAGCC SEQ ID NO: 2364 TCACT SEQ ID NO: 2207 SEQ ID NO: 2521 AA RASQSISYSYLA GASSRAT QQYGSSPLT SEQ ID NO: 637 SEQ ID NO: 794 SEQ ID NO: 951 iPS:336041 2G10_LC1 NA AGGGCCAGTCAGAGTGTTAGCA GGTGCAGCCACCAGGGCCACT CAGCAGTATAATAACTGGCCTC GCAACTTAGCC SEQ ID NO: 2365 TCACT SEQ ID NO: 2208 SEQ ID NO: 2522 AA RASQSVSSNLA GAATRAT QQYNNWPLT SEQ ID NO: 638 SEQ ID NO: 795 SEQ ID NO: 952 iPS:336077 4H9.004 NA CGGGCAAGTCAGGGCATTAGAA GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAGTTACCCAT ATGAGTTAGGC SEQ ID NO: 2366 TCACT SEQ NO: 2209 SEQ ID NO: 2523 AA RASQGIRNELG GASSLQS LQHNSYPFT SEQ ID NO: 639 SEQ ID NO: 796 SEQ ID NO: 953 iPS:336088 6A5.044 NA CAGGCGAGTCAGGACATTACCA GATGCTTCCAATTTGGAGCCA CAACAGTATGATGATCTATTCA ACTATTTAAAT SEQ ID NO: 2367 CT SEQ ID NO: 2210 SEQ ID NO: 2524 AA QDITNYLN DASNLEP QQYDDLFT SEQ ID NO: 640 SEQ ID NO: 797 SEQ ID NO: 954 iPS:336099 17H11.004 NA CGGGCGAGTCAGGGTCTTATCA GCTGCATCCAGTTTGCAAAGT CAACAGACTAACAGTTTCCCTC TCTGGTTAGCC SEQ ID NO: 2368 CGACG SEQ ID NO: 2211 SEQ ID NO: 2525 AA RASQGLIIWLA AASSLQS QQTNSFPPT SEQ ID NO: 641 SEQ ID NO: 798 SEQ ID NO: 955 iPS:359621 17H11.004.001 NA CGGGCGAGTCAGGGTCTTATCA GCTGCATCCAGTTTGCAAAGT CAACAGACTAACAGTTTCCCTC TCTGGTTAGCC SEQ ID NO: 2369 CGACG SEQ ID NO: 2212 SEQ ID NO: 2526 AA RASQGLIIWLA AASSLQS QQTNSFPPT SEQ ID NO: 642 SEQ ID NO: 799 SEQ ID NO: 956 iPS:359781 4H9.004.001 NA CGGGCAAGTCAGGGCATTAGAA GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAGTTACCCAT ATGAGTTAGGC SEQ ID NO: 2370 TCACT SEQ ID NO: 2213 SEQ ID NO: 2527 AA RASQGIRNELG GASSLQS LQHNSYPFT SEQ ID NO: 643 SEQ ID NO: 800 SEQ ID NO: 957 iPS:360929 4H9.004.002 NA CGGGCAAGTCAGGGCATTAGAA GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAGTTACCCAT ATGAGTTAGGC SEQ ID NO: 2371 TCACT SEQ ID NO: 2214 SEQ ID NO: 2528 AA RASQGIRNELG GASSLQS LQHNSYPFT SEQ ID NO: 644 SEQ ID NO: 801 SEQ ID NO: 958 iPS:360936 4H9.004.003 NA CGGGCAAGTCAGGGCATTAGAA GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAGTTACCCAT ATGAGTTAGGC SEQ ID NO: 2372 TCACT SEQ ID NO: 2215 SEQ ID NO: 2529 AA RASQGIRNELG GASSLQS LQHNSYPFT SEQ ID NO: 645 SEQ ID NO: 802 SEQ ID NO: 959 iPS:360943 4H9.004.004 NA CGGGCAAGTCAGGGCATTAGAA GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAGTTACCCAT ATGAGTTAGGC SEQ ID NO: 2373 TCACT SEQ ID NO: 2216 SEQ ID NO: 2530 AA RASQGIRNELG GASSLQS LQHNSYPFT SEQ ID NO: 646 SEQ ID NO: 803 SEQ ID NO: 960 iPS:360949 4H9.004.005 NA CGGGCAAGTCAGGGCATTAGAA GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAGTTACCCAT ATGAGTTAGGC SEQ ID NO: 2374 TCACT SEQ ID NO: 2217 SEQ ID NO: 2531 AA RASQGIRNELG GASSLQS LQHNSYPFT SEQ ID NO: 647 SEQ ID NO: 804 SEQ ID NO: 961 iPS:359761 4H9.004.006 NA CGGGCAAGTCAGGGCATTAGAA GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAGTTACCCAT ATGAGTTAGGC SEQ ID NO: 2375 TCACT SEQ ID NO: 2218 SEQ ID NO: 2532 AA RASQGIRNELG GASSLQS LQHNSYPFT SEQ ID NO: 648 SEQ ID NO: 805 SEQ ID NO: 962 iPS:360955 4B1.010 NA CGGGCAAGTCAGGACATTAGAG GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCT ATTATTTAGGC SEQ ID NO: 2376 TCACT SEQ ID NO: 2219 SEQ ID NO: 2533 AA ASQDIRDYLG GASSLQS LQHNNYPFT SEQ ID NO: 649 SEQ ID NO: 806 SEQ ID NO: 963 iPS:360962 4B1.011 NA CGGGCAAGTCAGGACATTAGAG GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCT ATTATTTAGGC SEQ ID NO: 2377 TCACT SEQ ID NO: 2220 SEQ ID NO: 2534 AA RASQDIRDYLG GASSLQS LQHNNYPFT SEQ ID NO: 650 SEQ ID NO: 807 SEQ ID NO: 964 iPS:360968 4B1.012 NA CGGGCAAGTCAGGACATTAGAG GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCT ATTATTTAGGC SEQ ID NO: 2378 TCACT SEQ ID NO: 2221 SEQ ID NO: 2535 AA RASQDIRDYLG GASSLQS LQHNNYPFT SEQ ID NO: 651 SEQ ID NO: 808 SEQ ID NO: 965 iPS:360974 4B1.013 NA CGGGCAAGTCAGGACATTAGAG GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCT ATTATTTAGGC SEQ ID NO: 2379 TCACT SEQ ID NO: 2222 SEQ ID NO: 2536 AA RASQDIRDYLG GASSLQS LQHNNYPFT SEQ ID NO: 652 SEQ ID NO: 809 SEQ ID NO: 966 iPS:360978 4B1.014 NA CGGGCAAGTCAGGACATTAGAG GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCT ATTATTTAGGC SEQ ID NO: 2380 TCACT SEQ ID NO: 2223 SEQ ID NO: 2537 AA RASQDIRDYLG GASSLQS LQHNNYPFT SEQ ID NO: 653 SEQ ID NO: 810 SEQ ID NO: 967 iPS:359785 4B1.015 NA CGGGCAAGTCAGGACATTAGAG GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCT ATTATTTAGGC SEQ ID NO: 2381 TCACT SEQ ID NO: 2224 SEQ ID NO: 2538 AA RASQDIRDYLG GASSLQS LQHNNYPFT SEQ ID NO: 654 SEQ ID NO: 811 SEQ ID NO: 968 iPS:360982 4B1.016 NA CGGGCAAGTCAGGACATTAGAG GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCT ATTATTTAGGC SEQ ID NO: 2382 TCACT SEQ ID NO: 2225 SEQ ID NO: 2539 AA RASQDIRDYLG GASSLQS LQHNNYPFT SEQ ID NO: 655 SEQ ID NO: 812 SEQ ID NO: 969 iPS:335922 18F2 NA CGGGCAAGTCAGGACCTTAGAA GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCT ATTATTTAGGC SEQ ID NO: 2383 TCACT SEQ ID NO: 2226 SEQ ID NO: 2540 AA RASQDLRNYLG GASSLQS LQHNNYPFT SEQ ID NO: 656 SEQ ID NO: 813 SEQ ID NO: 970 iPS:360986 18F2.002 NA CGGGCAAGTCAGGACCTTAGAA GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCT ATTATTTAGGC SEQ ID NO: 2384 TCACT SEQ ID NO: 2227 SEQ ID NO: 2541 AA RASQDLRNYLG GASSLQS LQHNNYPFT SEQ ID NO: 657 SEQ ID NO: 814 SEQ ID NO: 971 iPS:360995 18F2.003 NA CGGGCAAGTCAGGACCTTAGAA GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCT ATTATTTAGGC SEQ ID NO: 2385 TCACT SEQ ID NO: 2228 SEQ ID NO: 2542 AA RASQDLRNYLG GASSLQS LQHNNYPFT SEQ ID NO: 658 SEQ ID NO: 815 SEQ ID NO: 972 iPS:360999 18F2.004 NA CGGGCAAGTCAGGACCTTAGAA GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCT ATTATTTAGGC SEQ ID NO: 2386 TCACT SEQ ID NO: 2229 SEQ ID NO: 2543 AA RASQDLRNYLG GASSLQS LQHNNYPFT SEQ ID NO: 659 SEQ ID NO: 816 SEQ ID NO: 973 iPS:361005 18F2.005 NA CGGGCAAGTCAGGACCTTAGAA GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCT ATTATTTAGGC SEQ ID NO: 2387 TCACT SEQ ID NO: 2230 SEQ ID NO: 2544 AA RASQDLRNYLG GASSLQS LQHNNYPFT SEQ ID NO: 660 SEQ ID NO: 817 SEQ ID NO: 974 iPS:361009 18F2.006 NA CGGGCAAGTCAGGACCTTAGAA GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCT ATTATTTAGGC SEQ ID NO: 2388 TCACT SEQ ID NO: 2231 SEQ ID NO: 2545 AA RASQDLRNYLG GASSLQS LQHNNYPFT SEQ ID NO: 661 SEQ ID NO: 818 SEQ ID NO: 975 iPS:361013 18F2.007 NA CGGGCAAGTCAGGACCTTAGAA GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCT ATTATTTAGGC SEQ ID NO: 2389 TCACT SEQ ID NO: 2232 SEQ ID NO: 2546 AA RASQDLRNYLG GASSLQS LQHNNYPFT SEQ ID NO: 662 SEQ ID NO: 819 SEQ ID NO: 976 iPS:361017 18F2.008 NA CGGGCAAGTCAGGACCTTAGAA GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCT ATTATTTAGGC SEQ ID NO: 2390 TCACT SEQ ID NO: 2233 SEQ ID NO: 2547 AA RASQDLRNYLG GASSLQS LQHNNYPFT SEQ ID NO: 663 SEQ ID NO: 820 SEQ ID NO: 977 iPS:361021 18F2.009 NA CGGGCAAGTCAGGACCTTAGAA GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCT ATTATTTAGGC SEQ ID NO: 2391 TCACT SEQ ID NO: 2234 SEQ ID NO: 2548 AA RASQDLRNYLG GASSLQS LQHNNYPFT SEQ ID NO: 664 SEQ ID NO: 821 SEQ ID NO: 978 iPS:361028 18F2.010 NA CGGGCAAGTCAGGACCTTAGAA GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCT ATTATTTAGGC SEQ ID NO: 2392 TCACT SEQ ID NO: 2235 SEQ ID NO: 2549 AA RASQDLRNYLG GASSLQS LQHNNYPFT SEQ ID NO: 665 SEQ ID NO: 822 SEQ ID NO: 979 iPS:360535 18F2.011 NA CGGGCAAGTCAGGACCTTAGAA GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCT ATTATTTAGGC SEQ ID NO: 2393 TCACT SEQ ID NO: 2236 SEQ ID NO: 2550 AA RASQDLRNYLG GASSLQS LQHNNYPFT SEQ ID NO: 666 SEQ ID NO: 823 SEQ ID NO: 980 iPS:361035 18F2.012 NA CGGGCAAGTCAGGACCTTAGAA GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCT ATTATTTAGGC SEQ ID NO: 2394 TCACT SEQ ID NO: 2237 SEQ ID NO: 2551 AA RASQDLRNYLG GASSLQS LQHNNYPFT SEQ ID NO: 667 SEQ ID NO: 824 SEQ ID NO: 981 iPS:359940 2F11.002 NA CAGGCGAGTCAGGACATTAGCA GATGCATCCAATTTGGAAACA CAACAGTATGATATTCTCCTCA ACTATTTAAAT SEQ ID NO: 2395 CT SEQ ID NO: 2238 SEQ ID NO: 2552 AA QASQDISNYLN DASNLET QQYDILLT SEQ ID NO: 668 SEQ ID NO: 825 SEQ ID NO: 982 iPS:361039 2F11.003 NA CAGGCGAGTCAGGACATTAGCA GATGCATCCAATTTGGAAACA CAACAGTATGATATTCTCCTCA ACTATTTAAAT SEQ ID NO: 2396 CT SEQ ID NO: 2239 SEQ ID NO: 2553 AA QASQDISNYLN DASNLET QQYDILLT SEQ ID NO: 669 SEQ ID NO: 826 SEQ ID NO: 983 iPS:361043 2F11.004 NA CAGGCGAGTCAGGACATTAGCA GATGCATCCAATTTGGAAACA CAACAGTATGATATTCTCCTCA ACTATTTAAAT SEQ ID NO: 2397 CT SEQ ID NO: 2240 SEQ ID NO: 2554 AA QASQDISNYLN DASNLET QQYDILLT SEQ ID NO: 670 SEQ ID NO: 827 SEQ ID NO: 984 iPS:361049 2F11.005 NA CAGGCGAGTCAGGACATTAGCA GATGCATCCAATTTGGAAACA CAACAGTATGATATTCTCCTCA ACTATTTAAAT SEQ ID NO: 2398 CT SEQ ID NO: 2241 SEQ ID NO: 2555 AA QASQDISNYLN DASNLET QQYDILLT SEQ ID NO: 671 SEQ ID NO: 828 SEQ ID NO: 985 iPS:361055 2F11.006 NA CAGGCGAGTCAGGACATTAGCA GATGCATCCAATTTGGAAACA CAACAGTATGATATTCTCCTCA ACTATTTAAAT SEQ ID NO: 2399 CT SEQ ID NO: 2242 SEQ ID NO: 2556 AA QASQDISNYLN DASNLET QQYDILLT SEQ ID NO: 672 SEQ ID NO: 829 SEQ ID NO: 986 iPS:361059 2F11.007 NA CAGGCGAGTCAGGACATTAGCA GATGCATCCAATTTGGAAACA CAACAGTATGATATTCTCCTCA ACTATTTAAAT SEQ ID NO: 2400 CT SEQ ID NO: 2243 SEQ ID NO: 2557 AA QASQDISNYLN DASNLET QQYDILLT SEQ ID NO: 673 SEQ ID NO: 830 SEQ ID NO: 987 iPS:361063 2F11.008 NA CAGGCGAGTCAGGACATTAGCA GATGCATCCAATTTGGAAACA CAACAGTATGATATTCTCCTCA ACTATTTAAAT SEQ ID NO: 2401 CT SEQ ID NO: 2244 SEQ ID NO: 2558 AA QASQDISNYLN DASNLET QQYDILLT SEQ ID NO: 674 SEQ ID NO: 831 SEQ ID NO: 988 iPS:359949 2F11.009 NA CAGGCGAGTCAGGACATTAGCA GATGCATCCAATTTGGAAACA CAACAGTATGATATTCTCCTCA ACTATTTAAAT SEQ ID NO: 2402 CT SEQ ID NO: 2245 SEQ ID NO: 2559 AA QASQDISNYLN DASNLET QQYDILLT SEQ ID NO: 675 SEQ ID NO: 832 SEQ ID NO: 989 iPS:359956 2F11.010 NA CAGGCGAGTCAGGACATTAGCA GATGCATCCAATTTGGAAACA CAACAGTATGATATTCTCCTCA ACTATTTAAAT SEQ ID NO: 2403 CT SEQ ID NO: 2246 SEQ ID NO: 2560 AA QASQDISNYLN DASNLET QQYDILLT SEQ ID NO: 676 SEQ ID NO: 833 SEQ ID NO: 990 iPS:359865 6H1.002 NA CGGGCAAGTCAGGACATTAGAG GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCT ATTATTTAGGC SEQ ID NO: 2404 TCACT SEQ ID NO: 2247 SEQ ID NO: 2561 AA RASQDIRDYLG GASSLQS LQHNNYPFT SEQ ID NO: 677 SEQ ID NO: 834 SEQ ID NO: 991 iPS:359869 6H1.003 NA CGGGCAAGTCAGGACATTAGAG GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCT ATTATTTAGGC SEQ ID NO: 2405 TCACT SEQ ID NO: 2248 SEQ ID NO: 2562 AA RASQDIRDYLG GASSLQS LQHNNYPFT SEQ ID NO: 678 SEQ ID NO: 835 SEQ ID NO: 992 iPS:359873 6H1.004 NA CGGGCAAGTCAGGACATTAGAG GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCT ATTATTTAGGC SEQ ID NO: 2406 TCACT SEQ ID NO: 2249 SEQ ID NO: 2563 AA RASQDIRDYLG GASSLQS LQHNNYPFT SEQ ID NO: 679 SEQ ID NO: 836 SEQ ID NO: 993 iPS:359877 6H1.005 NA CGGGCAAGTCAGGACATTAGAG GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCT ATTATTTAGGC SEQ ID NO: 2407 TCACT SEQ ID NO: 2250 SEQ ID NO: 2564 AA RASQDIRDYLG GASSLQS LQHNNYPFT SEQ ID NO: 680 SEQ ID NO: 837 SEQ ID NO: 994 iPS:361067 6H1.006 NA CGGGCAAGTCAGGACATTAGAG GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCT ATTATTTAGGC SEQ ID NO: 2408 TCACT SEQ ID NO: 2251 SEQ ID NO: 2565 AA RASQDIRDYLG GASSLQS LQHNNYPFT SEQ ID NO: 681 SEQ ID NO: 838 SEQ ID NO: 995 iPS:361071 6H1.007 NA CGGGCAAGTCAGGACATTAGAG GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCT ATTATTTAGGC SEQ ID NO: 2409 TCACT SEQ ID NO: 2252 SEQ ID NO: 2566 AA RASQDIRDYLG GASSLQS LQHNNYPFT SEQ ID NO: 682 SEQ ID NO: 839 SEQ ID NO: 996 iPS:361075 6H1.008 NA CGGGCAAGTCAGGACATTAGAG GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCT ATTATTTAGGC SEQ ID NO: 2410 TCACT SEQ ID NO: 2253 SEQ ID NO: 2567 AA RASQDIRDYLG GASSLQS LQHNNYPFT SEQ ID NO: 683 SEQ ID NO: 840 SEQ ID NO: 997 iPS:361079 6A5.004.001 NA CAGGCGAGTCAGGACATTACCA GATGCTTCCAATTTGGAGCCA CAACAGTATGATGATCTATTCA ACTATTTAAAT SEQ ID NO: 2411 CT SEQ ID NO: 2254 SEQ ID NO: 2568 AA QASQDITNYLN DASNLEP QQYDDLFT SEQ ID NO: 684 SEQ ID NO: 841 SEQ ID NO: 998 iPS:361085 6A5.004.002 NA CAGGCGAGTCAGGACATTACCA GATGCTTCCAATTTGGAGCCA CAACAGTATGATGATCTATTCA ACTATTTAAAT SEQ ID NO: 2412 CT SEQ ID NO: 2255 SEQ ID NO: 2569 AA QASQDITNYLN DASNLEP QQYDDLFT SEQ ID NO: 685 SEQ ID NO: 842 SEQ ID NO: 999 iPS:361091 6A5.004.003 NA CAGGCGAGTCAGGACATTACCA GATGCTTCCAATTTGGAGCCA CAACAGTATGATGATCTATTCA ACTATTTAAAT SEQ ID NO: 2413 CT SEQ ID NO: 2256 SEQ ID NO: 2570 AA QASQDITNYLN DASNLEP QQYDDLFT SEQ ID NO: 686 SEQ ID NO: 843 SEQ ID NO: 1000 iPS:361095 6A5.004.004 NA CAGGCGAGTCAGGACATTACCA GATGCTTCCAATTTGGAGCCA CAACAGTATGATGATCTATTCA ACTATTTAAAT SEQ ID NO: 2414 CT SEQ ID NO: 2257 SEQ ID NO: 2571 AA QASQDITNYLN DASNLEP QQYDDLFT SEQ ID NO: 687 SEQ ID NO: 844 SEQ ID NO: 1001 iPS:361101 6A5.004.005 NA CAGGCGAGTCAGGACATTACCA GATGCTTCCAATTTGGAGCCA CAACAGTATGATGATCTATTCA ACTATTTAAAT SEQ ID NO: 2415 CT SEQ ID NO: 2258 SEQ ID NO: 2572 AA QASQDITNYLN DASNLEP QQYDDLFT SEQ ID NO: 688 SEQ ID NO: 845 SEQ ID NO: 1002 iPS:361105 6A5.004.006 NA CAGGCGAGTCAGGACATTACCA GATGCTTCCAATTTGGAGCCA CAACAGTATGATGATCTATTCA ACTATTTAAAT SEQ ID NO: 2416 CT SEQ ID NO: 2259 SEQ ID NO: 2573 AA QASQDITNYLN DASNLEP QQYDDLFT SEQ ID NO: 689 SEQ ID NO: 846 SEQ ID NO: 1003 iPS:361109 6A5.004.007 NA CAGGCGAGTCAGGACATTACCA GATGCTTCCAATTTGGAGCCA CAACAGTATGATGATCTATTCA ACTATTTAAAT SEQ ID NO: 2417 CT SEQ ID NO: 2260 SEQ ID NO: 2574 AA QASQDITNYLN DASNLEP QQYDDLFT SEQ ID NO: 690 SEQ ID NO: 847 SEQ ID NO: 1004 iPS:361113 6A5.004.008 NA CAGGCGAGTCAGGACATTACCA GATGCTTCCAATTTGGAGCCA CAACAGTATGATGATCTATTCA ACTATTTAAAT SEQ ID NO: 2418 CT SEQ ID NO: 2261 SEQ ID NO: 2575 AA QASQDITNYLN DASNLEP QQYDDLFT SEQ ID NO: 691 SEQ ID NO: 848 SEQ ID NO: 1005 iPS:361120 6A5.004.009 NA CAGGCGAGTCAGGACATTACCA GATGCTTCCAATTTGGAGCCA CAACAGTATGATGATCTATTCA ACTATTTAAAT SEQ ID NO: 2419 CT SEQ ID NO: 2262 SEQ ID NO: 2576 AA QASQDITNYLN DASNLEP QQYDDLFT SEQ ID NO: 692 SEQ ID NO: 849 SEQ ID NO: 1006 iPS:359896 6A5.004.010 NA CAGGCGAGTCAGGACATTACCA GATGCTTCCAATTTGGAGCCA CAACAGTATGATGATCTATTCA ACTATTTAAAT SEQ ID NO: 2420 CT SEQ ID NO: 2263 SEQ ID NO: 2577 AA QASQDITNYLN DASNLEP QQYDDLFT SEQ ID NO: 693 SEQ ID NO: 850 SEQ ID NO: 1007 iPS:359890 6A5.004.011 NA CAGGCGAGTCAGGACATTACCA GATGCTTCCAATTTGGAGCCA CAACAGTATGATGATCTATTCA ACTATTTAAAT SEQ ID NO: 2421 CT SEQ ID NO: 2264 SEQ ID NO: 2578 AA QASQDITNYLN DASNLEP QQYDDLFT SEQ ID NO: 694 SEQ ID NO: 851 SEQ ID NO: 1008 iPS:359567 2A11.002 NA AGGGCCAGTCAGATTTTTACCA GGTGCATCCAGCAGGGCCACT CAGCAGTATGGTAGCTCACCTC GCACCTACTTAGCC SEQ ID NO: 2422 GC SEQ ID NO: 2265 SEQ ID NO: 2579 AA RASQIFTSTYLA GASSRAT QQYGSSPR SEQ ID NO: 695 SEQ ID NO: 852 SEQ ID NO: 1009 iPS:335965 2A11.003 NA AGGGCCAGTCAGATTTTTACCA GGTGCATCCAGCAGGGCCACT CAGCAGTATGGTAGCTCACCTC GCACCTACTTAGCC SEQ ID NO: 2423 GC SEQ ID NO: 2266 SEQ ID NO: 2580 AA RASQIFTSTYLA GASSRAT QQYGSSPR SEQ ID NO: 696 SEQ ID NO: 853 SEQ ID NO: 1010 iPS:361158 2A11.004 NA AGGGCCAGTCAGATTTTTACCA GGTGCATCCAGCAGGGCCACT CAGCAGTATGGTAGCTCACCTC GCACCTACTTAGCC SEQ ID NO: 2424 GC SEQ ID NO: 2267 SEQ ID NO: 2581 AA RASQIFTSTYLA GASSRAT QQYGSSPR SEQ ID NO: 697 SEQ ID NO: 854 SEQ ID NO: 1011 iPS:361165 2A11.005 NA AGGGCCAGTCAGATTTTTACCA GGTGCATCCAGCAGGGCCACT CAGCAGTATGGTAGCTCACCTC GCACCTACTTAGCC SEQ ID NO: 2425 GC SEQ ID NO: 2268 SEQ ID NO: 2582 AA RASQIFTSTYLA GASSRAT QQYGSSPR SEQ ID NO: 698 SEQ ID NO: 855 SEQ ID NO: 1012 iPS:361172 2G10_LC1.003NA AGGGCCAGTCAGAGTGTTAGCA GGTGCAGCCACCAGGGCCACT CAGCAGTATAATAACTGGCCTC GCAACTTAGCC SEQ ID NO: 2426 TCACT SEQ ID NO: 2269 SEQ ID NO: 2583 AA RASQSVSSNLA GAATRAT QQYNNWPLT SEQ ID NO: 699 SEQ ID NO: 856 SEQ ID NO: 1013 iPS:361178 2G10_LC1.004 NA AGGGCCAGTCAGAGTGTTAGCA GGTGCAGCCACCAGGGCCACT CAGCAGTATAATAACTGGCCTC GCAACTTAGCC SEQ ID NO: 2427 TCACT SEQ ID NO: 2270 SEQ ID NO: 2584 AA RASQSVSSNLA GAATRAT QQYNNWPLT SEQ ID NO: 700 SEQ ID NO: 857 SEQ ID NO: 1014 iPS:361185 2G10_LC1.005 NA AGGGCCAGTCAGAGTGTTAGCA GGTGCAGCCACCAGGGCCACT CAGCAGTATAATAACTGGCCTC GCAACTTAGCC SEQ ID NO: 2428 TCACT SEQ ID NO: 2271 SEQ ID NO: 2585 AA RASQSVSSNLA GAATRAT QQYNNWPLT SEQ ID NO: 701 SEQ ID NO: 858 SEQ ID NO: 1015 iPS:361192 2G10_LC1.006 NA AGGGCCAGTCAGAGTGTTAGCA GGTGCAGCCACCAGGGCCACT CAGCAGTATAATAACTGGCCTC GCAACTTAGCC SEQ ID NO: 2429 TCACT SEQ ID NO: 2272 SEQ ID NO: 2586 AA RASQSVSSNLA GAATRAT QQYNNWPLT SEQ ID NO: 702 SEQ ID NO: 859 SEQ ID NO: 1016 iPS:359609 2G10_LC1.007 NA AGGGCCAGTCAGAGTGTTAGCA GGTGCAGCCACCAGGGCCACT CAGCAGTATAATAACTTCCCTC GCAACTTAGCC SEQ ID NO: 2430 TCACT SEQ ID NO: 2273 SEQ ID NO: 2587 AA RASQSVSSNLA GAATRAT QQYNNFPLT SEQ ID NO: 703 SEQ ID NO: 860 SEQ ID NO: 1017 iPS:359615 2G10_LC1.008 NA AGGGCCAGTCAGAGTGTTAGCA GGTGCAGCCACCAGGGCCACT CAGCAGTATAATAACTATCCTC GCAACTTAGCC SEQ ID NO: 2431 TCACT SEQ ID NO: 2274 SEQ ID NO: 2588 AA RASQSVSSNLA GAATRAT QQYNNYPLT SEQ ID NO: 704 SEQ ID NO: 861 SEQ ID NO: 1018 iPS:361196 2G10_LC1.009 NA AGGGCCAGTCAGAGTGTTAGCA GGTGCAGCCACCAGGGCCACT CAGCAGTATAATAACTGGCCTC GCAACTTAGCC SEQ ID NO: 2432 TCACT SEQ ID NO: 2275 SEQ ID NO: 2589 AA RASQSVSSNLA GAATRAT QQYNNWPLT SEQ ID NO: 705 SEQ ID NO: 862 SEQ ID NO: 1019 iPS:361202 2G10_LC1.010 NA AGGGCCAGTCAGAGTGTTAGCA GGTGCAGCCACCAGGGCCACT CAGCAGTATAATAACTGGCCTC GCAACTTAGCC SEQ ID NO: 2433 TCACT SEQ ID NO: 2276 SEQ ID NO: 2590 AA RASQSVSSNLA GAATRAT QQYNNWPLT SEQ ID NO: 706 SEQ ID NO: 863 SEQ ID NO: 1020 iPS:359644 18E3.002 NA AGGGCCAGTCAGAGTATTAGTT GGTGCATCCAGCAGGGCCACT CAGCAGTATGGTAGTTCACCGC ACAGTTACTTAGCC SEQ ID NO: 2434 TCACT SEQ ID NO: 2277 SEQ ID NO: 2591 AA RASQSISYSYLA GASSRAT QQYGSSPLT SEQ ID NO: 707 SEQ ID NO: 864 SEQ ID NO: 1021 iPS:361206 18E3.003 NA AGGGCCAGTCAGAGTATTAGTT GGTGCATCCAGCAGGGCCACT CAGCAGTATGGTAGTTCACCGC ACAGTTACTTAGCC SEQ ID NO: 2435 TCACT SEQ ID NO: 2278 SEQ ID NO: 2592 AA RASQSISYSYLA GASSRAT QQYGSSPLT SEQ ID NO: 708 SEQ ID NO: 865 SEQ ID NO: 1022 iPS:359628 18E3.004 NA AGGGCCAGTCAGAGTATTAGTT GGTGCATCCAGCAGGGCCACT CAGCAGTATGGTAGTTCACCGC ACAGTTACTTAGCC SEQ ID NO: 2436 TCACT SEQ ID NO: 2279 SEQ ID NO: 2593 AA RASQSISYSYLA GASSRAT QQYGSSPLT SEQ ID NO: 709 SEQ ID NO: 866 SEQ ID NO: 1023 iPS:359637 18E3.005 NA AGGGCCAGTCAGAGTATTAGTT GGTGCATCCAGCAGGGCCACT CAGCAGTATGGTAGTTCACCGC ACAGTTACTTAGCC SEQ ID NO: 2437 TCACT SEQ ID NO: 2280 SEQ ID NO: 2594 AA RASQSISYSYLA GASSRAT QQYGSSPLT SEQ ID NO: 710 SEQ ID NO: 867 SEQ ID NO: 1024 iPS:361210 18E3.006 NA AGGGCCAGTCAGAGTATTAGTT GGTGCATCCAGCAGGGCCACT CAGCAGTATGGTAGTTCACCGC ACAGTTACTTAGCC SEQ ID NO: 2438 TCACT SEQ ID NO: 2281 SEQ ID NO: 2595 AA RASQSISYSYLA GASSRAT QQYGSSPLT SEQ ID NO: 711 SEQ ID NO: 868 SEQ ID NO: 1025 iPS:361214 18E3.007 NA AGGGCCAGTCAGAGTATTAGTT GGTGCATCCAGCAGGGCCACT CAGCAGTATGGTAGTTCACCGC ACAGTTACTTAGCC SEQ ID NO: 2439 TCACT SEQ ID NO: 2282 SEQ ID NO: 2596 AA RASQSISYSYLA GASSRAT QQYGSSPLT SEQ ID NO: 712 SEQ ID NO: 869 SEQ ID NO: 1026 iPS:361218 18E3.007 NA AGGGCCAGTCAGAGTATTAGTT GGTGCATCCAGCAGGGCCACT CAGCAGTATGGTAGTTCACCGC ACAGTTACTTAGCC SEQ ID NO: 2440 TCACT SEQ ID NO: 2283 SEQ ID NO: 2597 AA RASQSISYSYLA GASSRAT QQYGSSPLT SEQ ID NO: 713 SEQ ID NO: 870 SEQ ID NO: 1027 iPS:361222 5C2.006 NA AAGTCCAGCCAGAGTGTTTTAT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2441 GGACG CATAGCT SEQ ID NO: 2598 SEQ ID NO: 2284 AA KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT SEQ ID NO: 714 SEQ ID NO: 871 SEQ ID NO: 1028 iPS:361229 5C2.007 NA AAGTCCAGCCAGAGTGTTTTAT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2442 GGACG CATAGCT SEQ ID NO: 2599 SEQ ID NO: 2285 AA KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT SEQ ID NO: 715 SEQ ID NO: 872 SEQ ID NO: 1029 iPS:361236 5C2.008 NA AAGTCCAGCCAGAGTGTTTTAT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2443 GGACG CATAGCT SEQ ID NO: 2600 SEQ ID NO: 2286 AA KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT SEQ ID NO: 716 SEQ ID NO: 873 SEQ ID NO: 1030 iPS:359685 5C2.009 NA AAGTCCAGCCAGAGTGTTTTAT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2444 GGACG CATAGCT SEQ ID NO: 2601 SEQ ID NO: 2287 AA KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT SEQ ID NO: 717 SEQ ID NO: 874 SEQ ID NO: 1031 iPS:361240 5C2.010 NA AAGTCCAGCCAGAGTGTTTTAT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2445 GGACG CATAGCT SEQ ID NO: 2602 SEQ ID NO: 2288 AA KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT SEQ ID NO: 718 SEQ ID NO: 875 SEQ ID NO: 1032 iPS:361247 5C2.011 NA AAGTCCAGCCAGAGTGTTTTAT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2446 GGACG CATAGCT SEQ ID NO: 2603 SEQ ID NO: 2289 AA KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT SEQ ID NO: 719 SEQ ID NO: 876 SEQ ID NO: 1033 iPS:361254 5C2.012 NA AAGTCCAGCCAGAGTGTTTTAT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2447 GGACG CATAGCT SEQ ID NO: 2604 SEQ ID NO: 2290 AA KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT SEQ ID NO: 720 SEQ ID NO: 877 SEQ ID NO: 1034 iPS:361261 5C2.013 NA AAGTCCAGCCAGAGTGTTTTAT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2448 GGACG CATAGCT SEQ ID NO: 2605 SEQ ID NO: 2291 AA KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT SEQ ID NO: 721 SEQ ID NO: 878 SEQ ID NO: 1035 iPS:361268 5C2.014 NA AAGTCCAGCCAGAGTGTTTTAT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2449 GGACG CATAGCT SEQ ID NO: 2606 SEQ ID NO: 2292 AA KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT SEQ ID NO: 722 SEQ ID NO: 879 SEQ ID NO: 1036 iPS:359669 5C2.015 NA AAGTCCAGCCAGAGTGTTTTAT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2450 GGACG CATAGCT SEQ ID NO: 2607 SEQ ID NO: 2293 AA KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT SEQ ID NO: 723 SEQ ID NO: 880 SEQ ID NO: 1037 iPS:359678 5C2.016 NA AAGTCCAGCCAGAGTGTTTTAT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2451 GGACG CATAGCT SEQ ID NO: 2608 SEQ ID NO: 2294 AA KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT SEQ ID NO: 724 SEQ ID NO: 881 SEQ ID NO: 1038 iPS:361275 11C1.002 NA AAGTCCAGCCAGAGTGTTTTAT TGGACTTCTACCCGAGAATCC CAGCAATATTATCGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2452 GGACG CTTAGCT SEQ ID NO: 2609 SEQ ID NO: 2295 AA KSSQSVLSSSNNKNYLA WTSTRES QQYYRTPWT SEQ ID NO: 725 SEQ ID NO: 882 SEQ ID NO: 1039 iPS:361282 11C1.003 NA AAGTCCAGCCAGAGTGTTTTAT TGGACTTCTACCCGAGAATCC CAGCAATATTATCGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2453 GGACG CTTAGCT SEQ ID NO: 2610 SEQ ID NO: 2296 AA KSSQSVLSSSNNKNYLA WTSTRES QQYYRTPWT SEQ ID NO: 726 SEQ ID NO: 883 SEQ ID NO: 1040 iPS:361289 11C1.004 NA AAGTCCAGCCAGAGTGTTTTAT TGGACTTCTACCCGAGATTCC CAGCAATATTATCGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2454 GGACG CTTAGCT SEQ ID NO: 2611 SEQ ID NO: 2297 AA KSSQSVLSSSNNKNYLA WTSTRDS QQYYRTPWT SEQ ID NO: 727 SEQ ID NO: 884 SEQ ID NO: 1041 iPS:359712 11C1.005 NA AAGTCCAGCCAGAGTGTTTTAT TGGACTTCTACCCGAGAATCC CAGCAATATTATCGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2455 GGACG CTTAGCT SEQ ID NO: 2612 SEQ ID NO: 2298 AA KSSQSVLSSSNNKNYLA WTSTRES QQYYRTPWT SEQ ID NO: 728 SEQ ID NO: 885 SEQ ID NO: 1042 iPS:361293 11C1.006 NA AAGTCCAGCCAGAGTGTTTTAT TGGACTTCTACCCGAGAATCC CAGCAATATTATCGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2456 GGACG CTTAGCT SEQ ID NO: 2613 SEQ ID NO: 2299 AA KSSQSVLSSSNNKNYLA WTSTRES QQYYRTPWT SEQ ID NO: 729 SEQ ID NO: 886 SEQ ID NO: 1043 iPS:361297 11C1.007 NA AAGTCCAGCCAGAGTGTTTTAT TGGACTTCTACCCGAGATTCC CAGCAATATTATCGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2457 GGACG CTTAGCT SEQ ID NO: 2614 SEQ ID NO: 2300 AA KSSQSVLSSSNNKNYLA WTSTRDS QQYYRTPWT SEQ ID NO: 730 SEQ ID NO: 887 SEQ ID NO: 1044 iPS:361301 11C1.008 NA AAGTCCAGCCAGAGTGTTTTAT TGGACTTCTACCCGAGATTCC CAGCAATATTATCGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2458 GGACG CTTAGCT SEQ ID NO: 2615 SEQ ID NO: 2301 AA KSSQSVLSSSNNKNYLA WTSTRDS QQYYRTPWT SEQ ID NO: 731 SEQ ID NO: 888 SEQ ID NO: 1045 iPS:359703 11C1.009 NA AAGTCCAGCCAGAGTGTTTTAT TGGACTTCTACCCGAGAATCC CAGCAATATTATCGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2459 GGACG CTTAGCT SEQ ID NO: 2616 SEQ ID NO: 2302 AA KSSQSVLSSSNNKNYLA WTSTRES QQYYRTPWT SEQ ID NO: 732 SEQ ID NO: 889 SEQ ID NO: 1046 iPS:361305 11C1.010 NA AAGTCCAGCCAGAGTGTTTTAT TGGACTTCTACCCGAGAATCC CAGCAATATTATCGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2460 GGACG CTTAGCT SEQ ID NO: 2617 SEQ ID NO: 2303 AA KSSQSVLSSSNNKNYLA WTSTRES QQYYRTPWT SEQ ID NO: 733 SEQ ID NO: 890 SEQ ID NO: 1047 iPS:361312 13H12.002 NA AAGTCCAGCCAGAGTGTTTTAT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2461 GGACG CATAGCT SEQ ID NO: 2618 SEQ ID NO: 2304 AA KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT SEQ ID NO: 734 SEQ ID NO: 891 SEQ ID NO: 1048 iPS:359744 13H12.003 NA AAGTCCAGCCAGAGTGTTTTAT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2462 GGACG CATAGCT SEQ ID NO: 2619 SEQ ID NO: 2305 AA KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT SEQ ID NO: 735 SEQ ID NO: 892 SEQ ID NO: 1049 iPS:361319 13H12.004 NA AAGTCCAGCCAGAGTGTTTTAT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2463 GGACG CATAGCT SEQ ID NO: 2620 SEQ ID NO: 2306 AA KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT SEQ ID NO: 736 SEQ ID NO: 893 SEQ ID NO: 1050 iPS:359737 13H12.005 NA AAGTCCAGCCAGAGTGTTTTAT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2464 GGACG CATAGCT SEQ ID NO: 2621 SEQ ID NO: 2307 AA KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT SEQ ID NO: 737 SEQ ID NO: 894 SEQ ID NO: 1051 iPS:361326 13H12.006 NA AAGTCCAGCCAGAGTGTTTTAT TGGGCATCTACCCGGGAATCC CAACAATATTATAGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2465 GGACG CATAGCT SEQ ID NO: 2622 SEQ ID NO: 2308 AA KSSQSVLSSSNNKNYIA WASTRES QQYYSTPWT SEQ ID NO: 738 SEQ ID NO: 895 SEQ ID NO: 1052 iPS:361330 12H11.002 NA AAGTCCAGCCAGAGTGTTTTAT TGGACTTCTACCCGAGATTCC CAGCAATATTATCGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2466 GGACG CTTAGCT SEQ ID NO: 2623 SEQ ID NO: 2309 AA KSSQSVLSSSNNKNYLA WTSTRDS QQYYRTPWT SEQ ID NO: 739 SEQ ID NO: 896 SEQ ID NO: 1053 iPS:361337 12H11.002 NA AAGTCCAGCCAGAGTGTTTTAT TGGACTTCTACCCGAGATTCC CAGCAATATTATCGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2467 GGACG CTTAGCT SEQ ID NO: 2624 SEQ ID NO: 2310 AA KSSQSVLSSSNNKNYLA WTSTRDS QQYYRTPWT SEQ ID NO: 740 SEQ ID NO: 897 SEQ ID NO: 1054 iPS:361344 12H11.004 NA AAGTCCAGCCAGAGTGTTTTAT TGGACTTCTACCCGAGATTCC CAGCAATATTATCGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2468 GGACG CTTAGCT SEQ ID NO: 2625 SEQ ID NO: 2311 AA KSSQSVLSSSNNKNYLA WTSTRDS QQYYRTPWT SEQ ID NO: 741 SEQ ID NO: 898 SEQ ID NO: 1055 iPS:361351 12H11.005 NA AAGTCCAGCCAGAGTGTTTTAT TGGACTTCTACCCGAGATTCC CAGCAATATTATCGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2469 GGACG CTTAGCT SEQ ID NO: 2626 SEQ ID NO: 2312 AA KSSQSVLSSSNNKNYLA WTSTRDS QQYYRTPWT SEQ ID NO: 742 SEQ ID NO: 899 SEQ ID NO: 1056 iPS:361358 12H11.006 NA AAGTCCAGCCAGAGTGTTTTAT TGGACTTCTACCCGAGATTCC CAGCAATATTATCGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2470 GGACG CTTAGCT SEQ ID NO: 2627 SEQ ID NO: 2313 AA KSSQSVLSSSNNKNYLA WTSTRDS QQYYRTPWT SEQ ID NO: 743 SEQ ID NO: 900 SEQ ID NO: 1057 iPS:361365 12H11.007 NA AAGTCCAGCCAGAGTGTTTTAT TGGACTTCTACCCGAGATTCC CAGCAATATTATCGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2471 GGACG CTTAGCT SEQ ID NO: 2628 SEQ ID NO: 2314 AA KSSQSVLSSSNNKNYLA WTSTRDS QQYYRTPWT SEQ ID NO: 744 SEQ ID NO: 901 SEQ ID NO: 1058 iPS:361372 12H11.008 NA AAGTCCAGCCAGAGTGTTTTAT TGGACTTCTACCCGAGATTCC CAGCAATATTATCGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2472 GGACG CTTAGCT SEQ ID NO: 2629 SEQ ID NO: 2315 AA KSSQSVLSSSNNKNYLA WTSTRDS QQYYRTPWT SEQ ID NO: 745 SEQ ID NO: 902 SEQ ID NO: 1059 iPS:361379 12H11.009 NA AAGTCCAGCCAGAGTGTTTTAT TGGACTTCTACCCGAGAATCC CAGCAATATTATCGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2473 GGACG CTTAGCT SEQ ID NO: 2630 SEQ ID NO: 2316 AA KSSQSVLSSSNNKNYLA WTSTRES QQYYRTPWT SEQ ID NO: 746 SEQ ID NO: 903 SEQ ID NO: 1060 iPS:361383 12H11.010 NA AAGTCCAGCCAGAGTGTTTTAT TGGACTTCTACCCGAGAATCC CAGCAATATTATCGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2474 GGACG CTTAGCT SEQ ID NO: 2631 SEQ ID NO: 2317 AA KSSQSVLSSSNNKNYLA WTSTRES QQYYRTPWT SEQ ID NO: 747 SEQ ID NO: 904 SEQ ID NO: 1061 iPS:361387 12H11.011 NA AAGTCCAGCCAGAGTGTTTTAT TGGACTTCTACCCGAGAATCC CAGCAATATTATCGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2475 GGACG CTTAGCT SEQ ID NO: 2632 SEQ ID NO: 2318 AA KSSQSVLSSSNNKNYLA WTSTRES QQYYRTPWT SEQ ID NO: 748 SEQ ID NO: 905 SEQ ID NO: 1062 iPS:361391 12H11.012 NA AAGTCCAGCCAGAGTGTTTTAT TGGACTTCTACCCGAGAATCC CAGCAATATTATCGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2476 GGACG CTTAGCT SEQ ID NO: 2633 SEQ ID NO: 2319 AA KSSQSVLSSSNNKNYLA WTSTRES QQYYRTPWT SEQ ID NO: 749 SEQ ID NO: 906 SEQ ID NO: 1063 iPS:361395 12H11.013 NA AAGTCCAGCCAGAGTGTTTTAT TGGACTTCTACCCGAGATTCC CAGCAATATTATCGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2477 GGACG CTTAGCT SEQ ID NO: 2634 SEQ ID NO: 2320 AA KSSQSVLSSSNNKNYLA WTSTRDS QQYYRTPWT SEQ ID NO: 750 SEQ ID NO: 907 SEQ ID NO: 1064 iPS:361402 12H11.014 NA AAGTCCAGCCAGAGTGTTTTAT TGGACTTCTACCCGAGAATCC CAGCAATATTATCGTACTCCGT CCAGCTCCAACAATAAGAACTA SEQ ID NO: 2478 GGACG CTTAGCT SEQ ID NO: 2635 SEQ ID NO: 2321 AA KSSQSVLSSSNNKNYLA WTSTRES QQYYRTPWT SEQ ID NO: 751 SEQ ID NO: 908 SEQ ID NO: 1065 iPS:361406 2C2.005.001 NA TCTGGAAGTAGCTCCAACATCG ACTAATAATCAGCGGCCCTCA GCAACATTCGATGAAAGCCTG GAAGTCAAACTGTAAAC SEQ ID NO: 2479 AGTGGTCCGGTA SEQ ID NO: 2322 SEQ ID NO: 2636 AA SGSSSNIGSQTVN TNNQRPS ATFDESLSGPV SEQ ID NO: 752 SEQ ID NO: 909 SEQ ID NO: 1066 iPS:361412 2C2.005.002 NA TCTGGAAGTAGCTCCAACATCG ACTAATAATCAGCGGCCCTCA GCAACATTCGATGAAAGCCTG GAAGTCAAACTGTAAAC SEQ ID NO: 2480 CAAGGTCCGGTA SEQ ID NO: 2323 SEQ ID NO: 2637 AA SGSSSNIGSQTVN TNNQRPS ATFDESLQGPV SEQ ID NO: 753 SEQ ID NO: 910 SEQ ID NO: 1067 iPS:361418 2C2.005.003 NA TCTGGAAGTAGCTCCAACATCG ACTAATAATCAGCGGCCCTCA GCAACATTCGATGAAAGCCTG GAAGTAATTATGTAAAC SEQ ID NO: 2481 AGTGGTCCGGTA SEQ ID NO: 2324 SEQ ID NO: 2638 AA SGSSSNIGSNYVN TNNQRPS ATFDESLSGPV SEQ ID NO: 754 SEQ ID NO: 911 SEQ ID NO: 1068 iPS:361424 2C2.005.004 NA TCTGGAAGTAGCTCCAACATCG ACTAATAATCAGCGGCCCTCA GCAACATTCGATGAAAGCCTG GAAGTAATTATGTAAAC SEQ ID NO: 2482 CAAGGTCCGGTA SEQ ID NO: 2325 SEQ ID NO: 2639 AA SGSSSNIGSNYVN TNNQRPS ATFDESLQGPV SEQ ID NO: 755 SEQ ID NO: 912 SEQ ID NO: 1069 iPS:361430 2C2.005.005 NA TCTGGAAGTAGCTCCAACATCG ACTAATAATCAGCGGCCCTCA GCAACATTCGATGACAGCCTG GAAGTCAAACTGTAAAC SEQ ID NO: 2483 AATGGTCCGGTA SEQ ID NO: 2326 SEQ ID NO: 2640 AA SGSSSNIGSQTVN TNNQRPS ATFDDSLNGPV SEQ ID NO: 756 SEQ ID NO: 913 SEQ ID NO: 1070 iPS:361436 2C2.005.006 NA TCTGGAAGTAGCTCCAACATCG ACTAATAATCAGCGGCCCTCA GCAACATTCGATGACAGCCTG GAAGTAATTATGTAAAC SEQ ID NO: 2484 AATGGTCCGGTA SEQ ID NO: 2327 SEQ ID NO: 2641 AA SGSSSNIGSNYVN TNNQRPS ATFDDSLNGPV SEQ ID NO: 757 SEQ ID NO: 914 SEQ ID NO: 1071 iPS:361442 2C2.005.007 NA TCTGGAAGTAGCTCCAACATCG ACTAATAATCAGCGGCCCTCA GCAACATTCGATGAAAGCCTG GAAGTAATACTGTAAAC SEQ ID NO: 2485 AATGGTCCGGTA SEQ ID NO: 2328 SEQ ID NO: 2642 AA SGSSSNIGSNTVN TNNQRPS ATFDESLNGPV SEQ ID NO: 758 SEQ ID NO: 915 SEQ ID NO: 1072 iPS:361448 2C2.005.008 NA TCTGGAAGTAGCTCCAACATCG ACTAATAATCAGCGGCCCTCA GCAACATTCGATGACAGCCTGC GAAGTAATACTGTAAAC SEQ ID NO: 2486 AAGGTCCGGTA SEQ ID NO: 2329 SEQ ID NO: 2643 AA SGSSSNIGSNTVN TNNQRPS ATFDDSLQGPV SEQ ID NO: 759 SEQ ID NO: 916 SEQ ID NO: 1073 iPS:361454 2C2.005.009 NA TCTGGAAGTAGCTCCAACATCG ACTAATAATCAGCGGCCCTCA GCAACATTCGATGACAGCCTG GAAGTAATACTGTAAAC SEQ ID NO: 2487 AGTGGTCCGGTA SEQ ID NO: 2330 SEQ ID NO: 2644 AA SGSSSNIGSNTVN TNNQRPS ATFDDSLSGPV SEQ ID NO: 760 SEQ ID NO: 917 SEQ ID NO: 1074 iPS:361460 2C2.005.010 NA TCTGGAAGTAGCTCCAACATCG ACTAATAATCAGCGGCCCTCA GCAACATTCGATGACAGCCTG GAAGTAATACTGTAAAC SEQ ID NO: 2488 AATGCTCCGGTA SEQ ID NO: 2331 SEQ ID NO: 2645 AA SGSSSNIGSNTVN TNNQRPS ATFDDSLNAPV SEQ ID NO: 761 SEQ ID NO: 918 SEQ ID NO: 1075 iPS:361466 2C2.005.011 NA TCTGGAAGTAGCTCCAACATCG ACTAATAATCAGCGGCCCTCA GCAACATTCGATAGCAGCCTG GAAGTAATACTGTAAAC SEQ ID NO: 2489 AATGGTCCGGTA SEQ ID NO: 2332 SEQ ID NO: 2646 AA SGSSSNIGSNTVN TNNQRPS ATFDSSLNGPV SEQ ID NO: 762 SEQ ID NO: 919 SEQ ID NO: 1076 iPS:361472 2C2.005.012 NA TCTGGAAGTAGCTCCAACATCG ACTAATAATCAGCGGCCCTCA GCAACATTCGATAGCAGCCTG GAAGTAATTATGTAAAC SEQ ID NO: 2490 AATGCTCCGGTA SEQ ID NO: 2333 SEQ ID NO: 2647 AA SGSSSNIGSNYVN TNNQRPS ATFDSSLNAPV SEQ ID NO: 763 SEQ ID NO: 920 SEQ ID NO: 1077 iPS:361478 2C2.005.012 NA TCTGGAAGTAGCTCCAACATCG ACTAATAATCAGCGGCCCTCA GCAACATTCGATAGCAGCCTG GAAGTAATTATGTAAAC SEQ ID NO: 2491 AATGCTCCGGTA SEQ ID NO: 2334 SEQ ID NO: 2648 AA SGSSSNIGSNYVN TNNQRPS ATFDSSLNAPV SEQ ID NO: 764 SEQ ID NO: 921 SEQ ID NO: 1078 iPS:361485 2C2.005.014 NA TCTGGAAGTAGCTCCAACATCG ACTAATAATCAGCGGCCCTCA GCAACATTCGATGAAAGCCTG GAAGTCAAACTGTAAAC SEQ ID NO: 2492 AGTGGTCCGGTA SEQ ID NO: 2335 SEQ ID NO: 2649 AA SGSSSNIGSQTVN TNNQRPS ATFDESLSGPV SEQ ID NO: 765 SEQ ID NO: 922 SEQ ID NO: 1079 iPS:361845 18F2.013 NA CGGGCAAGTCAGGACCTTAGAA GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCT ATTATTTAGGC SEQ ID NO: 2493 TCACT SEQ ID NO: 2336 SEQ ID NO: 2650 AA RASQDLRNYLG GASSLQS LQHNNYPFT SEQ ID NO: 766 SEQ ID NO: 923 SEQ ID NO: 1080 iPS:361851 6H1.009 NA CGGGCAAGTCAGGACATTAGAG GGTGCATCCAGTTTGCAAAGT CTACAGCATAATAATTACCCCT ATTATTTAGGC SEQ ID NO: 2494 TCACT SEQ ID NO: 2337 SEQ ID NO: 2651 AA RASQDIRDYLG GASSLQS LQHNNYPFT SEQ ID NO: 767 SEQ ID NO: 924 SEQ ID NO: 1081 iPS:361855 2C2.005.015 NA TCTGGAAGTAGCTCCAACATCG ACTAATAATCAGCGGCCCTCA GCAACATTCGATAGCAGCCTG GAAGTAATACTGTAAAC SEQ ID NO: 2495 AGTGGTCCGGTA SEQ ID NO: 2338 SEQ ID NO: 2652 AA SGSSSNIGSNTVN TNNQRPS ATFDSSLSGPV SEQ ID NO: 768 SEQ ID NO: 925 SEQ ID NO: 1082 iPS:336067 5G12.006 NA CGGGCAAGTCAGACCATTAGCA GTTGCATCCAGTTTGCAAAGT CAACAGAGTTACAGTACCCTG GGTTTTTAAAT SEQ ID NO: 2496 ATCAGT SEQ ID NO: 2339 SEQ ID NO: 2653 AA RASQTISRFLN VASSLQS QQSYSTLIS SEQ ID NO: 769 SEQ ID NO: 926 SEQ ID NO: 1083 iPS:336169 17B11.002 NA TCTGGAAGCAGCTCCAACATTG GACAATAATAAGCGACCCTCA GGAACATGGGATAGCAGCCTG GAAATAATTATGTATCC SEQ ID NO: 2497 AGTGCTGTGGTA SEQ ID NO: 2340 SEQ ID NO: 2654 AA SGSSSNIGNNYVS DNNKRPS GTWDSSLSAVV SEQ ID NO: 770 SEQ ID NO: 927 SEQ ID NO: 1084 iPS:361127 5G12.006.001 NA CGGGCAAGTCAGACCATTAGCA GTTGCATCCAGTTTGCAAAGT CAACAGAGTTACAGTACCCTG GGTTTTTAAAT SEQ ID NO: 2498 ATCAGT SEQ ID NO: 2341 SEQ ID NO: 2655 AA RASQTISRFLN VASSLQS QQSYSTLIS SEQ ID NO: 771 SEQ ID NO: 928 SEQ ID NO: 1085 iPS:361136 5G12.006.002 NA CGGGCAAGTCAGACCATTAGCA GTTGCATCCAGTTTGCAAAGT CAACAGAGTTACAGTACCCTG GGTTTTTAAAT SEQ ID NO: 2499 ATCAGT SEQ ID NO: 2342 SEQ ID NO: 2656 AA RASQTISRFLN VASSLQS QQSYSTLIS SEQ ID NO: 772 SEQ ID NO: 929 SEQ ID NO: 1086 iPS:361140 5G12.006.003 NA CGGGCAAGTCAGACCATTAGCA GTTGCATCCAGTTTGCAAAGT CAACAGAGTTACAGTACCCTG GGTTTTTAAAT SEQ ID NO: 2500 ATCAGT SEQ ID NO: 2343 SEQ ID NO: 2657 AA RASQTISRFLN VASSLQS QQSYSTLIS SEQ ID NO: 773 SEQ ID NO: 930 SEQ ID NO: 1087 iPS:359919 5G12.006.004 NA CGGGCAAGTCAGACCATTAGCA GTTGCATCCAGTTTGCAAAGT CAACAGAGTTACAGTACCCTG GGTTTTTAAAT SEQ ID NO: 2501 ATCAGT SEQ ID NO: 2344 SEQ ID NO: 2658 AA RASQTISRFLN VASSLQS QQSYSTLIS SEQ ID NO: 774 SEQ ID NO: 931 SEQ ID NO: 1088 iPS:361144 5G12.006.005 NA CGGGCAAGTCAGACCATTAGCA GTTGCATCCAGTTTGCAAAGT CAACAGAGTTACAGTACCCTG GGTTTTTAAAT SEQ ID NO: 2502 ATCAGT SEQ ID NO: 2345 SEQ ID NO: 2659 AA RASQTISRFLN VASSLQS QQSYSTLIS SEQ ID NO: 775 SEQ ID NO: 932 SEQ ID NO: 1089 iPS:361151 5G12.006.006 NA CGGGCAAGTCAGACCATTAGCA GTTGCATCCAGTTTGCAAAGT CAACAGAGTTACAGTACCCTG GGTTTTTAAAT SEQ ID NO: 2503 ATCAGT SEQ ID NO: 2346 SEQ ID NO: 2660 AA RASQTISRFLN VASSLQS QQSYSTLIS SEQ ID NO: 776 SEQ ID NO: 933 SEQ ID NO: 1090 iPS:361491 17B11.002.001 NA TCTGGAAGCAGCTCCAACATTG GACAATAATAAGCGACCCTCA GGAACATGGGATAGCAGCCTG GAAATAATTATGTATCC SEQ ID NO: 2504 AGTGCTGTGGTA SEQ ID NO: 2347 SEQ ID NO: 2661 AA SGSSSNIGNNYVS DNNKRPS GTWDSSLSAVV SEQ ID NO: 777 SEQ ID NO: 934 SEQ ID NO: 1091 iPS:361499 17B11.002.002 NA TCTGGAAGCAGCTCCAACATTG GACAATAATAAGCGACCCTCA GGAACATGGGATAGCAGCCTG GAAATAATTATGTATCC SEQ ID NO: 2505 AGTGCTGTGGTA SEQ ID NO: 2348 SEQ ID NO: 2662 AA SGSSSNIGNNYVS DNNKRPS GTWDSSLSAVV SEQ ID NO: 778 SEQ ID NO: 935 SEQ ID NO: 1092 iPS:361503 17B11.002.003 NA TCTGGAAGCAGCTCCAACATTG GACAATAATAAGCGACCCTCA GGAACATGGGATAGCAGCCTG GAAATAATTATGTATCC SEQ ID NO: 2506 AGTGCTGTGGTA SEQ ID NO: 2349 SEQ ID NO: 2663 AA SGSSSNIGNNYVS DNNKRPS GTWDSSLSAVV SEQ ID NO: 779 SEQ ID NO: 936 SEQ ID NO: 1093 iPS:361507 17B11.002.004 NA TCTGGAAGCAGCTCCAACATTG GACAATAATAAGCGACCCTCA GGAACATTCGAAAGCAGCCTG GAAATAATTATGTATCC SEQ ID NO: 2507 AGTGCTGTGGTA SEQ ID NO: 2350 SEQ ID NO: 2664 AA SGSSSNIGNNYVS DNNKRPS GTFESSLSAVV SEQ ID NO: 780 SEQ ID NO: 937 SEQ ID NO: 1094 iPS:361514 17B11.002.005 NA TCTGGAAGCAGCTCCAACATTG GACAATAATAAGCGACCCTCA GGAACATGGGATAGCAGCCTG GAAATAATTATGTATCC SEQ ID NO: 2508 AGTGCTGTGGTA SEQ ID NO: 2351 SEQ ID NO: 2665 AA SGSSSNIGNNYVS DNNKRPS GTWDSSLSAVV SEQ ID NO: 781 SEQ ID NO: 938 SEQ ID NO: 1095 iPS:361582 17B11.002.006 NA TCTGGAAGCAGCTCCAACATTG GACAATAATAAGCGACCCTCA GGAACATGGGATAGCAGCCTG GAAATAATTATGTATCC SEQ ID NO: 2509 AGTGCTGTGGTA SEQ ID NO: 2352 SEQ ID NO: 2666 AA SGSSSNIGNNYVS DNNKRPS GTWDSSLSAVV SEQ ID NO: 782 SEQ ID NO: 939 SEQ ID NO: 1096 iPS:361518 17B11.002.007 NA TCTGGAAGCAGCTCCAACATTG GACAATAATAAGCGACCCTCA GGAACATGGGATAGCAGCCTG GAAATAATTATGTATCC SEQ ID NO: 2510 AGTGCTGTGGTA SEQ ID NO: 2353 SEQ ID NO: 2667 AA SGSSSNIGNNYVS DNNKRPS GTWDSSLSAVV SEQ ID NO: 783 SEQ ID NO: 940 SEQ ID NO: 1097 iPS:360570 17B11.002.008 NA TCTGGAAGCAGCTCCAACATTG GACAATAATAAGCGACCCTCA GGAACATTCGAAAGCAGCCTG GAAATAATTATGTATCC SEQ ID NO: 2511 AGTGCTGTGGTA SEQ ID NO: 2354 SEQ ID NO: 2668 AA SGSSSNIGNNYVS DNNKRPS GTFESSLSAVV SEQ ID NO: 784 SEQ ID NO: 941 SEQ ID NO: 1098 iPS:362051 5G12.005.001 NA CGGGCAAGTCAGACCATTAGCA GTTGCATCCAGTTTGCAAAGT CAACAGAGTTACAGTACCCTGC GGTTTTTAAAT SEQ ID NO: 2512 TCAGT SEQ ID NO: 2355 SEQ ID NO: 2669 AA RASQTISRFLN VASSLQS QQSYSTLLS SEQ ID NO: 785 SEQ ID NO: 942 SEQ ID NO: 1099

TABLE 4B  Exemplary CDRH1, CDRH2, and CDRH3 Nucleotide and Amino Acid Sequences iPS# Ab Type CDRH1 CDRH2 CDRH3 iPS:336175 2C2.005 NA GGCTACTATATGCAT TGGATCAACCCTAACAGTGGTG GGGGGGGATTACGTTTGGGGG SEQ ID NO: 2670 GCACAAACTATGCACAGAAGT ACTTATCGGCCTCACTACTACT TTCAGGGC ACGGTATGGACGTC SEQ ID NO: 2827 SEQ ID NO: 2984 AA GYYMH WINPNSGGTNYAQKFQG GGDYVWGTYRPHYYYGMDV SEQ ID NO: 1100 SEQ ID NO: 1257 SEQ ID NO: 1414 iPS:335914 4B1 NA AACTTTGGCATGCAC GTTATATGGTATGATGGAAGTA GATGGGACGATCTTTGGAGTGG SEQ ID NO: 2671 ATGAAAACTATGCAGACTCCGT TCTTGGGGGACTAC GAAGGGC SEQ ID NO: 2985 SEQ ID NO: 2828 AA NFGMH VIWYDGSNENYADSVKG DGTIFGVVLGDY SEQ ID NO: 1101 SEQ ID NO: 1258 SEQ ID NO: 1415 iPS:335938 6H1 NA TACTTTGGCATGCAC GTTATATGGTATGATGGAAGTA GATGGGACGATTTTTGGAGTGC SEQ ID NO: 2672 ATAAATACTATGCAGACTCCGT TCTTGGGGGACTAC GAAGGGC SEQ ID NO: 2986 SEQ ID NO: 2829 AA YFGMH VIWYDGSNKYYADSVKG DGTIFGVLLGDY SEQ ID NO: 1102 SEQ ID NO: 1259 SEQ ID NO: 1416 iPS:335941 2F11 NA AGCTATGGCATGCAC GTTATATGGTATGATGGAAGTA GATAGGACGATTTTTGGAGTGG SEQ ID NO: 2673 ATAAATACTATGCAGACTCCGT TTCTTGACTAC GAAGGGC SEQ ID NO: 2987 SEQ ID NO: 2830 AA SYGMH VIWYDGSNKYYADSVKG DRTIFGVVLDY SEQ ID NO: 1103 SEQ ID NO: 1260 SEQ ID NO: 1417 iPS:335970 5C2 NA GGCTACTATATCCAC TGGATCAACCCTGACAGTGGTG GAGGCCACGATTTTTGGAATGG SEQ ID NO: 2674 GCACAGACTATTCACAGAGGTT TTATTGTACCGTTTGACTAC TCAGGGC SEQ ID NO: 2988 SEQ ID NO: 2831 AA GYYIH WINPDSGGTDYSQRFQG EATIFGMVIVPFDY SEQ ID NO: 1104 SEQ ID NO: 1261 SEQ ID NO: 1418 iPS:335978 13H12 NA GGCTACTATATCCAC TGGATCAACCCTGACAGTGGTG GAGGCCACGATTTTTGGAATGG SEQ ID NO: 2675 GCACAGACTATTCACAGAGGTT TTATTGTACCGTTTGACTAC TCAGGGC SEQ ID NO: 2989 SEQ ID NO: 2832 AA GYYIH WINPDSGGTDYSQRFQG EATIFGMVIVPFDY SEQ ID NO: 1105 SEQ ID NO: 1262 SEQ ID NO: 1419 iPS:335986 11C1 NA GGCTACTATATACAC TGGATCAGCCCTAACAGTGGTG GAGGCCACGATTTTTGGAATGC SEQ ID NO: 2676 ACACAAGCTATGCACAGAAGT TTATTGTACCATTTGACTAC TTCAGGAC SEQ ID NO: 2990 SEQ ID NO: 2833 AA GYYIH WISPNSGDTSYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1106 SEQ ID NO: 1263 SEQ ID NO: 1420 iPS:335994 12H11 NA GGCTACTATATACAC TGGATAAGCCCTAACAATGGTG GAGGCCACGATTTTTGGAATGC SEQ ID NO: 2677 ACACAAACTATGCACAGAAGT TTATTGTACCATTTGACTAC TTCAGGAC SEQ ID NO: 2991 SEQ ID NO: 2834 AA GYYIH WISPNNGDTNYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1107 SEQ ID NO: 1264 SEQ ID NO: 1421 iPS:336024 18E3 NA AGTGGTGGTTACTACTGGAGC TACATCTATTACAGTGGGAGCA GATCGTATTACGATTTTTGGAG SEQ ID NO: 2678 CCTACTACAACCCGTCCCTCAA TGGTTATGGGGGGCGGTATGG GAGT ACGTC SEQ ID NO: 2835 SEQ ID NO: 2992 AA SGGYYWS YIYYSGSTYYNPSLKS DRITIFGVVMGGGMDV SEQ ID NO: 1108 SEQ ID NO: 1265 SEQ ID NO: 1422 iPS:336041 2G10_LC1 NA AACTATGGCATGCAC GCTATATGGTTTGATGGAAGTG GATCAGGCGATTTTTGGAGTGG SEQ ID NO: 2679 ATAAATACTATGCAGACTCCGT TCCCCGACTAC GAAGGGC SEQ ID NO: 2993 SEQ ID NO: 2836 AA NYGMH AIWFDGSDKYYADSVKG DQAIFGVVPDY SEQ ID NO: 1109 SEQ ID NO: 1266 SEQ ID NO: 1423 iPS:336077 4H9.004 NA TACTTTGGCATGCAC GTTATATGGTATGATGGAAGTA GATGGGACGATTTTTGGAGTGC SEQ ID NO: 2680 ATAAATACTATGCAGACTCCGT TCTTGGGGGACTAC GAAGGGC SEQ ID NO: 2994 SEQ ID NO: 2837 AA YFGMH VIWYDGSNKYYADSVKG DGTIFGVLLGDY SEQ ID NO: 1110 SEQ ID NO: 1267 SEQ ID NO: 1424 iPS:336088 6A5.004 NA AGCTATGGCATGCAC GCTATATGGTATGATGGAAATA GATCGGACGATTTTTGGAGTGG SEQ ID NO: 2681 ATAAATACTATGCAGACTCCGT TCCTTGAGTAC GAAGGGC SEQ ID NO: 2995 SEQ ID NO: 2838 AA SYGMH AIWYDGNNKYYADSVKG DRTIFGVVLEY SEQ ID NO: 1111 SEQ ID NO: 1268 SEQ ID NO: 1425 iPS:336099 17H11.004 NA AGTTACTACTGGAGC CGTATCTATACCAGTGGGAGCA GATGTAGCAGTGGCTGGCTTTG SEQ ID NO: 2682 CCAACTACAACCCCTCCCTCAA ACTAC GAGT SEQ ID NO: 2996 SEQ ID NO: 2839 AA SYYWS RIYTSGSTNYNPSLKS DVAVAGFDY SEQ ID NO: 1112 SEQ ID NO: 1269 SEQ ID NO: 1426 iPS:359621 17H11.004.001 NA AGTTACTACTGGAGC CGTATCTATACCAGTGGGAGCA GATGTAGCAGTGGCTGGCTTTG SEQ ID NO: 2683 CCAACTACAACCCCTCCCTCAA ACTAC GAGT SEQ ID NO: 2997 SEQ ID NO: 2840 AA SYYWS RIYTSGSTNYNPSLKS DVAVAGFDY SEQ ID NO: 1113 SEQ ID NO: 1270 SEQ ID NO: 1427 iPS:359781 4H9.004.001 NA TACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA GATGGGACGATTTTTGGAGTGC SEQ ID NO: 2684 ATAAATACTATGCAGACGCCGT TCTTGGGGGACTAC GAAGGGC SEQ ID NO: 2998 SEQ ID NO: 2841 AA YFGMH VIWYDASNKYYADAVKG DGTIFGVLLGDY SEQ ID NO: 1114 SEQ ID NO: 1271 SEQ ID NO: 1428 iPS:360929 4H9.004.002 NA TACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA GATGGGACGATTTTTGGAGTGC SEQ ID NO: 2685 ATAAATACTATGCAGACTCCGT TCTTGGGGGACTAC GAAGGGC SEQ ID NO: 2999 SEQ ID NO: 2842 AA YFGMH VIWYDASNKYYADSVKG DGTIFGVLLGDY SEQ ID NO: 1115 SEQ ID NO: 1272 SEQ ID NO: 1429 iPS:360936 4H9.004.003 NA TACTTTGGCATGCAC GTTATATGGTATGATGGAAGTA GATGGGACGATTTTTGGAGTGC SEQ ID NO: 2686 ATAAATACTATGCAGACGCCGT TCTTGGGGGACTAC GAAGGGC SEQ ID NO: 3000 SEQ ID NO: 2843 AA YFGMH VIWYDGSNKYYADAVKG DGTIFGVLLGDY SEQ ID NO: 1116 SEQ ID NO: 1273 SEQ ID NO: 1430 iPS:360943 4H9.004.004 NA TACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA GATGGGACGATTTTTGGAGTGC SEQ ID NO: 2687 ATAAATACTATGCAGACGCCGT TCTTGGGGGACTAC GAAGGGC SEQ ID NO: 3001 SEQ ID NO: 2844 AA YFGMH VIWYDASNKYYADAVKG DGTIFGVLLGDY SEQ ID NO: 1117 SEQ ID NO: 1274 SEQ ID NO: 1431 iPS:360949 4H9.004.005 NA TACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA GATGGGACGATTTTTGGAGTGC SEQ ID NO: 2688 ATAAATACTATGCAGACGCCGT TCTTGGGGGACTAC GAAGGGC SEQ ID NO: 3002 SEQ ID NO: 2845 AA YFGMH VIWYDASNKYYADAVKG DGTIFGVLLGDY SEQ ID NO: 1118 SEQ ID NO: 1275 SEQ ID NO: 1432 iPS:359761 4H9.004.006 NA TACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA GATAGGACGATTTTTGGAGTGC SEQ ID NO: 2689 ATAAATACTATGCAGACGCCGT TCTTGGGGGACTAC GAAGGGC SEQ ID NO: 3003 SEQ ID NO: 2846 AA YFGMH VIWYDASNKYYADAVKG DRTIFGVLLGDY SEQ ID NO: 1119 SEQ ID NO: 1276 SEQ ID NO: 1433 iPS:360955 4B1.010 NA AACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA GATGGGACGATCTTTGGAGTGG SEQ ID NO: 2690 ATGAAAACTATGCAGACGCCG TCTTGGGGGACTAC TGAAGGGC SEQ ID NO: 3004 SEQ ID NO: 2847 AA NFGMH VIWYDASNENYADAVKG DGTIFGVVLGDY SEQ ID NO: 1120 SEQ ID NO: 1277 SEQ ID NO: 1434 iPS:360962 4B1.011 NA AACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA GATGGGACGATCTTTGGAGTGG SEQ ID NO: 2691 ATGAAAACTATGCAGACGCCG TCTTGGGGGACTAC TGAAGGGC SEQ ID NO: 3005 SEQ ID NO: 2848 AA FNGMH VIWYDASNENYADAVKG DGTIFGVVLGDY SEQ ID NO: 1121 SEQ ID NO: 1278 SEQ ID NO: 1435 iPS:360968 4B1.012 NA AACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA GATGGGACGATCTTTGGAGTGG SEQ ID NO: 2692 ATGAAAACTATGCAGACGCCG TCTTGGGGGACTAC TGAAGGGC SEQ ID NO: 3006 SEQ ID NO: 2849 AA NFGMH VIWYDASNENYADAVKG DGTIFGVVLGDY SEQ ID NO: 1122 SEQ ID NO: 1279 SEQ ID NO: 1436 iPS:360974 4B1.013 NA AACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA GATGGGACGATCTTTGGAGTGG SEQ ID NO: 2693 ATGAAAACTATGCAGACTCCGT TCTTGGGGGACTAC GAAGGGC SEQ ID NO: 3007 SEQ ID NO: 2850 AA NFGMH VIWYDASNENYADSVKG DGTIFGVVLGDY SEQ ID NO: 1123 SEQ ID NO: 1280 SEQ ID NO: 1437 iPS:360978 4B1.014 NA AACTTTGGCATGCAC GTTATATGGTATGATGGAAGTA GATGGGACGATCTTTGGAGTGG SEQ ID NO: 2694 ATGAAAACTATGCAGACGCCG TCTTGGGGGACTAC TGAAGGGC SEQ ID NO: 3008 SEQ ID NO: 2851 AA NFGMH VIWYDGSNENYADAVKG DGTIFGVVLGDY SEQ ID NO: 1124 SEQ ID NO: 1281 SEQ ID NO: 1438 iPS:359785 4B1.015 NA AACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA GATAGGACGATCTTTGGAGTGG SEQ ID NO: 2695 ATGAAAACTATGCAGACGCCG TCTTGGGGGACTAC TGAAGGGC SEQ ID NO: 3009 SEQ ID NO: 2852 AA NFGMH VIWYDASNENYADAVKG DRTIFGVVLGDY SEQ ID NO: 1125 SEQ ID NO: 1282 SEQ ID NO: 1439 iPS:360982 4B1.016 NA AACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA GATGGGACGATCTTTGGAGTGG SEQ ID NO: 2696 ATGAAAACTATGCAGACGCCG TCTTGGGGGACTAC TGAAGGGC SEQ ID NO: 3010 SEQ ID NO: 2853 AA NFGMH VIWYDASNENYADAVKG DGTIFGVVLGDY SEQ ID NO: 1126 SEQ ID NO: 1283 SEQ ID NO: 1440 iPS:335922 18F2 NA AACTTTGGCATGCAC GTTATATGGTATGATGGAAGTA GATGGGACGATCTTTGGAGTGG SEQ ID NO: 2697 ATGAAAACTATGCAGACTCCGT TCTTGGGGGACTAC GAAGGGC SEQ ID NO: 3011 SEQ ID NO: 2854 AA NFGMH VIWYDGSNENYADSVKG DGTIFGVVLGDY SEQ ID NO: 1127 SEQ ID NO: 1284 SEQ ID NO: 1441 iPS:360986 18F2.002 NA AACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA GATGGGACGATCTTTGGAGTGG SEQ ID NO: 2698 ATGAAAACTATGCAGACGCCG TCTTGGGGGACTAC TGAAGGGC SEQ ID NO: 3012 SEQ ID NO: 2855 AA NFGMH VIWYDASNENYADAVKG DGTIFGVVLGDY SEQ ID NO: 1128 SEQ ID NO: 1285 SEQ ID NO: 1442 iPS:360995 18F2.003 NA AACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA GATGGGACGATCTTTGGAGTGG SEQ ID NO: 2699 ATGAAAACTATGCAGACGCCG TCTTGGGGGACTAC TGAAGGGC SEQ ID NO: 3013 SEQ ID NO: 2856 AA NFGMH VIWYDASNENYADAVKG DGTIFGVVLGDY SEQ ID NO: 1129 SEQ ID NO: 1286 SEQ ID NO: 1443 iPS:360999 18F2.004 NA AACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA GATGGGACGATCTTTGGAGTGG SEQ ID NO: 2700 ATGAAAACTATGCAGACGCCG TCTTGGGGGACTAC TGAAGGGC SEQ ID NO: 3014 SEQ ID NO: 2857 AA NFGMH VIWYDASNENYADAVKG DGTIFGVVLGDY SEQ ID NO: 1130 SEQ ID NO: 1287 SEQ ID NO: 1444 iPS:361005 18F2.005 NA AACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA GATGGGACGATCTTTGGAGTGG SEQ ID NO: 2701 ATGAAAACTATGCAGACGCCG TCTTGGGGGACTAC TGAAGGGC SEQ ID NO: 3015 SEQ ID NO: 2858 AA NFGMH VIWYDASNENYADAVKG DGTIFGVVLGDY SEQ ID NO: 1131 SEQ ID NO: 1288 SEQ ID NO: 1445 iPS:361009 18F2.006 NA AACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA GATGGGACGATCTTTGGAGTGG SEQ ID NO: 2702 ATGAAAACTATGCAGACGCCG TCTTGGGGGACTAC TGAAGGGC SEQ ID NO: 3016 SEQ ID NO: 2859 AA NFGMH VIWYDASNENYADAVKG DGTIFGVVLGDY SEQ ID NO: 1132 SEQ ID NO: 1289 SEQ ID NO: 1446 iPS:361013 18F2.007 NA AACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA GATGGGACGATCTTTGGAGTGG SEQ ID NO: 2703 ATGAAAACTATGCAGACGCCG TCTTGGGGGACTAC TGAAGGGC SEQ ID NO: 3017 SEQ ID NO: 2860 AA NFGMH VIWYDASNENYADAVKG DGTIFGVVLGDY SEQ ID NO: 1133 SEQ ID NO: 1290 SEQ ID NO: 1447 iPS:361017 18F2.008 NA AACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA GATGGGACGATCTTTGGAGTGG SEQ ID NO: 2704 ATGAAAACTATGCAGACGCCG TCTTGGGGGACTAC TGAAGGGC SEQ ID NO: 3018 SEQ ID NO: 2861 AA NFGMH VIWYDASNENYADAVKG DGTIFGVVLGDY SEQ ID NO: 1134 SEQ ID NO: 1291 SEQ ID NO: 1448 iPS:361021 18F2.009 NA AACTTTGGCATGCAC GTTATATGGTATGATGGAAGTA GATGGGACGATCTTTGGAGTGG SEQ ID NO: 2705 ATGAAAACTATGCAGACGCCG TCTTGGGGGACTAC TGAAGGGC SEQ ID NO: 3019 SEQ ID NO: 2862 AA NFGMH VIWYDGSNENYADAVKG DGTIFGVVLGDY SEQ ID NO: 1135 SEQ ID NO: 1292 SEQ ID NO: 1449 iPS:361028 18F2.010 NA AACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA GATGGGACGATCTTTGGAGTGG SEQ ID NO: 2706 ATGAAAACTATGCAGACTCCGT TCTTGGGGGACTAC GAAGGGC SEQ ID NO: 3020 SEQ ID NO: 2863 AA NFGMH VIWYDASNENYADSVKG DGTIFGVVLGDY SEQ ID NO: 1136 SEQ ID NO: 1293 SEQ ID NO: 1450 iPS:360535 18F2.011 NA AACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA GATAGGACGATCTTTGGAGTGG SEQ ID NO: 2707 ATGAAAACTATGCAGACGCCG TCTTGGGGGACTAC TGAAGGGC SEQ ID NO: 3021 SEQ ID NO: 2864 AA NFGMH VIWYDASNENYADAVKG DRTIFGVVLGDY SEQ ID NO: 1137 SEQ ID NO: 1294 SEQ ID NO: 1451 iPS:361035 18F2.012 NA AACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA GATGGGACGATCTTTGGAGTGG SEQ ID NO: 2708 ATGAAAACTATGCAGACGCCG TCTTGGGGGACTAC TGAAGGGC SEQ ID NO: 3022 SEQ ID NO: 2865 AA NFGMH VIWYDASNENYADAVKG DGTIFGVVLGDY SEQ ID NO: 1138 SEQ ID NO: 1295 SEQ ID NO: 1452 iPS:359940 2F11.002 NA AGCTATGGCATGCAC GTTATATGGTATGATGCAAGTA GATAGGACGATTTTTGGAGTGG SEQ ID NO: 2709 ATAAATACTATGCAGACGCCGT TTCTTGACTAC GAAGGGC SEQ ID NO: 3023 SEQ ID NO: 2866 AA SYGMH VIWYDASNKYYADAVKG DRTIFGVVLDY SEQ ID NO: 1139 SEQ ID NO: 1296 SEQ ID NO: 1453 iPS:361039 2F11.003 NA AGCTATGGCATGCAC GTTATATGGTATGATGCAAGTA GATAGGACGATTTTTGGAGTGG SEQ ID NO: 2710 ATAAATACTATGCAGACGCCGT TTCTTGACTAC GAAGGGC SEQ ID NO: 3024 SEQ ID NO: 2867 AA SYGMH VIWYDASNKYYADAVKG DRTIFGVVLDY SEQ ID NO: 1140 SEQ ID NO: 1297 SEQ ID NO: 1454 iPS:361043 2F11.004 NA AGCTATGGCATGCAC GTTATATGGTATGATGCAAGTA GATAGGACGATTTTTGGAGTGG SEQ ID NO: 2711 ATAAATACTATGCAGACGCCGT TTCTTGACTAC GAAGGGC SEQ ID NO: 3025 SEQ ID NO: 2868 AA SYGMH VIWYDASNKYYADAVKG DRTIFGVVLDY SEQ ID NO: 1141 SEQ ID NO: 1298 SEQ ID NO: 1455 iPS:361049 2F11.005 NA AGCTATGGCATGCAC GTTATATGGTATGATGCAAGTA GATAGGACGATTTTTGGAGTGG SEQ ID NO: 2712 ATAAATACTATGCAGACGCCGT TTCTTGACTAC GAAGGGC SEQ ID NO: 3026 SEQ ID NO: 2869 AA SYGMH VIWYDASNKYYADAVKG DRTIFGVVLDY SEQ ID NO: 1142 SEQ ID NO: 1299 SEQ ID NO: 1456 iPS:361055 2F11.006 NA AGCTATGGCATGCAC GTTATATGGTATGATGCAAGTA GATAGGACGATTTTTGGAGTGG SEQ ID NO: 2713 ATAAATACTATGCAGACGCCGT TTCTTGACTAC GAAGGGC SEQ ID NO: 3027 SEQ ID NO: 2870 AA SYGMH VIWYDASNKYYADAVKG DRTIFGVVLDY SEQ ID NO: 1143 SEQ ID NO: 1300 SEQ ID NO: 1457 iPS:361059 2F11.007 NA AGCTATGGCATGCAC GTTATATGGTATGATGCAAGTA GATAGGACGATTTTTGGAGTGG SEQ ID NO: 2714 ATAAATACTATGCAGACGCCGT TTCTTGACTAC GAAGGGC SEQ ID NO: 3028 SEQ ID NO: 2871 AA SYGMH VIWYDASNKYYADAVKG DRTIFGVVLDY SEQ ID NO: 1144 SEQ ID NO: 1301 SEQ ID NO: 1458 iPS:361063 2F11.008 NA AGCTATGGCATGCAC GTTATATGGTATGATGCAAGTA GATAGGACGATTTTTGGAGTGG SEQ ID NO: 2715 ATAAATACTATGCAGACGCCGT TTCTTGACTAC GAAGGGC SEQ ID NO: 3029 SEQ ID NO: 2872 AA SYGMH VIWYDASNKYYADAVKG DRTIFGVVLDY SEQ ID NO: 1145 SEQ ID NO: 1302 SEQ ID NO: 1459 iPS:359949 2F11.009 NA AGCTATGGCATGCAC GTTATATGGTATGATGCAAGTA GATAGGACGATTTTTGGAGTGG SEQ ID NO: 2716 ATAAATACTATGCAGACTCCGT TTCTTGACTAC GAAGGGC SEQ ID NO: 3030 SEQ ID NO: 2873 AA SYGMH VIWYDASNKYYADSVKG DRTIFGVVLDY SEQ ID NO: 1146 SEQ ID NO: 1303 SEQ ID NO: 1460 iPS:359956 2F11.010 NA AGCTATGGCATGCAC GTTATATGGTATGATGGAAGTA GATAGGACGATTTTTGGAGTGG SEQ ID NO: 2717 ATAAATACTATGCAGACGCCGT TTCTTGACTAC GAAGGGC SEQ ID NO: 3031 SEQ ID NO: 2874 AA SYGMH VIWYDGSNKYYADAVKG DRTIFGVVLDY SEQ ID NO: 1147 SEQ ID NO: 1304 SEQ ID NO: 1461 iPS:359865 6H1.002 NA TACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA GATGGGACGATTTTTGGAGTGC SEQ ID NO: 2718 ATAAATACTATGCAGACGCCGT TCTTGGGGGACTAC GAAGGGC SEQ ID NO: 3032 SEQ ID NO: 2875 AA YFGMH VIWYDASNKYYADAVKG DGTIFGVLLGDY SEQ ID NO: 1148 SEQ ID NO: 1305 SEQ ID NO: 1462 iPS:359869 6H1.003 NA TACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA GATAGGACGATTTTTGGAGTGC SEQ ID NO: 2719 ATAAATACTATGCAGACGCCGT TCTTGGGGGACTAC GAAGGGC SEQ ID NO: 3033 SEQ ID NO: 2876 AA YFGMH VIWYDASNKYYADAVKG DRTIFGVLLGDY SEQ ID NO: 1149 SEQ ID NO: 1306 SEQ ID NO: 1463 iPS:359873 6H1.004 NA TACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA GATGGGACGATTTTTGGAGTGC SEQ ID NO: 2720 ATAAATACTATGCAGACGCCGT TCTTGGGGGACTAC GAAGGGC SEQ ID NO: 3034 SEQ ID NO: 2877 AA YFGMH VIWYDASNKYYADAVKG DGTIFGVLLGDY SEQ ID NO: 1150 SEQ ID NO: 1307 SEQ ID NO: 1464 iPS:359877 6H1.005 NA TACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA GATAGGACGATTTTTGGAGTGC SEQ ID NO: 2721 ATAAATACTATGCAGACGCCGT TCTTGGGGGACTAC GAAGGGC SEQ ID NO: 3035 SEQ ID NO: 2878 AA YFGMH VIWYDASNKYYADAVKG DRTIFGVLLGDY SEQ ID NO: 1151 SEQ ID NO: 1308 SEQ ID NO: 1465 iPS:361067 6H1.006 NA TACTTTGGCATGCAC GTTATATGGTATGATGGAAGTA GATGGGACGATTTTTGGAGTGC SEQ ID NO: 2722 ATAAATACTATGCAGACTCCGT TCTTGGGGGACTAC GAAGGGC SEQ ID NO: 3036 SEQ ID NO: 2879 AA YFGMH VIWYDGSNKYYADSVKG DGTIFGVLLGDY SEQ ID NO: 1152 SEQ ID NO: 1309 SEQ ID NO: 1466 iPS:361071 6H1.007 NA TACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA GATGGGACGATTTTTGGAGTGC SEQ ID NO: 2723 ATAAATACTATGCAGACTCCGT TCTTGGGGGACTAC GAAGGGC SEQ ID NO: 3037 SEQ ID NO: 2880 AA YFGMH VIWYDASNKYYADSVKG DGTIFGVLLGDY SEQ ID NO: 1153 SEQ ID NO: 1310 SEQ ID NO: 1467 iPS:361075 6H1.008 NA TACTTTGGCATGCAC GTTATATGGTATGATGGAAGTA GATGGGACGATTTTTGGAGTGC SEQ ID NO: 2724 ATAAATACTATGCAGACGCCGT TCTTGGGGGACTAC GAAGGGC SEQ ID NO: 3038 SEQ ID NO: 2881 AA YFGMH VIWYDGSNKYYADAVKG DGTIFGVLLGDY SEQ ID NO: 1154 SEQ ID NO: 1311 SEQ ID NO: 1468 iPS:361079 6A5.004.001 NA AGCTATGGCATGCAC GCTATATGGTATGATGCAAATA GATCGGACGATTTTTGGAGTGG SEQ ID NO: 2725 ATAAATACTATGCAGACGCCGT TCCTTGAGTAC GAAGGGC SEQ ID NO: 3039 SEQ ID NO: 2882 AA SYGMH AIWYDANNKYYADAVKG DRTIFGVVLEY SEQ ID NO: 1155 SEQ ID NO: 1312 SEQ ID NO: 1469 iPS:361085 6A5.004.002 NA AGCTATGGCATGCAC GCTATATGGTATGATGCAAATA GATCGGACGATTTTTGGAGTGG SEQ ID NO: 2726 ATAAATACTATGCAGACGCCGT TCCTTGAGTAC GAAGGGC SEQ ID NO: 3040 SEQ ID NO: 2883 AA SYGMH AIWYDANNKYYADAVKG DRTIFGVVLEY SEQ ID NO: 1156 SEQ ID NO: 1313 SEQ ID NO: 1470 iPS:361091 6A5.004.003 NA AGCTATGGCATGCAC GCTATATGGTATGATGCAAATA GATCGGACGATTTTTGGAGTGG SEQ ID NO: 2727 ATAAATACTATGCAGACGCCGT TCCTTGAGTAC GAAGGGC SEQ ID NO: 3041 SEQ ID NO: 2884 AA SYGMH AIWYDANNKYYADAVKG DRTIFGVVLEY SEQ ID NO: 1157 SEQ ID NO: 1314 SEQ ID NO: 1471 iPS:361095 6A5.004.004 NA AGCTATGGCATGCAC GCTATATGGTATGATGCAAATA GATCGGACGATTTTTGGAGTGG SEQ ID NO: 2728 ATAAATACTATGCAGACGCCGT TCCTTGAGTAC GAAGGGC SEQ ID NO: 3042 SEQ ID NO: 2885 AA SYGMH AIWYDANNKYYADAVKG DRTIFGVVLEY SEQ ID NO: 1158 SEQ ID NO: 1315 SEQ ID NO: 1472 iPS:361101 6A5.004.005 NA AGCTATGGCATGCAC GCTATATGGTATGATGCAAATA GATCGGACGATTTTTGGAGTGG SEQ ID NO: 2729 ATAAATACTATGCAGACGCCGT TCCTTGAGTAC GAAGGGC SEQ ID NO: 3043 SEQ ID NO: 2886 AA SYGMH AIWYDANNKYYADAVKG DRTIFGVVLEY SEQ ID NO: 1159 SEQ ID NO: 1316 SEQ ID NO: 1473 iPS:361105 6A5.004.006 NA AGCTATGGCATGCAC GCTATATGGTATGATGCAAATA GATCGGACGATTTTTGGAGTGG SEQ ID NO: 2730 ATAAATACTATGCAGACGCCGT TCCTTGAGTAC GAAGGGC SEQ ID NO: 3044 SEQ ID NO: 2887 AA SYGMH AIWYDANNKYYADAVKG DRTIFGVVLEY SEQ ID NO: 1160 SEQ ID NO: 1317 SEQ ID NO: 1474 iPS:361109 6A5.004.007 NA AGCTATGGCATGCAC GCTATATGGTATGATGCAAATA GATCGGACGATTTTTGGAGTGG SEQ ID NO: 2731 ATAAATACTATGCAGACGCCGT TCCTTGAGTAC GAAGGGC SEQ ID NO: 3045 SEQ ID NO: 2888 AA SYGMH AIWYDANNKYYADAVKG DRTIFGVVLEY SEQ ID NO: 1161 SEQ ID NO: 1318 SEQ ID NO: 1475 iPS:361113 6A5.004.008 NA AGCTATGGCATGCAC GCTATATGGTATGATGGAAATA GATCGGACGATTTTTGGAGTGG SEQ ID NO: 2732 ATAAATACTATGCAGACGCCGT TCCTTGAGTAC GAAGGGC SEQ ID NO: 3046 SEQ ID NO: 2889 AA SYGMH AIWYDGNNKYYADAVKG DRTIFGVVLEY SEQ ID NO: 1162 SEQ ID NO: 1319 SEQ ID NO: 1476 iPS:361120 6A5.004.009 NA AGCTATGGCATGCAC GCTATATGGTATGATGCAAATA GATCGGACGATTTTTGGAGTGG SEQ ID NO: 2733 ATAAATACTATGCAGACTCCGT TCCTTGAGTAC GAAGGGC SEQ ID NO: 3047 SEQ ID NO: 2890 AA SYGMH AIWYDANNKYYADSVKG DRTIFGVVLEY SEQ ID NO: 1163 SEQ ID NO: 1320 SEQ ID NO: 1477 iPS:359896 6A5.004.010 NA AGCTATGGCATGCAC GCTATATGGTATGATGCAAATA GATCGGACGATTTTTGGAGTGG SEQ ID NO: 2734 ATAAATACTATGCAGACGCCGT TCCTTGAGTAC GAAGGGC SEQ ID NO: 3048 SEQ ID NO: 2891 AA SYGMH AIWYDANNKYYADAVKG DRTIFGVVLEY SEQ ID NO: 1164 SEQ ID NO: 1321 SEQ ID NO: 1478 iPS:359890 6A5.004.011 NA AGCTATGGCATGCAC GCTATATGGTATGATGCAAATA GATCGGACGATTTTTGGAGTGG SEQ ID NO: 2735 ATAAATACTATGCAGACGCCGT TCCTTGAGTAC GAAGGGC SEQ ID NO: 3049 SEQ ID NO: 2892 AA SYGMH AIWYDANNKYYADAVKG DRTIFGVVLEY SEQ ID NO: 1165 SEQ ID NO: 1322 SEQ ID NO: 1479 iPS:359567 2A11.002 NA AGCTATGGCATGCAC GTTATATGGTATGATGCAAGTA GGGATTACGATTTTTGGTCATG SEQ ID NO: 2736 ATAAATACTATGAAGACGCCGT GGTTTGAATAT GAAGGGC SEQ ID NO: 3050 SEQ ID NO: 2893 AA SYGMH VIWYDASNKYYEDAVKG GITIFGHGFEY SEQ ID NO: 1166 SEQ ID NO: 1323 SEQ ID NO: 1480 iPS:335965 2A11.003 NA AGCTATGGCATGCAC GTTATATGGTATGATGGAAGTA GGGATTACGATTTTTGGTCATG SEQ ID NO: 2737 ATAAATACTATGAAGACTCCGT GGTTTGAATAT GAAGGGC SEQ ID NO: 3051 SEQ ID NO: 2894 AA SYGMH VIWYDGSNKYYEDSVKG GITIFGHGFEY SEQ ID NO: 1167 SEQ ID NO: 1324 SEQ ID NO: 1481 iPS:361158 2A11.004 NA AGCTATGGCATGCAC GTTATATGGTATGATGGAAGTA GGGATTACGATTTTTGGTCATG SEQ ID NO: 2738 ATAAATACTATGAAGACGCCGT GGTTTGAATAT GAAGGGC SEQ ID NO: 3052 SEQ ID NO: 2895 AA SYGMH VIWYDGSNKYYEDAVKG GITIFGHGFEY SEQ ID NO: 1168 SEQ ID NO: 1325 SEQ ID NO: 1482 iPS:361165 2A11.005 NA AGCTATGGCATGCAC GTTATATGGTATGATGCAAGTA GGGATTACGATTTTTGGTCATG SEQ ID NO: 2739 ATAAATACTATGAAGACTCCGT GGTTTGAATAT GAAGGGC SEQ ID NO: 3053 SEQ ID NO: 2896 AA SYGMH VIWYDASNKYYEDSVKG GITIFGHGFEY SEQ ID NO: 1169 SEQ ID NO: 1326 SEQ ID NO: 1483 iPS:361172 2G10_LC1.003 NA AACTATGGCATGCAC GCTATATGGTTTGATGCAAGTG GATCAGGCGATTTTTGGAGTGG SEQ ID NO: 2740 ATAAATACTATGCAGACGCCGT TCCCCGACTAC GAAGGGC SEQ ID NO: 3054 SEQ ID NO: 2897 AA NYGMH AIWFDASDKYYADAVKG DQAIFGVVPDY SEQ ID NO: 1170 SEQ ID NO: 1327 SEQ ID NO: 1484 iPS:361178 2G10_LC1.004 NA AACTATGGCATGCAC GCTATATGGTTTGATGCAAGTG GATCAGGCGATTTTTGGAGTGG SEQ ID NO: 2741 ATAAATACTATGCAGACTCCGT TCCCCGACTAC GAAGGGC SEQ ID NO: 3055 SEQ ID NO: 2898 AA NYGMH AIWFDASDKYYADSVKG DQAIFGVVPDY SEQ ID NO: 1171 SEQ ID NO: 1328 SEQ ID NO: 1485 iPS:361185 2G10_LC1.005 NA AACTATGGCATGCAC GCTATATGGTTTGATGGAAGTG GATCAGGCGATTTTTGGAGTGG SEQ ID NO: 2742 ATAAATACTATGCAGACGCCGT TCCCCGACTAC GAAGGGC SEQ ID NO: 3056 SEQ ID NO: 2899 AA NYGMH AIWFDGSDKYYADAVKG DQAIFGVVPDY SEQ ID NO: 1172 SEQ ID NO: 1329 SEQ ID NO: 1486 iPS:361192 2G10_LC1.006 NA AACTATGGCATGCAC GCTATATGGTTTGATGCAAGTG GATCAGGCGATTTTTGGAGTGG SEQ ID NO: 2743 ATAAATACTATGCAGACGCCGT TCCCCGACTAC GAAGGGC SEQ ID NO: 3057 SEQ ID NO: 2900 AA NYGMH AIWFDASDKYYADAVKG DQAIFGVVPDY SEQ ID NO: 1173 SEQ ID NO: 1330 SEQ ID NO: 1487 iPS:359609 2G10_LC1.007 NA AACTATGGCATGCAC GCTATATGGTTTGATGCAAGTG GATCAGGCGATTTTTGGAGTGG SEQ ID NO: 2744 ATAAATACTATGCAGACGCCGT TCCCCGACTAC GAAGGGC SEQ ID NO: 3058 SEQ ID NO: 2901 AA NYGMH AIWFDASDKYYADAVKG DQAIFGVVPDY SEQ ID NO: 1174 SEQ ID NO: 1331 SEQ ID NO: 1488 iPS:359615 2G10_LC1.008 NA AACTATGGCATGCAC GCTATATGGTTTGATGCAAGTG GATCAGGCGATTTTTGGAGTGG SEQ ID NO: 2745 ATAAATACTATGCAGACGCCGT TCCCCGACTAC GAAGGGC SEQ ID NO: 3059 SEQ ID NO: 2902 AA NYGMH AIWFDASDKYYADAVKG DQAIFGVVPDY SEQ ID NO: 1175 SEQ ID NO: 1332 SEQ ID NO: 1489 iPS:361196 2G10_LC1.009 NA AACTATGGCATGCAC GCTATATGGTTTGATGCAAGTG GATCAGGCGATTTTTGGAGTGG SEQ ID NO: 2746 ATAAATACTATGCAGACGCCGT TCCCCGACTAC GAAGGGC SEQ ID NO: 3060 SEQ ID NO: 2903 AA NYGMH AIWFDASDKYYADAVKG DQAIFGVVPDY SEQ ID NO: 1176 SEQ ID NO: 1333 SEQ ID NO: 1490 iPS:361202 2G10_LC1.010 NA AACTATGGCATGCAC GCTATATGGTTTGATGCAAGTG GATCAGGCGATTTTTGGAGTGG SEQ ID NO: 2747 ATAAATACTATGCAGACGCCGT TCCCCGACTAC GAAGGGC SEQ ID NO: 3061 SEQ ID NO: 2904 AA NYGMH AIWFDASDKYYADAVKG DQAIFGVVPDY SEQ ID NO: 1177 SEQ ID NO: 1334 SEQ ID NO: 1491 iPS:359644 18E3.002 NA AGTGGTGGTTACTACTGGAGC TACATCTATTACAGTGGGAGCA GATCGTATTACGATTTTTGGAG SEQ ID NO: 2748 CCTACTACAACCCGTCCCTCAA TGGTTATGGGGGGCGGTATGG GAGT ACGTC SEQ ID NO: 2905 SEQ ID NO: 3062 AA SGGYYWS YIYYSGSTYYNPSLKS DRITIFGVVMGGGMDV SEQ ID NO: 1178 SEQ ID NO: 1335 SEQ ID NO: 1492 iPS:361206 18E3.003 NA AGTGGTGGTTACTACTGGAGC TACATCTATTACAGTGGGAGCA GATCGTATTACGATTTTTGGAG SEQ ID NO: 2749 CCTACTACAACCCGTCCCTCAA TGGTTATGGGGGGCGGTATGG GAGT ACGTC SEQ ID NO: 2906 SEQ ID NO: 3063 AA SGGYYWS YIYYSGSTYYNPSLKS DRITIFGVVMGGGMDV SEQ ID NO: 1179 SEQ ID NO: 1336 SEQ ID NO: 1493 iPS:359628 18E3.004 NA AGTGGTGGTTACTACTGGAGC TACATCTATTACAGTGGGAGCA GATCGTATTACGATTTTTGGAG SEQ ID NO: 2750 CCTACTACAACCCGTCCCTCAA TGGTTATGGGGGGCGGTATGG GAGT ACGTC SEQ ID NO: 2907 SEQ ID NO: 3064 AA SGGYYWS YIYYSGSTYYNPSLKS DRITIFGVVMGGGMDV SEQ ID NO: 1180 SEQ ID NO: 1337 SEQ ID NO: 1494 iPS:359637 18E3.005 NA AGTGGTGGTTACTACTGGAGC TACATCTATTACAGTGGGAGCA GATCGTATTACGATTTTTGGAG SEQ ID NO: 2751 CCTACTACAACCCGTCCCTCAA TGGTTATGGGGGGCGGTATGG GAGT ACGTC SEQ ID NO: 2908 SEQ ID NO: 3065 AA SGGYYWS YIYYSGSTYYNPSLKS DRITIFGVVMGGGMDV SEQ ID NO: 1181 SEQ ID NO: 1338 SEQ ID NO: 1495 iPS:361210 18E3.006 NA AGTGGTGGTTACTACTGGAGC TACATCTATTACAGTGGGAGCA GATCGTATTACGATTTTTGGAG SEQ ID NO: 2752 CCTACTACAACCCGTCCCTCAA TGGTTATGGGGGGCGGTATGG GAGT ACGTC SEQ ID NO: 2909 SEQ ID NO: 3066 AA SGGYYWS YIYYSGSTYYNPSLKS DRITIFGVVMGGGMDV SEQ ID NO: 1182 SEQ ID NO: 1339 SEQ ID NO: 1496 iPS:361214 18E3.007 NA AGTGGTGGTTACTACTGGAGC TACATCTATTACAGTGGGAGCA GATCGTATTACGATTTTTGGAG SEQ ID NO: 2753 CCTACTACAACCCGTCCCTCAA TGGTTATGGGGGGCGGTATGG GAGT ACGTC SEQ ID NO: 2910 SEQ ID NO: 3067 AA SGGYYWS YIYYSGSTYYNPSLKS DRITIFGVVMGGGMDV SEQ ID NO: 1183 SEQ ID NO: 1340 SEQ ID NO: 1497 iPS:361218 18E3.008 NA AGTGGTGGTTACTACTGGAGC TACATCTATTACAGTGGGAGCA GATCGTATTACGATTTTTGGAG SEQ ID NO: 2754 CCTACTACAACCCGTCCCTCAA TGGTTATGGGGGGCGGTATGG GAGT ACGTC SEQ ID NO: 2911 SEQ ID NO: 3068 AA SGGYYWS YIYYSGSTYYNPSLKS DRITIFGVVMGGGMDV SEQ ID NO: 1184 SEQ ID NO: 1341 SEQ ID NO: 1498 iPS:361222 5C2.006 NA GGCTACTATATCCAC TGGATCAACCCTGAAAGTGGTG GAGGCCACGATTTTTGGAATGG SEQ ID NO: 2755 GCACAGACTATTCACAGAGGTT TTATTGTACCGTTTGACTAC TCAGGGC SEQ ID NO: 3069 SEQ ID NO: 2912 AA GYYIH WINPESGGTDYSQRFQG EATIFGMVIVPFDY SEQ ID NO: 1185 SEQ ID NO: 1342 SEQ ID NO: 1499 iPS:361229 5C2.007 NA GGCTACTATATCCAC TGGATCAACCCTGAAAGTGGTG GAGGCCACGATTTTTGGAATGG SEQ ID NO: 2756 GCACAGACTATTCACAGAGGTT TTATTGTACCGTTTGACTAC TCAGGGC SEQ ID NO: 3070 SEQ ID NO: 2913 AA GYYIH WINPESGGTDYSQRFQG EATIFGMVIVPFDY SEQ ID NO: 1186 SEQ ID NO: 1343 SEQ ID NO: 1500 iPS:361236 5C2.008 NA GGCTACTATATCCAC TGGATCAACCCTGACGCTGGTG GAGGCCACGATTTTTGGAATGG SEQ ID NO: 2757 GCACAGACTATTCACAGAGGTT TTATTGTACCGTTTGACTAC TCAGGGC SEQ ID NO: 3071 SEQ ID NO: 2914 AA GYYIH WINPDAGGTDYSQRFQG EATIFGMVIVPFDY SEQ ID NO: 1187 SEQ ID NO: 1344 SEQ ID NO: 1501 iPS:359685 5C2.009 NA GGCTACTATATCCAC TGGATCAACCCTGACGCTGGTG GAGGCCACGATTTTTGGAATGG SEQ ID NO: 2758 GCACAGACTATTCACAGAGGTT TTATTGTACCGTTTGACTAC TCAGGGC SEQ ID NO: 3072 SEQ ID NO: 2915 AA GYYIH WINPDAGGTDYSQRFQG EATIFGMVIVPFDY SEQ ID NO: 1188 SEQ ID NO: 1345 SEQ ID NO: 1502 iPS:361240 5C2.010 NA GGCTACTATATCCAC TGGATCAACCCTGACAGTGGTG GAGGCCACGATTTTTGGAATGG SEQ ID NO: 2759 GCACAGACTATTCACAGAGGTT TTATTGTACCGTTTGACTAC TCAGGGC SEQ ID NO: 3073 SEQ ID NO: 2916 AA GYYIH WINPDSGGTDYSQRFQG EATIFGMVIVPFDY SEQ ID NO: 1189 SEQ ID NO: 1346 SEQ ID NO: 1503 iPS:361247 5C2.011 NA GGCTACTATATCCAC TGGATCAACCCTGACAGTGGTG GAGGCCACGATTTTTGGAATGG SEQ ID NO: 2760 GCACAGACTATTCACAGAGGTT TTATTGTACCGTTTGACTAC TCAGGGC SEQ ID NO: 3074 SEQ ID NO: 2917 AA GYYIH WINPDSGGTDYSQRFQG EATIFGMVIVPFDY SEQ ID NO: 1190 SEQ ID NO: 1347 SEQ ID NO: 1504 iPS:361254 5C2.012 NA GGCTACTATATCCAC TGGATCAACCCTGACAGTGGTG GAGGCCACGATTTTTGGAATGG SEQ ID NO: 2761 GCACAGACTATTCACAGAGGTT TTATTGTACCGTTTGACTAC TCAGGGC SEQ ID NO: 3075 SEQ ID NO: 2918 AA GYYIH WINPDSGGTDYSQRFQG EATIFGMVIVPFDY SEQ ID NO: 1191 SEQ ID NO: 1348 SEQ ID NO: 1505 iPS:361261 5C2.013 NA GGCTACTATATCCAC TGGATCAACCCTGACGCTGGTG GAGGCCACGATTTTTGGAATGG SEQ ID NO: 2762 GCACAGACTATTCACAGAGGTT TTATTGTACCGTTTGACTAC TCAGGGC SEQ ID NO: 3076 SEQ ID NO: 2919 AA GYYIH WINPDAGGTDYSQRFQG EATIFGMVIVPFDY SEQ ID NO: 1192 SEQ ID NO: 1349 SEQ ID NO: 1506 iPS:361268 5C2.014 NA GGCTACTATATCCAC TGGATCAACCCTGACGCTGGTG GAGGCCACGATTTTTGGAATGG SEQ ID NO: 2763 GCACAGACTATTCACAGAGGTT TTATTGTACCGTTTGACTAC TCAGGGC SEQ ID NO: 3077 SEQ ID NO: 2920 AA GYYIH WINPDAGGTDYSQRFQG EATIFGMVIVPFDY SEQ ID NO: 1193 SEQ ID NO: 1350 SEQ ID NO: 1507 iPS:359669 5C2.015 NA GGCTACTATATCCAC TGGATCAACCCTGACGCTGGTG GAGGCCACGATTTTTGGAATGG SEQ ID NO: 2764 GCACAGACTATTCACAGAGGTT TTATTGTACCGTTTGACTAC TCAGGGC SEQ ID NO: 3078 SEQ ID NO: 2921 AA GYYIH WINPDAGGTDYSQRFQG EATIFGMVIVPFDY SEQ ID NO: 1194 SEQ ID NO: 1351 SEQ ID NO: 1508 iPS:359678 5C2.016 NA GGCTACTATATCCAC TGGATCAACCCTGAAAGTGGTG GAGGCCACGATTTTTGGAATGG SEQ ID NO: 2765 GCACAGACTATTCACAGAGGTT TTATTGTACCGTTTGACTAC TCAGGGC SEQ ID NO: 3079 SEQ ID NO: 2922 AA GYYIH WINPESGGTDYSQRFQG EATIFGMVIVPFDY SEQ ID NO: 1195 SEQ ID NO: 1352 SEQ ID NO: 1509 iPS:361275 11C1.002 NA GGCTACTATATACAC TGGATCAGCCCTAACAGTGGTG GAGGCCACGATTTTTGGAATGC SEQ ID NO: 2766 AAACAAGCTATGCACAGAAGT TTATTGTACCATTTGACTAC TTCAGGAC SEQ ID NO: 3080 SEQ ID NO: 2923 AA GYYIH WISPNSGETSYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1196 SEQ ID NO: 1353 SEQ ID NO: 1510 iPS:361282 11C1.003 NA GGCTACTATATACAC TGGATCAGCCCTAACAGTGGTG GAGGCCACGATTTTTGGAATGC SEQ ID NO: 2767 ACACAAGCTATGCACAGAAGT TTATTGTACCATTTGACTAC TTCAGGAC SEQ ID NO: 3081 SEQ ID NO: 2924 AA GYYIH WISPNSGDTSYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1197 SEQ ID NO: 1354 SEQ ID NO: 1511 iPS:361289 11C1.004 NA GGCTACTATATACAC TGGATCAGCCCTAACAGTGGTG GAGGCCACGATTTTTGGAATGC SEQ ID NO: 2768 AAACAAGCTATGCACAGAAGT TTATTGTACCATTTGACTAC TTCAGGAC SEQ ID NO: 3082 SEQ ID NO: 2925 AA GYYIH WISPNSGETSYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1198 SEQ ID NO: 1355 SEQ ID NO: 1512 iPS:359712 11C1.005 NA GGCTACTATATACAC TGGATCAGCCCTAACAGTGGTG GAGGCCACGATTTTTGGAATGC SEQ ID NO: 2769 AAACAAGCTATGCACAGAAGT TTATTGTACCATTTGACTAC TTCAGGAC SEQ ID NO: 3083 SEQ ID NO: 2926 AA GYYIH WISPNSGETSYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1199 SEQ ID NO: 1356 SEQ ID NO: 1513 iPS:361293 11C1.006 NA GGCTACTATATACAC TGGATCAGCCCTAACAGTGGTG GAGGCCACGATTTTTGGAATGC SEQ ID NO: 2770 ACACAAGCTATGCACAGAAGT TTATTGTACCATTTGACTAC TTCAGGAC SEQ ID NO: 3084 SEQ ID NO: 2927 AA GYYIH WISPNSGDTSYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1200 SEQ ID NO: 1357 SEQ ID NO: 1514 iPS:361297 11C1.007 NA GGCTACTATATACAC TGGATCAGCCCTAACAGTGGTG GAGGCCACGATTTTTGGAATGC SEQ ID NO: 2771 AAACAAGCTATGCACAGAAGT TTATTGTACCATTTGACTAC TTCAGGAC SEQ ID NO: 3085 SEQ ID NO: 2928 AA GYYIH WISPNSGETSYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1201 SEQ ID NO: 1358 SEQ ID NO: 1515 iPS:361301 11C1.008 NA GGCTACTATATACAC TGGATCAGCCCTAACAGTGGTG GAGGCCACGATTTTTGGAATGC SEQ ID NO: 2772 ACACAAGCTATGCACAGAAGT TTATTGTACCATTTGACTAC TTCAGGAC SEQ ID NO: 3086 SEQ ID NO: 2929 AA GYYIH WISPNSGDTSYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1202 SEQ ID NO: 1359 SEQ ID NO: 1516 iPS:359703 11C1.009 NA GGCTACTATATACAC TGGATCAGCCCTAACAGTGGTG GAGGCCACGATTTTTGGAATGC SEQ ID NO: 2773 AAACAAGCTATGCACAGAAGT TTATTGTACCATTTGACTAC TTCAGGAC SEQ ID NO: 3087 SEQ ID NO: 2930 AA GYYIH WISPNSGETSYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1203 SEQ ID NO: 1360 SEQ ID NO: 1517 iPS:361305 11C1.010 NA GGCTACTATATACAC TGGATCAGCCCTAACAGTGGTG GAGGCCACGATTTTTGGAATGC SEQ ID NO: 2774 AAACAAGCTATGCACAGAAGT TTATTGTACCATTTGACTAC TTCAGGAC SEQ ID NO: 3088 SEQ ID NO: 2931 AA GYYIH WISPNSGETSYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1204 SEQ ID NO: 1361 SEQ ID NO: 1518 iPS:361312 13H12.002 NA GGCTACTATATCCAC TGGATCAACCCTGAAAGTGGTG GAGGCCACGATTTTTGGAATGG SEQ ID NO: 2775 GCACAGACTATTCACAGAGGTT TTATTGTACCGTTTGACTAC TCAGGGC SEQ ID NO: 3089 SEQ ID NO: 2932 AA GYYIH WINPESGGTDYSQRFQG EATIFGMVIVPFDY SEQ ID NO: 1205 SEQ ID NO: 1362 SEQ ID NO: 1519 iPS:359744 13H12.003 NA GGCTACTATATCCAC TGGATCAACCCTGAAAGTGGTG GAGGCCACGATTTTTGGAATGG SEQ ID NO: 2776 GCACAGACTATTCACAGAGGTT TTATTGTACCGTTTGACTAC TCAGGGC SEQ ID NO: 3090 SEQ ID NO: 2933 AA GYYIH WINPESGGTDYSQRFQG EATIFGMVIVPFDY SEQ ID NO: 1206 SEQ ID NO: 1363 SEQ ID NO: 1520 iPS:361319 13H12.004 NA GGCTACTATATCCAC TGGATCAACCCTGACAGTGGTG GAGGCCACGATTTTTGGAATGG SEQ ID NO: 2777 GCACAGACTATTCACAGAGGTT TTATTGTACCGTTTGACTAC TCAGGGC SEQ ID NO: 3091 SEQ ID NO: 2934 AA GYYIH WINPDSGGTDYSQRFQG EATIFGMVIVPFDY SEQ ID NO: 1207 SEQ ID NO: 1364 SEQ ID NO: 1521 iPS:359737 13H12.005 NA GGCTACTATATCCAC TGGATCAACCCTGAAAGTGGTG GAGGCCACGATTTTTGGAATGG SEQ ID NO: 2778 GCACAGACTATTCACAGAGGTT TTATTGTACCGTTTGACTAC TCAGGGC SEQ ID NO: 3092 SEQ ID NO: 2935 AA GYYIH WINPESGGTDYSQRFQG EATIFGMVIVPFDY SEQ ID NO: 1208 SEQ ID NO: 1365 SEQ ID NO: 1522 iPS:361326 13H12.006 NA GGCTACTATATCCAC TGGATCAACCCTGAAAGTGGTG GAGGCCACGATTTTTGGAATGG SEQ ID NO: 2779 GCACAGACTATTCACAGAGGTT TTATTGTACCGTTTGACTAC TCAGGGC SEQ ID NO: 3093 SEQ ID NO: 2936 AA GYYIH WINPESGGTDYSQRFQG EATIFGMVIVPFDY SEQ ID NO: 1209 SEQ ID NO: 1366 SEQ ID NO: 1523 iPS:361330 12H11.002 NA GGCTACTATATACAC TGGATAAGCCCTAACCAAGGT GAGGCCACGATTTTTGGAATGC SEQ ID NO: 2780 GAAACAAACTATGCACAGAAG TTATTGTACCATTTGACTAC TTTCAGGAC SEQ ID NO: 3094 SEQ ID NO: 2937 AA GYYIH WISPNQGETNYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1210 SEQ ID NO: 1367 SEQ ID NO: 1524 iPS:361337 12H11.003 NA GGCTACTATATACAC TGGATAAGCCCTAACCAAGGT GAGGCCACGATTTTTGGAATGC SEQ ID NO: 2781 GACACAAACTATGCACAGAAG TTATTGTACCATTTGACTAC TTTCAGGAC SEQ ID NO: 3095 SEQ ID NO: 2938 AA GYYIH WISPNQGDTNYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1211 SEQ ID NO: 1368 SEQ ID NO: 1525 iPS:361344 12H11.004 NA GGCTACTATATACAC TGGATAAGCCCTAACCAAGGT GAGGCCACGATTTTTGGAATGC SEQ ID NO: 2782 GAAACAAACTATGCACAGAAG TTATTGTACCATTTGACTAC TTTCAGGAC SEQ ID NO: 3096 SEQ ID NO: 2939 AA GYYIH WISPNQGETNYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1212 SEQ ID NO: 1369 SEQ ID NO: 1526 iPS:361351 12H11.005 NA GGCTACTATATACAC TGGATAAGCCCTAACAATGGTG GAGGCCACGATTTTTGGAATGC SEQ ID NO: 2783 AAACAAACTATGCACAGAAGT TTATTGTACCATTTGACTAC TTCAGGAC SEQ ID NO: 3097 SEQ ID NO: 2940 AA GYYIH WISPNNGETNYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1213 SEQ ID NO: 1370 SEQ ID NO: 1527 iPS:361358 12H11.006 NA GGCTACTATATACAC TGGATAAGCCCTAACAATGGTG GAGGCCACGATTTTTGGAATGC SEQ ID NO: 2784 ACACAAACTATGCACAGAAGT TTATTGTACCATTTGACTAC TTCAGGAC SEQ ID NO: 3098 SEQ ID NO: 2941 AA GYYIH WISPNNGDTNYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1214 SEQ ID NO: 1371 SEQ ID NO: 1528 iPS:361365 12H11.007 NA GGCTACTATATACAC TGGATAAGCCCTAACCAAGGT GAGGCCACGATTTTTGGAATGC SEQ ID NO: 2785 GACACAAACTATGCACAGAAG TTATTGTACCATTTGACTAC TTTCAGGAC SEQ ID NO: 3099 SEQ ID NO: 2942 AA GYYIH WISPNQGDTNYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1215 SEQ ID NO: 1372 SEQ ID NO: 1529 iPS:361372 12H11.008 NA GGCTACTATATACAC TGGATAAGCCCTAACAATGGTG GAGGCCACGATTTTTGGAATGC SEQ ID NO: 2786 AAACAAACTATGCACAGAAGT TTATTGTACCATTTGACTAC TTCAGGAC SEQ ID NO: 3100 SEQ ID NO: 2943 AA GYYIH WISPNNGETNYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1216 SEQ ID NO: 1373 SEQ ID NO: 1530 iPS:361379 12H11.009 NA GGCTACTATATACAC TGGATAAGCCCTAACCAAGGT GAGGCCACGATTTTTGGAATGC SEQ ID NO: 2787 GAAACAAACTATGCACAGAAG TTATTGTACCATTTGACTAC TTTCAGGAC SEQ ID NO: 3101 SEQ ID NO: 2944 AA GYYIH WISPNQGETNYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1217 SEQ ID NO: 1374 SEQ ID NO: 1531 iPS:361383 12H11.010 NA GGCTACTATATACAC TGGATAAGCCCTAACAATGGTG GAGGCCACGATTTTTGGAATGC SEQ ID NO: 2788 ACACAAACTATGCACAGAAGT TTATTGTACCATTTGACTAC TTCAGGAC SEQ ID NO: 3102 SEQ ID NO: 2945 AA GYYIH WISPNNGDTNYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1218 SEQ ID NO: 1375 SEQ ID NO: 1532 iPS:361387 12H11.011 NA GGCTACTATATACAC TGGATAAGCCCTAACCAAGGT GAGGCCACGATTTTTGGAATGC SEQ ID NO: 2789 GACACAAACTATGCACAGAAG TTATTGTACCATTTGACTAC TTTCAGGAC SEQ ID NO: 3103 SEQ ID NO: 2946 AA GYYIH WISPNQGDTNYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1219 SEQ ID NO: 1376 SEQ ID NO: 1533 iPS:361391 12H11.012 NA GGCTACTATATACAC TGGATAAGCCCTAACAATGGTG GAGGCCACGATTTTTGGAATGC SEQ ID NO: 2790 AAACAAACTATGCACAGAAGT TTATTGTACCATTTGACTAC TTCAGGAC SEQ ID NO: 3104 SEQ ID NO: 2947 AA GYYIH WISPNNGETNYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1220 SEQ ID NO: 1377 SEQ ID NO: 1534 iPS:361395 12H11.013 NA GGCTACTATATACAC TGGATAAGCCCTAACCAAGGT GAGGCCACGATTTTTGGAATGC SEQ ID NO: 2791 GAAACAAACTATGCACAGAAG TTATTGTACCATTTGACTAC TTTCAGGAC SEQ ID NO: 3105 SEQ ID NO: 2948 AA GYYIH WISPNQGETNYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1221 SEQ ID NO: 1378 SEQ ID NO: 1535 iPS:361402 12H11.014 NA GGCTACTATATACAC TGGATAAGCCCTAACCAAGGT GAGGCCACGATTTTTGGAATGC SEQ ID NO: 2792 GAAACAAACTATGCACAGAAG TTATTGTACCATTTGACTAC TTTCAGGAC SEQ ID NO: 3106 SEQ ID NO: 2949 AA GYYIH WISPNQGETNYAQKFQD EATIFGMLIVPFDY SEQ ID NO: 1222 SEQ ID NO: 1379 SEQ ID NO: 1536 iPS:361406 2C2.005.001 NA GGCTACTATATGCAT TGGATCAACCCTAACAGTGGTG GGGGGGGATTACGTTTGGGGG SEQ ID NO: 2793 GCACAAACTATGCACAGAAGT ACTTATCGGCCTCACTACTACT TTCAGGGC ACGGTATGGACGTC SEQ ID NO: 2950 SEQ ID NO: 3107 AA GYYMH WINPNSGGTNYAQKFQG GGDYVWGTYRPHYYYGMDV SEQ ID NO: 1223 SEQ ID NO: 1380 SEQ ID NO: 1537 iPS:361412 2C2.005.002 NA GGCTACTATATGCAT TGGATCAACCCTAACAGTGGTG GGGGGGGATTACGTTTGGGGG SEQ ID NO: 2794 GCACAAACTATGCACAGAAGT ACTTATCGGCCTCACTACTACT TTCAGGGC ACGGTATGGACGTC SEQ ID NO: 2951 SEQ ID NO: 3108 AA GYYMH WINPNSGGTNYAQKFQG GGDYVWGTYRPHYYYGMDV SEQ ID NO: 1224 SEQ ID NO: 1381 SEQ ID NO: 1538 iPS:361418 2C2.005.003 NA GGCTACTATATGCAT TGGATCAACCCTAACAGTGGTG GGGGGGGATTACGTTTGGGGG SEQ ID NO: 2795 GCACAAACTATGCACAGAAGT ACTTATCGGCCTCACTACTACT TTCAGGGC ACGGTATGGACGTC SEQ ID NO: 2952 SEQ ID NO: 3109 AA GYYMH WINPNSGGTNYAQKFQG GGDYVWGTYRPHYYYGMDV SEQ ID NO: 1225 SEQ ID NO: 1382 SEQ ID NO: 1539 iPS:361424 2C2.005.004 NA GGCTACTATATGCAT TGGATCAACCCTAACAGTGGTG GGGGGGGATTACGTTTGGGGG SEQ ID NO: 2796 GCACAAACTATGCACAGAAGT ACTTATCGGCCTCACTACTACT TTCAGGGC ACGGTATGGACGTC SEQ ID NO: 2953 SEQ ID NO: 3110 AA GYYMH WINPNSGGTNYAQKFQG GGDYVWGTYRPHYYYGMDV SEQ ID NO: 1226 SEQ ID NO: 1383 SEQ ID NO: 1540 iPS:361430 2C2.005.005 NA GGCTACTATATGCAT TGGATCAACCCTAACAGTGGTG GGGGGGGATTACGTTTGGGGG SEQ ID NO: 2797 GCACAAACTATGCACAGAAGT ACTTATCGGCCTCACTACTACT TTCAGGGC ACGGTATGGACGTC SEQ ID NO: 2954 SEQ ID NO: 3111 AA GYYMH WINPNSGGTNYAQKFQG GGDYVWGTYRPHYYYGMDV SEQ ID NO: 1227 SEQ ID NO: 1384 SEQ ID NO: 1541 iPS:361436 2C2.005.006 NA GGCTACTATATGCAT TGGATCAACCCTAACAGTGGTG GGGGGGGATTACGTTTGGGGG SEQ ID NO: 2798 GCACAAACTATGCACAGAAGT ACTTATCGGCCTCACTACTACT TTCAGGGC ACGGTATGGACGTC SEQ ID NO: 2955 SEQ ID NO: 3112 AA GYYMH WINPNSGGTNYAQKFQG GGDYVWGTYRPHYYYGMDV SEQ ID NO: 1228 SEQ ID NO: 1385 SEQ ID NO: 1542 iPS:361442 2C2.005.007 NA GGCTACTATATGCAT TGGATCAACCCTAACAGTGGTG GGGGGGGATTACGTTTGGGGG SEQ ID NO: 2799 GCACAAACTATGCACAGAAGT ACTTATCGGCCTCACTACTACT TTCAGGGC ACGGTATGGACGTC SEQ ID NO: 2956 SEQ ID NO: 3113 AA GYYMH WINPNSGGTNYAQKFQG GGDYVWGTYRPHYYYGMDV SEQ ID NO: 1229 SEQ ID NO: 1386 SEQ ID NO: 1543 iPS:361448 2C2.005.008 NA GGCTACTATATGCAT TGGATCAACCCTAACAGTGGTG GGGGGGGATTACGTTTGGGGG SEQ ID NO: 2800 GCACAAACTATGCACAGAAGT ACTTATCGGCCTCACTACTACT TTCAGGGC ACGGTATGGACGTC SEQ ID NO: 2957 SEQ ID NO: 3114 AA GYYMH WINPNSGGTNYAQKFQG GGDYVWGTYRPHYYYGMDV SEQ ID NO: 1230 SEQ ID NO: 1387 SEQ ID NO: 1544 iPS:361454 2C2.005.009 NA GGCTACTATATGCAT TGGATCAACCCTAACAGTGGTG GGGGGGGATTACGTTTGGGGG SEQ ID NO: 2801 GCACAAACTATGCACAGAAGT ACTTATCGGCCTCACTACTACT TTCAGGGC ACGGTATGGACGTC SEQ ID NO: 2958 SEQ ID NO: 3115 AA GYYMH WINPNSGGTNYAQKFQG GGDYVWGTYRPHYYYGMDV SEQ ID NO: 1231 SEQ ID NO: 1388 SEQ ID NO: 1545 iPS:361460 2C2.005.010 NA GGCTACTATATGCAT TGGATCAACCCTAACAGTGGTG GGGGGGGATTACGTTTGGGGG SEQ ID NO: 2802 GCACAAACTATGCACAGAAGT ACTTATCGGCCTCACTACTACT TTCAGGGC ACGGTATGGACGTC SEQ ID NO: 2959 SEQ ID NO: 3116 AA GYYMH WINPNSGGTNYAQKFQG GGDYVWGTYRPHYYYGMDV SEQ ID NO: 1232 SEQ ID NO: 1389 SEQ ID NO: 1546 iPS:361466 2C2.005.011 NA GGCTACTATATGCAT TGGATCAACCCTAACAGTGGTG GGGGGGGATTACGTTTGGGGG SEQ ID NO: 2803 GCACAAACTATGCACAGAAGT ACTTATCGGCCTCACTACTACT TTCAGGGC ACGGTATGGACGTC SEQ ID NO: 2960 SEQ ID NO: 3117 AA GYYMH WINPNSGGTNYAQKFQG GGDYVWGTYRPHYYYGMDV SEQ ID NO: 1233 SEQ ID NO: 1390 SEQ ID NO: 1547 iPS:361472 2C2.005.012 NA GGCTACTATATGCAT TGGATCAACCCTAACAGTGGTG GGGGGGGATTACGTTTGGGGG SEQ ID NO: 2804 GCACAAACTATGCACAGAAGT ACTTATCGGCCTCACTACTACT TTCAGGGC ACGGTATGGACGTC SEQ ID NO: 2961 SEQ ID NO: 3118 AA GYYMH WINPNSGGTNYAQKFQG GGDYVWGTYRPHYYYGMDV SEQ ID NO: 1234 SEQ ID NO: 1391 SEQ ID NO: 1548 iPS:361478 2C2.005.013 NA GGCTACTATATGCAT TGGATCAACCCTAACAGTGGTG GGGGGGGATTACGTTTTCGGGA SEQ ID NO: 2805 GCACAAACTATGCACAGAAGT CTTATCGGCCTCACTACTACTA TTCAGGGC CGGTATGGACGTC SEQ ID NO: 2962 SEQ ID NO: 3119 AA GYYMH WINPNSGGTNYAQKFQG GGDYVFGTYRPHYYYGMDV SEQ ID NO: 1235 SEQ ID NO: 1392 SEQ ID NO: 1549 iPS:361485 2C2.005.014 NA GGCTACTATATGCAT TGGATCAACCCTAACAGTGGTG GGGGGGGATTACGTTTTCGGGA SEQ ID NO: 2806 GCACAAACTATGCACAGAAGT CTTATCGGCCTCACTACTACTA TTCAGGGC CGGTATGGACGTC SEQ ID NO: 2963 SEQ ID NO: 3120 AA GYYMH WINPNSGGTNYAQKFQG GGDYVFGTYRPHYYYGMDV SEQ ID NO: 1236 SEQ ID NO: 1393 SEQ ID NO: 1550 iPS:361845 18F2.013 NA AACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA GATAGGACGATCTTTGGAGTGG SEQ ID NO: 2807 ATGAAAACTATGCAGACGCCG TCTTGGGGGACTAC TGAAGGGC SEQ ID NO: 3121 SEQ ID NO: 2964 AA NFGMH VIWYDASNENYADAVKG DRTIFGVVLGDY SEQ ID NO: 1237 SEQ ID NO: 1394 SEQ ID NO: 1551 iPS:361851 6H1.009 NA TACTTTGGCATGCAC GTTATATGGTATGATGCAAGTA GATAGGACGATTTTTGGAGTGC SEQ ID NO: 2808 ATAAATACTATGCAGACGCCGT TCTTGGGGGACTAC GAAGGGC SEQ ID NO: 3122 SEQ ID NO: 2965 AA YFGMH VIWYDASNKYYADAVKG DRTIFGVLLGDY SEQ ID NO: 1238 SEQ ID NO: 1395 SEQ ID NO: 1552 iPS:361855 2C2.005.015 NA GGCTACTATATGCAT TGGATCAACCCTAACAGTGGTG GGGGGGGATTACGTTTGGGGG SEQ ID NO: 2809 GCACAAACTATGCACAGAAGT ACTTATCGGCCTCACTACTACT TTCAGGGC ACGGTATGGACGTC SEQ ID NO: 2966 SEQ ID NO: 3123 AA GYYMH WINPNSGGTNYAQKFQG GGDYVWGTYRPHYYYGMDV SEQ ID NO: 1239 SEQ ID NO: 1396 SEQ ID NO: 1553 iPS:336067 5G12.006 NA AGCTATGGCATACAC GTTATATGGTATGATGGAAGTA GGAAAAGTGGCTGGTATGCCT SEQ ID NO: 2810 ATAAGTTCCATGCAGACTCCGT GAAGCTTTTGAAATC GAAGGGC SEQ ID NO: 3124 SEQ ID NO: 2967 AA SYGIH VIWYDGSNKFHADSVKG GKVAGMPEAFEI SEQ ID NO: 1240 SEQ ID NO: 1397 SEQ ID NO: 1554 iPS:336169 17B11.002 NA AGTTATGATATCAAC TGGATGAACCCTAACAGTGGTA GGGGGTGATTACGTTTGGGGG SEQ ID NO: 2811 ACACAGGCTATGCACAGAAGT AGTTATCGTCCCTACTACTACT TCCAGGGC ACTACGGTATGGACGTC SEQ ID NO: 2968 SEQ ID NO: 3125 AA SYDIN WMNPNSGNTGYAQKFQG GGDYVWGSYRPYYYYYGMDV SEQ ID NO: 1241 SEQ ID NO: 1398 SEQ ID NO: 1555 iPS:361127 5G12.006.001 NA AGCTATGGCATACAC GTTATATGGTATGATGCAAGTA GGAAAAGTGGCTGGTATGCCT SEQ ID NO: 2812 ATAAGTTCCATGCAGACGCCGT GAAGCTTTTGAAATC GAAGGGC SEQ ID NO: 3126 SEQ ID NO: 2969 AA SYGIH VIWYDASNKFHADAVKG GKVAGMPEAFEI SEQ ID NO: 1242 SEQ ID NO: 1399 SEQ ID NO: 1556 iPS:361136 5G12.006.002 NA AGCTATGGCATACAC GTTATATGGTATGATGCAAGTA GGAAAAGTGGCTGGTATGCCT SEQ ID NO: 2813 ATAAGTTCCATGCAGACGCCGT GAAGCTTTTGAAATC GAAGGGC SEQ ID NO: 3127 SEQ ID NO: 2970 AA SYGIH VIWYDASNKFHADAVKG GKVAGMPEAFEI SEQ ID NO: 1243 SEQ ID NO: 1400 SEQ ID NO: 1557 iPS:361140 5G12.006.003 NA AGCTATGGCATACAC GTTATATGGTATGATGCAAGTA GGAAAAGTGGCTGGTATGCCT SEQ ID NO: 2814 ATAAGTTCCATGCAGACGCCGT GAAGCTTTTGAAATC GAAGGGC SEQ ID NO: 3128 SEQ ID NO: 2971 AA SYGIH VIWYDASNKFHADAVKG GKVAGMPEAFEI SEQ ID NO: 1244 SEQ ID NO: 1401 SEQ ID NO: 1558 iPS:359919 5G12.006.004 NA AGCTATGGCATACAC GTTATATGGTATGATGCAAGTA GGAAAAGTGGCTGGTATGCCT SEQ ID NO: 2815 ATAAGTTCCATGCAGACGCCGT GAAGCTTTTGAAATC GAAGGGC SEQ ID NO: 3129 SEQ ID NO: 2972 AA SYGIH VIWYDASNKFHADAVKG GKVAGMPEAFEI SEQ ID NO: 1245 SEQ ID NO: 1402 SEQ ID NO: 1559 iPS:361144 5G12.006.005 AGCTATGGCATACAC GTTATATGGTATGATGCAAGTA GGAAAAGTGGCTGGTATGCCT SEQ ID NO: 2816 ATAAGTTCCATGCAGACTCCGT GAAGCTTTTGAAATC GAAGGGC SEQ ID NO: 3130 SEQ ID NO: 2973 AA SYGIH VIWYDASNKFHADSVKG GKVAGMPEAFEI SEQ ID NO: 1246 SEQ ID NO: 1403 SEQ ID NO: 1560 iPS:361151 5G12.006.006 NA AGCTATGGCATACAC GTTATATGGTATGATGGAAGTA GGAAAAGTGGCTGGTATGCCT SEQ ID NO: 2817 ATAAGTTCCATGCAGACGCCGT GAAGCTTTTGAAATC GAAGGGC SEQ ID NO: 3131 SEQ ID NO: 2974 AA SYGIH VIWYDGSNKFHADAVKG GKVAGMPEAFEI SEQ ID NO: 1247 SEQ ID NO: 1404 SEQ ID NO: 1561 iPS:361491 17B11.002.001 NA AGTTATGATATCAAC TGGATGAACCCTAACAGTGGTG GGGGGTGATTACGTTTGGGGG SEQ ID NO: 2818 GCACAGGCTATGCACAGAAGT AGTTATCGTCCCTACTACTACT TCCAGGGC ACTACGGTATGGACGTC SEQ ID NO: 2975 SEQ ID NO: 3132 AA SYDIN WMNPNSGGTGYAQKFQG GGDYVWGSYRPYYYYYGMDV SEQ ID NO: 1248 SEQ ID NO: 1405 SEQ ID NO: 1562 iPS:361499 17B11.002.002 NA AGTTATGATATCAAC TGGATGAACCCTAACAGTGGTA GGGGGTGATTACGTTTGGGGG SEQ ID NO: 2819 ACACAGGCTATGCACAGAAGT AGTTATCGTCCCTACTACTACT TCCAGGGC ACTACGGTATGGACGTC SEQ ID NO: 2976 SEQ ID NO: 3133 AA SYDIN WMNPNSGNTGYAQKFQG GGDYVWGSYRPYYYYYGMDV SEQ ID NO: 1249 SEQ ID NO: 1406 SEQ ID NO: 1563 iPS:361503 17B11.002.003 NA AGTTATGATATCAAC TGGATGAACCCTAACAGTGGTG GGGGGTGATTACGTTTGGGGG SEQ ID NO: 2820 GCACAGGCTATGCACAGAAGT AGTTATCGTCCCTACTACTACT TCCAGGGC ACTACGGTATGGACGTC SEQ ID NO: 2977 SEQ ID NO: 3134 AA SYDIN WMNPNSGGTGYAQKFQG GGDYVWGSYRPYYYYYGMDV SEQ ID NO: 1250 SEQ ID NO: 1407 SEQ ID NO: 1564 iPS:361507 17B11.002.004 NA AGTTATGATATCAAC TGGATGAACCCTAACAGTGGTG GGGGGTGATTACGTTTGGGGG SEQ ID NO: 2821 GCACAGGCTATGCACAGAAGT AGTTATCGTCCCTACTACTACT TCCAGGGC ACTACGGTATGGACGTC SEQ ID NO: 2978 SEQ ID NO: 3135 AA SYDIN WMNPNSGGTGYAQKFQG GGDYVWGSYRPYYYYYGMDV SEQ ID NO: 1251 SEQ ID NO: 1408 SEQ ID NO: 1565 iPS:361514 17B11.002.005 NA AGTTATGATATCAAC TGGATGAACCCTAACAGTGGTG GGGGGTGATTACGTTTGGGGG SEQ ID NO: 2822 GCACAGGCTATGCACAGAAGT AGTTATCGTCCCTACTACTACT TCCAGGGC ACTACGGTATGGACGTC SEQ ID NO: 2979 SEQ ID NO: 3136 AA SYDIN WMNPNSGGTGYAQKFQG GGDYVWGSYRPYYYYYGMDV SEQ ID NO: 1252 SEQ ID NO: 1409 SEQ ID NO: 1566 iPS:360582 17B11.002.006 NA AGTTATGATATCAAC TGGATGAACCCTAACAGTGGTA GGGGGTGATTACGTTTGGGGG SEQ ID NO: 2823 ACACAGGCTATGCACAGAAGT AGTTATCGTCCCTACTACTACT TCCAGGGC ACTACGGTATGGACGTC SEQ ID NO: 2980 SEQ ID NO: 3137 AA SYDIN WMNPNSGNTGYAQKFQG GGDYVWGSYRPYYYYYGMDV SEQ ID NO: 1253 SEQ ID NO: 1410 SEQ ID NO: 1567 iPS:361518 17B11.002.007 NA AGTTATGATATCAAC TGGATGAACCCTAACAGTGGTG GGGGGTGATTACGTTTTCGGGA SEQ ID NO: 2824 GCACAGGCTATGCACAGAAGT GTTATCGTCCCTACTACTACTA TCCAGGGC CTACGGTATGGACGTC SEQ ID NO: 2981 SEQ ID NO: 3138 AA SYDIN WMNPNSGGTGYAQKFQG GGDYVFGSYRPYYYYYGMDV SEQ ID NO: 1254 SEQ ID NO: 1411 SEQ ID NO: 1568 iPS:360570 17B11.002.008 NA AGTTATGATATCAAC TGGATGAACCCTAACAGTGGTG GGGGGTGATTACGTTTTCGGGA SEQ ID NO: 2825 GCACAGGCTATGCACAGAAGT GTTATCGTCCCTACTACTACTA TCCAGGGC CTACGGTATGGACGTC SEQ ID NO: 2982 SEQ ID NO: 3139 AA SYDIN WMNPNSGGTGYAQKFQG GGDYVFGSYRPYYYYYGMDV SEQ ID NO: 1255 SEQ ID NO: 1412 SEQ ID NO: 1569 iPS:362051 5G12.005.001 NA AGCTATGGCATACAC GTTATATGGTATGATGCAAGTA GGAAAAGTGGCTGGTATGCCT SEQ ID NO: 2826 ATAAGTTCCATGCAGACGCCGT GAAGCTTTTGAAATC GAAGGGC SEQ ID NO: 3140 SEQ ID NO: 2983 AA SYGIH VIWYDASNKFHADAVKG GKVAGMPEAFEI SEQ ID NO: 1256 SEQ ID NO: 1413 SEQ ID NO: 1570

TABLE 5 Exemplary Light and Heavy Chain Nucleic Acid (“NA”) and Amino Acid (“AA”) Sequences iPS # Ab Type LC HC iPS:336175 2C2.005 NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGTAGCTCCAACATCGGAAGTAATACTG AAGGCTTCCGGATACACCTTCACCGGCTACTAT TAAACTGGTACCAGCACCTCCCAGGAACGGCCC ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATCTATACTAATAATCAGCGGC CTTGAGTGGATGGGATGGATCAACCCTAACAGT CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GGTGGCACAAACTATGCACAGAAGTTTCAGGGC GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG AGGGTCACCATGACCAGGGACACGTCCATCAGT CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT CAACATTCGATGACAGCCTGAATGGTCCGGTAT GACGACACGGCCGTGTATTACTGTGCGAGAGGG TCGGCGGAGGGACCAAGCTGACCGTCCTAGGTC GGGGATTACGTTTGGGGGACTTATCGGCCTCAC AGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCC TACTACTACGGTATGGACGTCTGGGGCCAAGGG GCCCTCCTCTGAGGAGCTTCAAGCCAACAAGGC ACCACGGTCACCGTCTCCTCAGCCTCCACCAAG CACACTGGTGTGTCTCATAAGTGACTTCTACCCG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCA GGAGCCGTGACAGTGGCCTGGAAGGCAGATAG AGAGCACCTCTGGGGGCACAGCGGCCCTGGGCT CAGCCCCGTCAAGGCGGGAGTGGAGACCACCAC GCCTGGTCAAGGACTACTTCCCCGAACCGGTGA ACCCTCCAAACAAAGCAACAACAAGTACGCGGC CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCG CAGCAGCTATCTGAGCCTGACGCCTGAGCAGTG GCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC GAAGTCCCACAGAAGCTACAGCTGCCAGGTCAC AGGACTCTACTCCCTCAGCAGCGTGGTGACCGT GCATGAAGGGAGCACCGTGGAGAAGACAGTGG GCCCTCCAGCAGCTTGGGCACCCAGACCTACAT CCCCTACAGAATGTTCA CTGCAACGTGAATCACAAGCCCAGCAACACCAA SEQ ID NO: 1885 GGTGGACAAGAAAGTTGAGCCCAAATCTTGTGA CAAAACTCACACATGCCCACCGTGCCCAGCACC TGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTC CCCCCAAAACCCAAGGACACCCTCATGATCTCC CGGACCCCTGAGGTCACATGCGTGGTGGTGGAC GTGAGCCACGAAGACCCTGAGGTCAAGTTCAAC TGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGTGTGAGGAGCAGTACGGCAG CACGTACCGTTGTGTCAGCGTCCTCACCGTCCTG CACCAGGACTGGCTGAATGGCAAGGAGTACAA GTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACCACAGGTGTACACCCTGCCCCC ATCCCGGGAGGAGATGACCAAGAACCAGGTCA GCCTGACCTGCCTGGTCAAAGGCTTCTATCCCA GCGACATCGCCGTGGAGTGGGAGAGCAATGGG CAGCCGGAGAACAACTACAAGACCACGCCTCCC GTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAG CAGGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCTCTGCACAACCACTACACGCAGAAGAGC CTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2042 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNW QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ ASLAISGLQSEDEADYFCATFDDSLNGPVFGGGTK GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG LTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISD GDYVWGTYRPHYYYGMDVWGQGTTVTVSSAST FYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKY KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT AASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTV VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS APTECS SSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH SEQ ID NO: 315 TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEV TCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKN QVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPP VLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO: 472 iPS:335914 4B1 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGGAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACTCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAATA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCACATGAACAGCCTGAGAGTCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT CGGACACGGCTGTGTATTATTGTGCGCGAGATG GGGACCAAAGTGGATATCAAACGAACGGTGGCT GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1886 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2043 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM QQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTEFT HWVRQAPGKGLEWVAVIWYDGSNENYADSVKG LTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDIKR RFTISRDNSKNTLYLHMNSLRVADTAVYYCARDG TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS KVQWKVDNALQSGNSQESVTEQDSKDSTYSLSST SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS LTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN EC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 316 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 473 iPS:335938 6H1 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGGAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATAAATACTATGCAGACTCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGGACCAAAGTGGATATCAAACGAACGGTGGCT GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1887 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2044 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM QQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTEFT HWVRQAPGKGLEWVAVIWYDGSNKYYADSVKG LTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDIKR RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA TIFGVLLGDYWGQGTLVTVSSASTKGPSVFPLAPS KVQWKVDNALQSGNSQESVTEQDSKDSTYSLSST SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS LTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN EC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 317 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 474 iPS:335941 2F11 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTACGATGCATCCAATTTGGAAA CTGGAGTGGGTGGCAGTTATATGGTATGATGGA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT AGTAATAAATACTATGCAGACTCCGTGAAGGGC CTGGGACAGATTTTAGTTTCACCATCAGCAGCCT CGATTCACCATCTCCAGCGACAATTCCAAGAAC GCAGCCTGAAGATATTGCAACATATTACTGTCA ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC ACAGTATGATATTCTCCTCACTTTCGGCGGAGG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GACCAAGGTGGAGATCAAGCGAACGGTGGCTG AGGACGATTTTTGGAGTGGTTCTTGACTACTGG CACCATCTGTCTTCATCTTCCCGCCATCTGATGA GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC GCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGC TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA CTGCTGAATAACTTCTATCCCAGAGAGGCCAAA CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG GTACAGTGGAAGGTGGATAACGCCCTCCAATCG GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC GGTAACTCCCAGGAGAGTGTCACAGAGCAGGAC GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC AGCAAGGACAGCACCTACAGCCTCAGCAGCACC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC CTGACGCTGAGCAAAGCAGACTACGAGAAACA CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC CAAAGTCTACGCCTGCGAAGTCACCCATCAGGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CCTGAGCTCGCCCGTCACAAAGAGCTTCAACAG CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1888 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2045 AA DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD HWVRQAPGKGLEWVAVIWYDGSNKYYADSVKG FSFTISSLQPEDIATYYCQQYDILLTFGGGTKVEI RFTISSDNSKNTLYLQMNSLRAEDTAVYYCARDR KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYP TIFGVVLDYWGQGTLVTVSSASTKGPSVFPLAPSS REAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV GEC NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG SEQ ID NO: 318 GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 475 iPS:335970 5C2 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT CTTGAGTGGATGGGGTGGATCAACCCTGACAGT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA AGGTTCACCATGACCAGGGACACGTCCATCAGC CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG ACAGCCTACATGGAACTGAACAGGCTGAGATCT TGGCAGTTTTTTACTGTCAACAATATTATAGTAC GACGACACGGCCGTGTATTACTGTGCGAGAGAG TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AATCAAACGAACGGTGGCTGCACCATCTGTCTT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CATCTTCCCGCCATCTGATGAGCAGTTGAAATCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC GGAACTGCCTCTGTTGTGTGCCTGCTGAATAACT CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TCTATCCCAGAGAGGCCAAAGTACAGTGGAAGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA TGGATAACGCCCTCCAATCGGGTAACTCCCAGG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGAGTGTCACAGAGCAGGACAGCAAGGACAGC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC ACCTACAGCCTCAGCAGCACCCTGACGCTGAGC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AAAGCAGACTACGAGAAACACAAAGTCTACGC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCC GGCACCCAGACCTACATCTGCAACGTGAATCAC CGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1889 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2046 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPDSGGTDYSQRFQGR GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ FTMTRDTSISTAYMELNRLRSDDTAVYYCAREATI GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL FGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS NNFYPREAKVQWKVDNALQSGNSQESVTEQDSK SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS DSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSP GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VTKSFNRGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 319 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 476 iPS:335978 13H12 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGA AAACCAGGACATCCTCCTAAGCTGCTCATTTACT CTTGAGTGGATGGGGTGGATCAACCCTGACAGT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA AGGTTCACCATGACCAGGGACACGTCCATCAGC CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG ACAGCCTACATGGAACTGAGCAGGCTGAGATCT TGGCAGTTTTTTACTGTCAACAATATTATAGTAC GACGACACGGCCGTGTATTACTGTGCGAGAGAG TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AATCAAACGAACGGTGGCTGCACCATCTGTCTT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CATCTTCCCGCCATCTGATGAGCAGTTGAAATCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC GGAACTGCCTCTGTTGTGTGCCTGCTGAATAACT CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TCTATCCCAGAGAGGCCAAAGTACAGTGGAAGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA TGGATAACGCCCTCCAATCGGGTAACTCCCAGG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGAGTGTCACAGAGCAGGACAGCAAGGACAGC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC ACCTACAGCCTCAGCAGCACCCTGACGCTGAGC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AAAGCAGACTACGAGAAACACAAAGTCTACGC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCC GGCACCCAGACCTACATCTGCAACGTGAATCAC CGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1890 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2047 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQKPGHPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPDSGGTDYSQRFQGR GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ FTMTRDTSISTAYMELSRLRSDDTAVYYCAREATI GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL FGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS NNFYPREAKVQWKVDNALQSGNSQESVTEQDSK SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS DSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSP GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VTKSFNRGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 320 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 477 iPS:335986 11C1 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTACAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAACAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGTGTGGATGGGGTGGATCAGCCCTAACAGT TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC GGTGACACAAGCTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTTCTGTACGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGAACGGTGGCTGCACCATCTGTCT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA GTGGATAACGCCCTCCAATCGGGTAACTCCCAG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC GAGAGTGTCACAGAGCAGGACAGCAAGGACAG AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC CACCTACAGCCTCAGCAGCACCCTGACGCTGAG GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC CAAAGCAGACTACGAGAAACACAAAGTCTACG AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC GGCACCCAGACCTACATCTGCAACGTGAATCAC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1891 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2048 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG HWVRQAPGQGLVWMGWISPNSGDTSYAQKFQDR SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF VTMTRDTSISTAYMELSRLRSDDTAVYFCTREATI GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC FGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS LLNNFYPREAKVQWKVDNALQSGNSQESVTEQDS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS KDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN PVTKSFNRGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 321 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 478 iPS:335994 12H11 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAGCAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGAGTGGATGGGGTGGATAAGCCCTAACAAT TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC GGTGACACAAACTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTACTGTACGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGAACGGTGGCTGCACCATCTGTCT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA GTGGATAACGCCCTCCAATCGGGTAACTCCCAG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC GAGAGTGTCACAGAGCAGGACAGCAAGGACAG AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC CACCTACAGCCTCAGCAGCACCCTGACGCTGAG GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC CAAAGCAGACTACGAGAAACACAAAGTCTACG AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC GGCACCCAGACCTACATCTGCAACGTGAATCAC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1892 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2049 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG HWVRQAPGQGLEWMGWISPNNGDTNYAQKFQD SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF RVTMTRDTSISTAYMELSRLRSDDTAVYYCTREA GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC TIFGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLA LLNNFYPREAKVQWKVDNALQSGNSQESVTEQDS PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT KDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSS SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC PVTKSFNRGEC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL SEQ ID NO: 322 LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK SEQ ID NO: 479 iPS:336024 18E3 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG CAGGTGCAGTTGCAGGAGTCGGGCCCAGGACTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GTGAAGCCTTCACAGACCCTGTCCCTCACCTGC GCAGGGCCAGTCAGAGTATTAGTTACAGTTACT ACTGTCTCTGGTGACTCCATCAGCAGTGGTGGTT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC ACTACTGGAGCTGGATCCGCCAGCACCCAGGGA CCCGGCTCCTCATCTATGGTGCATCCAGCAGGG AGGGCCTGGAGTGGATTGGGTACATCTATTACA CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GTGGGAGCACCTACTACAACCCGTCCCTCAAGA GGTCTGGGACAGACTTCACTCTCACCATCAGCA GTCGAGTTACCATATCAGTAGACACGTCTAAGA GACAGGAGCCTGATGATTTTGCAGTGTATTACT ACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGC GTCAGCAGTATGGTAGTTCACCGCTCACTTTCGG CGCGGACACGGCCGTGTATTACTGTGCGAGAGA CGGAGGGACCAAGGTGGAGATCAAACGAACGG TCGTATTACGATTTTTGGAGTGGTTATGGGGGGC TGGCTGCACCATCTGTCTTCATCTTCCCGCCATC GGTATGGACGTCTGGGGCCAAGGGACCACGGTC TGATGAGCAGTTGAAATCTGGAACTGCCTCTGT ACCGTCTCCTCAGCCTCCACCAAGGGCCCATCG TGTGTGCCTGCTGAATAACTTCTATCCCAGAGA GTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCT GGCCAAAGTACAGTGGAAGGTGGATAACGCCCT CTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCA CCAATCGGGTAACTCCCAGGAGAGTGTCACAGA AGGACTACTTCCCCGAACCGGTGACGGTGTCGT GCAGGACAGCAAGGACAGCACCTACAGCCTCA GGAACTCAGGCGCCCTGACCAGCGGCGTGCACA GCAGCACCCTGACGCTGAGCAAAGCAGACTACG CCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTA AGAAACACAAAGTCTACGCCTGCGAAGTCACCC CTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAG ATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCT CAGCTTGGGCACCCAGACCTACATCTGCAACGT TCAACAGGGGAGAGTGT GAATCACAAGCCCAGCAACACCAAGGTGGACA SEQ ID NO: 1893 AGAAAGTTGAGCCCAAATCTTGTGACAAAACTC ACACATGCCCACCGTGCCCAGCACCTGAACTCC TGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAA ACCCAAGGACACCCTCATGATCTCCCGGACCCC TGAGGTCACATGCGTGGTGGTGGACGTGAGCCA CGAAGACCCTGAGGTCAAGTTCAACTGGTACGT GGACGGCGTGGAGGTGCATAATGCCAAGACAA AGCCGTGTGAGGAGCAGTACGGCAGCACGTACC GTTGTGTCAGCGTCCTCACCGTCCTGCACCAGG ACTGGCTGAATGGCAAGGAGTACAAGTGCAAG GTCTCCAACAAAGCCCTCCCAGCCCCCATCGAG AAAACCATCTCCAAAGCCAAAGGGCAGCCCCGA GAACCACAGGTGTACACCCTGCCCCCATCCCGG GAGGAGATGACCAAGAACCAGGTCAGCCTGAC CTGCCTGGTCAAAGGCTTCTATCCCAGCGACAT CGCCGTGGAGTGGGAGAGCAATGGGCAGCCGG AGAACAACTACAAGACCACGCCTCCCGTGCTGG ACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCT CACCGTGGACAAGAGCAGGTGGCAGCAGGGGA ACGTCTTCTCATGCTCCGTGATGCATGAGGCTCT GCACAACCACTACACGCAGAAGAGCCTCTCCCT GTCTCCGGGTAAA SEQ ID NO: 2050 AA EIVLTQSPGTLSLSPGERATLSCRASQSISYSYLAW QVQLQESGPGLVKPSQTLSLTCTVSGDSISSGGYY YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF WSWIRQHPGKGLEWIGYIYYSGSTYYNPSLKSRVT TLTISRQEPDDFAVYYCQQYGSSPLTFGGGTKVEI ISVDTSKNQFSLKLSSVTAADTAVYYCARDRITIFG KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR VVMGGGMDVWGQGTTVTVSSASTKGPSVFPLAP EAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS SSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN RGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 323 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 480 iPS:336041 2G10_LC1 NA GAAATAGTGATGACGCAGTCTCCAGCCACCCTG CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCAGCATCTGGATTCACCTTCAGTAACTATGGC GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC ATGCACTGGGTCCGCCAGGCTCCAGGCGAGGGG AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC CTGGAGTGGGTGGCAGCTATATGGTTTGATGGA ACTGGTATCCCAGCCAGGGTCAGTGGCAGTGGG AGTGATAAATACTATGCAGACTCCGTGAAGGGC TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC CTGCAGTCTGAAGATTTTGCAGTTTATTACTGTC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC AGCAGTATAATAACTGGCCTCTCACTTTCGGCG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GAGGGACCAAGGTGGAGATCAAACGAACGGTG CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG GCTGCACCATCTGTCTTCATCTTCCCGCCATCTG GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC ATGAGCAGTTGAAATCTGGAACTGCCTCTGTTG TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA TGTGCCTGCTGAATAACTTCTATCCCAGAGAGG CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG CCAAAGTACAGTGGAAGGTGGATAACGCCCTCC GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC AATCGGGTAACTCCCAGGAGAGTGTCACAGAGC GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC AGGACAGCAAGGACAGCACCTACAGCCTCAGC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC AGCACCCTGACGCTGAGCAAAGCAGACTACGAG CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC AAACACAAAGTCTACGCCTGCGAAGTCACCCAT GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTC CAGACCTACATCTGCAACGTGAATCACAAGCCC AACAGGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1894 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2051 AA EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM YQQKPGQAPRLLIYGAATRATGIPARVSGSGSGTE HWVRQAPGEGLEWVAAIWFDGSDKYYADSVKG FTLTISSLQSEDFAVYYCQQYNNWPLTFGGGTKVE RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ IKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYP AIFGVVPDYWGQGTLVTVSSASTKGPSVFPLAPSS REAKVQWKVDNALQSGNSQESVTEQDSKDSTYSL KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG SSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV RGEC NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG SEQ ID NO: 324 GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 481 iPS:336077 4H9.004 NA GACATTCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGGCATTAGAAATGAGTTAG GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AACGCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGGAA GTGGGGTCCCATCAAGGTTCAGCGGCAGTGGAT GTAATAAATACTATGCAGACTCCGTGAAGGGCC CTGGGACAGAGTTCACTCTCACAATCAGCAGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTTGTAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAGTTACCCATTCACTTTCGGCCCT AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGGACCAAAGTGGATGTCAAACGAACGGTGGCT GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1895 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2052 AA DIQMTQSPSSLSASVGDRVTITCRASQGIRNELGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM YQQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDGSNKYYADSVKG FTLTISSLQPEDFVTYYCLQHNSYPFTFGPGTKVDV RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR TIFGVLLGDYWGQGTLVTVSSASTKGPSVFPLAPS EAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN RGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 325 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 482 iPS:336088 6A5.004 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTGGGGGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTACCAACTATTTAA GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC AACTCCTGATCTACGATGCTTCCAATTTGGAGCC TGGAGTGGGTGGCAGCTATATGGTATGATGGAA AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC ATAATAAATACTATGCAGACTCCGTGAAGGGCC TGGGACAGATTTTACTTTCACCATCAGCAGCCTG GATTCACCATCTCCAGAGACAGTTCCAAGAACA CAGCCTGAAGATATTGCAACATATTACTGTCAA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG CAGTATGATGATCTATTCACTTTCGGCCCTGGGA AGGACACGGCTGTGTATTACTGTGCGAGAGATC CCAAAGTGGATATCAAACGAACGGTGGCTGCAC GGACGATTTTTGGAGTGGTCCTTGAGTACCTCG CATCTGTCTTCATCTTCCCGCCATCTGATGAGCA GCCAGGGAACCCTGGTCACCGTCTCCTCAGCCT GTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTG CCACCAAGGGCCCATCGGTCTTCCCCCTGGCAC CTGAATAACTTCTATCCCAGAGAGGCCAAAGTA CCTCCTCCAAGAGCACCTCTGGGGGCACAGCGG CAGTGGAAGGTGGATAACGCCCTCCAATCGGGT CCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG AACTCCCAGGAGAGTGTCACAGAGCAGGACAG AACCGGTGACGGTGTCGTGGAACTCAGGCGCCC CAAGGACAGCACCTACAGCCTCAGCAGCACCCT TGACCAGCGGCGTGCACACCTTCCCGGCTGTCC GACGCTGAGCAAAGCAGACTACGAGAAACACA TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGT AAGTCTACGCCTGCGAAGTCACCCATCAGGGCC GGTGACCGTGCCCTCCAGCAGCTTGGGCACCCA TGAGCTCGCCCGTCACAAAGAGCTTCAACAGGG GACCTACATCTGCAACGTGAATCACAAGCCCAG GAGAGTGT CAACACCAAGGTGGACAAGAAAGTTGAGCCCA SEQ ID NO: 1896 AATCTTGTGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAACTCCTGGGGGGACCGTCAG TCTTCCTCTTCCCCCCAAAACCCAAGGACACCCT CATGATCTCCCGGACCCCTGAGGTCACATGCGT GGTGGTGGACGTGAGCCACGAAGACCCTGAGGT CAAGTTCAACTGGTACGTGGACGGCGTGGAGGT GCATAATGCCAAGACAAAGCCGTGTGAGGAGC AGTACGGCAGCACGTACCGTTGTGTCAGCGTCC TCACCGTCCTGCACCAGGACTGGCTGAATGGCA AGGAGTACAAGTGCAAGGTCTCCAACAAAGCCC TCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTAC ACCCTGCCCCCATCCCGGGAGGAGATGACCAAG AACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC TTCTATCCCAGCGACATCGCCGTGGAGTGGGAG AGCAATGGGCAGCCGGAGAACAACTACAAGAC CACGCCTCCCGTGCTGGACTCCGACGGCTCCTTC TTCCTCTATAGCAAGCTCACCGTGGACAAGAGC AGGTGGCAGCAGGGGAACGTCTTCTCATGCTCC GTGATGCATGAGGCTCTGCACAACCACTACACG CAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2053 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD HWVRQPPGKGLEWVAAIWYDGNNKYYADSVKG FTFTISSLQPEDIATYYCQQYDDLFTFGPGTKVDIK RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE TIFGVVLEYLGQGTLVTVSSASTKGPSVFPLAPSSK AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSS STSGGTAALGCLVKDYFPEPVTVSWNSGALTSGV TLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR HTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVN GEC HKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGP SEQ ID NO: 326 SVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEV KFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSVL TVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAK GQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPS DIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKL TVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSL SPGK SEQ ID NO: 483 iPS:336099 17H11.004 NA GACATCCAGATGACCCAGTCTCCATCTTCCGTGT CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTG CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTGAAGCCTTCGGAGACCCTGTCCCTCACCTGC GTCGGGCGAGTCAGGGTCTTATCATCTGGTTAG ACTGTCTCTCAGGGCTCCATCAGTAGTTACTACT CCTGGTATCAGCAGAAACCGGGGAAAGCCCCTA GGAGCTGGATCCGGCAGCCCGCCGGGAAGGGA AACTCCTGATCTATGCTGCATCCAGTTTGCAAAG CTAGAGTGGATTGGCCGTATCTATACCAGTGGG TGGGGTCCCATCAAGGTTCAGCGGCAGTGGCTC AGCACCAACTACAACCCCTCCCTCAAGAGTCGA TGGGACAGATTTCACTCTCACCATCAGCAGCCT GTCACCATGTCAATAGACACGTCCAAGAACCAG ACAGCCTGAAGATTTTGCAACTTACTATTGTCAA TTCTCCCTGAAACTGAACTCTGTGACCGCCGCG CAGACTAACAGTTTCCCTCCGACGTTCGGCCAA GACACGGCCGTGTATTACTGTGCGAGAGATGTA GGGACCAAGGTGGAAATCAAACGAACGGTGGC GCAGTGGCTGGCTTTGACTACTGGGGCCAGGGA TGCACCATCTGTCTTCATCTTCCCGCCATCTGAT ACCCTGGTCACCGTCTCCTCAGCCTCCACCAAG GAGCAGTTGAAATCTGGAACTGCCTCTGTTGTG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCA TGCCTGCTGAATAACTTCTATCCCAGAGAGGCC AGAGCACCTCTGGGGGCACAGCGGCCCTGGGCT AAAGTACAGTGGAAGGTGGATAACGCCCTCCAA GCCTGGTCAAGGACTACTTCCCCGAACCGGTGA TCGGGTAACTCCCAGGAGAGTGTCACAGAGCAG CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCG GACAGCAAGGACAGCACCTACAGCCTCAGCAGC GCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC ACCCTGACGCTGAGCAAAGCAGACTACGAGAA AGGACTCTACTCCCTCAGCAGCGTGGTGACCGT ACACAAAGTCTACGCCTGCGAAGTCACCCATCA GCCCTCCAGCAGCTTGGGCACCCAGACCTACAT GGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAA CTGCAACGTGAATCACAAGCCCAGCAACACCAA CAGGGGAGAGTGT GGTGGACAAGAAAGTTGAGCCCAAATCTTGTGA SEQ ID NO: 1897 CAAAACTCACACATGCCCACCGTGCCCAGCACC TGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTC CCCCCAAAACCCAAGGACACCCTCATGATCTCC CGGACCCCTGAGGTCACATGCGTGGTGGTGGAC GTGAGCCACGAAGACCCTGAGGTCAAGTTCAAC TGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGTGTGAGGAGCAGTACGGCAG CACGTACCGTTGTGTCAGCGTCCTCACCGTCCTG CACCAGGACTGGCTGAATGGCAAGGAGTACAA GTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACCACAGGTGTACACCCTGCCCCC ATCCCGGGAGGAGATGACCAAGAACCAGGTCA GCCTGACCTGCCTGGTCAAAGGCTTCTATCCCA GCGACATCGCCGTGGAGTGGGAGAGCAATGGG CAGCCGGAGAACAACTACAAGACCACGCCTCCC GTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAG CAGGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCTCTGCACAACCACTACACGCAGAAGAGC CTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2054 AA DIQMTQSPSSVSASVGDRVTITCRASQGLIIWLAW QVQLQESGPGLVKPSETLSLTCTVSQGSISSYYWS YQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTD WIRQPAGKGLEWIGRIYTSGSTNYNPSLKSRVTMS FTLTISSLQPEDFATYYCQQTNSFPPTFGQGTKVEI IDTSKNQFSLKLNSVTAADTAVYYCARDVAVAGF KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR DYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGT EAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS AALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAV STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN LQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT RGEC KVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFP SEQ ID NO: 327 PKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWY VDGVEVHNAKTKPCEEQYGSTYRCVSVLTVLHQ DWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREP QVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVE WESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKS RWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 484 iPS:359621 17H11.004.001 NA GACATCCAGATGACCCAGTCTCCATCTTCCGTGT CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTG CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTGAAGCCTTCGGAGACCCTGTCCCTCACCTGC GTCGGGCGAGTCAGGGTCTTATCATCTGGTTAG ACTGTCTCTGGGGGCTCCATCAGTAGTTACTACT CCTGGTATCAGCAGAAACCGGGGAAAGCCCCTA GGAGCTGGATCCGGCAGCCCGCCGGGAAGGGA AACTCCTGATCTATGCTGCATCCAGTTTGCAAAG CTAGAGTGGATTGGCCGTATCTATACCAGTGGG TGGGGTCCCATCAAGGTTCAGCGGCAGTGGCTC AGCACCAACTACAACCCCTCCCTCAAGAGTCGA TGGGACAGATTTCACTCTCACCATCAGCAGCCT GTCACCATGTCAATAGACACGTCCAAGAACCAG ACAGCCTGAAGATTTTGCAACTTACTATTGTCAA TTCTCCCTGAAACTGAACTCTGTGACCGCCGCG CAGACTAACAGTTTCCCTCCGACGTTCGGCCAA GACACGGCCGTGTATTACTGTGCGAGAGATGTA GGGACCAAGGTGGAAATCAAACGAACGGTGGC GCAGTGGCTGGCTTTGACTACTGGGGCCAGGGA TGCACCATCTGTCTTCATCTTCCCGCCATCTGAT ACCCTGGTCACCGTCTCCTCAGCCTCCACCAAG GAGCAGTTGAAATCTGGAACTGCCTCTGTTGTG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCA TGCCTGCTGAATAACTTCTATCCCAGAGAGGCC AGAGCACCTCTGGGGGCACAGCGGCCCTGGGCT AAAGTACAGTGGAAGGTGGATAACGCCCTCCAA GCCTGGTCAAGGACTACTTCCCCGAACCGGTGA TCGGGTAACTCCCAGGAGAGTGTCACAGAGCAG CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCG GACAGCAAGGACAGCACCTACAGCCTCAGCAGC GCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC ACCCTGACGCTGAGCAAAGCAGACTACGAGAA AGGACTCTACTCCCTCAGCAGCGTGGTGACCGT ACACAAAGTCTACGCCTGCGAAGTCACCCATCA GCCCTCCAGCAGCTTGGGCACCCAGACCTACAT GGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAA CTGCAACGTGAATCACAAGCCCAGCAACACCAA CAGGGGAGAGTGT GGTGGACAAGAAAGTTGAGCCCAAATCTTGTGA SEQ ID NO: 1898 CAAAACTCACACATGCCCACCGTGCCCAGCACC TGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTC CCCCCAAAACCCAAGGACACCCTCATGATCTCC CGGACCCCTGAGGTCACATGCGTGGTGGTGGAC GTGAGCCACGAAGACCCTGAGGTCAAGTTCAAC TGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGTGTGAGGAGCAGTACGGCAG CACGTACCGTTGTGTCAGCGTCCTCACCGTCCTG CACCAGGACTGGCTGAATGGCAAGGAGTACAA GTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACCACAGGTGTACACCCTGCCCCC ATCCCGGGAGGAGATGACCAAGAACCAGGTCA GCCTGACCTGCCTGGTCAAAGGCTTCTATCCCA GCGACATCGCCGTGGAGTGGGAGAGCAATGGG CAGCCGGAGAACAACTACAAGACCACGCCTCCC GTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAG CAGGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCTCTGCACAACCACTACACGCAGAAGAGC CTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2055 AA DIQMTQSPSSVSASVGDRVTITCRASQGLIIWLAW QVQLQESGPGLVKPSETLSLTCTVSGGSISSYYWS YQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTD WIRQPAGKGLEWIGRIYTSGSTNYNPSLKSRVTMS FTLTISSLQPEDFATYYCQQTNSFPPTFGQGTKVEI IDTSKNQFSLKLNSVTAADTAVYYCARDVAVAGF KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR DYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGT EAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS AALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAV STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN LQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT RGEC KVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFP SEQ ID NO: 328 PKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWY VDGVEVHNAKTKPCEEQYGSTYRCVSVLTVLHQ DWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREP QVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVE WESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKS RWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 485 iPS:359781 4H9.004.001 NA GACATTCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGGCATTAGAAATGAGTTAG GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AACTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCATCAAGGTTCAGCGGCAGTGGAT GTAATAAATACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAGTTCACTCTCACAATCAGCAGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTTGTAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAGTTACCCATTCACTTTCGGCCA AGGACACGGCTGTGTATTACTGTGCGCGAGATG AGGGACCAAAGTGGATGTCAAACGAACGGTGG GGACGATTTTTGGAGTGCTCTTGGGGGACTACT CTGCACCATCTGTCTTCATCTTCCCGCCATCTGA GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG TGAGCAGTTGAAATCTGGAACTGCCTCTGTTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GTGCCTGCTGAATAACTTCTATCCCAGAGAGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC CAAAGTACAGTGGAAGGTGGATAACGCCCTCCA GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCA CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC GGACAGCAAGGACAGCACCTACAGCCTCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT GCACCCTGACGCTGAGCAAAGCAGACTACGAGA CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC AACACAAAGTCTACGCCTGCGAAGTCACCCATC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC AGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCA CAGACCTACATCTGCAACGTGAATCACAAGCCC ACAGGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1899 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2056 AA DIQMTQSPSSLSASVGDRVTITCRASQGIRNELGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG FTLTISSLQPEDFVTYYCLQHNSYPFTFGQGTKVD RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG VKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFY TIFGVLLGDYWGQGTLVTVSSASTKGPSVFPLAPS PREAKVQWKVDNALQSGNSQESVTEQDSKDSTYS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS LSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSF GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN NRGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 329 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 486 iPS:360929 4H9.004.002 NA GACATTCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGGCATTAGAAATGAGTTAG GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AACTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCATCAAGGTTCAGCGGCAGTGGAT GTAATAAATACTATGCAGACTCCGTGAAGGGCC CTGGGACAGAGTTCACTCTCACAATCAGCAGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTTGTAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAGTTACCCATTCACTTTCGGCCA AGGACACGGCTGTGTATTACTGTGCGCGAGATG AGGGACCAAAGTGGATGTCAAACGAACGGTGG GGACGATTTTTGGAGTGCTCTTGGGGGACTACT CTGCACCATCTGTCTTCATCTTCCCGCCATCTGA GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG TGAGCAGTTGAAATCTGGAACTGCCTCTGTTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GTGCCTGCTGAATAACTTCTATCCCAGAGAGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC CAAAGTACAGTGGAAGGTGGATAACGCCCTCCA GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCA CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC GGACAGCAAGGACAGCACCTACAGCCTCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT GCACCCTGACGCTGAGCAAAGCAGACTACGAGA CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC AACACAAAGTCTACGCCTGCGAAGTCACCCATC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC AGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCA CAGACCTACATCTGCAACGTGAATCACAAGCCC ACAGGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1900 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2057 AA DIQMTQSPSSLSASVGDRVTITCRASQGIRNELGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDASNKYYADSVKG FTLTISSLQPEDFVTYYCLQHNSYPFTFGQGTKVD RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG VKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFY TIFGVLLGDYWGQGTLVTVSSASTKGPSVFPLAPS PREAKVQWKVDNALQSGNSQESVTEQDSKDSTYS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS LSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSF GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN NRGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 330 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 487 iPS:360936 4H9.004.003 NA GACATTCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGGCATTAGAAATGAGTTAG GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AACTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGGAA GTGGGGTCCCATCAAGGTTCAGCGGCAGTGGAT GTAATAAATACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAGTTCACTCTCACAATCAGCAGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTTGTAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAGTTACCCATTCACTTTCGGCCA AGGACACGGCTGTGTATTACTGTGCGCGAGATG AGGGACCAAAGTGGATGTCAAACGAACGGTGG GGACGATTTTTGGAGTGCTCTTGGGGGACTACT CTGCACCATCTGTCTTCATCTTCCCGCCATCTGA GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG TGAGCAGTTGAAATCTGGAACTGCCTCTGTTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GTGCCTGCTGAATAACTTCTATCCCAGAGAGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC CAAAGTACAGTGGAAGGTGGATAACGCCCTCCA GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCA CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC GGACAGCAAGGACAGCACCTACAGCCTCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT GCACCCTGACGCTGAGCAAAGCAGACTACGAGA CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC AACACAAAGTCTACGCCTGCGAAGTCACCCATC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC AGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCA CAGACCTACATCTGCAACGTGAATCACAAGCCC ACAGGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1901 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2058 AA DIQMTQSPSSLSASVGDRVTITCRASQGIRNELGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDGSNKYYADAVKG FTLTISSLQPEDFVTYYCLQHNSYPFTFGQGTKVD RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG VKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFY TIFGVLLGDYWGQGTLVTVSSASTKGPSVFPLAPS PREAKVQWKVDNALQSGNSQESVTEQDSKDSTYS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS LSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSF GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN NRGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 331 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 488 iPS:360943 4H9.004.004 NA GACATTCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGGCATTAGAAATGAGTTAG GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AACTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCATCAAGGTTCAGCGGCAGTGGAT GTAATAAATACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAGTTCACTCTCACAATCAGCAGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTTGTAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAGTTACCCATTCACTTTCGGCCCT AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGGACCAAAGTGGATGTCAAACGAACGGTGGCT GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1902 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2059 AA DIQMTQSPSSLSASVGDRVTITCRASQGIRNELGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG FTLTISSLQPEDFVTYYCLQHNSYPFTFGPGTKV RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG DVKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNN TIFGVLLGDYWGQGTLVTVSSASTKGPSVFPLAPS FYPREAKVQWKVDNALQSGNSQESVTEQDSKDST SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS YSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVT GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN KSFNRGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 332 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 489 iPS:360949 4H9.004.005 NA GACATTCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGGCATTAGAAATGAGTTAG GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AACGCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCATCAAGGTTCAGCGGCAGTGGAT GTAATAAATACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAGTTCACTCTCACAATCAGCAGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTTGTAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAGTTACCCATTCACTTTCGGCCA AGGACACGGCTGTGTATTACTGTGCGCGAGATG AGGGACCAAAGTGGATGTCAAACGAACGGTGG GGACGATTTTTGGAGTGCTCTTGGGGGACTACT CTGCACCATCTGTCTTCATCTTCCCGCCATCTGA GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG TGAGCAGTTGAAATCTGGAACTGCCTCTGTTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GTGCCTGCTGAATAACTTCTATCCCAGAGAGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC CAAAGTACAGTGGAAGGTGGATAACGCCCTCCA GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCA CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC GGACAGCAAGGACAGCACCTACAGCCTCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT GCACCCTGACGCTGAGCAAAGCAGACTACGAGA CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC AACACAAAGTCTACGCCTGCGAAGTCACCCATC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC AGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCA CAGACCTACATCTGCAACGTGAATCACAAGCCC ACAGGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1903 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2060 AA DIQMTQSPSSLSASVGDRVTITCRASQGIRNELGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM YQQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG FTLTISSLQPEDFVTYYCLQHNSYPFTFGQGTKVD RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG VKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFY TIFGVLLGDYWGQGTLVTVSSASTKGPSVFPLAPS PREAKVQWKVDNALQSGNSQESVTEQDSKDSTYS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS LSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSF GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN NRGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 333 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 490 iPS:359761 4H9.004.006 NA GACATTCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGGCATTAGAAATGAGTTAG GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AACTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCATCAAGGTTCAGCGGCAGTGGAT GTAATAAATACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAGTTCACTCTCACAATCAGCAGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTTGTAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAGTTACCCATTCACTTTCGGCCA AGGACACGGCTGTGTATTACTGTGCGCGAGATA AGGGACCAAAGTGGATGTCAAACGAACGGTGG GGACGATTTTTGGAGTGCTCTTGGGGGACTACT CTGCACCATCTGTCTTCATCTTCCCGCCATCTGA GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG TGAGCAGTTGAAATCTGGAACTGCCTCTGTTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GTGCCTGCTGAATAACTTCTATCCCAGAGAGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC CAAAGTACAGTGGAAGGTGGATAACGCCCTCCA GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCA CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC GGACAGCAAGGACAGCACCTACAGCCTCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT GCACCCTGACGCTGAGCAAAGCAGACTACGAGA CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC AACACAAAGTCTACGCCTGCGAAGTCACCCATC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC AGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCA CAGACCTACATCTGCAACGTGAATCACAAGCCC ACAGGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1904 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2061 AA DIQMTQSPSSLSASVGDRVTITCRASQGIRNELGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG FTLTISSLQPEDFVTYYCLQHNSYPFTFGQGTKVD RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR VKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFY TIFGVLLGDYWGQGTLVTVSSASTKGPSVFPLAPS PREAKVQWKVDNALQSGNSQESVTEQDSKDSTYS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS LSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSF GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN NRGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 334 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 491 iPS:360955 4B1.010 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAATA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGTCG ACAGCATAATAATTACCCCTTCACTTTCGGCCAA CGGACACGGCTGTGTATTATTGTGCGCGAGATG GGGACCAAAGTGGATATCAAACGAACGGTGGCT GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1905 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2062 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT HWVRQAPGKGLEWVAVIWYDASNENYADAVKG LTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDIK RFTISRDNSKNTLYLQMNSLRVADTAVYYCARDG RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS TLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN GEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 335 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 492 iPS:360962 4B1.011 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAATA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGTCG ACAGCATAATAATTACCCCTTCACTTTCGGCCAA CGGACACGGCTGTGTATTATTGTGCGCGAGATG GGGACCAAAGTGGATATCAAACGAACGGTGGCT GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1906 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2063 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM QQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTEFT HWVRQAPGKGLEWVAVIWYDASNENYADAVKG LTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDIK RFTISRDNSKNTLYLQMNSLRVADTAVYYCARDG RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS TLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN GEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 336 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 493 iPS:360968 4B1.012 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAATA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGTCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT CGGACACGGCTGTGTATTATTGTGCGCGAGATG GGGACCAAAGTGGATATCAAACGAACGGTGGCT GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1907 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2064 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYL QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM GWYQQKPGKAPKLLIYGASSLQSGVPSRFSGSG HWVRQAPGKGLEWVAVIWYDASNENYADAVKG SGTEFTLTISSLQPEDFATYYCLQHNNYPFTFG RFTISRDNSKNTLYLQMNSLRVADTAVYYCARDG PGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASV TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS VCLLNNFYPREAKVQWKVDNALQSGNSQESVTE SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS QDSKDSTYSLSSTLTLSKADYEKHKVYACEVTH GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN QGLSSPVTKSFNRGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 337 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 494 iPS:360974 4B1.013 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACTCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAATA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCACATGAACAGCCTGAGAGTCG ACAGCATAATAATTACCCCTTCACTTTCGGCCAA CGGACACGGCTGTGTATTATTGTGCGCGAGATG GGGACCAAAGTGGATATCAAACGAACGGTGGCT GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1908 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2065 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT HWVRQAPGKGLEWVAVIWYDASNENYADSVKG LTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDIK RFTISRDNSKNTLYLHMNSLRVADTAVYYCARDG RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL TLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED GEC PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SEQ ID NO: 338 SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 495 iPS:360978 4B1.014 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGGAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAATA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCACATGAACAGCCTGAGAGTCG ACAGCATAATAATTACCCCTTCACTTTCGGCCAA CGGACACGGCTGTGTATTATTGTGCGCGAGATG GGGACCAAAGTGGATATCAAACGAACGGTGGCT GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1909 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2066 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT HWVRQAPGKGLEWVAVIWYDGSNENYADAVKG LTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDIK RFTISRDNSKNTLYLHMNSLRVADTAVYYCARDG RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS TLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN GEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 339 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 496 iPS:359785 4B1.015 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAATA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGTCG ACAGCATAATAATTACCCCTTCACTTTCGGCCAA AGGACACGGCTGTGTATTATTGTGCGCGAGATA GGGACCAAAGTGGATATCAAACGAACGGTGGCT GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1910 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2067 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT HWVRQAPGKGLEWVAVIWYDASNENYADAVKG LTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDIK RFTISRDNSKNTLYLQMNSLRVEDTAVYYCARDR RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS TLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN GEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 340 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 497 iPS:360982 4B1.016 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAATA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGTCG ACAGCATAATAATTACCCCTTCACTTTCGGCCAA AGGACACGGCTGTGTATTATTGTGCGCGAGATG GGGACCAAAGTGGATATCAAACGAACGGTGGCT GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1911 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2068 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT HWVRQAPGKGLEWVAVIWYDASNENYADAVKG LTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDIK RFTISRDNSKNTLYLQMNSLRVEDTAVYYCARDG RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS TLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN GEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 341 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 498 iPS:335922 18F2 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCACCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGGAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACTCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCACATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGGACCAAAGTGGATATCAAACGAACGGTGGCT GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1912 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2069 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM YHQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDGSNENYADSVKG FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKV RFTISRDNSKNTLYLHMNSLRAADTAVYYCARDG DIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNN TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS FYPREAKVQWKVDNALQSGNSQESVTEQDSKDST SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS YSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVT GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN KSFNRGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 342 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 499 iPS:360986 18F2.002 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGGACCAAAGTGGATATCAAACGAACGGTGGCT GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1913 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2070 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDASNENYADAVKG FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI RFTISRDNSKNTLYLQMNSLRAADTAVYYCARDG KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS EAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN RGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 343 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 500 iPS:360995 18F2.003 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCACATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGGACCAAAGTGGATATCAAACGAACGGTGGCT GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1914 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2071 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDASNENYADAVKG FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI RFTISRDNSKNTLYLHMNSLRAADTAVYYCARDG KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS EAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN RGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 344 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 501 iPS:360999 18F2.004 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCACCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGGACCAAAGTGGATATCAAACGAACGGTGGCT GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1915 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2072 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM YHQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDASNENYADAVKG FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI RFTISRDNSKNTLYLQMNSLRAADTAVYYCARDG KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS EAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN RGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 345 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 502 iPS:361005 18F2.005 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGGACCAAAGTGGATATCAAACGAACGGTGGCT GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1916 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2073 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM YQQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDASNENYADAVKG FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVD IRFTISRDNSKNTLYLQMNSLRAADTAVYYCARDG KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS EAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN RGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 346 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 503 iPS:361009 18F2.006 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCACATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGGACCAAAGTGGATATCAAACGAACGGTGGCT GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1917 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2074 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM YQQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDASNENYADAVKG FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKV RFTISRDNSKNTLYLHMNSLRAADTAVYYCARDG DIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNN TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS FYPREAKVQWKVDNALQSGNSQESVTEQDSKDST SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS YSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVT GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN KSFNRGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 347 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 504 iPS:361013 18F2.007 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCACCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCACATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGGACCAAAGTGGATATCAAACGAACGGTGGCT GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1918 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2075 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM YHQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDASNENYADAVKG FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI RFTISRDNSKNTLYLHMNSLRAADTAVYYCARDG KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS EAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN RGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 348 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 505 iPS:361017 18F2.008 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCACCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGGACCAAAGTGGATATCAAACGAACGGTGGCT GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1919 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2076 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM YHQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDASNENYADAVKG FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI RFTISRDNSKNTLYLQMNSLRAADTAVYYCARDG KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS EAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN RGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 349 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 506 iPS:361021 18F2.009 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGGAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGGACCAAAGTGGATATCAAACGAACGGTGGCT GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1920 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2077 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDGSNENYADAVKG FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI RFTISRDNSKNTLYLQMNSLRAADTAVYYCARDG KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS EAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN RGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 350 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 507 iPS:361028 18F2.010 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACTCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT CGGACACGGCTGTGTATTACTGTGCGAGAGATG GGGACCAAAGTGGATATCAAACGAACGGTGGCT GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1921 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2078 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDGSNENYADAVKG FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI RFTISRDNSKNTLYLQMNSLRAADTAVYYCARDG KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS EAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN RGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 351 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 508 iPS:360535 18F2.011 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCAA AGGACACGGCTGTGTATTACTGTGCGAGAGATA GGGACCAAAGTGGATATCAAACGAACGGTGGCT GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1922 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2079 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDASNENYADAVKG FTLTISSLQPEDFATYYCLQHNNYPFTFGQGTKV RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR DIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNN TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS FYPREAKVQWKVDNALQSGNSQESVTEQDSKDST SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS YSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVT GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN KSFNRGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 352 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 509 iPS:361035 18F2.012 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT AGGACACGGCTGTGTATTACTGTGCGAGAGATG GGGACCAAAGTGGATATCAAACGAACGGTGGCT GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1923 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2080 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM YQQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDASNENYADAVKG FTLTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDI RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS EAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN RGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 353 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 510 iPS:359940 2F11.002 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTACGATGCATCCAATTTGGAAA CTGGAGTGGGTGGCAGTTATATGGTATGATGCA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT AGTAATAAATACTATGCAGACGCCGTGAAGGGC CTGGGACAGATTTTAGTCTCACCATCAGCAGCC CGATTCACCATCTCCAGGGACAATTCCAAGAAC TGCAGCCTGAAGATTTTGCAACATATTACTGTCA ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC ACAGTATGATATTCTCCTCACTTTCGGCGGAGG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GACCAAGGTGGAGATCAAGCGAACGGTGGCTG AGGACGATTTTTGGAGTGGTTCTTGACTACTGG CACCATCTGTCTTCATCTTCCCGCCATCTGATGA GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC GCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGC TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA CTGCTGAATAACTTCTATCCCAGAGAGGCCAAA CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG GTACAGTGGAAGGTGGATAACGCCCTCCAATCG GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC GGTAACTCCCAGGAGAGTGTCACAGAGCAGGAC GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC AGCAAGGACAGCACCTACAGCCTCAGCAGCACC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC CTGACGCTGAGCAAAGCAGACTACGAGAAACA CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC CAAAGTCTACGCCTGCGAAGTCACCCATCAGGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CCTGAGCTCGCCCGTCACAAAGAGCTTCAACAG CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1924 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2081 AA DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG FSLTISSLQPEDFATYYCQQYDILLTFGGGTKVEIK RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE TIFGVVLDYWGQGTLVTVSSASTKGPSVFPLAPSS AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSS KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG TLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV GEC NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG SEQ ID NO: 354 GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 511 iPS:361039 2F11.003 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTACGATGCATCCAATTTGGAAA CTGGAGTGGGTGGCAGTTATATGGTATGATGCA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT AGTAATAAATACTATGCAGACGCCGTGAAGGGC CTGGGACAGATTTTAGTCTCACCATCAGCAGCC CGATTCACCATCTCCAGCGACAATTCCAAGAAC TGCAGCCTGAAGATTTTGCAACATATTACTGTCA ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC ACAGTATGATATTCTCCTCACTTTCGGCGGAGG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GACCAAGGTGGAGATCAAGCGAACGGTGGCTG AGGACGATTTTTGGAGTGGTTCTTGACTACTGG CACCATCTGTCTTCATCTTCCCGCCATCTGATGA GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC GCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGC TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA CTGCTGAATAACTTCTATCCCAGAGAGGCCAAA CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG GTACAGTGGAAGGTGGATAACGCCCTCCAATCG GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC GGTAACTCCCAGGAGAGTGTCACAGAGCAGGAC GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC AGCAAGGACAGCACCTACAGCCTCAGCAGCACC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC CTGACGCTGAGCAAAGCAGACTACGAGAAACA CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC CAAAGTCTACGCCTGCGAAGTCACCCATCAGGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CCTGAGCTCGCCCGTCACAAAGAGCTTCAACAG CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1925 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2082 AA DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG FSLTISSLQPEDFATYYCQQYDILLTFGGGTKVEIK RFTISSDNSKNTLYLQMNSLRAEDTAVYYCARDR RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE TIFGVVLDYWGQGTLVTVSSASTKGPSVFPLAPSS AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSS KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG TLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV GEC NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG SEQ ID NO: 355 GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 512 iPS:361043 2F11.004 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTACGATGCATCCAATTTGGAAA CTGGAGTGGGTGGCAGTTATATGGTATGATGCA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT AGTAATAAATACTATGCAGACGCCGTGAAGGGC CTGGGACAGATTTTAGTCTCACCATCAGCAGCC CGATTCACCATCTCCAGGGACAATTCCAAGAAC TGCAGCCTGAAGATATTGCAACATATTACTGTC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC AACAGTATGATATTCTCCTCACTTTCGGCGGAG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GGACCAAGGTGGAGATCAAGCGAACGGTGGCT AGGACGATTTTTGGAGTGGTTCTTGACTACTGG GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1926 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2083 AA DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG FSLTISSLQPEDIATYYCQQYDILLTFGGGTKVEI RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYP TIFGVVLDYWGQGTLVTVSSASTKGPSVFPLAPSS REAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV GEC NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG SEQ ID NO: 356 GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 513 iPS:361049 2F11.005 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTACGATGCATCCAATTTGGAAA CTGGAGTGGGTGGCAGTTATATGGTATGATGCA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT AGTAATAAATACTATGCAGACGCCGTGAAGGGC CTGGGACAGATTTTAGTTTCACCATCAGCAGCCT CGATTCACCATCTCCAGGGACAATTCCAAGAAC GCAGCCTGAAGATTTTGCAACATATTACTGTCA ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC ACAGTATGATATTCTCCTCACTTTCGGCGGAGG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GACCAAGGTGGAGATCAAGCGAACGGTGGCTG AGGACGATTTTTGGAGTGGTTCTTGACTACTGG CACCATCTGTCTTCATCTTCCCGCCATCTGATGA GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC GCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGC TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA CTGCTGAATAACTTCTATCCCAGAGAGGCCAAA CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG GTACAGTGGAAGGTGGATAACGCCCTCCAATCG GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC GGTAACTCCCAGGAGAGTGTCACAGAGCAGGAC GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC AGCAAGGACAGCACCTACAGCCTCAGCAGCACC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC CTGACGCTGAGCAAAGCAGACTACGAGAAACA CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC CAAAGTCTACGCCTGCGAAGTCACCCATCAGGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CCTGAGCTCGCCCGTCACAAAGAGCTTCAACAG CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1927 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2084 AA DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG FSFTISSLQPEDFATYYCQQYDILLTFGGGTKVEI RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYP TIFGVVLDYWGQGTLVTVSSASTKGPSVFPLAPSS REAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV GEC NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG SEQ ID NO: 357 GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 514 iPS:361055 2F11.006 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTACGATGCATCCAATTTGGAAA CTGGAGTGGGTGGCAGTTATATGGTATGATGCA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT AGTAATAAATACTATGCAGACGCCGTGAAGGGC CTGGGACAGATTTTAGTCTCACCATCAGCAGCC CGATTCACCATCTCCAGCGACAATTCCAAGAAC TGCAGCCTGAAGATATTGCAACATATTACTGTC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC AACAGTATGATATTCTCCTCACTTTCGGCGGAG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GGACCAAGGTGGAGATCAAGCGAACGGTGGCT AGGACGATTTTTGGAGTGGTTCTTGACTACTGG GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1928 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2085 AA DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG FSLTISSLQPEDIATYYCQQYDILLTFGGGTKVEI RFTISSDNSKNTLYLQMNSLRAEDTAVYYCARDR KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYP TIFGVVLDYWGQGTLVTVSSASTKGPSVFPLAPSS REAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV GEC NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG SEQ ID NO: 358 GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 515 iPS:361059 2F11.007 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTACGATGCATCCAATTTGGAAA CTGGAGTGGGTGGCAGTTATATGGTATGATGCA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT AGTAATAAATACTATGCAGACGCCGTGAAGGGC CTGGGACAGATTTTAGTTTCACCATCAGCAGCCT CGATTCACCATCTCCAGCGACAATTCCAAGAAC GCAGCCTGAAGATTTTGCAACATATTACTGTCA ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC ACAGTATGATATTCTCCTCACTTTCGGCGGAGG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GACCAAGGTGGAGATCAAGCGAACGGTGGCTG AGGACGATTTTTGGAGTGGTTCTTGACTACTGG CACCATCTGTCTTCATCTTCCCGCCATCTGATGA GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC GCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGC TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA CTGCTGAATAACTTCTATCCCAGAGAGGCCAAA CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG GTACAGTGGAAGGTGGATAACGCCCTCCAATCG GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC GGTAACTCCCAGGAGAGTGTCACAGAGCAGGAC GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC AGCAAGGACAGCACCTACAGCCTCAGCAGCACC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC CTGACGCTGAGCAAAGCAGACTACGAGAAACA CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC CAAAGTCTACGCCTGCGAAGTCACCCATCAGGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CCTGAGCTCGCCCGTCACAAAGAGCTTCAACAG CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1929 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2086 AA DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG FSFTISSLQPEDFATYYCQQYDILLTFGGGTKVEIK RFTISSDNSKNTLYLQMNSLRAEDTAVYYCARDR RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE TIFGVVLDYWGQGTLVTVSSASTKGPSVFPLAPSS AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSS KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG TLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV GEC NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG SEQ ID NO: 359 GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 516 iPS:361063 2F11.008 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTACGATGCATCCAATTTGGAAA CTGGAGTGGGTGGCAGTTATATGGTATGATGCA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT AGTAATAAATACTATGCAGACGCCGTGAAGGGC CTGGGACAGATTTTAGTTTCACCATCAGCAGCCT CGATTCACCATCTCCAGGGACAATTCCAAGAAC GCAGCCTGAAGATATTGCAACATATTACTGTCA ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC ACAGTATGATATTCTCCTCACTTTCGGCGGAGG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GACCAAGGTGGAGATCAAGCGAACGGTGGCTG AGGACGATTTTTGGAGTGGTTCTTGACTACTGG CACCATCTGTCTTCATCTTCCCGCCATCTGATGA GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC GCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGC TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA CTGCTGAATAACTTCTATCCCAGAGAGGCCAAA CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG GTACAGTGGAAGGTGGATAACGCCCTCCAATCG GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC GGTAACTCCCAGGAGAGTGTCACAGAGCAGGAC GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC AGCAAGGACAGCACCTACAGCCTCAGCAGCACC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC CTGACGCTGAGCAAAGCAGACTACGAGAAACA CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC CAAAGTCTACGCCTGCGAAGTCACCCATCAGGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CCTGAGCTCGCCCGTCACAAAGAGCTTCAACAG CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1930 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2087 AA DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG FSFTISSLQPEDIATYYCQQYDILLTFGGGTKVEI RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYP TIFGVVLDYWGQGTLVTVSSASTKGPSVFPLAPSS REAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV GEC NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG SEQ ID NO: 360 GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 517 iPS:359949 2F11.009 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTACGATGCATCCAATTTGGAAA CTGGAGTGGGTGGCAGTTATATGGTATGATGCA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT AGTAATAAATACTATGCAGACTCCGTGAAGGGC CTGGGACAGATTTTAGTCTCACCATCAGCAGCC CGATTCACCATCTCCAGGGACAATTCCAAGAAC TGCAGCCTGAAGATTTTGCAACATATTACTGTCA ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC ACAGTATGATATTCTCCTCACTTTCGGCGGAGG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GACCAAGGTGGAGATCAAGCGAACGGTGGCTG AGGACGATTTTTGGAGTGGTTCTTGACTACTGG CACCATCTGTCTTCATCTTCCCGCCATCTGATGA GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC GCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGC TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA CTGCTGAATAACTTCTATCCCAGAGAGGCCAAA CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG GTACAGTGGAAGGTGGATAACGCCCTCCAATCG GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC GGTAACTCCCAGGAGAGTGTCACAGAGCAGGAC GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC AGCAAGGACAGCACCTACAGCCTCAGCAGCACC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC CTGACGCTGAGCAAAGCAGACTACGAGAAACA CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC CAAAGTCTACGCCTGCGAAGTCACCCATCAGGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CCTGAGCTCGCCCGTCACAAAGAGCTTCAACAG CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1931 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2088 AA DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD HWVRQAPGKGLEWVAVIWYDASNKYYADSVKG FSLTISSLQPEDFATYYCQQYDILLTFGGGTKVEIK RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE TIFGVVLDYWGQGTLVTVSSASTKGPSVFPLAPSS AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSS KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG TLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV GEC NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG SEQ ID NO: 361 GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV ALTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 518 iPS:359956 2F11.010 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAACTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTAGCAACTATTTAA GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTACGATGCATCCAATTTGGAAA CTGGAGTGGGTGGCAGTTATATGGTATGATGGA CAGGGGTCCCATCAAGGTTCAGTGGAAGTGGAT AGTAATAAATACTATGCAGACGCCGTGAAGGGC CTGGGACAGATTTTAGTCTCACCATCAGCAGCC CGATTCACCATCTCCAGGGACAATTCCAAGAAC TGCAGCCTGAAGATTTTGCAACATATTACTGTCA ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC ACAGTATGATATTCTCCTCACTTTCGGCGGAGG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GACCAAGGTGGAGATCAAGCGAACGGTGGCTG AGGACGATTTTTGGAGTGGTTCTTGACTACTGG CACCATCTGTCTTCATCTTCCCGCCATCTGATGA GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC GCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGC TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA CTGCTGAATAACTTCTATCCCAGAGAGGCCAAA CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG GTACAGTGGAAGGTGGATAACGCCCTCCAATCG GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC GGTAACTCCCAGGAGAGTGTCACAGAGCAGGAC GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC AGCAAGGACAGCACCTACAGCCTCAGCAGCACC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC CTGACGCTGAGCAAAGCAGACTACGAGAAACA CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC CAAAGTCTACGCCTGCGAAGTCACCCATCAGGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CCTGAGCTCGCCCGTCACAAAGAGCTTCAACAG CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1932 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2089 AA DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGM YQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTD HWVRQAPGKGLEWVAVIWYDGSNKYYADAVKG FSLTISSLQPEDFATYYCQQYDILLTFGGGTKVEI RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYP TIFGVVLDYWGQGTLVTVSSASTKGPSVFPLAPSS REAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV GEC NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG SEQ ID NO: 362 GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 519 iPS:359865 6H1.002 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA AGCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATAAATACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGGACCAAAGTGGATATCAAACGAACGGTGGCT GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1933 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2090 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM QQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTEFT HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG LTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDIKR RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA TIFGVLLGDYWGQGTLVTVSSASTKGPSVFPLAPS KVQWKVDNALQSGNSQESVTEQDSKDSTYSLSST SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS LTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN EC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 363 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 520 iPS:359869 6H1.003 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATAAATACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT AGGACACGGCTGTGTATTACTGTGCGCGAGATA GGGACCAAAGTGGATATCAAACGAACGGTGGCT GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC AGCCTGCTGAATAACTTCTATCCCAGAGAGGCCA ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1934 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2091 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM QQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTEFT HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG LTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDIKR RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA TIFGVLLGDYWGQGTLVTVSSASTKGPSVFPLAPS KVQWKVDNALQSGNSQESVTEQDSKDSTYSLSST SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS LTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN EC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 364 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 521 iPS:359873 6H1.004 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATAAATACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCAA AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGGACCAAAGTGGATATCAAACGAACGGTGGCT GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1935 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2092 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG LTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDIK RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE TIFGVLLGDYWGQGTLVTVSSASTKGPSVFPLAPS AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS TLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN GEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 365 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 522 iPS:359877 6H1.005 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATAAATACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCAA AGGACACGGCTGTGTATTACTGTGCGCGAGATA GGGACCAAAGTGGATATCAAACGAACGGTGGCT GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1936 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC ACCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2093 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG LTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDIK RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE TIFGVLLGDYWGQGTLVTVSSASTKGPSVFPLAPS AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS TLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN GEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 366 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 523 iPS:361067 6H1.006 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGGAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATAAATACTATGCAGACTCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGGACCAAAGTGGATATCAAACGAACGGTGGCT GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1937 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC ATCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2094 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT HWVRQAPGKGLEWVAVIWYDGSNKYYADSVKG LTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDIKR RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA TIFGVLLGDYWGQGTLVTVSSASTKGPSVFPLAPS KVQWKVDNALQSGNSQESVTEQDSKDSTYSLSST SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS LTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN EC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 367 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 524 iPS:361071 6H1.007 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATAAATACTATGCAGACTCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGGACCAAAGTGGATATCAAACGAACGGTGGCT GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1938 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2095 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT HWVRQAPGKGLEWVAVIWYDASNKYYADSVKG LTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDIKR RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA TIFGVLLGDYWGQGTLVTVSSASTKGPSVFPLAPS KVQWKVDNALQSGNSQESVTEQDSKDSTYSLSST SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS LTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN AEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 368 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 525 iPS:361075 6H1.008 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCTCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGGAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATAAATACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCCT AGGACACGGCTGTGTATTACTGTGCGCGAGATG GGGACCAAAGTGGATATCAAACGAACGGTGGCT GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1939 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2096 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM QQKPGKAPKLLIYGASSLQSGVPSRFSGSGSGTEFT HWVRQAPGKGLEWVAVIWYDGSNKYYADAVKG LTISSLQPEDFATYYCLQHNNYPFTFGPGTKVDIKR RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA TIFGVLLGDYWGQGTLVTVSSASTKGPSVFPLAPS KVQWKVDNALQSGNSQESVTEQDSKDSTYSLSST SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS LTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN EC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 369 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 526 iPS:361079 6A5.004.001 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTGGGGGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTACCAACTATTTAA GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC AACTCCTGATCTACGATGCTTCCAATTTGGAGCC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC ATAATAAATACTATGCAGACGCCGTGAAGGGCC TGGGACAGATTTTACTCTCACCATCAGCAGCCT GATTCACCATCTCCAGAGACAGTTCCAAGAACA GCAGCCTGAAGATTTTGCAACATATTACTGTCA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGTATGATGATCTATTCACTTTCGGCCCTGGG AGGACACGGCTGTGTATTACTGTGCGAGAGATC ACCAAAGTGGATATCAAACGAACGGTGGCTGCA GGACGATTTTTGGAGTGGTCCTTGAGTACTGGG CCATCTGTCTTCATCTTCCCGCCATCTGATGAGC GCCAGGGAACCCTGGTCACCGTCTCCTCAGCCT AGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCT CCACCAAGGGCCCATCGGTCTTCCCCCTGGCAC GCTGAATAACTTCTATCCCAGAGAGGCCAAAGT CCTCCTCCAAGAGCACCTCTGGGGGCACAGCGG ACAGTGGAAGGTGGATAACGCCCTCCAATCGGG CCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG TAACTCCCAGGAGAGTGTCACAGAGCAGGACAG AACCGGTGACGGTGTCGTGGAACTCAGGCGCCC CAAGGACAGCACCTACAGCCTCAGCAGCACCCT TGACCAGCGGCGTGCACACCTTCCCGGCTGTCC GACGCTGAGCAAAGCAGACTACGAGAAACACA TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGT AAGTCTACGCCTGCGAAGTCACCCATCAGGGCC GGTGACCGTGCCCTCCAGCAGCTTGGGCACCCA TGAGCTCGCCCGTCACAAAGAGCTTCAACAGGG GACCTACATCTGCAACGTGAATCACAAGCCCAG GAGAGTGT CAACACCAAGGTGGACAAGAAAGTTGAGCCCA SEQ ID NO: 1940 AATCTTGTGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAACTCCTGGGGGGACCGTCAG TCTTCCTCTTCCCCCCAAAACCCAAGGACACCCT CATGATCTCCCGGACCCCTGAGGTCACATGCGT GGTGGTGGACGTGAGCCACGAAGACCCTGAGGT CAAGTTCAACTGGTACGTGGACGGCGTGGAGGT GCATAATGCCAAGACAAAGCCGTGTGAGGAGC AGTACGGCAGCACGTACCGTTGTGTCAGCGTCC TCACCGTCCTGCACCAGGACTGGCTGAATGGCA AGGAGTACAAGTGCAAGGTCTCCAACAAAGCCC TCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTAC ACCCTGCCCCCATCCCGGGAGGAGATGACCAAG AACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC TTCTATCCCAGCGACATCGCCGTGGAGTGGGAG AGCAATGGGCAGCCGGAGAACAACTACAAGAC CACGCCTCCCGTGCTGGACTCCGACGGCTCCTTC TTCCTCTATAGCAAGCTCACCGTGGACAAGAGC AGGTGGCAGCAGGGGAACGTCTTCTCATGCTCC GTGATGCATGAGGCTCTGCACAACCACTACACG CAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2097 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG FTLTISSLQPEDFATYYCQQYDDLFTFGPGTKVDIK RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE TIFGVVLEYWGQGTLVTVSSASTKGPSVFPLAPSS AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSS KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG TLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV GEC NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG SEQ ID NO: 370 GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 527 iPS:361085 6A5.004.002 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTGGGGGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTACCAACTATTTAA GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC AACTCCTGATCTACGATGCTTCCAATTTGGAGCC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC ATAATAAATACTATGCAGACGCCGTGAAGGGCC TGGGACAGATTTTACTCTCACCATCAGCAGCCT GATTCACCATCTCCAGAGACAGTTCCAAGAACA AGCAGCCTGAAGATATTGCAACATATTACTGTCA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGTATGATGATCTATTCACTTTCGGCCCTGGG AGGACACGGCTGTGTATTACTGTGCGAGAGATC ACCAAAGTGGATATCAAACGAACGGTGGCTGCA GGACGATTTTTGGAGTGGTCCTTGAGTACTGGG CCATCTGTCTTCATCTTCCCGCCATCTGATGAGC GCCAGGGAACCCTGGTCACCGTCTCCTCAGCCT AGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCT CCACCAAGGGCCCATCGGTCTTCCCCCTGGCAC GCTGAATAACTTCTATCCCAGAGAGGCCAAAGT CCTCCTCCAAGAGCACCTCTGGGGGCACAGCGG ACAGTGGAAGGTGGATAACGCCCTCCAATCGGG CCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG TAACTCCCAGGAGAGTGTCACAGAGCAGGACAG AACCGGTGACGGTGTCGTGGAACTCAGGCGCCC CAAGGACAGCACCTACAGCCTCAGCAGCACCCT TGACCAGCGGCGTGCACACCTTCCCGGCTGTCC GACGCTGAGCAAAGCAGACTACGAGAAACACA TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGT AAGTCTACGCCTGCGAAGTCACCCATCAGGGCC GGTGACCGTGCCCTCCAGCAGCTTGGGCACCCA TGAGCTCGCCCGTCACAAAGAGCTTCAACAGGG GACCTACATCTGCAACGTGAATCACAAGCCCAG GAGAGTGT CAACACCAAGGTGGACAAGAAAGTTGAGCCCA SEQ ID NO: 1941 AATCTTGTGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAACTCCTGGGGGGACCGTCAG TCTTCCTCTTCCCCCCAAAACCCAAGGACACCCT CATGATCTCCCGGACCCCTGAGGTCACATGCGT GGTGGTGGACGTGAGCCACGAAGACCCTGAGGT CAAGTTCAACTGGTACGTGGACGGCGTGGAGGT GCATAATGCCAAGACAAAGCCGTGTGAGGAGC AGTACGGCAGCACGTACCGTTGTGTCAGCGTCC TCACCGTCCTGCACCAGGACTGGCTGAATGGCA AGGAGTACAAGTGCAAGGTCTCCAACAAAGCCC TCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTAC ACCCTGCCCCCATCCCGGGAGGAGATGACCAAG AACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC TTCTATCCCAGCGACATCGCCGTGGAGTGGGAG AGCAATGGGCAGCCGGAGAACAACTACAAGAC CACGCCTCCCGTGCTGGACTCCGACGGCTCCTTC TTCCTCTATAGCAAGCTCACCGTGGACAAGAGC AGGTGGCAGCAGGGGAACGTCTTCTCATGCTCC GTGATGCATGAGGCTCTGCACAACCACTACACG CAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2098 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG FTLTISSLQPEDIATYYCQQYDDLFTFGPGTKVDIK RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE TIFGVVLEYWGQGTLVTVSSASTKGPSVFPLAPSS AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSS KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG TLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV GEC NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG SEQ ID NO: 371 GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 528 iPS:361091 6A5.004.003 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTGGGGGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTACCAACTATTTAA GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC AACTCCTGATCTACGATGCTTCCAATTTGGAGCC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC ATAATAAATACTATGCAGACGCCGTGAAGGGCC TGGGACAGATTTTACTCTCACCATCAGCAGCCT GATTCACCATCTCCAGAGACAGTTCCAAGAACA GCAGCCTGAAGATTTTGCAACATATTACTGTCA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGTATGATGATCTATTCACTTTCGGCCCTGGG AGGACACGGCTGTGTATTACTGTGCGAGAGATC ACCAAAGTGGATATCAAACGAACGGTGGCTGCA GGACGATTTTTGGAGTGGTCCTTGAGTACCTCG CCATCTGTCTTCATCTTCCCGCCATCTGATGAGC GCCAGGGAACCCTGGTCACCGTCTCCTCAGCCT AGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCT CCACCAAGGGCCCATCGGTCTTCCCCCTGGCAC GCTGAATAACTTCTATCCCAGAGAGGCCAAAGT CCTCCTCCAAGAGCACCTCTGGGGGCACAGCGG ACAGTGGAAGGTGGATAACGCCCTCCAATCGGG CCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG TAACTCCCAGGAGAGTGTCACAGAGCAGGACAG AACCGGTGACGGTGTCGTGGAACTCAGGCGCCC ACAAGGACAGCACCTACAGCCTCAGCAGCACCCT TGACCAGCGGCGTGCACACCTTCCCGGCTGTCC GACGCTGAGCAAAGCAGACTACGAGAAACACA TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGT AAGTCTACGCCTGCGAAGTCACCCATCAGGGCC GGTGACCGTGCCCTCCAGCAGCTTGGGCACCCA TGAGCTCGCCCGTCACAAAGAGCTTCAACAGGG GACCTACATCTGCAACGTGAATCACAAGCCCAG GAGAGTGT CAACACCAAGGTGGACAAGAAAGTTGAGCCCA SEQ ID NO: 1942 AATCTTGTGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAACTCCTGGGGGGACCGTCAG TCTTCCTCTTCCCCCCAAAACCCAAGGACACCCT CATGATCTCCCGGACCCCTGAGGTCACATGCGT GGTGGTGGACGTGAGCCACGAAGACCCTGAGGT CAAGTTCAACTGGTACGTGGACGGCGTGGAGGT GCATAATGCCAAGACAAAGCCGTGTGAGGAGC AGTACGGCAGCACGTACCGTTGTGTCAGCGTCC TCACCGTCCTGCACCAGGACTGGCTGAATGGCA AGGAGTACAAGTGCAAGGTCTCCAACAAAGCCC TCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTAC ACCCTGCCCCCATCCCGGGAGGAGATGACCAAG AACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC TTCTATCCCAGCGACATCGCCGTGGAGTGGGAG AGCAATGGGCAGCCGGAGAACAACTACAAGAC CACGCCTCCCGTGCTGGACTCCGACGGCTCCTTC TTCCTCTATAGCAAGCTCACCGTGGACAAGAGC AGGTGGCAGCAGGGGAACGTCTTCTCATGCTCC GTGATGCATGAGGCTCTGCACAACCACTACACG CAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2099 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG FTLTISSLQPEDFATYYCQQYDDLFTFGPGTKVDI RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYP TIFGVVLEYLGQGTLVTVSSASTKGPSVFPLAPSSK REAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS STSGGTAALGCLVKDYFPEPVTVSWNSGALTSGV STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR HTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVN GEC HKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGP SEQ ID NO: 372 SVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEV KFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSVL TVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAK GQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPS DIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKL TVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSL SPGK SEQ ID NO: 529 iPS:361095 6A5.004.004 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTGGGGGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTACCAACTATTTAA GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC AACTCCTGATCTACGATGCTTCCAATTTGGAGCC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC ATAATAAATACTATGCAGACGCCGTGAAGGGCC TGGGACAGATTTTACTTTCACCATCAGCAGCCTG GATTCACCATCTCCAGAGACAGTTCCAAGAACA CAGCCTGAAGATTTTGCAACATATTACTGTCAA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG CAGTATGATGATCTATTCACTTTCGGCCCTGGGA AGGACACGGCTGTGTATTACTGTGCGAGAGATC CCAAAGTGGATATCAAACGAACGGTGGCTGCAC GGACGATTTTTGGAGTGGTCCTTGAGTACTGGG CATCTGTCTTCATCTTCCCGCCATCTGATGAGCA GCCAGGGAACCCTGGTCACCGTCTCCTCAGCCT GTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTG CCACCAAGGGCCCATCGGTCTTCCCCCTGGCAC CTGAATAACTTCTATCCCAGAGAGGCCAAAGTA CCTCCTCCAAGAGCACCTCTGGGGGCACAGCGG CAGTGGAAGGTGGATAACGCCCTCCAATCGGGT CCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG AACTCCCAGGAGAGTGTCACAGAGCAGGACAG AACCGGTGACGGTGTCGTGGAACTCAGGCGCCC CAAGGACAGCACCTACAGCCTCAGCAGCACCCT TGACCAGCGGCGTGCACACCTTCCCGGCTGTCC GACGCTGAGCAAAGCAGACTACGAGAAACACA TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGT AAGTCTACGCCTGCGAAGTCACCCATCAGGGCC GGTGACCGTGCCCTCCAGCAGCTTGGGCACCCA TGAGCTCGCCCGTCACAAAGAGCTTCAACAGGG GACCTACATCTGCAACGTGAATCACAAGCCCAG GAGAGTGT CAACACCAAGGTGGACAAGAAAGTTGAGCCCA SEQ ID NO: 1943 AATCTTGTGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAACTCCTGGGGGGACCGTCAG TCTTCCTCTTCCCCCCAAAACCCAAGGACACCCT CATGATCTCCCGGACCCCTGAGGTCACATGCGT AGGTGGTGGACGTGAGCCACGAAGACCCTGAGGT CAAGTTCAACTGGTACGTGGACGGCGTGGAGGT GCATAATGCCAAGACAAAGCCGTGTGAGGAGC AGTACGGCAGCACGTACCGTTGTGTCAGCGTCC TCACCGTCCTGCACCAGGACTGGCTGAATGGCA AGGAGTACAAGTGCAAGGTCTCCAACAAAGCCC TCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTAC ACCCTGCCCCCATCCCGGGAGGAGATGACCAAG AACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC TTCTATCCCAGCGACATCGCCGTGGAGTGGGAG AGCAATGGGCAGCCGGAGAACAACTACAAGAC CACGCCTCCCGTGCTGGACTCCGACGGCTCCTTC TTCCTCTATAGCAAGCTCACCGTGGACAAGAGC AGGTGGCAGCAGGGGAACGTCTTCTCATGCTCC GTGATGCATGAGGCTCTGCACAACCACTACACG CAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2100 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG FTFTISSLQPEDFATYYCQQYDDLFTFGPGTKVDIK RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE TIFGVVLEYWGQGTLVTVSSASTKGPSVFPLAPSS AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSS KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG TLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV GEC NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG SEQ ID NO: 373 GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 530 iPS:361101 6A5.004.005 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTGGGGGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTACCAACTATTTAA GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC AACTCCTGATCTACGATGCTTCCAATTTGGAGCC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC ATAATAAATACTATGCAGACGCCGTGAAGGGCC TGGGACAGATTTTACTCTCACCATCAGCAGCCT GATTCACCATCTCCAGAGACAGTTCCAAGAACA GCAGCCTGAAGATATTGCAACATATTACTGTCA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGTATGATGATCTATTCACTTTCGGCCCTGGG AGGACACGGCTGTGTATTACTGTGCGAGAGATC ACCAAAGTGGATATCAAACGAACGGTGGCTGCA GGACGATTTTTGGAGTGGTCCTTGAGTACCTCG CCATCTGTCTTCATCTTCCCGCCATCTGATGAGC GCCAGGGAACCCTGGTCACCGTCTCCTCAGCCT AGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCT CCACCAAGGGCCCATCGGTCTTCCCCCTGGCAC GCTGAATAACTTCTATCCCAGAGAGGCCAAAGT CCTCCTCCAAGAGCACCTCTGGGGGCACAGCGG ACAGTGGAAGGTGGATAACGCCCTCCAATCGGG CCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG TAACTCCCAGGAGAGTGTCACAGAGCAGGACAG AACCGGTGACGGTGTCGTGGAACTCAGGCGCCC CAAGGACAGCACCTACAGCCTCAGCAGCACCCT TGACCAGCGGCGTGCACACCTTCCCGGCTGTCC GACGCTGAGCAAAGCAGACTACGAGAAACACA TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGT AAGTCTACGCCTGCGAAGTCACCCATCAGGGCC GGTGACCGTGCCCTCCAGCAGCTTGGGCACCCA TGAGCTCGCCCGTCACAAAGAGCTTCAACAGGG GACCTACATCTGCAACGTGAATCACAAGCCCAG GAGAGTGT CAACACCAAGGTGGACAAGAAAGTTGAGCCCA SEQ ID NO: 1944 AATCTTGTGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAACTCCTGGGGGGACCGTCAG TCTTCCTCTTCCCCCCAAAACCCAAGGACACCCT CATGATCTCCCGGACCCCTGAGGTCACATGCGT GGTGGTGGACGTGAGCCACGAAGACCCTGAGGT CAAGTTCAACTGGTACGTGGACGGCGTGGAGGT GCATAATGCCAAGACAAAGCCGTGTGAGGAGC AGTACGGCAGCACGTACCGTTGTGTCAGCGTCC TCACCGTCCTGCACCAGGACTGGCTGAATGGCA AGGAGTACAAGTGCAAGGTCTCCAACAAAGCCC TCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTAC ACCCTGCCCCCATCCCGGGAGGAGATGACCAAG AAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC TTCTATCCCAGCGACATCGCCGTGGAGTGGGAG AGCAATGGGCAGCCGGAGAACAACTACAAGAC CACGCCTCCCGTGCTGGACTCCGACGGCTCCTTC TTCCTCTATAGCAAGCTCACCGTGGACAAGAGC AGGTGGCAGCAGGGGAACGTCTTCTCATGCTCC GTGATGCATGAGGCTCTGCACAACCACTACACG CAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2101 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG FTLTISSLQPEDIATYYCQQYDDLFTFGPGTKVDIK RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE TIFGVVLEYLGQGTLVTVSSASTKGPSVFPLAPSSK AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSS STSGGTAALGCLVKDYFPEPVTVSWNSGALTSGV TLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR HTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVN GEC HKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGP SEQ ID NO: 374 SVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEV KFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSVL TVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAK GQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPS DIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKL TVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSL SPGK SEQ ID NO: 531 iPS:361105 6A5.004.006 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTGGGGGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTACCAACTATTTAA GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC AACTCCTGATCTACGATGCTTCCAATTTGGAGCC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC ATAATAAATACTATGCAGACGCCGTGAAGGGCC TGGGACAGATTTTACTTTCACCATCAGCAGCCTG GATTCACCATCTCCAGAGACAGTTCCAAGAACA CAGCCTGAAGATTTTGCAACATATTACTGTCAA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG CAGTATGATGATCTATTCACTTTCGGCCCTGGGA AGGACACGGCTGTGTATTACTGTGCGAGAGATC CCAAAGTGGATATCAAACGAACGGTGGCTGCAC GGACGATTTTTGGAGTGGTCCTTGAGTACCTCG CATCTGTCTTCATCTTCCCGCCATCTGATGAGCA GCCAGGGAACCCTGGTCACCGTCTCCTCAGCCT GTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTG CCACCAAGGGCCCATCGGTCTTCCCCCTGGCAC CTGAATAACTTCTATCCCAGAGAGGCCAAAGTA CCTCCTCCAAGAGCACCTCTGGGGGCACAGCGG CAGTGGAAGGTGGATAACGCCCTCCAATCGGGT CCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG AACTCCCAGGAGAGTGTCACAGAGCAGGACAG AACCGGTGACGGTGTCGTGGAACTCAGGCGCCC CAAGGACAGCACCTACAGCCTCAGCAGCACCCT TGACCAGCGGCGTGCACACCTTCCCGGCTGTCC GACGCTGAGCAAAGCAGACTACGAGAAACACA TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGT AAGTCTACGCCTGCGAAGTCACCCATCAGGGCC GGTGACCGTGCCCTCCAGCAGCTTGGGCACCCA TGAGCTCGCCCGTCACAAAGAGCTTCAACAGGG GACCTACATCTGCAACGTGAATCACAAGCCCAG GAGAGTGT CAACACCAAGGTGGACAAGAAAGTTGAGCCCA SEQ ID NO: 1945 AATCTTGTGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAACTCCTGGGGGGACCGTCAG TCTTCCTCTTCCCCCCAAAACCCAAGGACACCCT CATGATCTCCCGGACCCCTGAGGTCACATGCGT GGTGGTGGACGTGAGCCACGAAGACCCTGAGGT CAAGTTCAACTGGTACGTGGACGGCGTGGAGGT GCATAATGCCAAGACAAAGCCGTGTGAGGAGC AGTACGGCAGCACGTACCGTTGTGTCAGCGTCC TCACCGTCCTGCACCAGGACTGGCTGAATGGCA AGGAGTACAAGTGCAAGGTCTCCAACAAAGCCC TCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTAC ACCCTGCCCCCATCCCGGGAGGAGATGACCAAG AACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC TTCTATCCCAGCGACATCGCCGTGGAGTGGGAG AGCAATGGGCAGCCGGAGAACAACTACAAGAC CACGCCTCCCGTGCTGGACTCCGACGGCTCCTTC TTCCTCTATAGCAAGCTCACCGTGGACAAGAGC AGGTGGCAGCAGGGGAACGTCTTCTCATGCTCC GTGATGCATGAGGCTCTGCACAACCACTACACG CAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2102 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG FTFTISSLQPEDFATYYCQQYDDLFTFGPGTKVDIK RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE TIFGVVLEYLGQGTLVTVSSASTKGPSVFPLAPSSK AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSS STSGGTAALGCLVKDYFPEPVTVSWNSGALTSGV TLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR HTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVN GEC HKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGP SEQ ID NO: 375 SVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEV KFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSVL TVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAK GQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPS DIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKL TVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSL SPGK SEQ ID NO: 532 iPS:361109 6A5.004.007 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTGGGGGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTACCAACTATTTAA GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC AACTCCTGATCTACGATGCTTCCAATTTGGAGCC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC ATAATAAATACTATGCAGACGCCGTGAAGGGCC TGGGACAGATTTTACTTTCACCATCAGCAGCCTG GATTCACCATCTCCAGAGACAGTTCCAAGAACA CAGCCTGAAGATATTGCAACATATTACTGTCAA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG CAGTATGATGATCTATTCACTTTCGGCCCTGGGA AGGACACGGCTGTGTATTACTGTGCGAGAGATC CCAAAGTGGATATCAAACGAACGGTGGCTGCAC GGACGATTTTTGGAGTGGTCCTTGAGTACTGGG CATCTGTCTTCATCTTCCCGCCATCTGATGAGCA GCCAGGGAACCCTGGTCACCGTCTCCTCAGCCT GTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTG CCACCAAGGGCCCATCGGTCTTCCCCCTGGCAC CTGAATAACTTCTATCCCAGAGAGGCCAAAGTA CCTCCTCCAAGAGCACCTCTGGGGGCACAGCGG CAGTGGAAGGTGGATAACGCCCTCCAATCGGGT CCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG AACTCCCAGGAGAGTGTCACAGAGCAGGACAG AACCGGTGACGGTGTCGTGGAACTCAGGCGCCC CAAGGACAGCACCTACAGCCTCAGCAGCACCCT TGACCAGCGGCGTGCACACCTTCCCGGCTGTCC GACGCTGAGCAAAGCAGACTACGAGAAACACA TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGT AAGTCTACGCCTGCGAAGTCACCCATCAGGGCC GGTGACCGTGCCCTCCAGCAGCTTGGGCACCCA TGAGCTCGCCCGTCACAAAGAGCTTCAACAGGG GACCTACATCTGCAACGTGAATCACAAGCCCAG GAGAGTGT CAACACCAAGGTGGACAAGAAAGTTGAGCCCA SEQ ID NO: 1946 AATCTTGTGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAACTCCTGGGGGGACCGTCAG TCTTCCTCTTCCCCCCAAAACCCAAGGACACCCT CATGATCTCCCGGACCCCTGAGGTCACATGCGT GGTGGTGGACGTGAGCCACGAAGACCCTGAGGT CAAGTTCAACTGGTACGTGGACGGCGTGGAGGT GCATAATGCCAAGACAAAGCCGTGTGAGGAGC AGTACGGCAGCACGTACCGTTGTGTCAGCGTCC TCACCGTCCTGCACCAGGACTGGCTGAATGGCA AGGAGTACAAGTGCAAGGTCTCCAACAAAGCCC TCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTAC ACCCTGCCCCCATCCCGGGAGGAGATGACCAAG AACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC TTCTATCCCAGCGACATCGCCGTGGAGTGGGAG AGCAATGGGCAGCCGGAGAACAACTACAAGAC CACGCCTCCCGTGCTGGACTCCGACGGCTCCTTC TTCCTCTATAGCAAGCTCACCGTGGACAAGAGC AGGTGGCAGCAGGGGAACGTCTTCTCATGCTCC GTGATGCATGAGGCTCTGCACAACCACTACACG CAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2103 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG FTFTISSLQPEDIATYYCQQYDDLFTFGPGTKVDIK RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE TIFGVVLEYWGQGTLVTVSSASTKGPSVFPLAPSS AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSS KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG TLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV GEC NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG SEQ ID NO: 376 GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV ALTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 533 iPS:361113 6A5.004.008 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTGGGGGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTACCAACTATTTAA GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC AACTCCTGATCTACGATGCTTCCAATTTGGAGCC TGGAGTGGGTGGCAGCTATATGGTATGATGGAA AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC ATAATAAATACTATGCAGACGCCGTGAAGGGCC TGGGACAGATTTTACTCTCACCATCAGCAGCCT GATTCACCATCTCCAGAGACAGTTCCAAGAACA GCAGCCTGAAGATTTTGCAACATATTACTGTCA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGTATGATGATCTATTCACTTTCGGCCCTGGG AGGACACGGCTGTGTATTACTGTGCGAGAGATC ACCAAAGTGGATATCAAACGAACGGTGGCTGCA GGACGATTTTTGGAGTGGTCCTTGAGTACTGGG CCATCTGTCTTCATCTTCCCGCCATCTGATGAGC GCCAGGGAACCCTGGTCACCGTCTCCTCAGCCT AGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCT CCACCAAGGGCCCATCGGTCTTCCCCCTGGCAC GCTGAATAACTTCTATCCCAGAGAGGCCAAAGT CCTCCTCCAAGAGCACCTCTGGGGGCACAGCGG ACAGTGGAAGGTGGATAACGCCCTCCAATCGGG CCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG TAACTCCCAGGAGAGTGTCACAGAGCAGGACAG AACCGGTGACGGTGTCGTGGAACTCAGGCGCCC CAAGGACAGCACCTACAGCCTCAGCAGCACCCT TGACCAGCGGCGTGCACACCTTCCCGGCTGTCC GACGCTGAGCAAAGCAGACTACGAGAAACACA TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGT AAGTCTACGCCTGCGAAGTCACCCATCAGGGCC GGTGACCGTGCCCTCCAGCAGCTTGGGCACCCA TGAGCTCGCCCGTCACAAAGAGCTTCAACAGGG GACCTACATCTGCAACGTGAATCACAAGCCCAG GAGAGTGT CAACACCAAGGTGGACAAGAAAGTTGAGCCCA SEQ ID NO: 1947 AATCTTGTGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAACTCCTGGGGGGACCGTCAG TCTTCCTCTTCCCCCCAAAACCCAAGGACACCCT CATGATCTCCCGGACCCCTGAGGTCACATGCGT GGTGGTGGACGTGAGCCACGAAGACCCTGAGGT CAAGTTCAACTGGTACGTGGACGGCGTGGAGGT GCATAATGCCAAGACAAAGCCGTGTGAGGAGC AGTACGGCAGCACGTACCGTTGTGTCAGCGTCC TCACCGTCCTGCACCAGGACTGGCTGAATGGCA AGGAGTACAAGTGCAAGGTCTCCAACAAAGCCC TCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTAC ACCCTGCCCCCATCCCGGGAGGAGATGACCAAG AACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC TTCTATCCCAGCGACATCGCCGTGGAGTGGGAG AGCAATGGGCAGCCGGAGAACAACTACAAGAC CACGCCTCCCGTGCTGGACTCCGACGGCTCCTTC TTCCTCTATAGCAAGCTCACCGTGGACAAGAGC AGGTGGCAGCAGGGGAACGTCTTCTCATGCTCC GTGATGCATGAGGCTCTGCACAACCACTACACG CAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2104 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD HWVRQPPGKGLEWVAAIWYDGNNKYYADAVKG FTLTISSLQPEDFATYYCQQYDDLFTFGPGTKVDIK RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE TIFGVVLEYWGQGTLVTVSSASTKGPSVFPLAPSS AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSS KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG TLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV GEC NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG SEQ ID NO: 377 GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 534 iPS:361120 6A5.004.009 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTGGGGGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTACCAACTATTTAA GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA AATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC AACTCCTGATCTACGATGCTTCCAATTTGGAGCC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC ATAATAAATACTATGCAGACTCCGTGAAGGGCC TGGGACAGATTTTACTCTCACCATCAGCAGCCT GATTCACCATCTCCAGAGACAGTTCCAAGAACA GCAGCCTGAAGATTTTGCAACATATTACTGTCA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGTATGATGATCTATTCACTTTCGGCCCTGGG AGGACACGGCTGTGTATTACTGTGCGAGAGATC ACCAAAGTGGATATCAAACGAACGGTGGCTGCA GGACGATTTTTGGAGTGGTCCTTGAGTACTGGG CCATCTGTCTTCATCTTCCCGCCATCTGATGAGC GCCAGGGAACCCTGGTCACCGTCTCCTCAGCCT AGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCT CCACCAAGGGCCCATCGGTCTTCCCCCTGGCAC GCTGAATAACTTCTATCCCAGAGAGGCCAAAGT CCTCCTCCAAGAGCACCTCTGGGGGCACAGCGG ACAGTGGAAGGTGGATAACGCCCTCCAATCGGG CCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG TAACTCCCAGGAGAGTGTCACAGAGCAGGACAG AACCGGTGACGGTGTCGTGGAACTCAGGCGCCC CAAGGACAGCACCTACAGCCTCAGCAGCACCCT TGACCAGCGGCGTGCACACCTTCCCGGCTGTCC GACGCTGAGCAAAGCAGACTACGAGAAACACA TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGT AAGTCTACGCCTGCGAAGTCACCCATCAGGGCC GGTGACCGTGCCCTCCAGCAGCTTGGGCACCCA TGAGCTCGCCCGTCACAAAGAGCTTCAACAGGG GACCTACATCTGCAACGTGAATCACAAGCCCAG GAGAGTGT CAACACCAAGGTGGACAAGAAAGTTGAGCCCA SEQ ID NO: 1948 AATCTTGTGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAACTCCTGGGGGGACCGTCAG TCTTCCTCTTCCCCCCAAAACCCAAGGACACCCT CATGATCTCCCGGACCCCTGAGGTCACATGCGT GGTGGTGGACGTGAGCCACGAAGACCCTGAGGT CAAGTTCAACTGGTACGTGGACGGCGTGGAGGT GCATAATGCCAAGACAAAGCCGTGTGAGGAGC AGTACGGCAGCACGTACCGTTGTGTCAGCGTCC TCACCGTCCTGCACCAGGACTGGCTGAATGGCA AGGAGTACAAGTGCAAGGTCTCCAACAAAGCCC TCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTAC ACCCTGCCCCCATCCCGGGAGGAGATGACCAAG AACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC TTCTATCCCAGCGACATCGCCGTGGAGTGGGAG AGCAATGGGCAGCCGGAGAACAACTACAAGAC CACGCCTCCCGTGCTGGACTCCGACGGCTCCTTC TTCCTCTATAGCAAGCTCACCGTGGACAAGAGC AGGTGGCAGCAGGGGAACGTCTTCTCATGCTCC GTGATGCATGAGGCTCTGCACAACCACTACACG CAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2105 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD HWVRQPPGKGLEWVAAIWYDANNKYYADSVKG FTLTISSLQPEDFATYYCQQYDDLFTFGPGTKVDIK RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE TIFGVVLEYWGQGTLVTVSSASTKGPSVFPLAPSS AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSS KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG TLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV GEC NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG SEQ ID NO: 378 GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 535 iPS:359896 6A5.004.010 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTGGGGGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTACCAACTATTTAA GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC AACTCCTGATCTACGATGCTTCCAATTTGGAGCC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC ATAATAAATACTATGCAGACGCCGTGAAGGGCC TGGGACAGATTTTACTCTCACCATCAGCAGCCT GATTCACCATCTCCAGAGACAGTTCCAAGAACA GCAGCCTGAAGATTTTGCAACATATTACTGTCA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGTATGATGATCTATTCACTTTCGGCCAAGG AGGACACGGCTGTGTATTACTGTGCGAGAGATC GACCAAAGTGGATATCAAACGAACGGTGGCTGC GGACGATTTTTGGAGTGGTCCTTGAGTACTGGG ACCATCTGTCTTCATCTTCCCGCCATCTGATGAG GCCAGGGAACCCTGGTCACCGTCTCCTCAGCCT CAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCC CCACCAAGGGCCCATCGGTCTTCCCCCTGGCAC ATGCTGAATAACTTCTATCCCAGAGAGGCCAAAG CCTCCTCCAAGAGCACCTCTGGGGGCACAGCGG TACAGTGGAAGGTGGATAACGCCCTCCAATCGG CCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG GTAACTCCCAGGAGAGTGTCACAGAGCAGGACA AACCGGTGACGGTGTCGTGGAACTCAGGCGCCC GCAAGGACAGCACCTACAGCCTCAGCAGCACCC TGACCAGCGGCGTGCACACCTTCCCGGCTGTCC TGACGCTGAGCAAAGCAGACTACGAGAAACAC TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGT AAAGTCTACGCCTGCGAAGTCACCCATCAGGGC GGTGACCGTGCCCTCCAGCAGCTTGGGCACCCA CTGAGCTCGCCCGTCACAAAGAGCTTCAACAGG GACCTACATCTGCAACGTGAATCACAAGCCCAG GGAGAGTGT CAACACCAAGGTGGACAAGAAAGTTGAGCCCA SEQ ID NO: 1949 AATCTTGTGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAACTCCTGGGGGGACCGTCAG TCTTCCTCTTCCCCCCAAAACCCAAGGACACCCT CATGATCTCCCGGACCCCTGAGGTCACATGCGT GGTGGTGGACGTGAGCCACGAAGACCCTGAGGT CAAGTTCAACTGGTACGTGGACGGCGTGGAGGT GCATAATGCCAAGACAAAGCCGTGTGAGGAGC AGTACGGCAGCACGTACCGTTGTGTCAGCGTCC TCACCGTCCTGCACCAGGACTGGCTGAATGGCA AGGAGTACAAGTGCAAGGTCTCCAACAAAGCCC TCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTAC ACCCTGCCCCCATCCCGGGAGGAGATGACCAAG AACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC TTCTATCCCAGCGACATCGCCGTGGAGTGGGAG AGCAATGGGCAGCCGGAGAACAACTACAAGAC CACGCCTCCCGTGCTGGACTCCGACGGCTCCTTC TTCCTCTATAGCAAGCTCACCGTGGACAAGAGC AGGTGGCAGCAGGGGAACGTCTTCTCATGCTCC GTGATGCATGAGGCTCTGCACAACCACTACACG CAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2106 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG FTLTISSLQPEDFATYYCQQYDDLFTFGQGTKVDI RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR TIFGVVLEYWGQGTLVTVSSASTKGPSVFPLAPSS EAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV RGEC NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG SEQ ID NO: 379 GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 536 iPS:359890 6A5.004.011 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTGGGGGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCAGGCGAGTCAGGACATTACCAACTATTTAA GCAGCGTCTGGATTCTCCTTCAGTAGCTATGGCA ATTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGCCTCCAGGCAAGGGGC AACTCCTGATCTACGATGCTTCCAATTTGGAGCC TGGAGTGGGTGGCAGCTATATGGTATGATGCAA AGGGGTCCCATCAAGGTTCAGTGGAAGTGGATC ATAATAAATACTATGCAGACGCCGTGAAGGGCC TGGGACAGATTTTACTCTCACCATCAGCAGCCT GATTCACCATCTCCAGAGACAGTTCCAAGAACA GCAGCCTGAAGATTTTGCAACATATTACTGTCA CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGTATGATGATCTATTCACTTTCGGCCAAGG AGGACACGGCTGTGTATTACTGTGCGAGAGATC GACCAAAGTGGATATCAAACGAACGGTGGCTGC GGACGATTTTTGGAGTGGTCCTTGAGTACCTCG ACCATCTGTCTTCATCTTCCCGCCATCTGATGAG GCCAGGGAACCCTGGTCACCGTCTCCTCAGCCT CAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCC CCACCAAGGGCCCATCGGTCTTCCCCCTGGCAC TGCTGAATAACTTCTATCCCAGAGAGGCCAAAG CCTCCTCCAAGAGCACCTCTGGGGGCACAGCGG TACAGTGGAAGGTGGATAACGCCCTCCAATCGG CCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG GTAACTCCCAGGAGAGTGTCACAGAGCAGGACA AACCGGTGACGGTGTCGTGGAACTCAGGCGCCC GCAAGGACAGCACCTACAGCCTCAGCAGCACCC TGACCAGCGGCGTGCACACCTTCCCGGCTGTCC TGACGCTGAGCAAAGCAGACTACGAGAAACAC TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGT AAAGTCTACGCCTGCGAAGTCACCCATCAGGGC GGTGACCGTGCCCTCCAGCAGCTTGGGCACCCA CTGAGCTCGCCCGTCACAAAGAGCTTCAACAGG GACCTACATCTGCAACGTGAATCACAAGCCCAG GGAGAGTGT CAACACCAAGGTGGACAAGAAAGTTGAGCCCA SEQ ID NO: 1950 AATCTTGTGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAACTCCTGGGGGGACCGTCAG TCTTCCTCTTCCCCCCAAAACCCAAGGACACCCT CATGATCTCCCGGACCCCTGAGGTCACATGCGT GGTGGTGGACGTGAGCCACGAAGACCCTGAGGT CAAGTTCAACTGGTACGTGGACGGCGTGGAGGT GCATAATGCCAAGACAAAGCCGTGTGAGGAGC AGTACGGCAGCACGTACCGTTGTGTCAGCGTCC TCACCGTCCTGCACCAGGACTGGCTGAATGGCA AGGAGTACAAGTGCAAGGTCTCCAACAAAGCCC TCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTAC ACCCTGCCCCCATCCCGGGAGGAGATGACCAAG AACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC TTCTATCCCAGCGACATCGCCGTGGAGTGGGAG AGCAATGGGCAGCCGGAGAACAACTACAAGAC CACGCCTCCCGTGCTGGACTCCGACGGCTCCTTC TTCCTCTATAGCAAGCTCACCGTGGACAAGAGC AGGTGGCAGCAGGGGAACGTCTTCTCATGCTCC GTGATGCATGAGGCTCTGCACAACCACTACACG CAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2107 AA DIQMTQSPSSLSASVGDRVTITCQASQDITNYLNW QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM YQQKPGKAPKLLIYDASNLEPGVPSRFSGSGSGTD HWVRQPPGKGLEWVAAIWYDANNKYYADAVKG FTLTISSLQPEDFATYYCQQYDDLFTFGQGTKVDI RFTISRDSSKNTLYLQMNSLRAEDTAVYYCARDR KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR TIFGVVLEYLGQGTLVTVSSASTKGPSVFPLAPSSK EAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS STSGGTAALGCLVKDYFPEPVTVSWNSGALTSGV STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN HTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVN RGEC HKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGP SEQ ID NO: 380 SVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEV KFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSVL TVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAK GQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPS DIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKL TVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSL SPGK SEQ ID NO: 537 iPS:359567 2A11.002 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGGGCCAGTCAGATTTTTACCAGCACCTACT GCAGCGTCTGGATTCAGTTTCAGTAGCTATGGC TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGA CCAGGCTCCTCATCTATGGTGCATCCAGCAGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG AGTAATAAATACTATGAAGACGCCGTGAAGGGC GGTCTGGGACAGACTTCACTCTCACCATCAGCA CGATTCACCATCTCCAGAGACAATTCCAAGAAC GATTGGAGCCTGAAGATTTTGCAGTGTATTACT ACGCTGTTTCTGCAAGTGAACAGCCTGAGAGCC GTCAGCAGTATGGTAGCTCACCTCGCTTCGGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGGG AAGGGACACGACTGGAGATTAAACGAACGGTG ATTACGATTTTTGGTCATGGGTTTGAATATTGGG GCTGCACCATCTGTCTTCATCTTCCCGCCATCTG GCCAGGGAACCCTGGTCACCGTCTCCTCAGCCT ATGAGCAGTTGAAATCTGGAACTGCCTCTGTTG CCACCAAGGGCCCATCGGTCTTCCCCCTGGCAC TGTGCCTGCTGAATAACTTCTATCCCAGAGAGG CCTCCTCCAAGAGCACCTCTGGGGGCACAGCGG CCAAAGTACAGTGGAAGGTGGATAACGCCCTCC CCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG AATCGGGTAACTCCCAGGAGAGTGTCACAGAGC AACCGGTGACGGTGTCGTGGAACTCAGGCGCCC AGGACAGCAAGGACAGCACCTACAGCCTCAGC TGACCAGCGGCGTGCACACCTTCCCGGCTGTCC AGCACCCTGACGCTGAGCAAAGCAGACTACGAG TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGT AAACACAAAGTCTACGCCTGCGAAGTCACCCAT GGTGACCGTGCCCTCCAGCAGCTTGGGCACCCA CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTC GACCTACATCTGCAACGTGAATCACAAGCCCAG AACAGGGGAGAGTGT CAACACCAAGGTGGACAAGAAAGTTGAGCCCA SEQ ID NO: 1951 AATCTTGTGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAACTCCTGGGGGGACCGTCAG TCTTCCTCTTCCCCCCAAAACCCAAGGACACCCT CATGATCTCCCGGACCCCTGAGGTCACATGCGT GGTGGTGGACGTGAGCCACGAAGACCCTGAGGT CAAGTTCAACTGGTACGTGGACGGCGTGGAGGT GCATAATGCCAAGACAAAGCCGTGTGAGGAGC AGTACGGCAGCACGTACCGTTGTGTCAGCGTCC TCACCGTCCTGCACCAGGACTGGCTGAATGGCA AGGAGTACAAGTGCAAGGTCTCCAACAAAGCCC ATCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTAC ACCCTGCCCCCATCCCGGGAGGAGATGACCAAG AACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC TTCTATCCCAGCGACATCGCCGTGGAGTGGGAG AGCAATGGGCAGCCGGAGAACAACTACAAGAC CACGCCTCCCGTGCTGGACTCCGACGGCTCCTTC TTCCTCTATAGCAAGCTCACCGTGGACAAGAGC AGGTGGCAGCAGGGGAACGTCTTCTCATGCTCC GTGATGCATGAGGCTCTGCACAACCACTACACG CAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2108 AA EIVLTQSPGTLSLSPGERATLSCRASQIFTSTYLAW QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF HWVRQAPGKGLEWVAVIWYDASNKYYEDAVKG TLTISRLEPEDFAVYYCQQYGSSPRFGQGTRLEIKR RFTISRDNSKNTLFLQVNSLRAEDTAVYYCARGITI TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA FGHGFEYWGQGTLVTVSSASTKGPSVFPLAPSSKS KVQWKVDNALQSGNSQESVTEQDSKDSTYSLSST TSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVH LTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG TFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNH EC KPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPS SEQ ID NO: 381 VFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVK FNWYVDGVEVHNAKTKPCEEQYGSTYRCVSVLT VLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKG QPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSD IAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLT VDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP GK SEQ ID NO: 538 iPS:335965 2A11.003 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGGGCCAGTCAGATTTTTACCAGCACCTACT GCAGCGTCTGGATTCAGTTTCAGTAGCTATGGC TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGA CCAGGCTCCTCATCTATGGTGCATCCAGCAGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGGA CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG AGTAATAAATACTATGAAGACTCCGTGAAGGGC GGTCTGGGACAGACTTCACTCTCACCATCAGCA CGATTCACCATCTCCAGAGACAATTCCAAGAAC GATTGGAGCCTGAAGATTTTGCAGTGTATTACT ACGCTGTTTCTGCAAGTGAACAGCCTGAGAGCC GTCAGCAGTATGGTAGCTCACCTCGCTTCGGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGGG AAGGGACACGACTGGAGATTAAACGAACGGTG ATTACGATTTTTGGTCATGGGTTTGAATATTGGG GCTGCACCATCTGTCTTCATCTTCCCGCCATCTG GCCAGGGAACCCTGGTCACCGTCTCCTCAGCCT ATGAGCAGTTGAAATCTGGAACTGCCTCTGTTG CCACCAAGGGCCCATCGGTCTTCCCCCTGGCAC TGTGCCTGCTGAATAACTTCTATCCCAGAGAGG CCTCCTCCAAGAGCACCTCTGGGGGCACAGCGG CCAAAGTACAGTGGAAGGTGGATAACGCCCTCC CCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG AATCGGGTAACTCCCAGGAGAGTGTCACAGAGC AACCGGTGACGGTGTCGTGGAACTCAGGCGCCC AGGACAGCAAGGACAGCACCTACAGCCTCAGC TGACCAGCGGCGTGCACACCTTCCCGGCTGTCC AGCACCCTGACGCTGAGCAAAGCAGACTACGAG TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGT AAACACAAAGTCTACGCCTGCGAAGTCACCCAT GGTGACCGTGCCCTCCAGCAGCTTGGGCACCCA CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTC GACCTACATCTGCAACGTGAATCACAAGCCCAG AACAGGGGAGAGTGT CAACACCAAGGTGGACAAGAAAGTTGAGCCCA SEQ ID NO: 1952 AATCTTGTGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAACTCCTGGGGGGACCGTCAG TCTTCCTCTTCCCCCCAAAACCCAAGGACACCCT CATGATCTCCCGGACCCCTGAGGTCACATGCGT GGTGGTGGACGTGAGCCACGAAGACCCTGAGGT CAAGTTCAACTGGTACGTGGACGGCGTGGAGGT GCATAATGCCAAGACAAAGCCGTGTGAGGAGC AGTACGGCAGCACGTACCGTTGTGTCAGCGTCC TCACCGTCCTGCACCAGGACTGGCTGAATGGCA AGGAGTACAAGTGCAAGGTCTCCAACAAAGCCC TCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTAC ACCCTGCCCCCATCCCGGGAGGAGATGACCAAG AACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC TTCTATCCCAGCGACATCGCCGTGGAGTGGGAG AGCAATGGGCAGCCGGAGAACAACTACAAGAC CACGCCTCCCGTGCTGGACTCCGACGGCTCCTTC TTCCTCTATAGCAAGCTCACCGTGGACAAGAGC AGGTGGCAGCAGGGGAACGTCTTCTCATGCTCC AGTGATGCATGAGGCTCTGCACAACCACTACACG CAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2109 AA EIVLTQSPGTLSLSPGERATLSCRASQIFTSTYL QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM AWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGS HWVRQAPGKGLEWVAVIWYDGSNKYYEDSVKG GTDFTLTISRLEPEDFAVYYCQQYGSSPRFGQGT RFTISRDNSKNTLFLQVNSLRAEDTAVYYCARGITI RLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL FGHGFEYWGQGTLVTVSSASTKGPSVFPLAPSSKS NNFYPREAKVQWKVDNALQSGNSQESVTEQDSKD TSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVH STYSLSSTLTLSKADYEKHKVYACEVTHQGLSSP TFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNH VTKSFNRGEC KPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPS SEQ ID NO: 382 VFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVK FNWYVDGVEVHNAKTKPCEEQYGSTYRCVSVLT VLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKG QPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSD IAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLT VDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP GK SEQ ID NO: 539 iPS:361158 2A11.004 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGGGCCAGTCAGATTTTTACCAGCACCTACT GCAGCGTCTGGATTCAGTTTCAGTAGCTATGGC TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGA CCAGGCTCCTCATCTATGGTGCATCCAGCAGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGGA CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG AGTAATAAATACTATGAAGACGCCGTGAAGGGC GGTCTGGGACAGACTTCACTCTCACCATCAGCA CGATTCACCATCTCCAGAGACAATTCCAAGAAC GATTGGAGCCTGAAGATTTTGCAGTGTATTACT ACGCTGTTTCTGCAAGTGAACAGCCTGAGAGCC GTCAGCAGTATGGTAGCTCACCTCGCTTCGGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGGG AAGGGACACGACTGGAGATTAAACGAACGGTG ATTACGATTTTTGGTCATGGGTTTGAATATTGGG GCTGCACCATCTGTCTTCATCTTCCCGCCATCTG GCCAGGGAACCCTGGTCACCGTCTCCTCAGCCT ATGAGCAGTTGAAATCTGGAACTGCCTCTGTTG CCACCAAGGGCCCATCGGTCTTCCCCCTGGCAC TGTGCCTGCTGAATAACTTCTATCCCAGAGAGG CCTCCTCCAAGAGCACCTCTGGGGGCACAGCGG CCAAAGTACAGTGGAAGGTGGATAACGCCCTCC CCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG AATCGGGTAACTCCCAGGAGAGTGTCACAGAGC AACCGGTGACGGTGTCGTGGAACTCAGGCGCCC AGGACAGCAAGGACAGCACCTACAGCCTCAGC TGACCAGCGGCGTGCACACCTTCCCGGCTGTCC AGCACCCTGACGCTGAGCAAAGCAGACTACGAG TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGT AAACACAAAGTCTACGCCTGCGAAGTCACCCAT GGTGACCGTGCCCTCCAGCAGCTTGGGCACCCA CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTC GACCTACATCTGCAACGTGAATCACAAGCCCAG AACAGGGGAGAGTGT CAACACCAAGGTGGACAAGAAAGTTGAGCCCA SEQ ID NO: 1953 AATCTTGTGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAACTCCTGGGGGGACCGTCAG TCTTCCTCTTCCCCCCAAAACCCAAGGACACCCT CATGATCTCCCGGACCCCTGAGGTCACATGCGT GGTGGTGGACGTGAGCCACGAAGACCCTGAGGT CAAGTTCAACTGGTACGTGGACGGCGTGGAGGT GCATAATGCCAAGACAAAGCCGTGTGAGGAGC AGTACGGCAGCACGTACCGTTGTGTCAGCGTCC TCACCGTCCTGCACCAGGACTGGCTGAATGGCA AGGAGTACAAGTGCAAGGTCTCCAACAAAGCCC TCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTAC ACCCTGCCCCCATCCCGGGAGGAGATGACCAAG AACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC TTCTATCCCAGCGACATCGCCGTGGAGTGGGAG AGCAATGGGCAGCCGGAGAACAACTACAAGAC CACGCCTCCCGTGCTGGACTCCGACGGCTCCTTC TTCCTCTATAGCAAGCTCACCGTGGACAAGAGC AGGTGGCAGCAGGGGAACGTCTTCTCATGCTCC GTGATGCATGAGGCTCTGCACAACCACTACACG CAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2110 AA EIVLTQSPGTLSLSPGERATLSCRASQIFTSTYLAW QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF HWVRQAPGKGLEWVAVIWYDGSNKYYEDAVKG TLTISRLEPEDFAVYYCQQYGSSPRFGQGTRLEIKR RFTISRDNSKNTLFLQVNSLRAEDTAVYYCARGITI TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA FGHGFEYWGQGTLVTVSSASTKGPSVFPLAPSSKS KVQWKVDNALQSGNSQESVTEQDSKDSTYSLSST ATSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVH LTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG TFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNH EC KPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPS SEQ ID NO: 383 VFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVK FNWYVDGVEVHNAKTKPCEEQYGSTYRCVSVLT VLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKG QPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSD IAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLT VDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP GK SEQ ID NO: 540 iPS:361165 2A11.005 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCAGGGCCAGTCAGATTTTTACCAGCACCTACT GCAGCGTCTGGATTCAGTTTCAGTAGCTATGGC TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGA CCAGGCTCCTCATCTATGGTGCATCCAGCAGGG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG AGTAATAAATACTATGAAGACTCCGTGAAGGGC GGTCTGGGACAGACTTCACTCTCACCATCAGCA CGATTCACCATCTCCAGAGACAATTCCAAGAAC GATTGGAGCCTGAAGATTTTGCAGTGTATTACT ACGCTGTTTCTGCAAGTGAACAGCCTGAGAGCC GTCAGCAGTATGGTAGCTCACCTCGCTTCGGCC GAGGACACGGCTGTGTATTACTGTGCGAGAGGG AAGGGACACGACTGGAGATTAAACGAACGGTG ATTACGATTTTTGGTCATGGGTTTGAATATTGGG GCTGCACCATCTGTCTTCATCTTCCCGCCATCTG GCCAGGGAACCCTGGTCACCGTCTCCTCAGCCT ATGAGCAGTTGAAATCTGGAACTGCCTCTGTTG CCACCAAGGGCCCATCGGTCTTCCCCCTGGCAC TGTGCCTGCTGAATAACTTCTATCCCAGAGAGG CCTCCTCCAAGAGCACCTCTGGGGGCACAGCGG CCAAAGTACAGTGGAAGGTGGATAACGCCCTCC CCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG AATCGGGTAACTCCCAGGAGAGTGTCACAGAGC AACCGGTGACGGTGTCGTGGAACTCAGGCGCCC AGGACAGCAAGGACAGCACCTACAGCCTCAGC TGACCAGCGGCGTGCACACCTTCCCGGCTGTCC AGCACCCTGACGCTGAGCAAAGCAGACTACGAG TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGT AAACACAAAGTCTACGCCTGCGAAGTCACCCAT GGTGACCGTGCCCTCCAGCAGCTTGGGCACCCA CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTC GACCTACATCTGCAACGTGAATCACAAGCCCAG AACAGGGGAGAGTGT CAACACCAAGGTGGACAAGAAAGTTGAGCCCA SEQ ID NO: 1954 AATCTTGTGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAACTCCTGGGGGGACCGTCAG TCTTCCTCTTCCCCCCAAAACCCAAGGACACCCT CATGATCTCCCGGACCCCTGAGGTCACATGCGT GGTGGTGGACGTGAGCCACGAAGACCCTGAGGT CAAGTTCAACTGGTACGTGGACGGCGTGGAGGT GCATAATGCCAAGACAAAGCCGTGTGAGGAGC AGTACGGCAGCACGTACCGTTGTGTCAGCGTCC TCACCGTCCTGCACCAGGACTGGCTGAATGGCA AGGAGTACAAGTGCAAGGTCTCCAACAAAGCCC TCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTAC ACCCTGCCCCCATCCCGGGAGGAGATGACCAAG AACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC TTCTATCCCAGCGACATCGCCGTGGAGTGGGAG AGCAATGGGCAGCCGGAGAACAACTACAAGAC CACGCCTCCCGTGCTGGACTCCGACGGCTCCTTC TTCCTCTATAGCAAGCTCACCGTGGACAAGAGC AGGTGGCAGCAGGGGAACGTCTTCTCATGCTCC GTGATGCATGAGGCTCTGCACAACCACTACACG CAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2111 AA EIVLTQSPGTLSLSPGERATLSCRASQIFTSTYLAW QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYGM YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF HWVRQAPGKGLEWVAVIWYDASNKYYEDSVKG TLTISRLEPEDFAVYYCQQYGSSPRFGQGTRLEIKR RFTISRDNSKNTLFLQVNSLRAEDTAVYYCARGITI TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA FGHGFEYWGQGTLVTVSSASTKGPSVFPLAPSSKS KVQWKVDNALQSGNSQESVTEQDSKDSTYSLSST TSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVH LTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG TFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNH EC KPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPS SEQ ID NO: 384 VFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVK FNWYVDGVEVHNAKTKPCEEQYGSTYRCVSVLT VLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKG QPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSD IAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLT VDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP GK SEQ ID NO: 541 iPS:361172 2G10_LC1.003 NA GAAATAGTGATGACGCAGTCTCCAGCCACCCTG CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCAGCATCTGGATTCACCTTCAGTAACTATGGC GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC ATGCACTGGGTCCGCCAGGCTCCAGGCGAGGGG AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC CTGGAGTGGGTGGCAGCTATATGGTTTGATGCA ACTGGTATCCCAGCCAGGTTCAGTGGCAGTGGG AGTGATAAATACTATGCAGACGCCGTGAAGGGC TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC CTGCAGTCTGAAGATTTTGCAGTTTATTACTGTC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC AGCAGTATAATAACTGGCCTCTCACTTTCGGCG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GAGGGACCAAGGTGGAGATCAAACGAACGGTG CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG GCTGCACCATCTGTCTTCATCTTCCCGCCATCTG GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC ATGAGCAGTTGAAATCTGGAACTGCCTCTGTTG TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA TGTGCCTGCTGAATAACTTCTATCCCAGAGAGG CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG CCAAAGTACAGTGGAAGGTGGATAACGCCCTCC GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC AATCGGGTAACTCCCAGGAGAGTGTCACAGAGC GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC AGGACAGCAAGGACAGCACCTACAGCCTCAGC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC AGCACCCTGACGCTGAGCAAAGCAGACTACGAG CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC AAACACAAAGTCTACGCCTGCGAAGTCACCCAT GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTC CAGACCTACATCTGCAACGTGAATCACAAGCCC AACAGGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1955 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2112 AA EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM YQQKPGQAPRLLIYGAATRATGIPARFSGSGSGTE HWVRQAPGEGLEWVAAIWFDASDKYYADAVKG FTLTISSLQSEDFAVYYCQQYNNWPLTFGGGTKVE RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ IKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYP AIFGVVPDYWGQGTLVTVSSASTKGPSVFPLAPSS REAKVQWKVDNALQSGNSQESVTEQDSKDSTYSL KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG SSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV RGEC NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG SEQ ID NO: 385 GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 542 iPS:361178 2G10_LC1.004 NA GAAATAGTGATGACGCAGTCTCCAGCCACCCTG CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCAGCATCTGGATTCACCTTCAGTAACTATGGC GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC ATGCACTGGGTCCGCCAGGCTCCAGGCGAGGGG AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC CTGGAGTGGGTGGCAGCTATATGGTTTGATGCA ACTGGTATCCCAGCCAGGTTCAGTGGCAGTGGG AGTGATAAATACTATGCAGACTCCGTGAAGGGC TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC ACTGCAGTCTGAAGATTTTGCAGTTTATTACTGTC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC AGCAGTATAATAACTGGCCTCTCACTTTCGGCG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GAGGGACCAAGGTGGAGATCAAACGAACGGTG CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG GCTGCACCATCTGTCTTCATCTTCCCGCCATCTG GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC ATGAGCAGTTGAAATCTGGAACTGCCTCTGTTG TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA TGTGCCTGCTGAATAACTTCTATCCCAGAGAGG CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG CCAAAGTACAGTGGAAGGTGGATAACGCCCTCC GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC AATCGGGTAACTCCCAGGAGAGTGTCACAGAGC GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC AGGACAGCAAGGACAGCACCTACAGCCTCAGC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC AGCACCCTGACGCTGAGCAAAGCAGACTACGAG CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC AAACACAAAGTCTACGCCTGCGAAGTCACCCAT GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTC CAGACCTACATCTGCAACGTGAATCACAAGCCC AACAGGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1956 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2113 AA EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM YQQKPGQAPRLLIYGAATRATGIPARFSGSGSGTE HWVRQAPGEGLEWVAAIWFDASDKYYADSVKG FTLTISSLQSEDFAVYYCQQYNNWPLTFGGGTKVE RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ IKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYP AIFGVVPDYWGQGTLVTVSSASTKGPSVFPLAPSS REAKVQWKVDNALQSGNSQESVTEQDSKDSTYSL KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG SSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV RGEC NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG SEQ ID NO: 386 GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 543 iPS:361185 2G10_LC1.005 NA GAAATAGTGATGACGCAGTCTCCAGCCACCCTG CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCAGCATCTGGATTCACCTTCAGTAACTATGGC GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC ATGCACTGGGTCCGCCAGGCTCCAGGCGAGGGG AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC CTGGAGTGGGTGGCAGCTATATGGTTTGATGGA ACTGGTATCCCAGCCAGGTTCAGTGGCAGTGGG AGTGATAAATACTATGCAGACGCCGTGAAGGGC TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC CTGCAGTCTGAAGATTTTGCAGTTTATTACTGTC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC AGCAGTATAATAACTGGCCTCTCACTTTCGGCG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GAGGGACCAAGGTGGAGATCAAACGAACGGTG CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG GCTGCACCATCTGTCTTCATCTTCCCGCCATCTG GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC ATGAGCAGTTGAAATCTGGAACTGCCTCTGTTG TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA TGTGCCTGCTGAATAACTTCTATCCCAGAGAGG CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG CCAAAGTACAGTGGAAGGTGGATAACGCCCTCC GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC AATCGGGTAACTCCCAGGAGAGTGTCACAGAGC GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC AGGACAGCAAGGACAGCACCTACAGCCTCAGC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC AGCACCCTGACGCTGAGCAAAGCAGACTACGAG CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC AAACACAAAGTCTACGCCTGCGAAGTCACCCAT GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTC CAGACCTACATCTGCAACGTGAATCACAAGCCC AACAGGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1957 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2114 AA EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM YQQKPGQAPRLLIYGAATRATGIPARFSGSGSGTE HWVRQAPGEGLEWVAAIWFDGSDKYYADAVKG FTLTISSLQSEDFAVYYCQQYNNWPLTFGGGTKVE RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ IKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYP AIFGVVPDYWGQGTLVTVSSASTKGPSVFPLAPSS REAKVQWKVDNALQSGNSQESVTEQDSKDSTYSL KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG SSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV RGEC NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG SEQ ID NO: 387 GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 544 iPS:361192 2G10_LC1.006 NA GAAATAGTGATGACGCAGTCTCCAGCCACCCTG CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCAGCATCTGGATTCACCTTCAGTAACTATGGC GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC ATGCACTGGGTCCGCCAGGCTCCAGGCGAGGGG AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC CTGGAGTGGGTGGCAGCTATATGGTTTGATGCA ACTGGTATCCCAGCCAGGGTCAGTGGCAGTGGG AGTGATAAATACTATGCAGACGCCGTGAAGGGC TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC CTGCAGTCTGAAGATTTTGCAGTTTATTACTGTC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC AGCAGTATAATAACTGGCCTCTCACTTTCGGCG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GAGGGACCAAGGTGGAGATCAAACGAACGGTG CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG GCTGCACCATCTGTCTTCATCTTCCCGCCATCTG GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA AATGAGCAGTTGAAATCTGGAACTGCCTCTGTTG TGTGCCTGCTGAATAACTTCTATCCCAGAGAGG CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG CCAAAGTACAGTGGAAGGTGGATAACGCCCTCC GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC AATCGGGTAACTCCCAGGAGAGTGTCACAGAGC GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC AGGACAGCAAGGACAGCACCTACAGCCTCAGC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC AGCACCCTGACGCTGAGCAAAGCAGACTACGAG CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC AAACACAAAGTCTACGCCTGCGAAGTCACCCAT GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTC CAGACCTACATCTGCAACGTGAATCACAAGCCC AACAGGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1958 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2115 AA EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM YQQKPGQAPRLLIYGAATRATGIPARVSGSGSGTE HWVRQAPGEGLEWVAAIWFDASDKYYADAVKG FTLTISSLQSEDFAVYYCQQYNNWPLTFGGGTKVE RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ IKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYP AIFGVVPDYWGQGTLVTVSSASTKGPSVFPLAPSS REAKVQWKVDNALQSGNSQESVTEQDSKDSTYSL KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG SSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV RGEC NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG SEQ ID NO: 388 GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 545 iPS:359609 2G10_LC1.007 NA GAAATAGTGATGACGCAGTCTCCAGCCACCCTG CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCAGCATCTGGATTCACCTTCAGTAACTATGGC GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC CTGGAGTGGGTGGCAGCTATATGGTTTGATGCA ACTGGTATCCCAGCCAGGTTCAGTGGCAGTGGG AGTGATAAATACTATGCAGACGCCGTGAAGGGC TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC CTGGAGCCTGAAGATTTTGCAGTTTATTACTGTC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC AGCAGTATAATAACTTCCCTCTCACTTTCGGCGG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT AGGGACCAAGGTGGAGATCAAACGAACGGTGG CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG CTGCACCATCTGTCTTCATCTTCCCGCCATCTGA GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC TGAGCAGTTGAAATCTGGAACTGCCTCTGTTGT TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA GTGCCTGCTGAATAACTTCTATCCCAGAGAGGC CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG CAAAGTACAGTGGAAGGTGGATAACGCCCTCCA GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCA GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC GGACAGCAAGGACAGCACCTACAGCCTCAGCA CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC GCACCCTGACGCTGAGCAAAGCAGACTACGAGA CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC AACACAAAGTCTACGCCTGCGAAGTCACCCATC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC AGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCA CAGACCTACATCTGCAACGTGAATCACAAGCCC ACAGGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1959 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2116 AA EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM YQQKPGQAPRLLIYGAATRATGIPARFSGSGSGTE HWVRQAPGKGLEWVAAIWFDASDKYYADAVKG FTLTISSLEPEDFAVYYCQQYNNFPLTFGGGTKVEI RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR AIFGVVPDYWGQGTLVTVSSASTKGPSVFPLAPSS EAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV RGEC NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG SEQ ID NO: 389 GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 546 iPS:359615 2G10_LC1.008 NA GAAATAGTGATGACGCAGTCTCCAGCCACCCTG CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCAGCATCTGGATTCACCTTCAGTAACTATGGC GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC CTGGAGTGGGTGGCAGCTATATGGTTTGATGCA ACTGGTATCCCAGCCAGGTTCAGTGGCAGTGGG AGTGATAAATACTATGCAGACGCCGTGAAGGGC TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC CTGGAGCCTGAAGATTTTGCAGTTTATTACTGTC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC AGCAGTATAATAACTATCCTCTCACTTTCGGCGG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT AGGGACCAAGGTGGAGATCAAACGAACGGTGG CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG CTGCACCATCTGTCTTCATCTTCCCGCCATCTGA GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC TGAGCAGTTGAAATCTGGAACTGCCTCTGTTGT TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA GTGCCTGCTGAATAACTTCTATCCCAGAGAGGC CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG CAAAGTACAGTGGAAGGTGGATAACGCCCTCCA GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCA GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC AGGACAGCAAGGACAGCACCTACAGCCTCAGCA CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC GCACCCTGACGCTGAGCAAAGCAGACTACGAGA CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC AACACAAAGTCTACGCCTGCGAAGTCACCCATC GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC AGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCA CAGACCTACATCTGCAACGTGAATCACAAGCCC ACAGGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1960 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2117 AA EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM YQQKPGQAPRLLIYGAATRATGIPARFSGSGSGTE HWVRQAPGKGLEWVAAIWFDASDKYYADAVKG FTLTISSLEPEDFAVYYCQQYNNYPLTFGGGTKVEI RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR AIFGVVPDYWGQGTLVTVSSASTKGPSVFPLAPSS EAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV RGEC NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG SEQ ID NO: 390 GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 547 iPS:361196 2G10_LC1.009 NA GAAATAGTGATGACGCAGTCTCCAGCCACCCTG CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCAGCATCTGGATTCACCTTCAGTAACTATGGC GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC ATGCACTGGGTCCGCCAGGCTCCAGGCGAGGGG AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC CTGGAGTGGGTGGCAGCTATATGGTTTGATGCA ACTGGTATCCCAGCCAGGTTCAGTGGCAGTGGG AGTGATAAATACTATGCAGACGCCGTGAAGGGC TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC CTGGAGCCTGAAGATTTTGCAGTTTATTACTGTC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC AGCAGTATAATAACTGGCCTCTCACTTTCGGCG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GAGGGACCAAGGTGGAGATCAAACGAACGGTG CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG GCTGCACCATCTGTCTTCATCTTCCCGCCATCTG GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC ATGAGCAGTTGAAATCTGGAACTGCCTCTGTTG TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA TGTGCCTGCTGAATAACTTCTATCCCAGAGAGG CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG CCAAAGTACAGTGGAAGGTGGATAACGCCCTCC GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC AATCGGGTAACTCCCAGGAGAGTGTCACAGAGC GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC AGGACAGCAAGGACAGCACCTACAGCCTCAGC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC AGCACCCTGACGCTGAGCAAAGCAGACTACGAG CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC AAACACAAAGTCTACGCCTGCGAAGTCACCCAT GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTC CAGACCTACATCTGCAACGTGAATCACAAGCCC AACAGGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1961 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2118 AA EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM YQQKPGQAPRLLIYGAATRATGIPARFSGSGSGTE HWVRQAPGEGLEWVAAIWFDASDKYYADAVKG FTLTISSLEPEDFAVYYCQQYNNWPLTFGGGTKVE RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ IKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYP AIFGVVPDYWGQGTLVTVSSASTKGPSVFPLAPSS REAKVQWKVDNALQSGNSQESVTEQDSKDSTYSL KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG SSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV RGEC NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG SEQ ID NO: 391 GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 548 iPS:361202 2G10_LC1.010 NA GAAATAGTGATGACGCAGTCTCCAGCCACCCTG CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG TCTGTGTCTCCAGGGGAAAGAGCCACCCTCTCC GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT TGCAGGGCCAGTCAGAGTGTTAGCAGCAACTTA GCAGCATCTGGATTCACCTTCAGTAACTATGGC GCCTGGTACCAGCAGAAACCTGGCCAGGCTCCC ATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGGCTCCTCATCTATGGTGCAGCCACCAGGGCC CTGGAGTGGGTGGCAGCTATATGGTTTGATGCA ACTGGTATCCCAGCCAGGTTCAGTGGCAGTGGG AGTGATAAATACTATGCAGACGCCGTGAAGGGC TCTGGGACAGAGTTCACTCTCACCATCAGCAGC CGATTCACCATCTCCAGAGACAACTCCAAGAAC CTGGAGCCTGAAGATTTTGCAGTTTATTACTGTC ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC AGCAGTATAATAACTGGCCTCTCACTTTCGGCG GAGGACACGGCTGTGTATTACTGTGCGAGAGAT GAGGGACCAAGGTGGAGATCAAACGAACGGTG CAGGCGATTTTTGGAGTGGTCCCCGACTACTGG GCTGCACCATCTGTCTTCATCTTCCCGCCATCTG GGCCAGGGAACCCTGGTCACCGTCTCCTCAGCC ATGAGCAGTTGAAATCTGGAACTGCCTCTGTTG TCCACCAAGGGCCCATCGGTCTTCCCCCTGGCA TGTGCCTGCTGAATAACTTCTATCCCAGAGAGG CCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG CCAAAGTACAGTGGAAGGTGGATAACGCCCTCC GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC AATCGGGTAACTCCCAGGAGAGTGTCACAGAGC GAACCGGTGACGGTGTCGTGGAACTCAGGCGCC AGGACAGCAAGGACAGCACCTACAGCCTCAGC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTC AGCACCCTGACGCTGAGCAAAGCAGACTACGAG CTACAGTCCTCAGGACTCTACTCCCTCAGCAGC AAACACAAAGTCTACGCCTGCGAAGTCACCCAT GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTC CAGACCTACATCTGCAACGTGAATCACAAGCCC AAACAGGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 1962 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2119 AA EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGM YQQKPGQAPRLLIYGAATRATGIPARFSGSGSGTE HWVRQAPGKGLEWVAAIWFDASDKYYADAVKG FTLTISSLEPEDFAVYYCQQYNNWPLTFGGGTKVE RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQ IKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYP AIFGVVPDYWGQGTLVTVSSASTKGPSVFPLAPSS REAKVQWKVDNALQSGNSQESVTEQDSKDSTYSL KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG SSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV RGEC NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG SEQ ID NO: 392 GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 549 iPS:359644 18E3.002 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG CAGGTGCAGTTGCAGGAGTCGGGCCCAGGACTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GTGAAGCCTTCAGAGACCCTGTCCCTCACCTGC GCAGGGCCAGTCAGAGTATTAGTTACAGTTACT ACTGTCTCTGGTGACTCCATCAGCAGTGGTGGTT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC ACTACTGGAGCTGGATCCGCCAGCCCCCAGGGA CCCGGCTCCTCATCTATGGTGCATCCAGCAGGG AGGGCCTGGAGTGGATTGGGTACATCTATTACA CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GTGGGAGCACCTACTACAACCCGTCCCTCAAGA GGTCTGGGACAGACTTCACTCTCACCATCAGCA GTCGAGTTACCATATCAGTAGACACGTCTAAGA GACTGGAGCCTGATGATTTTGCAGTGTATTACTG ACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGC TCAGCAGTATGGTAGTTCACCGCTCACTTTCGGC CGCGGACACGGCCGTGTATTACTGTGCGAGAGA GGAGGGACCAAGGTGGAGATCAAACGAACGGT TCGTATTACGATTTTTGGAGTGGTTATGGGGGGC GGCTGCACCATCTGTCTTCATCTTCCCGCCATCT GGTATGGACGTCTGGGGCCAAGGGACCACGGTC GATGAGCAGTTGAAATCTGGAACTGCCTCTGTT ACCGTCTCCTCAGCCTCCACCAAGGGCCCATCG GTGTGCCTGCTGAATAACTTCTATCCCAGAGAG GTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCT GCCAAAGTACAGTGGAAGGTGGATAACGCCCTC CTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCA CAATCGGGTAACTCCCAGGAGAGTGTCACAGAG AGGACTACTTCCCCGAACCGGTGACGGTGTCGT CAGGACAGCAAGGACAGCACCTACAGCCTCAGC GGAACTCAGGCGCCCTGACCAGCGGCGTGCACA AGCACCCTGACGCTGAGCAAAGCAGACTACGAG CCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTA AAACACAAAGTCTACGCCTGCGAAGTCACCCAT CTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAG CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTC CAGCTTGGGCACCCAGACCTACATCTGCAACGT AACAGGGGAGAGTGT GAATCACAAGCCCAGCAACACCAAGGTGGACA SEQ ID NO: 1963 AGAAAGTTGAGCCCAAATCTTGTGACAAAACTC ACACATGCCCACCGTGCCCAGCACCTGAACTCC TGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAA ACCCAAGGACACCCTCATGATCTCCCGGACCCC TGAGGTCACATGCGTGGTGGTGGACGTGAGCCA CGAAGACCCTGAGGTCAAGTTCAACTGGTACGT GGACGGCGTGGAGGTGCATAATGCCAAGACAA AGCCGTGTGAGGAGCAGTACGGCAGCACGTACC GTTGTGTCAGCGTCCTCACCGTCCTGCACCAGG ACTGGCTGAATGGCAAGGAGTACAAGTGCAAG GTCTCCAACAAAGCCCTCCCAGCCCCCATCGAG AAAACCATCTCCAAAGCCAAAGGGCAGCCCCGA GAACCACAGGTGTACACCCTGCCCCCATCCCGG GAGGAGATGACCAAGAACCAGGTCAGCCTGAC CTGCCTGGTCAAAGGCTTCTATCCCAGCGACAT CGCCGTGGAGTGGGAGAGCAATGGGCAGCCGG AGAACAACTACAAGACCACGCCTCCCGTGCTGG ACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCT CACCGTGGACAAGAGCAGGTGGCAGCAGGGGA ACGTCTTCTCATGCTCCGTGATGCATGAGGCTCT GCACAACCACTACACGCAGAAGAGCCTCTCCCT GTCTCCGGGTAAA SEQ ID NO: 2120 AA EIVLTQSPGTLSLSPGERATLSCRASQSISYSYLAW QVQLQESGPGLVKPSETLSLTCTVSGDSISSGGYY YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF WSWIRQPPGKGLEWIGYIYYSGSTYYNPSLKSRVT TLTISRLEPDDFAVYYCQQYGSSPLTFGGGTKVEIK ISVDTSKNQFSLKLSSVTAADTAVYYCARDRITIFG RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE VVMGGGMDVWGQGTTVTVSSASTKGPSVFPLAP AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSS SSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS TLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN GEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 393 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 550 iPS:361206 18E3.003 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG CAGGTGCAGTTGCAGGAGTCGGGCCCAGGACTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GTGAAGCCTTCAGAGACCCTGTCCCTCACCTGC GCAGGGCCAGTCAGAGTATTAGTTACAGTTACT ACTGTCTCTGGTGACTCCATCAGCAGTGGTGGTT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC ACTACTGGAGCTGGATCCGCCAGCCCCCAGGGA CCCGGCTCCTCATCTATGGTGCATCCAGCAGGG AGGGCCTGGAGTGGATTGGGTACATCTATTACA CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GTGGGAGCACCTACTACAACCCGTCCCTCAAGA GGTCTGGGACAGACTTCACTCTCACCATCAGCA GTCGAGTTACCATATCAGTAGACACGTCTAAGA GACAGGAGCCTGATGATTTTGCAGTGTATTACT ACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGC GTCAGCAGTATGGTAGTTCACCGCTCACTTTCGG CGCGGACACGGCCGTGTATTACTGTGCGAGAGA CGGAGGGACCAAGGTGGAGATCAAACGAACGG TCGTATTACGATTTTTGGAGTGGTTATGGGGGGC TGGCTGCACCATCTGTCTTCATCTTCCCGCCATC GGTATGGACGTCTGGGGCCAAGGGACCACGGTC TGATGAGCAGTTGAAATCTGGAACTGCCTCTGT ACCGTCTCCTCAGCCTCCACCAAGGGCCCATCG TGTGTGCCTGCTGAATAACTTCTATCCCAGAGA GTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCT GGCCAAAGTACAGTGGAAGGTGGATAACGCCCT CTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCA CCAATCGGGTAACTCCCAGGAGAGTGTCACAGA AGGACTACTTCCCCGAACCGGTGACGGTGTCGT GCAGGACAGCAAGGACAGCACCTACAGCCTCA GGAACTCAGGCGCCCTGACCAGCGGCGTGCACA GCAGCACCCTGACGCTGAGCAAAGCAGACTACG CCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTA AGAAACACAAAGTCTACGCCTGCGAAGTCACCC CTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAG ATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCT CAGCTTGGGCACCCAGACCTACATCTGCAACGT TCAACAGGGGAGAGTGT GAATCACAAGCCCAGCAACACCAAGGTGGACA SEQ ID NO: 1964 AGAAAGTTGAGCCCAAATCTTGTGACAAAACTC ACACATGCCCACCGTGCCCAGCACCTGAACTCC ATGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAA ACCCAAGGACACCCTCATGATCTCCCGGACCCC TGAGGTCACATGCGTGGTGGTGGACGTGAGCCA CGAAGACCCTGAGGTCAAGTTCAACTGGTACGT GGACGGCGTGGAGGTGCATAATGCCAAGACAA AGCCGTGTGAGGAGCAGTACGGCAGCACGTACC GTTGTGTCAGCGTCCTCACCGTCCTGCACCAGG ACTGGCTGAATGGCAAGGAGTACAAGTGCAAG GTCTCCAACAAAGCCCTCCCAGCCCCCATCGAG AAAACCATCTCCAAAGCCAAAGGGCAGCCCCGA GAACCACAGGTGTACACCCTGCCCCCATCCCGG GAGGAGATGACCAAGAACCAGGTCAGCCTGAC CTGCCTGGTCAAAGGCTTCTATCCCAGCGACAT CGCCGTGGAGTGGGAGAGCAATGGGCAGCCGG AGAACAACTACAAGACCACGCCTCCCGTGCTGG ACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCT CACCGTGGACAAGAGCAGGTGGCAGCAGGGGA ACGTCTTCTCATGCTCCGTGATGCATGAGGCTCT GCACAACCACTACACGCAGAAGAGCCTCTCCCT GTCTCCGGGTAAA SEQ ID NO: 2121 AA EIVLTQSPGTLSLSPGERATLSCRASQSISYSYLAW QVQLQESGPGLVKPSETLSLTCTVSGDSISSGGYY YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF WSWIRQPPGKGLEWIGYIYYSGSTYYNPSLKSRVT TLTISRQEPDDFAVYYCQQYGSSPLTFGGGTKVEI ISVDTSKNQFSLKLSSVTAADTAVYYCARDRITIFG KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR VVMGGGMDVWGQGTTVTVSSASTKGPSVFPLAP EAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS SSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN RGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 394 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 551 iPS:359628 18E3.004 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG CAGGTGCAGTTGCAGGAGTCGGGCCCAGGACTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GTGAAGCCTTCACAGACCCTGTCCCTCACCTGC GCAGGGCCAGTCAGAGTATTAGTTACAGTTACT ACTGTCTCTGGTGACTCCATCAGCAGTGGTGGTT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC ACTACTGGAGCTGGATCCGCCAGCCCCCAGGGA CCCGGCTCCTCATCTATGGTGCATCCAGCAGGG AGGGCCTGGAGTGGATTGGGTACATCTATTACA CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GTGGGAGCACCTACTACAACCCGTCCCTCAAGA GGTCTGGGACAGACTTCACTCTCACCATCAGCA GTCGAGTTACCATATCAGTAGACACGTCTAAGA GACTGGAGCCTGATGATTTTGCAGTGTATTACTG ACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGC TCAGCAGTATGGTAGTTCACCGCTCACTTTCGGC CGCGGACACGGCCGTGTATTACTGTGCGAGAGA GGAGGGACCAAGGTGGAGATCAAACGAACGGT TCGTATTACGATTTTTGGAGTGGTTATGGGGGGC GGCTGCACCATCTGTCTTCATCTTCCCGCCATCT GGTATGGACGTCTGGGGCCAAGGGACCACGGTC GATGAGCAGTTGAAATCTGGAACTGCCTCTGTT ACCGTCTCCTCAGCCTCCACCAAGGGCCCATCG GTGTGCCTGCTGAATAACTTCTATCCCAGAGAG GTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCT GCCAAAGTACAGTGGAAGGTGGATAACGCCCTC CTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCA CAATCGGGTAACTCCCAGGAGAGTGTCACAGAG AGGACTACTTCCCCGAACCGGTGACGGTGTCGT CAGGACAGCAAGGACAGCACCTACAGCCTCAGC GGAACTCAGGCGCCCTGACCAGCGGCGTGCACA AGCACCCTGACGCTGAGCAAAGCAGACTACGAG CCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTA AAACACAAAGTCTACGCCTGCGAAGTCACCCAT CTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAG CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTC CAGCTTGGGCACCCAGACCTACATCTGCAACGT AACAGGGGAGAGTGT GAATCACAAGCCCAGCAACACCAAGGTGGACA SEQ ID NO: 1965 AGAAAGTTGAGCCCAAATCTTGTGACAAAACTC ACACATGCCCACCGTGCCCAGCACCTGAACTCC TGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAA ACCCAAGGACACCCTCATGATCTCCCGGACCCC TGAGGTCACATGCGTGGTGGTGGACGTGAGCCA CGAAGACCCTGAGGTCAAGTTCAACTGGTACGT GGACGGCGTGGAGGTGCATAATGCCAAGACAA AGCCGTGTGAGGAGCAGTACGGCAGCACGTACC GTTGTGTCAGCGTCCTCACCGTCCTGCACCAGG ACTGGCTGAATGGCAAGGAGTACAAGTGCAAG GTCTCCAACAAAGCCCTCCCAGCCCCCATCGAG AAAACCATCTCCAAAGCCAAAGGGCAGCCCCGA GAACCACAGGTGTACACCCTGCCCCCATCCCGG GAGGAGATGACCAAGAACCAGGTCAGCCTGAC CTGCCTGGTCAAAGGCTTCTATCCCAGCGACAT CGCCGTGGAGTGGGAGAGCAATGGGCAGCCGG AGAACAACTACAAGACCACGCCTCCCGTGCTGG ACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCT CACCGTGGACAAGAGCAGGTGGCAGCAGGGGA ACGTCTTCTCATGCTCCGTGATGCATGAGGCTCT GCACAACCACTACACGCAGAAGAGCCTCTCCCT GTCTCCGGGTAAA SEQ ID NO: 2122 AA EIVLTQSPGTLSLSPGERATLSCRASQSISYSYLAW QVQLQESGPGLVKPSQTLSLTCTVSGDSISSGGYY YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF WSWIRQPPGKGLEWIGYIYYSGSTYYNPSLKSRVT TLTISRLEPDDFAVYYCQQYGSSPLTFGGGTKVEIK ISVDTSKNQFSLKLSSVTAADTAVYYCARDRITIFG RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE VVMGGGMDVWGQGTTVTVSSASTKGPSVFPLAP AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSS SSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS TLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN GEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 395 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 552 iPS:359637 18E3.005 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG CAGGTGCAGTTGCAGGAGTCGGGCCCAGGACTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GTGAAGCCTTCAGAGACCCTGTCCCTCACCTGC GCAGGGCCAGTCAGAGTATTAGTTACAGTTACT ACTGTCTCTGGTGACTCCATCAGCAGTGGTGGTT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC ACTACTGGAGCTGGATCCGCCAGCACCCAGGGA CCCGGCTCCTCATCTATGGTGCATCCAGCAGGG AGGGCCTGGAGTGGATTGGGTACATCTATTACA CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GTGGGAGCACCTACTACAACCCGTCCCTCAAGA GGTCTGGGACAGACTTCACTCTCACCATCAGCA GTCGAGTTACCATATCAGTAGACACGTCTAAGA GACTGGAGCCTGATGATTTTGCAGTGTATTACTG ACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGC TCAGCAGTATGGTAGTTCACCGCTCACTTTCGGC CGCGGACACGGCCGTGTATTACTGTGCGAGAGA GGAGGGACCAAGGTGGAGATCAAACGAACGGT TCGTATTACGATTTTTGGAGTGGTTATGGGGGGC GGCTGCACCATCTGTCTTCATCTTCCCGCCATCT GGTATGGACGTCTGGGGCCAAGGGACCACGGTC GATGAGCAGTTGAAATCTGGAACTGCCTCTGTT ACCGTCTCCTCAGCCTCCACCAAGGGCCCATCG GTGTGCCTGCTGAATAACTTCTATCCCAGAGAG GTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCT GCCAAAGTACAGTGGAAGGTGGATAACGCCCTC CTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCA CAATCGGGTAACTCCCAGGAGAGTGTCACAGAG AGGACTACTTCCCCGAACCGGTGACGGTGTCGT CAGGACAGCAAGGACAGCACCTACAGCCTCAGC GGAACTCAGGCGCCCTGACCAGCGGCGTGCACA AGCACCCTGACGCTGAGCAAAGCAGACTACGAG CCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTA AAACACAAAGTCTACGCCTGCGAAGTCACCCAT CTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAG CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTC CAGCTTGGGCACCCAGACCTACATCTGCAACGT AACAGGGGAGAGTGT GAATCACAAGCCCAGCAACACCAAGGTGGACA SEQ ID NO: 1966 AGAAAGTTGAGCCCAAATCTTGTGACAAAACTC ACACATGCCCACCGTGCCCAGCACCTGAACTCC TGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAA ACCCAAGGACACCCTCATGATCTCCCGGACCCC ATGAGGTCACATGCGTGGTGGTGGACGTGAGCCA CGAAGACCCTGAGGTCAAGTTCAACTGGTACGT GGACGGCGTGGAGGTGCATAATGCCAAGACAA AGCCGTGTGAGGAGCAGTACGGCAGCACGTACC GTTGTGTCAGCGTCCTCACCGTCCTGCACCAGG ACTGGCTGAATGGCAAGGAGTACAAGTGCAAG GTCTCCAACAAAGCCCTCCCAGCCCCCATCGAG AAAACCATCTCCAAAGCCAAAGGGCAGCCCCGA GAACCACAGGTGTACACCCTGCCCCCATCCCGG GAGGAGATGACCAAGAACCAGGTCAGCCTGAC CTGCCTGGTCAAAGGCTTCTATCCCAGCGACAT CGCCGTGGAGTGGGAGAGCAATGGGCAGCCGG AGAACAACTACAAGACCACGCCTCCCGTGCTGG ACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCT CACCGTGGACAAGAGCAGGTGGCAGCAGGGGA ACGTCTTCTCATGCTCCGTGATGCATGAGGCTCT GAACCACAGGTGTACACCCTGCCCCCATCCCGG GAGGAGATGACCAAGAACCAGGTCAGCCTGAC CTGCCTGGTCAAAGGCTTCTATCCCAGCGACAT CGCCGTGGAGTGGGAGAGCAATGGGCAGCCGG AGAACAACTACAAGACCACGCCTCCCGTGCTGG ACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCT CACCGTGGACAAGAGCAGGTGGCAGCAGGGGA ACGTCTTCTCATGCTCCGTGATGCATGAGGCTCT GCACAACCACTACACGCAGAAGAGCCTCTCCCT GTCTCCGGGTAAA SEQ ID NO: 2123 AA EIVLTQSPGTLSLSPGERATLSCRASQSISYSYLAW QVQLQESGPGLVKPSETLSLTCTVSGDSISSGGYY YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF WSWIRQHPGKGLEWIGYIYYSGSTYYNPSLKSRVT TLTISRLEPDDFAVYYCQQYGSSPLTFGGGTKVEIK ISVDTSKNQFSLKLSSVTAADTAVYYCARDRITIFG RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE VVMGGGMDVWGQGTTVTVSSASTKGPSVFPLAP AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSS SSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS TLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN GEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 396 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 553 iPS:361210 18E3.006 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG CAGGTGCAGTTGCAGGAGTCGGGCCCAGGACTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GTGAAGCCTTCACAGACCCTGTCCCTCACCTGC GCAGGGCCAGTCAGAGTATTAGTTACAGTTACT ACTGTCTCTGGTGACTCCATCAGCAGTGGTGGTT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC ACTACTGGAGCTGGATCCGCCAGCACCCAGGGA CCCGGCTCCTCATCTATGGTGCATCCAGCAGGG AGGGCCTGGAGTGGATTGGGTACATCTATTACA CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GTGGGAGCACCTACTACAACCCGTCCCTCAAGA GGTCTGGGACAGACTTCACTCTCACCATCAGCA GTCGAGTTACCATATCAGTAGACACGTCTAAGA GACTGGAGCCTGATGATTTTGCAGTGTATTACTG ACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGC TCAGCAGTATGGTAGTTCACCGCTCACTTTCGGC CGCGGACACGGCCGTGTATTACTGTGCGAGAGA GGAGGGACCAAGGTGGAGATCAAACGAACGGT TCGTATTACGATTTTTGGAGTGGTTATGGGGGGC GGCTGCACCATCTGTCTTCATCTTCCCGCCATCT GGTATGGACGTCTGGGGCCAAGGGACCACGGTC GATGAGCAGTTGAAATCTGGAACTGCCTCTGTT ACCGTCTCCTCAGCCTCCACCAAGGGCCCATCG GTGTGCCTGCTGAATAACTTCTATCCCAGAGAG GTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCT GCCAAAGTACAGTGGAAGGTGGATAACGCCCTC CTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCA CAATCGGGTAACTCCCAGGAGAGTGTCACAGAG AGGACTACTTCCCCGAACCGGTGACGGTGTCGT CAGGACAGCAAGGACAGCACCTACAGCCTCAGC GGAACTCAGGCGCCCTGACCAGCGGCGTGCACA AGCACCCTGACGCTGAGCAAAGCAGACTACGAG CCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTA AAACACAAAGTCTACGCCTGCGAAGTCACCCAT CTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAG CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTC CAGCTTGGGCACCCAGACCTACATCTGCAACGT AACAGGGGAGAGTGT GAATCACAAGCCCAGCAACACCAAGGTGGACA SEQ ID NO: 1967 AGAAAGTTGAGCCCAAATCTTGTGACAAAACTC ACACATGCCCACCGTGCCCAGCACCTGAACTCC TGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAA ACCCAAGGACACCCTCATGATCTCCCGGACCCC TGAGGTCACATGCGTGGTGGTGGACGTGAGCCA CGAAGACCCTGAGGTCAAGTTCAACTGGTACGT GGACGGCGTGGAGGTGCATAATGCCAAGACAA AGCCGTGTGAGGAGCAGTACGGCAGCACGTACC GTTGTGTCAGCGTCCTCACCGTCCTGCACCAGG ACTGGCTGAATGGCAAGGAGTACAAGTGCAAG GTCTCCAACAAAGCCCTCCCAGCCCCCATCGAG AAAACCATCTCCAAAGCCAAAGGGCAGCCCCGA GAACCACAGGTGTACACCCTGCCCCCATCCCGG GAGGAGATGACCAAGAACCAGGTCAGCCTGAC CTGCCTGGTCAAAGGCTTCTATCCCAGCGACAT CGCCGTGGAGTGGGAGAGCAATGGGCAGCCGG AGAACAACTACAAGACCACGCCTCCCGTGCTGG ACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCT CACCGTGGACAAGAGCAGGTGGCAGCAGGGGA ACGTCTTCTCATGCTCCGTGATGCATGAGGCTCT GCACAACCACTACACGCAGAAGAGCCTCTCCCT GTCTCCGGGTAAA SEQ ID NO: 2124 AA EIVLTQSPGTLSLSPGERATLSCRASQSISYSYLAW QVQLQESGPGLVKPSQTLSLTCTVSGDSISSGGYY YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF WSWIRQHPGKGLEWIGYIYYSGSTYYNPSLKSRVT TLTISRLEPDDFAVYYCQQYGSSPLTFGGGTKVEIK ISVDTSKNQFSLKLSSVTAADTAVYYCARDRITIFG RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE VVMGGGMDVWGQGTTVTVSSASTKGPSVFPLAP AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSS SSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS TLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN GEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 397 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 554 iPS:361214 18E3.007 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG CAGGTGCAGTTGCAGGAGTCGGGCCCAGGACTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GTGAAGCCTTCAGAGACCCTGTCCCTCACCTGC GCAGGGCCAGTCAGAGTATTAGTTACAGTTACT ACTGTCTCTGGTGACTCCATCAGCAGTGGTGGTT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC ACTACTGGAGCTGGATCCGCCAGCACCCAGGGA CCCGGCTCCTCATCTATGGTGCATCCAGCAGGG AGGGCCTGGAGTGGATTGGGTACATCTATTACA CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GTGGGAGCACCTACTACAACCCGTCCCTCAAGA GGTCTGGGACAGACTTCACTCTCACCATCAGCA GTCGAGTTACCATATCAGTAGACACGTCTAAGA GACAGGAGCCTGATGATTTTGCAGTGTATTACT ACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGC GTCAGCAGTATGGTAGTTCACCGCTCACTTTCGG CGCGGACACGGCCGTGTATTACTGTGCGAGAGA CGGAGGGACCAAGGTGGAGATCAAACGAACGG TCGTATTACGATTTTTGGAGTGGTTATGGGGGGC TGGCTGCACCATCTGTCTTCATCTTCCCGCCATC GGTATGGACGTCTGGGGCCAAGGGACCACGGTC TGATGAGCAGTTGAAATCTGGAACTGCCTCTGT ACCGTCTCCTCAGCCTCCACCAAGGGCCCATCG TGTGTGCCTGCTGAATAACTTCTATCCCAGAGA GTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCT GGCCAAAGTACAGTGGAAGGTGGATAACGCCCT CTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCA CCAATCGGGTAACTCCCAGGAGAGTGTCACAGA AGGACTACTTCCCCGAACCGGTGACGGTGTCGT GCAGGACAGCAAGGACAGCACCTACAGCCTCA GGAACTCAGGCGCCCTGACCAGCGGCGTGCACA GCAGCACCCTGACGCTGAGCAAAGCAGACTACG CCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTA AGAAACACAAAGTCTACGCCTGCGAAGTCACCC CTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAG AATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCT CAGCTTGGGCACCCAGACCTACATCTGCAACGT TCAACAGGGGAGAGTGT GAATCACAAGCCCAGCAACACCAAGGTGGACA SEQ ID NO: 1968 AGAAAGTTGAGCCCAAATCTTGTGACAAAACTC ACACATGCCCACCGTGCCCAGCACCTGAACTCC TGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAA ACCCAAGGACACCCTCATGATCTCCCGGACCCC TGAGGTCACATGCGTGGTGGTGGACGTGAGCCA CGAAGACCCTGAGGTCAAGTTCAACTGGTACGT GGACGGCGTGGAGGTGCATAATGCCAAGACAA AGCCGTGTGAGGAGCAGTACGGCAGCACGTACC GTTGTGTCAGCGTCCTCACCGTCCTGCACCAGG ACTGGCTGAATGGCAAGGAGTACAAGTGCAAG GTCTCCAACAAAGCCCTCCCAGCCCCCATCGAG AAAACCATCTCCAAAGCCAAAGGGCAGCCCCGA GAACCACAGGTGTACACCCTGCCCCCATCCCGG GAGGAGATGACCAAGAACCAGGTCAGCCTGAC CTGCCTGGTCAAAGGCTTCTATCCCAGCGACAT CGCCGTGGAGTGGGAGAGCAATGGGCAGCCGG AGAACAACTACAAGACCACGCCTCCCGTGCTGG ACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCT CACCGTGGACAAGAGCAGGTGGCAGCAGGGGA ACGTCTTCTCATGCTCCGTGATGCATGAGGCTCT GCACAACCACTACACGCAGAAGAGCCTCTCCCT SEQ ID NO: 2125 AA EIVLTQSPGTLSLSPGERATLSCRASQSISYSYLAW QVQLQESGPGLVKPSETLSLTCTVSGDSISSGGYY YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF WSWIRQHPGKGLEWIGYIYYSGSTYYNPSLKSRVT TLTISRQEPDDFAVYYCQQYGSSPLTFGGGTKVEI ISVDTSKNQFSLKLSSVTAADTAVYYCARDRITIFG KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR VVMGGGMDVWGQGTTVTVSSASTKGPSVFPLAP EAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS SSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN RGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 398 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 555 iPS:361218 18E3.008 NA GAAATTGTGTTGACGCAGTCTCCAGGCACCCTG CAGGTGCAGTTGCAGGAGTCGGGCCCAGGACTG TCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCT GTGAAGCCTTCACAGACCCTGTCCCTCACCTGC GCAGGGCCAGTCAGAGTATTAGTTACAGTTACT ACTGTCTCTGGTGACTCCATCAGCAGTGGTGGTT TAGCCTGGTACCAGCAGAAACCTGGCCAGGCTC ACTACTGGAGCTGGATCCGCCAGCCCCCAGGGA CCCGGCTCCTCATCTATGGTGCATCCAGCAGGG AGGGCCTGGAGTGGATTGGGTACATCTATTACA CCACTGGCATCCCAGACAGGTTCAGTGGCAGTG GTGGGAGCACCTACTACAACCCGTCCCTCAAGA GGTCTGGGACAGACTTCACTCTCACCATCAGCA GTCGAGTTACCATATCAGTAGACACGTCTAAGA GACAGGAGCCTGATGATTTTGCAGTGTATTACT ACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGC GTCAGCAGTATGGTAGTTCACCGCTCACTTTCGG CGCGGACACGGCCGTGTATTACTGTGCGAGAGA CGGAGGGACCAAGGTGGAGATCAAACGAACGG TCGTATTACGATTTTTGGAGTGGTTATGGGGGGC TGGCTGCACCATCTGTCTTCATCTTCCCGCCATC GGTATGGACGTCTGGGGCCAAGGGACCACGGTC TGATGAGCAGTTGAAATCTGGAACTGCCTCTGT ACCGTCTCCTCAGCCTCCACCAAGGGCCCATCG TGTGTGCCTGCTGAATAACTTCTATCCCAGAGA GTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCT GGCCAAAGTACAGTGGAAGGTGGATAACGCCCT CTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCA CCAATCGGGTAACTCCCAGGAGAGTGTCACAGA AGGACTACTTCCCCGAACCGGTGACGGTGTCGT GCAGGACAGCAAGGACAGCACCTACAGCCTCA GGAACTCAGGCGCCCTGACCAGCGGCGTGCACA GCAGCACCCTGACGCTGAGCAAAGCAGACTACG CCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTA AGAAACACAAAGTCTACGCCTGCGAAGTCACCC CTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAG ATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCT CAGCTTGGGCACCCAGACCTACATCTGCAACGT TCAACAGGGGAGAGTGT GAATCACAAGCCCAGCAACACCAAGGTGGACA SEQ ID NO: 1969 AGAAAGTTGAGCCCAAATCTTGTGACAAAACTC ACACATGCCCACCGTGCCCAGCACCTGAACTCC TGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAA ACCCAAGGACACCCTCATGATCTCCCGGACCCC TGAGGTCACATGCGTGGTGGTGGACGTGAGCCA CGAAGACCCTGAGGTCAAGTTCAACTGGTACGT GGACGGCGTGGAGGTGCATAATGCCAAGACAA AGCCGTGTGAGGAGCAGTACGGCAGCACGTACC GTTGTGTCAGCGTCCTCACCGTCCTGCACCAGG ACTGGCTGAATGGCAAGGAGTACAAGTGCAAG GTCTCCAACAAAGCCCTCCCAGCCCCCATCGAG AAAACCATCTCCAAAGCCAAAGGGCAGCCCCGA SEQ ID NO: 2126 AA EIVLTQSPGTLSLSPGERATLSCRASQSISYSYLAW QVQLQESGPGLVKPSQTLSLTCTVSGDSISSGGYY YQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDF WSWIRQPPGKGLEWIGYIYYSGSTYYNPSLKSRVT TLTISRQEPDDFAVYYCQQYGSSPLTFGGGTKVEI ISVDTSKNQFSLKLSSVTAADTAVYYCARDRITIFG KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR VVMGGGMDVWGQGTTVTVSSASTKGPSVFPLAP EAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS SSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN RGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 399 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 556 iPS:361222 5C2.006 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT CTTGAGTGGATGGGGTGGATCAACCCTGAAAGT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA AGGGTCACCATGACCAGGGACACGTCCATCAGC CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG ACAGCCTACATGGAACTGAACAGGCTGAGATCT TGGCAGTTTTTTACTGTCAACAATATTATAGTAC GACGACACGGCCGTGTATTACTGTGCGAGAGAG TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AATCAAACGAACGGTGGCTGCACCATCTGTCTT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CATCTTCCCGCCATCTGATGAGCAGTTGAAATCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC GGAACTGCCTCTGTTGTGTGCCTGCTGAATAACT CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TCTATCCCAGAGAGGCCAAAGTACAGTGGAAGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA TGGATAACGCCCTCCAATCGGGTAACTCCCAGG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGAGTGTCACAGAGCAGGACAGCAAGGACAGC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC ACCTACAGCCTCAGCAGCACCCTGACGCTGAGC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AAAGCAGACTACGAGAAACACAAAGTCTACGC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCC GGCACCCAGACCTACATCTGCAACGTGAATCAC CGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1970 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC ATCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2127 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPESGGTDYSQRFQGR GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ VTMTRDTSISTAYMELNRLRSDDTAVYYCAREATI GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL FGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS NNFYPREAKVQWKVDNALQSGNSQESVTEQDSK SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS DSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSP GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VTKSFNRGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 400 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 557 iPS:361229 5C2.007 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT CTTGAGTGGATGGGGTGGATCAACCCTGAAAGT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA AGGTTCACCATGACCAGGGACACGTCCATCAGC CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG ACAGCCTACATGGAACTGAACAGGCTGAGATCT TGGCAGTTTTTTACTGTCAACAATATTATAGTAC GACGACACGGCCGTGTATTACTGTGCGAGAGAG TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AATCAAACGAACGGTGGCTGCACCATCTGTCTT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CATCTTCCCGCCATCTGATGAGCAGTTGAAATCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC GGAACTGCCTCTGTTGTGTGCCTGCTGAATAACT CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TCTATCCCAGAGAGGCCAAAGTACAGTGGAAGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA TGGATAACGCCCTCCAATCGGGTAACTCCCAGG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGAGTGTCACAGAGCAGGACAGCAAGGACAGC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC ACCTACAGCCTCAGCAGCACCCTGACGCTGAGC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AAAGCAGACTACGAGAAACACAAAGTCTACGC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCC GGCACCCAGACCTACATCTGCAACGTGAATCAC CGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1971 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2128 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPESGGTDYSQRFQGR GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ FTMTRDTSISTAYMELNRLRSDDTAVYYCAREATI GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL FGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS NNFYPREAKVQWKVDNALQSGNSQESVTEQDSK SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS DSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSP GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VTKSFNRGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 401 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 558 iPS:361236 5C2.008 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT CTTGAGTGGATGGGGTGGATCAACCCTGACGCT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA AGGGTCACCATGACCAGGGACACGTCCATCAGC CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG ACAGCCTACATGGAACTGAACAGGCTGAGATCT TGGCAGTTTTTTACTGTCAACAATATTATAGTAC GACGACACGGCCGTGTATTACTGTGCGAGAGAG TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AATCAAACGAACGGTGGCTGCACCATCTGTCTT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CATCTTCCCGCCATCTGATGAGCAGTTGAAATCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC GGAACTGCCTCTGTTGTGTGCCTGCTGAATAACT CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TCTATCCCAGAGAGGCCAAAGTACAGTGGAAGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA TGGATAACGCCCTCCAATCGGGTAACTCCCAGG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGAGTGTCACAGAGCAGGACAGCAAGGACAGC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC ACCTACAGCCTCAGCAGCACCCTGACGCTGAGC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AAAGCAGACTACGAGAAACACAAAGTCTACGC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCC GGCACCCAGACCTACATCTGCAACGTGAATCAC CGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1972 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT AGACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2129 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPDAGGTDYSQRFQG GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ RVTMTRDTSISTAYMELNRLRSDDTAVYYCAREA GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL TIFGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLA NNFYPREAKVQWKVDNALQSGNSQESVTEQDSK PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT DSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSP SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC VTKSFNRGEC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL SEQ ID NO: 402 LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK SEQ ID NO: 559 iPS:359685 5C2.009 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT CTTGAGTGGATGGGGTGGATCAACCCTGACGCT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA AGGTTCACCATGACCAGGGACACGTCCATCAGC CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG ACAGCCTACATGGAACTGAACAGGCTGAGATCT TGGCAGTTTTTTACTGTCAACAATATTATAGTAC GACGACACGGCCGTGTATTACTGTGCGAGAGAG TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AATCAAACGAACGGTGGCTGCACCATCTGTCTT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CATCTTCCCGCCATCTGATGAGCAGTTGAAATCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC GGAACTGCCTCTGTTGTGTGCCTGCTGAATAACT CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TCTATCCCAGAGAGGCCAAAGTACAGTGGAAGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA TGGATAACGCCCTCCAATCGGGTAACTCCCAGG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGAGTGTCACAGAGCAGGACAGCAAGGACAGC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC ACCTACAGCCTCAGCAGCACCCTGACGCTGAGC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AAAGCAGACTACGAGAAACACAAAGTCTACGC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCC GGCACCCAGACCTACATCTGCAACGTGAATCAC CGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1973 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2130 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPDAGGTDYSQRFQG GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ RFTMTRDTSISTAYMELNRLRSDDTAVYYCAREA GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL TIFGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLA NNFYPREAKVQWKVDNALQSGNSQESVTEQDSK PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT DSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSP SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC VTKSFNRGEC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL SEQ ID NO: 403 LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK SEQ ID NO: 560 iPS:361240 5C2.010 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT CTTGAGTGGATGGGGTGGATCAACCCTGACAGT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA AGGGTCACCATGACCAGGGACACGTCCATCAGC CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG ACAGCCTACATGGAACTGAACAGGCTGAGATCT TGGCAGTTTTTTACTGTCAACAATATTATAGTAC GACGACACGGCCGTGTATTACTGTGCGAGAGAG TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AATCAAACGAACGGTGGCTGCACCATCTGTCTT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CATCTTCCCGCCATCTGATGAGCAGTTGAAATCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC GGAACTGCCTCTGTTGTGTGCCTGCTGAATAACT CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TCTATCCCAGAGAGGCCAAAGTACAGTGGAAGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA TGGATAACGCCCTCCAATCGGGTAACTCCCAGG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGAGTGTCACAGAGCAGGACAGCAAGGACAGC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC ACCTACAGCCTCAGCAGCACCCTGACGCTGAGC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AAAGCAGACTACGAGAAACACAAAGTCTACGC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCC GGCACCCAGACCTACATCTGCAACGTGAATCAC CGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1974 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT ACAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2131 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPDSGGTDYSQRFQGR GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ VTMTRDTSISTAYMELNRLRSDDTAVYYCAREATI GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL FGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS NNFYPREAKVQWKVDNALQSGNSQESVTEQDSK SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS DSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSP GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VTKSFNRGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 404 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 561 iPS:361247 5C2.011 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT CTTGAGTGGATGGGGTGGATCAACCCTGACAGT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA AGGTTCACCATGACCAGGGACACGTCCATCAGC CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG ACAGCCTACATGGAACTGAACAGGCTGAGATCT TGGCAGTTTTTTACTGTCAACAATATTATAGTAC GACGACACGGCCGTGTATTACTGTGCGAGAGAG TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AATCAAACGAACGGTGGCTGCACCATCTGTCTT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CATCTTCCCGCCATCTGATGAGCAGTTGAAATCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC GGAACTGCCTCTGTTGTGTGCCTGCTGAATAACT CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TCTATCCCAGAGAGGCCAAAGTACAGTGGAAGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA TGGATAACGCCCTCCAATCGGGTAACTCCCAGG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGAGTGTCACAGAGCAGGACAGCAAGGACAGC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC ACCTACAGCCTCAGCAGCACCCTGACGCTGAGC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AAAGCAGACTACGAGAAACACAAAGTCTACGC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCC GGCACCCAGACCTACATCTGCAACGTGAATCAC CGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1975 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2132 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPDSGGTDYSQRFQGR GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ FTMTRDTSISTAYMELNRLRSDDTAVYYCAREATI GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL FGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS NNFYPREAKVQWKVDNALQSGNSQESVTEQDSK SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS DSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSP GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VTKSFNRGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 405 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 562 iPS:361254 5C2.012 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT CTTGAGTGGATGGGGTGGATCAACCCTGACAGT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA AGGGTCACCATGACCAGGGACACGTCCATCAGC CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG ACAGCCTACATGGAACTGAACAGGCTGAGATCT TGGCAGTTTTTTACTGTCAACAATATTATAGTAC GACGACACGGCCGTGTATTACTGTGCGAGAGAG TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AATCAAACGAACGGTGGCTGCACCATCTGTCTT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CATCTTCCCGCCATCTGATGAGCAGTTGAAATCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC GGAACTGCCTCTGTTGTGTGCCTGCTGAATAACT CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TCTATCCCAGAGAGGCCAAAGTACAGTGGAAGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA TGGATAACGCCCTCCAATCGGGTAACTCCCAGG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGAGTGTCACAGAGCAGGACAGCAAGGACAGC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC ACCTACAGCCTCAGCAGCACCCTGACGCTGAGC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AAAGCAGACTACGAGAAACACAAAGTCTACGC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCC GGCACCCAGACCTACATCTGCAACGTGAATCAC CGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1976 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT AACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2133 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPDSGGTDYSQRFQGR GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ VTMTRDTSISTAYMELNRLRSDDTAVYYCAREATI GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL FGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS NNFYPREAKVQWKVDNALQSGNSQESVTEQDSK SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS DSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSP GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VTKSFNRGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 406 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 563 iPS:361261 5C2.013 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT CTTGAGTGGATGGGGTGGATCAACCCTGACGCT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA AGGTTCACCATGACCAGGGACACGTCCATCAGC CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG ACAGCCTACATGGAACTGAACAGGCTGAGATCT TGGCAGTTTTTTACTGTCAACAATATTATAGTAC GACGACACGGCCGTGTATTACTGTGCGAGAGAG TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AATCAAACGAACGGTGGCTGCACCATCTGTCTT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CATCTTCCCGCCATCTGATGAGCAGTTGAAATCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC GGAACTGCCTCTGTTGTGTGCCTGCTGAATAACT CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TCTATCCCAGAGAGGCCAAAGTACAGTGGAAGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA TGGATAACGCCCTCCAATCGGGTAACTCCCAGG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGAGTGTCACAGAGCAGGACAGCAAGGACAGC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC ACCTACAGCCTCAGCAGCACCCTGACGCTGAGC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AAAGCAGACTACGAGAAACACAAAGTCTACGC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCC GGCACCCAGACCTACATCTGCAACGTGAATCAC CGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1977 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2134 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPDAGGTDYSQRFQG GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ RFTMTRDTSISTAYMELNRLRSDDTAVYYCAREA GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL TIFGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLA NNFYPREAKVQWKVDNALQSGNSQESVTEQDSK PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT DSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSP SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC VTKSFNRGEC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL SEQ ID NO: 407 LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK SEQ ID NO: 564 iPS:361268 5C2.014 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG CAACCAGGACATCCTCCTAAGCTGCTCATTTACT CTTGAGTGGATGGGGTGGATCAACCCTGACGCT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA AGGGTCACCATGACCAGGGACACGTCCATCAGC CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG ACAGCCTACATGGAACTGAACAGGCTGAGATCT TGGCAGTTTTTTACTGTCAACAATATTATAGTAC GACGACACGGCCGTGTATTACTGTGCGAGAGAG TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AATCAAACGAACGGTGGCTGCACCATCTGTCTT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CATCTTCCCGCCATCTGATGAGCAGTTGAAATCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC GGAACTGCCTCTGTTGTGTGCCTGCTGAATAACT CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TCTATCCCAGAGAGGCCAAAGTACAGTGGAAGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA TGGATAACGCCCTCCAATCGGGTAACTCCCAGG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGAGTGTCACAGAGCAGGACAGCAAGGACAGC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC ACCTACAGCCTCAGCAGCACCCTGACGCTGAGC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AAAGCAGACTACGAGAAACACAAAGTCTACGC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCC GGCACCCAGACCTACATCTGCAACGTGAATCAC CGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1978 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG AGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2135 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQQPGHPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPDAGGTDYSQRFQG GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ RVTMTRDTSISTAYMELNRLRSDDTAVYYCAREA GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL TIFGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLA NNFYPREAKVQWKVDNALQSGNSQESVTEQDSK PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT DSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSP SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC VTKSFNRGEC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL SEQ ID NO: 408 LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK SEQ ID NO: 565 iPS:359669 5C2.015 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG AAACCAGGACAACCTCCTAAGCTGCTCATTTAC CTTGAGTGGATGGGGTGGATCAACCCTGACGCT TGGGCATCTACCCGGGAATCCGGGGTCCCTGAC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAGCAGCCTGCAGGCTGAAGAT ACAGCCTACATGGAACTGAACAGCCTGAGATCT GTGGCAGTTTTTTACTGTCAACAATATTATAGTA GACGACACGGCCGTGTATTACTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AAATCAAACGAACGGTGGCTGCACCATCTGTCT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA GTGGATAACGCCCTCCAATCGGGTAACTCCCAG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC GAGAGTGTCACAGAGCAGGACAGCAAGGACAG AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC CACCTACAGCCTCAGCAGCACCCTGACGCTGAG GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC CAAAGCAGACTACGAGAAACACAAAGTCTACG AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC GGCACCCAGACCTACATCTGCAACGTGAATCAC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1979 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2136 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQKPGQPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPDAGGTDYSQRFQG GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ RVTMTRDTSISTAYMELNSLRSDDTAVYYCAREA GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL TIFGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLA NNFYPREAKVQWKVDNALQSGNSQESVTEQDSK PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT DSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSP SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC VTKSFNRGEC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL SEQ ID NO: 409 LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK SEQ ID NO: 566 iPS:359678 5C2.016 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGG AAACCAGGACAACCTCCTAAGCTGCTCATTTAC CTTGAGTGGATGGGGTGGATCAACCCTGAAAGT TGGGCATCTACCCGGGAATCCGGGGTCCCTGAC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAGCAGCCTGCAGGCTGAAGAT ACAGCCTACATGGAACTGAACAGCCTGAGATCT GTGGCAGTTTTTTACTGTCAACAATATTATAGTA GACGACACGGCCGTGTATTACTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AAATCAAACGAACGGTGGCTGCACCATCTGTCT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA GTGGATAACGCCCTCCAATCGGGTAACTCCCAG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC GAGAGTGTCACAGAGCAGGACAGCAAGGACAG AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC CACCTACAGCCTCAGCAGCACCCTGACGCTGAG GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC CAAAGCAGACTACGAGAAACACAAAGTCTACG AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC GGCACCCAGACCTACATCTGCAACGTGAATCAC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1980 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC AATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2137 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQKPGQPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPESGGTDYSQRFQGR GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ VTMTRDTSISTAYMELNSLRSDDTAVYYCAREATI GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL FGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS NNFYPREAKVQWKVDNALQSGNSQESVTEQDSK SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS DSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSP GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VTKSFNRGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 410 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 567 iPS:361275 11C1.002 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTACAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAACAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGTGTGGATGGGGTGGATCAGCCCTAACAGT TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC GGTGAAACAAGCTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTTCTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGAACGGTGGCTGCACCATCTGTCT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA GTGGATAACGCCCTCCAATCGGGTAACTCCCAG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC GAGAGTGTCACAGAGCAGGACAGCAAGGACAG AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC CACCTACAGCCTCAGCAGCACCCTGACGCTGAG GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC CAAAGCAGACTACGAGAAACACAAAGTCTACG AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC GGCACCCAGACCTACATCTGCAACGTGAATCAC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1981 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2138 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG HWVRQAPGQGLVWMGWISPNSGETSYAQKFQDR SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF VTMTRDTSISTAYMELSRLRSDDTAVYFCAREATI GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC FGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS LLNNFYPREAKVQWKVDNALQSGNSQESVTEQDS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS KDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN PVTKSFNRGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 411 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 568 iPS:361282 11C1.003 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTACAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAACAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGTGTGGATGGGGTGGATCAGCCCTAACAGT TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC GGTGACACAAGCTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTTCTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGAACGGTGGCTGCACCATCTGTCT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA GTGGATAACGCCCTCCAATCGGGTAACTCCCAG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC GAGAGTGTCACAGAGCAGGACAGCAAGGACAG AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC CACCTACAGCCTCAGCAGCACCCTGACGCTGAG GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC CAAAGCAGACTACGAGAAACACAAAGTCTACG AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC GGCACCCAGACCTACATCTGCAACGTGAATCAC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1982 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG ATAAA SEQ ID NO: 2139 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG HWVRQAPGQGLVWMGWISPNSGDTSYAQKFQDR SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF VTMTRDTSISTAYMELSRLRSDDTAVYFCAREATI GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC FGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS LLNNFYPREAKVQWKVDNALQSGNSQESVTEQDS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS KDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN PVTKSFNRGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 412 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 569 iPS:361289 11C1.004 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTACAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAACAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGTGTGGATGGGGTGGATCAGCCCTAACAGT TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC GGTGAAACAAGCTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTTCTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGAACGGTGGCTGCACCATCTGTCT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA GTGGATAACGCCCTCCAATCGGGTAACTCCCAG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC GAGAGTGTCACAGAGCAGGACAGCAAGGACAG AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC CACCTACAGCCTCAGCAGCACCCTGACGCTGAG GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC CAAAGCAGACTACGAGAAACACAAAGTCTACG AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC GGCACCCAGACCTACATCTGCAACGTGAATCAC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1983 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2140 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG HWVRQAPGQGLVWMGWISPNSGETSYAQKFQDR SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF VTMTRDTSISTAYMELSRLRSDDTAVYFCAREATI GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC FGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS LLNNFYPREAKVQWKVDNALQSGNSQESVTEQDS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS KDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN PVTKSFNRGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 413 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 570 iPS:359712 11C1.005 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTACAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAACAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGTGTGGATGGGGTGGATCAGCCCTAACAGT TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC GGTGAAACAAGCTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTTCTGTACGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGAACGGTGGCTGCACCATCTGTCT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA GTGGATAACGCCCTCCAATCGGGTAACTCCCAG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC GAGAGTGTCACAGAGCAGGACAGCAAGGACAG AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC CACCTACAGCCTCAGCAGCACCCTGACGCTGAG GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC CAAAGCAGACTACGAGAAACACAAAGTCTACG AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC GGCACCCAGACCTACATCTGCAACGTGAATCAC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1984 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2141 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK VPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG HWVRQAPGQGLVWMGWISPNSGETSYAQKFQDR SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF VTMTRDTSISTAYMELSRLRSDDTAVYFCTREATI GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC FGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS LLNNFYPREAKVQWKVDNALQSGNSQESVTEQDS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS KDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN PVTKSFNRGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 414 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 571 iPS:361293 11C1.006 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTACAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAACAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGTGTGGATGGGGTGGATCAGCCCTAACAGT TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC GGTGACACAAGCTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTTCTGTACGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGAACGGTGGCTGCACCATCTGTCT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA GTGGATAACGCCCTCCAATCGGGTAACTCCCAG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC GAGAGTGTCACAGAGCAGGACAGCAAGGACAG AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC CACCTACAGCCTCAGCAGCACCCTGACGCTGAG GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC CAAAGCAGACTACGAGAAACACAAAGTCTACG AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC GGCACCCAGACCTACATCTGCAACGTGAATCAC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1985 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2142 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG HWVRQAPGQGLVWMGWISPNSGDTSYAQKFQDR SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF VTMTRDTSISTAYMELSRLRSDDTAVYFCTREATI GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC FGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS LLNNFYPREAKVQWKVDNALQSGNSQESVTEQDS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS KDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN PVTKSFNRGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 415 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 572 iPS:361297 11C1.007 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTACAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAACAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGTGTGGATGGGGTGGATCAGCCCTAACAGT TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC GGTGAAACAAGCTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTTCTGTACGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGAACGGTGGCTGCACCATCTGTCT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA GTGGATAACGCCCTCCAATCGGGTAACTCCCAG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC GAGAGTGTCACAGAGCAGGACAGCAAGGACAG AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC CACCTACAGCCTCAGCAGCACCCTGACGCTGAG GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC CAAAGCAGACTACGAGAAACACAAAGTCTACG AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC GGCACCCAGACCTACATCTGCAACGTGAATCAC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1986 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2143 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG HWVRQAPGQGLVWMGWISPNSGETSYAQKFQDR ASGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF VTMTRDTSISTAYMELSRLRSDDTAVYFCTREATI GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC FGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS LLNNFYPREAKVQWKVDNALQSGNSQESVTEQDS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS KDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN PVTKSFNRGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 416 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 573 iPS:361301 11C1.008 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTACAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAACAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGTGTGGATGGGGTGGATCAGCCCTAACAGT TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC GGTGACACAAGCTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTTCTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGAACGGTGGCTGCACCATCTGTCT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA GTGGATAACGCCCTCCAATCGGGTAACTCCCAG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC GAGAGTGTCACAGAGCAGGACAGCAAGGACAG AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC CACCTACAGCCTCAGCAGCACCCTGACGCTGAG GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC CAAAGCAGACTACGAGAAACACAAAGTCTACG AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC GGCACCCAGACCTACATCTGCAACGTGAATCAC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1987 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2144 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG HWVRQAPGQGLVWMGWISPNSGDTSYAQKFQDR SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF VTMTRDTSISTAYMELSRLRSDDTAVYFCAREATI GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC FGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS LLNNFYPREAKVQWKVDNALQSGNSQESVTEQDS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS KDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN PVTKSFNRGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 417 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 574 iPS:359703 11C1.009 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCAGCTGGTACAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAACAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAAACTGCTCATTTAC CTTGAGTGGATGGGGTGGATCAGCCCTAACAGT TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC GGTGAAACAAGCTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGCCTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTTCTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGAACGGTGGCTGCACCATCTGTCT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA GTGGATAACGCCCTCCAATCGGGTAACTCCCAG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC GAGAGTGTCACAGAGCAGGACAGCAAGGACAG AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC CACCTACAGCCTCAGCAGCACCCTGACGCTGAG GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC CAAAGCAGACTACGAGAAACACAAAGTCTACG AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC GGCACCCAGACCTACATCTGCAACGTGAATCAC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1988 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2145 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPKLLIYWTSTRESGVPDRFSG HWVRQAPGQGLEWMGWISPNSGETSYAQKFQDR SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF VTMTRDTSISTAYMELSSLRSDDTAVYFCAREATI GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC FGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS ALLNNFYPREAKVQWKVDNALQSGNSQESVTEQDS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS KDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN PVTKSFNRGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 418 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 575 iPS:361305 11C1.010 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCAGCTGGTACAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAACAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGAGTGGATGGGGTGGATCAGCCCTAACAGT TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC GGTGAAACAAGCTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGACTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTTCTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGAACGGTGGCTGCACCATCTGTCT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA GTGGATAACGCCCTCCAATCGGGTAACTCCCAG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC GAGAGTGTCACAGAGCAGGACAGCAAGGACAG AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC CACCTACAGCCTCAGCAGCACCCTGACGCTGAG GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC CAAAGCAGACTACGAGAAACACAAAGTCTACG AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC GGCACCCAGACCTACATCTGCAACGTGAATCAC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1989 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2146 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG HWVRQAPGQGLEWMGWISPNSGETSYAQKFQDR SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF VTMTRDTSISTAYMELSRLRSDDTAVYFCAREATI GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC FGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS LLNNFYPREAKVQWKVDNALQSGNSQESVTEQDS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS KDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSS GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN PVTKSFNRGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 419 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 576 iPS:361312 13H12.002 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGA AAACCAGGACATCCTCCTAAGCTGCTCATTTACT CTTGAGTGGATGGGGTGGATCAACCCTGAAAGT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA AGGGTCACCATGACCAGGGACACGTCCATCAGC CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG ACAGCCTACATGGAACTGAGCAGGCTGAGATCT TGGCAGTTTTTTACTGTCAACAATATTATAGTAC GACGACACGGCCGTGTATTACTGTGCGAGAGAG TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AATCAAACGAACGGTGGCTGCACCATCTGTCTT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CATCTTCCCGCCATCTGATGAGCAGTTGAAATCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC GGAACTGCCTCTGTTGTGTGCCTGCTGAATAACT CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TCTATCCCAGAGAGGCCAAAGTACAGTGGAAGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA TGGATAACGCCCTCCAATCGGGTAACTCCCAGG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGAGTGTCACAGAGCAGGACAGCAAGGACAGC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC ACCTACAGCCTCAGCAGCACCCTGACGCTGAGC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AAAGCAGACTACGAGAAACACAAAGTCTACGC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCC GGCACCCAGACCTACATCTGCAACGTGAATCAC CGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1990 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2147 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQKPGHPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPESGGTDYSQRFQGR GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ VTMTRDTSISTAYMELSRLRSDDTAVYYCAREATI GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL FGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS NNFYPREAKVQWKVDNALQSGNSQESVTEQDSK SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS DSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSP GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN AVTKSFNRGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 420 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 577 iPS:359744 13H12.003 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGA AAACCAGGACATCCTCCTAAGCTGCTCATTTACT CTTGAGTGGATGGGGTGGATCAACCCTGAAAGT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA AGGTTCACCATGACCAGGGACACGTCCATCAGC CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG ACAGCCTACATGGAACTGAGCAGGCTGAGATCT TGGCAGTTTTTTACTGTCAACAATATTATAGTAC GACGACACGGCCGTGTATTACTGTGCGAGAGAG TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AATCAAACGAACGGTGGCTGCACCATCTGTCTT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CATCTTCCCGCCATCTGATGAGCAGTTGAAATCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC GGAACTGCCTCTGTTGTGTGCCTGCTGAATAACT CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TCTATCCCAGAGAGGCCAAAGTACAGTGGAAGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA TGGATAACGCCCTCCAATCGGGTAACTCCCAGG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGAGTGTCACAGAGCAGGACAGCAAGGACAGC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC ACCTACAGCCTCAGCAGCACCCTGACGCTGAGC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AAAGCAGACTACGAGAAACACAAAGTCTACGC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCC GGCACCCAGACCTACATCTGCAACGTGAATCAC CGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1991 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2148 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQKPGHPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPESGGTDYSQRFQGR GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ FTMTRDTSISTAYMELSRLRSDDTAVYYCAREATI GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL FGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS NNFYPREAKVQWKVDNALQSGNSQESVTEQDSK SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS DSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSP GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VTKSFNRGECVNHKP SNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 421 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 578 iPS:361319 13H12.004 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGA AAACCAGGACATCCTCCTAAGCTGCTCATTTACT CTTGAGTGGATGGGGTGGATCAACCCTGACAGT GGGCATCTACCCGGGAATCCGGGGTCCCTGACC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC GATTCAGTGGCAGCGGGTCTGGGACAGATTTCA AGGGTCACCATGACCAGGGACACGTCCATCAGC CTCTCACCATCAGCAGCCTGCAGGCTGAAGATG ACAGCCTACATGGAACTGAGCAGGCTGAGATCT TGGCAGTTTTTTACTGTCAACAATATTATAGTAC GACGACACGGCCGTGTATTACTGTGCGAGAGAG TCCGTGGACGTTCGGCCAAGGGACCAAGGTGGA GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AATCAAACGAACGGTGGCTGCACCATCTGTCTT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT CATCTTCCCGCCATCTGATGAGCAGTTGAAATCT CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC GGAACTGCCTCTGTTGTGTGCCTGCTGAATAACT CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TCTATCCCAGAGAGGCCAAAGTACAGTGGAAGG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA TGGATAACGCCCTCCAATCGGGTAACTCCCAGG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC AGAGTGTCACAGAGCAGGACAGCAAGGACAGC AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC ACCTACAGCCTCAGCAGCACCCTGACGCTGAGC GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC AAAGCAGACTACGAGAAACACAAAGTCTACGC AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCC GGCACCCAGACCTACATCTGCAACGTGAATCAC CGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1992 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2149 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQKPGHPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPDSGGTDYSQRFQGR GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ VTMTRDTSISTAYMELSRLRSDDTAVYYCAREATI GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL FGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS NNFYPREAKVQWKVDNALQSGNSQESVTEQDSK SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS DSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSP GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VTKSFNRGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 422 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED APEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 579 iPS:359737 13H12.005 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGA AAACCAGGACAACCTCCTAAGCTGCTCATTTAC CTTGAGTGGATGGGGTGGATCAACCCTGAAAGT TGGGCATCTACCCGGGAATCCGGGGTCCCTGAC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAGCAGCCTGCAGGCTGAAGAT ACAGCCTACATGGAACTGAGCAGCCTGAGATCT GTGGCAGTTTTTTACTGTCAACAATATTATAGTA GACGACACGGCCGTGTATTACTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AAATCAAACGAACGGTGGCTGCACCATCTGTCT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA GTGGATAACGCCCTCCAATCGGGTAACTCCCAG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC GAGAGTGTCACAGAGCAGGACAGCAAGGACAG AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC CACCTACAGCCTCAGCAGCACCCTGACGCTGAG GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC CAAAGCAGACTACGAGAAACACAAAGTCTACG AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC GGCACCCAGACCTACATCTGCAACGTGAATCAC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1993 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2150 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQKPGQPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPESGGTDYSQRFQGR GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ VTMTRDTSISTAYMELSSLRSDDTAVYYCAREATI GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL FGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS NNFYPREAKVQWKVDNALQSGNSQESVTEQDSK SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS DSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSP GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VTKSFNRGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 423 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 580 iPS:361326 13H12.006 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACATAGCTTGGTACCAGCAG ATCCACTGGGTGCGACAGGCCCCTGGACAAGGA AAACCAGGACAACCTCCTAAGCTGCTCATTTAC CTTGAGTGGATGGGGTGGATCAACCCTGAAAGT TGGGCATCTACCCGGGAATCCGGGGTCCCTGAC GGTGGCACAGACTATTCACAGAGGTTTCAGGGC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAGCAGCCTGCAGGCTGAAGAT ACAGCCTACATGGAACTGAGCAGGCTGAGATCT GTGGCAGTTTTTTACTGTCAACAATATTATAGTA GACGACACGGCCGTGTATTACTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGGTTATTGTACCGTTTG AAATCAAACGAACGGTGGCTGCACCATCTGTCT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA GTGGATAACGCCCTCCAATCGGGTAACTCCCAG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC GAGAGTGTCACAGAGCAGGACAGCAAGGACAG AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC CACCTACAGCCTCAGCAGCACCCTGACGCTGAG GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC CAAAGCAGACTACGAGAAACACAAAGTCTACG AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC GGCACCCAGACCTACATCTGCAACGTGAATCAC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1994 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2151 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYIAWYQQKPGQPPKLLIYWASTRESGVPDRFSGS HWVRQAPGQGLEWMGWINPESGGTDYSQRFQGR GSGTDFTLTISSLQAEDVAVFYCQQYYSTPWTFGQ VTMTRDTSISTAYMELSRLRSDDTAVYYCAREATI GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLL FGMVIVPFDYWGQGTLVTVSSASTKGPSVFPLAPS NNFYPREAKVQWKVDNALQSGNSQESVTEQDSK SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS DSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSP GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN VTKSFNRGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 424 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 581 iPS:361330 12H11.002 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAGCAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGAGTGGATGGGGTGGATAAGCCCTAACCAA TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC GGTGAAACAAACTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTACTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGAACGGTGGCTGCACCATCTGTCT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA GTGGATAACGCCCTCCAATCGGGTAACTCCCAG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC GAGAGTGTCACAGAGCAGGACAGCAAGGACAG AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC CACCTACAGCCTCAGCAGCACCCTGACGCTGAG GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC CAAAGCAGACTACGAGAAACACAAAGTCTACG AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC GGCACCCAGACCTACATCTGCAACGTGAATCAC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1995 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2152 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG HWVRQAPGQGLEWMGWISPNQGETNYAQKFQD SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF RVTMTRDTSISTAYMELSRLRSDDTAVYYCAREA GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC TIFGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLA LLNNFYPREAKVQWKVDNALQSGNSQESVTEQDS PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT KDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSS SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC PVTKSFNRGEC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL SEQ ID NO: 425 LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK SEQ ID NO: 582 iPS:361337 12H11.003 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAGCAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGAGTGGATGGGGTGGATAAGCCCTAACCAA TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC GGTGACACAAACTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTACTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGAACGGTGGCTGCACCATCTGTCT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA GTGGATAACGCCCTCCAATCGGGTAACTCCCAG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC GAGAGTGTCACAGAGCAGGACAGCAAGGACAG AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC CACCTACAGCCTCAGCAGCACCCTGACGCTGAG GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC CAAAGCAGACTACGAGAAACACAAAGTCTACG AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC GGCACCCAGACCTACATCTGCAACGTGAATCAC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1996 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2153 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG HWVRQAPGQGLEWMGWISPNQGDTNYAQKFQD SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF RVTMTRDTSISTAYMELSRLRSDDTAVYYCAREA GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC TIFGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLA LLNNFYPREAKVQWKVDNALQSGNSQESVTEQDS PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT KDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSS SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC PVTKSFNRGEC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL SEQ ID NO: 426 LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL AYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK SEQ ID NO: 583 iPS:361344 12H11.004 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAGCAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGAGTGGATGGGGTGGATAAGCCCTAACCAA TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC GGTGAAACAAACTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTACTGTACGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGAACGGTGGCTGCACCATCTGTCT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA GTGGATAACGCCCTCCAATCGGGTAACTCCCAG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC GAGAGTGTCACAGAGCAGGACAGCAAGGACAG AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC CACCTACAGCCTCAGCAGCACCCTGACGCTGAG GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC CAAAGCAGACTACGAGAAACACAAAGTCTACG AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC GGCACCCAGACCTACATCTGCAACGTGAATCAC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1997 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2154 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG HWVRQAPGQGLEWMGWISPNQGETNYAQKFQD SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF RVTMTRDTSISTAYMELSRLRSDDTAVYYCTREA GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC TIFGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLA LLNNFYPREAKVQWKVDNALQSGNSQESVTEQDS PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT KDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSS SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC PVTKSFNRGEC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL SEQ ID NO: 427 LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK SEQ ID NO: 584 iPS:361351 12H11.005 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAGCAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGAGTGGATGGGGTGGATAAGCCCTAACAAT TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC GGTGAAACAAACTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTACTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGAACGGTGGCTGCACCATCTGTCT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA GTGGATAACGCCCTCCAATCGGGTAACTCCCAG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC GAGAGTGTCACAGAGCAGGACAGCAAGGACAG AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC CACCTACAGCCTCAGCAGCACCCTGACGCTGAG GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC CAAAGCAGACTACGAGAAACACAAAGTCTACG AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC GGCACCCAGACCTACATCTGCAACGTGAATCAC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1998 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2155 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG HWVRQAPGQGLEWMGWISPNNGETNYAQKFQD SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF RVTMTRDTSISTAYMELSRLRSDDTAVYYCAREA GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC TIFGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLA LLNNFYPREAKVQWKVDNALQSGNSQESVTEQDS PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT KDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSS SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC PVTKSFNRGEC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL SEQ ID NO: 428 LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK SEQ ID NO: 585 iPS:361358 12H11.006 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAGCAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGAGTGGATGGGGTGGATAAGCCCTAACAAT TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC GGTGACACAAACTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTACTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGAACGGTGGCTGCACCATCTGTCT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA GTGGATAACGCCCTCCAATCGGGTAACTCCCAG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC GAGAGTGTCACAGAGCAGGACAGCAAGGACAG AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC CACCTACAGCCTCAGCAGCACCCTGACGCTGAG GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC CAAAGCAGACTACGAGAAACACAAAGTCTACG AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC GGCACCCAGACCTACATCTGCAACGTGAATCAC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 1999 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2156 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG HWVRQAPGQGLEWMGWISPNNGDTNYAQKFQD SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF RVTMTRDTSISTAYMELSRLRSDDTAVYYCAREA GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC TIFGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLA LLNNFYPREAKVQWKVDNALQSGNSQESVTEQDS PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT KDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSS SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC PVTKSFNRGEC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL SEQ ID NO: 429 LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK SEQ ID NO: 586 iPS:361365 12H11.007 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAGCAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGAGTGGATGGGGTGGATAAGCCCTAACCAA TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC GGTGACACAAACTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTACTGTACGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGAACGGTGGCTGCACCATCTGTCT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA GTGGATAACGCCCTCCAATCGGGTAACTCCCAG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC GAGAGTGTCACAGAGCAGGACAGCAAGGACAG AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC CACCTACAGCCTCAGCAGCACCCTGACGCTGAG GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC CAAAGCAGACTACGAGAAACACAAAGTCTACG AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC GGCACCCAGACCTACATCTGCAACGTGAATCAC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 2000 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2157 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG HWVRQAPGQGLEWMGWISPNQGDTNYAQKFQD SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF RVTMTRDTSISTAYMELSRLRSDDTAVYYCTREA GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC TIFGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLA LLNNFYPREAKVQWKVDNALQSGNSQESVTEQDS PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT KDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSS SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC PVTKSFNRGEC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL SEQ ID NO: 430 LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK SEQ ID NO: 587 iPS:361372 12H11.008 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG ATCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAGCAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGAGTGGATGGGGTGGATAAGCCCTAACAAT TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC GGTGAAACAAACTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTACTGTACGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGAACGGTGGCTGCACCATCTGTCT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA GTGGATAACGCCCTCCAATCGGGTAACTCCCAG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC GAGAGTGTCACAGAGCAGGACAGCAAGGACAG AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC CACCTACAGCCTCAGCAGCACCCTGACGCTGAG GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC CAAAGCAGACTACGAGAAACACAAAGTCTACG AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC GGCACCCAGACCTACATCTGCAACGTGAATCAC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 2001 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2158 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRDSGVPDRFSG HWVRQAPGQGLEWMGWISPNNGETNYAQKFQD SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF RVTMTRDTSISTAYMELSRLRSDDTAVYYCTREA GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC TIFGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLA LLNNFYPREAKVQWKVDNALQSGNSQESVTEQDS PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT KDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSS SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC PVTKSFNRGEC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL SEQ ID NO: 431 LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK SEQ ID NO: 588 iPS:361379 12H11.009 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAGCAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGAGTGGATGGGGTGGATAAGCCCTAACCAA TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC GGTGAAACAAACTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTACTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGAACGGTGGCTGCACCATCTGTCT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA GTGGATAACGCCCTCCAATCGGGTAACTCCCAG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC GAGAGTGTCACAGAGCAGGACAGCAAGGACAG AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC CACCTACAGCCTCAGCAGCACCCTGACGCTGAG GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC CAAAGCAGACTACGAGAAACACAAAGTCTACG AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC GGCACCCAGACCTACATCTGCAACGTGAATCAC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 2002 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2159 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG HWVRQAPGQGLEWMGWISPNQGETNYAQKFQD SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF RVTMTRDTSISTAYMELSRLRSDDTAVYYCAREA GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC TIFGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLA LLNNFYPREAKVQWKVDNALQSGNSQESVTEQDS PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT KDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSS SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC PVTKSFNRGECNVNHKP NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL SEQ ID NO: 432 LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK SEQ ID NO: 589 iPS:361383 12H11.010 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC ATGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAGCAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGAGTGGATGGGGTGGATAAGCCCTAACAAT TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC GGTGACACAAACTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTACTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGAACGGTGGCTGCACCATCTGTCT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA GTGGATAACGCCCTCCAATCGGGTAACTCCCAG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC GAGAGTGTCACAGAGCAGGACAGCAAGGACAG AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC CACCTACAGCCTCAGCAGCACCCTGACGCTGAG GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC CAAAGCAGACTACGAGAAACACAAAGTCTACG AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC GGCACCCAGACCTACATCTGCAACGTGAATCAC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 2003 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2160 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG HWVRQAPGQGLEWMGWISPNNGDTNYAQKFQD SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF RVTMTRDTSISTAYMELSRLRSDDTAVYYCAREA GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC TIFGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLA LLNNFYPREAKVQWKVDNALQSGNSQESVTEQDS PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT KDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSS SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC PVTKSFNRGEC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL SEQ ID NO: 433 LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK SEQ ID NO: 590 iPS:361387 12H11.011 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAGCAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGAGTGGATGGGGTGGATAAGCCCTAACCAA TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC GGTGACACAAACTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTACTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGAACGGTGGCTGCACCATCTGTCT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA GTGGATAACGCCCTCCAATCGGGTAACTCCCAG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC GAGAGTGTCACAGAGCAGGACAGCAAGGACAG AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC CACCTACAGCCTCAGCAGCACCCTGACGCTGAG GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC CAAAGCAGACTACGAGAAACACAAAGTCTACG AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC GGCACCCAGACCTACATCTGCAACGTGAATCAC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 2004 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2161 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG HWVRQAPGQGLEWMGWISPNQGDTNYAQKFQD SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF RVTMTRDTSISTAYMELSRLRSDDTAVYYCAREA GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC TIFGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLA LLNNFYPREAKVQWKVDNALQSGNSQESVTEQDS PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT KDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSS SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC PVTKSFNRGEC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL SEQ ID NO: 434 LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK SEQ ID NO: 591 iPS:361391 12H11.012 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCCGCTGGTGCAGTCTGGGGCTGAGGTG TCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAGCAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAAACCAGGACAGCCTCCTAACCTGCTCATTTAC CTTGAGTGGATGGGGTGGATAAGCCCTAACAAT TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC GGTGAAACAAACTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGGCTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTACTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGAACGGTGGCTGCACCATCTGTCT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA GTGGATAACGCCCTCCAATCGGGTAACTCCCAG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC GAGAGTGTCACAGAGCAGGACAGCAAGGACAG AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC CACCTACAGCCTCAGCAGCACCCTGACGCTGAG GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC CAAAGCAGACTACGAGAAACACAAAGTCTACG AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC GGCACCCAGACCTACATCTGCAACGTGAATCAC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 2005 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2162 AA DIVMTQSPDSLSVSLGERATINCKSSQSVLSSSNNK QVPLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPNLLIYWTSTRESGVPDRFSG HWVRQAPGQGLEWMGWISPNNGETNYAQKFQD SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF RVTMTRDTSISTAYMELSRLRSDDTAVYYCAREA GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC TIFGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLA LLNNFYPREAKVQWKVDNALQSGNSQESVTEQDS PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT KDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSS SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC PVTKSFNRGEC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL SEQ ID NO: 435 LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK SEQ ID NO: 592 iPS:361395 12H11.013 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAGCAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAAACTGCTCATTTAC CTTGAGTGGATGGGGTGGATAAGCCCTAACCAA TGGACTTCTACCCGAGATTCCGGGGTCCCTGAC GGTGAAACAAACTATGCACAGAAGTTTCAGGAC CGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGCCTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTACTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGAACGGTGGCTGCACCATCTGTCT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA GTGGATAACGCCCTCCAATCGGGTAACTCCCAG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC GAGAGTGTCACAGAGCAGGACAGCAAGGACAG AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC CACCTACAGCCTCAGCAGCACCCTGACGCTGAG GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC CAAAGCAGACTACGAGAAACACAAAGTCTACG AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC GGCACCCAGACCTACATCTGCAACGTGAATCAC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 2006 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2163 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPKLLIYWTSTRDSGVPDRFSG HWVRQAPGQGLEWMGWISPNQGETNYAQKFQD SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF RVTMTRDTSISTAYMELSSLRSDDTAVYYCAREA GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC TIFGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLA LLNNFYPREAKVQWKVDNALQSGNSQESVTEQDS PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT KDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSS SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC PVTKSFNRGEC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL SEQ ID NO: 436 LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK SEQ ID NO: 593 iPS:361402 12H11.014 NA GACATCGTGATGACCCAGTCTCCAGACTCCCTG CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTG GCTGTGTCTCTGGGCGAGAGGGCCACCATCAAC AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC TGCAAGTCCAGCCAGAGTGTTTTATCCAGCTCC AAGGCTTCTGGATACACCTTCACCGGCTACTAT AACAATAAGAACTACTTAGCTTGGTACCAGCAG ATACACTGGGTGCGTCAGGCCCCTGGACAAGGG AAACCAGGACAGCCTCCTAAACTGCTCATTTAC CTTGAGTGGATGGGGTGGATAAGCCCTAACCAA TGGACTTCTACCCGAGAATCCGGGGTCCCTGAC GGTGAAACAAACTATGCACAGAAGTTTCAGGAC ACGATTCAGTGGCAGCGGGTCTGGGACAGATTTC AGGGTCACCATGACCAGGGACACGTCCATCAGC ACTCTCACCATCAACAGCCTGCAGGCTGAAGAT ACAGCCTATATGGAGCTGAGCAGCCTGAGATCT GTGGCTGTTTATTACTGTCAGCAATATTATCGTA GACGACACGGCCGTGTATTACTGTGCGAGAGAG CTCCGTGGACGTTCGGCCAAGGGACCAAGGTGG GCCACGATTTTTGGAATGCTTATTGTACCATTTG AAATCAAACGAACGGTGGCTGCACCATCTGTCT ACTACTGGGGCCAGGGAACCCTGGTCACCGTCT TCATCTTCCCGCCATCTGATGAGCAGTTGAAATC CCTCAGCCTCCACCAAGGGCCCATCGGTCTTCCC TGGAACTGCCTCTGTTGTGTGCCTGCTGAATAAC CCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG TTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG CACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA GTGGATAACGCCCTCCAATCGGGTAACTCCCAG CTTCCCCGAACCGGTGACGGTGTCGTGGAACTC GAGAGTGTCACAGAGCAGGACAGCAAGGACAG AGGCGCCCTGACCAGCGGCGTGCACACCTTCCC CACCTACAGCCTCAGCAGCACCCTGACGCTGAG GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTC CAAAGCAGACTACGAGAAACACAAAGTCTACG AGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGC GGCACCCAGACCTACATCTGCAACGTGAATCAC CCGTCACAAAGAGCTTCAACAGGGGAGAGTGT AAGCCCAGCAACACCAAGGTGGACAAGAAAGT SEQ ID NO: 2007 TGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAACTCCTGGGGGG ACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTC ACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGC GTGGAGGTGCATAATGCCAAGACAAAGCCGTGT GAGGAGCAGTACGGCAGCACGTACCGTTGTGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCAAGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATC TCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCATCCCGGGAGGAGAT GACCAAGAACCAGGTCAGCCTGACCTGCCTGGT CAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGA CAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTC ATGCTCCGTGATGCATGAGGCTCTGCACAACCA CTACACGCAGAAGAGCCTCTCCCTGTCTCCGGG TAAA SEQ ID NO: 2164 AA DIVMTQSPDSLAVSLGERATINCKSSQSVLSSSNNK QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYI NYLAWYQQKPGQPPKLLIYWTSTRESGVPDRFSG HWVRQAPGQGLEWMGWISPNQGETNYAQKFQD SGSGTDFTLTINSLQAEDVAVYYCQQYYRTPWTF RVTMTRDTSISTAYMELSSLRSDDTAVYYCAREA GQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVC TIFGMLIVPFDYWGQGTLVTVSSASTKGPSVFPLA LLNNFYPREAKVQWKVDNALQSGNSQESVTEQDS PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALT KDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSS SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC PVTKSFNRGEC NVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL SEQ ID NO: 437 LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRC VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK SEQ ID NO: 594 iPS:361406 2C2.005.001 NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGTAGCTCCAACATCGGAAGTCAAACTG AAGGCTTCCGGATACACCTTCACCGGCTACTAT TAAACTGGTACCAGCACCTCCCAGGAACGGCCC ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATCTATACTAATAATCAGCGGC CTTGAGTGGATGGGATGGATCAACCCTAACAGT CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GGTGGCACAAACTATGCACAGAAGTTTCAGGGC GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG AGGGTCACCATGACCAGGGACACGTCCATCAGT CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT CAACATTCGATGAAAGCCTGAGTGGTCCGGTAT GACGACACGGCCGTGTATTACTGTGCGAGAGGG TCGGCGGAGGGACCAAGCTGACCGTCCTAGGTC GGGGATTACGTTTGGGGGACTTATCGGCCTCAC AGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCC TACTACTACGGTATGGACGTCTGGGGCCAAGGG GCCCTCCTCTGAGGAGCTTCAAGCCAACAAGGC ACCACGGTCACCGTCTCCTCAGCCTCCACCAAG CACACTGGTGTGTCTCATAAGTGACTTCTACCCG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCA GGAGCCGTGACAGTGGCCTGGAAGGCAGATAG AGAGCACCTCTGGGGGCACAGCGGCCCTGGGCT CAGCCCCGTCAAGGCGGGAGTGGAGACCACCAC GCCTGGTCAAGGACTACTTCCCCGAACCGGTGA ACCCTCCAAACAAAGCAACAACAAGTACGCGGC CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCG CAGCAGCTATCTGAGCCTGACGCCTGAGCAGTG GCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC GAAGTCCCACAGAAGCTACAGCTGCCAGGTCAC AGGACTCTACTCCCTCAGCAGCGTGGTGACCGT GCATGAAGGGAGCACCGTGGAGAAGACAGTGG GCCCTCCAGCAGCTTGGGCACCCAGACCTACAT CCCCTACAGAATGTTCA CTGCAACGTGAATCACAAGCCCAGCAACACCAA SEQ ID NO: 2008 GGTGGACAAGAAAGTTGAGCCCAAATCTTGTGA CAAAACTCACACATGCCCACCGTGCCCAGCACC TGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTC CCCCCAAAACCCAAGGACACCCTCATGATCTCC CGGACCCCTGAGGTCACATGCGTGGTGGTGGAC GTGAGCCACGAAGACCCTGAGGTCAAGTTCAAC TGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGTGTGAGGAGCAGTACGGCAG CACGTACCGTTGTGTCAGCGTCCTCACCGTCCTG CACCAGGACTGGCTGAATGGCAAGGAGTACAA GTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACCACAGGTGTACACCCTGCCCCC ATCCCGGGAGGAGATGACCAAGAACCAGGTCA GCCTGACCTGCCTGGTCAAAGGCTTCTATCCCA GCGACATCGCCGTGGAGTGGGAGAGCAATGGG CAGCCGGAGAACAACTACAAGACCACGCCTCCC GTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAG CAGGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCTCTGCACAACCACTACACGCAGAAGAGC CTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2165 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSQTVNW QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ ASLAISGLQSEDEADYFCATFDESLSGPVFGGGTK GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG LTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISD GDYVWGTYRPHYYYGMDVWGQGTTVTVSSAST FYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKY KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT AASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTV VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS APTECS SSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH SEQ ID NO: 438 TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO: 595 iPS:361412 2C2.005.002 NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGTAGCTCCAACATCGGAAGTCAAACTG AAGGCTTCCGGATACACCTTCACCGGCTACTAT TAAACTGGTACCAGCACCTCCCAGGAACGGCCC ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATCTATACTAATAATCAGCGGC CTTGAGTGGATGGGATGGATCAACCCTAACAGT CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GGTGGCACAAACTATGCACAGAAGTTTCAGGGC GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG AGGGTCACCATGACCAGGGACACGTCCATCAGT CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT ACAACATTCGATGAAAGCCTGCAAGGTCCGGTAT GACGACACGGCCGTGTATTACTGTGCGAGAGGG TCGGCGGAGGGACCAAGCTGACCGTCCTAGGTC GGGGATTACGTTTGGGGGACTTATCGGCCTCAC AGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCC TACTACTACGGTATGGACGTCTGGGGCCAAGGG GCCCTCCTCTGAGGAGCTTCAAGCCAACAAGGC ACCACGGTCACCGTCTCCTCAGCCTCCACCAAG CACACTGGTGTGTCTCATAAGTGACTTCTACCCG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCA GGAGCCGTGACAGTGGCCTGGAAGGCAGATAG AGAGCACCTCTGGGGGCACAGCGGCCCTGGGCT CAGCCCCGTCAAGGCGGGAGTGGAGACCACCAC GCCTGGTCAAGGACTACTTCCCCGAACCGGTGA ACCCTCCAAACAAAGCAACAACAAGTACGCGGC CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCG CAGCAGCTATCTGAGCCTGACGCCTGAGCAGTG GCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC GAAGTCCCACAGAAGCTACAGCTGCCAGGTCAC AGGACTCTACTCCCTCAGCAGCGTGGTGACCGT GCATGAAGGGAGCACCGTGGAGAAGACAGTGG GCCCTCCAGCAGCTTGGGCACCCAGACCTACAT CCCCTACAGAATGTTCA CTGCAACGTGAATCACAAGCCCAGCAACACCAA SEQ ID NO: 2009 GGTGGACAAGAAAGTTGAGCCCAAATCTTGTGA CAAAACTCACACATGCCCACCGTGCCCAGCACC TGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTC CCCCCAAAACCCAAGGACACCCTCATGATCTCC CGGACCCCTGAGGTCACATGCGTGGTGGTGGAC GTGAGCCACGAAGACCCTGAGGTCAAGTTCAAC TGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGTGTGAGGAGCAGTACGGCAG CACGTACCGTTGTGTCAGCGTCCTCACCGTCCTG CACCAGGACTGGCTGAATGGCAAGGAGTACAA GTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACCACAGGTGTACACCCTGCCCCC ATCCCGGGAGGAGATGACCAAGAACCAGGTCA GCCTGACCTGCCTGGTCAAAGGCTTCTATCCCA GCGACATCGCCGTGGAGTGGGAGAGCAATGGG CAGCCGGAGAACAACTACAAGACCACGCCTCCC GTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAG CAGGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCTCTGCACAACCACTACACGCAGAAGAGC CTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2166 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSQTVNW QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ ASLAISGLQSEDEADYFCATFDESLQGPVFGGGTKG RVTMTRDTSISTAYMELSRLRSDDTAVYYCARG LTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISD GDYVWGTYRPHYYYGMDVWGQGTTVTVSSAST FYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKY KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT AASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTV VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS APTECS SSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH SEQ ID NO: 439 TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO: 596 iPS:361418 2C2.005.003 NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGTAGCTCCAACATCGGAAGTAATTATG AAGGCTTCCGGATACACCTTCACCGGCTACTAT TAAACTGGTACCAGCACCTCCCAGGAACGGCCC ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATCTATACTAATAATCAGCGGC CTTGAGTGGATGGGATGGATCAACCCTAACAGT CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GGTGGCACAAACTATGCACAGAAGTTTCAGGGC GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG AGGGTCACCATGACCAGGGACACGTCCATCAGT CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT CAACATTCGATGAAAGCCTGAGTGGTCCGGTAT GACGACACGGCCGTGTATTACTGTGCGAGAGGG TCGGCGGAGGGACCAAGCTGACCGTCCTAGGTC GGGGATTACGTTTGGGGGACTTATCGGCCTCAC AGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCC TACTACTACGGTATGGACGTCTGGGGCCAAGGG GCCCTCCTCTGAGGAGCTTCAAGCCAACAAGGC ACCACGGTCACCGTCTCCTCAGCCTCCACCAAG CACACTGGTGTGTCTCATAAGTGACTTCTACCCG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCA GGAGCCGTGACAGTGGCCTGGAAGGCAGATAG AGAGCACCTCTGGGGGCACAGCGGCCCTGGGCT CAGCCCCGTCAAGGCGGGAGTGGAGACCACCAC GCCTGGTCAAGGACTACTTCCCCGAACCGGTGA ACCCTCCAAACAAAGCAACAACAAGTACGCGGC CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCG CAGCAGCTATCTGAGCCTGACGCCTGAGCAGTG GCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC GAAGTCCCACAGAAGCTACAGCTGCCAGGTCAC AGGACTCTACTCCCTCAGCAGCGTGGTGACCGT GCATGAAGGGAGCACCGTGGAGAAGACAGTGG GCCCTCCAGCAGCTTGGGCACCCAGACCTACAT CCCCTACAGAATGTTCA CTGCAACGTGAATCACAAGCCCAGCAACACCAA SEQ ID NO: 2010 GGTGGACAAGAAAGTTGAGCCCAAATCTTGTGA CAAAACTCACACATGCCCACCGTGCCCAGCACC TGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTC CCCCCAAAACCCAAGGACACCCTCATGATCTCC CGGACCCCTGAGGTCACATGCGTGGTGGTGGAC GTGAGCCACGAAGACCCTGAGGTCAAGTTCAAC TGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGTGTGAGGAGCAGTACGGCAG CACGTACCGTTGTGTCAGCGTCCTCACCGTCCTG CACCAGGACTGGCTGAATGGCAAGGAGTACAA GTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACCACAGGTGTACACCCTGCCCCC ATCCCGGGAGGAGATGACCAAGAACCAGGTCA GCCTGACCTGCCTGGTCAAAGGCTTCTATCCCA GCGACATCGCCGTGGAGTGGGAGAGCAATGGG CAGCCGGAGAACAACTACAAGACCACGCCTCCC GTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAG CAGGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCTCTGCACAACCACTACACGCAGAAGAGC CTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2167 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNYVNW QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ ASLAISGLQSEDEADYFCATFDESLSGPVFGGGTK GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG LTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISD GDYVWGTYRPHYYYGMDVWGQGTTVTVSSAST FYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKY KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT AASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTV VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS APTECS SSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH SEQ ID NO: 440 TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO: 597 iPS:361424 2C2.005.004 NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGTAGCTCCAACATCGGAAGTAATTATG AAGGCTTCCGGATACACCTTCACCGGCTACTAT TAAACTGGTACCAGCACCTCCCAGGAACGGCCC ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATCTATACTAATAATCAGCGGC CTTGAGTGGATGGGATGGATCAACCCTAACAGT CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GGTGGCACAAACTATGCACAGAAGTTTCAGGGC GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG AGGGTCACCATGACCAGGGACACGTCCATCAGT CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT CAACATTCGATGAAAGCCTGCAAGGTCCGGTAT GACGACACGGCCGTGTATTACTGTGCGAGAGGG ATCGGCGGAGGGACCAAGCTGACCGTCCTAGGTC GGGGATTACGTTTGGGGGACTTATCGGCCTCAC AGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCC TACTACTACGGTATGGACGTCTGGGGCCAAGGG GCCCTCCTCTGAGGAGCTTCAAGCCAACAAGGC ACCACGGTCACCGTCTCCTCAGCCTCCACCAAG CACACTGGTGTGTCTCATAAGTGACTTCTACCCG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCA GGAGCCGTGACAGTGGCCTGGAAGGCAGATAG AGAGCACCTCTGGGGGCACAGCGGCCCTGGGCT CAGCCCCGTCAAGGCGGGAGTGGAGACCACCAC GCCTGGTCAAGGACTACTTCCCCGAACCGGTGA ACCCTCCAAACAAAGCAACAACAAGTACGCGGC CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCG CAGCAGCTATCTGAGCCTGACGCCTGAGCAGTG GCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC GAAGTCCCACAGAAGCTACAGCTGCCAGGTCAC AGGACTCTACTCCCTCAGCAGCGTGGTGACCGT GCATGAAGGGAGCACCGTGGAGAAGACAGTGG GCCCTCCAGCAGCTTGGGCACCCAGACCTACAT CCCCTACAGAATGTTCA CTGCAACGTGAATCACAAGCCCAGCAACACCAA SEQ ID NO: 2011 GGTGGACAAGAAAGTTGAGCCCAAATCTTGTGA CAAAACTCACACATGCCCACCGTGCCCAGCACC TGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTC CCCCCAAAACCCAAGGACACCCTCATGATCTCC CGGACCCCTGAGGTCACATGCGTGGTGGTGGAC GTGAGCCACGAAGACCCTGAGGTCAAGTTCAAC TGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGTGTGAGGAGCAGTACGGCAG CACGTACCGTTGTGTCAGCGTCCTCACCGTCCTG CACCAGGACTGGCTGAATGGCAAGGAGTACAA GTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACCACAGGTGTACACCCTGCCCCC ATCCCGGGAGGAGATGACCAAGAACCAGGTCA GCCTGACCTGCCTGGTCAAAGGCTTCTATCCCA GCGACATCGCCGTGGAGTGGGAGAGCAATGGG CAGCCGGAGAACAACTACAAGACCACGCCTCCC GTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAG CAGGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCTCTGCACAACCACTACACGCAGAAGAGC CTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2168 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNYVNW QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ ASLAISGLQSEDEADYFCATFDESLQGPVFGGGTK GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG LTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISD GDYVWGTYRPHYYYGMDVWGQGTTVTVSSAST FYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKY KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT AASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTV VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS APTECS SSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH SEQ ID NO: 441 TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO: 598 iPS:361430 2C2.005.005 NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGTAGCTCCAACATCGGAAGTCAAACTG AAGGCTTCCGGATACACCTTCACCGGCTACTAT TAAACTGGTACCAGCACCTCCCAGGAACGGCCC ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATCTATACTAATAATCAGCGGC CTTGAGTGGATGGGATGGATCAACCCTAACAGT CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GGTGGCACAAACTATGCACAGAAGTTTCAGGGC GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG AGGGTCACCATGACCAGGGACACGTCCATCAGT CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT CAACATTCGATGACAGCCTGAATGGTCCGGTAT GACGACACGGCCGTGTATTACTGTGCGAGAGGG TCGGCGGAGGGACCAAGCTGACCGTCCTAGGTC GGGGATTACGTTTGGGGGACTTATCGGCCTCAC AGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCC TACTACTACGGTATGGACGTCTGGGGCCAAGGG GCCCTCCTCTGAGGAGCTTCAAGCCAACAAGGC ACCACGGTCACCGTCTCCTCAGCCTCCACCAAG CACACTGGTGTGTCTCATAAGTGACTTCTACCCG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCA GGAGCCGTGACAGTGGCCTGGAAGGCAGATAG AGAGCACCTCTGGGGGCACAGCGGCCCTGGGCT CAGCCCCGTCAAGGCGGGAGTGGAGACCACCAC GCCTGGTCAAGGACTACTTCCCCGAACCGGTGA ACCCTCCAAACAAAGCAACAACAAGTACGCGGC CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCG CAGCAGCTATCTGAGCCTGACGCCTGAGCAGTG GCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC GAAGTCCCACAGAAGCTACAGCTGCCAGGTCAC AGGACTCTACTCCCTCAGCAGCGTGGTGACCGT GCATGAAGGGAGCACCGTGGAGAAGACAGTGG GCCCTCCAGCAGCTTGGGCACCCAGACCTACAT CCCCTACAGAATGTTCA CTGCAACGTGAATCACAAGCCCAGCAACACCAA SEQ ID NO: 2012 GGTGGACAAGAAAGTTGAGCCCAAATCTTGTGA CAAAACTCACACATGCCCACCGTGCCCAGCACC TGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTC CCCCCAAAACCCAAGGACACCCTCATGATCTCC CGGACCCCTGAGGTCACATGCGTGGTGGTGGAC GTGAGCCACGAAGACCCTGAGGTCAAGTTCAAC TGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGTGTGAGGAGCAGTACGGCAG CACGTACCGTTGTGTCAGCGTCCTCACCGTCCTG CACCAGGACTGGCTGAATGGCAAGGAGTACAA GTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACCACAGGTGTACACCCTGCCCCC ATCCCGGGAGGAGATGACCAAGAACCAGGTCA GCCTGACCTGCCTGGTCAAAGGCTTCTATCCCA GCGACATCGCCGTGGAGTGGGAGAGCAATGGG CAGCCGGAGAACAACTACAAGACCACGCCTCCC GTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAG CAGGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCTCTGCACAACCACTACACGCAGAAGAGC CTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2169 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSQTVNW QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ ASLAISGLQSEDEADYFCATFDDSLNGPVFGGGTK GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG LTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISD GDYVWGTYRPHYYYGMDVWGQGTTVTVSSAST FYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKY KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT AASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTV VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS APTECS SSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH SEQ ID NO: 442 TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO: 599 iPS:361436 2C2.005.006 NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGTAGCTCCAACATCGGAAGTAATTATG AAGGCTTCCGGATACACCTTCACCGGCTACTAT TAAACTGGTACCAGCACCTCCCAGGAACGGCCC ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATCTATACTAATAATCAGCGGC CTTGAGTGGATGGGATGGATCAACCCTAACAGT CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GGTGGCACAAACTATGCACAGAAGTTTCAGGGC GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG AGGGTCACCATGACCAGGGACACGTCCATCAGT CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT CAACATTCGATGACAGCCTGAATGGTCCGGTAT GACGACACGGCCGTGTATTACTGTGCGAGAGGG TCGGCGGAGGGACCAAGCTGACCGTCCTAGGTC GGGGATTACGTTTGGGGGACTTATCGGCCTCAC AGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCC TACTACTACGGTATGGACGTCTGGGGCCAAGGG AGCCCTCCTCTGAGGAGCTTCAAGCCAACAAGGC ACCACGGTCACCGTCTCCTCAGCCTCCACCAAG CACACTGGTGTGTCTCATAAGTGACTTCTACCCG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCA GGAGCCGTGACAGTGGCCTGGAAGGCAGATAG AGAGCACCTCTGGGGGCACAGCGGCCCTGGGCT CAGCCCCGTCAAGGCGGGAGTGGAGACCACCAC GCCTGGTCAAGGACTACTTCCCCGAACCGGTGA ACCCTCCAAACAAAGCAACAACAAGTACGCGGC CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCG CAGCAGCTATCTGAGCCTGACGCCTGAGCAGTG GCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC GAAGTCCCACAGAAGCTACAGCTGCCAGGTCAC AGGACTCTACTCCCTCAGCAGCGTGGTGACCGT GCATGAAGGGAGCACCGTGGAGAAGACAGTGG GCCCTCCAGCAGCTTGGGCACCCAGACCTACAT CCCCTACAGAATGTTCA CTGCAACGTGAATCACAAGCCCAGCAACACCAA SEQ ID NO: 2013 GGTGGACAAGAAAGTTGAGCCCAAATCTTGTGA CAAAACTCACACATGCCCACCGTGCCCAGCACC TGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTC CCCCCAAAACCCAAGGACACCCTCATGATCTCC CGGACCCCTGAGGTCACATGCGTGGTGGTGGAC GTGAGCCACGAAGACCCTGAGGTCAAGTTCAAC TGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGTGTGAGGAGCAGTACGGCAG CACGTACCGTTGTGTCAGCGTCCTCACCGTCCTG CACCAGGACTGGCTGAATGGCAAGGAGTACAA GTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACCACAGGTGTACACCCTGCCCCC ATCCCGGGAGGAGATGACCAAGAACCAGGTCA GCCTGACCTGCCTGGTCAAAGGCTTCTATCCCA GCGACATCGCCGTGGAGTGGGAGAGCAATGGG CAGCCGGAGAACAACTACAAGACCACGCCTCCC GTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAG CAGGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCTCTGCACAACCACTACACGCAGAAGAGC CTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2170 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNYVNW QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ ASLAISGLQSEDEADYFCATFDDSLNGPVFGGGTK GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG LTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISD GDYVWGTYRPHYYYGMDVWGQGTTVTVSSAST FYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKY KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT AASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTV VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS APTECS SSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH SEQ ID NO: 443 TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO: 600 iPS:361442 2C2.005.007 NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGTAGCTCCAACATCGGAAGTAATACTG AAGGCTTCCGGATACACCTTCACCGGCTACTAT TAAACTGGTACCAGCACCTCCCAGGAACGGCCC ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATCTATACTAATAATCAGCGGC CTTGAGTGGATGGGATGGATCAACCCTAACAGT CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GGTGGCACAAACTATGCACAGAAGTTTCAGGGC GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG AGGGTCACCATGACCAGGGACACGTCCATCAGT CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT CAACATTCGATGAAAGCCTGAATGGTCCGGTAT GACGACACGGCCGTGTATTACTGTGCGAGAGGG TCGGCGGAGGGACCAAGCTGACCGTCCTAGGTC GGGGATTACGTTTGGGGGACTTATCGGCCTCAC AGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCC TACTACTACGGTATGGACGTCTGGGGCCAAGGG GCCCTCCTCTGAGGAGCTTCAAGCCAACAAGGC ACCACGGTCACCGTCTCCTCAGCCTCCACCAAG CACACTGGTGTGTCTCATAAGTGACTTCTACCCG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCA GGAGCCGTGACAGTGGCCTGGAAGGCAGATAG AGAGCACCTCTGGGGGCACAGCGGCCCTGGGCT CAGCCCCGTCAAGGCGGGAGTGGAGACCACCAC GCCTGGTCAAGGACTACTTCCCCGAACCGGTGA ACCCTCCAAACAAAGCAACAACAAGTACGCGGC CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCG CAGCAGCTATCTGAGCCTGACGCCTGAGCAGTG GCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC GAAGTCCCACAGAAGCTACAGCTGCCAGGTCAC AGGACTCTACTCCCTCAGCAGCGTGGTGACCGT GCATGAAGGGAGCACCGTGGAGAAGACAGTGG GCCCTCCAGCAGCTTGGGCACCCAGACCTACAT CCCCTACAGAATGTTCA CTGCAACGTGAATCACAAGCCCAGCAACACCAA SEQ ID NO: 2014 GGTGGACAAGAAAGTTGAGCCCAAATCTTGTGA CAAAACTCACACATGCCCACCGTGCCCAGCACC TGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTC CCCCCAAAACCCAAGGACACCCTCATGATCTCC CGGACCCCTGAGGTCACATGCGTGGTGGTGGAC GTGAGCCACGAAGACCCTGAGGTCAAGTTCAAC TGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGTGTGAGGAGCAGTACGGCAG CACGTACCGTTGTGTCAGCGTCCTCACCGTCCTG CACCAGGACTGGCTGAATGGCAAGGAGTACAA GTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACCACAGGTGTACACCCTGCCCCC ATCCCGGGAGGAGATGACCAAGAACCAGGTCA GCCTGACCTGCCTGGTCAAAGGCTTCTATCCCA GCGACATCGCCGTGGAGTGGGAGAGCAATGGG CAGCCGGAGAACAACTACAAGACCACGCCTCCC GTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAG CAGGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCTCTGCACAACCACTACACGCAGAAGAGC CTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2171 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNW QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ ASLAISGLQSEDEADYFCATFDESLNGPVFGGGTK GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG LTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISD GDYVWGTYRPHYYYGMDVWGQGTTVTVSSAST FYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKY KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT AASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTV VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS APTECS SSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH SEQ ID NO: 444 TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO: 601 iPS:361448 2C2.005.008 NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGTAGCTCCAACATCGGAAGTAATACTG AAGGCTTCCGGATACACCTTCACCGGCTACTAT TAAACTGGTACCAGCACCTCCCAGGAACGGCCC ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG ACCAAACTCCTCATCTATACTAATAATCAGCGGC CTTGAGTGGATGGGATGGATCAACCCTAACAGT CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GGTGGCACAAACTATGCACAGAAGTTTCAGGGC GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG AGGGTCACCATGACCAGGGACACGTCCATCAGT CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT CAACATTCGATGACAGCCTGCAAGGTCCGGTAT GACGACACGGCCGTGTATTACTGTGCGAGAGGG TCGGCGGAGGGACCAAGCTGACCGTCCTAGGTC GGGGATTACGTTTGGGGGACTTATCGGCCTCAC AGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCC TACTACTACGGTATGGACGTCTGGGGCCAAGGG GCCCTCCTCTGAGGAGCTTCAAGCCAACAAGGC ACCACGGTCACCGTCTCCTCAGCCTCCACCAAG CACACTGGTGTGTCTCATAAGTGACTTCTACCCG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCA GGAGCCGTGACAGTGGCCTGGAAGGCAGATAG AGAGCACCTCTGGGGGCACAGCGGCCCTGGGCT CAGCCCCGTCAAGGCGGGAGTGGAGACCACCAC GCCTGGTCAAGGACTACTTCCCCGAACCGGTGA ACCCTCCAAACAAAGCAACAACAAGTACGCGGC CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCG CAGCAGCTATCTGAGCCTGACGCCTGAGCAGTG GCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC GAAGTCCCACAGAAGCTACAGCTGCCAGGTCAC AGGACTCTACTCCCTCAGCAGCGTGGTGACCGT GCATGAAGGGAGCACCGTGGAGAAGACAGTGG GCCCTCCAGCAGCTTGGGCACCCAGACCTACAT CCCCTACAGAATGTTCA CTGCAACGTGAATCACAAGCCCAGCAACACCAA SEQ ID NO: 2015 GGTGGACAAGAAAGTTGAGCCCAAATCTTGTGA CAAAACTCACACATGCCCACCGTGCCCAGCACC TGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTC CCCCCAAAACCCAAGGACACCCTCATGATCTCC CGGACCCCTGAGGTCACATGCGTGGTGGTGGAC GTGAGCCACGAAGACCCTGAGGTCAAGTTCAAC TGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGTGTGAGGAGCAGTACGGCAG CACGTACCGTTGTGTCAGCGTCCTCACCGTCCTG CACCAGGACTGGCTGAATGGCAAGGAGTACAA GTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACCACAGGTGTACACCCTGCCCCC ATCCCGGGAGGAGATGACCAAGAACCAGGTCA GCCTGACCTGCCTGGTCAAAGGCTTCTATCCCA GCGACATCGCCGTGGAGTGGGAGAGCAATGGG CAGCCGGAGAACAACTACAAGACCACGCCTCCC GTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAG CAGGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCTCTGCACAACCACTACACGCAGAAGAGC CTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2172 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNW QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ ASLAISGLQSEDEADYFCATFDDSLQGPVFGGGTK GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG LTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISD GDYVWGTYRPHYYYGMDVWGQGTTVTVSSAST FYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKY KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT AASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTV VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS APTECS SSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH SEQ ID NO: 445 TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO: 602 iPS:361454 2C2.005.009 NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGTAGCTCCAACATCGGAAGTAATACTG AAGGCTTCCGGATACACCTTCACCGGCTACTAT TAAACTGGTACCAGCACCTCCCAGGAACGGCCC ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATCTATACTAATAATCAGCGGC CTTGAGTGGATGGGATGGATCAACCCTAACAGT CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GGTGGCACAAACTATGCACAGAAGTTTCAGGGC GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG AGGGTCACCATGACCAGGGACACGTCCATCAGT CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT CAACATTCGATGACAGCCTGAGTGGTCCGGTAT GACGACACGGCCGTGTATTACTGTGCGAGAGGG TCGGCGGAGGGACCAAGCTGACCGTCCTAGGTC GGGGATTACGTTTGGGGGACTTATCGGCCTCAC AGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCC TACTACTACGGTATGGACGTCTGGGGCCAAGGG GCCCTCCTCTGAGGAGCTTCAAGCCAACAAGGC ACCACGGTCACCGTCTCCTCAGCCTCCACCAAG CACACTGGTGTGTCTCATAAGTGACTTCTACCCG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCA GGAGCCGTGACAGTGGCCTGGAAGGCAGATAG AGAGCACCTCTGGGGGCACAGCGGCCCTGGGCT CAGCCCCGTCAAGGCGGGAGTGGAGACCACCAC GCCTGGTCAAGGACTACTTCCCCGAACCGGTGA ACCCTCCAAACAAAGCAACAACAAGTACGCGGC CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCG CAGCAGCTATCTGAGCCTGACGCCTGAGCAGTG GCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC GAAGTCCCACAGAAGCTACAGCTGCCAGGTCAC AGGACTCTACTCCCTCAGCAGCGTGGTGACCGT GCATGAAGGGAGCACCGTGGAGAAGACAGTGG GCCCTCCAGCAGCTTGGGCACCCAGACCTACAT CCCCTACAGAATGTTCA CTGCAACGTGAATCACAAGCCCAGCAACACCAA SEQ ID NO: 2016 GGTGGACAAGAAAGTTGAGCCCAAATCTTGTGA CAAAACTCACACATGCCCACCGTGCCCAGCACC TGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTC CCCCCAAAACCCAAGGACACCCTCATGATCTCC CGGACCCCTGAGGTCACATGCGTGGTGGTGGAC GTGAGCCACGAAGACCCTGAGGTCAAGTTCAAC TGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGTGTGAGGAGCAGTACGGCAG CACGTACCGTTGTGTCAGCGTCCTCACCGTCCTG CACCAGGACTGGCTGAATGGCAAGGAGTACAA GTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACCACAGGTGTACACCCTGCCCCC ATCCCGGGAGGAGATGACCAAGAACCAGGTCA GCCTGACCTGCCTGGTCAAAGGCTTCTATCCCA GCGACATCGCCGTGGAGTGGGAGAGCAATGGG CAGCCGGAGAACAACTACAAGACCACGCCTCCC GTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAG CAGGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCTCTGCACAACCACTACACGCAGAAGAGC CTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2173 iPS:361460 2C2.005.010 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNW QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ ASLAISGLQSEDEADYFCATFDDSLSGPVFGGGTKG RVTMTRDTSISTAYMELSRLRSDDTAVYYCARG LTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISD GDYVWGTYRPHYYYGMDVWGQGTTVTVSSAST FYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKY KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT AASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTV VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS APTECS SSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH SEQ ID NO: 446 TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO: 603 iPS:361460 2C2.005.010 NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGTAGCTCCAACATCGGAAGTAATACTG AAGGCTTCCGGATACACCTTCACCGGCTACTAT TAAACTGGTACCAGCACCTCCCAGGAACGGCCC ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATCTATACTAATAATCAGCGGC CTTGAGTGGATGGGATGGATCAACCCTAACAGT CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GGTGGCACAAACTATGCACAGAAGTTTCAGGGC GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG AGGGTCACCATGACCAGGGACACGTCCATCAGT CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT CAACATTCGATGACAGCCTGAATGCTCCGGTAT GACGACACGGCCGTGTATTACTGTGCGAGAGGG TCGGCGGAGGGACCAAGCTGACCGTCCTAGGTC GGGGATTACGTTTGGGGGACTTATCGGCCTCAC AGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCC TACTACTACGGTATGGACGTCTGGGGCCAAGGG GCCCTCCTCTGAGGAGCTTCAAGCCAACAAGGC ACCACGGTCACCGTCTCCTCAGCCTCCACCAAG CACACTGGTGTGTCTCATAAGTGACTTCTACCCG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCA GGAGCCGTGACAGTGGCCTGGAAGGCAGATAG AGAGCACCTCTGGGGGCACAGCGGCCCTGGGCT CAGCCCCGTCAAGGCGGGAGTGGAGACCACCAC GCCTGGTCAAGGACTACTTCCCCGAACCGGTGA ACCCTCCAAACAAAGCAACAACAAGTACGCGGC CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCG CAGCAGCTATCTGAGCCTGACGCCTGAGCAGTG GCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC GAAGTCCCACAGAAGCTACAGCTGCCAGGTCAC AGGACTCTACTCCCTCAGCAGCGTGGTGACCGT GCATGAAGGGAGCACCGTGGAGAAGACAGTGG GCCCTCCAGCAGCTTGGGCACCCAGACCTACAT CCCCTACAGAATGTTCA CTGCAACGTGAATCACAAGCCCAGCAACACCAA SEQ ID NO: 2017 GGTGGACAAGAAAGTTGAGCCCAAATCTTGTGA CAAAACTCACACATGCCCACCGTGCCCAGCACC TGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTC CCCCCAAAACCCAAGGACACCCTCATGATCTCC CGGACCCCTGAGGTCACATGCGTGGTGGTGGAC GTGAGCCACGAAGACCCTGAGGTCAAGTTCAAC TGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGTGTGAGGAGCAGTACGGCAG CACGTACCGTTGTGTCAGCGTCCTCACCGTCCTG CACCAGGACTGGCTGAATGGCAAGGAGTACAA GTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACCACAGGTGTACACCCTGCCCCC ATCCCGGGAGGAGATGACCAAGAACCAGGTCA GCCTGACCTGCCTGGTCAAAGGCTTCTATCCCA GCGACATCGCCGTGGAGTGGGAGAGCAATGGG CAGCCGGAGAACAACTACAAGACCACGCCTCCC GTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAG CAGGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCTCTGCACAACCACTACACGCAGAAGAGC CTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2174 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNW QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ ASLAISGLQSEDEADYFCATFDDSLNAPVFGGGTK GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG LTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISD GDYVWGTYRPHYYYGMDVWGQGTTVTVSSAST FYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKY KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT AASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTV VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS APTECS SSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH SEQ ID NO: 447 TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO: 604 iPS:361466 2C2.005.011 NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGTAGCTCCAACATCGGAAGTAATACTG AAGGCTTCCGGATACACCTTCACCGGCTACTAT TAAACTGGTACCAGCACCTCCCAGGAACGGCCC ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATCTATACTAATAATCAGCGGC CTTGAGTGGATGGGATGGATCAACCCTAACAGT CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GGTGGCACAAACTATGCACAGAAGTTTCAGGGC GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG AGGGTCACCATGACCAGGGACACGTCCATCAGT CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT CAACATTCGATAGCAGCCTGAATGGTCCGGTAT GACGACACGGCCGTGTATTACTGTGCGAGAGGG TCGGCGGAGGGACCAAGCTGACCGTCCTAGGTC GGGGATTACGTTTGGGGGACTTATCGGCCTCAC AGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCC TACTACTACGGTATGGACGTCTGGGGCCAAGGG GCCCTCCTCTGAGGAGCTTCAAGCCAACAAGGC ACCACGGTCACCGTCTCCTCAGCCTCCACCAAG CACACTGGTGTGTCTCATAAGTGACTTCTACCCG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCA GGAGCCGTGACAGTGGCCTGGAAGGCAGATAG AGAGCACCTCTGGGGGCACAGCGGCCCTGGGCT CAGCCCCGTCAAGGCGGGAGTGGAGACCACCAC GCCTGGTCAAGGACTACTTCCCCGAACCGGTGA ACCCTCCAAACAAAGCAACAACAAGTACGCGGC CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCG CAGCAGCTATCTGAGCCTGACGCCTGAGCAGTG GCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC GAAGTCCCACAGAAGCTACAGCTGCCAGGTCAC AGGACTCTACTCCCTCAGCAGCGTGGTGACCGT GCATGAAGGGAGCACCGTGGAGAAGACAGTGG GCCCTCCAGCAGCTTGGGCACCCAGACCTACAT CCCCTACAGAATGTTCA CTGCAACGTGAATCACAAGCCCAGCAACACCAA SEQ ID NO: 2018 GGTGGACAAGAAAGTTGAGCCCAAATCTTGTGA CAAAACTCACACATGCCCACCGTGCCCAGCACC TGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTC CCCCCAAAACCCAAGGACACCCTCATGATCTCC CGGACCCCTGAGGTCACATGCGTGGTGGTGGAC GTGAGCCACGAAGACCCTGAGGTCAAGTTCAAC TGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGTGTGAGGAGCAGTACGGCAG CACGTACCGTTGTGTCAGCGTCCTCACCGTCCTG CACCAGGACTGGCTGAATGGCAAGGAGTACAA GTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACCACAGGTGTACACCCTGCCCCC ATCCCGGGAGGAGATGACCAAGAACCAGGTCA GCCTGACCTGCCTGGTCAAAGGCTTCTATCCCA GCGACATCGCCGTGGAGTGGGAGAGCAATGGG CAGCCGGAGAACAACTACAAGACCACGCCTCCC GTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAG CAGGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCTCTGCACAACCACTACACGCAGAAGAGC CTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2175 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNW QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ ASLAISGLQSEDEADYFCATFDSSLNGPVFGGGTK GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG LTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISD GDYVWGTYRPHYYYGMDVWGQGTTVTVSSAST FYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKY KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT AASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTV VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS APTECS SSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH SEQ ID NO: 448 TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO: 605 iPS:361472 2C2.005.012 NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGTAGCTCCAACATCGGAAGTAATTATG AAGGCTTCCGGATACACCTTCACCGGCTACTAT TAAACTGGTACCAGCACCTCCCAGGAACGGCCC ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATCTATACTAATAATCAGCGGC CTTGAGTGGATGGGATGGATCAACCCTAACAGT CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GGTGGCACAAACTATGCACAGAAGTTTCAGGGC GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG AGGGTCACCATGACCAGGGACACGTCCATCAGT ACTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT CAACATTCGATAGCAGCCTGAATGCTCCGGTAT GACGACACGGCCGTGTATTACTGTGCGAGAGGG TCGGCGGAGGGACCAAGCTGACCGTCCTAGGTC GGGGATTACGTTTGGGGGACTTATCGGCCTCAC AGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCC TACTACTACGGTATGGACGTCTGGGGCCAAGGG GCCCTCCTCTGAGGAGCTTCAAGCCAACAAGGC ACCACGGTCACCGTCTCCTCAGCCTCCACCAAG CACACTGGTGTGTCTCATAAGTGACTTCTACCCG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCA GGAGCCGTGACAGTGGCCTGGAAGGCAGATAG AGAGCACCTCTGGGGGCACAGCGGCCCTGGGCT CAGCCCCGTCAAGGCGGGAGTGGAGACCACCAC GCCTGGTCAAGGACTACTTCCCCGAACCGGTGA ACCCTCCAAACAAAGCAACAACAAGTACGCGGC CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCG CAGCAGCTATCTGAGCCTGACGCCTGAGCAGTG GCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC GAAGTCCCACAGAAGCTACAGCTGCCAGGTCAC AGGACTCTACTCCCTCAGCAGCGTGGTGACCGT GCATGAAGGGAGCACCGTGGAGAAGACAGTGG GCCCTCCAGCAGCTTGGGCACCCAGACCTACAT CCCCTACAGAATGTTCA CTGCAACGTGAATCACAAGCCCAGCAACACCAA SEQ ID NO: 2019 GGTGGACAAGAAAGTTGAGCCCAAATCTTGTGA CAAAACTCACACATGCCCACCGTGCCCAGCACC TGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTC CCCCCAAAACCCAAGGACACCCTCATGATCTCC CGGACCCCTGAGGTCACATGCGTGGTGGTGGAC GTGAGCCACGAAGACCCTGAGGTCAAGTTCAAC TGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGTGTGAGGAGCAGTACGGCAG CACGTACCGTTGTGTCAGCGTCCTCACCGTCCTG CACCAGGACTGGCTGAATGGCAAGGAGTACAA GTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACCACAGGTGTACACCCTGCCCCC ATCCCGGGAGGAGATGACCAAGAACCAGGTCA GCCTGACCTGCCTGGTCAAAGGCTTCTATCCCA GCGACATCGCCGTGGAGTGGGAGAGCAATGGG CAGCCGGAGAACAACTACAAGACCACGCCTCCC GTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAG CAGGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCTCTGCACAACCACTACACGCAGAAGAGC CTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2176 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNYVNW QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ ASLAISGLQSEDEADYFCATFDSSLNAPVFGGGTK GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG LTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISD GDYVWGTYRPHYYYGMDVWGQGTTVTVSSAST FYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKY KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT AASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTV VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS APTECS SSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH SEQ ID NO: 449 TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO: 606 iPS:361478 2C2.005.013 NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGTAGCTCCAACATCGGAAGTAATTATG AAGGCTTCCGGATACACCTTCACCGGCTACTAT TAAACTGGTACCAGCACCTCCCAGGAACGGCCC ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATCTATACTAATAATCAGCGGC CTTGAGTGGATGGGATGGATCAACCCTAACAGT CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GGTGGCACAAACTATGCACAGAAGTTTCAGGGC GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG AGGGTCACCATGACCAGGGACACGTCCATCAGT CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG ACAGCCTACATGGAGCTGAGCAGCCTGAGGTCT CAACATTCGATAGCAGCCTGAATGCTCCGGTAT GACGACACGGCCGTGTATTACTGTGCGAGAGGG TCGGCGGAGGGACCAAGCTGACCGTCCTAGGTC GGGGATTACGTTTTCGGGACTTATCGGCCTCACT AGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCC ACTACTACGGTATGGACGTCTGGGGCCAAGGGA GCCCTCCTCTGAGGAGCTTCAAGCCAACAAGGC CCACGGTCACCGTCTCCTCAGCCTCCACCAAGG CACACTGGTGTGTCTCATAAGTGACTTCTACCCG GCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAA GGAGCCGTGACAGTGGCCTGGAAGGCAGATAG GAGCACCTCTGGGGGCACAGCGGCCCTGGGCTG CAGCCCCGTCAAGGCGGGAGTGGAGACCACCAC CCTGGTCAAGGACTACTTCCCCGAACCGGTGAC ACCCTCCAAACAAAGCAACAACAAGTACGCGGC GGTGTCGTGGAACTCAGGCGCCCTGACCAGCGG CAGCAGCTATCTGAGCCTGACGCCTGAGCAGTG CGTGCACACCTTCCCGGCTGTCCTACAGTCCTCA GAAGTCCCACAGAAGCTACAGCTGCCAGGTCAC GGACTCTACTCCCTCAGCAGCGTGGTGACCGTG GCATGAAGGGAGCACCGTGGAGAAGACAGTGG CCCTCCAGCAGCTTGGGCACCCAGACCTACATC CCCCTACAGAATGTTCA TGCAACGTGAATCACAAGCCCAGCAACACCAAG SEQ ID NO: 2020 GTGGACAAGAAAGTTGAGCCCAAATCTTGTGAC AAAACTCACACATGCCCACCGTGCCCAGCACCT GAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCC CCCCAAAACCCAAGGACACCCTCATGATCTCCC GGACCCCTGAGGTCACATGCGTGGTGGTGGACG TGAGCCACGAAGACCCTGAGGTCAAGTTCAACT GGTACGTGGACGGCGTGGAGGTGCATAATGCCA AGACAAAGCCGTGTGAGGAGCAGTACGGCAGC ACGTACCGTTGTGTCAGCGTCCTCACCGTCCTGC ACCAGGACTGGCTGAATGGCAAGGAGTACAAGT GCAAGGTCTCCAACAAAGCCCTCCCAGCCCCCA TCGAGAAAACCATCTCCAAAGCCAAAGGGCAGC CCCGAGAACCACAGGTGTACACCCTGCCCCCAT CCCGGGAGGAGATGACCAAGAACCAGGTCAGC CTGACCTGCCTGGTCAAAGGCTTCTATCCCAGC GACATCGCCGTGGAGTGGGAGAGCAATGGGCA GCCGGAGAACAACTACAAGACCACGCCTCCCGT GCTGGACTCCGACGGCTCCTTCTTCCTCTATAGC AAGCTCACCGTGGACAAGAGCAGGTGGCAGCA GGGGAACGTCTTCTCATGCTCCGTGATGCATGA GGCTCTGCACAACCACTACACGCAGAAGAGCCT CTCCCTGTCTCCGGGTAAA SEQ ID NO: 2177 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNYVNW QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ ASLAISGLQSEDEADYFCATFDSSLNAPVFGGGTK GRVTMTRDTSISTAYMELSSLRSDDTAVYYCARG LTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISD GDYVFGTYRPHYYYGMDVWGQGTTVTVSSASTK FYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKY GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV AASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSS APTECS SLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHT SEQ ID NO: 450 CPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTC VVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCEE QYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNKA LPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQV SLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVL DSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEAL HNHYTQKSLSLSPGK SEQ ID NO: 607 iPS:361485 2C2.005.014 NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGTAGCTCCAACATCGGAAGTCAAACTG AAGGCTTCCGGATACACCTTCACCGGCTACTAT TAAACTGGTACCAGCACCTCCCAGGAACGGCCC ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATCTATACTAATAATCAGCGGC CTTGAGTGGATGGGATGGATCAACCCTAACAGT CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GGTGGCACAAACTATGCACAGAAGTTTCAGGGC GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG AGGGTCACCATGACCAGGGACACGTCCATCAGT CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT CAACATTCGATGAAAGCCTGAGTGGTCCGGTAT GACGACACGGCCGTGTATTACTGTGCGAGAGGG TCGGCGGAGGGACCAAGCTGACCGTCCTAGGTC GGGGATTACGTTTTCGGGACTTATCGGCCTCACT AGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCC ACTACTACGGTATGGACGTCTGGGGCCAAGGGA GCCCTCCTCTGAGGAGCTTCAAGCCAACAAGGC CCACGGTCACCGTCTCCTCAGCCTCCACCAAGG CACACTGGTGTGTCTCATAAGTGACTTCTACCCG GCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAA GGAGCCGTGACAGTGGCCTGGAAGGCAGATAG GAGCACCTCTGGGGGCACAGCGGCCCTGGGCTG CAGCCCCGTCAAGGCGGGAGTGGAGACCACCAC CCTGGTCAAGGACTACTTCCCCGAACCGGTGAC ACCCTCCAAACAAAGCAACAACAAGTACGCGGC GGTGTCGTGGAACTCAGGCGCCCTGACCAGCGG CAGCAGCTATCTGAGCCTGACGCCTGAGCAGTG CGTGCACACCTTCCCGGCTGTCCTACAGTCCTCA GAAGTCCCACAGAAGCTACAGCTGCCAGGTCAC GGACTCTACTCCCTCAGCAGCGTGGTGACCGTG GCATGAAGGGAGCACCGTGGAGAAGACAGTGG CCCTCCAGCAGCTTGGGCACCCAGACCTACATC CCCCTACAGAATGTTCA TGCAACGTGAATCACAAGCCCAGCAACACCAAG SEQ ID NO: 2021 GTGGACAAGAAAGTTGAGCCCAAATCTTGTGAC AAAACTCACACATGCCCACCGTGCCCAGCACCT GAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCC CCCCAAAACCCAAGGACACCCTCATGATCTCCC GGACCCCTGAGGTCACATGCGTGGTGGTGGACG TGAGCCACGAAGACCCTGAGGTCAAGTTCAACT GGTACGTGGACGGCGTGGAGGTGCATAATGCCA AGACAAAGCCGTGTGAGGAGCAGTACGGCAGC ACGTACCGTTGTGTCAGCGTCCTCACCGTCCTGC ACCAGGACTGGCTGAATGGCAAGGAGTACAAGT GCAAGGTCTCCAACAAAGCCCTCCCAGCCCCCA TCGAGAAAACCATCTCCAAAGCCAAAGGGCAGC CCCGAGAACCACAGGTGTACACCCTGCCCCCAT CCCGGGAGGAGATGACCAAGAACCAGGTCAGC CTGACCTGCCTGGTCAAAGGCTTCTATCCCAGC GACATCGCCGTGGAGTGGGAGAGCAATGGGCA GCCGGAGAACAACTACAAGACCACGCCTCCCGT GCTGGACTCCGACGGCTCCTTCTTCCTCTATAGC AAGCTCACCGTGGACAAGAGCAGGTGGCAGCA GGGGAACGTCTTCTCATGCTCCGTGATGCATGA GGCTCTGCACAACCACTACACGCAGAAGAGCCT CTCCCTGTCTCCGGGTAAA SEQ ID NO: 2178 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSQTVNW QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY YQHLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ ASLAISGLQSEDEADYFCATFDESLSGPVFGGGTK GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG LTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISD GDYVFGTYRPHYYYGMDVWGQGTTVTVSSASTK FYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKY GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV AASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTV SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSS APTECS SLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHT SEQ ID NO: 451 CPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTC VVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCEE QYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNKA LPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQV SLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVL DSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEAL HNHYTQKSLSLSPGK SEQ ID NO: 608 iPS:361845 18F2.013 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACCTTAGAAATTATTTAG GCAGCGTCTGGATTCACTTTCAGTAACTTTGGCA GCTGGTATCAACAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCCCCAGGCAAGGGGC AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATGAAAACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GATTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCAA AGGACACGGCTGTGTATTACTGTGCGAGAGATA GGGACCAAAGTGGATATCAAACGAACGGTGGCT GGACGATCTTTGGAGTGGTCTTGGGGGACTACT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 2022 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2179 AA DIQMTQSPSSLSASIGDRVTITCRASQDLRNYLGW QVQLVESGGGVVQPGRSLRLSCAASGFTFSNFGM YQQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTE HWVRQAPGKGLEWVAVIWYDASNENYADAVKG FTLTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDI RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR TIFGVVLGDYWGQGTLVTVSSASTKGPSVFPLAPS EAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN RGEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 452 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV ASVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 609 iPS:361851 6H1.009 NA GACATCCAGATGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTATAGGAGACAGAGTCACCATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGGACATTAGAGATTATTTAG GCAGCGTCTGGATTCACCTTCAGTTACTTTGGCA GCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA TGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGC AGCGCCTGATCTATGGTGCATCCAGTTTGCAAA TGGAGTGGGTGGCAGTTATATGGTATGATGCAA GTGGGGTCCCTTCAAGGTTCAGCGGCAGTGGAT GTAATAAATACTATGCAGACGCCGTGAAGGGCC CTGGGACAGAATTCACTCTCACAATCAGCAGCC GCTTCACCATCTCCAGAGACAATTCCAAGAACA TGCAGCCTGAAGATTTCGCAACTTATTACTGTCT CGCTGTATCTGCAAATGAACAGCCTGAGAGCCG ACAGCATAATAATTACCCCTTCACTTTCGGCCAA AGGACACGGCTGTGTATTACTGTGCGCGAGATA GGGACCAAAGTGGATATCAAACGAACGGTGGCT GGACGATTTTTGGAGTGCTCTTGGGGGACTACT GCACCATCTGTCTTCATCTTCCCGCCATCTGATG GGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGT CCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGC GCCTGCTGAATAACTTCTATCCCAGAGAGGCCA ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGC AAGTACAGTGGAAGGTGGATAACGCCCTCCAAT GGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGG CGAACCGGTGACGGTGTCGTGGAACTCAGGCGC ACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCTGACCAGCGGCGTGCACACCTTCCCGGCTGT CCCTGACGCTGAGCAAAGCAGACTACGAGAAAC CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGC ACAAAGTCTACGCCTGCGAAGTCACCCATCAGG GTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC GCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA CAGACCTACATCTGCAACGTGAATCACAAGCCC GGGGAGAGTGT AGCAACACCAAGGTGGACAAGAAAGTTGAGCC SEQ ID NO: 2023 CAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAACTCCTGGGGGGACCGTC AGTCTTCCTCTTCCCCCCAAAACCCAAGGACAC CCTCATGATCTCCCGGACCCCTGAGGTCACATG CGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGTGTGAGGA GCAGTACGGCAGCACGTACCGTTGTGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGG CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGC CCTCCCAGCCCCCATCGAGAAAACCATCTCCAA AGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCATCCCGGGAGGAGATGACCA AGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG GCTTCTATCCCAGCGACATCGCCGTGGAGTGGG AGAGCAATGGGCAGCCGGAGAACAACTACAAG ACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAG AGCAGGTGGCAGCAGGGGAACGTCTTCTCATGC TCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2180 AA DIQMTQSPSSLSASIGDRVTITCRASQDIRDYLGWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSYFGM QQKPGKAPKRLIYGASSLQSGVPSRFSGSGSGTEFT HWVRQAPGKGLEWVAVIWYDASNKYYADAVKG LTISSLQPEDFATYYCLQHNNYPFTFGQGTKVDIK RFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDR RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE TIFGVLLGDYWGQGTLVTVSSASTKGPSVFPLAPS AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS TLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN GEC VNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELL SEQ ID NO: 453 GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPCEEQYGSTYRCV SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISK AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPGK SEQ ID NO: 610 iPS:361855 2C2.005.015 NA CAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTG CAGATGCAGGTGGTGCAGTCTGGGGCTGAGGTG GGACCCCCGGGCAGAGGGTCACCATCTCTTGTT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGTAGCTCCAACATCGGAAGTAATACTG AAGGCTTCCGGATACACCTTCACCGGCTACTAT TAAACTGGTACCAGCAACTCCCAGGAACGGCCC ATGCATTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATCTATACTAATAATCAGCGGC CTTGAGTGGATGGGATGGATCAACCCTAACAGT CCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAA GGTGGCACAAACTATGCACAGAAGTTTCAGGGC GTCTGGCACCTCAGCCTCCCTTGCCATCAGTGGG AGGGTCACCATGACCAGGGACACGTCCATCAGT CTCCAGTCTGAGGATGAGGCTGATTATTTCTGTG ACAGCCTACATGGAGCTGAGCAGGCTGAGGTCT CAACATTCGATAGCAGCCTGAGTGGTCCGGTAT GACGACACGGCCGTGTATTACTGTGCGAGAGGG TCGGCGGAGGGACCAAGCTGACCGTCCTAGGTC GGGGATTACGTTTGGGGGACTTATCGGCCTCAC AGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCC TACTACTACGGTATGGACGTCTGGGGCCAAGGG GCCCTCCTCTGAGGAGCTTCAAGCCAACAAGGC ACCACGGTCACCGTCTCCTCAGCCTCCACCAAG CACACTGGTGTGTCTCATAAGTGACTTCTACCCG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCA GGAGCCGTGACAGTGGCCTGGAAGGCAGATAG AGAGCACCTCTGGGGGCACAGCGGCCCTGGGCT CAGCCCCGTCAAGGCGGGAGTGGAGACCACCAC GCCTGGTCAAGGACTACTTCCCCGAACCGGTGA ACCCTCCAAACAAAGCAACAACAAGTACGCGGC CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCG CAGCAGCTATCTGAGCCTGACGCCTGAGCAGTG GCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC GAAGTCCCACAGAAGCTACAGCTGCCAGGTCAC AGGACTCTACTCCCTCAGCAGCGTGGTGACCGT GCATGAAGGGAGCACCGTGGAGAAGACAGTGG GCCCTCCAGCAGCTTGGGCACCCAGACCTACAT CCCCTACAGAATGTTCA CTGCAACGTGAATCACAAGCCCAGCAACACCAA SEQ ID NO: 2024 GGTGGACAAGAAAGTTGAGCCCAAATCTTGTGA CAAAACTCACACATGCCCACCGTGCCCAGCACC TGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTC CCCCCAAAACCCAAGGACACCCTCATGATCTCC CGGACCCCTGAGGTCACATGCGTGGTGGTGGAC GTGAGCCACGAAGACCCTGAGGTCAAGTTCAAC TGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGTGTGAGGAGCAGTACGGCAG CACGTACCGTTGTGTCAGCGTCCTCACCGTCCTG CACCAGGACTGGCTGAATGGCAAGGAGTACAA GTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACCACAGGTGTACACCCTGCCCCC ATCCCGGGAGGAGATGACCAAGAACCAGGTCA AGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCA GCGACATCGCCGTGGAGTGGGAGAGCAATGGG CAGCCGGAGAACAACTACAAGACCACGCCTCCC GTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAG CAGGGGAACGTCTTCTCATGCTCCGTGATGCAT NGAGGCTCTGCACAACCACTACACGCAGAAGAGC CTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2181 AA QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNTVNW QMQVVQSGAEVKKPGASVKVSCKASGYTFTGYY YQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTS MHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQ ASLAISGLQSEDEADYFCATFDSSLSGPVFGGGTK GRVTMTRDTSISTAYMELSRLRSDDTAVYYCARG LTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISD GDYVWGTYRPHYYYGMDVWGQGTTVTVSSAST FYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKY KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT AASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTV VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS APTECS SSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH SEQ ID NO: 454 TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO: 611 iPS:336067 5G12.006 NA GACATCCAGCTGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACTATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGACCATTAGCAGGTTTTTAA ACAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCTGGGAAAGCCCCTG ATACACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTATGTTGCATCCAGTTTGCAAAG CTGGAGTGGGTGGCAGTTATATGGTATGATGGA TGGGGTCCCATCAAGATTCAGTGGCAGTGGTTC AGTAATAAGTTCCATGCAGACTCCGTGAAGGGC TGGGACAGATTTCACTCTCACCATCAGCAGTCT CGATTCACCATCTCCAGAGACAATTCCAAGAAC GCAACCTGAAGATTTTGCAACTTACTACTGTCA ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC ACAGAGTTACAGTACCCTGATCAGTTTTGGCCA GAGGACTCGGCTATGTACTTCTGTGCGAGAGGA GGGGACCAAGCTGGAGATCACACGAACGGTGG AAAGTGGCTGGTATGCCTGAAGCTTTTGAAATC CTGCACCATCTGTCTTCATCTTCCCGCCATCTGA TGGGGCCAAGGGACAAAGGTCACCGTCTCTTCA TGAGCAGTTGAAATCTGGAACTGCCTCTGTTGT GCCTCCACCAAGGGCCCATCGGTCTTCCCCCTG GTGCCTGCTGAATAACTTCTATCCCAGAGAGGC GCACCCTCCTCCAAGAGCACCTCTGGGGGCACA CAAAGTACAGTGGAAGGTGGATAACGCCCTCCA GCGGCCCTGGGCTGCCTGGTCAAGGACTACTTC ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCA CCCGAACCGGTGACGGTGTCGTGGAACTCAGGC GGACAGCAAGGACAGCACCTACAGCCTCAGCA GCCCTGACCAGCGGCGTGCACACCTTCCCGGCT GCACCCTGACGCTGAGCAAAGCAGACTACGAGA GTCCTACAGTCCTCAGGACTCTACTCCCTCAGCA AACACAAAGTCTACGCCTGCGAAGTCACCCATC GCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCA AGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCA CCCAGACCTACATCTGCAACGTGAATCACAAGC ACAGGGGAGAGTGT CCAGCAACACCAAGGTGGACAAGAAAGTTGAG SEQ ID NO: 2025 CCCAAATCTTGTGACAAAACTCACACATGCCCA CCGTGCCCAGCACCTGAACTCCTGGGGGGACCG TCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACA CCCTCATGATCTCCCGGACCCCTGAGGTCACAT GCGTGGTGGTGGACGTGAGCCACGAAGACCCTG AGGTCAAGTTCAACTGGTACGTGGACGGCGTGG AGGTGCATAATGCCAAGACAAAGCCGTGTGAGG AGCAGTACGGCAGCACGTACCGTTGTGTCAGCG TCCTCACCGTCCTGCACCAGGACTGGCTGAATG GCAAGGAGTACAAGTGCAAGGTCTCCAACAAA GCCCTCCCAGCCCCCATCGAGAAAACCATCTCC AAAGCCAAAGGGCAGCCCCGAGAACCACAGGT GTACACCCTGCCCCCATCCCGGGAGGAGATGAC CAAGAACCAGGTCAGCCTGACCTGCCTGGTCAA AGGCTTCTATCCCAGCGACATCGCCGTGGAGTG GGAGAGCAATGGGCAGCCGGAGAACAACTACA AGACCACGCCTCCCGTGCTGGACTCCGACGGCT CCTTCTTCCTCTATAGCAAGCTCACCGTGGACAA GAGCAGGTGGCAGCAGGGGAACGTCTTCTCATG CTCCGTGATGCATGAGGCTCTGCACAACCACTA CACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAA A SEQ ID NO: 2182 AA DIQLTQSPSSLSASVGDRVTITCRASQTISRFLNWY QVQLVESGGGVVQPGRSLRLSCTASGFTFSSYGIH QQKPGKAPELLIYVASSLQSGVPSRFSGSGSGTDFT WVRQAPGKGLEWVAVIWYDGSNKFHADSVKGRF LTISSLQPEDFATYYCQQSYSTLISFGQGTKLEITR TISRDNSKNTLYLQMNSLRAEDSAMYFCARGKVA TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA GMPEAFEIWGQGTKVTVSSASTKGSVFPLAPSSK PKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSST STSGGTAALGCLVKDYFPEPVTVSWNSGALTSGV LTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG HTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVN EC HKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGP SEQ ID NO: 455 SVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEV KFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSVL TVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAK GQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPS DIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKL TVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSL SPGK SEQ ID NO: 612 iPS:336169 17B11.002 NA CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGCAGCTCCAACATTGGAAATAATTATG AAGGCTTCTGGATACACCTTCACCAGTTATGAT TATCCTGGTATGAGCAGTTCCCAGGAACAGCCC ATCAACTGGGTGCGACAGGCCACTGGACAAGGG CCAAACTCCTCATTTATGACAATAATAAGCGAC CTTGAGTGGATGGGATGGATGAACCCTAACAGT CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GGTAACACAGGCTATGCACAGAAGTTCCAGGGC GTCTGGCACGTCAGCCACCCTGGGCATCACCGG AGAGTCACCATGACCAGGGACACCTCCATAAGC ACTCCAGACTGGGGACGAGGCCGATTATTACTG ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT CGGAACATGGGATAGCAGCCTGAGTGCTGTGGT CAGGACACGGCCGTGTATTACTGTGCGAGAGGG ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG GGTGATTACGTTTGGGGGAGTTATCGTCCCTACT TCAGCCCAAGGCTGCCCCCTCGGTCACTCTGTTC ACTACTACTACGGTATGGACGTCTGGGGCCAAG CCGCCCTCCTCTGAGGAGCTTCAAGCCAACAAG GGACCACGGTCACCGTCTCCTCAGCCTCCACCA GCCACACTGGTGTGTCTCATAAGTGACTTCTACC AGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTC CGGGAGCCGTGACAGTGGCCTGGAAGGCAGAT CAAGAGCACCTCTGGGGGCACAGCGGCCCTGGG AGCAGCCCCGTCAAGGCGGGAGTGGAGACCAC CTGCCTGGTCAAGGACTACTTCCCCGAACCGGT CACACCCTCCAAACAAAGCAACAACAAGTACGC GACGGTGTCGTGGAACTCAGGCGCCCTGACCAG GGCCAGCAGCTATCTGAGCCTGACGCCTGAGCA CGGCGTGCACACCTTCCCGGCTGTCCTACAGTCC GTGGAAGTCCCACAGAAGCTACAGCTGCCAGGT TCAGGACTCTACTCCCTCAGCAGCGTGGTGACC CACGCATGAAGGGAGCACCGTGGAGAAGACAG GTGCCCTCCAGCAGCTTGGGCACCCAGACCTAC TGGCCCCTACAGAATGTTCA ATCTGCAACGTGAATCACAAGCCCAGCAACACC SEQ ID NO: 2026 AAGGTGGACAAGAAAGTTGAGCCCAAATCTTGT GACAAAACTCACACATGCCCACCGTGCCCAGCA CCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCT TCCCCCCAAAACCCAAGGACACCCTCATGATCT CCCGGACCCCTGAGGTCACATGCGTGGTGGTGG ACGTGAGCCACGAAGACCCTGAGGTCAAGTTCA ACTGGTACGTGGACGGCGTGGAGGTGCATAATG CCAAGACAAAGCCGTGTGAGGAGCAGTACGGC AGCACGTACCGTTGTGTCAGCGTCCTCACCGTCC TGCACCAGGACTGGCTGAATGGCAAGGAGTACA AGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCC CCATCGAGAAAACCATCTCCAAAGCCAAAGGGC AGCCCCGAGAACCACAGGTGTACACCCTGCCCC CATCCCGGGAGGAGATGACCAAGAACCAGGTC AGCCTGACCTGCCTGGTCAAAGGCTTCTATCCC AGCGACATCGCCGTGGAGTGGGAGAGCAATGG GCAGCCGGAGAACAACTACAAGACCACGCCTCC CGTGCTGGACTCCGACGGCTCCTTCTTCCTCTAT AGCAAGCTCACCGTGGACAAGAGCAGGTGGCA GCAGGGGAACGTCTTCTCATGCTCCGTGATGCA TGAGGCTCTGCACAACCACTACACGCAGAAGAG CCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2183 AA QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS QMQLVQSGAEVKKPGASVKVSCKASGYTFTSYDI WYEQFPGTAPKLLIYDNNKRPSGIPDRFSGSKSGTS NWVRQATGQGLEWMGWMNPNSGNTGYAQKFQ ATLGITGLQTGDEADYYCGTWDSSLSAVVFGGGT GRVTMTRDTSISTAYMELSSLRSQDTAVYYCARG KLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLIS GDYVWGSYRPYYYYYGMDVWGQGTTVTVSSAS DFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNK TKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPV YAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKT TVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVP VAPTECS SSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH SEQ ID NO: 456 TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO: 613 iPS:361127 5G12.006.001 NA GACATCCAGCTGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACTATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGACCATTAGCAGGTTTTTAA GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCTGGGAAAGCCCCTG ATACACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTATGTTGCATCCAGTTTGCAAAG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA TGGGGTCCCATCAAGATTCAGTGGCAGTGGTTC AGTAATAAGTTCCATGCAGACGCCGTGAAGGGC TGGGACAGATTTCACTCTCACCATCAGCAGTCT CGATTCACCATCTCCAGAGACAATTCCAAGAAC GCAACCTGAAGATTTTGCAACTTACTACTGTCA ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC ACAGAGTTACAGTACCCTGATCAGTTTTGGCCA GAGGACTCGGCTATGTACTTCTGTGCGAGAGGA GGGGACCAAGCTGGAGATCAAACGAACGGTGG AAAGTGGCTGGTATGCCTGAAGCTTTTGAAATC CTGCACCATCTGTCTTCATCTTCCCGCCATCTGA TGGGGCCAAGGGACAAAGGTCACCGTCTCTTCA TGAGCAGTTGAAATCTGGAACTGCCTCTGTTGT GCCTCCACCAAGGGCCCATCGGTCTTCCCCCTG GTGCCTGCTGAATAACTTCTATCCCAGAGAGGC GCACCCTCCTCCAAGAGCACCTCTGGGGGCACA CAAAGTACAGTGGAAGGTGGATAACGCCCTCCA GCGGCCCTGGGCTGCCTGGTCAAGGACTACTTC ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCA CCCGAACCGGTGACGGTGTCGTGGAACTCAGGC GGACAGCAAGGACAGCACCTACAGCCTCAGCA GCCCTGACCAGCGGCGTGCACACCTTCCCGGCT GCACCCTGACGCTGAGCAAAGCAGACTACGAGA GTCCTACAGTCCTCAGGACTCTACTCCCTCAGCA AACACAAAGTCTACGCCTGCGAAGTCACCCATC GCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCA AGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCA CCCAGACCTACATCTGCAACGTGAATCACAAGC ACAGGGGAGAGTGT CCAGCAACACCAAGGTGGACAAGAAAGTTGAG SEQ ID NO: 2027 CCCAAATCTTGTGACAAAACTCACACATGCCCA CCGTGCCCAGCACCTGAACTCCTGGGGGGACCG TCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACA CCCTCATGATCTCCCGGACCCCTGAGGTCACAT GCGTGGTGGTGGACGTGAGCCACGAAGACCCTG AGGTCAAGTTCAACTGGTACGTGGACGGCGTGG AGGTGCATAATGCCAAGACAAAGCCGTGTGAGG AGCAGTACGGCAGCACGTACCGTTGTGTCAGCG TCCTCACCGTCCTGCACCAGGACTGGCTGAATG GCAAGGAGTACAAGTGCAAGGTCTCCAACAAA GCCCTCCCAGCCCCCATCGAGAAAACCATCTCC AAAGCCAAAGGGCAGCCCCGAGAACCACAGGT GTACACCCTGCCCCCATCCCGGGAGGAGATGAC CAAGAACCAGGTCAGCCTGACCTGCCTGGTCAA AGGCTTCTATCCCAGCGACATCGCCGTGGAGTG GGAGAGCAATGGGCAGCCGGAGAACAACTACA AGACCACGCCTCCCGTGCTGGACTCCGACGGCT CCTTCTTCCTCTATAGCAAGCTCACCGTGGACAA GAGCAGGTGGCAGCAGGGGAACGTCTTCTCATG CTCCGTGATGCATGAGGCTCTGCACAACCACTA CACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAA A SEQ ID NO: 2184 AA DIQLTQSPSSLSASVGDRVTITCRASQTISRFLNWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGIH QQKPGKAPELLIYVASSLQSGVPSRFSGSGSGTDFT WVRQAPGKGLEWVAVIWYDASNKFHADAVKGR LTISSLQPEDFATYYCQQSYSTLISFGQGTKLEIKR FTISRDNSKNTLYLQMNSLRAEDSAMYFCARGKV TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA AGMPEAFEIWGQGTKVTVSSASTKGPSVFPLAPSS KVQWKVDNALQSGNSQESVTEQDSKDSTYSLSST KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG LTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV EC NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG SEQ ID NO: 457 GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 614 iPS:361136 5G12.006.002 NA GACATCCAGCTGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACTATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGACCATTAGCAGGTTTTTAA ACAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCTGGGAAAGCCCCTG ATACACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTATGTTGCATCCAGTTTGCAAAG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA TGGGGTCCCATCAAGATTCAGTGGCAGTGGTTC AGTAATAAGTTCCATGCAGACGCCGTGAAGGGC TGGGACAGATTTCACTCTCACCATCAGCAGTCT CGATTCACCATCTCCAGAGACAATTCCAAGAAC GCAACCTGAAGATTTTGCAACTTACTACTGTCA ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC ACAGAGTTACAGTACCCTGATCAGTTTTGGCCA GAGGACTCGGCTATGTACTTCTGTGCGAGAGGA GGGGACCAAGCTGGAGATCAAACGAACGGTGG AAAGTGGCTGGTATGCCTGAAGCTTTTGAAATC CTGCACCATCTGTCTTCATCTTCCCGCCATCTGA TGGGGCCAAGGGACAAAGGTCACCGTCTCTTCA TGAGCAGTTGAAATCTGGAACTGCCTCTGTTGT GCCTCCACCAAGGGCCCATCGGTCTTCCCCCTG GTGCCTGCTGAATAACTTCTATCCCAGAGAGGC GCACCCTCCTCCAAGAGCACCTCTGGGGGCACA CAAAGTACAGTGGAAGGTGGATAACGCCCTCCA GCGGCCCTGGGCTGCCTGGTCAAGGACTACTTC ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCA CCCGAACCGGTGACGGTGTCGTGGAACTCAGGC GGACAGCAAGGACAGCACCTACAGCCTCAGCA GCCCTGACCAGCGGCGTGCACACCTTCCCGGCT GCACCCTGACGCTGAGCAAAGCAGACTACGAGA GTCCTACAGTCCTCAGGACTCTACTCCCTCAGCA AACACAAAGTCTACGCCTGCGAAGTCACCCATC GCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCA AGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCA CCCAGACCTACATCTGCAACGTGAATCACAAGC ACAGGGGAGAGTGT CCAGCAACACCAAGGTGGACAAGAAAGTTGAG SEQ ID NO: 2028 CCCAAATCTTGTGACAAAACTCACACATGCCCA CCGTGCCCAGCACCTGAACTCCTGGGGGGACCG TCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACA CCCTCATGATCTCCCGGACCCCTGAGGTCACAT GCGTGGTGGTGGACGTGAGCCACGAAGACCCTG AGGTCAAGTTCAACTGGTACGTGGACGGCGTGG AGGTGCATAATGCCAAGACAAAGCCGTGTGAGG AGCAGTACGGCAGCACGTACCGTTGTGTCAGCG TCCTCACCGTCCTGCACCAGGACTGGCTGAATG GCAAGGAGTACAAGTGCAAGGTCTCCAACAAA GCCCTCCCAGCCCCCATCGAGAAAACCATCTCC AAAGCCAAAGGGCAGCCCCGAGAACCACAGGT GTACACCCTGCCCCCATCCCGGGAGGAGATGAC CAAGAACCAGGTCAGCCTGACCTGCCTGGTCAA AGGCTTCTATCCCAGCGACATCGCCGTGGAGTG GGAGAGCAATGGGCAGCCGGAGAACAACTACA AGACCACGCCTCCCGTGCTGGACTCCGACGGCT CCTTCTTCCTCTATAGCAAGCTCACCGTGGACAA GAGCAGGTGGCAGCAGGGGAACGTCTTCTCATG CTCCGTGATGCATGAGGCTCTGCACAACCACTA CACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAA A SEQ ID NO: 2185 AA DIQLTQSPSSLSASVGDRVTITCRASQTISRFLNWY QVQLVESGGGVVQPGRSLRLSCTASGFTFSSYGIH QQKPGKAPELLIYVASSLQSGVPSRFSGSGSGTDFT WVRQAPGKGLEWVAVIWYDASNKFHADAVKGR LTISSLQPEDFATYYCQQSYSTLISFGQGTKLEIKR FTISRDNSKNTLYLQMNSLRAEDSAMYFCARGKV TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA AGMPEAFEIWGQGTKVTVSSASTKGPSVFPLAPSS KVQWKVDNALQSGNSQESVTEQDSKDSTYSLSST KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG LTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV EC NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG SEQ ID NO: 458 GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 615 iPS:361140 5G12.006.003 NA GACATCCAGCTGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACTATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGACCATTAGCAGGTTTTTAA GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCTGGGAAAGCCCCTG ATACACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTATGTTGCATCCAGTTTGCAAAG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA TGGGGTCCCATCAAGATTCAGTGGCAGTGGTTC AGTAATAAGTTCCATGCAGACGCCGTGAAGGGC TGGGACAGATTTCACTCTCACCATCAGCAGTCT CGATTCACCATCTCCAGAGACAATTCCAAGAAC GCAACCTGAAGATTTTGCAACTTACTACTGTCA ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC ACAGAGTTACAGTACCCTGATCAGTTTTGGCCA GAGGACTCGGCTATGTACTTCTGTGCGAGAGGA GGGGACCAAGCTGGAGATCACACGAACGGTGG AAAGTGGCTGGTATGCCTGAAGCTTTTGAAATC CTGCACCATCTGTCTTCATCTTCCCGCCATCTGA TGGGGCCAAGGGACAAAGGTCACCGTCTCTTCA TGAGCAGTTGAAATCTGGAACTGCCTCTGTTGT GCCTCCACCAAGGGCCCATCGGTCTTCCCCCTG GTGCCTGCTGAATAACTTCTATCCCAGAGAGGC GCACCCTCCTCCAAGAGCACCTCTGGGGGCACA CAAAGTACAGTGGAAGGTGGATAACGCCCTCCA GCGGCCCTGGGCTGCCTGGTCAAGGACTACTTC ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCA CCCGAACCGGTGACGGTGTCGTGGAACTCAGGC GGACAGCAAGGACAGCACCTACAGCCTCAGCA GCCCTGACCAGCGGCGTGCACACCTTCCCGGCT GCACCCTGACGCTGAGCAAAGCAGACTACGAGA GTCCTACAGTCCTCAGGACTCTACTCCCTCAGCA AACACAAAGTCTACGCCTGCGAAGTCACCCATC GCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCA AGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCA CCCAGACCTACATCTGCAACGTGAATCACAAGC ACAGGGGAGAGTGT CCAGCAACACCAAGGTGGACAAGAAAGTTGAG SEQ ID NO: 2029 CCCAAATCTTGTGACAAAACTCACACATGCCCA CCGTGCCCAGCACCTGAACTCCTGGGGGGACCG TCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACA CCCTCATGATCTCCCGGACCCCTGAGGTCACAT GCGTGGTGGTGGACGTGAGCCACGAAGACCCTG AGGTCAAGTTCAACTGGTACGTGGACGGCGTGG AGGTGCATAATGCCAAGACAAAGCCGTGTGAGG AGCAGTACGGCAGCACGTACCGTTGTGTCAGCG TCCTCACCGTCCTGCACCAGGACTGGCTGAATG GCAAGGAGTACAAGTGCAAGGTCTCCAACAAA GCCCTCCCAGCCCCCATCGAGAAAACCATCTCC AAAGCCAAAGGGCAGCCCCGAGAACCACAGGT GTACACCCTGCCCCCATCCCGGGAGGAGATGAC CAAGAACCAGGTCAGCCTGACCTGCCTGGTCAA AGGCTTCTATCCCAGCGACATCGCCGTGGAGTG GGAGAGCAATGGGCAGCCGGAGAACAACTACA AGACCACGCCTCCCGTGCTGGACTCCGACGGCT CCTTCTTCCTCTATAGCAAGCTCACCGTGGACAA GAGCAGGTGGCAGCAGGGGAACGTCTTCTCATG CTCCGTGATGCATGAGGCTCTGCACAACCACTA CACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAA A SEQ ID NO: 2186 AA DIQLTQSPSSLSASVGDRVTITCRASQTISRFLNWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGIH QQKPGKAPELLIYVASSLQSGVPSRFSGSGSGTDFT WVRQAPGKGLEWVAVIWYDASNKFHADAVKGR LTISSLQPEDFATYYCQQSYSTLISFGQGTKLEITR FTISRDNSKNTLYLQMNSLRAEDSAMYFCARGKV TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA AGMPEAFEIWGQGTKVTVSSASTKGPSVFPLAPSS KVQWKVDNALQSGNSQESVTEQDSKDSTYSLSST KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG LTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV EC NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG SEQ ID NO: 459 GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 616 iPS:359919 5G12.006.004 NA GACATCCAGCTGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACTATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGACCATTAGCAGGTTTTTAA GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCTGGGAAAGCCCCTA ATACACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTATGTTGCATCCAGTTTGCAAAG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA TGGGGTCCCATCAAGATTCAGTGGCAGTGGTTC AGTAATAAGTTCCATGCAGACGCCGTGAAGGGC TGGGACAGATTTCACTCTCACCATCAGCAGTCT CGATTCACCATCTCCAGAGACAATTCCAAGAAC GCAACCTGAAGATTTTGCAACTTACTACTGTCA ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC ACAGAGTTACAGTACCCTGATCAGTTTTGGCCA GAGGACTCGGCTATGTACTTCTGTGCGAGAGGA GGGGACCAAGCTGGAGATCAAACGAACGGTGG AAAGTGGCTGGTATGCCTGAAGCTTTTGAAATC CTGCACCATCTGTCTTCATCTTCCCGCCATCTGA TGGGGCCAAGGGACATTGGTCACCGTCTCTTCA TGAGCAGTTGAAATCTGGAACTGCCTCTGTTGT GCCTCCACCAAGGGCCCATCGGTCTTCCCCCTG GTGCCTGCTGAATAACTTCTATCCCAGAGAGGC GCACCCTCCTCCAAGAGCACCTCTGGGGGCACA CAAAGTACAGTGGAAGGTGGATAACGCCCTCCA GCGGCCCTGGGCTGCCTGGTCAAGGACTACTTC ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCA CCCGAACCGGTGACGGTGTCGTGGAACTCAGGC GGACAGCAAGGACAGCACCTACAGCCTCAGCA GCCCTGACCAGCGGCGTGCACACCTTCCCGGCT GCACCCTGACGCTGAGCAAAGCAGACTACGAGA GTCCTACAGTCCTCAGGACTCTACTCCCTCAGCA AACACAAAGTCTACGCCTGCGAAGTCACCCATC GCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCA AGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCA CCCAGACCTACATCTGCAACGTGAATCACAAGC ACAGGGGAGAGTGT CCAGCAACACCAAGGTGGACAAGAAAGTTGAG SEQ ID NO: 2030 CCCAAATCTTGTGACAAAACTCACACATGCCCA CCGTGCCCAGCACCTGAACTCCTGGGGGGACCG TCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACA CCCTCATGATCTCCCGGACCCCTGAGGTCACAT GCGTGGTGGTGGACGTGAGCCACGAAGACCCTG AGGTCAAGTTCAACTGGTACGTGGACGGCGTGG AGGTGCATAATGCCAAGACAAAGCCGTGTGAGG AGCAGTACGGCAGCACGTACCGTTGTGTCAGCG TCCTCACCGTCCTGCACCAGGACTGGCTGAATG GCAAGGAGTACAAGTGCAAGGTCTCCAACAAA GCCCTCCCAGCCCCCATCGAGAAAACCATCTCC AAAGCCAAAGGGCAGCCCCGAGAACCACAGGT GTACACCCTGCCCCCATCCCGGGAGGAGATGAC CAAGAACCAGGTCAGCCTGACCTGCCTGGTCAA AGGCTTCTATCCCAGCGACATCGCCGTGGAGTG GGAGAGCAATGGGCAGCCGGAGAACAACTACA AGACCACGCCTCCCGTGCTGGACTCCGACGGCT CCTTCTTCCTCTATAGCAAGCTCACCGTGGACAA GAGCAGGTGGCAGCAGGGGAACGTCTTCTCATG CTCCGTGATGCATGAGGCTCTGCACAACCACTA CACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAA A SEQ ID NO: 2187 AA DIQLTQSPSSLSASVGDRVTITCRASQTISRFLNWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGIH QQKPGKAPKLLIYVASSLQSGVPSRFSGSGSGTDF WVRQAPGKGLEWVAVIWYDASNKFHADAVKGR TLTISSLQPEDFATYYCQQSYSTLISFGQGTKLEIK FTISRDNSKNTLYLQMNSLRAEDSAMYFCARGKV RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE AGMPEAFEIWGQGTLVTVSSASTKGPSVFPLAPSS AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSST KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG LTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV EC NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG SEQ ID NO: 460 GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 617 iPS:361144 5G12.006.005 NA GACATCCAGCTGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACTATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGACCATTAGCAGGTTTTTAA GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCTGGGAAAGCCCCTG ATACACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTATGTTGCATCCAGTTTGCAAAG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA TGGGGTCCCATCAAGATTCAGTGGCAGTGGTTC AGTAATAAGTTCCATGCAGACTCCGTGAAGGGC TGGGACAGATTTCACTCTCACCATCAGCAGTCT CGATTCACCATCTCCAGAGACAATTCCAAGAAC GCAACCTGAAGATTTTGCAACTTACTACTGTCA ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC ACAGAGTTACAGTACCCTGATCAGTTTTGGCCA GAGGACTCGGCTATGTACTTCTGTGCGAGAGGA GGGGACCAAGCTGGAGATCAAACGAACGGTGG AAAGTGGCTGGTATGCCTGAAGCTTTTGAAATC CTGCACCATCTGTCTTCATCTTCCCGCCATCTGA TGGGGCCAAGGGACAAAGGTCACCGTCTCTTCA TGAGCAGTTGAAATCTGGAACTGCCTCTGTTGT GCCTCCACCAAGGGCCCATCGGTCTTCCCCCTG GTGCCTGCTGAATAACTTCTATCCCAGAGAGGC GCACCCTCCTCCAAGAGCACCTCTGGGGGCACA CAAAGTACAGTGGAAGGTGGATAACGCCCTCCA GCGGCCCTGGGCTGCCTGGTCAAGGACTACTTC ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCA CCCGAACCGGTGACGGTGTCGTGGAACTCAGGC GGACAGCAAGGACAGCACCTACAGCCTCAGCA GCCCTGACCAGCGGCGTGCACACCTTCCCGGCT GCACCCTGACGCTGAGCAAAGCAGACTACGAGA GTCCTACAGTCCTCAGGACTCTACTCCCTCAGCA AACACAAAGTCTACGCCTGCGAAGTCACCCATC GCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCA AGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCA CCCAGACCTACATCTGCAACGTGAATCACAAGC ACAGGGGAGAGTGT CCAGCAACACCAAGGTGGACAAGAAAGTTGAG SEQ ID NO: 2031 CCCAAATCTTGTGACAAAACTCACACATGCCCA CCGTGCCCAGCACCTGAACTCCTGGGGGGACCG TCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACA CCCTCATGATCTCCCGGACCCCTGAGGTCACAT GCGTGGTGGTGGACGTGAGCCACGAAGACCCTG AGGTCAAGTTCAACTGGTACGTGGACGGCGTGG AGGTGCATAATGCCAAGACAAAGCCGTGTGAGG AGCAGTACGGCAGCACGTACCGTTGTGTCAGCG TCCTCACCGTCCTGCACCAGGACTGGCTGAATG GCAAGGAGTACAAGTGCAAGGTCTCCAACAAA GCCCTCCCAGCCCCCATCGAGAAAACCATCTCC AAAGCCAAAGGGCAGCCCCGAGAACCACAGGT GTACACCCTGCCCCCATCCCGGGAGGAGATGAC CAAGAACCAGGTCAGCCTGACCTGCCTGGTCAA AGGCTTCTATCCCAGCGACATCGCCGTGGAGTG GGAGAGCAATGGGCAGCCGGAGAACAACTACA AGACCACGCCTCCCGTGCTGGACTCCGACGGCT CCTTCTTCCTCTATAGCAAGCTCACCGTGGACAA GAGCAGGTGGCAGCAGGGGAACGTCTTCTCATG CTCCGTGATGCATGAGGCTCTGCACAACCACTA CACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAA A SEQ ID NO: 2188 AA DIQLTQSPSSLSASVGDRVTITCRASQTISRFLNWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGIH QQKPGKAPELLIYVASSLQSGVPSRFSGSGSGTDFT WVRQAPGKGLEWVAVIWYDASNKFHADSVKGRF LTISSLQPEDFATYYCQQSYSTLISFGQGTKLEIKR TISRDNSKNTLYLQMNSLRAEDSAMYFCARGKVA TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA GMPEAFEIWGQGTKVTVSSASTKGPSVFPLAPSSK KVQWKVDNALQSGNSQESVTEQDSKDSTYSLSST STSGGTAALGCLVKDYFPEPVTVSWNSGALTSGV LTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG HTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVN EC HKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGP SEQ ID NO: 461 SVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEV KFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSVL TVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAK GQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPS DIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKL TVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSL SPGK SEQ ID NO: 618 iPS:361151 5G12.006.006 NA GACATCCAGCTGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACTATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGACCATTAGCAGGTTTTTAA GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCTGGGAAAGCCCCTG ATACACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTATGTTGCATCCAGTTTGCAAAG CTGGAGTGGGTGGCAGTTATATGGTATGATGGA TGGGGTCCCATCAAGATTCAGTGGCAGTGGTTC AGTAATAAGTTCCATGCAGACGCCGTGAAGGGC TGGGACAGATTTCACTCTCACCATCAGCAGTCT CGATTCACCATCTCCAGAGACAATTCCAAGAAC GCAACCTGAAGATTTTGCAACTTACTACTGTCA ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC ACAGAGTTACAGTACCCTGATCAGTTTTGGCCA GAGGACTCGGCTATGTACTTCTGTGCGAGAGGA GGGGACCAAGCTGGAGATCAAACGAACGGTGG AAAGTGGCTGGTATGCCTGAAGCTTTTGAAATC CTGCACCATCTGTCTTCATCTTCCCGCCATCTGA TGGGGCCAAGGGACAAAGGTCACCGTCTCTTCA TGAGCAGTTGAAATCTGGAACTGCCTCTGTTGT GCCTCCACCAAGGGCCCATCGGTCTTCCCCCTG GTGCCTGCTGAATAACTTCTATCCCAGAGAGGC GCACCCTCCTCCAAGAGCACCTCTGGGGGCACA CAAAGTACAGTGGAAGGTGGATAACGCCCTCCA GCGGCCCTGGGCTGCCTGGTCAAGGACTACTTC ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCA CCCGAACCGGTGACGGTGTCGTGGAACTCAGGC GGACAGCAAGGACAGCACCTACAGCCTCAGCA GCCCTGACCAGCGGCGTGCACACCTTCCCGGCT GCACCCTGACGCTGAGCAAAGCAGACTACGAGA GTCCTACAGTCCTCAGGACTCTACTCCCTCAGCA AACACAAAGTCTACGCCTGCGAAGTCACCCATC GCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCA AGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCA CCCAGACCTACATCTGCAACGTGAATCACAAGC ACAGGGGAGAGTGT CCAGCAACACCAAGGTGGACAAGAAAGTTGAG SEQ ID NO: 2032 CCCAAATCTTGTGACAAAACTCACACATGCCCA CCGTGCCCAGCACCTGAACTCCTGGGGGGACCG TCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACA CCCTCATGATCTCCCGGACCCCTGAGGTCACAT GCGTGGTGGTGGACGTGAGCCACGAAGACCCTG AGGTCAAGTTCAACTGGTACGTGGACGGCGTGG AGGTGCATAATGCCAAGACAAAGCCGTGTGAGG AGCAGTACGGCAGCACGTACCGTTGTGTCAGCG TCCTCACCGTCCTGCACCAGGACTGGCTGAATG GCAAGGAGTACAAGTGCAAGGTCTCCAACAAA GCCCTCCCAGCCCCCATCGAGAAAACCATCTCC AAAGCCAAAGGGCAGCCCCGAGAACCACAGGT GTACACCCTGCCCCCATCCCGGGAGGAGATGAC CAAGAACCAGGTCAGCCTGACCTGCCTGGTCAA AGGCTTCTATCCCAGCGACATCGCCGTGGAGTG GGAGAGCAATGGGCAGCCGGAGAACAACTACA AGACCACGCCTCCCGTGCTGGACTCCGACGGCT CCTTCTTCCTCTATAGCAAGCTCACCGTGGACAA GAGCAGGTGGCAGCAGGGGAACGTCTTCTCATG CTCCGTGATGCATGAGGCTCTGCACAACCACTA CACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAA A SEQ ID NO: 2189 AA DIQLTQSPSSLSASVGDRVTITCRASQTISRFLNWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGIH QQKPGKAPELLIYVASSLQSGVPSRFSGSGSGTDFT WVRQAPGKGLEWVAVIWYDGSNKFHADAVKGR LTISSLQPEDFATYYCQQSYSTLISFGQGTKLEIKR FTISRDNSKNTLYLQMNSLRAEDSAMYFCARGKV TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA AGMPEAFEIWGQGTKVTVSSASTKGPSVFPLAPSS KVQWKVDNALQSGNSQESVTEQDSKDSTYSLSST KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG LTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV EC NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG SEQ ID NO: 462 GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 619 iPS:361491 17B11.002.001 NA CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGCAGCTCCAACATTGGAAATAATTATG AAGGCTTCTGGATACACCTTCACCAGTTATGAT TATCCTGGTATCAGCAGCTCCCAGGAACAGCCC ATCAACTGGGTGCGACAGGCCACTGGACAAGGG CCAAACTCCTCATTTATGACAATAATAAGCGAC CTTGAGTGGATGGGATGGATGAACCCTAACAGT CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GGTGGCACAGGCTATGCACAGAAGTTCCAGGGC GTCTGGCACGTCAGCCACCCTGGGCATCACCGG AGAGTCACCATGACCAGGGACACCTCCATAAGC ACTCCAGACTGGGGACGAGGCCGATTATTACTG ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT CGGAACATGGGATAGCAGCCTGAGTGCTGTGGT CAGGACACGGCCGTGTATTACTGTGCGAGAGGG ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG GGTGATTACGTTTGGGGGAGTTATCGTCCCTACT TCAGCCCAAGGCTGCCCCCTCGGTCACTCTGTTC ACTACTACTACGGTATGGACGTCTGGGGCCAAG CCGCCCTCCTCTGAGGAGCTTCAAGCCAACAAG GGACCACGGTCACCGTCTCCTCAGCCTCCACCA GCCACACTGGTGTGTCTCATAAGTGACTTCTACC AGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTC CGGGAGCCGTGACAGTGGCCTGGAAGGCAGAT CAAGAGCACCTCTGGGGGCACAGCGGCCCTGGG AGCAGCCCCGTCAAGGCGGGAGTGGAGACCAC CTGCCTGGTCAAGGACTACTTCCCCGAACCGGT CACACCCTCCAAACAAAGCAACAACAAGTACGC GACGGTGTCGTGGAACTCAGGCGCCCTGACCAG GGCCAGCAGCTATCTGAGCCTGACGCCTGAGCA CGGCGTGCACACCTTCCCGGCTGTCCTACAGTCC GTGGAAGTCCCACAGAAGCTACAGCTGCCAGGT TCAGGACTCTACTCCCTCAGCAGCGTGGTGACC CACGCATGAAGGGAGCACCGTGGAGAAGACAG GTGCCCTCCAGCAGCTTGGGCACCCAGACCTAC TGGCCCCTACAGAATGTTCA ATCTGCAACGTGAATCACAAGCCCAGCAACACC SEQ ID NO: 2033 AAGGTGGACAAGAAAGTTGAGCCCAAATCTTGT GACAAAACTCACACATGCCCACCGTGCCCAGCA CCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCT TCCCCCCAAAACCCAAGGACACCCTCATGATCT CCCGGACCCCTGAGGTCACATGCGTGGTGGTGG ACGTGAGCCACGAAGACCCTGAGGTCAAGTTCA ACTGGTACGTGGACGGCGTGGAGGTGCATAATG CCAAGACAAAGCCGTGTGAGGAGCAGTACGGC AGCACGTACCGTTGTGTCAGCGTCCTCACCGTCC TGCACCAGGACTGGCTGAATGGCAAGGAGTACA AGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCC CCATCGAGAAAACCATCTCCAAAGCCAAAGGGC AGCCCCGAGAACCACAGGTGTACACCCTGCCCC CATCCCGGGAGGAGATGACCAAGAACCAGGTC AGCCTGACCTGCCTGGTCAAAGGCTTCTATCCC AGCGACATCGCCGTGGAGTGGGAGAGCAATGG GCAGCCGGAGAACAACTACAAGACCACGCCTCC CGTGCTGGACTCCGACGGCTCCTTCTTCCTCTAT AGCAAGCTCACCGTGGACAAGAGCAGGTGGCA GCAGGGGAACGTCTTCTCATGCTCCGTGATGCA TGAGGCTCTGCACAACCACTACACGCAGAAGAG CCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2190 AA QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS QMQLVQSGAEVKKPGASVKVSCKASGYTFTSYDI WYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGT NWVRQATGQGLEWMGWMNPNSGGTGYAQKFQ SATLGITGLQTGDEADYYCGTWDSSLSAVVFGGG GRVTMTRDTSISTAYMELSSLRSQDTAVYYCARG TKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLI GDYVWGSYRPYYYYYGMDVWGQGTTVTVSSAS SDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNN TKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPV KYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEK TVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVP TVAPTECS SSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH SEQ ID NO: 463 TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO: 620 iPS:361499 17B11.002.002 NA CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGCAGCTCCAACATTGGAAATAATTATG AAGGCTTCTGGATACACCTTCACCAGTTATGAT TATCCTGGTATCAGCAGCTCCCAGGAACAGCCC ATCAACTGGGTGCGACAGGCCACTGGACAAGGG CCAAACTCCTCATTTATGACAATAATAAGCGAC CTTGAGTGGATGGGATGGATGAACCCTAACAGT CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GGTAACACAGGCTATGCACAGAAGTTCCAGGGC GTCTGGCACGTCAGCCACCCTGGGCATCACCGG AGAGTCACCATGACCAGGGACACCTCCATAAGC ACTCCAGACTGGGGACGAGGCCGATTATTACTG ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT CGGAACATGGGATAGCAGCCTGAGTGCTGTGGT CAGGACACGGCCGTGTATTACTGTGCGAGAGGG ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG GGTGATTACGTTTGGGGGAGTTATCGTCCCTACT TCAGCCCAAGGCTGCCCCCTCGGTCACTCTGTTC ACTACTACTACGGTATGGACGTCTGGGGCCAAG CCGCCCTCCTCTGAGGAGCTTCAAGCCAACAAG GGACCACGGTCACCGTCTCCTCAGCCTCCACCA GCCACACTGGTGTGTCTCATAAGTGACTTCTACC AGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTC CGGGAGCCGTGACAGTGGCCTGGAAGGCAGAT CAAGAGCACCTCTGGGGGCACAGCGGCCCTGGG AGCAGCCCCGTCAAGGCGGGAGTGGAGACCAC CTGCCTGGTCAAGGACTACTTCCCCGAACCGGT CACACCCTCCAAACAAAGCAACAACAAGTACGC GACGGTGTCGTGGAACTCAGGCGCCCTGACCAG GGCCAGCAGCTATCTGAGCCTGACGCCTGAGCA CGGCGTGCACACCTTCCCGGCTGTCCTACAGTCC GTGGAAGTCCCACAGAAGCTACAGCTGCCAGGT TCAGGACTCTACTCCCTCAGCAGCGTGGTGACC CACGCATGAAGGGAGCACCGTGGAGAAGACAG GTGCCCTCCAGCAGCTTGGGCACCCAGACCTAC TGGCCCCTACAGAATGTTCA ATCTGCAACGTGAATCACAAGCCCAGCAACACC SEQ ID NO: 2034 AAGGTGGACAAGAAAGTTGAGCCCAAATCTTGT GACAAAACTCACACATGCCCACCGTGCCCAGCA CCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCT TCCCCCCAAAACCCAAGGACACCCTCATGATCT CCCGGACCCCTGAGGTCACATGCGTGGTGGTGG ACGTGAGCCACGAAGACCCTGAGGTCAAGTTCA ACTGGTACGTGGACGGCGTGGAGGTGCATAATG CCAAGACAAAGCCGTGTGAGGAGCAGTACGGC AGCACGTACCGTTGTGTCAGCGTCCTCACCGTCC TGCACCAGGACTGGCTGAATGGCAAGGAGTACA AGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCC CCATCGAGAAAACCATCTCCAAAGCCAAAGGGC AGCCCCGAGAACCACAGGTGTACACCCTGCCCC CATCCCGGGAGGAGATGACCAAGAACCAGGTC AGCCTGACCTGCCTGGTCAAAGGCTTCTATCCC AGCGACATCGCCGTGGAGTGGGAGAGCAATGG GCAGCCGGAGAACAACTACAAGACCACGCCTCC CGTGCTGGACTCCGACGGCTCCTTCTTCCTCTAT AGCAAGCTCACCGTGGACAAGAGCAGGTGGCA GCAGGGGAACGTCTTCTCATGCTCCGTGATGCA TGAGGCTCTGCACAACCACTACACGCAGAAGAG CCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2191 AA QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS QMQLVQSGAEVKKPGASVKVSCKASGYTFTSYDI WYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGT NWVRQATGQGLEWMGWMNPNSGNTGYAQKFQ SATLGITGLQTGDEADYYCGTWDSSLSAVVFGGG GRVTMTRDTSISTAYMELSSLRSQDTAVYYCARG TKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLI GDYVWGSYRPYYYYYGMDVWGQGTTVTVSSAS SDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNN TKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPV KYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEK TVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVP TVAPTECS SSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH SEQ ID NO: 464 TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO: 621 iPS:361503 17B11.002.003 NA CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGCAGCTCCAACATTGGAAATAATTATG AAGGCTTCTGGATACACCTTCACCAGTTATGAT TATCCTGGTATGAGCAGTTCCCAGGAACAGCCC ATCAACTGGGTGCGACAGGCCACTGGACAAGGG CCAAACTCCTCATTTATGACAATAATAAGCGAC CTTGAGTGGATGGGATGGATGAACCCTAACAGT CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GGTGGCACAGGCTATGCACAGAAGTTCCAGGGC GTCTGGCACGTCAGCCACCCTGGGCATCACCGG AGAGTCACCATGACCAGGGACACCTCCATAAGC ACTCCAGACTGGGGACGAGGCCGATTATTACTG ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT CGGAACATGGGATAGCAGCCTGAGTGCTGTGGT CAGGACACGGCCGTGTATTACTGTGCGAGAGGG ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG GGTGATTACGTTTGGGGGAGTTATCGTCCCTACT TCAGCCCAAGGCTGCCCCCTCGGTCACTCTGTTC ACTACTACTACGGTATGGACGTCTGGGGCCAAG CCGCCCTCCTCTGAGGAGCTTCAAGCCAACAAG GGACCACGGTCACCGTCTCCTCAGCCTCCACCA GCCACACTGGTGTGTCTCATAAGTGACTTCTACC AGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTC CGGGAGCCGTGACAGTGGCCTGGAAGGCAGAT CAAGAGCACCTCTGGGGGCACAGCGGCCCTGGG AGCAGCCCCGTCAAGGCGGGAGTGGAGACCAC CTGCCTGGTCAAGGACTACTTCCCCGAACCGGT CACACCCTCCAAACAAAGCAACAACAAGTACGC GACGGTGTCGTGGAACTCAGGCGCCCTGACCAG GGCCAGCAGCTATCTGAGCCTGACGCCTGAGCA CGGCGTGCACACCTTCCCGGCTGTCCTACAGTCC GTGGAAGTCCCACAGAAGCTACAGCTGCCAGGT TCAGGACTCTACTCCCTCAGCAGCGTGGTGACC CACGCATGAAGGGAGCACCGTGGAGAAGACAG GTGCCCTCCAGCAGCTTGGGCACCCAGACCTAC TGGCCCCTACAGAATGTTCA ATCTGCAACGTGAATCACAAGCCCAGCAACACC SEQ ID NO: 2035 AAGGTGGACAAGAAAGTTGAGCCCAAATCTTGT GACAAAACTCACACATGCCCACCGTGCCCAGCA CCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCT TCCCCCCAAAACCCAAGGACACCCTCATGATCT CCCGGACCCCTGAGGTCACATGCGTGGTGGTGG ACGTGAGCCACGAAGACCCTGAGGTCAAGTTCA ACTGGTACGTGGACGGCGTGGAGGTGCATAATG CCAAGACAAAGCCGTGTGAGGAGCAGTACGGC AGCACGTACCGTTGTGTCAGCGTCCTCACCGTCC TGCACCAGGACTGGCTGAATGGCAAGGAGTACA AGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCC CCATCGAGAAAACCATCTCCAAAGCCAAAGGGC AGCCCCGAGAACCACAGGTGTACACCCTGCCCC CATCCCGGGAGGAGATGACCAAGAACCAGGTC AGCCTGACCTGCCTGGTCAAAGGCTTCTATCCC AGCGACATCGCCGTGGAGTGGGAGAGCAATGG GCAGCCGGAGAACAACTACAAGACCACGCCTCC CGTGCTGGACTCCGACGGCTCCTTCTTCCTCTAT AGCAAGCTCACCGTGGACAAGAGCAGGTGGCA GCAGGGGAACGTCTTCTCATGCTCCGTGATGCA TGAGGCTCTGCACAACCACTACACGCAGAAGAG CCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2192 AA QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS QMQLVQSGAEVKKPGASVKVSCKASGYTFTSYDI WYEQFPGTAPKLLIYDNNKRPSGIPDRFSGSKSGTS NWVRQATGQGLEWMGWMNPNSGGTGYAQKFQ ATLGITGLQTGDEADYYCGTWDSSLSAVVFGGGT GRVTMTRDTSISTAYMELSSLRSQDTAVYYCARG KLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLIS GDYVWGSYRPYYYYYGMDVWGQGTTVTVSSAS DFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNK TKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPV YAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKT TVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVP VAPTECS SSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH SEQ ID NO: 465 TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO: 622 iPS:361507 17B11.002.004 NA CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGCAGCTCCAACATTGGAAATAATTATG AAGGCTTCTGGATACACCTTCACCAGTTATGAT TATCCTGGTATCAGCAGCTCCCAGGAACAGCCC ATCAACTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATTTATGACAATAATAAGCGAC CTTGAGTGGATGGGATGGATGAACCCTAACAGT CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GGTGGCACAGGCTATGCACAGAAGTTCCAGGGC GTCTGGCACGTCAGCCACCCTGGCCATCACCGG AGAGTCACCATGACCAGGGACACCTCCATAAGC ACTCCAGACTGGGGACGAGGCCGATTATTACTG ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT CGGAACATTCGAAAGCAGCCTGAGTGCTGTGGT GACGACACGGCCGTGTATTACTGTGCGAGAGGG ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG GGTGATTACGTTTGGGGGAGTTATCGTCCCTACT TCAGCCCAAGGCTGCCCCCTCGGTCACTCTGTTC ACTACTACTACGGTATGGACGTCTGGGGCCAAG CCGCCCTCCTCTGAGGAGCTTCAAGCCAACAAG GGACCACGGTCACCGTCTCCTCAGCCTCCACCA GCCACACTGGTGTGTCTCATAAGTGACTTCTACC AGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTC CGGGAGCCGTGACAGTGGCCTGGAAGGCAGAT CAAGAGCACCTCTGGGGGCACAGCGGCCCTGGG AGCAGCCCCGTCAAGGCGGGAGTGGAGACCAC CTGCCTGGTCAAGGACTACTTCCCCGAACCGGT CACACCCTCCAAACAAAGCAACAACAAGTACGC GACGGTGTCGTGGAACTCAGGCGCCCTGACCAG GGCCAGCAGCTATCTGAGCCTGACGCCTGAGCA CGGCGTGCACACCTTCCCGGCTGTCCTACAGTCC GTGGAAGTCCCACAGAAGCTACAGCTGCCAGGT TCAGGACTCTACTCCCTCAGCAGCGTGGTGACC CACGCATGAAGGGAGCACCGTGGAGAAGACAG GTGCCCTCCAGCAGCTTGGGCACCCAGACCTAC TGGCCCCTACAGAATGTTCA ATCTGCAACGTGAATCACAAGCCCAGCAACACC SEQ ID NO: 2036 AAGGTGGACAAGAAAGTTGAGCCCAAATCTTGT GACAAAACTCACACATGCCCACCGTGCCCAGCA CCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCT TCCCCCCAAAACCCAAGGACACCCTCATGATCT CCCGGACCCCTGAGGTCACATGCGTGGTGGTGG ACGTGAGCCACGAAGACCCTGAGGTCAAGTTCA ACTGGTACGTGGACGGCGTGGAGGTGCATAATG CCAAGACAAAGCCGTGTGAGGAGCAGTACGGC AGCACGTACCGTTGTGTCAGCGTCCTCACCGTCC TGCACCAGGACTGGCTGAATGGCAAGGAGTACA AGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCC CCATCGAGAAAACCATCTCCAAAGCCAAAGGGC AGCCCCGAGAACCACAGGTGTACACCCTGCCCC CATCCCGGGAGGAGATGACCAAGAACCAGGTC AGCCTGACCTGCCTGGTCAAAGGCTTCTATCCC AGCGACATCGCCGTGGAGTGGGAGAGCAATGG GCAGCCGGAGAACAACTACAAGACCACGCCTCC CGTGCTGGACTCCGACGGCTCCTTCTTCCTCTAT AGCAAGCTCACCGTGGACAAGAGCAGGTGGCA GCAGGGGAACGTCTTCTCATGCTCCGTGATGCA TGAGGCTCTGCACAACCACTACACGCAGAAGAG CCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2193 AA QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS QMQLVQSGAEVKKPGASVKVSCKASGYTFTSYDI WYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGT NWVRQAPGQGLEWMGWMNPNSGGTGYAQKFQ SATLAITGLQTGDEADYYCGTFESSLSAVVFGGGT GRVTMTRDTSISTAYMELSSLRSDDTAVYYCARG KLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLIS GDYVWGSYRPYYYYYGMDVWGQGTTVTVSSAS DFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNK TKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPV YAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKT TVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVP VAPTECS SSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH SEQ ID NO: 466 TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO: 623 iPS:361514 17B11.002.005 NA CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGCAGCTCCAACATTGGAAATAATTATG AAGGCTTCTGGATACACCTTCACCAGTTATGAT TATCCTGGTATCAGCAGCTCCCAGGAACAGCCC ATCAACTGGGTGCGACAGGCCACTGGACAAGGG CCAAACTCCTCATTTATGACAATAATAAGCGAC CTTGAGTGGATGGGATGGATGAACCCTAACAGT CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GGTGGCACAGGCTATGCACAGAAGTTCCAGGGC GTCTGGCACGTCAGCCACCCTGGCCATCACCGG AGAGTCACCATGACCAGGGACACCTCCATAAGC ACTCCAGACTGGGGACGAGGCCGATTATTACTG ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT CGGAACATGGGATAGCAGCCTGAGTGCTGTGGT CAGGACACGGCCGTGTATTACTGTGCGAGAGGG ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG GGTGATTACGTTTGGGGGAGTTATCGTCCCTACT TCAGCCCAAGGCTGCCCCCTCGGTCACTCTGTTC ACTACTACTACGGTATGGACGTCTGGGGCCAAG CCGCCCTCCTCTGAGGAGCTTCAAGCCAACAAG GGACCACGGTCACCGTCTCCTCAGCCTCCACCA GCCACACTGGTGTGTCTCATAAGTGACTTCTACC AGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTC CGGGAGCCGTGACAGTGGCCTGGAAGGCAGAT CAAGAGCACCTCTGGGGGCACAGCGGCCCTGGG AGCAGCCCCGTCAAGGCGGGAGTGGAGACCAC CTGCCTGGTCAAGGACTACTTCCCCGAACCGGT CACACCCTCCAAACAAAGCAACAACAAGTACGC GACGGTGTCGTGGAACTCAGGCGCCCTGACCAG GGCCAGCAGCTATCTGAGCCTGACGCCTGAGCA CGGCGTGCACACCTTCCCGGCTGTCCTACAGTCC GTGGAAGTCCCACAGAAGCTACAGCTGCCAGGT TCAGGACTCTACTCCCTCAGCAGCGTGGTGACC CACGCATGAAGGGAGCACCGTGGAGAAGACAG GTGCCCTCCAGCAGCTTGGGCACCCAGACCTAC TGGCCCCTACAGAATGTTCA ATCTGCAACGTGAATCACAAGCCCAGCAACACC SEQ ID NO: 2037 AAGGTGGACAAGAAAGTTGAGCCCAAATCTTGT GACAAAACTCACACATGCCCACCGTGCCCAGCA CCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCT TCCCCCCAAAACCCAAGGACACCCTCATGATCT CCCGGACCCCTGAGGTCACATGCGTGGTGGTGG ACGTGAGCCACGAAGACCCTGAGGTCAAGTTCA ACTGGTACGTGGACGGCGTGGAGGTGCATAATG CCAAGACAAAGCCGTGTGAGGAGCAGTACGGC AGCACGTACCGTTGTGTCAGCGTCCTCACCGTCC TGCACCAGGACTGGCTGAATGGCAAGGAGTACA AGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCC CCATCGAGAAAACCATCTCCAAAGCCAAAGGGC AGCCCCGAGAACCACAGGTGTACACCCTGCCCC CATCCCGGGAGGAGATGACCAAGAACCAGGTC AGCCTGACCTGCCTGGTCAAAGGCTTCTATCCC AGCGACATCGCCGTGGAGTGGGAGAGCAATGG GCAGCCGGAGAACAACTACAAGACCACGCCTCC CGTGCTGGACTCCGACGGCTCCTTCTTCCTCTAT AGCAAGCTCACCGTGGACAAGAGCAGGTGGCA GCAGGGGAACGTCTTCTCATGCTCCGTGATGCA TGAGGCTCTGCACAACCACTACACGCAGAAGAG CCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2194 AA QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS QMQLVQSGAEVKKPGASVKVSCKASGYTFTSYDI WYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGT NWVRQATGQGLEWMGWMNPNSGGTGYAQKFQ SATLAITGLQTGDEADYYCGTWDSSLSAVVFGGG GRVTMTRDTSISTAYMELSSLRSQDTAVYYCARG TKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLI GDYVWGSYRPYYYYYGMDVWGQGTTVTVSSAS SDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNN TKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPV KYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEK TVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVP TVAPTECS SSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH SEQ ID NO: 467 TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO: 624 iPS:360582 17B11.002.006 NA CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGCAGCTCCAACATTGGAAATAATTATG AAGGCTTCTGGATACACCTTCACCAGTTATGAT TATCCTGGTATCAGCAGCTCCCAGGAACAGCCC ATCAACTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATTTATGACAATAATAAGCGAC CTTGAGTGGATGGGATGGATGAACCCTAACAGT CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GGTAACACAGGCTATGCACAGAAGTTCCAGGGC GTCTGGCACGTCAGCCACCCTGGCCATCACCGG AGAGTCACCATGACCAGGGACACCTCCATAAGC ACTCCAGACTGGGGACGAGGCCGATTATTACTG ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT CGGAACATGGGATAGCAGCCTGAGTGCTGTGGT GACGACACGGCCGTGTATTACTGTGCGAGAGGG ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG GGTGATTACGTTTGGGGGAGTTATCGTCCCTACT TCAGCCCAAGGCTGCCCCCTCGGTCACTCTGTTC ACTACTACTACGGTATGGACGTCTGGGGCCAAG CCGCCCTCCTCTGAGGAGCTTCAAGCCAACAAG GGACCACGGTCACCGTCTCCTCAGCCTCCACCA GCCACACTGGTGTGTCTCATAAGTGACTTCTACC AGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTC CGGGAGCCGTGACAGTGGCCTGGAAGGCAGAT CAAGAGCACCTCTGGGGGCACAGCGGCCCTGGG AGCAGCCCCGTCAAGGCGGGAGTGGAGACCAC CTGCCTGGTCAAGGACTACTTCCCCGAACCGGT CACACCCTCCAAACAAAGCAACAACAAGTACGC GACGGTGTCGTGGAACTCAGGCGCCCTGACCAG GGCCAGCAGCTATCTGAGCCTGACGCCTGAGCA CGGCGTGCACACCTTCCCGGCTGTCCTACAGTCC GTGGAAGTCCCACAGAAGCTACAGCTGCCAGGT TCAGGACTCTACTCCCTCAGCAGCGTGGTGACC CACGCATGAAGGGAGCACCGTGGAGAAGACAG GTGCCCTCCAGCAGCTTGGGCACCCAGACCTAC TGGCCCCTACAGAATGTTCA ATCTGCAACGTGAATCACAAGCCCAGCAACACC SEQ ID NO: 2038 AAGGTGGACAAGAAAGTTGAGCCCAAATCTTGT GACAAAACTCACACATGCCCACCGTGCCCAGCA CCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCT TCCCCCCAAAACCCAAGGACACCCTCATGATCT CCCGGACCCCTGAGGTCACATGCGTGGTGGTGG ACGTGAGCCACGAAGACCCTGAGGTCAAGTTCA ACTGGTACGTGGACGGCGTGGAGGTGCATAATG CCAAGACAAAGCCGTGTGAGGAGCAGTACGGC AGCACGTACCGTTGTGTCAGCGTCCTCACCGTCC TGCACCAGGACTGGCTGAATGGCAAGGAGTACA AGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCC CCATCGAGAAAACCATCTCCAAAGCCAAAGGGC AGCCCCGAGAACCACAGGTGTACACCCTGCCCC CATCCCGGGAGGAGATGACCAAGAACCAGGTC AGCCTGACCTGCCTGGTCAAAGGCTTCTATCCC AGCGACATCGCCGTGGAGTGGGAGAGCAATGG GCAGCCGGAGAACAACTACAAGACCACGCCTCC CGTGCTGGACTCCGACGGCTCCTTCTTCCTCTAT AGCAAGCTCACCGTGGACAAGAGCAGGTGGCA GCAGGGGAACGTCTTCTCATGCTCCGTGATGCA TGAGGCTCTGCACAACCACTACACGCAGAAGAG CCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2195 AA QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS QMQLVQSGAEVKKPGASVKVSCKASGYTFTSYDI WYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGT NWVRQAPGQGLEWMGWMNPNSGNTGYAQKFQ SATLAITGLQTGDEADYYCGTWDSSLSAVVFGGG GRVTMTRDTSISTAYMELSSLRSDDTAVYYCARG TKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLI GDYVWGSYRPYYYYYGMDVWGQGTTVTVSSAS SDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNN TKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPV KYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEK TVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVP TVAPTECS SSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH SEQ ID NO: 468 TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO: 625 iPS:361518 17B11.002.007 NA CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGCAGCTCCAACATTGGAAATAATTATG AAGGCTTCTGGATACACCTTCACCAGTTATGAT TATCCTGGTATCAGCAGCTCCCAGGAACAGCCC ATCAACTGGGTGCGACAGGCCACTGGACAAGGG CCAAACTCCTCATTTATGACAATAATAAGCGAC CTTGAGTGGATGGGATGGATGAACCCTAACAGT CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GGTGGCACAGGCTATGCACAGAAGTTCCAGGGC GTCTGGCACGTCAGCCACCCTGGGCATCACCGG AGAGTCACCATGACCAGGGACACCTCCATAAGC ACTCCAGACTGGGGACGAGGCCGATTATTACTG ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT CGGAACATGGGATAGCAGCCTGAGTGCTGTGGT CAGGACACGGCCGTGTATTACTGTGCGAGAGGG ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG GGTGATTACGTTTTCGGGAGTTATCGTCCCTACT TCAGCCCAAGGCTGCCCCCTCGGTCACTCTGTTC ACTACTACTACGGTATGGACGTCTGGGGCCAAG CCGCCCTCCTCTGAGGAGCTTCAAGCCAACAAG GGACCACGGTCACCGTCTCCTCAGCCTCCACCA GCCACACTGGTGTGTCTCATAAGTGACTTCTACC AGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTC CGGGAGCCGTGACAGTGGCCTGGAAGGCAGAT CAAGAGCACCTCTGGGGGCACAGCGGCCCTGGG AGCAGCCCCGTCAAGGCGGGAGTGGAGACCAC CTGCCTGGTCAAGGACTACTTCCCCGAACCGGT CACACCCTCCAAACAAAGCAACAACAAGTACGC GACGGTGTCGTGGAACTCAGGCGCCCTGACCAG GGCCAGCAGCTATCTGAGCCTGACGCCTGAGCA CGGCGTGCACACCTTCCCGGCTGTCCTACAGTCC GTGGAAGTCCCACAGAAGCTACAGCTGCCAGGT TCAGGACTCTACTCCCTCAGCAGCGTGGTGACC CACGCATGAAGGGAGCACCGTGGAGAAGACAG GTGCCCTCCAGCAGCTTGGGCACCCAGACCTAC TGGCCCCTACAGAATGTTCA ATCTGCAACGTGAATCACAAGCCCAGCAACACC SEQ ID NO: 2039 AAGGTGGACAAGAAAGTTGAGCCCAAATCTTGT GACAAAACTCACACATGCCCACCGTGCCCAGCA CCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCT TCCCCCCAAAACCCAAGGACACCCTCATGATCT CCCGGACCCCTGAGGTCACATGCGTGGTGGTGG ACGTGAGCCACGAAGACCCTGAGGTCAAGTTCA ACTGGTACGTGGACGGCGTGGAGGTGCATAATG CCAAGACAAAGCCGTGTGAGGAGCAGTACGGC AGCACGTACCGTTGTGTCAGCGTCCTCACCGTCC TGCACCAGGACTGGCTGAATGGCAAGGAGTACA AGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCC CCATCGAGAAAACCATCTCCAAAGCCAAAGGGC AGCCCCGAGAACCACAGGTGTACACCCTGCCCC CATCCCGGGAGGAGATGACCAAGAACCAGGTC AGCCTGACCTGCCTGGTCAAAGGCTTCTATCCC AGCGACATCGCCGTGGAGTGGGAGAGCAATGG GCAGCCGGAGAACAACTACAAGACCACGCCTCC CGTGCTGGACTCCGACGGCTCCTTCTTCCTCTAT AGCAAGCTCACCGTGGACAAGAGCAGGTGGCA GCAGGGGAACGTCTTCTCATGCTCCGTGATGCA TGAGGCTCTGCACAACCACTACACGCAGAAGAG CCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2196 AA QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS QMQLVQSGAEVKKPGASVKVSCKASGYTFTSYDI WYQQLPGTAPKWYDNNKRPSGIPDRFSGSKSGT NWVRQATGQGLEWMGWMNPNSGGTGYAQKFQ SATLGITGLQTGDEADYYCGTWDSSLSAVVFGGG GRVTMTRDTSISTAYMELSSLRSQDTAVYYCARG TKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLI GDYVFGSYRPYYYYYGMDVWGQGTTVTVSSAST SDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNN KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT KYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEK VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS TVAPTECS SSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH SEQ ID NO: 469 TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO: 626 iPS:360570 17B11.002.008 NA CAGTCTGTGTTGACGCAGCCGCCCTCAGTGTCTG CAAATGCAGCTGGTGCAGTCTGGGGCTGAGGTG CGGCCCCAGGACAGAAGGTCACCATCTCCTGCT AAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGC CTGGAAGCAGCTCCAACATTGGAAATAATTATG AAGGCTTCTGGATACACCTTCACCAGTTATGAT TATCCTGGTATCAGCAGCTCCCAGGAACAGCCC ATCAACTGGGTGCGACAGGCCCCTGGACAAGGG CCAAACTCCTCATTTATGACAATAATAAGCGAC CTTGAGTGGATGGGATGGATGAACCCTAACAGT CCTCAGGGATTCCTGACCGATTCTCTGGCTCCAA GGTGGCACAGGCTATGCACAGAAGTTCCAGGGC GTCTGGCACGTCAGCCACCCTGGCCATCACCGG AGAGTCACCATGACCAGGGACACCTCCATAAGC ACTCCAGACTGGGGACGAGGCCGATTATTACTG ACAGCCTACATGGAGCTGAGCAGCCTGAGATCT CGGAACATTCGAAAGCAGCCTGAGTGCTGTGGT GACGACACGGCCGTGTATTACTGTGCGAGAGGG ATTCGGCGGAGGGACCAAACTGACCGTCCTAGG GGTGATTACGTTTTCGGGAGTTATCGTCCCTACT TCAGCCCAAGGCTGCCCCCTCGGTCACTCTGTTC ACTACTACTACGGTATGGACGTCTGGGGCCAAG CCGCCCTCCTCTGAGGAGCTTCAAGCCAACAAG GGACCACGGTCACCGTCTCCTCAGCCTCCACCA GCCACACTGGTGTGTCTCATAAGTGACTTCTACC AGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTC CGGGAGCCGTGACAGTGGCCTGGAAGGCAGAT CAAGAGCACCTCTGGGGGCACAGCGGCCCTGGG AGCAGCCCCGTCAAGGCGGGAGTGGAGACCAC CTGCCTGGTCAAGGACTACTTCCCCGAACCGGT CACACCCTCCAAACAAAGCAACAACAAGTACGC GACGGTGTCGTGGAACTCAGGCGCCCTGACCAG GGCCAGCAGCTATCTGAGCCTGACGCCTGAGCA CGGCGTGCACACCTTCCCGGCTGTCCTACAGTCC GTGGAAGTCCCACAGAAGCTACAGCTGCCAGGT TCAGGACTCTACTCCCTCAGCAGCGTGGTGACC CACGCATGAAGGGAGCACCGTGGAGAAGACAG GTGCCCTCCAGCAGCTTGGGCACCCAGACCTAC TGGCCCCTACAGAATGTTCA ATCTGCAACGTGAATCACAAGCCCAGCAACACC SEQ ID NO: 2040 AAGGTGGACAAGAAAGTTGAGCCCAAATCTTGT GACAAAACTCACACATGCCCACCGTGCCCAGCA CCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCT TCCCCCCAAAACCCAAGGACACCCTCATGATCT CCCGGACCCCTGAGGTCACATGCGTGGTGGTGG ACGTGAGCCACGAAGACCCTGAGGTCAAGTTCA ACTGGTACGTGGACGGCGTGGAGGTGCATAATG CCAAGACAAAGCCGTGTGAGGAGCAGTACGGC AGCACGTACCGTTGTGTCAGCGTCCTCACCGTCC TGCACCAGGACTGGCTGAATGGCAAGGAGTACA AGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCC CCATCGAGAAAACCATCTCCAAAGCCAAAGGGC AGCCCCGAGAACCACAGGTGTACACCCTGCCCC CATCCCGGGAGGAGATGACCAAGAACCAGGTC AGCCTGACCTGCCTGGTCAAAGGCTTCTATCCC AGCGACATCGCCGTGGAGTGGGAGAGCAATGG GCAGCCGGAGAACAACTACAAGACCACGCCTCC CGTGCTGGACTCCGACGGCTCCTTCTTCCTCTAT AGCAAGCTCACCGTGGACAAGAGCAGGTGGCA GCAGGGGAACGTCTTCTCATGCTCCGTGATGCA TGAGGCTCTGCACAACCACTACACGCAGAAGAG CCTCTCCCTGTCTCCGGGTAAA SEQ ID NO: 2197 AA QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVS QMQLVQSGAEVKKPGASVKVSCKASGYTFTSYDI WYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGT NWVRQAPGQGLEWMGWMNPNSGGTGYAQKFQ SATLAITGLQTGDEADYYCGTFESSLSAVVFGGGT GRVTMTRDTSISTAYMELSSLRSDDTAVYYCARG KLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLIS GDYVFGSYRPYYYYYGMDVWGQGTTVTVSSAST DFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNK KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVT YAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKT VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS VAPTECS SSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH SEQ ID NO: 470 TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPCE EQYGSTYRCVSVLTVLHQDWLNGKEYKCKVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV LDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGK SEQ ID NO: 627 iPS:362051 5G12.005.001 NA GACATCCAGCTGACCCAGTCTCCATCCTCCCTGT CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTG CTGCATCTGTAGGAGACAGAGTCACTATCACTT GTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGT GCCGGGCAAGTCAGACCATTAGCAGGTTTTTAA GCAGCGTCTGGATTCACCTTCAGTAGCTATGGC ATTGGTATCAGCAGAAACCTGGGAAAGCCCCTA ATACACTGGGTCCGCCAGGCTCCAGGCAAGGGG AGCTCCTGATCTATGTTGCATCCAGTTTGCAAAG CTGGAGTGGGTGGCAGTTATATGGTATGATGCA TGGGGTCCCATCAAGATTCAGTGGCAGTGGTTC AGTAATAAGTTCCATGCAGACGCCGTGAAGGGC TGGGACAGATTTCACTCTCACCATCAGCAGTCT CGATTCACCATCTCCAGAGACAATTCCAAGAAC GCAACCTGAAGATTTTGCAACTTACTACTGTCA ACGCTGTATCTGCAAATGAACAGCCTGAGAGCC ACAGAGTTACAGTACCCTGCTCAGTTTTGGCCA GAGGACTCGGCTATGTACTTCTGTGCGAGAGGA GGGGACCAAGCTGGAGATCAAACGAACGGTGG AAAGTGGCTGGTATGCCTGAAGCTTTTGAAATC CTGCACCATCTGTCTTCATCTTCCCGCCATCTGA TGGGGCCAAGGGACATTGGTCACCGTCTCTTCA TGAGCAGTTGAAATCTGGAACTGCCTCTGTTGT GCCTCCACCAAGGGCCCATCGGTCTTCCCCCTG GTGCCTGCTGAATAACTTCTATCCCAGAGAGGC GCACCCTCCTCCAAGAGCACCTCTGGGGGCACA CAAAGTACAGTGGAAGGTGGATAACGCCCTCCA GCGGCCCTGGGCTGCCTGGTCAAGGACTACTTC ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCA CCCGAACCGGTGACGGTGTCGTGGAACTCAGGC GGACAGCAAGGACAGCACCTACAGCCTCAGCA GCCCTGACCAGCGGCGTGCACACCTTCCCGGCT GCACCCTGACGCTGAGCAAAGCAGACTACGAGA GTCCTACAGTCCTCAGGACTCTACTCCCTCAGCA AACACAAAGTCTACGCCTGCGAAGTCACCCATC GCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCA AGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCA CCCAGACCTACATCTGCAACGTGAATCACAAGC ACAGGGGAGAGTGT CCAGCAACACCAAGGTGGACAAGAAAGTTGAG SEQ ID NO: 2041 CCCAAATCTTGTGACAAAACTCACACATGCCCA CCGTGCCCAGCACCTGAACTCCTGGGGGGACCG TCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACA CCCTCATGATCTCCCGGACCCCTGAGGTCACAT GCGTGGTGGTGGACGTGAGCCACGAAGACCCTG AGGTCAAGTTCAACTGGTACGTGGACGGCGTGG AGGTGCATAATGCCAAGACAAAGCCGTGTGAGG AGCAGTACGGCAGCACGTACCGTTGTGTCAGCG TCCTCACCGTCCTGCACCAGGACTGGCTGAATG GCAAGGAGTACAAGTGCAAGGTCTCCAACAAA GCCCTCCCAGCCCCCATCGAGAAAACCATCTCC AAAGCCAAAGGGCAGCCCCGAGAACCACAGGT GTACACCCTGCCCCCATCCCGGGAGGAGATGAC CAAGAACCAGGTCAGCCTGACCTGCCTGGTCAA AGGCTTCTATCCCAGCGACATCGCCGTGGAGTG GGAGAGCAATGGGCAGCCGGAGAACAACTACA AGACCACGCCTCCCGTGCTGGACTCCGACGGCT CCTTCTTCCTCTATAGCAAGCTCACCGTGGACAA GAGCAGGTGGCAGCAGGGGAACGTCTTCTCATG CTCCGTGATGCATGAGGCTCTGCACAACCACTA CACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAA A SEQ ID NO: 2198 AA DIQLTQSPSSLSASVGDRVTITCRASQTISRFLNWY QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGIH QQKPGKAPKLLIYVASSLQSGVPSRFSGSGSGTDF WVRQAPGKGLEWVAVIWYDASNKFHADAVKGR TLTISSLQPEDFATYYCQQSYSTLLSFGQGTKLEIK FTISRDNSKNTLYLQMNSLRAEDSAMYFCARGKV RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE AGMPEAFEIWGQGTLVTVSSASTKGPSVFPLAPSS AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSS KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSG TLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV GEC NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG SEQ ID NO: 471 GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE VKFNWYVDGVEVHNAKTKPCEEQYGSTYRCVSV LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYP SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK SEQ ID NO: 628

In one embodiment the antibody or fragment thereof comprises a light chain variable region comprising a sequence selected from the group consisting of SEQ ID NOs: 1-157 and a heavy chain variable region comprising a sequence selected from the group consisting of SEQ ID NOs: 158-314, wherein the antibody or functional fragment thereof comprises a cysteine or non-canonical amino acid amino acid substitution at one or more conjugation site(s) selected from the group consisting of D70 of the antibody light chain relative to reference sequence SEQ ID NO: 455, E276 of the antibody heavy chain relative to reference sequence SEQ ID NO: 612, and T363 of the antibody heavy chain relative to reference sequence SEQ ID NO: 612.

In one embodiment the antibody or fragment thereof comprises a combination of light chain variable region and a heavy chain variable region selected from the group consisting of a light chain variable region comprising SEQ ID NO: 1 and a heavy chain variable region comprising SEQ ID NO: 158; a light chain variable region comprising SEQ ID NO: 2 and a heavy chain variable region comprising SEQ ID NO: 159; a light chain variable region comprising SEQ ID NO: 3 and a heavy chain variable region comprising SEQ ID NO: 160; a light chain variable region comprising SEQ ID NO: 4 and a heavy chain variable region comprising SEQ ID NO: 161; a light chain variable region comprising SEQ ID NO: 5 and a heavy chain variable region comprising SEQ ID NO: 162; a light chain variable region comprising SEQ ID NO: 6 and a heavy chain variable region comprising SEQ ID NO: 163; a light chain variable region comprising SEQ ID NO: 7 and a heavy chain variable region comprising SEQ ID NO: 164; a light chain variable region comprising SEQ ID NO: 8 and a heavy chain variable region comprising SEQ ID NO: 165; a light chain variable region comprising SEQ ID NO: 9 and a heavy chain variable region comprising SEQ ID NO: 166; a light chain variable region comprising SEQ ID NO: 10 and a heavy chain variable region comprising SEQ ID NO: 167; a light chain variable region comprising SEQ ID NO: 11 and a heavy chain variable region comprising SEQ ID NO: 168; a light chain variable region comprising SEQ ID NO: 12 and a heavy chain variable region comprising SEQ ID NO: 169; a light chain variable region comprising SEQ ID NO: 13 and a heavy chain variable region comprising SEQ ID NO: 170; a light chain variable region comprising SEQ ID NO: 14 and a heavy chain variable region comprising SEQ ID NO: 171; a light chain variable region comprising SEQ ID NO: 15 and a heavy chain variable region comprising SEQ ID NO: 172; a light chain variable region comprising SEQ ID NO: 16 and a heavy chain variable region comprising SEQ ID NO: 173; a light chain variable region comprising SEQ ID NO: 17 and a heavy chain variable region comprising SEQ ID NO: 174; a light chain variable region comprising SEQ ID NO: 18 and a heavy chain variable region comprising SEQ ID NO: 175; a light chain variable region comprising SEQ ID NO: 19 and a heavy chain variable region comprising SEQ ID NO: 176; a light chain variable region comprising SEQ ID NO: 20 and a heavy chain variable region comprising SEQ ID NO: 177; a light chain variable region comprising SEQ ID NO: 21 and a heavy chain variable region comprising SEQ ID NO: 178; a light chain variable region comprising SEQ ID NO: 22 and a heavy chain variable region comprising SEQ ID NO: 179; a light chain variable region comprising SEQ ID NO: 23 and a heavy chain variable region comprising SEQ ID NO: 180; a light chain variable region comprising SEQ ID NO: 24 and a heavy chain variable region comprising SEQ ID NO: 181; a light chain variable region comprising SEQ ID NO: 25 and a heavy chain variable region comprising SEQ ID NO: 182; a light chain variable region comprising SEQ ID NO: 26 and a heavy chain variable region comprising SEQ ID NO: 183; a light chain variable region comprising SEQ ID NO: 27 and a heavy chain variable region comprising SEQ ID NO: 184; a light chain variable region comprising SEQ ID NO: 28 and a heavy chain variable region comprising SEQ ID NO: 185; a light chain variable region comprising SEQ ID NO: 29 and a heavy chain variable region comprising SEQ ID NO: 186; a light chain variable region comprising SEQ ID NO: 30 and a heavy chain variable region comprising SEQ ID NO: 187; a light chain variable region comprising SEQ ID NO: 31 and a heavy chain variable region comprising SEQ ID NO: 188; a light chain variable region comprising SEQ ID NO: 32 and a heavy chain variable region comprising SEQ ID NO: 189; a light chain variable region comprising SEQ ID NO: 33 and a heavy chain variable region comprising SEQ ID NO: 190; a light chain variable region comprising SEQ ID NO: 34 and a heavy chain variable region comprising SEQ ID NO: 191; a light chain variable region comprising SEQ ID NO: 35 and a heavy chain variable region comprising SEQ ID NO: 192; a light chain variable region comprising SEQ ID NO: 36 and a heavy chain variable region comprising SEQ ID NO: 193; a light chain variable region comprising SEQ ID NO: 37 and a heavy chain variable region comprising SEQ ID NO: 194; a light chain variable region comprising SEQ ID NO: 38 and a heavy chain variable region comprising SEQ ID NO: 195; a light chain variable region comprising SEQ ID NO: 39 and a heavy chain variable region comprising SEQ ID NO: 196; a light chain variable region comprising SEQ ID NO: 40 and a heavy chain variable region comprising SEQ ID NO: 197; a light chain variable region comprising SEQ ID NO: 41 and a heavy chain variable region comprising SEQ ID NO: 198; a light chain variable region comprising SEQ ID NO: 42 and a heavy chain variable region comprising SEQ ID NO: 199; a light chain variable region comprising SEQ ID NO: 43 and a heavy chain variable region comprising SEQ ID NO: 200; a light chain variable region comprising SEQ ID NO: 44 and a heavy chain variable region comprising SEQ ID NO: 201; a light chain variable region comprising SEQ ID NO: 45 and a heavy chain variable region comprising SEQ ID NO: 202; a light chain variable region comprising SEQ ID NO: 46 and a heavy chain variable region comprising SEQ ID NO: 203; a light chain variable region comprising SEQ ID NO: 47 and a heavy chain variable region comprising SEQ ID NO: 204; a light chain variable region comprising SEQ ID NO: 48 and a heavy chain variable region comprising SEQ ID NO: 205; a light chain variable region comprising SEQ ID NO: 49 and a heavy chain variable region comprising SEQ ID NO: 206; a light chain variable region comprising SEQ ID NO: 50 and a heavy chain variable region comprising SEQ ID NO: 207; a light chain variable region comprising SEQ ID NO: 51 and a heavy chain variable region comprising SEQ ID NO: 208; a light chain variable region comprising SEQ ID NO: 52 and a heavy chain variable region comprising SEQ ID NO: 209; a light chain variable region comprising SEQ ID NO: 53 and a heavy chain variable region comprising SEQ ID NO: 210; a light chain variable region comprising SEQ ID NO: 54 and a heavy chain variable region comprising SEQ ID NO: 211; a light chain variable region comprising SEQ ID NO: 55 and a heavy chain variable region comprising SEQ ID NO: 212; a light chain variable region comprising SEQ ID NO: 56 and a heavy chain variable region comprising SEQ ID NO: 213; a light chain variable region comprising SEQ ID NO: 57 and a heavy chain variable region comprising SEQ ID NO: 214; a light chain variable region comprising SEQ ID NO: 58 and a heavy chain variable region comprising SEQ ID NO: 215; a light chain variable region comprising SEQ ID NO: 59 and a heavy chain variable region comprising SEQ ID NO: 216; a light chain variable region comprising SEQ ID NO: 60 and a heavy chain variable region comprising SEQ ID NO: 217; a light chain variable region comprising SEQ ID NO: 61 and a heavy chain variable region comprising SEQ ID NO: 218; a light chain variable region comprising SEQ ID NO: 62 and a heavy chain variable region comprising SEQ ID NO: 219; a light chain variable region comprising SEQ ID NO: 63 and a heavy chain variable region comprising SEQ ID NO: 220; a light chain variable region comprising SEQ ID NO: 64 and a heavy chain variable region comprising SEQ ID NO: 221; a light chain variable region comprising SEQ ID NO: 65 and a heavy chain variable region comprising SEQ ID NO: 222; a light chain variable region comprising SEQ ID NO: 66 and a heavy chain variable region comprising SEQ ID NO: 223; a light chain variable region comprising SEQ ID NO: 67 and a heavy chain variable region comprising SEQ ID NO: 224; a light chain variable region comprising SEQ ID NO: 68 and a heavy chain variable region comprising SEQ ID NO: 225; a light chain variable region comprising SEQ ID NO: 69 and a heavy chain variable region comprising SEQ ID NO: 226; a light chain variable region comprising SEQ ID NO: 70 and a heavy chain variable region comprising SEQ ID NO: 227; a light chain variable region comprising SEQ ID NO: 71 and a heavy chain variable region comprising SEQ ID NO: 228; a light chain variable region comprising SEQ ID NO: 72 and a heavy chain variable region comprising SEQ ID NO: 229; a light chain variable region comprising SEQ ID NO: 73 and a heavy chain variable region comprising SEQ ID NO: 230; a light chain variable region comprising SEQ ID NO: 74 and a heavy chain variable region comprising SEQ ID NO: 231; a light chain variable region comprising SEQ ID NO: 75 and a heavy chain variable region comprising SEQ ID NO: 232; a light chain variable region comprising SEQ ID NO: 76 and a heavy chain variable region comprising SEQ ID NO: 233; a light chain variable region comprising SEQ ID NO: 77 and a heavy chain variable region comprising SEQ ID NO: 234; a light chain variable region comprising SEQ ID NO: 78 and a heavy chain variable region comprising SEQ ID NO: 235; a light chain variable region comprising SEQ ID NO: 79 and a heavy chain variable region comprising SEQ ID NO: 236; a light chain variable region comprising SEQ ID NO: 80 and a heavy chain variable region comprising SEQ ID NO: 237; a light chain variable region comprising SEQ ID NO: 81 and a heavy chain variable region comprising SEQ ID NO: 238; a light chain variable region comprising SEQ ID NO: 82 and a heavy chain variable region comprising SEQ ID NO: 239; a light chain variable region comprising SEQ ID NO: 83 and a heavy chain variable region comprising SEQ ID NO: 240; a light chain variable region comprising SEQ ID NO: 84 and a heavy chain variable region comprising SEQ ID NO: 241; a light chain variable region comprising SEQ ID NO: 85 and a heavy chain variable region comprising SEQ ID NO: 242; a light chain variable region comprising SEQ ID NO: 86 and a heavy chain variable region comprising SEQ ID NO: 243; a light chain variable region comprising SEQ ID NO: 87 and a heavy chain variable region comprising SEQ ID NO: 244; a light chain variable region comprising SEQ ID NO: 88 and a heavy chain variable region comprising SEQ ID NO: 245; a light chain variable region comprising SEQ ID NO: 89 and a heavy chain variable region comprising SEQ ID NO: 246; a light chain variable region comprising SEQ ID NO: 90 and a heavy chain variable region comprising SEQ ID NO: 247; a light chain variable region comprising SEQ ID NO: 91 and a heavy chain variable region comprising SEQ ID NO: 248; a light chain variable region comprising SEQ ID NO: 92 and a heavy chain variable region comprising SEQ ID NO: 249; a light chain variable region comprising SEQ ID NO: 93 and a heavy chain variable region comprising SEQ ID NO: 250; a light chain variable region comprising SEQ ID NO: 94 and a heavy chain variable region comprising SEQ ID NO: 251; a light chain variable region comprising SEQ ID NO: 95 and a heavy chain variable region comprising SEQ ID NO: 252; a light chain variable region comprising SEQ ID NO: 96 and a heavy chain variable region comprising SEQ ID NO: 253; a light chain variable region comprising SEQ ID NO: 97 and a heavy chain variable region comprising SEQ ID NO: 254; a light chain variable region comprising SEQ ID NO: 98 and a heavy chain variable region comprising SEQ ID NO: 255; a light chain variable region comprising SEQ ID NO: 99 and a heavy chain variable region comprising SEQ ID NO: 256; a light chain variable region comprising SEQ ID NO: 100 and a heavy chain variable region comprising SEQ ID NO: 257; a light chain variable region comprising SEQ ID NO: 101 and a heavy chain variable region comprising SEQ ID NO: 258; a light chain variable region comprising SEQ ID NO: 102 and a heavy chain variable region comprising SEQ ID NO: 259; a light chain variable region comprising SEQ ID NO: 103 and a heavy chain variable region comprising SEQ ID NO: 260; a light chain variable region comprising SEQ ID NO: 104 and a heavy chain variable region comprising SEQ ID NO: 261; a light chain variable region comprising SEQ ID NO: 105 and a heavy chain variable region comprising SEQ ID NO: 262; a light chain variable region comprising SEQ ID NO: 106 and a heavy chain variable region comprising SEQ ID NO: 263; a light chain variable region comprising SEQ ID NO: 107 and a heavy chain variable region comprising SEQ ID NO: 264; a light chain variable region comprising SEQ ID NO: 108 and a heavy chain variable region comprising SEQ ID NO: 265; a light chain variable region comprising SEQ ID NO: 109 and a heavy chain variable region comprising SEQ ID NO: 266; a light chain variable region comprising SEQ ID NO: 110 and a heavy chain variable region comprising SEQ ID NO: 267; a light chain variable region comprising SEQ ID NO: 111 and a heavy chain variable region comprising SEQ ID NO: 268; a light chain variable region comprising SEQ ID NO: 112 and a heavy chain variable region comprising SEQ ID NO: 269; a light chain variable region comprising SEQ ID NO: 113 and a heavy chain variable region comprising SEQ ID NO: 270; a light chain variable region comprising SEQ ID NO: 114 and a heavy chain variable region comprising SEQ ID NO: 271; a light chain variable region comprising SEQ ID NO: 115 and a heavy chain variable region comprising SEQ ID NO: 272; a light chain variable region comprising SEQ ID NO: 116 and a heavy chain variable region comprising SEQ ID NO: 273; a light chain variable region comprising SEQ ID NO: 117 and a heavy chain variable region comprising SEQ ID NO: 274; a light chain variable region comprising SEQ ID NO: 118 and a heavy chain variable region comprising SEQ ID NO: 275; a light chain variable region comprising SEQ ID NO: 119 and a heavy chain variable region comprising SEQ ID NO: 276; a light chain variable region comprising SEQ ID NO: 120 and a heavy chain variable region comprising SEQ ID NO: 277; a light chain variable region comprising SEQ ID NO: 121 and a heavy chain variable region comprising SEQ ID NO: 278; a light chain variable region comprising SEQ ID NO: 122 and a heavy chain variable region comprising SEQ ID NO: 279; a light chain variable region comprising SEQ ID NO: 123 and a heavy chain variable region comprising SEQ ID NO: 280; a light chain variable region comprising SEQ ID NO: 124 and a heavy chain variable region comprising SEQ ID NO: 281; a light chain variable region comprising SEQ ID NO: 125 and a heavy chain variable region comprising SEQ ID NO: 282; a light chain variable region comprising SEQ ID NO: 126 and a heavy chain variable region comprising SEQ ID NO: 283; a light chain variable region comprising SEQ ID NO: 127 and a heavy chain variable region comprising SEQ ID NO: 284; a light chain variable region comprising SEQ ID NO: 128 and a heavy chain variable region comprising SEQ ID NO: 285; a light chain variable region comprising SEQ ID NO: 129 and a heavy chain variable region comprising SEQ ID NO: 286; a light chain variable region comprising SEQ ID NO: 130 and a heavy chain variable region comprising SEQ ID NO: 287; a light chain variable region comprising SEQ ID NO: 131 and a heavy chain variable region comprising SEQ ID NO: 288; a light chain variable region comprising SEQ ID NO: 132 and a heavy chain variable region comprising SEQ ID NO: 289; a light chain variable region comprising SEQ ID NO: 133 and a heavy chain variable region comprising SEQ ID NO: 290; a light chain variable region comprising SEQ ID NO: 134 and a heavy chain variable region comprising SEQ ID NO: 291; a light chain variable region comprising SEQ ID NO: 135 and a heavy chain variable region comprising SEQ ID NO: 292; a light chain variable region comprising SEQ ID NO: 136 and a heavy chain variable region comprising SEQ ID NO: 293; a light chain variable region comprising SEQ ID NO: 137 and a heavy chain variable region comprising SEQ ID NO: 294; a light chain variable region comprising SEQ ID NO: 138 and a heavy chain variable region comprising SEQ ID NO: 295; a light chain variable region comprising SEQ ID NO: 139 and a heavy chain variable region comprising SEQ ID NO: 296; a light chain variable region comprising SEQ ID NO: 140 and a heavy chain variable region comprising SEQ ID NO: 297; a light chain variable region comprising SEQ ID NO: 141 and a heavy chain variable region comprising SEQ ID NO: 298; a light chain variable region comprising SEQ ID NO: 142 and a heavy chain variable region comprising SEQ ID NO: 299; a light chain variable region comprising SEQ ID NO: 143 and a heavy chain variable region comprising SEQ ID NO: 300; a light chain variable region comprising SEQ ID NO: 144 and a heavy chain variable region comprising SEQ ID NO: 301; a light chain variable region comprising SEQ ID NO: 145 and a heavy chain variable region comprising SEQ ID NO: 302; a light chain variable region comprising SEQ ID NO: 146 and a heavy chain variable region comprising SEQ ID NO: 303; a light chain variable region comprising SEQ ID NO: 147 and a heavy chain variable region comprising SEQ ID NO: 304; a light chain variable region comprising SEQ ID NO: 148 and a heavy chain variable region comprising SEQ ID NO: 305; a light chain variable region comprising SEQ ID NO: 149 and a heavy chain variable region comprising SEQ ID NO: 306; a light chain variable region comprising SEQ ID NO: 150 and a heavy chain variable region comprising SEQ ID NO: 307; a light chain variable region comprising SEQ ID NO: 151 and a heavy chain variable region comprising SEQ ID NO: 308; a light chain variable region comprising SEQ ID NO: 152 and a heavy chain variable region comprising SEQ ID NO: 309; a light chain variable region comprising SEQ ID NO: 153 and a heavy chain variable region comprising SEQ ID NO: 310; a light chain variable region comprising SEQ ID NO: 154 and a heavy chain variable region comprising SEQ ID NO: 311; a light chain variable region comprising SEQ ID NO: 155 and a heavy chain variable region comprising SEQ ID NO: 312; a light chain variable region comprising SEQ ID NO: 156 and a heavy chain variable region comprising SEQ ID NO: 313; and a light chain variable region comprising SEQ ID NO: 157 and a heavy chain variable region comprising SEQ ID NO: 314, wherein the antibody or functional fragment thereof comprises a cysteine or non-canonical amino acid amino acid substitution at one or more conjugation site(s) selected from the group consisting of D70 of the antibody light chain relative to reference sequence SEQ ID NO: 455, E276 of the antibody heavy chain relative to reference sequence SEQ ID NO: 612, and T363 of the antibody heavy chain relative to reference sequence SEQ ID NO: 612.

In one embodiment the antibody or fragment thereof comprises a light chain variable region encoded by a polynucleotide sequence selected from the group consisting of SEQ ID NOs: 1571-1727 and a heavy chain variable region encoded by a polynucleotide sequence selected from the group consisting of SEQ ID NOs: 1728-1884, wherein the antibody or functional fragment thereof comprises a cysteine or non-canonical amino acid amino acid substitution at one or more conjugation site(s) selected from the group consisting of D70 of the antibody light chain relative to reference sequence SEQ ID NO: 455, E276 of the antibody heavy chain relative to reference sequence SEQ ID NO: 612, and T363 of the antibody heavy chain relative to reference sequence SEQ ID NO: 612.

In one embodiment the antibody or fragment thereof comprises a combination of light chain variable region and a heavy chain variable region selected from the group consisting of a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1571 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1728; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1572 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1729; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1573 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1730; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1574 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1731; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1575 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1732; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1576 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1733; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1577 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1734; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1578 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1735; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1579 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1736; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1580 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1737; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1581 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1738; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1582 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1739; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1583 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1740; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1584 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1741; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1585 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1742; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1586 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1743; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1587 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1744; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1588 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1745; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1589 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1746; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1590 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1747; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1591 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1748; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1592 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1749; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1593 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1750; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1594 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1751; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1595 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1752; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1596 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1753; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1597 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1754; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1598 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1755; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1599 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1756; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1600 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1757; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1601 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1758; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1602 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1759; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1603 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1760; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1604 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1761; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1605 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1762; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1606 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1763; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1607 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1764; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1608 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1765; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1609 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1766; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1610 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1767; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1611 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1768; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1612 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1769; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1613 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1770; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1614 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1771; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1615 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1772; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1616 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1773; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1617 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1774; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1618 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1775; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1619 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1776; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1620 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1777; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1621 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1778; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1622 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1779; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1623 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1780; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1624 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1781; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1625 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1782; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1626 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1783; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1627 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1784; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1628 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1785; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1629 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1786; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1630 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1787; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1631 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1788; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1632 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1789; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1633 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1790; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1634 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1791; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1635 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1792; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1636 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1793; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1637 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1794; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1638 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1795; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1639 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1796; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1640 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1797; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1641 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1798; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1642 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1799; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1643 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1800; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1644 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1801; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1645 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1802; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1646 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1803; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1647 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1804; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1648 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1805; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1649 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1806; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1650 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1807; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1651 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1808; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1652 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1809; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1653 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1810; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1654 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1811; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1655 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1812; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1656 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1813; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1657 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1814; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1658 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1815; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1659 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1816; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1660 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1817; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1661 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1818; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1662 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1819; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1663 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1820; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1664 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1821; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1665 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1822; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1666 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1823; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1667 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1824; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1668 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1825; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1669 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1826; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1670 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1827; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1671 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1828; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1672 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1829; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1673 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1830; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1674 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1831; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1675 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1832; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1676 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1833; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1677 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1834; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1678 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1835; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1679 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1836; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1680 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1837; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1681 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1838; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1682 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1839; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1683 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1840; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1684 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1841; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1685 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1842; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1686 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1843; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1687 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1844; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1688 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1845; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1689 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1846; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1690 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1847; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1691 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1848; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1692 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1849; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1693 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1850; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1694 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1851; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1695 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1852; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1696 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1853; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1697 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1854; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1698 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1855; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1699 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1856; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1700 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1857; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1701 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1858; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1702 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1859; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1703 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1860; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1704 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1861; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1705 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1862; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1706 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1863; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1707 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1864; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1708 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1865; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1709 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1866; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1710 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1867; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1711 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1868; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1712 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1869; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1713 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1870; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1714 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1871; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1715 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1872; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1716 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1873; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1717 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1874; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1718 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1875; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1719 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1876; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1720 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1877; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1721 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1878; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1722 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1879; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1723 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1880; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1724 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1881; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1725 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1882; a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1726 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1883; and a light chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1727 and a heavy chain variable region encoded by a polynucleotide sequence comprising SEQ ID NO: 1884, wherein the antibody or functional fragment thereof comprises a cysteine or non-canonical amino acid amino acid substitution at one or more conjugation site(s) selected from the group consisting of D70 of the antibody light chain relative to reference sequence SEQ ID NO: 455, E276 of the antibody heavy chain relative to reference sequence SEQ ID NO: 612, and T363 of the antibody heavy chain relative to reference sequence SEQ ID NO: 612.

The present invention relates to a composition comprising an anti-GIPR antigen binding protein having at least one conjugation site. The conjugation site must be amenable to conjugation of an additional functional moiety (e.g., a GLP-1 receptor agonist) by a defined conjugation chemistry through the side chain of an amino acid residue at the conjugation site. Achieving highly selective, site-specific conjugation to the anti-GIPR antigen binding protein, in accordance with the present invention, requires consideration of a diverse variety of design criteria. First, a preferred conjugation or coupling chemistry must be defined or predetermined. Functional moieties such as, GLP-1 receptor agonists, can be conjugated or coupled to the selected conjugation site of the anti-GIPR antigen binding protein through an assortment of different conjugation chemistries known in the art. For example, a maleimide-activated conjugation partner targeting an accessible cysteine thiol on the anti-GIPR antigen binding protein is one embodiment, but numerous conjugation or coupling chemistries targeting the side chains of either canonical or non-canonical, e.g., unnatural amino acids in the anti-GIPR antigen binding protein sequence, can be employed in accordance with the present invention.

Chemistries for the chemoselective conjugation include: copper(I)-catalyzed azidealkyne [3+2] dipolar cycloadditions, Staudinger ligation, other acyl transfers processes (S→N; X→N), oximations, hydrazone bonding formation and other suitable organic chemistry reactions such as cross-couplings using water-soluble palladium catalysts. (E.g., Bong et al., Chemoselective Pd(0)-catalyzed peptide coupling in water, Organic Letters 3(16):2509-11 (2001); Dibowski et al., Bioconjugation of peptides by palladium-catalyzed C—C cross-coupling in water, Angew. Chem. Int. Ed. 37(4):476-78 (1998); DeVasher et al., Aqueous-phase, palladium-catalyzed cross-coupling of aryl bromides under mild conditions, using water-soluble, sterically demanding alkylphosphines, J. Org. Chem. 69:7919-27 (2004); Shaugnessy et al., J. Org. Chem, 2003, 68, 6767-6774; Prescher, J A and Bertozzi C R, Chemistry in living system, Nature Chemical Biology 1(1); 13-21 (2005)).

As mentioned above, the conjugation (or covalent binding) to the anti-GIPR antigen binding protein is through the side chain of an amino acid residue at the conjugation site, for example, but not limited to, a cysteinyl residue. The amino acid residue, for example, a cysteinyl residue, at the internal conjugation site that is selected can be one that occupies the same amino acid residue position in a native Fc domain sequence, or the amino acid residue can be engineered into the Fc domain sequence by substitution or insertion.

Other examples of unnatural amino acid residues that can be particularly useful as the conjugation site in some embodiments of the inventive processes and compositions of matter include: azido-containing amino acid residues, e.g., azidohomoalanine, p-azido-phenylalanine; keto-containing amino acid residues, e.g., p-acetyl-phenylalanine; alkyne-containing amino acid residues, e.g., p-ethynylphenylalanine, homopropargylglycine, p-(prop-2-ynyl)-tyrosine; alkene-containing amino acid residues e.g., homoallylglycine; aryl halide-containing amino acid residues e.g. p-iodophenylalanine, p-bromophenylalanine; and 1,2-aminothiol containing amino acid residues.

The non-canonical amino acid residues can be incorporated by amino acid substitution or insertion. Non-canonical amino acid residues can be incorporated into the peptide by chemical peptide synthesis rather than by synthesis in biological systems, such as recombinantly expressing cells, or alternatively the skilled artisan can employ known techniques of protein engineering that use recombinantly expressing cells. (See, e.g., Link et al., Non-canonical amino acids in protein engineering, Current Opinion in Biotechnology, 14(6):603-609 (2003); Schultz et al., In vivo incorporation of unnatural amino acids, U.S. Pat. No. 7,045,337).

The selection of the placement of the conjugation site in the overall anti-GIPR antigen binding protein is another important facet of selecting an internal conjugation site in accordance with the present invention. Any of the exposed amino acid residues on the anti-GIPR antigen binding protein can be potentially useful conjugation sites and can be mutated to cysteine or some other reactive amino acid for site-selective coupling, if not already present at the selected conjugation site of the anti-GIPR antigen binding protein sequence. However, this approach does not take into account potential steric constraints that may perturb the activity of the conjugated partner or limit the reactivity of the engineered mutation.

In one embodiment, the anti-GIPR antigen binding protein is an antibody or functional fragment thereof. In one embodiment, the anti-GIPR antibody or functional fragment thereof comprises a cysteine or non-canonical amino acid amino acid substitution at one or more conjugation site(s). The conjugation site(s) can be essentially on any residue of the antigen binding protein. In certain embodiments the conjugation site is located within the CL, CH1, CH₂ or CH3 region of an antibody or functional fragment thereof. In certain embodiments the conjugation site(s) are selected from the group consisting of D70 of the antibody light chain relative to reference sequence SEQ ID NO: 455; E276 of the antibody heavy chain relative to reference sequence SEQ ID NO: 612; and T363 of the antibody heavy chain relative to reference sequence SEQ ID NO: 612. For sake of clarity, “D70 of the antibody light chain relative to reference sequence SEQ ID NO: 455” is the same substitution site as AHo position D88 of the light chain of antibody 5G12.006 and Kabat position D70 of the light chain of antibody 5G12.006; “E276 of the antibody heavy chain relative to reference sequence SEQ ID NO: 612” is the same substitution site as AHo position E384 of the heavy chain of antibody 5G12.006 and Kabat position E285 of the heavy chain of antibody 5G12.006; and “T363 of the antibody heavy chain relative to reference sequence SEQ ID NO: 612” is the same substitution site as AHo position T487 of the heavy chain of antibody 5G12.006 and Kabat position T382 of the heavy chain of antibody 5G12.006.

Some antigen binding proteins comprise a variable light domain and a variable heavy domain as listed in one of the rows for one of the antibodies listed in TABLE 3. In some instances, the antigen binding protein comprises two identical variable light domains and two identical variable heavy domains from one of the antibodies listed in TABLE 3. Some antigen binding proteins that are provided comprise a variable light domain and a variable heavy domain as listed in one of the rows for one of the antibodies listed in TABLE 3, except that one or both of the domains differs from the sequence specified in the table at only 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 or 15 amino acid residues, wherein each such sequence difference is independently either a single amino acid deletion, insertion or substitution, with the deletions, insertions and/or substitutions resulting in no more than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 or 15 amino acid changes relative to the variable domain sequences specified in TABLE 3. In one embodiment, the antigen binding protein comprises a variable region sequence from Table 3, but with the N-terminal methionine deleted. Other antigen binding proteins also comprise a variable light domain and a variable heavy domain as listed in one of the rows for one of the antibodies listed in TABLE 3, except that one or both of the domains differs from the sequence specified in the table in that the heavy chain variable domain and/or light chain variable domain comprises or consists of a sequence of amino acids that has at least 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% sequence identity to the amino acid sequences of the heavy chain variable domain or light chain variable domain sequences as specified in TABLE 3.

In another aspect, the antigen binding protein consists just of a variable light or variable heavy domain from an antibody listed in TABLE 3. In still another aspect, the antigen binding protein comprises two or more of the same variable heavy domains or two or more of the same variable light domains from those listed in TABLE 3. Such domain antibodies can be fused together or joined via a linker as described in greater detail below. The domain antibodies can also be fused or linked to one or more molecules to extend the half-life (e.g., PEG or albumin).

Other antigen binding proteins that are provided are variants of antibodies formed by combination of the heavy and light chains shown in TABLE 3 and comprise light and/or heavy chains that each have at least 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% or 99% identity to the amino acid sequences of these chains. In some instances, such antibodies include at least one heavy chain and one light chain, whereas in other instances the variant forms contain two identical light chains and two identical heavy chains.

The various combinations of heavy chain variable regions may be combined with any of the various combinations of light chain variable regions.

In a further embodiment, the isolated antigen binding protein provided herein is a human antibody comprising a sequence as set forth in TABLE 3 and is of the IgG₁, IgG₂- IgG₃- or IgG₄-type.

The antigen binding proteins disclosed herein are polypeptides into which one or more CDRs are grafted, inserted and/or joined. An antigen binding protein can have 1, 2, 3, 4, 5 or 6 CDRs. An antigen binding protein thus can have, for example, one heavy chain CDR1 (“CDRH1”), and/or one heavy chain CDR2 (“CDRH2”), and/or one heavy chain CDR3 (“CDRH3”), and/or one light chain CDR1 (“CDRL1”), and/or one light chain CDR2 (“CDRL2”), and/or one light chain CDR3 (“CDRL3”). Some antigen binding proteins include both a CDRH3 and a CDRL3. Specific light and heavy chain CDRs are identified in TABLEs 4A and 4B, respectively.

Complementarity determining regions (CDRs) and framework regions (FR) of a given antibody may be identified using the system described by Kabat et al. in Sequences of Proteins of Immunological Interest, 5th Ed., US Dept. of Health and Human Services, PHS, NIH, NIH Publication no. 91-3242, 1991. Certain antibodies that are disclosed herein comprise one or more amino acid sequences that are identical or have substantial sequence identity to the amino acid sequences of one or more of the CDRs presented in TABLES 4A and 4B. These CDRs use the system described by Kabat et al. as noted above.

The structure and properties of CDRs within a naturally occurring antibody has been described, supra. Briefly, in a traditional antibody, the CDRs are embedded within a framework in the heavy and light chain variable region where they constitute the regions responsible for antigen binding and recognition. A variable region comprises at least three heavy or light chain CDRs, see, supra (Kabat et al., 1991, Sequences of Proteins of Immunological Interest, Public Health Service N.I.H., Bethesda, Md.; see also Chothia and Lesk, 1987, J Mol. Biol. 196:901-917; Chothia et al., 1989, Nature 342: 877-883), within a framework region (designated framework regions 1-4, FR1, FR2, FR3, and FR4, by Kabat et al., 1991, supra; see also Chothia and Lesk, 1987, supra). The CDRs provided herein, however, may not only be used to define the antigen binding domain of a traditional antibody structure, but may be embedded in a variety of other polypeptide structures, as described herein.

In one embodiment the antibody or fragment thereof comprises a CDRL1, a CDRL2, a CDRL3, a CDRH1, a CDRH2, and a CDRH3, wherein the antibody or functional fragment thereof comprises a cysteine or non-canonical amino acid amino acid substitution at one or more conjugation site(s) selected from the group consisting of D70 of the antibody light chain relative to reference sequence SEQ ID NO: 455, E276 of the antibody heavy chain relative to reference sequence SEQ ID NO: 612, and T363 of the antibody heavy chain relative to reference sequence SEQ ID NO: 612. In one embodiment the antibody or fragment thereof comprises a CDRL1, a CDRL2, a CDRL3, a CDRH1, a CDRH2, and a CDRH3, wherein each CDRL1, CDRL2, CDRL3, CDRH1, CDRH2, and CDRH3, respectively, comprises a sequence selected from the group consisting of SEQ ID NO: 629, SEQ ID NO: 786, SEQ ID NO: 943, SEQ ID NO: 1100, SEQ ID NO: 1257, and SEQ ID NO: 1414; SEQ ID NO: 630, SEQ ID NO: 787, SEQ ID NO: 944, SEQ ID NO: 1101, SEQ ID NO: 1258, and SEQ ID NO: 1415; SEQ ID NO: 631, SEQ ID NO: 788, SEQ ID NO: 945, SEQ ID NO: 1102, SEQ ID NO: 1259, and SEQ ID NO: 1416; SEQ ID NO: 632, SEQ ID NO: 789, SEQ ID NO: 946, SEQ ID NO: 1103, SEQ ID NO: 1260, and SEQ ID NO: 1417; SEQ ID NO: 633, SEQ ID NO: 790, SEQ ID NO: 947, SEQ ID NO: 1104, SEQ ID NO: 1261, and SEQ ID NO: 1418; SEQ ID NO: 634, SEQ ID NO: 791, SEQ ID NO: 948, SEQ ID NO: 1105, SEQ ID NO: 1262, and SEQ ID NO: 1419; SEQ ID NO: 635, SEQ ID NO: 792, SEQ ID NO: 949, SEQ ID NO: 1106, SEQ ID NO: 1263, and SEQ ID NO: 1420; SEQ ID NO: 636, SEQ ID NO: 793, SEQ ID NO: 950, SEQ ID NO: 1107, SEQ ID NO: 1264, and SEQ ID NO: 1421; SEQ ID NO: 637, SEQ ID NO: 794, SEQ ID NO: 951, SEQ ID NO: 1108, SEQ ID NO: 1265, and SEQ ID NO: 1422; SEQ ID NO: 638, SEQ ID NO: 795, SEQ ID NO: 952, SEQ ID NO: 1109, SEQ ID NO: 1266, and SEQ ID NO: 1423; SEQ ID NO: 639, SEQ ID NO: 796, SEQ ID NO: 953, SEQ ID NO: 1110, SEQ ID NO: 1267, and SEQ ID NO: 1424; SEQ ID NO: 640, SEQ ID NO: 797, SEQ ID NO: 954, SEQ ID NO: 1111, SEQ ID NO: 1268, and SEQ ID NO: 1425; SEQ ID NO: 641, SEQ ID NO: 798, SEQ ID NO: 955, SEQ ID NO: 1112, SEQ ID NO: 1269, and SEQ ID NO: 1426; SEQ ID NO: 642, SEQ ID NO: 799, SEQ ID NO: 956, SEQ ID NO: 1113, SEQ ID NO: 1270, and SEQ ID NO: 1427; SEQ ID NO: 643, SEQ ID NO: 800, SEQ ID NO: 957, SEQ ID NO: 1114, SEQ ID NO: 1271, and SEQ ID NO: 1428; SEQ ID NO: 644, SEQ ID NO: 801, SEQ ID NO: 958, SEQ ID NO: 1115, SEQ ID NO: 1272, and SEQ ID NO: 1429; SEQ ID NO: 645, SEQ ID NO: 802, SEQ ID NO: 959, SEQ ID NO: 1116, SEQ ID NO: 1273, and SEQ ID NO: 1430; SEQ ID NO: 646, SEQ ID NO: 803, SEQ ID NO: 960, SEQ ID NO: 1117, SEQ ID NO: 1274, and SEQ ID NO: 1431; SEQ ID NO: 647, SEQ ID NO: 804, SEQ ID NO: 961, SEQ ID NO: 1118, SEQ ID NO: 1275, and SEQ ID NO: 1432; SEQ ID NO: 648, SEQ ID NO: 805, SEQ ID NO: 962, SEQ ID NO: 1119, SEQ ID NO: 1276, and SEQ ID NO: 1433; SEQ ID NO: 649, SEQ ID NO: 806, SEQ ID NO: 963, SEQ ID NO: 1120, SEQ ID NO: 1277, and SEQ ID NO: 1434; SEQ ID NO: 650, SEQ ID NO: 807, SEQ ID NO: 964, SEQ ID NO: 1121, SEQ ID NO: 1278, and SEQ ID NO: 1435; SEQ ID NO: 651, SEQ ID NO: 808, SEQ ID NO: 965, SEQ ID NO: 1122, SEQ ID NO: 1279, and SEQ ID NO: 1436; SEQ ID NO: 652, SEQ ID NO: 809, SEQ ID NO: 966, SEQ ID NO: 1123, SEQ ID NO: 1280, and SEQ ID NO: 1437; SEQ ID NO: 653, SEQ ID NO: 810, SEQ ID NO: 967, SEQ ID NO: 1124, SEQ ID NO: 1281, and SEQ ID NO: 1438; SEQ ID NO: 654, SEQ ID NO: 811, SEQ ID NO: 968, SEQ ID NO: 1125, SEQ ID NO: 1282, and SEQ ID NO: 1439; SEQ ID NO: 655, SEQ ID NO: 812, SEQ ID NO: 969, SEQ ID NO: 1126, SEQ ID NO: 1283, and SEQ ID NO: 1440; SEQ ID NO: 656, SEQ ID NO: 813, SEQ ID NO: 970, SEQ ID NO: 1127, SEQ ID NO: 1284, and SEQ ID NO: 1441; SEQ ID NO: 657, SEQ ID NO: 814, SEQ ID NO: 971, SEQ ID NO: 1128, SEQ ID NO: 1285, and SEQ ID NO: 1442; SEQ ID NO: 658, SEQ ID NO: 815, SEQ ID NO: 972, SEQ ID NO: 1129, SEQ ID NO: 1286, and SEQ ID NO: 1443; SEQ ID NO: 659, SEQ ID NO: 816, SEQ ID NO: 973, SEQ ID NO: 1130, SEQ ID NO: 1287, and SEQ ID NO: 1444; SEQ ID NO: 660, SEQ ID NO: 817, SEQ ID NO: 974, SEQ ID NO: 1131, SEQ ID NO: 1288, and SEQ ID NO: 1445; SEQ ID NO: 661, SEQ ID NO: 818, SEQ ID NO: 975, SEQ ID NO: 1132, SEQ ID NO: 1289, and SEQ ID NO: 1446; SEQ ID NO: 662, SEQ ID NO: 819, SEQ ID NO: 976, SEQ ID NO: 1133, SEQ ID NO: 1290, and SEQ ID NO: 1447; SEQ ID NO: 663, SEQ ID NO: 820, SEQ ID NO: 977, SEQ ID NO: 1134, SEQ ID NO: 1291, and SEQ ID NO: 1448; SEQ ID NO: 664, SEQ ID NO: 821, SEQ ID NO: 978, SEQ ID NO: 1135, SEQ ID NO: 1292, and SEQ ID NO: 1449; SEQ ID NO: 665, SEQ ID NO: 822, SEQ ID NO: 979, SEQ ID NO: 1136, SEQ ID NO: 1293, and SEQ ID NO: 1450; SEQ ID NO: 666, SEQ ID NO: 823, SEQ ID NO: 980, SEQ ID NO: 1137, SEQ ID NO: 1294, and SEQ ID NO: 1451; SEQ ID NO: 667, SEQ ID NO: 824, SEQ ID NO: 981, SEQ ID NO: 1138, SEQ ID NO: 1295, and SEQ ID NO: 1452; SEQ ID NO: 668, SEQ ID NO: 825, SEQ ID NO: 982, SEQ ID NO: 1139, SEQ ID NO: 1296, and SEQ ID NO: 1453; SEQ ID NO: 669, SEQ ID NO: 826, SEQ ID NO: 983, SEQ ID NO: 1140, SEQ ID NO: 1297, and SEQ ID NO: 1454; SEQ ID NO: 670, SEQ ID NO: 827, SEQ ID NO: 984, SEQ ID NO: 1141, SEQ ID NO: 1298, and SEQ ID NO: 1455; SEQ ID NO: 671, SEQ ID NO: 828, SEQ ID NO: 985, SEQ ID NO: 1142, SEQ ID NO: 1299, and SEQ ID NO: 1456; SEQ ID NO: 672, SEQ ID NO: 829, SEQ ID NO: 986, SEQ ID NO: 1143, SEQ ID NO: 1300, and SEQ ID NO: 1457; SEQ ID NO: 673, SEQ ID NO: 830, SEQ ID NO: 987, SEQ ID NO: 1144, SEQ ID NO: 1301, and SEQ ID NO: 1458; SEQ ID NO: 674, SEQ ID NO: 831, SEQ ID NO: 988, SEQ ID NO: 1145, SEQ ID NO: 1302, and SEQ ID NO: 1459; SEQ ID NO: 675, SEQ ID NO: 832, SEQ ID NO: 989, SEQ ID NO: 1146, SEQ ID NO: 1303, and SEQ ID NO: 1460; SEQ ID NO: 676, SEQ ID NO: 833, SEQ ID NO: 990, SEQ ID NO: 1147, SEQ ID NO: 1304, and SEQ ID NO: 1461; SEQ ID NO: 677, SEQ ID NO: 834, SEQ ID NO: 991, SEQ ID NO: 1148, SEQ ID NO: 1305, and SEQ ID NO: 1462; SEQ ID NO: 678, SEQ ID NO: 835, SEQ ID NO: 992, SEQ ID NO: 1149, SEQ ID NO: 1306, and SEQ ID NO: 1463; SEQ ID NO: 679, SEQ ID NO: 836, SEQ ID NO: 993, SEQ ID NO: 1150, SEQ ID NO: 1307, and SEQ ID NO: 1464; SEQ ID NO: 680, SEQ ID NO: 837, SEQ ID NO: 994, SEQ ID NO: 1151, SEQ ID NO: 1308, and SEQ ID NO: 1465; SEQ ID NO: 681, SEQ ID NO: 838, SEQ ID NO: 995, SEQ ID NO: 1152, SEQ ID NO: 1309, and SEQ ID NO: 1466; SEQ ID NO: 682, SEQ ID NO: 839, SEQ ID NO: 996, SEQ ID NO: 1153, SEQ ID NO: 1310, and SEQ ID NO: 1467; SEQ ID NO: 683, SEQ ID NO: 840, SEQ ID NO: 997, SEQ ID NO: 1154, SEQ ID NO: 1311, and SEQ ID NO: 1468; SEQ ID NO: 684, SEQ ID NO: 841, SEQ ID NO: 998, SEQ ID NO: 1155, SEQ ID NO: 1312, and SEQ ID NO: 1469; SEQ ID NO: 685, SEQ ID NO: 842, SEQ ID NO: 999, SEQ ID NO: 1156, SEQ ID NO: 1313, and SEQ ID NO: 1470; SEQ ID NO: 686, SEQ ID NO: 843, SEQ ID NO: 1000, SEQ ID NO: 1157, SEQ ID NO: 1314, and SEQ ID NO: 1471; SEQ ID NO: 687, SEQ ID NO: 844, SEQ ID NO: 1001, SEQ ID NO: 1158, SEQ ID NO: 1315, and SEQ ID NO: 1472; SEQ ID NO: 688, SEQ ID NO: 845, SEQ ID NO: 1002, SEQ ID NO: 1159, SEQ ID NO: 1316, and SEQ ID NO: 1473; SEQ ID NO: 689, SEQ ID NO: 846, SEQ ID NO: 1003, SEQ ID NO: 1160, SEQ ID NO: 1317, and SEQ ID NO: 1474; SEQ ID NO: 690, SEQ ID NO: 847, SEQ ID NO: 1004, SEQ ID NO: 1161, SEQ ID NO: 1318, and SEQ ID NO: 1475; SEQ ID NO: 691, SEQ ID NO: 848, SEQ ID NO: 1005, SEQ ID NO: 1162, SEQ ID NO: 1319, and SEQ ID NO: 1476; SEQ ID NO: 692, SEQ ID NO: 849, SEQ ID NO: 1006, SEQ ID NO: 1163, SEQ ID NO: 1320, and SEQ ID NO: 1477; SEQ ID NO: 693, SEQ ID NO: 850, SEQ ID NO: 1007, SEQ ID NO: 1164, SEQ ID NO: 1321, and SEQ ID NO: 1478; SEQ ID NO: 694, SEQ ID NO: 851, SEQ ID NO: 1008, SEQ ID NO: 1165, SEQ ID NO: 1322, and SEQ ID NO: 1479; SEQ ID NO: 695, SEQ ID NO: 852, SEQ ID NO: 1009, SEQ ID NO: 1166, SEQ ID NO: 1323, and SEQ ID NO: 1480; SEQ ID NO: 696, SEQ ID NO: 853, SEQ ID NO: 1010, SEQ ID NO: 1167, SEQ ID NO: 1324, and SEQ ID NO: 1481; SEQ ID NO: 697, SEQ ID NO: 854, SEQ ID NO: 1011, SEQ ID NO: 1168, SEQ ID NO: 1325, and SEQ ID NO: 1482; SEQ ID NO: 698, SEQ ID NO: 855, SEQ ID NO: 1012, SEQ ID NO: 1169, SEQ ID NO: 1326, and SEQ ID NO: 1483; SEQ ID NO: 699, SEQ ID NO: 856, SEQ ID NO: 1013, SEQ ID NO: 1170, SEQ ID NO: 1327, and SEQ ID NO: 1484; SEQ ID NO: 700, SEQ ID NO: 857, SEQ ID NO: 1014, SEQ ID NO: 1171, SEQ ID NO: 1328, and SEQ ID NO: 1485; SEQ ID NO: 701, SEQ ID NO: 858, SEQ ID NO: 1015, SEQ ID NO: 1172, SEQ ID NO: 1329, and SEQ ID NO: 1486; SEQ ID NO: 702, SEQ ID NO: 859, SEQ ID NO: 1016, SEQ ID NO: 1173, SEQ ID NO: 1330, and SEQ ID NO: 1487; SEQ ID NO: 703, SEQ ID NO: 860, SEQ ID NO: 1017, SEQ ID NO: 1174, SEQ ID NO: 1331, and SEQ ID NO: 1488; SEQ ID NO: 704, SEQ ID NO: 861, SEQ ID NO: 1018, SEQ ID NO: 1175, SEQ ID NO: 1332, and SEQ ID NO: 1489; SEQ ID NO: 705, SEQ ID NO: 862, SEQ ID NO: 1019, SEQ ID NO: 1176, SEQ ID NO: 1333, and SEQ ID NO: 1490; SEQ ID NO: 706, SEQ ID NO: 863, SEQ ID NO: 1020, SEQ ID NO: 1177, SEQ ID NO: 1334, and SEQ ID NO: 1491; SEQ ID NO: 707, SEQ ID NO: 864, SEQ ID NO: 1021, SEQ ID NO: 1178, SEQ ID NO: 1335, and SEQ ID NO: 1492; SEQ ID NO: 708, SEQ ID NO: 865, SEQ ID NO: 1022, SEQ ID NO: 1179, SEQ ID NO: 1336, and SEQ ID NO: 1493; SEQ ID NO: 709, SEQ ID NO: 866, SEQ ID NO: 1023, SEQ ID NO: 1180, SEQ ID NO: 1337, and SEQ ID NO: 1494; SEQ ID NO: 710, SEQ ID NO: 867, SEQ ID NO: 1024, SEQ ID NO: 1181, SEQ ID NO: 1338, and SEQ ID NO: 1495; SEQ ID NO: 711, SEQ ID NO: 868, SEQ ID NO: 1025, SEQ ID NO: 1182, SEQ ID NO: 1339, and SEQ ID NO: 1496; SEQ ID NO: 712, SEQ ID NO: 869, SEQ ID NO: 1026, SEQ ID NO: 1183, SEQ ID NO: 1340, and SEQ ID NO: 1497; SEQ ID NO: 713, SEQ ID NO: 870, SEQ ID NO: 1027, SEQ ID NO: 1184, SEQ ID NO: 1341, and SEQ ID NO: 1498; SEQ ID NO: 714, SEQ ID NO: 871, SEQ ID NO: 1028, SEQ ID NO: 1185, SEQ ID NO: 1342, and SEQ ID NO: 1499; SEQ ID NO: 715, SEQ ID NO: 872, SEQ ID NO: 1029, SEQ ID NO: 1186, SEQ ID NO: 1343, and SEQ ID NO: 1500; SEQ ID NO: 716, SEQ ID NO: 873, SEQ ID NO: 1030, SEQ ID NO: 1187, SEQ ID NO: 1344, and SEQ ID NO: 1501; SEQ ID NO: 717, SEQ ID NO: 874, SEQ ID NO: 1031, SEQ ID NO: 1188, SEQ ID NO: 1345, and SEQ ID NO: 1502; SEQ ID NO: 718, SEQ ID NO: 875, SEQ ID NO: 1032, SEQ ID NO: 1189, SEQ ID NO: 1346, and SEQ ID NO: 1503; SEQ ID NO: 719, SEQ ID NO: 876, SEQ ID NO: 1033, SEQ ID NO: 1190, SEQ ID NO: 1347, and SEQ ID NO: 1504; SEQ ID NO: 720, SEQ ID NO: 877, SEQ ID NO: 1034, SEQ ID NO: 1191, SEQ ID NO: 1348, and SEQ ID NO: 1505; SEQ ID NO: 721, SEQ ID NO: 878, SEQ ID NO: 1035, SEQ ID NO: 1192, SEQ ID NO: 1349, and SEQ ID NO: 1506; SEQ ID NO: 722, SEQ ID NO: 879, SEQ ID NO: 1036, SEQ ID NO: 1193, SEQ ID NO: 1350, and SEQ ID NO: 1507; SEQ ID NO: 723, SEQ ID NO: 880, SEQ ID NO: 1037, SEQ ID NO: 1194, SEQ ID NO: 1351, and SEQ ID NO: 1508; SEQ ID NO: 724, SEQ ID NO: 881, SEQ ID NO: 1038, SEQ ID NO: 1195, SEQ ID NO: 1352, and SEQ ID NO: 1509; SEQ ID NO: 725, SEQ ID NO: 882, SEQ ID NO: 1039, SEQ ID NO: 1196, SEQ ID NO: 1353, and SEQ ID NO: 1510; SEQ ID NO: 726, SEQ ID NO: 883, SEQ ID NO: 1040, SEQ ID NO: 1197, SEQ ID NO: 1354, and SEQ ID NO: 1511; SEQ ID NO: 727, SEQ ID NO: 884, SEQ ID NO: 1041, SEQ ID NO: 1198, SEQ ID NO: 1355, and SEQ ID NO: 1512; SEQ ID NO: 728, SEQ ID NO: 885, SEQ ID NO: 1042, SEQ ID NO: 1199, SEQ ID NO: 1356, and SEQ ID NO: 1513; SEQ ID NO: 729, SEQ ID NO: 886, SEQ ID NO: 1043, SEQ ID NO: 1200, SEQ ID NO: 1357, and SEQ ID NO: 1514; SEQ ID NO: 730, SEQ ID NO: 887, SEQ ID NO: 1044, SEQ ID NO: 1201, SEQ ID NO: 1358, and SEQ ID NO: 1515; SEQ ID NO: 731, SEQ ID NO: 888, SEQ ID NO: 1045, SEQ ID NO: 1202, SEQ ID NO: 1359, and SEQ ID NO: 1516; SEQ ID NO: 732, SEQ ID NO: 889, SEQ ID NO: 1046, SEQ ID NO: 1203, SEQ ID NO: 1360, and SEQ ID NO: 1517; SEQ ID NO: 733, SEQ ID NO: 890, SEQ ID NO: 1047, SEQ ID NO: 1204, SEQ ID NO: 1361, and SEQ ID NO: 1518; SEQ ID NO: 734, SEQ ID NO: 891, SEQ ID NO: 1048, SEQ ID NO: 1205, SEQ ID NO: 1362, and SEQ ID NO: 1519; SEQ ID NO: 735, SEQ ID NO: 892, SEQ ID NO: 1049, SEQ ID NO: 1206, SEQ ID NO: 1363, and SEQ ID NO: 1520; SEQ ID NO: 736, SEQ ID NO: 893, SEQ ID NO: 1050, SEQ ID NO: 1207, SEQ ID NO: 1364, and SEQ ID NO: 1521; SEQ ID NO: 737, SEQ ID NO: 894, SEQ ID NO: 1051, SEQ ID NO: 1208, SEQ ID NO: 1365, and SEQ ID NO: 1522; SEQ ID NO: 738, SEQ ID NO: 895, SEQ ID NO: 1052, SEQ ID NO: 1209, SEQ ID NO: 1366, and SEQ ID NO: 1523; SEQ ID NO: 739, SEQ ID NO: 896, SEQ ID NO: 1053, SEQ ID NO: 1210, SEQ ID NO: 1367, and SEQ ID NO: 1524; SEQ ID NO: 740, SEQ ID NO: 897, SEQ ID NO: 1054, SEQ ID NO: 1211, SEQ ID NO: 1368, and SEQ ID NO: 1525; SEQ ID NO: 741, SEQ ID NO: 898, SEQ ID NO: 1055, SEQ ID NO: 1212, SEQ ID NO: 1369, and SEQ ID NO: 1526; SEQ ID NO: 742, SEQ ID NO: 899, SEQ ID NO: 1056, SEQ ID NO: 1213, SEQ ID NO: 1370, and SEQ ID NO: 1527; SEQ ID NO: 743, SEQ ID NO: 900, SEQ ID NO: 1057, SEQ ID NO: 1214, SEQ ID NO: 1371, and SEQ ID NO: 1528; SEQ ID NO: 744, SEQ ID NO: 901, SEQ ID NO: 1058, SEQ ID NO: 1215, SEQ ID NO: 1372, and SEQ ID NO: 1529; SEQ ID NO: 745, SEQ ID NO: 902, SEQ ID NO: 1059, SEQ ID NO: 1216, SEQ ID NO: 1373, and SEQ ID NO: 1530; SEQ ID NO: 746, SEQ ID NO: 903, SEQ ID NO: 1060, SEQ ID NO: 1217, SEQ ID NO: 1374, and SEQ ID NO: 1531; SEQ ID NO: 747, SEQ ID NO: 904, SEQ ID NO: 1061, SEQ ID NO: 1218, SEQ ID NO: 1375, and SEQ ID NO: 1532; SEQ ID NO: 748, SEQ ID NO: 905, SEQ ID NO: 1062, SEQ ID NO: 1219, SEQ ID NO: 1376, and SEQ ID NO: 1533; SEQ ID NO: 749, SEQ ID NO: 906, SEQ ID NO: 1063, SEQ ID NO: 1220, SEQ ID NO: 1377, and SEQ ID NO: 1534; SEQ ID NO: 750, SEQ ID NO: 907, SEQ ID NO: 1064, SEQ ID NO: 1221, SEQ ID NO: 1378, and SEQ ID NO: 1535; SEQ ID NO: 751, SEQ ID NO: 908, SEQ ID NO: 1065, SEQ ID NO: 1222, SEQ ID NO: 1379, and SEQ ID NO: 1536; SEQ ID NO: 752, SEQ ID NO: 909, SEQ ID NO: 1066, SEQ ID NO: 1223, SEQ ID NO: 1380, and SEQ ID NO: 1537; SEQ ID NO: 753, SEQ ID NO: 910, SEQ ID NO: 1067, SEQ ID NO: 1224, SEQ ID NO: 1381, and SEQ ID NO: 1538; SEQ ID NO: 754, SEQ ID NO: 911, SEQ ID NO: 1068, SEQ ID NO: 1225, SEQ ID NO: 1382, and SEQ ID NO: 1539; SEQ ID NO: 755, SEQ ID NO: 912, SEQ ID NO: 1069, SEQ ID NO: 1226, SEQ ID NO: 1383, and SEQ ID NO: 1540; SEQ ID NO: 756, SEQ ID NO: 913, SEQ ID NO: 1070, SEQ ID NO: 1227, SEQ ID NO: 1384, and SEQ ID NO: 1541; SEQ ID NO: 757, SEQ ID NO: 914, SEQ ID NO: 1071, SEQ ID NO: 1228, SEQ ID NO: 1385, and SEQ ID NO: 1542; SEQ ID NO: 758, SEQ ID NO: 915, SEQ ID NO: 1072, SEQ ID NO: 1229, SEQ ID NO: 1386, and SEQ ID NO: 1543; SEQ ID NO: 759, SEQ ID NO: 916, SEQ ID NO: 1073, SEQ ID NO: 1230, SEQ ID NO: 1387, and SEQ ID NO: 1544; SEQ ID NO: 760, SEQ ID NO: 917, SEQ ID NO: 1074, SEQ ID NO: 1231, SEQ ID NO: 1388, and SEQ ID NO: 1545; SEQ ID NO: 761, SEQ ID NO: 918, SEQ ID NO: 1075, SEQ ID NO: 1232, SEQ ID NO: 1389, and SEQ ID NO: 1546; SEQ ID NO: 762, SEQ ID NO: 919, SEQ ID NO: 1076, SEQ ID NO: 1233, SEQ ID NO: 1390, and SEQ ID NO: 1547; SEQ ID NO: 763, SEQ ID NO: 920, SEQ ID NO: 1077, SEQ ID NO: 1234, SEQ ID NO: 1391, and SEQ ID NO: 1548; SEQ ID NO: 764, SEQ ID NO: 921, SEQ ID NO: 1078, SEQ ID NO: 1235, SEQ ID NO: 1392, and SEQ ID NO: 1549; SEQ ID NO: 765, SEQ ID NO: 922, SEQ ID NO: 1079, SEQ ID NO: 1236, SEQ ID NO: 1393, and SEQ ID NO: 1550; SEQ ID NO: 766, SEQ ID NO: 923, SEQ ID NO: 1080, SEQ ID NO: 1237, SEQ ID NO: 1394, and SEQ ID NO: 1551; SEQ ID NO: 767, SEQ ID NO: 924, SEQ ID NO: 1081, SEQ ID NO: 1238, SEQ ID NO: 1395, and SEQ ID NO: 1552; SEQ ID NO: 768, SEQ ID NO: 925, SEQ ID NO: 1082, SEQ ID NO: 1239, SEQ ID NO: 1396, and SEQ ID NO: 1553; SEQ ID NO: 769, SEQ ID NO: 926, SEQ ID NO: 1083, SEQ ID NO: 1240, SEQ ID NO: 1397, and SEQ ID NO: 1554; SEQ ID NO: 770, SEQ ID NO: 927, SEQ ID NO: 1084, SEQ ID NO: 1241, SEQ ID NO: 1398, and SEQ ID NO: 1555; SEQ ID NO: 771, SEQ ID NO: 928, SEQ ID NO: 1085, SEQ ID NO: 1242, SEQ ID NO: 1399, and SEQ ID NO: 1556; SEQ ID NO: 772, SEQ ID NO: 929, SEQ ID NO: 1086, SEQ ID NO: 1243, SEQ ID NO: 1400, and SEQ ID NO: 1557; SEQ ID NO: 773, SEQ ID NO: 930, SEQ ID NO: 1087, SEQ ID NO: 1244, SEQ ID NO: 1401, and SEQ ID NO: 1558; SEQ ID NO: 774, SEQ ID NO: 931, SEQ ID NO: 1088, SEQ ID NO: 1245, SEQ ID NO: 1402, and SEQ ID NO: 1559; SEQ ID NO: 775, SEQ ID NO: 932, SEQ ID NO: 1089, SEQ ID NO: 1246, SEQ ID NO: 1403, and SEQ ID NO: 1560; SEQ ID NO: 776, SEQ ID NO: 933, SEQ ID NO: 1090, SEQ ID NO: 1247, SEQ ID NO: 1404, and SEQ ID NO: 1561; SEQ ID NO: 777, SEQ ID NO: 934, SEQ ID NO: 1091, SEQ ID NO: 1248, SEQ ID NO: 1405, and SEQ ID NO: 1562; SEQ ID NO: 778, SEQ ID NO: 935, SEQ ID NO: 1092, SEQ ID NO: 1249, SEQ ID NO: 1406, and SEQ ID NO: 1563; SEQ ID NO: 779, SEQ ID NO: 936, SEQ ID NO: 1093, SEQ ID NO: 1250, SEQ ID NO: 1407, and SEQ ID NO: 1564; SEQ ID NO: 780, SEQ ID NO: 937, SEQ ID NO: 1094, SEQ ID NO: 1251, SEQ ID NO: 1408, and SEQ ID NO: 1565; SEQ ID NO: 781, SEQ ID NO: 938, SEQ ID NO: 1095, SEQ ID NO: 1252, SEQ ID NO: 1409, and SEQ ID NO: 1566; SEQ ID NO: 782, SEQ ID NO: 939, SEQ ID NO: 1096, SEQ ID NO: 1253, SEQ ID NO: 1410, and SEQ ID NO: 1567; SEQ ID NO: 783, SEQ ID NO: 940, SEQ ID NO: 1097, SEQ ID NO: 1254, SEQ ID NO: 1411, and SEQ ID NO: 1568; SEQ ID NO: 784, SEQ ID NO: 941, SEQ ID NO: 1098, SEQ ID NO: 1255, SEQ ID NO: 1412, and SEQ ID NO: 1569; and SEQ ID NO: 785, SEQ ID NO: 942, SEQ ID NO: 1099, SEQ ID NO: 1256, SEQ ID NO: 1413, and SEQ ID NO: 1570, wherein the antibody or functional fragment thereof comprises a cysteine or non-canonical amino acid amino acid substitution at one or more conjugation site(s) selected from the group consisting of D70 of the antibody light chain relative to reference sequence SEQ ID NO: 455, E276 of the antibody heavy chain relative to reference sequence SEQ ID NO: 612, and T363 of the antibody heavy chain relative to reference sequence SEQ ID NO: 612.

In one embodiment the antibody or fragment thereof comprises a CDRL1, a CDRL2, a CDRL3, a CDRH1, a CDRH2, and a CDRH3, wherein the antibody or functional fragment thereof comprises a cysteine or non-canonical amino acid amino acid substitution at one or more conjugation site(s) selected from the group consisting of D70 of the antibody light chain relative to reference sequence SEQ ID NO: 455, E276 of the antibody heavy chain relative to reference sequence SEQ ID NO: 612, and T363 of the antibody heavy chain relative to reference sequence SEQ ID NO: 612, encoded by a polynucleotide. In one embodiment the antibody or fragment thereof comprises a CDRL1, a CDRL2, a CDRL3, a CDRH1, a CDRH2, and a CDRH3, wherein the antibody or functional fragment thereof comprises a cysteine or non-canonical amino acid amino acid substitution at one or more conjugation site(s) selected from the group consisting of D70 of the antibody light chain relative to reference sequence SEQ ID NO: 455, E276 of the antibody heavy chain relative to reference sequence SEQ ID NO: 612, and T363 of the antibody heavy chain relative to reference sequence SEQ ID NO: 612, wherein each CDRL1, CDRL2, CDRL3, CDRH1, CDRH2, and CDRH3, respectively, is encoded by a sequence selected from the group consisting of SEQ ID NO: 2199, SEQ ID NO: 2356, SEQ ID NO: 2513, SEQ ID NO: 2670, SEQ ID NO: 2827, and SEQ ID NO: 2984; SEQ ID NO: 2200, SEQ ID NO: 2357, SEQ ID NO: 2514, SEQ ID NO: 2671, SEQ ID NO: 2828, and SEQ ID NO: 2985; SEQ ID NO: 2201, SEQ ID NO: 2358, SEQ ID NO: 2515, SEQ ID NO: 2672, SEQ ID NO: 2829, and SEQ ID NO: 2986; SEQ ID NO: 2202, SEQ ID NO: 2359, SEQ ID NO: 2516, SEQ ID NO: 2673, SEQ ID NO: 2830, and SEQ ID NO: 2987; SEQ ID NO: 2203, SEQ ID NO: 2360, SEQ ID NO: 2517, SEQ ID NO: 2674, SEQ ID NO: 2831, and SEQ ID NO: 2988; SEQ ID NO: 2204, SEQ ID NO: 2361, SEQ ID NO: 2518, SEQ ID NO: 2675, SEQ ID NO: 2832, and SEQ ID NO: 2989; SEQ ID NO: 2205, SEQ ID NO: 2362, SEQ ID NO: 2519, SEQ ID NO: 2676, SEQ ID NO: 2833, and SEQ ID NO: 2990; SEQ ID NO: 2206, SEQ ID NO: 2363, SEQ ID NO: 2520, SEQ ID NO: 2677, SEQ ID NO: 2834, and SEQ ID NO: 2991; SEQ ID NO: 2207, SEQ ID NO: 2364, SEQ ID NO: 2521, SEQ ID NO: 2678, SEQ ID NO: 2835, and SEQ ID NO: 2992; SEQ ID NO: 2208, SEQ ID NO: 2365, SEQ ID NO: 2522, SEQ ID NO: 2679, SEQ ID NO: 2836, and SEQ ID NO: 2993; SEQ ID NO: 2209, SEQ ID NO: 2366, SEQ ID NO: 2523, SEQ ID NO: 2680, SEQ ID NO: 2837, and SEQ ID NO: 2994; SEQ ID NO: 2210, SEQ ID NO: 2367, SEQ ID NO: 2524, SEQ ID NO: 2681, SEQ ID NO: 2838, and SEQ ID NO: 2995; SEQ ID NO: 2211, SEQ ID NO: 2368, SEQ ID NO: 2525, SEQ ID NO: 2682, SEQ ID NO: 2839, and SEQ ID NO: 2996; SEQ ID NO: 2212, SEQ ID NO: 2369, SEQ ID NO: 2526, SEQ ID NO: 2683, SEQ ID NO: 2840, and SEQ ID NO: 2997; SEQ ID NO: 2213, SEQ ID NO: 2370, SEQ ID NO: 2527, SEQ ID NO: 2684, SEQ ID NO: 2841, and SEQ ID NO: 2998; SEQ ID NO: 2214, SEQ ID NO: 2371, SEQ ID NO: 2528, SEQ ID NO: 2685, SEQ ID NO: 2842, and SEQ ID NO: 2999; SEQ ID NO: 2215, SEQ ID NO: 2372, SEQ ID NO: 2529, SEQ ID NO: 2686, SEQ ID NO: 2843, and SEQ ID NO: 3000; SEQ ID NO: 2216, SEQ ID NO: 2373, SEQ ID NO: 2530, SEQ ID NO: 2687, SEQ ID NO: 2844, and SEQ ID NO: 3001; SEQ ID NO: 2217, SEQ ID NO: 2374, SEQ ID NO: 2531, SEQ ID NO: 2688, SEQ ID NO: 2845, and SEQ ID NO: 3002; SEQ ID NO: 2218, SEQ ID NO: 2375, SEQ ID NO: 2532, SEQ ID NO: 2689, SEQ ID NO: 2846, and SEQ ID NO: 3003; SEQ ID NO: 2219, SEQ ID NO: 2376, SEQ ID NO: 2533, SEQ ID NO: 2690, SEQ ID NO: 2847, and SEQ ID NO: 3004; SEQ ID NO: 2220, SEQ ID NO: 2377, SEQ ID NO: 2534, SEQ ID NO: 2691, SEQ ID NO: 2848, and SEQ ID NO: 3005; SEQ ID NO: 2221, SEQ ID NO: 2378, SEQ ID NO: 2535, SEQ ID NO: 2692, SEQ ID NO: 2849, and SEQ ID NO: 3006; SEQ ID NO: 2222, SEQ ID NO: 2379, SEQ ID NO: 2536, SEQ ID NO: 2693, SEQ ID NO: 2850, and SEQ ID NO: 3007; SEQ ID NO: 2223, SEQ ID NO: 2380, SEQ ID NO: 2537, SEQ ID NO: 2694, SEQ ID NO: 2851, and SEQ ID NO: 3008; SEQ ID NO: 2224, SEQ ID NO: 2381, SEQ ID NO: 2538, SEQ ID NO: 2695, SEQ ID NO: 2852, and SEQ ID NO: 3009; SEQ ID NO: 2225, SEQ ID NO: 2382, SEQ ID NO: 2539, SEQ ID NO: 2696, SEQ ID NO: 2853, and SEQ ID NO: 3010; SEQ ID NO: 2226, SEQ ID NO: 2383, SEQ ID NO: 2540, SEQ ID NO: 2697, SEQ ID NO: 2854, and SEQ ID NO: 3011; SEQ ID NO: 2227, SEQ ID NO: 2384, SEQ ID NO: 2541, SEQ ID NO: 2698, SEQ ID NO: 2855, and SEQ ID NO: 3012; SEQ ID NO: 2228, SEQ ID NO: 2385, SEQ ID NO: 2542, SEQ ID NO: 2699, SEQ ID NO: 2856, and SEQ ID NO: 3013; SEQ ID NO: 2229, SEQ ID NO: 2386, SEQ ID NO: 2543, SEQ ID NO: 2700, SEQ ID NO: 2857, and SEQ ID NO: 3014; SEQ ID NO: 2230, SEQ ID NO: 2387, SEQ ID NO: 2544, SEQ ID NO: 2701, SEQ ID NO: 2858, and SEQ ID NO: 3015; SEQ ID NO: 2231, SEQ ID NO: 2388, SEQ ID NO: 2545, SEQ ID NO: 2702, SEQ ID NO: 2859, and SEQ ID NO: 3016; SEQ ID NO: 2232, SEQ ID NO: 2389, SEQ ID NO: 2546, SEQ ID NO: 2703, SEQ ID NO: 2860, and SEQ ID NO: 3017; SEQ ID NO: 2233, SEQ ID NO: 2390, SEQ ID NO: 2547, SEQ ID NO: 2704, SEQ ID NO: 2861, and SEQ ID NO: 3018; SEQ ID NO: 2234, SEQ ID NO: 2391, SEQ ID NO: 2548, SEQ ID NO: 2705, SEQ ID NO: 2862, and SEQ ID NO: 3019; SEQ ID NO: 2235, SEQ ID NO: 2392, SEQ ID NO: 2549, SEQ ID NO: 2706, SEQ ID NO: 2863, and SEQ ID NO: 3020; SEQ ID NO: 2236, SEQ ID NO: 2393, SEQ ID NO: 2550, SEQ ID NO: 2707, SEQ ID NO: 2864, and SEQ ID NO: 3021; SEQ ID NO: 2237, SEQ ID NO: 2394, SEQ ID NO: 2551, SEQ ID NO: 2708, SEQ ID NO: 2865, and SEQ ID NO: 3022; SEQ ID NO: 2238, SEQ ID NO: 2395, SEQ ID NO: 2552, SEQ ID NO: 2709, SEQ ID NO: 2866, and SEQ ID NO: 3023; SEQ ID NO: 2239, SEQ ID NO: 2396, SEQ ID NO: 2553, SEQ ID NO: 2710, SEQ ID NO: 2867, and SEQ ID NO: 3024; SEQ ID NO: 2240, SEQ ID NO: 2397, SEQ ID NO: 2554, SEQ ID NO: 2711, SEQ ID NO: 2868, and SEQ ID NO: 3025; SEQ ID NO: 2241, SEQ ID NO: 2398, SEQ ID NO: 2555, SEQ ID NO: 2712, SEQ ID NO: 2869, and SEQ ID NO: 3026; SEQ ID NO: 2242, SEQ ID NO: 2399, SEQ ID NO: 2556, SEQ ID NO: 2713, SEQ ID NO: 2870, and SEQ ID NO: 3027; SEQ ID NO: 2243, SEQ ID NO: 2400, SEQ ID NO: 2557, SEQ ID NO: 2714, SEQ ID NO: 2871, and SEQ ID NO: 3028; SEQ ID NO: 2244, SEQ ID NO: 2401, SEQ ID NO: 2558, SEQ ID NO: 2715, SEQ ID NO: 2872, and SEQ ID NO: 3029; SEQ ID NO: 2245, SEQ ID NO: 2402, SEQ ID NO: 2559, SEQ ID NO: 2716, SEQ ID NO: 2873, and SEQ ID NO: 3030; SEQ ID NO: 2246, SEQ ID NO: 2403, SEQ ID NO: 2560, SEQ ID NO: 2717, SEQ ID NO: 2874, and SEQ ID NO: 3031; SEQ ID NO: 2247, SEQ ID NO: 2404, SEQ ID NO: 2561, SEQ ID NO: 2718, SEQ ID NO: 2875, and SEQ ID NO: 3032; SEQ ID NO: 2248, SEQ ID NO: 2405, SEQ ID NO: 2562, SEQ ID NO: 2719, SEQ ID NO: 2876, and SEQ ID NO: 3033; SEQ ID NO: 2249, SEQ ID NO: 2406, SEQ ID NO: 2563, SEQ ID NO: 2720, SEQ ID NO: 2877, and SEQ ID NO: 3034; SEQ ID NO: 2250, SEQ ID NO: 2407, SEQ ID NO: 2564, SEQ ID NO: 2721, SEQ ID NO: 2878, and SEQ ID NO: 3035; SEQ ID NO: 2251, SEQ ID NO: 2408, SEQ ID NO: 2565, SEQ ID NO: 2722, SEQ ID NO: 2879, and SEQ ID NO: 3036; SEQ ID NO: 2252, SEQ ID NO: 2409, SEQ ID NO: 2566, SEQ ID NO: 2723, SEQ ID NO: 2880, and SEQ ID NO: 3037; SEQ ID NO: 2253, SEQ ID NO: 2410, SEQ ID NO: 2567, SEQ ID NO: 2724, SEQ ID NO: 2881, and SEQ ID NO: 3038; SEQ ID NO: 2254, SEQ ID NO: 2411, SEQ ID NO: 2568, SEQ ID NO: 2725, SEQ ID NO: 2882, and SEQ ID NO: 3039; SEQ ID NO: 2255, SEQ ID NO: 2412, SEQ ID NO: 2569, SEQ ID NO: 2726, SEQ ID NO: 2883, and SEQ ID NO: 3040; SEQ ID NO: 2256, SEQ ID NO: 2413, SEQ ID NO: 2570, SEQ ID NO: 2727, SEQ ID NO: 2884, and SEQ ID NO: 3041; SEQ ID NO: 2257, SEQ ID NO: 2414, SEQ ID NO: 2571, SEQ ID NO: 2728, SEQ ID NO: 2885, and SEQ ID NO: 3042; SEQ ID NO: 2258, SEQ ID NO: 2415, SEQ ID NO: 2572, SEQ ID NO: 2729, SEQ ID NO: 2886, and SEQ ID NO: 3043; SEQ ID NO: 2259, SEQ ID NO: 2416, SEQ ID NO: 2573, SEQ ID NO: 2730, SEQ ID NO: 2887, and SEQ ID NO: 3044; SEQ ID NO: 2260, SEQ ID NO: 2417, SEQ ID NO: 2574, SEQ ID NO: 2731, SEQ ID NO: 2888, and SEQ ID NO: 3045; SEQ ID NO: 2261, SEQ ID NO: 2418, SEQ ID NO: 2575, SEQ ID NO: 2732, SEQ ID NO: 2889, and SEQ ID NO: 3046; SEQ ID NO: 2262, SEQ ID NO: 2419, SEQ ID NO: 2576, SEQ ID NO: 2733, SEQ ID NO: 2890, and SEQ ID NO: 3047; SEQ ID NO: 2263, SEQ ID NO: 2420, SEQ ID NO: 2577, SEQ ID NO: 2734, SEQ ID NO: 2891, and SEQ ID NO: 3048; SEQ ID NO: 2264, SEQ ID NO: 2421, SEQ ID NO: 2578, SEQ ID NO: 2735, SEQ ID NO: 2892, and SEQ ID NO: 3049; SEQ ID NO: 2265, SEQ ID NO: 2422, SEQ ID NO: 2579, SEQ ID NO: 2736, SEQ ID NO: 2893, and SEQ ID NO: 3050; SEQ ID NO: 2266, SEQ ID NO: 2423, SEQ ID NO: 2580, SEQ ID NO: 2737, SEQ ID NO: 2894, and SEQ ID NO: 3051; SEQ ID NO: 2267, SEQ ID NO: 2424, SEQ ID NO: 2581, SEQ ID NO: 2738, SEQ ID NO: 2895, and SEQ ID NO: 3052; SEQ ID NO: 2268, SEQ ID NO: 2425, SEQ ID NO: 2582, SEQ ID NO: 2739, SEQ ID NO: 2896, and SEQ ID NO: 3053; SEQ ID NO: 2269, SEQ ID NO: 2426, SEQ ID NO: 2583, SEQ ID NO: 2740, SEQ ID NO: 2897, and SEQ ID NO: 3054; SEQ ID NO: 2270, SEQ ID NO: 2427, SEQ ID NO: 2584, SEQ ID NO: 2741, SEQ ID NO: 2898, and SEQ ID NO: 3055; SEQ ID NO: 2271, SEQ ID NO: 2428, SEQ ID NO: 2585, SEQ ID NO: 2742, SEQ ID NO: 2899, and SEQ ID NO: 3056; SEQ ID NO: 2272, SEQ ID NO: 2429, SEQ ID NO: 2586, SEQ ID NO: 2743, SEQ ID NO: 2900, and SEQ ID NO: 3057; SEQ ID NO: 2273, SEQ ID NO: 2430, SEQ ID NO: 2587, SEQ ID NO: 2744, SEQ ID NO: 2901, and SEQ ID NO: 3058; SEQ ID NO: 2274, SEQ ID NO: 2431, SEQ ID NO: 2588, SEQ ID NO: 2745, SEQ ID NO: 2902, and SEQ ID NO: 3059; SEQ ID NO: 2275, SEQ ID NO: 2432, SEQ ID NO: 2589, SEQ ID NO: 2746, SEQ ID NO: 2903, and SEQ ID NO: 3060; SEQ ID NO: 2276, SEQ ID NO: 2433, SEQ ID NO: 2590, SEQ ID NO: 2747, SEQ ID NO: 29114, and SEQ ID NO: 3061; SEQ ID NO: 2277, SEQ ID NO: 2434, SEQ ID NO: 2591, SEQ ID NO: 2748, SEQ ID NO: 2905, and SEQ ID NO: 3062; SEQ ID NO: 2278, SEQ ID NO: 2435, SEQ ID NO: 2592, SEQ ID NO: 2749, SEQ ID NO: 2906, and SEQ ID NO: 3063; SEQ ID NO: 2279, SEQ ID NO: 2436, SEQ ID NO: 2593, SEQ ID NO: 2750, SEQ ID NO: 2907, and SEQ ID NO: 3064; SEQ ID NO: 2280, SEQ ID NO: 2437, SEQ ID NO: 2594, SEQ ID NO: 2751, SEQ ID NO: 2908, and SEQ ID NO: 3065; SEQ ID NO: 2281, SEQ ID NO: 2438, SEQ ID NO: 2595, SEQ ID NO: 2752, SEQ ID NO: 2909, and SEQ ID NO: 3066; SEQ ID NO: 2282, SEQ ID NO: 2439, SEQ ID NO: 2596, SEQ ID NO: 2753, SEQ ID NO: 2910, and SEQ ID NO: 3067; SEQ ID NO: 2283, SEQ ID NO: 2440, SEQ ID NO: 2597, SEQ ID NO: 2754, SEQ ID NO: 2911, and SEQ ID NO: 3068; SEQ ID NO: 2284, SEQ ID NO: 2441, SEQ ID NO: 2598, SEQ ID NO: 2755, SEQ ID NO: 2912, and SEQ ID NO: 3069; SEQ ID NO: 2285, SEQ ID NO: 2442, SEQ ID NO: 2599, SEQ ID NO: 2756, SEQ ID NO: 2913, and SEQ ID NO: 3070; SEQ ID NO: 2286, SEQ ID NO: 2443, SEQ ID NO: 2600, SEQ ID NO: 2757, SEQ ID NO: 2914, and SEQ ID NO: 3071; SEQ ID NO: 2287, SEQ ID NO: 2444, SEQ ID NO: 2601, SEQ ID NO: 2758, SEQ ID NO: 2915, and SEQ ID NO: 3072; SEQ ID NO: 2288, SEQ ID NO: 2445, SEQ ID NO: 2602, SEQ ID NO: 2759, SEQ ID NO: 2916, and SEQ ID NO: 3073; SEQ ID NO: 2289, SEQ ID NO: 2446, SEQ ID NO: 2603, SEQ ID NO: 2760, SEQ ID NO: 2917, and SEQ ID NO: 3074; SEQ ID NO: 2290, SEQ ID NO: 2447, SEQ ID NO: 2604, SEQ ID NO: 2761, SEQ ID NO: 2918, and SEQ ID NO: 3075; SEQ ID NO: 2291, SEQ ID NO: 2448, SEQ ID NO: 2605, SEQ ID NO: 2762, SEQ ID NO: 2919, and SEQ ID NO: 3076; SEQ ID NO: 2292, SEQ ID NO: 2449, SEQ ID NO: 2606, SEQ ID NO: 2763, SEQ ID NO: 2920, and SEQ ID NO: 3077; SEQ ID NO: 2293, SEQ ID NO: 2450, SEQ ID NO: 2607, SEQ ID NO: 2764, SEQ ID NO: 2921, and SEQ ID NO: 3078; SEQ ID NO: 2294, SEQ ID NO: 2451, SEQ ID NO: 2608, SEQ ID NO: 2765, SEQ ID NO: 2922, and SEQ ID NO: 3079; SEQ ID NO: 2295, SEQ ID NO: 2452, SEQ ID NO: 2609, SEQ ID NO: 2766, SEQ ID NO: 2923, and SEQ ID NO: 3080; SEQ ID NO: 2296, SEQ ID NO: 2453, SEQ ID NO: 2610, SEQ ID NO: 2767, SEQ ID NO: 2924, and SEQ ID NO: 3081; SEQ ID NO: 2297, SEQ ID NO: 2454, SEQ ID NO: 2611, SEQ ID NO: 2768, SEQ ID NO: 2925, and SEQ ID NO: 3082; SEQ ID NO: 2298, SEQ ID NO: 2455, SEQ ID NO: 2612, SEQ ID NO: 2769, SEQ ID NO: 2926, and SEQ ID NO: 3083; SEQ ID NO: 2299, SEQ ID NO: 2456, SEQ ID NO: 2613, SEQ ID NO: 2770, SEQ ID NO: 2927, and SEQ ID NO: 3084; SEQ ID NO: 2300, SEQ ID NO: 2457, SEQ ID NO: 2614, SEQ ID NO: 2771, SEQ ID NO: 2928, and SEQ ID NO: 3085; SEQ ID NO: 2301, SEQ ID NO: 2458, SEQ ID NO: 2615, SEQ ID NO: 2772, SEQ ID NO: 2929, and SEQ ID NO: 3086; SEQ ID NO: 2302, SEQ ID NO: 2459, SEQ ID NO: 2616, SEQ ID NO: 2773, SEQ ID NO: 2930, and SEQ ID NO: 3087; SEQ ID NO: 2303, SEQ ID NO: 2460, SEQ ID NO: 2617, SEQ ID NO: 2774, SEQ ID NO: 2931, and SEQ ID NO: 3088; SEQ ID NO: 2304, SEQ ID NO: 2461, SEQ ID NO: 2618, SEQ ID NO: 2775, SEQ ID NO: 2932, and SEQ ID NO: 3089; SEQ ID NO: 2305, SEQ ID NO: 2462, SEQ ID NO: 2619, SEQ ID NO: 2776, SEQ ID NO: 2933, and SEQ ID NO: 3090; SEQ ID NO: 2306, SEQ ID NO: 2463, SEQ ID NO: 2620, SEQ ID NO: 2777, SEQ ID NO: 2934, and SEQ ID NO: 3091; SEQ ID NO: 2307, SEQ ID NO: 2464, SEQ ID NO: 2621, SEQ ID NO: 2778, SEQ ID NO: 2935, and SEQ ID NO: 3092; SEQ ID NO: 2308, SEQ ID NO: 2465, SEQ ID NO: 2622, SEQ ID NO: 2779, SEQ ID NO: 2936, and SEQ ID NO: 3093; SEQ ID NO: 2309, SEQ ID NO: 2466, SEQ ID NO: 2623, SEQ ID NO: 2780, SEQ ID NO: 2937, and SEQ ID NO: 3094; SEQ ID NO: 2310, SEQ ID NO: 2467, SEQ ID NO: 2624, SEQ ID NO: 2781, SEQ ID NO: 2938, and SEQ ID NO: 3095; SEQ ID NO: 2311, SEQ ID NO: 2468, SEQ ID NO: 2625, SEQ ID NO: 2782, SEQ ID NO: 2939, and SEQ ID NO: 3096; SEQ ID NO: 2312, SEQ ID NO: 2469, SEQ ID NO: 2626, SEQ ID NO: 2783, SEQ ID NO: 2940, and SEQ ID NO: 3097; SEQ ID NO: 2313, SEQ ID NO: 2470, SEQ ID NO: 2627, SEQ ID NO: 2784, SEQ ID NO: 2941, and SEQ ID NO: 3098; SEQ ID NO: 2314, SEQ ID NO: 2471, SEQ ID NO: 2628, SEQ ID NO: 2785, SEQ ID NO: 2942, and SEQ ID NO: 3099; SEQ ID NO: 2315, SEQ ID NO: 2472, SEQ ID NO: 2629, SEQ ID NO: 2786, SEQ ID NO: 2943, and SEQ ID NO: 3100; SEQ ID NO: 2316, SEQ ID NO: 2473, SEQ ID NO: 2630, SEQ ID NO: 2787, SEQ ID NO: 2944, and SEQ ID NO: 3101; SEQ ID NO: 2317, SEQ ID NO: 2474, SEQ ID NO: 2631, SEQ ID NO: 2788, SEQ ID NO: 2945, and SEQ ID NO: 3102; SEQ ID NO: 2318, SEQ ID NO: 2475, SEQ ID NO: 2632, SEQ ID NO: 2789, SEQ ID NO: 2946, and SEQ ID NO: 3103; SEQ ID NO: 2319, SEQ ID NO: 2476, SEQ ID NO: 2633, SEQ ID NO: 2790, SEQ ID NO: 2947, and SEQ ID NO: 3104; SEQ ID NO: 2320, SEQ ID NO: 2477, SEQ ID NO: 2634, SEQ ID NO: 2791, SEQ ID NO: 2948, and SEQ ID NO: 3105; SEQ ID NO: 2321, SEQ ID NO: 2478, SEQ ID NO: 2635, SEQ ID NO: 2792, SEQ ID NO: 2949, and SEQ ID NO: 3106; SEQ ID NO: 2322, SEQ ID NO: 2479, SEQ ID NO: 2636, SEQ ID NO: 2793, SEQ ID NO: 2950, and SEQ ID NO: 3107; SEQ ID NO: 2323, SEQ ID NO: 2480, SEQ ID NO: 2637, SEQ ID NO: 2794, SEQ ID NO: 2951, and SEQ ID NO: 3108; SEQ ID NO: 2324, SEQ ID NO: 2481, SEQ ID NO: 2638, SEQ ID NO: 2795, SEQ ID NO: 2952, and SEQ ID NO: 3109; SEQ ID NO: 2325, SEQ ID NO: 2482, SEQ ID NO: 2639, SEQ ID NO: 2796, SEQ ID NO: 2953, and SEQ ID NO: 3110; SEQ ID NO: 2326, SEQ ID NO: 2483, SEQ ID NO: 2640, SEQ ID NO: 2797, SEQ ID NO: 2954, and SEQ ID NO: 3111; SEQ ID NO: 2327, SEQ ID NO: 2484, SEQ ID NO: 2641, SEQ ID NO: 2798, SEQ ID NO: 2955, and SEQ ID NO: 3112; SEQ ID NO: 2328, SEQ ID NO: 2485, SEQ ID NO: 2642, SEQ ID NO: 2799, SEQ ID NO: 2956, and SEQ ID NO: 3113; SEQ ID NO: 2329, SEQ ID NO: 2486, SEQ ID NO: 2643, SEQ ID NO: 2800, SEQ ID NO: 2957, and SEQ ID NO: 3114; SEQ ID NO: 2330, SEQ ID NO: 2487, SEQ ID NO: 2644, SEQ ID NO: 2801, SEQ ID NO: 2958, and SEQ ID NO: 3115; SEQ ID NO: 2331, SEQ ID NO: 2488, SEQ ID NO: 2645, SEQ ID NO: 2802, SEQ ID NO: 2959, and SEQ ID NO: 3116; SEQ ID NO: 2332, SEQ ID NO: 2489, SEQ ID NO: 2646, SEQ ID NO: 2803, SEQ ID NO: 2960, and SEQ ID NO: 3117; SEQ ID NO: 2333, SEQ ID NO: 2490, SEQ ID NO: 2647, SEQ ID NO: 2804, SEQ ID NO: 2961, and SEQ ID NO: 3118; SEQ ID NO: 2334, SEQ ID NO: 2491, SEQ ID NO: 2648, SEQ ID NO: 2805, SEQ ID NO: 2962, and SEQ ID NO: 3119; SEQ ID NO: 2335, SEQ ID NO: 2492, SEQ ID NO: 2649, SEQ ID NO: 2806, SEQ ID NO: 2963, and SEQ ID NO: 3120; SEQ ID NO: 2336, SEQ ID NO: 2493, SEQ ID NO: 2650, SEQ ID NO: 2807, SEQ ID NO: 2964, and SEQ ID NO: 3121; SEQ ID NO: 2337, SEQ ID NO: 2494, SEQ ID NO: 2651, SEQ ID NO: 2808, SEQ ID NO: 2965, and SEQ ID NO: 3122; SEQ ID NO: 2338, SEQ ID NO: 2495, SEQ ID NO: 2652, SEQ ID NO: 2809, SEQ ID NO: 2966, and SEQ ID NO: 3123; SEQ ID NO: 2339, SEQ ID NO: 2496, SEQ ID NO: 2653, SEQ ID NO: 2810, SEQ ID NO: 2967, and SEQ ID NO: 3124; SEQ ID NO: 2340, SEQ ID NO: 2497, SEQ ID NO: 2654, SEQ ID NO: 2811, SEQ ID NO: 2968, and SEQ ID NO: 3125; SEQ ID NO: 2341, SEQ ID NO: 2498, SEQ ID NO: 2655, SEQ ID NO: 2812, SEQ ID NO: 2969, and SEQ ID NO: 3126; SEQ ID NO: 2342, SEQ ID NO: 2499, SEQ ID NO: 2656, SEQ ID NO: 2813, SEQ ID NO: 2970, and SEQ ID NO: 3127; SEQ ID NO: 2343, SEQ ID NO: 2500, SEQ ID NO: 2657, SEQ ID NO: 2814, SEQ ID NO: 2971, and SEQ ID NO: 3128; SEQ ID NO: 2344, SEQ ID NO: 2501, SEQ ID NO: 2658, SEQ ID NO: 2815, SEQ ID NO: 2972, and SEQ ID NO: 3129; SEQ ID NO: 2345, SEQ ID NO: 2502, SEQ ID NO: 2659, SEQ ID NO: 2816, SEQ ID NO: 2973, and SEQ ID NO: 3130; SEQ ID NO: 2346, SEQ ID NO: 2503, SEQ ID NO: 2660, SEQ ID NO: 2817, SEQ ID NO: 2974, and SEQ ID NO: 3131; SEQ ID NO: 2347, SEQ ID NO: 2504, SEQ ID NO: 2661, SEQ ID NO: 2818, SEQ ID NO: 2975, and SEQ ID NO: 3132; SEQ ID NO: 2348, SEQ ID NO: 2505, SEQ ID NO: 2662, SEQ ID NO: 2819, SEQ ID NO: 2976, and SEQ ID NO: 3133; SEQ ID NO: 2349, SEQ ID NO: 2506, SEQ ID NO: 2663, SEQ ID NO: 2820, SEQ ID NO: 2977, and SEQ ID NO: 3134; SEQ ID NO: 2350, SEQ ID NO: 2507, SEQ ID NO: 2664, SEQ ID NO: 2821, SEQ ID NO: 2978, and SEQ ID NO: 3135; SEQ ID NO: 2351, SEQ ID NO: 2508, SEQ ID NO: 2665, SEQ ID NO: 2822, SEQ ID NO: 2979, and SEQ ID NO: 3136; SEQ ID NO: 2352, SEQ ID NO: 2509, SEQ ID NO: 2666, SEQ ID NO: 2823, SEQ ID NO: 2980, and SEQ ID NO: 3137; SEQ ID NO: 2353, SEQ ID NO: 2510, SEQ ID NO: 2667, SEQ ID NO: 2824, SEQ ID NO: 2981, and SEQ ID NO: 3138; SEQ ID NO: 2354, SEQ ID NO: 2511, SEQ ID NO: 2668, SEQ ID NO: 2825, SEQ ID NO: 2982, and SEQ ID NO: 3139; and SEQ ID NO: 2355, SEQ ID NO: 2512, SEQ ID NO: 2669, SEQ ID NO: 2826, SEQ ID NO: 2983, and SEQ ID NO: 3140.

In another aspect, an antigen binding protein includes 1, 2, 3, 4, 5, or 6 variant forms of the CDRs listed in TABLES 4A and 4B, each having at least 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% sequence identity to a CDR sequence listed in TABLES 4A and 4B. Some antigen binding proteins include 1, 2, 3, 4, 5, or 6 of the CDRs listed in TABLES 4A and 4B, each or collectively differing by no more than 1, 2, 3, 4 or 5 amino acids from the CDRs listed in this table.

In various other embodiments, the antigen binding protein is derived from such antibodies. For instance, in one aspect, the antigen binding protein comprises 1, 2, 3, 4, 5 or all 6 of the CDRs listed in one of the rows for any particular antibody listed in TABLES 4A and 4B. In another aspect, an antigen binding protein includes 1, 2, 3, 4, 5, or 6 variant forms of the CDRs listed in one of the rows for an antibody in TABLES 4A and 4B, each CDR having at least 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% sequence identity to a CDR sequence listed in TABLES 4A and 4B. Some antigen binding proteins include 1, 2, 3, 4, 5, or 6 of the CDRs listed in one of the rows of TABLES 4A and 4B, each differing by no more than 1, 2, 3, 4 or 5 amino acids from the CDRs listed in these tables. In another aspect, the antigen binding protein comprises all 6 of the CDRS listed in a row of TABLES 4A and 4B and the total number of amino acid changes to the CDRs collectively is no more than 1, 2, 3, 4, or 5 amino acids.

In one embodiment the antibody or fragment thereof comprises a light chain comprising a sequence selected from the group consisting of SEQ ID NOs: 472-628 and a heavy chain comprising a sequence selected from the group consisting of SEQ ID NOs: 472-628, wherein the antibody or functional fragment thereof comprises a cysteine or non-canonical amino acid amino acid substitution at one or more conjugation site(s) selected from the group consisting of D70 of the antibody light chain relative to reference sequence SEQ ID NO: 455, E276 of the antibody heavy chain relative to reference sequence SEQ ID NO: 612, and T363 of the antibody heavy chain relative to reference sequence SEQ ID NO: 612. In one embodiment the antibody or fragment thereof comprises a combination of a light chain and a heavy chain selected from the group consisting of a light chain comprising SEQ ID NO: 315 and a heavy chain comprising SEQ ID NO: 472; a light chain comprising SEQ ID NO: 316 and a heavy chain comprising SEQ ID NO: 473; a light chain comprising SEQ ID NO: 317 and a heavy chain comprising SEQ ID NO: 474; a light chain comprising SEQ ID NO: 318 and a heavy chain comprising SEQ ID NO: 475; a light chain comprising SEQ ID NO: 319 and a heavy chain comprising SEQ ID NO: 476; a light chain comprising SEQ ID NO: 320 and a heavy chain comprising SEQ ID NO: 477; a light chain comprising SEQ ID NO: 321 and a heavy chain comprising SEQ ID NO: 478; a light chain comprising SEQ ID NO: 322 and a heavy chain comprising SEQ ID NO: 479; a light chain comprising SEQ ID NO: 323 and a heavy chain comprising SEQ ID NO: 480; a light chain comprising SEQ ID NO: 324 and a heavy chain comprising SEQ ID NO: 481; a light chain comprising SEQ ID NO: 325 and a heavy chain comprising SEQ ID NO: 482; a light chain comprising SEQ ID NO: 326 and a heavy chain comprising SEQ ID NO: 483; a light chain comprising SEQ ID NO: 327 and a heavy chain comprising SEQ ID NO: 484; a light chain comprising SEQ ID NO: 328 and a heavy chain comprising SEQ ID NO: 485; a light chain comprising SEQ ID NO: 329 and a heavy chain comprising SEQ ID NO: 486; a light chain comprising SEQ ID NO: 330 and a heavy chain comprising SEQ ID NO: 487; a light chain comprising SEQ ID NO: 331 and a heavy chain comprising SEQ ID NO: 488; a light chain comprising SEQ ID NO: 332 and a heavy chain comprising SEQ ID NO: 489; a light chain comprising SEQ ID NO: 333 and a heavy chain comprising SEQ ID NO: 490; a light chain comprising SEQ ID NO: 334 and a heavy chain comprising SEQ ID NO: 491; a light chain comprising SEQ ID NO: 335 and a heavy chain comprising SEQ ID NO: 492; a light chain comprising SEQ ID NO: 336 and a heavy chain comprising SEQ ID NO: 493; a light chain comprising SEQ ID NO: 337 and a heavy chain comprising SEQ ID NO: 494; a light chain comprising SEQ ID NO: 338 and a heavy chain comprising SEQ ID NO: 495; a light chain comprising SEQ ID NO: 339 and a heavy chain comprising SEQ ID NO: 496; a light chain comprising SEQ ID NO: 340 and a heavy chain comprising SEQ ID NO: 497; a light chain comprising SEQ ID NO: 341 and a heavy chain comprising SEQ ID NO: 498; a light chain comprising SEQ ID NO: 342 and a heavy chain comprising SEQ ID NO: 499; a light chain comprising SEQ ID NO: 343 and a heavy chain comprising SEQ ID NO: 500; a light chain comprising SEQ ID NO: 344 and a heavy chain comprising SEQ ID NO: 501; a light chain comprising SEQ ID NO: 345 and a heavy chain comprising SEQ ID NO: 502; a light chain comprising SEQ ID NO: 346 and a heavy chain comprising SEQ ID NO: 503; a light chain comprising SEQ ID NO: 347 and a heavy chain comprising SEQ ID NO: 504; a light chain comprising SEQ ID NO: 348 and a heavy chain comprising SEQ ID NO: 505; a light chain comprising SEQ ID NO: 349 and a heavy chain comprising SEQ ID NO: 506; a light chain comprising SEQ ID NO: 350 and a heavy chain comprising SEQ ID NO: 507; a light chain comprising SEQ ID NO: 351 and a heavy chain comprising SEQ ID NO: 508; a light chain comprising SEQ ID NO: 352 and a heavy chain comprising SEQ ID NO: 509; a light chain comprising SEQ ID NO: 353 and a heavy chain comprising SEQ ID NO: 510; a light chain comprising SEQ ID NO: 354 and a heavy chain comprising SEQ ID NO: 511; a light chain comprising SEQ ID NO: 355 and a heavy chain comprising SEQ ID NO: 512; a light chain comprising SEQ ID NO: 356 and a heavy chain comprising SEQ ID NO: 513; a light chain comprising SEQ ID NO: 357 and a heavy chain comprising SEQ ID NO: 514; a light chain comprising SEQ ID NO: 358 and a heavy chain comprising SEQ ID NO: 515; a light chain comprising SEQ ID NO: 359 and a heavy chain comprising SEQ ID NO: 516; a light chain comprising SEQ ID NO: 360 and a heavy chain comprising SEQ ID NO: 517; a light chain comprising SEQ ID NO: 361 and a heavy chain comprising SEQ ID NO: 518; a light chain comprising SEQ ID NO: 362 and a heavy chain comprising SEQ ID NO: 519; a light chain comprising SEQ ID NO: 363 and a heavy chain comprising SEQ ID NO: 520; a light chain comprising SEQ ID NO: 364 and a heavy chain comprising SEQ ID NO: 521; a light chain comprising SEQ ID NO: 365 and a heavy chain comprising SEQ ID NO: 522; a light chain comprising SEQ ID NO: 366 and a heavy chain comprising SEQ ID NO: 523; a light chain comprising SEQ ID NO: 367 and a heavy chain comprising SEQ ID NO: 524; a light chain comprising SEQ ID NO: 368 and a heavy chain comprising SEQ ID NO: 525; a light chain comprising SEQ ID NO: 369 and a heavy chain comprising SEQ ID NO: 526; a light chain comprising SEQ ID NO: 370 and a heavy chain comprising SEQ ID NO: 527; a light chain comprising SEQ ID NO: 371 and a heavy chain comprising SEQ ID NO: 528; a light chain comprising SEQ ID NO: 372 and a heavy chain comprising SEQ ID NO: 529; a light chain comprising SEQ ID NO: 373 and a heavy chain comprising SEQ ID NO: 530; a light chain comprising SEQ ID NO: 374 and a heavy chain comprising SEQ ID NO: 531; a light chain comprising SEQ ID NO: 375 and a heavy chain comprising SEQ ID NO: 532; a light chain comprising SEQ ID NO: 376 and a heavy chain comprising SEQ ID NO: 533; a light chain comprising SEQ ID NO: 377 and a heavy chain comprising SEQ ID NO: 534; a light chain comprising SEQ ID NO: 378 and a heavy chain comprising SEQ ID NO: 535; a light chain comprising SEQ ID NO: 379 and a heavy chain comprising SEQ ID NO: 536; a light chain comprising SEQ ID NO: 380 and a heavy chain comprising SEQ ID NO: 537; a light chain comprising SEQ ID NO: 381 and a heavy chain comprising SEQ ID NO: 538; a light chain comprising SEQ ID NO: 382 and a heavy chain comprising SEQ ID NO: 539; a light chain comprising SEQ ID NO: 383 and a heavy chain comprising SEQ ID NO: 540; a light chain comprising SEQ ID NO: 384 and a heavy chain comprising SEQ ID NO: 541; a light chain comprising SEQ ID NO: 385 and a heavy chain comprising SEQ ID NO: 542; a light chain comprising SEQ ID NO: 386 and a heavy chain comprising SEQ ID NO: 543; a light chain comprising SEQ ID NO: 387 and a heavy chain comprising SEQ ID NO: 544; a light chain comprising SEQ ID NO: 388 and a heavy chain comprising SEQ ID NO: 545; a light chain comprising SEQ ID NO: 389 and a heavy chain comprising SEQ ID NO: 546; a light chain comprising SEQ ID NO: 390 and a heavy chain comprising SEQ ID NO: 547; a light chain comprising SEQ ID NO: 391 and a heavy chain comprising SEQ ID NO: 548; a light chain comprising SEQ ID NO: 392 and a heavy chain comprising SEQ ID NO: 549; a light chain comprising SEQ ID NO: 393 and a heavy chain comprising SEQ ID NO: 550; a light chain comprising SEQ ID NO: 394 and a heavy chain comprising SEQ ID NO: 551; a light chain comprising SEQ ID NO: 395 and a heavy chain comprising SEQ ID NO: 552; a light chain comprising SEQ ID NO: 396 and a heavy chain comprising SEQ ID NO: 553; a light chain comprising SEQ ID NO: 397 and a heavy chain comprising SEQ ID NO: 554; a light chain comprising SEQ ID NO: 398 and a heavy chain comprising SEQ ID NO: 555; a light chain comprising SEQ ID NO: 399 and a heavy chain comprising SEQ ID NO: 556; a light chain comprising SEQ ID NO: 400 and a heavy chain comprising SEQ ID NO: 557; a light chain comprising SEQ ID NO: 401 and a heavy chain comprising SEQ ID NO: 558; a light chain comprising SEQ ID NO: 402 and a heavy chain comprising SEQ ID NO: 559; a light chain comprising SEQ ID NO: 403 and a heavy chain comprising SEQ ID NO: 560; a light chain comprising SEQ ID NO: 404 and a heavy chain comprising SEQ ID NO: 561; a light chain comprising SEQ ID NO: 405 and a heavy chain comprising SEQ ID NO: 562; a light chain comprising SEQ ID NO: 406 and a heavy chain comprising SEQ ID NO: 563; a light chain comprising SEQ ID NO: 407 and a heavy chain comprising SEQ ID NO: 564; a light chain comprising SEQ ID NO: 408 and a heavy chain comprising SEQ ID NO: 565; a light chain comprising SEQ ID NO: 409 and a heavy chain comprising SEQ ID NO: 566; a light chain comprising SEQ ID NO: 410 and a heavy chain comprising SEQ ID NO: 567; a light chain comprising SEQ ID NO: 411 and a heavy chain comprising SEQ ID NO: 568; a light chain comprising SEQ ID NO: 412 and a heavy chain comprising SEQ ID NO: 569; a light chain comprising SEQ ID NO: 413 and a heavy chain comprising SEQ ID NO: 570; a light chain comprising SEQ ID NO: 414 and a heavy chain comprising SEQ ID NO: 571; a light chain comprising SEQ ID NO: 415 and a heavy chain comprising SEQ ID NO: 572; a light chain comprising SEQ ID NO: 416 and a heavy chain comprising SEQ ID NO: 573; a light chain comprising SEQ ID NO: 417 and a heavy chain comprising SEQ ID NO: 574; a light chain comprising SEQ ID NO: 418 and a heavy chain comprising SEQ ID NO: 575; a light chain comprising SEQ ID NO: 419 and a heavy chain comprising SEQ ID NO: 576; a light chain comprising SEQ ID NO: 420 and a heavy chain comprising SEQ ID NO: 577; a light chain comprising SEQ ID NO: 421 and a heavy chain comprising SEQ ID NO: 578; a light chain comprising SEQ ID NO: 422 and a heavy chain comprising SEQ ID NO: 579; a light chain comprising SEQ ID NO: 423 and a heavy chain comprising SEQ ID NO: 580; a light chain comprising SEQ ID NO: 424 and a heavy chain comprising SEQ ID NO: 581; a light chain comprising SEQ ID NO: 425 and a heavy chain comprising SEQ ID NO: 582; a light chain comprising SEQ ID NO: 426 and a heavy chain comprising SEQ ID NO: 583; a light chain comprising SEQ ID NO: 427 and a heavy chain comprising SEQ ID NO: 584; a light chain comprising SEQ ID NO: 428 and a heavy chain comprising SEQ ID NO: 585; a light chain comprising SEQ ID NO: 429 and a heavy chain comprising SEQ ID NO: 586; a light chain comprising SEQ ID NO: 430 and a heavy chain comprising SEQ ID NO: 587; a light chain comprising SEQ ID NO: 431 and a heavy chain comprising SEQ ID NO: 588; a light chain comprising SEQ ID NO: 432 and a heavy chain comprising SEQ ID NO: 589; a light chain comprising SEQ ID NO: 433 and a heavy chain comprising SEQ ID NO: 590; a light chain comprising SEQ ID NO: 434 and a heavy chain comprising SEQ ID NO: 591; a light chain comprising SEQ ID NO: 435 and a heavy chain comprising SEQ ID NO: 592; a light chain comprising SEQ ID NO: 436 and a heavy chain comprising SEQ ID NO: 593; a light chain comprising SEQ ID NO: 437 and a heavy chain comprising SEQ ID NO: 594; a light chain comprising SEQ ID NO: 438 and a heavy chain comprising SEQ ID NO: 595; a light chain comprising SEQ ID NO: 439 and a heavy chain comprising SEQ ID NO: 596; a light chain comprising SEQ ID NO: 440 and a heavy chain comprising SEQ ID NO: 597; a light chain comprising SEQ ID NO: 441 and a heavy chain comprising SEQ ID NO: 598; a light chain comprising SEQ ID NO: 442 and a heavy chain comprising SEQ ID NO: 599; a light chain comprising SEQ ID NO: 443 and a heavy chain comprising SEQ ID NO: 600; a light chain comprising SEQ ID NO: 444 and a heavy chain comprising SEQ ID NO: 601; a light chain comprising SEQ ID NO: 445 and a heavy chain comprising SEQ ID NO: 602; a light chain comprising SEQ ID NO: 446 and a heavy chain comprising SEQ ID NO: 603; a light chain comprising SEQ ID NO: 447 and a heavy chain comprising SEQ ID NO: 604; a light chain comprising SEQ ID NO: 448 and a heavy chain comprising SEQ ID NO: 605; a light chain comprising SEQ ID NO: 449 and a heavy chain comprising SEQ ID NO: 606; a light chain comprising SEQ ID NO: 450 and a heavy chain comprising SEQ ID NO: 607; a light chain comprising SEQ ID NO: 451 and a heavy chain comprising SEQ ID NO: 608; a light chain comprising SEQ ID NO: 452 and a heavy chain comprising SEQ ID NO: 609; a light chain comprising SEQ ID NO: 453 and a heavy chain comprising SEQ ID NO: 610; a light chain comprising SEQ ID NO: 454 and a heavy chain comprising SEQ ID NO: 611; a light chain comprising SEQ ID NO: 455 and a heavy chain comprising SEQ ID NO: 612; a light chain comprising SEQ ID NO: 456 and a heavy chain comprising SEQ ID NO: 613; a light chain comprising SEQ ID NO: 457 and a heavy chain comprising SEQ ID NO: 614; a light chain comprising SEQ ID NO: 458 and a heavy chain comprising SEQ ID NO: 615; a light chain comprising SEQ ID NO: 459 and a heavy chain comprising SEQ ID NO: 616; a light chain comprising SEQ ID NO: 460 and a heavy chain comprising SEQ ID NO: 617; a light chain comprising SEQ ID NO: 461 and a heavy chain comprising SEQ ID NO: 618; a light chain comprising SEQ ID NO: 462 and a heavy chain comprising SEQ ID NO: 619; a light chain comprising SEQ ID NO: 463 and a heavy chain comprising SEQ ID NO: 620; a light chain comprising SEQ ID NO: 464 and a heavy chain comprising SEQ ID NO: 621; a light chain comprising SEQ ID NO: 465 and a heavy chain comprising SEQ ID NO: 622; a light chain comprising SEQ ID NO: 466 and a heavy chain comprising SEQ ID NO: 623; a light chain comprising SEQ ID NO: 467 and a heavy chain comprising SEQ ID NO: 624; a light chain comprising SEQ ID NO: 468 and a heavy chain comprising SEQ ID NO: 625; a light chain comprising SEQ ID NO: 469 and a heavy chain comprising SEQ ID NO: 626; a light chain comprising SEQ ID NO: 470 and a heavy chain comprising SEQ ID NO: 627; and a light chain comprising SEQ ID NO: 471 and a heavy chain comprising SEQ ID NO: 628, wherein the antibody or functional fragment thereof comprises a cysteine or non-canonical amino acid amino acid substitution at one or more conjugation site(s) selected from the group consisting of D70 of the antibody light chain relative to reference sequence SEQ ID NO: 455, E276 of the antibody heavy chain relative to reference sequence SEQ ID NO: 612, and T363 of the antibody heavy chain relative to reference sequence SEQ ID NO: 612.

In one embodiment the antibody or fragment thereof comprises a light chain encoded by a polynucleotide sequence selected from the group consisting of SEQ ID NOs: 1885-2014 and a heavy chain comprising a sequence selected from the group consisting of SEQ ID NOs: 2042-2198, wherein the antibody or functional fragment thereof comprises a cysteine or non-canonical amino acid amino acid substitution at one or more conjugation site(s) selected from the group consisting of D70 of the antibody light chain relative to reference sequence SEQ ID NO: 455, E276 of the antibody heavy chain relative to reference sequence SEQ ID NO: 612, and T363 of the antibody heavy chain relative to reference sequence SEQ ID NO: 612. In one embodiment the antibody or fragment thereof comprises a combination of a light chain and a heavy chain, wherein the antibody or functional fragment thereof comprises a cysteine or non-canonical amino acid amino acid substitution at one or more conjugation site(s) selected from the group consisting of D70 of the antibody light chain relative to reference sequence SEQ ID NO: 455, E276 of the antibody heavy chain relative to reference sequence SEQ ID NO: 612, and T363 of the antibody heavy chain relative to reference sequence SEQ ID NO: 612, selected from the group consisting of a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1885 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2042; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1886 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2043; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1887 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2044; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1888 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2045; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1889 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2046; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1890 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2047; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1891 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2048; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1892 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2049; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1893 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2050; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1894 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2051; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1895 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2052; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1896 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2053; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1897 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2054; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1898 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2055; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1899 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2056; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1900 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2057; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1901 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2058; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1902 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2059; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1903 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2060; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1904 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2061; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1905 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2062; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1906 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2063; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1907 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2064; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1908 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2065; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1909 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2066; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1910 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2067; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1911 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2068; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1912 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2069; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1913 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2070; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1914 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2071; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1915 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2072; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1916 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2073; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1917 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2074; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1918 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2075; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1919 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2076; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1920 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2077; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1921 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2078; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1922 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2079; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1923 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2080; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1924 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2081; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1925 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2082; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1926 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2083; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1927 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2084; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1928 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2085; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1929 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2086; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1930 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2087; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1931 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2088; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1932 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2089; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1933 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2090; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1934 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2091; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1935 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2092; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1936 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2093; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1937 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2094; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1938 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2095; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1939 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2096; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1940 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2097; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1941 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2098; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1942 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2099; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1943 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2100; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1944 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2101; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1945 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2102; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1946 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2103; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1947 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2104; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1948 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2105; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1949 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2106; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1950 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2107; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1951 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2108; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1952 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2109; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1953 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2110; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1954 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2111; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1955 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2112; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1956 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2113; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1957 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2114; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1958 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2115; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1959 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2116; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1960 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2117; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1961 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2118; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1962 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2119; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1963 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2120; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1964 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2121; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1965 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2122; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1966 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2123; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1967 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2124; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1968 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2125; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1969 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2126; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1970 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2127; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1971 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2128; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1972 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2129; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1973 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2130; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1974 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2131; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1975 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2132; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1976 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2133; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1977 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2134; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1978 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2135; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1979 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2136; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1980 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2137; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1981 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2138; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1982 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2139; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1983 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2140; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1984 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2141; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1985 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2142; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1986 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2143; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1987 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2144; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1988 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2145; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1989 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2146; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1990 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2147; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1991 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2148; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1992 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2149; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1993 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2150; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1994 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2151; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1995 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2152; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1996 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2153; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1997 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2154; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1998 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2155; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 1999 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2156; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2000 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2157; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2001 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2158; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2002 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2159; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2003 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2160; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2004 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2161; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2005 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2162; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2006 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2163; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2007 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2164; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2008 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2165; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2009 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2166; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2010 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2167; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2011 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2168; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2012 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2169; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2013 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2170; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2014 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2171; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2015 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2172; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2016 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2173; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2017 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2174; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2018 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2175; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2019 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2176; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2020 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2177; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2021 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2178; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2022 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2179; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2023 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2180; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2024 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2181; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2025 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2182; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2026 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2183; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2027 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2184; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2028 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2185; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2029 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2186; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2030 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2187; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2031 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2188; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2032 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2189; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2033 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2190; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2034 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2191; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2035 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2192; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2036 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2193; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2037 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2194; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2038 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2195; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2039 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2196; a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2040 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2197; and a light chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2041 and a heavy chain encoded by a polynucleotide sequence comprising SEQ ID NO: 2198.

In another aspect, the antigen binding protein comprises a full length light chain and a full length heavy chain as listed in one of the rows for one of the antibodies listed in TABLE 5. Some antigen binding proteins that are provided comprise a full length light chain and a full length heavy chain as listed in one of the rows for one of the antibodies listed in TABLE 5, except that one or both of the chains differs from the sequence specified in the table at only 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 or 15 amino acid residues, wherein each such sequence difference is independently either a single amino acid deletion, insertion or substitution, with the deletions, insertions and/or substitutions resulting in no more than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 or 15 amino acid changes relative to the full length sequences specified in TABLE 5. In one embodiment the antigen binding protein comprises a full length light chain and/or a full length heavy chain from Table 5 with the N-terminal methionine deleted. In one embodiment the antigen binding protein comprises a full length light chain and/or a full length heavy chain from Table 5 with the C-terminal lysine deleted. Other antigen binding proteins also comprise a full length light chain and a full length heavy chain as listed in one of the rows for one of the antibodies listed in TABLE 5, except that one or both of the chains differs from the sequence specified in the table in that the light chain and/or heavy chain comprises or consists of a sequence of amino acids that has at least 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% sequence identity to the amino acid sequences of the light chain or heavy chain sequences as specified in TABLE 5.

In another embodiment, the antigen binding protein consists of a just a light or a heavy chain polypeptide as set forth in TABLE 5.

In still another aspect, antigen-binding proteins containing the CDRs, variable domains and/or full length sequences listed in TABLES 3, 4A, 4B, and 5 is a monoclonal antibody, a chimeric antibody, a humanized antibody, a human antibody, a multispecific antibody, or an antibody fragment of the foregoing. In another embodiment, the antibody fragment of the isolated antigen-binding proteins provided herein is a Fab fragment, a Fab′ fragment, an F(ab′)₂ fragment, an Fv fragment, a diabody, or a scFv based upon an antibody with the sequences as listed in TABLE 5.

In yet another aspect, the isolated antigen-binding protein provided in TABLE 5 can be coupled to a labeling group and can compete for binding to GIPR with an antigen binding protein of one of the isolated antigen-binding proteins provided herein.

In another embodiment, antigen binding proteins are provided that compete with one of the exemplified antibodies or functional fragments described above for specific binding to a human GIPR (e.g., SEQ ID NO: 3141). Such antigen binding proteins may bind to the same epitope as one of the antigen binding proteins described herein, or to an overlapping epitope. Antigen binding proteins and fragments that compete with the exemplified antigen binding proteins are expected to show similar functional properties. The exemplified antigen binding proteins and fragments include those described above, including those with heavy and light chains, variable region domains and CDRs included in TABLES 3, 4A, 4B, and 5. Thus, as a specific example, the antigen binding proteins that are provided include those that compete with an antibody having:

all 6 of the CDRs listed for any antibody listed in TABLES 4A and 4B;

a VH and a VL listed for any antibody listed in TABLE 3; or

two light chains and two heavy chains as specified for any antibody listed in TABLE 5.

The antigen binding proteins that are provided include monoclonal antibodies that bind to GIPR. Monoclonal antibodies may be produced using any technique known in the art, e.g., by immortalizing spleen cells harvested from the transgenic animal after completion of the immunization schedule. The spleen cells can be immortalized using any technique known in the art, e.g., by fusing them with myeloma cells to produce hybridomas. Myeloma cells for use in hybridoma-producing fusion procedures preferably are non-antibody-producing, have high fusion efficiency, and enzyme deficiencies that render them incapable of growing in certain selective media which support the growth of only the desired fused cells (hybridomas). Examples of suitable cell lines for use in mouse fusions include Sp-20, P3-X63/Ag8, P3-X63-Ag8.653, NS1/1.Ag 4 1, Sp210-Ag14, FO, NSO/U, MPC-11, MPC11-X45-GTG 1.7 and 5194/5XXO Bul; examples of cell lines used in rat fusions include R210.RCY3, Y3-Ag 1.2.3, IR983F and 4B210. Other cell lines useful for cell fusions are U-266, GM1500-GRG2, LICR-LON-HMy2 and UC729-6.

In some instances, a hybridoma cell line is produced by immunizing an animal (e.g., a transgenic animal having human immunoglobulin sequences) with a GIPR immunogen; harvesting spleen cells from the immunized animal; fusing the harvested spleen cells to a myeloma cell line, thereby generating hybridoma cells; establishing hybridoma cell lines from the hybridoma cells, and identifying a hybridoma cell line that produces an antibody that binds a GIPR polypeptide. Such hybridoma cell lines, and anti-GIPR monoclonal antibodies produced by them, are aspects of the present application.

Monoclonal antibodies secreted by a hybridoma cell line can be purified using any technique known in the art. Hybridomas or mAbs may be further screened to identify mAbs with particular properties, such as the ability to increase GIPR activity.

Chimeric and humanized antibodies based upon the foregoing sequences are also provided. Monoclonal antibodies for use as therapeutic agents may be modified in various ways prior to use. One example is a chimeric antibody, which is an antibody composed of protein segments from different antibodies that are covalently joined to produce functional immunoglobulin light or heavy chains or immunologically functional portions thereof. Generally, a portion of the heavy chain and/or light chain is identical with or homologous to a corresponding sequence in antibodies derived from a particular species or belonging to a particular antibody class or subclass, while the remainder of the chain(s) is/are identical with or homologous to a corresponding sequence in antibodies derived from another species or belonging to another antibody class or subclass. For methods relating to chimeric antibodies, see, for example, U.S. Pat. No. 4,816,567; and Morrison et al., 1985, Proc. Natl. Acad. Sci. USA 81:6851-6855, which are hereby incorporated by reference. CDR grafting is described, for example, in U.S. Pat. Nos. 6,180,370, 5,693,762, 5,693,761, 5,585,089, and 5,530,101.

Generally, the goal of making a chimeric antibody is to create a chimera in which the number of amino acids from the intended patient species is maximized. One example is the “CDR-grafted” antibody, in which the antibody comprises one or more complementarity determining regions (CDRs) from a particular species or belonging to a particular antibody class or subclass, while the remainder of the antibody chain(s) is/are identical with or homologous to a corresponding sequence in antibodies derived from another species or belonging to another antibody class or subclass. For use in humans, the variable region or selected CDRs from a rodent antibody often are grafted into a human antibody, replacing the naturally-occurring variable regions or CDRs of the human antibody.

One useful type of chimeric antibody is a “humanized” antibody. Generally, a humanized antibody is produced from a monoclonal antibody raised initially in a non-human animal. Certain amino acid residues in this monoclonal antibody, typically from non-antigen recognizing portions of the antibody, are modified to be homologous to corresponding residues in a human antibody of corresponding isotype. Humanization can be performed, for example, using various methods by substituting at least a portion of a rodent variable region for the corresponding regions of a human antibody (see, e.g., U.S. Pat. Nos. 5,585,089, and 5,693,762; Jones et al., 1986, Nature 321:522-525; Riechmann et al., 1988, Nature 332:323-27; Verhoeyen et al., 1988, Science 239:1534-1536).

In one aspect, the CDRs of the light and heavy chain variable regions of the antibodies provided herein are grafted to framework regions (FRs) from antibodies from the same, or a different, phylogenetic species. For example, the CDRs of the heavy and light chain variable regions V_(H)1, V_(H)2, V_(H)3, V_(H)4, V_(H)5, V_(H)6, V_(H)7, V_(H)8, V_(H)9, V_(H)10, V_(H)11, V_(H)12 and/or V_(L)1, and V_(L)2 can be grafted to consensus human FRs. To create consensus human FRs, FRs from several human heavy chain or light chain amino acid sequences may be aligned to identify a consensus amino acid sequence. In other embodiments, the FRs of a heavy chain or light chain disclosed herein are replaced with the FRs from a different heavy chain or light chain. In one aspect, rare amino acids in the FRs of the heavy and light chains of GIPR antibodies are not replaced, while the rest of the FR amino acids are replaced. A “rare amino acid” is a specific amino acid that is in a position in which this particular amino acid is not usually found in an FR. Alternatively, the grafted variable regions from the one heavy or light chain may be used with a constant region that is different from the constant region of that particular heavy or light chain as disclosed herein. In other embodiments, the grafted variable regions are part of a single chain Fv antibody.

In certain embodiments, constant regions from species other than human can be used along with the human variable region(s) to produce hybrid antibodies.

Fully human GIPR antibodies are also provided. Methods are available for making fully human antibodies specific for a given antigen without exposing human beings to the antigen (“fully human antibodies”). One specific means provided for implementing the production of fully human antibodies is the “humanization” of the mouse humoral immune system. Introduction of human immunoglobulin (Ig) loci into mice in which the endogenous Ig genes have been inactivated is one means of producing fully human monoclonal antibodies (mAbs) in mouse, an animal that can be immunized with any desirable antigen. Using fully human antibodies can minimize the immunogenic and allergic responses that can sometimes be caused by administering mouse or mouse-derived mAbs to humans as therapeutic agents.

Fully human antibodies can be produced by immunizing transgenic animals (usually mice) that are capable of producing a repertoire of human antibodies in the absence of endogenous immunoglobulin production. Antigens for this purpose typically have six or more contiguous amino acids, and optionally are conjugated to a carrier, such as a hapten. See, e.g., Jakobovits et al., 1993, Proc. Natl. Acad. Sci. USA 90:2551-2555; Jakobovits et al., 1993, Nature 362:255-258; and Bruggermann et al., 1993, Year in Immunol. 7:33. In one example of such a method, transgenic animals are produced by incapacitating the endogenous mouse immunoglobulin loci encoding the mouse heavy and light immunoglobulin chains therein, and inserting into the mouse genome large fragments of human genome DNA containing loci that encode human heavy and light chain proteins. Partially modified animals, which have less than the full complement of human immunoglobulin loci, are then cross-bred to obtain an animal having all of the desired immune system modifications. When administered an immunogen, these transgenic animals produce antibodies that are immunospecific for the immunogen but have human rather than murine amino acid sequences, including the variable regions. For further details of such methods, see, for example, WO96/33735 and WO94/02602. Additional methods relating to transgenic mice for making human antibodies are described in U.S. Pat. Nos. 5,545,807; 6,713,610; 6,673,986; 6,162,963; 5,545,807; 6,300,129; 6,255,458; 5,877,397; 5,874,299 and 5,545,806; in PCT publications WO91/10741, WO90/04036, and in EP 546073B1 and EP 546073A1.

The transgenic mice described above, referred to herein as “HuMab” mice, contain a human immunoglobulin gene minilocus that encodes unrearranged human heavy ([mu] and [gamma]) and [kappa] light chain immunoglobulin sequences, together with targeted mutations that inactivate the endogenous [mu] and [kappa] chain loci (Lonberg et al., 1994, Nature 368:856-859). Accordingly, the mice exhibit reduced expression of mouse IgM or [kappa] and in response to immunization, and the introduced human heavy and light chain transgenes undergo class switching and somatic mutation to generate high affinity human IgG [kappa] monoclonal antibodies (Lonberg et al., supra.; Lonberg and Huszar, 1995, Intern. Rev. Immunol. 13: 65-93; Harding and Lonberg, 1995, Ann. NY Acad. Sci. 764:536-546). The preparation of HuMab mice is described in detail in Taylor et al., 1992, Nucleic Acids Research 20:6287-6295; Chen et al., 1993, International Immunology 5:647-656; Tuaillon et al., 1994, J Immunol. 152:2912-2920; Lonberg et al., 1994, Nature 368:856-859; Lonberg, 1994, Handbook of Exp. Pharmacology 113:49-101; Taylor et al., 1994, International Immunology 6:579-591; Lonberg and Huszar, 1995, Intern. Rev. Immunol. 13:65-93; Harding and Lonberg, 1995, Ann. NY Acad. Sci. 764:536-546; Fishwild et al., 1996, Nature Biotechnology 14:845-851; the foregoing references are hereby incorporated by reference in their entirety for all purposes. See, further U.S. Pat. Nos. 5,545,806; 5,569,825; 5,625,126; 5,633,425; 5,789,650; 5,877,397; 5,661,016; 5,814,318; 5,874,299; and 5,770,429; as well as U.S. Pat. No. 5,545,807; International Publication Nos. WO 93/1227; WO 92/22646; and WO 92/03918, the disclosures of all of which are hereby incorporated by reference in their entirety for all purposes. Technologies utilized for producing human antibodies in these transgenic mice are disclosed also in WO 98/24893, and Mendez et al., 1997, Nature Genetics 15:146-156, which are hereby incorporated by reference. For example, the HCo7 and HCo12 transgenic mice strains can be used to generate human monoclonal antibodies against GIPR. Further details regarding the production of human antibodies using transgenic mice are provided below.

Using hybridoma technology, antigen-specific human mAbs with the desired specificity can be produced and selected from the transgenic mice such as those described above. Such antibodies may be cloned and expressed using a suitable vector and host cell, or the antibodies can be harvested from cultured hybridoma cells.

Fully human antibodies can also be derived from phage-display libraries (as disclosed in Hoogenboom et al., 1991, J. Mol. Biol. 227:381; and Marks et al., 1991, J. Mol. Biol. 222:581). Phage display techniques mimic immune selection through the display of antibody repertoires on the surface of filamentous bacteriophage, and subsequent selection of phage by their binding to an antigen of choice. One such technique is described in PCT Publication No. WO 99/10494 (hereby incorporated by reference).

The GIPR binding protein can also be a variant, mimetic, derivative or oligomer based upon the structure of GIPR antigen binding proteins have the CDRs, variable regions and/or full length chains as described above.

In one embodiment, for instance, an antigen binding protein is a variant form of the antigen binding proteins disclosed above. For instance, some of the antigen binding proteins have one or more conservative amino acid substitutions in one or more of the heavy or light chains, variable regions or CDRs.

Naturally-occurring amino acids may be divided into classes based on common side chain properties:

1) hydrophobic: norleucine, Met, Ala, Val, Leu, Ile;

2) neutral hydrophilic: Cys, Ser, Thr, Asn, Gln;

3) acidic: Asp, Glu;

4) basic: His, Lys, Arg;

5) residues that influence chain orientation: Gly, Pro; and

6) aromatic: Trp, Tyr, Phe.

Conservative amino acid substitutions may involve exchange of a member of one of these classes with another member of the same class. Conservative amino acid substitutions may encompass non-naturally occurring amino acid residues, which are typically incorporated by chemical peptide synthesis rather than by synthesis in biological systems. These include peptidomimetics and other reversed or inverted forms of amino acid moieties.

Non-conservative substitutions may involve the exchange of a member of one of the above classes for a member from another class. Such substituted residues may be introduced into regions of the antibody that are homologous with human antibodies, or into the non-homologous regions of the molecule.

In making such changes, according to certain embodiments, the hydropathic index of amino acids may be considered. The hydropathic profile of a protein is calculated by assigning each amino acid a numerical value (“hydropathy index”) and then repetitively averaging these values along the peptide chain. Each amino acid has been assigned a hydropathic index on the basis of its hydrophobicity and charge characteristics. They are: isoleucine (+4.5); valine (+4.2); leucine (+3.8); phenylalanine (+2.8); cysteine/cystine (+2.5); methionine (+1.9); alanine (+1.8); glycine (−0.4); threonine (−0.7); serine (−0.8); tryptophan (−0.9); tyrosine (−1.3); proline (−1.6); histidine (−3.2); glutamate (−3.5); glutamine (−3.5); aspartate (−3.5); asparagine (−3.5); lysine (−3.9); and arginine (−4.5).

The importance of the hydropathic profile in conferring interactive biological function on a protein is understood in the art (see, e.g., Kyte et al., 1982, J. Mol. Biol. 157:105-131). It is known that certain amino acids may be substituted for other amino acids having a similar hydropathic index or score and still retain a similar biological activity. In making changes based upon the hydropathic index, in certain embodiments, the substitution of amino acids whose hydropathic indices are within ±2 is included. In some aspects, those which are within ±1 are included, and in other aspects, those within ±0.5 are included.

It is also understood in the art that the substitution of like amino acids can be made effectively on the basis of hydrophilicity, particularly where the biologically functional protein or peptide thereby created is intended for use in immunological embodiments, as in the present case. In certain embodiments, the greatest local average hydrophilicity of a protein, as governed by the hydrophilicity of its adjacent amino acids, correlates with its immunogenicity and antigen-binding or immunogenicity, that is, with a biological property of the protein.

The following hydrophilicity values have been assigned to these amino acid residues: arginine (+3.0); lysine (+3.0); aspartate (+3.0±1); glutamate (+3.0±1); serine (+0.3); asparagine (+0.2); glutamine (+0.2); glycine (0); threonine (−0.4); proline (−0.5±1); alanine (−0.5); histidine (−0.5); cysteine (−1.0); methionine (−1.3); valine (−1.5); leucine (−1.8); isoleucine (−1.8); tyrosine (−2.3); phenylalanine (−2.5) and tryptophan (−3.4). In making changes based upon similar hydrophilicity values, in certain embodiments, the substitution of amino acids whose hydrophilicity values are within ±2 is included, in other embodiments, those which are within ±1 are included, and in still other embodiments, those within ±0.5 are included. In some instances, one may also identify epitopes from primary amino acid sequences on the basis of hydrophilicity. These regions are also referred to as “epitopic core regions.”

Exemplary conservative amino acid substitutions are set forth in Table 6.

TABLE 8 Conservative Amino Acid Substitutions Original Exemplary Residue Substitutions Ala Ser Arg Lys Asn Gln, His Asp Glu Cys Ser Gln Asn Glu Asp Gly Pro His Asn, Gln Ile Leu, Val Leu Ile, Val Lys Arg, Gln, Glu Met Leu, Ile Phe Met, Leu, Tyr Ser Thr Thr Ser Trp Tyr Tyr Trp, Phe Val Ile, Leu

A skilled artisan will be able to determine suitable variants of polypeptides as set forth herein using well-known techniques. One skilled in the art may identify suitable areas of the molecule that may be changed without destroying activity by targeting regions not believed to be important for activity. The skilled artisan also will be able to identify residues and portions of the molecules that are conserved among similar polypeptides. In further embodiments, even areas that may be important for biological activity or for structure may be subject to conservative amino acid substitutions without destroying the biological activity or without adversely affecting the polypeptide structure.

Additionally, one skilled in the art can review structure-function studies identifying residues in similar polypeptides that are important for activity or structure. In view of such a comparison, one can predict the importance of amino acid residues in a protein that correspond to amino acid residues important for activity or structure in similar proteins. One skilled in the art may opt for chemically similar amino acid substitutions for such predicted important amino acid residues.

One skilled in the art can also analyze the 3-dimensional structure and amino acid sequence in relation to that structure in similar polypeptides. In view of such information, one skilled in the art may predict the alignment of amino acid residues of an antibody with respect to its three dimensional structure. One skilled in the art may choose not to make radical changes to amino acid residues predicted to be on the surface of the protein, since such residues may be involved in important interactions with other molecules. Moreover, one skilled in the art may generate test variants containing a single amino acid substitution at each desired amino acid residue. These variants can then be screened using assays for GIPR activity, thus yielding information regarding which amino acids can be changed and which must not be changed. In other words, based on information gathered from such routine experiments, one skilled in the art can readily determine the amino acid positions where further substitutions should be avoided either alone or in combination with other mutations.

A number of scientific publications have been devoted to the prediction of secondary structure. See, Moult, 1996, Curr. Op. in Biotech. 7:422-427; Chou et al., 1974, Biochem. 13:222-245; Chou et al., 1974, Biochemistry 113:211-222; Chou et al., 1978, Adv. Enzymol. Relat. Areas Mol. Biol. 47:45-148; Chou et al., 1979, Ann. Rev. Biochem. 47:251-276; and Chou et al., 1979, Biophys. J. 26:367-384. Moreover, computer programs are currently available to assist with predicting secondary structure. One method of predicting secondary structure is based upon homology modeling. For example, two polypeptides or proteins that have a sequence identity of greater than 30%, or similarity greater than 40% can have similar structural topologies. The recent growth of the protein structural database (PDB) has provided enhanced predictability of secondary structure, including the potential number of folds within a polypeptide's or protein's structure. See, Holm et al., 1999, Nucl. Acid. Res. 27:244-247. It has been suggested (Brenner et al., 1997, Curr. Op. Struct. Biol. 7:369-376) that there are a limited number of folds in a given polypeptide or protein and that once a critical number of structures have been resolved, structural prediction will become dramatically more accurate.

Additional methods of predicting secondary structure include “threading” (Jones, 1997, Curr. Opin. Struct. Biol. 7:377-387; Sippl et al., 1996, Structure 4:15-19), “profile analysis” (Bowie et al., 1991, Science 253:164-170; Gribskov et al., 1990, Meth. Enzym. 183:146-159; Gribskov et al., 1987, Proc. Nat. Acad. Sci. 84:4355-4358), and “evolutionary linkage” (See, Holm, 1999, supra; and Brenner, 1997, supra).

In some embodiments, amino acid substitutions are made that: (1) reduce susceptibility to proteolysis, (2) reduce susceptibility to oxidation, (3) alter binding affinity for forming protein complexes, (4) alter ligand or antigen binding affinities, and/or (4) confer or modify other physicochemical or functional properties on such polypeptides. For example, single or multiple amino acid substitutions (in certain embodiments, conservative amino acid substitutions) may be made in the naturally-occurring sequence. Substitutions can be made in that portion of the antibody that lies outside the domain(s) forming intermolecular contacts). In such embodiments, conservative amino acid substitutions can be used that do not substantially change the structural characteristics of the parent sequence (e.g., one or more replacement amino acids that do not disrupt the secondary structure that characterizes the parent or native antigen binding protein). Examples of art-recognized polypeptide secondary and tertiary structures are described in Proteins, Structures and Molecular Principles (Creighton, Ed.), 1984, W. H. New York: Freeman and Company; Introduction to Protein Structure (Branden and Tooze, eds.), 1991, New York: Garland Publishing; and Thornton et al., 1991, Nature 354:105, which are each incorporated herein by reference.

Additional preferred antibody variants include cysteine variants wherein one or more cysteine residues in the parent or native amino acid sequence are deleted from or substituted with another amino acid (e.g., serine). Cysteine variants are useful, inter alia when antibodies must be refolded into a biologically active conformation. Cysteine variants may have fewer cysteine residues than the native antibody, and typically have an even number to minimize interactions resulting from unpaired cysteines.

The heavy and light chains, variable regions domains and CDRs that are disclosed can be used to prepare polypeptides that contain an antigen binding region that can specifically bind to GIPR. For example, one or more of the CDRs can be incorporated into a molecule (e.g., a polypeptide) covalently or noncovalently to make an immunoadhesion. An immunoadhesion may incorporate the CDR(s) as part of a larger polypeptide chain, may covalently link the CDR(s) to another polypeptide chain, or may incorporate the CDR(s) noncovalently. The CDR(s) enable the immunoadhesion to bind specifically to a particular antigen of interest (e.g., an GIPR polypeptide or epitope thereof).

Mimetics (e.g., “peptide mimetics” or “peptidomimetics”) based upon the variable region domains and CDRs that are described herein are also provided. These analogs can be peptides, non-peptides or combinations of peptide and non-peptide regions. Fauchere, 1986, Adv. Drug Res. 15:29; Veber and Freidinger, 1985, TINS p. 392; and Evans et al., 1987, J. Med. Chem. 30:1229, which are incorporated herein by reference for any purpose. Peptide mimetics that are structurally similar to therapeutically useful peptides may be used to produce a similar therapeutic or prophylactic effect. Such compounds are often developed with the aid of computerized molecular modeling. Generally, peptidomimetics are proteins that are structurally similar to an antibody displaying a desired biological activity, such as here the ability to specifically bind GIPR, but have one or more peptide linkages optionally replaced by a linkage selected from: —CH₂NH—, —CH₂S—, —CH₂—CH₂—, —CH—CH-(cis and trans), —COCH₂—, —CH(OH)CH₂—, and —CH₂SO—, by methods well known in the art. Systematic substitution of one or more amino acids of a consensus sequence with a D-amino acid of the same type (e.g., D-lysine in place of L-lysine) may be used in certain embodiments to generate more stable proteins. In addition, constrained peptides comprising a consensus sequence or a substantially identical consensus sequence variation may be generated by methods known in the art (Rizo and Gierasch, 1992, Ann. Rev. Biochem. 61:387), incorporated herein by reference), for example, by adding internal cysteine residues capable of forming intramolecular disulfide bridges which cyclize the peptide.

Derivatives of the antigen binding proteins that are described herein are also provided. The derivatized antigen binding proteins can comprise any molecule or substance that imparts a desired property to the antibody or fragment, such as increased half-life in a particular use. The derivatized antigen binding protein can comprise, for example, a detectable (or labeling) moiety (e.g., a radioactive, colorimetric, antigenic or enzymatic molecule, a detectable bead (such as a magnetic or electrodense (e.g., gold) bead), or a molecule that binds to another molecule (e.g., biotin or streptavidin)), a therapeutic or diagnostic moiety (e.g., a radioactive, cytotoxic, or pharmaceutically active moiety), or a molecule that increases the suitability of the antigen binding protein for a particular use (e.g., administration to a subject, such as a human subject, or other in vivo or in vitro uses). Examples of molecules that can be used to derivatize an antigen binding protein include albumin (e.g., human serum albumin) and polyethylene glycol (PEG). Albumin-linked and PEGylated derivatives of antigen binding proteins can be prepared using techniques well known in the art. Certain antigen binding proteins include a pegylated single chain polypeptide as described herein. In one embodiment, the antigen binding protein is conjugated or otherwise linked to transthyretin (TTR) or a TTR variant. The TTR or TTR variant can be chemically modified with, for example, a chemical selected from the group consisting of dextran, poly(n-vinyl pyrrolidone), polyethylene glycols, propropylene glycol homopolymers, polypropylene oxide/ethylene oxide co-polymers, polyoxyethylated polyols and polyvinyl alcohols.

Other derivatives include covalent or aggregative conjugates of GIPR antigen binding proteins with other proteins or polypeptides, such as by expression of recombinant fusion proteins comprising heterologous polypeptides fused to the N-terminus or C-terminus of an GIPR antigen binding protein. For example, the conjugated peptide may be a heterologous signal (or leader) polypeptide, e.g., the yeast alpha-factor leader, or a peptide such as an epitope tag. GIPR antigen binding protein-containing fusion proteins can comprise peptides added to facilitate purification or identification of the GIPR antigen binding protein (e.g., poly-His). A GIPR antigen binding protein also can be linked to the FLAG peptide as described in Hopp et al., 1988, Bio/Technology 6:1204; and U.S. Pat. No. 5,011,912. The FLAG peptide is highly antigenic and provides an epitope reversibly bound by a specific monoclonal antibody (mAb), enabling rapid assay and facile purification of expressed recombinant protein. Reagents useful for preparing fusion proteins in which the FLAG peptide is fused to a given polypeptide are commercially available (Sigma, St. Louis, Mo.).

In some embodiments, the antigen binding protein comprises one or more labels. The term “labeling group” or “label” means any detectable label. Examples of suitable labeling groups include, but are not limited to, the following: radioisotopes or radionuclides (e.g., ³H, ¹⁵C, ¹⁵N, ³⁵S, ⁹⁰Y, ⁹⁹Tc, ¹¹¹In, ¹²⁵I, ¹³¹I), fluorescent groups (e.g., FITC, rhodamine, lanthanide phosphors), enzymatic groups (e.g., horseradish peroxidase, β-galactosidase, luciferase, alkaline phosphatase), chemiluminescent groups, biotinyl groups, or predetermined polypeptide epitopes recognized by a secondary reporter (e.g., leucine zipper pair sequences, binding sites for secondary antibodies, metal binding domains, epitope tags). In some embodiments, the labeling group is coupled to the antigen binding protein via spacer arms of various lengths to reduce potential steric hindrance. Various methods for labeling proteins are known in the art and may be used as is seen fit.

The term “effector group” means any group coupled to an antigen binding protein that acts as a cytotoxic agent. Examples for suitable effector groups are radioisotopes or radionuclides (e.g., ³H, ¹⁴C, ¹⁵N, ³⁵S, ⁹⁰Y, ⁹⁹Tc, ¹¹¹In, ¹²⁵I, ¹³¹I). Other suitable groups include toxins, therapeutic groups, or chemotherapeutic groups. Examples of suitable groups include calicheamicin, auristatins, geldanamycin and maytansine. In some embodiments, the effector group is coupled to the antigen binding protein via spacer arms of various lengths to reduce potential steric hindrance.

In general, labels fall into a variety of classes, depending on the assay in which they are to be detected: a) isotopic labels, which may be radioactive or heavy isotopes; b) magnetic labels (e.g., magnetic particles); c) redox active moieties; d) optical dyes; enzymatic groups (e.g. horseradish peroxidase, β-galactosidase, luciferase, alkaline phosphatase); e) biotinylated groups; and f) predetermined polypeptide epitopes recognized by a secondary reporter (e.g., leucine zipper pair sequences, binding sites for secondary antibodies, metal binding domains, epitope tags, etc.). In some embodiments, the labeling group is coupled to the antigen binding protein via spacer arms of various lengths to reduce potential steric hindrance. Various methods for labeling proteins are known in the art.

Specific labels include optical dyes, including, but not limited to, chromophores, phosphors and fluorophores, with the latter being specific in many instances. Fluorophores can be either “small molecule” fluores, or proteinaceous fluores.

By “fluorescent label” is meant any molecule that may be detected via its inherent fluorescent properties. Suitable fluorescent labels include, but are not limited to, fluorescein, rhodamine, tetramethylrhodamine, eosin, erythrosin, coumarin, methyl-coumarins, pyrene, Malacite green, stilbene, Lucifer Yellow, Cascade BlueJ, Texas Red, IAEDANS, EDANS, BODIPY FL, LC Red 640, Cy 5, Cy 5.5, LC Red 705, Oregon green, the Alexa-Fluor dyes (Alexa Fluor 350, Alexa Fluor 430, Alexa Fluor 488, Alexa Fluor 546, Alexa Fluor 568, Alexa Fluor 594, Alexa Fluor 633, Alexa Fluor 660, Alexa Fluor 680), Cascade Blue, Cascade Yellow and R-phycoerythrin (PE) (Molecular Probes, Eugene, Oreg.), FITC, Rhodamine, and Texas Red (Pierce, Rockford, Ill.), Cy5, Cy5.5, Cy7 (Amersham Life Science, Pittsburgh, Pa.). Suitable optical dyes, including fluorophores, are described in Molecular Probes Handbook by Richard P. Haugland, hereby expressly incorporated by reference.

Suitable proteinaceous fluorescent labels also include, but are not limited to, green fluorescent protein, including a Renilla, Ptilosarcus, or Aequorea species of GFP (Chalfie et al., 1994, Science 263:802-805), EGFP (Clontech Labs., Inc., Genbank Accession Number U55762), blue fluorescent protein (BFP, Quantum Biotechnologies, Inc., Quebec, Canada; Stauber, 1998, Biotechniques 24:462-471; Heim et al., 1996, Curr. Biol. 6:178-182), enhanced yellow fluorescent protein (EYFP, Clontech Labs., Inc.), luciferase (Ichiki et al., 1993, J. Immunol. 150:5408-5417), β galactosidase (Nolan et al., 1988, Proc. Natl. Acad. Sci. U.S.A. 85:2603-2607) and Renilla (WO92/15673, WO95/07463, WO98/14605, WO98/26277, WO99/49019, U.S. Pat. Nos. 5,292,658, 5,418,155, 5,683,888, 5,741,668, 5,777,079, 5,804,387, 5,874,304, 5,876,995, 5,925,558).

Nucleic acids that encode for the antigen binding proteins described herein, or portions thereof, are also provided, including nucleic acids encoding one or both chains of an antibody, or a fragment, derivative, mutein, or variant thereof, polynucleotides encoding heavy chain variable regions or only CDRs, polynucleotides sufficient for use as hybridization probes, PCR primers or sequencing primers for identifying, analyzing, mutating or amplifying a polynucleotide encoding a polypeptide, anti-sense nucleic acids for inhibiting expression of a polynucleotide, and complementary sequences of the foregoing. The nucleic acids can be any length. They can be, for example, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 75, 100, 125, 150, 175, 200, 250, 300, 350, 400, 450, 500, 750, 1,000, 1,500, 3,000, 5,000 or more nucleotides in length, and/or can comprise one or more additional sequences, for example, regulatory sequences, and/or be part of a larger nucleic acid, for example, a vector. The nucleic acids can be single-stranded or double-stranded and can comprise RNA and/or DNA nucleotides, and artificial variants thereof (e.g., peptide nucleic acids). Any variable region provided herein may be attached to these constant regions to form complete heavy and light chain sequences. However, it should be understood that these constant regions sequences are provided as specific examples only. In some embodiments, the variable region sequences are joined to other constant region sequences that are known in the art.

Nucleic acids encoding certain antigen binding proteins, or portions thereof (e.g., full length antibody, heavy or light chain, variable domain, or CDRH1, CDRH2, CDRH3, CDRL1, CDRL2, or CDRL3) may be isolated from B-cells of mice that have been immunized with GIPR or an immunogenic fragment thereof. The nucleic acid may be isolated by conventional procedures such as polymerase chain reaction (PCR). Phage display is another example of a known technique whereby derivatives of antibodies and other antigen binding proteins may be prepared. In one approach, polypeptides that are components of an antigen binding protein of interest are expressed in any suitable recombinant expression system, and the expressed polypeptides are allowed to assemble to form antigen binding proteins.

An aspect further provides nucleic acids that hybridize to other nucleic acids under particular hybridization conditions. Methods for hybridizing nucleic acids are well-known in the art. See, e.g., Current Protocols in Molecular Biology, John Wiley & Sons, N.Y. (1989), 6.3.1-6.3.6. As defined herein, a moderately stringent hybridization condition uses a prewashing solution containing 5× sodium chloride/sodium citrate (SSC), 0.5% SDS, 1.0 mM EDTA (pH 8.0), hybridization buffer of about 50% formamide, 6×SSC, and a hybridization temperature of 55° C. (or other similar hybridization solutions, such as one containing about 50% formamide, with a hybridization temperature of 42° C.), and washing conditions of 60° C., in 0.5×SSC, 0.1% SDS. A stringent hybridization condition hybridizes in 6×SSC at 45° C., followed by one or more washes in 0.1×SSC, 0.2% SDS at 68° C. Furthermore, one of skill in the art can manipulate the hybridization and/or washing conditions to increase or decrease the stringency of hybridization such that nucleic acids comprising nucleotide sequences that are at least 65%, 70%, 75%, 80%, 85%, 90%, 95%, 98% or 99% identical to each other typically remain hybridized to each other.

The basic parameters affecting the choice of hybridization conditions and guidance for devising suitable conditions are set forth by, for example, Sambrook, Fritsch, and Maniatis (2001, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., supra; and Current Protocols in Molecular Biology, 1995, Ausubel et al., eds., John Wiley & Sons, Inc., sections 2.10 and 6.3-6.4), and can be readily determined by those having ordinary skill in the art based on, e.g., the length and/or base composition of the nucleic acid.

Changes can be introduced by mutation into a nucleic acid, thereby leading to changes in the amino acid sequence of a polypeptide (e.g., an antibody or antibody derivative) that it encodes. Mutations can be introduced using any technique known in the art. In one embodiment, one or more particular amino acid residues are changed using, for example, a site-directed mutagenesis protocol. In another embodiment, one or more randomly selected residues is changed using, for example, a random mutagenesis protocol. However it is made, a mutant polypeptide can be expressed and screened for a desired property.

Mutations can be introduced into a nucleic acid without significantly altering the biological activity of a polypeptide that it encodes. For example, one can make nucleotide substitutions leading to amino acid substitutions at non-essential amino acid residues. Alternatively, one or more mutations can be introduced into a nucleic acid that selectively changes the biological activity of a polypeptide that it encodes. For example, the mutation can quantitatively or qualitatively change the biological activity. Examples of quantitative changes include increasing, reducing or eliminating the activity. Examples of qualitative changes include changing the antigen specificity of an antibody. In one embodiment, a nucleic acid encoding any antigen binding protein described herein can be mutated to alter the amino acid sequence using molecular biology techniques that are well-established in the art.

Another aspect provides nucleic acid molecules that are suitable for use as primers or hybridization probes for the detection of nucleic acid sequences. A nucleic acid molecule can comprise only a portion of a nucleic acid sequence encoding a full-length polypeptide, for example, a fragment that can be used as a probe or primer or a fragment encoding an active portion of a polypeptide.

Probes based on the sequence of a nucleic acid can be used to detect the nucleic acid or similar nucleic acids, for example, transcripts encoding a polypeptide. The probe can comprise a label group, e.g., a radioisotope, a fluorescent compound, an enzyme, or an enzyme co-factor. Such probes can be used to identify a cell that expresses the polypeptide.

Another aspect provides vectors comprising a nucleic acid encoding a polypeptide or a portion thereof (e.g., a fragment containing one or more CDRs or one or more variable region domains). Examples of vectors include, but are not limited to, plasmids, viral vectors, non-episomal mammalian vectors and expression vectors, for example, recombinant expression vectors. The recombinant expression vectors can comprise a nucleic acid in a form suitable for expression of the nucleic acid in a host cell. The recombinant expression vectors include one or more regulatory sequences, selected on the basis of the host cells to be used for expression, which is operably linked to the nucleic acid sequence to be expressed. Regulatory sequences include those that direct constitutive expression of a nucleotide sequence in many types of host cells (e.g., SV40 early gene enhancer, Rous sarcoma virus promoter and cytomegalovirus promoter), those that direct expression of the nucleotide sequence only in certain host cells (e.g., tissue-specific regulatory sequences, see, Voss et al., 1986, Trends Biochem. Sci. 11:287, Maniatis et al., 1987, Science 236:1237, incorporated by reference herein in their entireties), and those that direct inducible expression of a nucleotide sequence in response to particular treatment or condition (e.g., the metallothionin promoter in mammalian cells and the tet-responsive and/or streptomycin responsive promoter in both prokaryotic and eukaryotic systems (see, id.). It will be appreciated by those skilled in the art that the design of the expression vector can depend on such factors as the choice of the host cell to be transformed, the level of expression of protein desired, etc. The expression vectors can be introduced into host cells to thereby produce proteins or peptides, including fusion proteins or peptides, encoded by nucleic acids as described herein.

Another aspect provides host cells into which a recombinant expression vector has been introduced. A host cell can be any prokaryotic cell (for example, E. coli) or eukaryotic cell (for example, yeast, insect, or mammalian cells (e.g., CHO cells)). Vector DNA can be introduced into prokaryotic or eukaryotic cells via conventional transformation or transfection techniques. For stable transfection of mammalian cells, it is known that, depending upon the expression vector and transfection technique used, only a small fraction of cells may integrate the foreign DNA into their genome. In order to identify and select these integrants, a gene that encodes a selectable marker (e.g., for resistance to antibiotics) is generally introduced into the host cells along with the gene of interest. Preferred selectable markers include those which confer resistance to drugs, such as G418, hygromycin and methotrexate. Cells stably transfected with the introduced nucleic acid can be identified by drug selection (e.g., cells that have incorporated the selectable marker gene will survive, while the other cells die), among other methods.

Expression systems and constructs in the form of plasmids, expression vectors, transcription or expression cassettes that comprise at least one polynucleotide as described above are also provided herein, as well host cells comprising such expression systems or constructs.

The antigen binding proteins provided herein may be prepared by any of a number of conventional techniques. For example, GIPR antigen binding proteins may be produced by recombinant expression systems, using any technique known in the art. See, e.g., Monoclonal Antibodies, Hybridomas: A New Dimension in Biological Analyses, Kennet et al. (eds.) Plenum Press, New York (1980); and Antibodies: A Laboratory Manual, Harlow and Lane (eds.), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y. (1988).

Antigen binding proteins can be expressed in hybridoma cell lines (e.g., in particular antibodies may be expressed in hybridomas) or in cell lines other than hybridomas. Expression constructs encoding the antibodies can be used to transform a mammalian, insect or microbial host cell. Transformation can be performed using any known method for introducing polynucleotides into a host cell, including, for example packaging the polynucleotide in a virus or bacteriophage and transducing a host cell with the construct by transfection procedures known in the art, as exemplified by U.S. Pat. Nos. 4,399,216; 4,912,040; 4,740,461; 4,959,455. The optimal transformation procedure used will depend upon which type of host cell is being transformed. Methods for introduction of heterologous polynucleotides into mammalian cells are well known in the art and include, but are not limited to, dextran-mediated transfection, calcium phosphate precipitation, polybrene mediated transfection, protoplast fusion, electroporation, encapsulation of the polynucleotide(s) in liposomes, mixing nucleic acid with positively-charged lipids, and direct microinjection of the DNA into nuclei.

Recombinant expression constructs typically comprise a nucleic acid molecule encoding a polypeptide comprising one or more of the following: one or more CDRs provided herein; a light chain constant region; a light chain variable region; a heavy chain constant region (e.g., CH1, CH₂ and/or CH3); and/or another scaffold portion of a GIPR antigen binding protein. These nucleic acid sequences are inserted into an appropriate expression vector using standard ligation techniques. In one embodiment, the heavy or light chain constant region is appended to the C-terminus of the anti-GIPR specific heavy or light chain variable region and is ligated into an expression vector. The vector is typically selected to be functional in the particular host cell employed (i.e., the vector is compatible with the host cell machinery, permitting amplification and/or expression of the gene can occur). In some embodiments, vectors are used that employ protein-fragment complementation assays using protein reporters, such as dihydrofolate reductase (see, for example, U.S. Pat. No. 6,270,964, which is hereby incorporated by reference). Suitable expression vectors can be purchased, for example, from Invitrogen Life Technologies or BD Biosciences (formerly “Clontech”). Other useful vectors for cloning and expressing the antibodies and fragments include those described in Bianchi and McGrew, 2003, Biotech. Biotechnol. Bioeng. 84:439-44, which is hereby incorporated by reference. Additional suitable expression vectors are discussed, for example, in Methods Enzymol., vol. 185 (D. V. Goeddel, ed.), 1990, New York: Academic Press.

Typically, expression vectors used in any of the host cells will contain sequences for plasmid maintenance and for cloning and expression of exogenous nucleotide sequences. Such sequences, collectively referred to as “flanking sequences” in certain embodiments will typically include one or more of the following nucleotide sequences: a promoter, one or more enhancer sequences, an origin of replication, a transcriptional termination sequence, a complete intron sequence containing a donor and acceptor splice site, a sequence encoding a leader sequence for polypeptide secretion, a ribosome binding site, a polyadenylation sequence, a polylinker region for inserting the nucleic acid encoding the polypeptide to be expressed, and a selectable marker element. Each of these sequences is discussed below.

Optionally, the vector may contain a “tag”-encoding sequence, i.e., an oligonucleotide molecule located at the 5′ or 3′ end of the GIPR antigen binding protein coding sequence; the oligonucleotide sequence encodes polyHis (such as hexaHis), or another “tag” such as FLAG®, HA (hemaglutinin influenza virus), or myc, for which commercially available antibodies exist. This tag is typically fused to the polypeptide upon expression of the polypeptide, and can serve as a means for affinity purification or detection of the GIPR antigen binding protein from the host cell. Affinity purification can be accomplished, for example, by column chromatography using antibodies against the tag as an affinity matrix. Optionally, the tag can subsequently be removed from the purified GIPR antigen binding protein by various means such as using certain peptidases for cleavage.

Flanking sequences may be homologous (i.e., from the same species and/or strain as the host cell), heterologous (i.e., from a species other than the host cell species or strain), hybrid (i.e., a combination of flanking sequences from more than one source), synthetic or native. As such, the source of a flanking sequence may be any prokaryotic or eukaryotic organism, any vertebrate or invertebrate organism, or any plant, provided that the flanking sequence is functional in, and can be activated by, the host cell machinery.

Flanking sequences useful in the vectors may be obtained by any of several methods well known in the art. Typically, flanking sequences useful herein will have been previously identified by mapping and/or by restriction endonuclease digestion and can thus be isolated from the proper tissue source using the appropriate restriction endonucleases. In some cases, the full nucleotide sequence of a flanking sequence may be known. Here, the flanking sequence may be synthesized using the methods described herein for nucleic acid synthesis or cloning.

Whether all or only a portion of the flanking sequence is known, it may be obtained using polymerase chain reaction (PCR) and/or by screening a genomic library with a suitable probe such as an oligonucleotide and/or flanking sequence fragment from the same or another species. Where the flanking sequence is not known, a fragment of DNA containing a flanking sequence may be isolated from a larger piece of DNA that may contain, for example, a coding sequence or even another gene or genes. Isolation may be accomplished by restriction endonuclease digestion to produce the proper DNA fragment followed by isolation using agarose gel purification, Qiagen® column chromatography (Chatsworth, Calif.), or other methods known to the skilled artisan. The selection of suitable enzymes to accomplish this purpose will be readily apparent to one of ordinary skill in the art.

An origin of replication is typically a part of those prokaryotic expression vectors purchased commercially, and the origin aids in the amplification of the vector in a host cell. If the vector of choice does not contain an origin of replication site, one may be chemically synthesized based on a known sequence, and ligated into the vector. For example, the origin of replication from the plasmid pBR322 (New England Biolabs, Beverly, Mass.) is suitable for most gram-negative bacteria, and various viral origins (e.g., SV40, polyoma, adenovirus, vesicular stomatitus virus (VSV), or papillomaviruses such as HPV or BPV) are useful for cloning vectors in mammalian cells. Generally, the origin of replication component is not needed for mammalian expression vectors (for example, the SV40 origin is often used only because it also contains the virus early promoter).

A transcription termination sequence is typically located 3′ to the end of a polypeptide coding region and serves to terminate transcription. Usually, a transcription termination sequence in prokaryotic cells is a G-C rich fragment followed by a poly-T sequence. While the sequence is easily cloned from a library or even purchased commercially as part of a vector, it can also be readily synthesized using methods for nucleic acid synthesis such as those described herein.

A selectable marker gene encodes a protein necessary for the survival and growth of a host cell grown in a selective culture medium. Typical selection marker genes encode proteins that (a) confer resistance to antibiotics or other toxins, e.g., ampicillin, tetracycline, or kanamycin for prokaryotic host cells; (b) complement auxotrophic deficiencies of the cell; or (c) supply critical nutrients not available from complex or defined media. Specific selectable markers are the kanamycin resistance gene, the ampicillin resistance gene, and the tetracycline resistance gene. Advantageously, a neomycin resistance gene may also be used for selection in both prokaryotic and eukaryotic host cells.

Other selectable genes may be used to amplify the gene that will be expressed. Amplification is the process wherein genes that are required for production of a protein critical for growth or cell survival are reiterated in tandem within the chromosomes of successive generations of recombinant cells. Examples of suitable selectable markers for mammalian cells include dihydrofolate reductase (DHFR) and promoterless thymidine kinase genes. Mammalian cell transformants are placed under selection pressure wherein only the transformants are uniquely adapted to survive by virtue of the selectable gene present in the vector. Selection pressure is imposed by culturing the transformed cells under conditions in which the concentration of selection agent in the medium is successively increased, thereby leading to the amplification of both the selectable gene and the DNA that encodes another gene, such as an antigen binding protein that binds GIPR polypeptide. As a result, increased quantities of a polypeptide such as an antigen binding protein are synthesized from the amplified DNA.

A ribosome-binding site is usually necessary for translation initiation of mRNA and is characterized by a Shine-Dalgarno sequence (prokaryotes) or a Kozak sequence (eukaryotes). The element is typically located 3′ to the promoter and 5′ to the coding sequence of the polypeptide to be expressed.

In some cases, such as where glycosylation is desired in a eukaryotic host cell expression system, one may manipulate the various pre- or pro-sequences to improve glycosylation or yield. For example, one may alter the peptidase cleavage site of a particular signal peptide, or add prosequences, which also may affect glycosylation. The final protein product may have, in the −1 position (relative to the first amino acid of the mature protein), one or more additional amino acids incident to expression, which may not have been totally removed. For example, the final protein product may have one or two amino acid residues found in the peptidase cleavage site, attached to the amino-terminus. Alternatively, use of some enzyme cleavage sites may result in a slightly truncated form of the desired polypeptide, if the enzyme cuts at such area within the mature polypeptide.

Expression and cloning will typically contain a promoter that is recognized by the host organism and operably linked to the molecule encoding the GIPR antigen binding protein. Promoters are untranscribed sequences located upstream (i.e., 5′) to the start codon of a structural gene (generally within about 100 to 1000 bp) that control transcription of the structural gene. Promoters are conventionally grouped into one of two classes: inducible promoters and constitutive promoters. Inducible promoters initiate increased levels of transcription from DNA under their control in response to some change in culture conditions, such as the presence or absence of a nutrient or a change in temperature. Constitutive promoters, on the other hand, uniformly transcribe a gene to which they are operably linked, that is, with little or no control over gene expression. A large number of promoters, recognized by a variety of potential host cells, are well known. A suitable promoter is operably linked to the DNA encoding heavy chain or light chain comprising a GIPR antigen binding protein by removing the promoter from the source DNA by restriction enzyme digestion and inserting the desired promoter sequence into the vector.

Suitable promoters for use with yeast hosts are also well known in the art. Yeast enhancers are advantageously used with yeast promoters. Suitable promoters for use with mammalian host cells are well known and include, but are not limited to, those obtained from the genomes of viruses such as polyoma virus, fowlpox virus, adenovirus (such as Adenovirus 2), bovine papilloma virus, avian sarcoma virus, cytomegalovirus, retroviruses, hepatitis-B virus, and Simian Virus 40 (SV40). Other suitable mammalian promoters include heterologous mammalian promoters, for example, heat-shock promoters and the actin promoter.

An enhancer sequence may be inserted into the vector to increase transcription of DNA encoding light chain or heavy chain comprising a GIPR antigen binding protein by higher eukaryotes. Enhancers are cis-acting elements of DNA, usually about 10-300 bp in length, that act on the promoter to increase transcription. Enhancers are relatively orientation and position independent, having been found at positions both 5′ and 3′ to the transcription unit. Several enhancer sequences available from mammalian genes are known (e.g., globin, elastase, albumin, alpha-feto-protein and insulin). Typically, however, an enhancer from a virus is used. The SV40 enhancer, the cytomegalovirus early promoter enhancer, the polyoma enhancer, and adenovirus enhancers known in the art are exemplary enhancing elements for the activation of eukaryotic promoters. While an enhancer may be positioned in the vector either 5′ or 3′ to a coding sequence, it is typically located at a site 5′ from the promoter. A sequence encoding an appropriate native or heterologous signal sequence (leader sequence or signal peptide) can be incorporated into an expression vector, to promote extracellular secretion of the antibody. The choice of signal peptide or leader depends on the type of host cells in which the antibody is to be produced, and a heterologous signal sequence can replace the native signal sequence. Examples of signal peptides that are functional in mammalian host cells include the following: the signal sequence for interleukin-7 (IL-7) described in U.S. Pat. No. 4,965,195; the signal sequence for interleukin-2 receptor described in Cosman et al., 1984, Nature 312:768; the interleukin-4 receptor signal peptide described in EP Patent No. 0367 566; the type I interleukin-1 receptor signal peptide described in U.S. Pat. No. 4,968,607; the type II interleukin-1 receptor signal peptide described in EP Patent No. 0 460 846.

In one embodiment the leader sequence comprises SEQ ID NO: 3157 (MDMRVPAQLL GLLLLWLRGA RC) which is encoded by SEQ ID NO: 3158 (atggacatga gagtgcctgc acagctgctg ggcctgctgc tgctgtggct gagaggcgcc agatgc).

In another embodiment the leader sequence comprises SEQ ID NO: 3159 (MAWALLLLTL LTQGTGSWA) which is encoded by SEQ ID NO: 3160 (atggcctggg ctctgctgct cctcaccctc ctcactcagg gcacagggtc ctgggcc).

The expression vectors that are provided may be constructed from a starting vector such as a commercially available vector. Such vectors may or may not contain all of the desired flanking sequences. Where one or more of the flanking sequences described herein are not already present in the vector, they may be individually obtained and ligated into the vector. Methods used for obtaining each of the flanking sequences are well known to one skilled in the art.

After the vector has been constructed and a nucleic acid molecule encoding light chain, a heavy chain, or a light chain and a heavy chain comprising a GIPR antigen binding sequence has been inserted into the proper site of the vector, the completed vector may be inserted into a suitable host cell for amplification and/or polypeptide expression. The transformation of an expression vector for an antigen-binding protein into a selected host cell may be accomplished by well-known methods including transfection, infection, calcium phosphate co-precipitation, electroporation, microinjection, lipofection, DEAE-dextran mediated transfection, or other known techniques. The method selected will in part be a function of the type of host cell to be used. These methods and other suitable methods are well known to the skilled artisan, and are set forth, for example, in Sambrook et al., 2001, supra.

A host cell, when cultured under appropriate conditions, synthesizes an antigen binding protein that can subsequently be collected from the culture medium (if the host cell secretes it into the medium) or directly from the host cell producing it (if it is not secreted). The selection of an appropriate host cell will depend upon various factors, such as desired expression levels, polypeptide modifications that are desirable or necessary for activity (such as glycosylation or phosphorylation) and ease of folding into a biologically active molecule.

Mammalian cell lines available as hosts for expression are well known in the art and include, but are not limited to, immortalized cell lines available from the American Type Culture Collection (ATCC), including but not limited to Chinese hamster ovary (CHO) cells, HeLa cells, baby hamster kidney (BHK) cells, monkey kidney cells (COS), human hepatocellular carcinoma cells (e.g., Hep G2), and a number of other cell lines. In certain embodiments, cell lines may be selected through determining which cell lines have high expression levels and constitutively produce antigen binding proteins with GIPR binding properties. In another embodiment, a cell line from the B cell lineage that does not make its own antibody but has a capacity to make and secrete a heterologous antibody can be selected.

In one embodiment, the present invention is directed to an antigen binding protein produced by a cell expressing one or more of the polynucleotides identified in Tables 2, 3, 4, and 5.

In one aspect, a GIPR binding protein is administered for chronic treatment. In another aspect, the binding proteins are administered for acute therapy.

Pharmaceutical compositions that comprise a GIPR antigen binding protein are also provided and can be utilized in any of the preventive and therapeutic methods disclosed herein. In an embodiment, a therapeutically effective amount of one or a plurality of the antigen binding proteins and a pharmaceutically acceptable diluent, carrier, solubilizer, emulsifier, preservative, and/or adjuvant are also provided. Acceptable formulation materials are nontoxic to recipients at the dosages and concentrations employed.

In certain embodiments, the pharmaceutical composition may contain formulation materials for modifying, maintaining or preserving, for example, the pH, osmolarity, viscosity, clarity, color, isotonicity, odor, sterility, stability, rate of dissolution or release, adsorption or penetration of the composition. In such embodiments, suitable formulation materials include, but are not limited to, amino acids (such as glycine, glutamine, asparagine, arginine or lysine); antimicrobials; antioxidants (such as ascorbic acid, sodium sulfite or sodium hydrogen-sulfite); buffers (such as borate, bicarbonate, Tris-HCl, citrates, phosphates or other organic acids); bulking agents (such as mannitol or glycine); chelating agents (such as ethylenediamine tetraacetic acid (EDTA)); complexing agents (such as caffeine, polyvinylpyrrolidone, beta-cyclodextrin or hydroxypropyl-beta-cyclodextrin); fillers; monosaccharides; disaccharides; and other carbohydrates (such as glucose, mannose or dextrins); proteins (such as serum albumin, gelatin or immunoglobulins); coloring, flavoring and diluting agents; emulsifying agents; hydrophilic polymers (such as polyvinylpyrrolidone); low molecular weight polypeptides; salt-forming counterions (such as sodium); preservatives (such as benzalkonium chloride, benzoic acid, salicylic acid, thimerosal, phenethyl alcohol, methylparaben, propylparaben, chlorhexidine, sorbic acid or hydrogen peroxide); solvents (such as glycerin, propylene glycol or polyethylene glycol); sugar alcohols (such as mannitol or sorbitol); suspending agents; surfactants or wetting agents (such as pluronics, PEG, sorbitan esters, polysorbates such as polysorbate 20, polysorbate, triton, tromethamine, lecithin, cholesterol, tyloxapal); stability enhancing agents (such as sucrose or sorbitol); tonicity enhancing agents (such as alkali metal halides, preferably sodium or potassium chloride, mannitol sorbitol); delivery vehicles; diluents; excipients and/or pharmaceutical adjuvants. REMINGTON'S PHARMACEUTICAL SCIENCES, 18″ Edition, (A. R. Genrmo, ed.), 1990, Mack Publishing Company provides additional details and options for suitable agents that can be incorporated into the pharmaceutical compositions.

In certain embodiments, the optimal pharmaceutical composition will be determined by one skilled in the art depending upon, for example, the intended route of administration, delivery format and desired dosage. See, for example, REMINGTON'S PHARMACEUTICAL SCIENCES, supra. In certain embodiments, such compositions may influence the physical state, stability, rate of in vivo release and rate of in vivo clearance of the antigen binding proteins disclosed. In certain embodiments, the primary vehicle or carrier in a pharmaceutical composition may be either aqueous or non-aqueous in nature. For example, a suitable vehicle or carrier may be water for injection or physiological saline solution. In certain embodiments, GIPR antigen binding protein compositions may be prepared for storage by mixing the selected composition having the desired degree of purity with optional formulation agents (REMINGTON'S PHARMACEUTICAL SCIENCES, supra) in the form of a lyophilized cake or an aqueous solution. Further, in certain embodiments, the GIPR antigen binding protein may be formulated as a lyophilizate using appropriate excipients such as sucrose.

The pharmaceutical compositions can be selected for parenteral delivery. Alternatively, the compositions may be selected for inhalation or for delivery through the digestive tract, such as orally. Preparation of such pharmaceutically acceptable compositions is within the skill of the art.

The formulation components are present preferably in concentrations that are acceptable to the site of administration. In certain embodiments, buffers are used to maintain the composition at physiological pH or at a slightly lower pH, typically within a pH range of from about 5 to about 8.

When parenteral administration is contemplated, the therapeutic compositions may be provided in the form of a pyrogen-free, parenterally acceptable aqueous solution comprising the desired human GIPR antigen binding protein in a pharmaceutically acceptable vehicle. A particularly suitable vehicle for parenteral injection is sterile distilled water in which the GIPR antigen binding protein is formulated as a sterile, isotonic solution, properly preserved. In certain embodiments, the preparation can involve the formulation of the desired molecule with an agent, such as injectable microspheres, bio-erodible particles, polymeric compounds (such as polylactic acid or polyglycolic acid), beads or liposomes, that may provide controlled or sustained release of the product which can be delivered via depot injection. In certain embodiments, hyaluronic acid may also be used, having the effect of promoting sustained duration in the circulation. In certain embodiments, implantable drug delivery devices may be used to introduce the desired antigen binding protein.

Certain pharmaceutical compositions are formulated for inhalation. In some embodiments, GIPR antigen binding proteins are formulated as a dry, inhalable powder. In specific embodiments, GIPR antigen binding protein inhalation solutions may also be formulated with a propellant for aerosol delivery. In certain embodiments, solutions may be nebulized. Pulmonary administration and formulation methods therefore are further described in International Patent Application No. PCT/US94/001875, which is incorporated by reference and describes pulmonary delivery of chemically modified proteins. Some formulations can be administered orally. GIPR antigen binding proteins that are administered in this fashion can be formulated with or without carriers customarily used in the compounding of solid dosage forms such as tablets and capsules. In certain embodiments, a capsule may be designed to release the active portion of the formulation at the point in the gastrointestinal tract when bioavailability is maximized and pre-systemic degradation is minimized. Additional agents can be included to facilitate absorption of the GIPR antigen binding protein. Diluents, flavorings, low melting point waxes, vegetable oils, lubricants, suspending agents, tablet disintegrating agents, and binders may also be employed.

Some pharmaceutical compositions comprise an effective quantity of one or a plurality of GIPR antigen binding proteins in a mixture with non-toxic excipients that are suitable for the manufacture of tablets. By dissolving the tablets in sterile water, or another appropriate vehicle, solutions may be prepared in unit-dose form. Suitable excipients include, but are not limited to, inert diluents, such as calcium carbonate, sodium carbonate or bicarbonate, lactose, or calcium phosphate; or binding agents, such as starch, gelatin, or acacia; or lubricating agents such as magnesium stearate, stearic acid, or talc.

Additional pharmaceutical compositions will be evident to those skilled in the art, including formulations involving GIPR binding proteins in sustained- or controlled-delivery formulations. Techniques for formulating a variety of other sustained- or controlled-delivery means, such as liposome carriers, bio-erodible microparticles or porous beads and depot injections, are also known to those skilled in the art. See, for example, International Patent Application No. PCT/US93/00829, which is incorporated by reference and describes controlled release of porous polymeric microparticles for delivery of pharmaceutical compositions. Sustained-release preparations may include semipermeable polymer matrices in the form of shaped articles, e.g., films, or microcapsules. Sustained release matrices may include polyesters, hydrogels, polylactides (as disclosed in U.S. Pat. No. 3,773,919 and European Patent Application Publication No. EP 058481, each of which is incorporated by reference), copolymers of L-glutamic acid and gamma ethyl-L-glutamate (Sidman et al., 1983, Biopolymers 2:547-556), poly (2-hydroxyethyl-methacrylate) (Langer et al., 1981, J. Biomed. Mater. Res. 15:167-277 and Langer, 1982, Chem. Tech. 12:98-105), ethylene vinyl acetate (Langer et al., 1981, supra) or poly-D(−)-3-hydroxybutyric acid (European Patent Application Publication No. EP 133,988). Sustained release compositions may also include liposomes that can be prepared by any of several methods known in the art. See, e.g., Eppstein et al., 1985, Proc. Natl. Acad. Sci. U.S.A. 82:3688-3692; European Patent Application Publication Nos. EP 036,676; EP 088,046 and EP 143,949, incorporated by reference.

Pharmaceutical compositions used for in vivo administration are typically provided as sterile preparations. Sterilization can be accomplished by filtration through sterile filtration membranes. When the composition is lyophilized, sterilization using this method may be conducted either prior to or following lyophilization and reconstitution. Compositions for parenteral administration can be stored in lyophilized form or in a solution. Parenteral compositions generally are placed into a container having a sterile access port, for example, an intravenous solution bag or vial having a stopper pierceable by a hypodermic injection needle.

In certain formulations, an antigen binding protein has a concentration of at least 10 mg/mL, 20 mg/mL, 30 mg/mL, 40 mg/mL, 50 mg/mL, 60 mg/mL, 70 mg/mL, 80 mg/mL, 90 mg/mL, 100 mg/mL or 150 mg/mL. In one embodiment, a pharmaceutical composition comprises the antigen binding protein, a buffer and polysorbate. In other embodiments, the pharmaceutical composition comprises an antigen binding protein, a buffer, sucrose and polysorbate. An example of a pharmaceutical composition is one containing 50-100 mg/mL of antigen binding protein, 5-20 mM sodium acetate, 5-10% w/v sucrose, and 0.002-0.008% w/v polysorbate. Certain, compositions, for instance, contain 65-75 mg/mL of an antigen binding protein in 9-11 mM sodium acetate buffer, 8-10% w/v sucrose, and 0.005-0.006% w/v polysorbate. The pH of certain such formulations is in the range of 4.5-6. Other formulations have a pH of 5.0-5.5 (e.g., pH of 5.0, 5.2 or 5.4).

Once the pharmaceutical composition has been formulated, it may be stored in sterile vials as a solution, suspension, gel, emulsion, solid, crystal, or as a dehydrated or lyophilized powder. Such formulations may be stored either in a ready-to-use form or in a form (e.g., lyophilized) that is reconstituted prior to administration. Kits for producing a single-dose administration unit are also provided. Certain kits contain a first container having a dried protein and a second container having an aqueous formulation. In certain embodiments, kits containing single and multi-chambered pre-filled syringes (e.g., liquid syringes and lyosyringes) are provided. The therapeutically effective amount of a GIPR antigen binding protein-containing pharmaceutical composition to be employed will depend, for example, upon the therapeutic context and objectives. One skilled in the art will appreciate that the appropriate dosage levels for treatment will vary depending, in part, upon the molecule delivered, the indication for which the GIPR antigen binding protein is being used, the route of administration, and the size (body weight, body surface or organ size) and/or condition (the age and general health) of the patient. In certain embodiments, the clinician may titer the dosage and modify the route of administration to obtain the optimal therapeutic effect.

Dosing frequency will depend upon the pharmacokinetic parameters of the particular GIPR antigen binding protein in the formulation used. Typically, a clinician administers the composition until a dosage is reached that achieves the desired effect. The composition may therefore be administered as a single dose, or as two or more doses (which may or may not contain the same amount of the desired molecule) over time, or as a continuous infusion via an implantation device or catheter. Appropriate dosages may be ascertained through use of appropriate dose-response data. In certain embodiments, the antigen binding proteins can be administered to patients throughout an extended time period. In certain embodiments, the antigen binding protein is dosed every two weeks, every month, every two months, every three months, every four months, every five months, or every six months.

The route of administration of the pharmaceutical composition is in accord with known methods, e.g., orally, through injection by intravenous, intraperitoneal, intracerebral (intra-parenchymal), intracerebroventricular, intramuscular, intra-ocular, intraarterial, intraportal, or intralesional routes; by sustained release systems or by implantation devices. In certain embodiments, the compositions may be administered by bolus injection or continuously by infusion, or by implantation device.

The composition also may be administered locally via implantation of a membrane, sponge or another appropriate material onto which the desired molecule has been absorbed or encapsulated. In certain embodiments, where an implantation device is used, the device may be implanted into any suitable tissue or organ, and delivery of the desired molecule may be via diffusion, timed-release bolus, or continuous administration.

It also may be desirable to use GIPR antigen binding protein pharmaceutical compositions according to the disclosed ex vivo. In such instances, cells, tissues or organs that have been removed from the patient are exposed to GIPR antigen binding protein pharmaceutical compositions after which the cells, tissues and/or organs are subsequently implanted back into the patient.

A physician will be able to select an appropriate treatment indication and target lipid levels depending on the individual profile of a particular patient. One well-accepted standard for guiding treatment of hyperlipidemia is the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of the High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report, National Institutes of Health, NIH Publication No. 02-5215 (2002), the printed publication of which is hereby incorporated by reference in its entirety.

The efficacy of a particular dose can be assessed by reference to biomarkers or improvement in certain physiological parameters. Examples of suitable biomarkers include, the ratio of free cholesterol to plasma lipid, free cholesterol to membrane protein, phospatidylcholine to sphingomyelin, or HDL-C levels.

Also provided herein are compositions comprising a GIPR antigen binding protein and one or more additional therapeutic agents, as well as methods in which such agents are administered concurrently or sequentially with a GIPR antigen binding protein for use in the preventive and therapeutic methods disclosed herein. The one or more additional agents can be co-formulated with a GIPR antigen binding protein or can be co-administered with a GIPR antigen binding protein. In general, the therapeutic methods, compositions and compounds may also be employed in combination with other therapeutics in the treatment of various disease states, with the additional agents being administered concurrently.

In one aspect the present invention is directed to a method of treating a subject with a metabolic disorder, the method comprising administering to the subject a composition comprising a GIPR antagonist that inhibits GIPR function and a GLP-1 receptor agonist, wherein the GLP-1 receptor agonist is conjugated to the GIPR antagonist. In one embodiment the GIPR antagonist inhibits GIP binding to GIPR.

In one aspect the present invention is directed to a method of treating a subject with a metabolic disorder, the method comprising administering to the subject a composition comprising an antibody or functional fragment thereof that specifically binds to human GIPR, wherein the antibody or functional fragment thereof comprises a cysteine or non-canonical amino acid amino acid substitution at one or more conjugation site(s); and a GLP-1 receptor agonist, wherein the GLP-1 receptor agonist is conjugated to the antibody or functional fragment thereof through the side-chain of the cysteine residue or non-canonical amino acid residue substituted at the one or more conjugation site(s).

In one aspect the present invention is directed to a method of treating a subject with a metabolic disorder, the method comprising administering to the subject a therapeutically effective amount of a GLP-1 receptor agonist and a therapeutically effective amount of a GIPR antagonist that specifically binds to a protein having an amino acid sequence having at least 90% amino acid sequence identity to an amino acid sequence of a GIPR, wherein the GIPR antagonist is conjugated to the GLP-1 receptor agonist. Such conjugated molecules can be referred to as “anti-GIPR/GLP-1R bispecific conjugate”, “anti-GIPR/GLP-1R peptide conjugate”, “anti-GIPR/GLP-1R conjugate”, or even “bispecific conjugate”.

In one aspect the present invention is directed to a method of promoting GIPR and GLP-1R internalization into the cell upon which they are co-expressed by administering a GIPR antagonist conjugated to a GLP-1 receptor agonist to the cell. In one embodiment, the GIPR and GLP-1R are co-localized while being internalized.

In one aspect the present invention is directed to a method of stimulating calcium flux in a cell by administering a GIPR antagonist conjugated to a GLP-1 receptor agonist to the cell.

In one aspect the present invention is directed to a method of promoting beta-arrestin recruitment in a cell by administering a GIPR antagonist conjugated to a GLP-1 receptor agonist to the cell.

In one aspect the present invention is directed to a method of stimulating insulin secretion from a cell by administering a GIPR antagonist conjugated to a GLP-1 receptor agonist to the cell. In one embodiment the cell is a human pancreatic microislet.

A “GLP-1 receptor agonist” refers to compounds having GLP-1 receptor activity. Such exemplary compounds include exendins, exendin analogs, exendin agonists, GLP-1(7-37), GLP-1(7-37) analogs, GLP-1(7-37) agonists, and the like. The GLP-1 receptor agonist compounds may optionally be amidated. The terms “GLP-1 receptor agonist” and “GLP-1 receptor agonist compound” have the same meaning.

The term “exendin” includes naturally occurring (or synthetic versions of naturally occurring) exendin peptides that are found in the salivary secretions of the Gila monster. Exendins of particular interest include exendin-3 and exendin-4. The exendins, exendin analogs, and exendin agonists for use in the methods described herein may optionally be amidated, and may also be in an acid form, pharmaceutically acceptable salt form, or any other physiologically active form of the molecule.

In one embodiment, the GLP-1 receptor agonist is GLP-1(7-37) or a GLP-1(7-37) analog.

In one embodiment, the GLP-1 receptor agonist is selected from the group consisting of exenatide, liraglutide, lixisenatide, albiglutide, dulaglutide, semaglutide, and taspoglutide.

In one aspect the present invention is directed to a method of treatment comprising administering to a subject a therapeutically effective amount of at least one GLP-1 receptor agonist in combination with administration of at least one GIPR antagonist, wherein the GIPR antagonist is conjugated to the GLP-1 receptor agonist, which upon administration to a subject with symptoms of a metabolic disorder provides sustained beneficial effects.

In one embodiment, administration of at least one GLP-1 receptor agonist in combination with administration of at least one GIPR antagonist provides sustained beneficial effects of at least one symptom of a metabolic disorder.

In one embodiment, the therapeutically effective amounts of the GLP-1 receptor agonist and the GIPR antagonist are combined prior to administration to the subject.

In one embodiment, the therapeutically effective amounts of the GLP-1 receptor agonist and the GIPR antagonist are administered to the subject sequentially.

In one embodiment, the therapeutically effective amounts of a GLP-1 receptor agonist and a GIPR antagonist are synergistically effective amounts.

Exendin-4 (HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH₂ (SEQ ID NO: 3163)) is a peptide found in the saliva of the Gila monster, Heloderma suspectum; and exendin-3 (HSDGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH₂ (SEQ ID NO: 3164)) is a peptide found in the saliva of the beaded lizard, Heloderma horridum. Exendins have some amino acid sequence similarity to some members of the glucagon-like peptide (GLP) family. For example, exendin-4 has about 53% sequence identity with glucagon-like peptide-1(GLP-1)(7-37) (HAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG (SEQ ID NO: 3184)). However, exendin-4 is transcribed from a distinct gene, not the Gila monster homolog of the mammalian proglucagon gene from which GLP-1 is expressed. Additionally, exendin-4 is not an analog of GLP-1(7-37) because the structure of synthetic exendin-4 peptide was not created by sequential modification of the structure of GLP-1. Nielsen et al., Current Opinion in Investigational Drugs, 4(4):401-405 (2003).

Synthetic exendin-4, also known as exenatide, is commercially available as BYETTA® (Amylin Pharmaceuticals, Inc. and Eli Lilly and Company). A once weekly formulation of exenatide is described in WO 2005/102293, the disclosure of which is incorporated by reference herein.

“Exendin analog” refers to peptides which elicit a biological activity of an exendin reference peptide, preferably having a potency equal to or better than the exendin reference peptide (e.g., exendin-4), or within five orders of magnitude (plus or minus) of potency compared to the exendin reference peptide, when evaluated by art-known measures such as receptor binding and/or competition studies as described, e.g., by Hargrove et al., Regulatory Peptides, 141:113-119 (2007), the disclosure of which is incorporated by reference herein. Preferably, the exendin analogs will bind in such assays with an affinity of less than 1 μM, and more preferably with an affinity of less than 3 nM, less than 1 nM, or less than 0.1 nM. The term “exendin analog” may also be referred to as “exendin agonist”. In a preferred embodiment, the exendin analog is an exendin-4 analog.

Exendin analogs also include the peptides described herein which have been chemically derivatized or altered, for example, peptides with non-natural amino acid residues (e.g., taurine, β-amino acid residues, γ-amino acid residues, and D-amino acid residues), C-terminal functional group modifications, such as amides, esters, and C-terminal ketone modifications and N-terminal functional group modifications, such as acylated amines, Schiff bases, or cyclization, as found, for example, in the amino acid pyroglutamic acid. Exendin analogs may also contain other chemical moieties, such as peptide mimetics.

Exemplary exendins and exendin analogs exendin-4 (SEQ ID NO: 3163): exendin-3 (SEQ ID NO: 3164); Leu¹⁴-exendin-4 (SEQ ID NO: 3165); Leu¹⁴,Phe²⁵-exendin-4 (SEQ ID NO: 3166); Leu¹⁴,Ala¹⁹,Phe²⁵-exendin-4 (SEQ ID NO: 3167); exendin-4 (1-30) (SEQ ID NO: 3168); Leu¹⁴-exendin-4 (1-30) (SEQ ID NO: 3169); Leu¹⁴,Phe²⁵-exendin-4 (1-30) (SEQ ID NO: 3170); Leu¹⁴,Ala¹⁹,Phe²⁵-exendin-4 (1-30) (SEQ ID NO: 3171): exendin-4 (1-28) (SEQ ID NO: 3172); Leu¹⁴-exendin-4 (1-28) (SEQ ID NO: 3173); Leu¹⁴,Phe²⁵-exendin-4 (1-28) (SEQ ID NO: 3174); Leu¹⁴,Ala¹⁹,Phe²⁵-exendin-4 (1-28) (SEQ NO: 3175); Leu¹⁴,Lys^(17,20),Ala¹⁹,Glu²¹,Phe²⁵,Gln²⁸-exendin-4 (SEQ ID NO: 3176): Leu¹⁴,Lys^(17,20),Ala¹⁹,Glu²¹,Gln²⁸-exendin-4 (SEQ ID NO: 3177); octylGly¹⁴,Gln²⁸-exendin-4 (SEQ ID NO: 3178); Leu¹⁴,Gln²⁸,octylGly³⁴-exendin-4 (SEQ ID NO: 3179); Phe⁴,Leu¹⁴,Gln²⁸,Lys³³,Glu³⁴,Ile^(35,36),Ser³⁷-exendin-4 (1-37) (SEQ ID NO: 3180), Phe⁴,Leu¹⁴,Lys^(17,20),Ala¹⁹,Glu²¹,Gln²⁸-exendin-4 (SEQ ID NO: 3181); Val¹¹,Ile¹³,Leu¹⁴,Ala¹⁶,Lys²¹,Phe²⁵-exendin-4 (SEQ ID NO: 3182); exendin-4-Lys⁴⁰ (SEQ ID NO: 3183); lixisenatide (Sanofi-Aventis/Zealand Pharma); CJC-1134 (ConjuChem, Inc.); [N^(e)-(17-carboxyheptadecanoic acid)Lys²⁰]exendin-4-NH₂ (SEQ ID NO: 3208); [N^(e)-(17-carboxyhepta-decanoyl)Lys³²]exendin-4-NH₂ (SEQ ID NO: 3209); [desamino-His¹,N^(e)-(17-carboxyheptadecanoyl)Lys²⁰]exendin-4-NH₂ (SEQ ID NO: 3210); [Arg^(12,27),NLe¹⁴,N^(e)-(17-carboxy-heptadecanoyl)Lys³²]exendin-4-NH₂ (SEQ ID NO: 3211); [N^(e)-(19-carboxy-nonadecanoylamino)Lys²⁰]-exendin-4-NH₂ (SEQ ID NO: 3212); [N^(e)-(15-carboxypentadecanoylamino)Lys²⁰]-exendin-4-NH₂ (SEQ ID NO: 3213); [N^(e)-(13-carboxytridecanoylamino)Lys²⁰]exendin-4-NH₂ (SEQ ID NO: 3214); [N^(e)-(11-carboxy-undecanoyl-amino)Lys²⁰]exendin-4-NH₂ (SEQ ID NO: 3215); exendin-4-Lys⁴⁰(e-MPA-NH₂ (SEQ ID NO: 3216); exendin-4-Lys⁴⁰(e-AEEA-AEEA-MPA)-NH₂ (SEQ ID NO: 3217); exendin-4-Lys⁴⁰(e-AEEA-MPA)-NH₂ (SEQ ID NO: 3218); exendin-4-Lys⁴⁰(e-MPA)-albumin (SEQ ID NO: 3219); exendin-4-Lys⁴⁰(e-AEEA-AEEA-MPA)-albumin (SEQ ID NO: 3220); exendin-4-Lys⁴⁰(e-AEEA-MPA)-albumin (SEQ ID NO: 3221); and the like. AEEA refers to [2-(2-amino)ethoxy)]acetic acid. EDA refers to ethylenediamine, MPA refers to maleimidopropionic acid. The exendins and exendin analogs may optionally be amidated.

In one embodiment, the GLP-1 receptor agonist compound is an exendin-4 analog that has at least 80% sequence identity to exendin-4 (SEQ ID NO: 3163); at least 85% sequence identity to exendin-4 (SEQ ID NO: 3163); at least 90% sequence identity to exendin-4 (SEQ ID NO: 3163); or at least 95% sequence identity to exendin-4 (SEQ ID NO: 3163).

Other exendins and exendin analogs useful in the methods described herein include those described in WO 98/05351; WO 99/07404; WO 99/25727; WO 99/25728; WO 99/40788; WO 00/41546; WO 00/41548; WO 00/73331; WO 01/51078; WO 03/099314; U.S. Pat. Nos. 6,956,026; 6,506,724; 6,703,359; 6,858,576; 6,872,700; 6,902,744; 7,157,555; 7,223,725; 7,220,721; US Publication No. 2003/0036504; and US Publication No. 2006/0094652, the disclosures of which are incorporated by reference herein in their entirety.

“GLP-1(7-37) analogs” refers to peptides which elicit a biological activity similar to that of GLP-1(7-37), when evaluated by art-known measures such as receptor binding assays or in vivo blood glucose assays as described, e.g., by Hargrove et al., Regulatory Peptides, 141:113-119 (2007), the disclosure of which is incorporated by reference herein. In one embodiment, the term “GLP-1(7-37) analog” refers to a peptide that has an amino acid sequence with 1, 2, 3, 4, 5, 6, 7 or 8 amino acid substitutions, insertions, deletions, or a combination of two or more thereof, when compared to the amino acid sequence of GLP-1(7-37). In one embodiment, the GLP-1(7-37) analog is GLP-1(7-36)-NH₂. GLP-1(7-37) analogs include the amidated forms, the acid form, the pharmaceutically acceptable salt form, and any other physiologically active form of the molecule. In some embodiments a simple nomenclature is used to describe the GLP-1 receptor agonist, e.g., [Aib8]GLP-1(7-37) designates an analogue of GLP-1(7-37) wherein the naturally occurring Ala in position 8 has been substituted with Aib.

Exemplary GLP-1(7-37) and GLP-1(7-37) analogs include GLP-1(7-37) (SEQ ID NO: 3184); GLP-1(7-36)-NH₂ (SEQ ID NO: 3185); liragiutide (VICTOZA® from Novo Nordisk); albiglutide (SYNCRIA® from GlaxoSmithKline); taspoglutide (Hoffman La-Roche); dulaglutide (also known LY2189265; Eli Lilly and Company); LY2428757 (Eli Lilly and Company); desamino-His⁷,Arg²⁶,Lys³⁴(N^(ε)-(γ-Glu(N-α-hexadecanoyl)))-GLP-1(7-37) (core peptide disclosed as SEQ ID NO: 3222); desamino-His⁷,Arg²⁶,Lys³⁴(N^(ε)-octanoyl)-GLP-1(7-37) (SEQ ID NO: 3223); Arg^(26,34),Lys³⁸(N^(ε)-(ω-carboxypentadecanoyl))-GLP-1(7-38) (SEQ ID NO: 3224); Arg^(26,34),Lys³⁶(N^(ε)-(γ-Glu(N-α-hexadecanoyl)))-GLP-1(7-36) (core peptide disclosed as SEQ ID NO: 3225); Aib^(8,35),Arg^(26,34),Phe³¹-GLP-1(7-36)) (SEQ ID NO: 3186); HXaa₈EGTFTSDVSSYLEXaa₂₂Xaa₂₃AAKEFIXaa₃₀WLXaa₃₃Xaa₃₄G Xaa₃₆Xaa₃₇; wherein Xaa₃ is A, V, or G; Xaa₂₂ is G, K, or E; Xaa₂₃ is Q or K; Xaa₃₀ is A or E; Xaa₃₃ is V or K: Xaa₃₄ is K, N, or R; Xaa₃₆ is R or G; and Xaa₃₇ is G, H, P, or absent (SEQ ID NO: 3187); Arg³⁴-GLP-1(7-37) (SEQ ID NO: 3188); Glu³⁰-GLP-1(7-37) (SEQ ID NO: 3189); Lys²²-GLP-1(7-37) (SEQ ID NO: 3190); Gly^(8,36),Glu²²-GLP-1(7-37) (SEQ ID NO: 3191); Val⁸,Glu²²,Gly³⁶-GLP-1(7-37) (SEQ ID NO: 3192); Gly^(8,36),Glu²²,Lys³³,Asn³¹-GLP-1(7-37) (SEQ ID NO: 3193); Val⁸,Glu²²,Lys³³,Asn³⁴,Gly³⁶-GLP-1(7-37) (SEQ ID NO: 3194); Gly^(8,36),Glu²²,Pro³⁷-GLP-1(7-37) (SEQ ID NO: 3195), Val⁸,Glu²²,Gly³⁶Pro³⁷-GLP-1(7-37) (SEQ ID NO: 3196); Gly^(8,36),Glu²²,Lys³³, Asn³⁴,Pro³⁷-GLP-1(7-37) (SEQ ID NO: 3197); Val⁸,Glu²²,Lys³³,Asn³⁴,Gly³⁶,Pro³⁷-GLP-1(7-37) (SEQ ID NO: 3198); Gly^(8,36),Glu²²-GLP-1(7-36) (SEQ ID NO: 3199); Val⁸,Glu²²,Gly³⁶-GLP-1(7-36) (SEQ ID NO: 3200); Val⁸,Glu²²,Asn³⁴,Gly³⁶-GLP-1(7-36) (SEQ ID NO: 3201); Gly^(8,36),Glu²²,Asn³⁴-GLP-1(7-36) (SEQ ID NO: 3202). Each of the GLP-1(7-37) and GLP-1(7-37) analogs may optionally be amidated.

The GLP-1 receptor agonists of the inventive composition of matter can also be chemically derivatized at one or more amino acid residues by known organic chemistry techniques. “Chemical derivative” or “chemically derivatized” refers to a subject peptide having one or more residues chemically derivatized by reaction of a functional side group. Such derivatized molecules include, for example, those molecules in which free amino groups have been derivatized to form amine hydrochlorides, p-toluene sulfonyl groups, carbobenzoxy groups, t-butyloxycarbonyl groups, chloroacetyl groups or formyl groups. Free carboxyl groups may be derivatized to form salts, methyl and ethyl esters or other types of esters or hydrazides. Free hydroxyl groups may be derivatized to form O-acyl or O-alkyl derivatives. The imidazole nitrogen of histidine may be derivatized to form N-im-benzylhistidine. Also included as chemical derivatives are those peptides which contain one or more naturally occurring amino acid derivatives of the twenty canonical amino acids, whether in L- or D-form. For example, 4-hydroxyproline may be substituted for proline; 5-hydroxylysine maybe substituted for lysine; 3-methylhistidine may be substituted for histidine; homoserine may be substituted for serine; and ornithine may be substituted for lysine.

Useful derivatizations include, in some embodiments, those in which the amino terminal of the peptide is chemically blocked so that conjugation with the vehicle will be prevented from taking place at an N-terminal free amino group. There may also be other beneficial effects of such a modification, for example a reduction in the toxin peptide analog's susceptibility to enzymatic proteolysis. The N-terminus can be acylated or modified to a substituted amine, or derivatized with another functional group, such as an aromatic moiety (e.g., an indole acid, benzyl (Bzl or Bn), dibenzyl (DiBzl or Bn₂), or benzyloxycarbonyl (Cbz or Z)), N,N-dimethylglycine or creatine. For example, in some embodiments, an acyl moiety, such as, but not limited to, a formyl, acetyl (Ac), propanoyl, butanyl, heptanyl, hexanoyl, octanoyl, or nonanoyl, can be covalently linked to the N-terminal end of the peptide, which can prevent undesired side reactions during conjugation of the vehicle to the peptide. Other exemplary N-terminal derivative groups include —NRR¹ (other than —NH₂), —NRC(O)R¹, —NRC(O)OR¹, —NRS(O)₂R¹, —NHC(O)NH¹, succinimide, or benzyloxycarbonyl-NH— (Cbz-NH—), wherein R and R¹ are each independently hydrogen or lower alkyl and wherein the phenyl ring may be substituted with 1 to 3 substituents selected from C₁-C₄ alkyl, C₁-C₄ alkoxy, chloro, and bromo.

In some embodiments, one or more peptidyl [—C(O)NR—] linkages (bonds) between amino acid residues can be replaced by a non-peptidyl linkage. Exemplary non-peptidyl linkages are —CH₂-carbamate [—CH₂—OC(O)NR—], phosphonate, —CH₂-sulfonamide [—CH₂—S(O)₂NR—], urea [—NHC(O)NH—], —CH₂-secondary amine, and alkylated peptide [—C(O)NR⁶— wherein R⁶ is lower alkyl].

In some embodiments, one or more individual amino acid residues can be derivatized. Various derivatizing agents are known to react specifically with selected sidechains or terminal residues, as described in detail below by way of example.

Lysinyl residues and amino terminal residues may be reacted with succinic or other carboxylic acid anhydrides, which reverse the charge of the lysinyl residues. Other suitable reagents for derivatizing alpha-amino-containing residues include imidoesters such as methyl picolinimidate; pyridoxal phosphate; pyridoxal; chloroborohydride; trinitrobenzenesulfonic acid; O-methylisourea; 2,4 pentanedione; and transaminase-catalyzed reaction with glyoxylate.

Arginyl residues may be modified by reaction with any one or combination of several conventional reagents, including phenylglyoxal, 2,3-butanedione, 1,2-cyclohexanedione, and ninhydrin. Derivatization of arginyl residues requires that the reaction be performed in alkaline conditions because of the high pKa of the guanidine functional group. Furthermore, these reagents may react with the groups of lysine as well as the arginine epsilon-amino group.

Specific modification of tyrosyl residues has been studied extensively, with particular interest in introducing spectral labels into tyrosyl residues by reaction with aromatic diazonium compounds or tetranitromethane. Most commonly, N-acetylimidizole and tetranitromethane are used to form O-acetyl tyrosyl species and 3-nitro derivatives, respectively.

Carboxyl sidechain groups (aspartyl or glutamyl) may be selectively modified by reaction with carbodiimides (R′—N═C═N—R′) such as 1-cyclohexyl-3-(2-morpholinyl-(4-ethyl) carbodiimide or 1-ethyl-3-(4-azonia-4,4-dimethylpentyl) carbodiimide. Furthermore, aspartyl and glutamyl residues may be converted to asparaginyl and glutaminyl residues by reaction with ammonium ions.

Glutaminyl and asparaginyl residues may be deamidated to the corresponding glutamyl and aspartyl residues. Alternatively, these residues are deamidated under mildly acidic conditions. Either form of these residues falls within the scope of this invention.

Cysteinyl residues can be replaced by amino acid residues or other moieties either to eliminate disulfide bonding or, conversely, to stabilize cross-linking. (See, e.g., Bhatnagar et al., J. Med. Chem., 39:3814-3819 (1996)).

Other possible modifications include hydroxylation of proline and lysine, phosphorylation of hydroxyl groups of seryl or threonyl residues, oxidation of the sulfur atom in Cys, methylation of the alpha-amino groups of lysine, arginine, and histidine side chains. Creighton, Proteins: Structure and Molecule Properties (W. H. Freeman & Co., San Francisco), 79-86 (1983).

The above examples of derivatizations are not intended to be an exhaustive treatment, but merely illustrative

In one embodiment, the GLP-1(7-37) or GLP-1(7-37) analogs are covalently linked (directly or by a linking group) to an Fc portion of an immunoglobulin (e.g., IgG, IgE, and the like). For example, any one of SEQ ID NOs:25-40 may be covalently linked to the Fc portion of an immunoglobulin comprising the sequence of: AESKYGPPCPPCPAPXaa₁₆Xaa₁₇Xaa₁₈GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQ EDPEVQFNWYVDGVEVHNAKTKPREEQFXaa₈₀STYRVVSVLTVLHQDWLNGKEYK CKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIA VEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHN HYTQKSLSLSLGXaa₂₃₀; wherein Xaa₁₆ is P or E; Xaa₁₇; is F, V or A; Xaa₁₈ is L, E or A; Xaa₈₀ is N or A; and Xaa₂₃₀ is K or absent (SEQ ID NO: 3203). The linking group may be any chemical moiety (e.g., amino acids and/or chemical groups). In one embodiment, the linking group is (-GGGGS-)_(x) (SEQ ID NO: 3204) where x is 1, 2, 3, 4, 5 or 6; preferably 2, 3 or 4; more preferably 3. In one embodiment, the GLP-1(7-37) analog covalently linked to the Fc portion of an immunoglobulin comprises the amino acid sequence:

(SEQ ID NO: 3205) HGEGTFTSDVSSYLEEQAAKEFIAWLVKGGGGGGGSGGGGSGGGGSAESK YGPPCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDP EVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKC KVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGN VFSCSVMHEALHNHYTQKSLSLSLG.

In another embodiment, the GLP-1(7-37) or GLP-1(7-37) analog may be covalently linked (directly or through a linking group) to one or two polyethylene glycol molecules. For example, a GLP-1(7-37) analog may comprise the amino acid sequence: HXaa₈EGTFTSDVS SYLEXaa₂₂QAAKEFIAWLXaa₃₃KGGPSSGAPPPC₄₅C₄₆-Z, wherein Xaa₈ is: D-Ala, G, V, L, I, S or T; Xaa₂₂ is G, E, D or K; Xaa₃₃ is: V or I; and Z is OH or NH₂, (SEQ ID NO: 3206), and, optionally, wherein (i) one polyethylene glycol moiety is covalently attached to C₄₅, (ii) one polyethylene glycol moiety is covalently attached to C₄₆, or (iii) one polyethylene glycol moiety is attached to C₄₅ and one polyethylene glycol moiety is attached to C₄₆. In one embodiment, the GLP-1(7-37) analog is HVEGTFTSDVSSYLEEQAAKEFI AWLIKGGPSSGAPPPC₄₅C₄₆—NH₂ (SEQ ID NO: 3207) and, optionally, wherein (i) one polyethylene glycol moiety is covalently attached to C₄, (ii) one polyethylene glycol moiety is covalently attached to C₄₆, or (iii) one polyethylene glycol moiety is attached to C₄₅ and one polyethylene glycol moiety is attached to C₄₆.

GLP-1 receptor agonist amino acid residues that can provide a primary amine moiety for conjugation include residues of lysine, homolysine, ornithine, α, β-diaminopropionic acid (Dap), α, β-diaminopropionoic acid (Dpr), and α, γ-diaminobutyric acid (Dab), aminobutyric acid (Abu), and α-amino-isobutyric acid (Aib). The polypeptide N-terminus also provides a useful α-amino group for conjugation as does an amidated polypeptide C-terminus. In certain embodiments, the GLP-1(7-37) or GLP-1(7-37) analog is conjugated to the antibody or fragment thereof at a residue that corresponds to K26 (position 20 of SEQ ID NO: 3184), K34 (position 28 of SEQ ID NO: 3184), K36 (position 30 of SEQ ID NO: 3184; e.g., via a R36K mutation), K37 (position 31 of SEQ ID NO: 3184; e.g., via a G37K mutation), K39 (e.g., via addition of two amino acids to the GLP-1(7-37) or GLP-1(7-37) analog with lysine at position 39) or a C-terminal amine group of said analog. Amino acid residues that can provide a secondary amine moiety include ε-N-alkyl lysine, α-N-alkyl lysine, δ-N-alkyl ornithine, α-N-alkyl ornithine, or an N-terminal proline, where the alkyl is C₁ to C₆.

A “linker moiety” as used herein refers to a biologically acceptable peptidyl or non-peptidyl organic group that is covalently bound to an amino acid residue of a toxin peptide analog or other polypeptide chain (e.g., an immunoglobulin HC or LC or immunoglobulin Fc domain) contained in the inventive composition, which linker moiety covalently joins or conjugates the toxin peptide analog or other polypeptide chain to another peptide or polypeptide chain in the composition, or to a half-life extending moiety. In some embodiments of the composition, a half-life extending moiety, as described herein, is conjugated, i.e., covalently bound directly to an amino acid residue of the toxin peptide analog itself, or optionally, to a peptidyl or non-peptidyl linker moiety (including but not limited to aromatic or aryl linkers) that is covalently bound to an amino acid residue of the toxin peptide analog. The presence of any linker moiety is optional. When present, its chemical structure is not critical, since it serves primarily as a spacer to position, join, connect, or optimize presentation or position of one functional moiety in relation to one or more other functional moieties of a molecule of the inventive composition. The presence of a linker moiety can be useful in optimizing pharmacological activity of some embodiments of the inventive composition. The linker, if present, can be made up of amino acids linked together by peptide bonds. The linker moiety, if present, can be independently the same or different from any other linker, or linkers, that may be present in the inventive composition. In some embodiments the linker can be a multivalent linker that facilitates multivalent display of toxin peptide analogs of the present invention; multivalent display of such biologically active compounds can increase binding affinity and/or potency through avidity. The in vivo properties of a therapeutic can be altered (i.e., specific targeting, half-life extension, distribution profile, etc.) through conjugation to a polymer or protein.

Peptidyl linkers. As stated above, the linker moiety, if present (whether within the primary amino acid sequence of the toxin peptide analog, or as a linker for attaching a half-life extending moiety to the toxin peptide analog), can be “peptidyl” in nature (i.e., made up of amino acids linked together by peptide bonds) and made up in length, preferably, of from 1 up to about 40 amino acid residues, more preferably, of from 1 up to about 20 amino acid residues, and most preferably of from 1 to about 10 amino acid residues. Preferably, but not necessarily, the amino acid residues in the linker are from among the twenty canonical amino acids, more preferably, cysteine, glycine, alanine, proline, asparagine, glutamine, and/or serine. Even more preferably, a peptidyl linker is made up of a majority of amino acids that are sterically unhindered, such as glycine, serine, and alanine linked by a peptide bond. It is also desirable that, if present, a peptidyl linker be selected that avoids rapid proteolytic turnover in circulation in vivo. Some of these amino acids may be glycosylated, as is well understood by those in the art. For example, a useful linker sequence constituting a sialylation site is X₁X₂NX₄X₅G (SEQ ID NO: 3250), wherein X₁, X₂, X₄ and X₅ are each independently any amino acid residue.

In other embodiments, the 1 to 40 amino acids of the peptidyl linker moiety are selected from glycine, alanine, proline, asparagine, glutamine, and lysine. Preferably, a linker is made up of a majority of amino acids that are sterically unhindered, such as glycine and alanine. Thus, preferred linkers include polyglycines, polyserines, and polyalanines, or combinations of any of these. Some exemplary peptidyl linkers are poly(Gly)₁₋₈, particularly (Gly)₃ (SEQ ID NO:3251), (Gly)₄ (SEQ ID NO:480), (Gly)₅ (SEQ ID NO:3251) and (Gly)₇ (SEQ ID NO:3252), as well as, GlySer and poly(Gly)₄Ser, such as “L15” (GGGGSGGGGSGGGGS; SEQ ID NO:3253), poly(Gly-Ala)₂₋₄ and poly(Ala)₁₋₈. Other specific examples of peptidyl linkers include (Gly)₅Lys (SEQ ID NO:3254), and (Gly)₅LysArg (SEQ ID NO:3255). Other examples of useful peptidyl linkers are: Other examples of useful peptidyl linkers are:

(SEQ ID NO: 3256) (Gly)₃Lys(Gly)₄; (SEQ ID NO: 3257) (Gly)₃AsnGlySer(Gly)₂; (SEQ ID NO: 3258) (Gly)₃Cys(Gly)₄; and (SEQ ID NO: 3259) GlyProAsnGlyGly.

To explain the above nomenclature, for example, (Gly)₃Lys(Gly)₄ means Gly-Gly-Gly-Lys-Gly-Gly-Gly-Gly (SEQ ID NO:3260). Other combinations of Gly and Ala are also useful.

Other preferred linkers are those identified herein as “L5” (GGGGS; or “G₄S”; SEQ ID NO:3261), “L10” (GGGGSGGGGS; SEQ ID NO:3262); “L20” (GGGGSGGGGSGGGGSGGGGS; SEQ ID NO:3263); “L25” (GGGGSGGGGSGGGGSGGGGSGGGGS; SEQ ID NO:3264) and any linkers used in the working examples hereinafter.

In some embodiments of the compositions of this invention, which comprise a peptide linker moiety, acidic residues, for example, glutamate or aspartate residues, are placed in the amino acid sequence of the linker moiety. Examples include the following peptide linker sequences:

(SEQ ID NO: 3265) GGEGGG; (SEQ ID NO: 3266) GGEEEGGG; (SEQ ID NO: 3267) GEEEG; (SEQ ID NO: 3268) GEEE; (SEQ ID NO: 3269) GGDGGG; (SEQ ID NO: 3270) GGDDDGG; (SEQ ID NO: 3271) GDDDG; (SEQ ID NO: 3272) GDDD; (SEQ ID NO: 3273) GGGGSDDSDEGSDGEDGGGGS; (SEQ ID NO: 3274) WEWEW; (SEQ ID NO: 3275) FEFEF; (SEQ ID NO: 3276) EEEWWW; (SEQ ID NO: 3277) EEEFFF; (SEQ ID NO: 3278) WWEEEWW; or (SEQ ID NO: 3279) FFEEEFF .

In other embodiments, the linker constitutes a phosphorylation site, e.g., X₁X₂YX₄X₅G (SEQ ID NO:3280), wherein X₁, X₂, X₄, and X₅ are each independently any amino acid residue; X₁X₂SX₄X₅G (SEQ ID NO:3281), wherein X₁, X₂, X₄ and X₅ are each independently any amino acid residue; or X₁X₂TX₄X₅G (SEQ ID NO:3282), wherein X₁, X₂, X₄ and X₅ are each independently any amino acid residue.

The linkers shown here are exemplary; peptidyl linkers within the scope of this invention may be much longer and may include other residues. A peptidyl linker can contain, e.g., a cysteine, another thiol, or nucleophile for conjugation with a half-life extending moiety. In another embodiment, the linker contains a cysteine or homocysteine residue, or other 2-amino-ethanethiol or 3-amino-propanethiol moiety for conjugation to maleimide, iodoacetaamide or thioester, functionalized half-life extending moiety.

Another useful peptidyl linker is a large, flexible linker comprising a random Gly/Ser/Thr sequence, for example: GSGSATGGSGSTASSGSGSATH (SEQ ID NO:3283) or HGSGSATGGSGSTASSGSGSAT (SEQ ID NO:3284), that is estimated to be about the size of a 1 kDa PEG molecule. Alternatively, a useful peptidyl linker may be comprised of amino acid sequences known in the art to form rigid helical structures (e.g., Rigid linker: -AEAAAKEAAAKEAAAKAGG-//SEQ ID NO:3285). Additionally, a peptidyl linker can also comprise a non-peptidyl segment such as a 6 carbon aliphatic molecule of the formula —CH₂—CH₂—CH₂—CH₂—CH₂—CH₂—. The peptidyl linkers can be altered to form derivatives as described herein.

Non-peptidyl linkers. Optionally, a non-peptidyl linker moiety is also useful for conjugating the half-life extending moiety to the peptide portion of the half-life extending moiety-conjugated toxin peptide analog. For example, alkyl linkers such as —NH—(CH₂)_(s)—C(O)—, wherein s=2-20 can be used. These alkyl linkers may further be substituted by any non-sterically hindering group such as lower alkyl (e.g., C₁-C₆) lower acyl, halogen (e.g., Cl, Br), CN, NH₂, phenyl, etc. Exemplary non-peptidyl linkers are PEG linkers (e.g., shown below):

wherein n is such that the linker has a molecular weight of about 100 to about 5000 Daltons (Da), preferably about 100 to about 500 Da.

In one embodiment, the non-peptidyl linker is aryl. The linkers may be altered to form derivatives in the same manner as described herein. “Aryl” is phenyl or phenyl vicinally-fused with a saturated, partially-saturated, or unsaturated 3-, 4-, or 5 membered carbon bridge, the phenyl or bridge being substituted by 0, 1, 2 or 3 substituents selected from C₁₋₈ alkyl, C₁₋₄ haloalkyl or halo. “Heteroaryl” is an unsaturated 5, 6 or 7 membered monocyclic or partially-saturated or unsaturated 6-, 7-, 8-, 9-, 10- or 11 membered bicyclic ring, wherein at least one ring is unsaturated, the monocyclic and the bicyclic rings containing 1, 2, 3 or 4 atoms selected from N, O and S, wherein the ring is substituted by 0, 1, 2 or 3 substituents selected from C₁₋₈ alkyl, C₁₋₄ haloalkyl and halo.

Non-peptide portions of the inventive composition of matter, such as non-peptidyl linkers or non-peptide half-life extending moieties can be synthesized by conventional organic chemistry reactions.

Other embodiments of the multivalent linker comprise a rigid polyheterocyclic core of controlled length. The linkers are chemically differentiated on either end to accommodate orthogonal coupling chemistries (i.e. azide “Click”, amide coupling, thioether formation by alkylation with maleimide or haloacetamide, oxime formation, reductive amination, etc.).

The above is merely illustrative and not an exhaustive treatment of the kinds of linkers that can optionally be employed in accordance with the present invention.

In one embodiment, the GLP-1 receptor agonist compound is a peptide that has at least 80% sequence identity to GLP-1(7-37) (SEQ ID NO: 3184); at least 85% sequence identity to GLP-1(7-37) (SEQ ID NO: 3184); at least 90% sequence identity to GLP-1(7-37) (SEQ ID NO: 3184); or at least 95% sequence identity to GLP-1(7-37) (SEQ ID NO: 3184).

GLP-1 receptor agonist compounds may be prepared by processes well known in the art, e.g., peptide purification as described in Eng et al., J. Biol. Chem., 265:20259-62 (1990); standard solid-phase peptide synthesis techniques as described in Raufman et al., J. Biol. Chem., 267:21432-37 (1992); recombinant DNA techniques as described in Sambrook et al., Molecular Cloning: A Laboratory Manual, 2d Ed., Cold Spring Harbor (1989); and the like.

TABLE 7 Examples of GLP-1 receptor agonist Sequences SEQ ID NO: Sequence Description 3163 HGEGTFTSDLSKQMEEEAVRLFIEWLKN Exendin-4 GGPSSGAPPPS 3164 HSDGTFTSDLSKQMEEEAVRLFIEWLKN Exendin-3 GGPSSGAPPPS 3165 HGEGTFTSDLSKQLEEEAVRLFIEWLKN Leu¹⁴-exendin-4 GGPSSGAPPPS 3166 HGEGTFTSDLSKQLEEEAVRLFIEFLKN Leu¹⁴, Phe²⁵-exendin-4 GGPSSGAPPPS 3167 HGEGTFTSDLSKQLEEEAARLFIEFLKN Leu¹⁴, Ala¹⁹, Phe²⁵-exendin-4 GGPSSGAPPPS 3168 HGEGTFTSDLSKQMEEEAVRLFIEWLKN exendin-4(1-30) GG 3169 HGEGTFTSDLSKQLEEEAVRLFIEWLKN Leu¹⁴-exendin-4(1-30) GG 3170 HGEGTFTSDLSKQLEEEAVRLFIEFLKN Leu¹⁴, Phe²⁵-exendin-4(1-30) GG 3171 HGEGTFTSDLSKQLEEEAARLFIEFLKN Leu¹⁴, Ala¹⁹, Phe²⁵-exendin-4(1-30) GG 3172 HGEGTFTSDLSKQMEEEAVRLFIEWLKN exendin-4(1-28) 3173 HGEGTFTSDLSKQLEEEAVRLFIEWLKN Leu¹⁴-exendin-4(1-28) 3174 HGEGTFTSDLSKQLEEEAVRLFIEFLKN Leu¹⁴, Phe²⁵-exendin-4(1-28) 3175 HGEGTFTSDLSKQLEEEAARLFIEFLKN Leu¹⁴, Ala¹⁹, Phe²⁵-exendin-4(1-28)  3176 HGEGTFTSDLSKQLEEKAAKEFIEFLKQ Leu¹⁴, Lys^(17,20), Ala¹⁹, Glu²¹, Phe²⁵, Gln²⁸- GGPSSGAPPPS exendin-4 3177 HGEGTFTSDLSKQLEEKAAKEFIEWLKQ Leu¹⁴,Lys^(17,20), Ala¹⁹, Glu²¹, Gln²⁸- GGPSSGAPPPS exendin-4 3178 HGEGTFTSDLSKQ(octylG)EEEAVRL octylGly¹⁴, Gln²⁸-exendin-4 FIEWLKQGGPSSGAPPPS 3179 HGEGTFTSDLSKQLEEEAVRLFIEWLKQ Leu¹⁴, Gln²⁸, octylGly³⁴-exendin-4 GGPSS(octylG)APPPS 3180 HGEFTFTSDLSKQLEEEAVRLFIEWLKQ Phe⁴, Leu¹⁴, Gln²⁸, Lys³³, Glu³⁴, GGPSKEIIS Ile^(35,36), Ser³⁷-exendin-4(1-37) 3181 HGEFTFTSDLSKQLEEKAAKEFIEWLKQ Phe⁴, Leu¹⁴, Lys^(17,20), Ala¹⁹, Glu²¹, Gln²⁸- GGPSSGAPPPS exendin-4 3182 HGEGTFTSDLVKILEAEAVRKFIEFLKN Val¹¹, Ile¹³, Leu¹⁴, Ala¹⁶, Lys²¹, Phe²⁵- GGPSSGAPPPS exendin-4 3183 HGEGTFTSDLSKQMEEEAVRLFIEWLKN exendin-4-Lys⁴⁰ GGPSSGAPPPSK 3184 HAEGTFTSDVSSYLEGQAAKEFIAWLVK GLP-1(7-37) GRG 3185 HAEGTFTSDVSSYLEGQAAKEFIAWLVK GLP-1(7-36)-NH₂ GR 3186 H(Aib)EGTFTSDVSSYLEGQAAREFIA Aib^(8,35), Arg2^(6,34), Phe³¹-GLP-1(7-36)) FLVR(Aib)R 3187 HXaa₈EGTFTSDVSSYLEXaa₂₂Xaa₂₃AA HXaa₈EGTFTSDVSSYLEXaa₂₂X KEFI aa₂₃AAKEFIXaa₃₀WLXaa₃₃Xaa₃₄ Xaa₃₀WLXaa₃₃Xaa₃₄GXaa₃₆Xaa₃₇ GXau₃₆Xaa₃₇ wherein Xaa₈ is A, V, or G wherein Xaa₈ is A, V, or G Xaa₂₂ is G, K, or E Xaa₂₂ is G, K, or E Xaa₂₃ is Q or K Xaa₂₃ is Q or K Xaa₃₀ is A or E Xaa₃₀ is A or E Xaa₃₃ is V or K Xaa₃₃ is V or K Xaa₃₄ is K, N, or R Xaa₃₄ is K, N, or R Xaa₃₆ is R or G Xaa₃₆ is R or G and Xaa₃₇ is G, H, P, or and Xaa₃₇ is G, H, P, or absent absent 3188 HAEGTFTSDVSSYLEGQAAKEFIAWLVR Arg³⁴-GLP-1(7-37) GRG 3189 HAEGTFTSDVSSYLEGQAAKEFIEWLVK Glu³⁰-GLP-1(7-37) GRG 3190 HAEGTFTSDVSSYLEKQAAKEFIAWLVK Lys²²-GLP-1(7-37) GRG 3191 HGEGTFTSDVSSYLEEQAAKEFIAWLVK Gly^(8,36), Glu²²-GLP-1(7-37) GGG 3192 HVEGTFTSDVSSYLEEQAAKEFIAWLVK Val⁸, Glu²², Gly³⁶-GLP-1(7-37) GGG 3193 HGEGTFTSDVSSYLEEQAAKEFIAWLKN Gly^(8,36), Glu²², Lys³³, Asn³⁴-GLP- GGG 1(7-37) 3194 HVEGTFTSDVSSYLEEQAAKEFIAWLKN Val₈, Glu₂₂, Lys₃₃, Asn₃₄, Gl_(y36)- GGG GLP-1(7-37) 3195 HGEGTFTSDVSSYLEEQAAKEFIAWLVK Gly^(8,36), Glu²², Pro³⁷-GLP-1(7-37) GGP 3196 HVEGTFTSDVSSYLEEQAAKEFIAWLVK Val⁸, Glu²², Gly³⁶, Pro³⁷-GLP-1(7- GGP 37) 3197 HGEGTFTSDVSSYLEEQAAKEFIAWLKN Gly^(8,36), Glu²², Lys³³, Asn³⁴, Pro³⁷- GGP GLP-1(7-37) 3198 HVEGTFTSDVSSYLEEQAAKEFIAWLKN Val⁸, Glu²², Lys³³, Asn³⁴, Gly³⁶, Pro³⁷- GGP GLP-1(7-37) 3199 HGEGTFTSDVSSYLEEQAAKEFIAWLVK Gly^(8,36), Glu²²-GLP-1(7-36) GG 3200 HVEGTFTSDVSSYLEEQAAKEFIAWLVK Val⁸, Glu²², Gly³⁶-GLP-1(7-36) GG 3201 HVEGTFTSDVSSYLEEQAAKEFIAWLVN Val⁸, Glu²², Asn³⁴, Gly³⁶-GLP-1(7- GG 36) 3202 HGEGTFTSDVSSYLEEQAAKEFIAWLVN Gly^(8,36), Glu²², Asn³⁴-GLP-1(7-36) GG 3203 AESKYGPPCPPCPAPXaa₁₆Xaa₁₇Xaa₁₈ Fc portion of an immunoglobulin GGPSVFLFPPKPKDTLMISRTPEVTCVv VDVSQEDPEVQFNWYVDGVEVHNAKTKP REEQFXaa₈₀STYRVVSVLTVLHQDWLNG KEYKCKVSNKGLPSSIEKTISKAKGQPR EPQVYTLPPSQEEMTKNQVSLTCLVKGF YPSDIAVEWESNGQPENNYKTTPPVLDS DGSFFLYSRLTVDKSRWQEGNVFSCSVM HEALHNHYTQKSLSLSLGXaa₂₃₀ wherein Xaa₁₆ is P or E Xaa₁₇ is F, V or A Xaa₁₈ is L, E or A Xaa₈₀ is N or A and Xaa₂₃₀ is K or absent 3204 (-GGGGS-)_(x) where x is 1, 2, Linker 3, 4, 5 or 6 3205 HGEGTFTSDVSSYLEEQAAKEFIAWLVK Fc portion of an immunogiobutin GGGGGGGSGGGGSGGGGSAESKYGPPCP PCPAPEAAGGPSVFLFPPFPKDTLMISR TPEVTCVVVDVSQEDPEVQFNWYVDGVE VHNAKTKPREEQFNSTYRVVSVLTVLHQ DWLNGKEYKCKVSNKGLPSSIEKTISKA KGQPREPQVYTLPPSQEEMTKNQVSLTC LVKGFYPSDIAVEWESNGQPENNYKTTP PVLDSDGSFFLYSR LTVDKSRWQEGNVFSCSVMHEALHNYHT QKSLSLSLG 3206 HXaa₈EGTFTSCVS GLP-1 analog SYLEXaa₂₂QAAKEFIAWLXaa₃₃KGGPSS GAPPPC₄₅C₄₆-Z, wherein Xaa₈ is: D-Ala, G, V, L, I, S, or T Xaa₂₂ is G, E, D or K Xaa₃₃ is: V or I and Z is OH or NH₂ and, optionally, wherein (i) one polyethylene glycol moiety is covalently attached to C₄₅, (ii) one polyethylene glycol moiety is covalently attached to C₄₆, or (iii) one polyethylene glycol moiety is attached to C₄₅ and one polyethylene glycol moiety is attached to C₄₆. 3207 HVEGTFTSDVSSYLEEQAAKEFIAWLIK GLP-1 analog GGPSSGAPPPC₄₅-C₄₆-NH₂ and, optionally, wherein (i) one polyethylene glycol moiety is covalently attached to C₄, (ii) one polyethylene glycol moiety is covalently attached to C₄₆, or (iii) one polyethylene glycol moiety is attached to C₄₅ and one polyethylene glycol moiety is attached to C₄₆ 3208 HGEGTFTSDLSKQMEEEAVKLFIEWLKN [N^(e)-(17-carboxyheptadecanoic GGPSSGAPPPS acid)Lys²⁰-]exendin-4-NH₂ 3209 HGEGTFTSDLSKQMEEEAVRLFIEWLKN [N^(e)-(17-carboxyheptadecanoyl) GGPKSGAPPPS Lys³²]exendin-4-NH₂ 3210 GEGTFTSDLSKQMEEEAVKLFIEWLKNG [desamino-His¹, N^(e)-(17- GPSSGAPPPS carboxyheptadecanoyl)Lys²⁰]exendin- 4-NH₂ 3211 HGEGTFTSDLSRQNorLeEEEAVRLFIE [Arg^(12,27), NLe¹⁴, N^(e)-(17-carboxy- WLRNGGPKSGAPPPS heptadecanoyl)Lys³²-]exendin-4- NH₂ 3212 HGEGTFTSDLSKQMEEEAVKLFIEWLKN [N^(e)-(19-carboxy- GGPSSGAPPPS nonadecanoylamino)Lys²⁰]- exendin-4-NH₂ 3213 HGEGTFTSDLSKQMEEEAVKLFIEWLKN [N^(e)-(15- GGPSSGAPPPS carboxypentadecanoylamino)Lys²⁰]- exendin-4-NH₂ 3214 HGEGTFTSDLSKQMEEEAVKLFIEWLKN [N^(e)-(13- GGPSSGAPPPS carboxytridecanoylamino)Lys²⁰] exendin-4-NH₂ 3215 HGEGTFTSDLSKQMEEEAVKLFIEWLKN [N^(e)-(11-carboxy-undecanoyl- GGPSSGAPPPS amino)Lys²⁰]exendin-4-NH₂ 3216 HGEGTFTSDLSKQMEEEAVRLFIEWLKN exendin-4-Lys⁴⁰(e-MPA)-NH₂ GGPSSGAPPPSK 3217 HGEGTFTSDLSKQMEEEAVRLFIEWLKN exendin-4-Lys⁴⁰(e-AEEA-AEEA- GGPSSGAPPPSK MPA)-NH₂ 3218 HGEGTFTSDLSKQMEEEAVRLFIEWLKN exendin-4-Lys⁴⁰(e-AEEA-MPA)- GGPSSGAPPPSK NH₂ 3219 HGEGTFTSDLSKQMEEEAVRLFIEWLKN exendin-4-Lys⁴⁰(e-MPA)-albumin GGPSSGAPPPSK 3220 HGEGTFTSDLSKQMEEEAVRLFIEWLKN exendin-4-Lys⁴⁰(e-AEEA-AEEA GGPSSGAPPPSK MPA)-albumin 3221 HGEGTFTSDLSKQMEEEAVRLFIEWLKN exendin-4-Lys⁴⁰(e-AEEA-MPA)- GGPSSGAPPPSK albumin 3222 AEGTFTSDVSSYLEGQAAREFIAWLVKG desamino-His⁷, Arg²⁶, Lys³⁴(N^(ϵ)-γ- RG Glu(N-α-hexadacanoyl)))-GLP- 1(7-37)(core peptide disclosed as SEQ ID NO: 3222) 3223 AEGTFTSDVSSYLEGQAAREFIAWLVKG desamino-His⁷, Arg²⁶, Lys³⁴(N^(ϵ)- RG octanoyl)-GLP-1(7-37) 3224 HAEGTFTSDVSSYLEGQAAREFIAWLVR Arg^(26,34), Lys³⁸(N^(ϵ)-ω- GRGK carboxypentadecanoyl))-GLP-1(7- 38) 3225 HAEGTFTSDVSSYLEGQAAREFIAWLVR Arg^(26,34), Lys³⁶(N^(ϵ)-γ-Glu(N-α- GRGK hexadecanoyl)))-GLP-1(7-36) (core peptide disclosed as SEQ ID NO: 3225) 3226 H[Aib]EGTFTSDVSSYLEGQAAKEFIA [Aib⁸; Lys³⁷]GLP-1_(7-37) WLVKGRK 3227 H[Aib]EGTFTSDVSSYLEGQAAKEFIA [Aib⁸; Lys³⁶]GLP-1_(7-37) WLVKGKG 3228 H[Aib]EGTFTSDVSSYLE[Aib]QAAK [Aib^(8,22); Lys³⁶]GLP-1(7-36)- EFIAWLVKGK Amide 3229 H[Aib]EGTFTSDVSSYLE[Aib]QAAK [Aib^(8,22); BLeu³²; Lys³⁶]GLP-1(7- EFIAW[BLeu]VKGK 36)-Amide 3230 H[Aib]EGTFTSDVSSYLE[Aib]QAAK [Aib^(8,22); Lys³⁷]GLP-1(7-37)- EFIAWLVKGRK Amide 3231 H[Aib]EGTFTSDVSSYLE[Aib]QAAK [Aib^(8,22); BLeu³²; Lys³⁷]GLP-1(7- EFIAW[BLeu]VKGRK 37)-Amide 3232 H[Aib]EGTFTSDVSSYLE[Aib]QAAK [Aib^(8,22); aMeLeu³²; Lys³⁷]GLP-1(7- EFIAW[aMeLeu]VKGRK 37)-Amide 3233 H[Aib]EGT[AMEF]TSDVSSYLE[Aib] [Aib^(8,22); AMEF¹²; Lys³⁷]GLP-1(7- QAAKEFIAWLVKGRK 37)-Amide 3234 H[Aib]EGTFTSD[BLeu]SSYLE[Aib] [Aib^(8,22); BLeu¹⁶; Lys³⁷]GLP-1(7- QAAKEFIAWLVKGRK  37)-Amide 3235 H[Aib]EGTFTSDVSSYLE[Aib]QAAK [Aib^(8,22); Gly³⁶; Lys³⁷]GLP-1(7-37)- EFIAWLVKGGK Amide 3236 H[Aib]EGTFTSDVSSYLE[Aib]QAAK [Aib^(8,22); Lys^(33,37); Asn³⁴; Gly³⁶]GLP- EFIAWLKNGGK 1(7-37)-Amide 3237 H[Aib]EGTFTSDVSSYLE[Aib]QAAK EFIAWLKNGG[Aeea] GLP-1(7-37)-AEEA-Lys-Amide 3238 H[Aib]EGTFTSDVSSYLE[Aib]QAAK [Aib^(8,22); Gly³⁶]GLP-1(7-37) EFIAWLVKGGG 3239 H[Aib]EGTFTSDVSSYLEGEAAKKFIA cyclo[E²³-K²⁷][Aib⁸; Gly³⁶]GLP- WLVKGGG 1(7-37) 3240 H[Aib]EGTFTSDVSSYLEEQAAKEKFI cyclo[E²²- AWLVKGGK K²⁶][Aib⁸; Gly³⁶; Lys37]GLP-1(7- 37)-Amide 3241 H[Aib]EGTFTSDVSSYLE[Aib]EAVR [Aib^(8,22)]-GLP-1(7-22)-Ex4(17-39) LFIEWLKNGGPSSGAPPPS 3242 HGEGTFTSDVSSYLEEQAAKEFIAWLVK [Gly^(8,36); Glu²²]GLP-1(7-37) GGG 3243 H[Aib]EGTFTSDVSSYLEEQAAKEFIA [Aib⁸; Glu²²; Gly³⁶]GLP-1(7-37)- WLVKGGG Amide 3244 H[Aib]EGTFTSDYSSYLEEQAAKEFIA [Aib⁸; Tyr¹⁶; Glu²²; Gly³⁶]GLP- WLVKGGG 1(7-37) 3245 H[Aib]EGTFTSDVSKYLEEEAVRLFIE [Aib⁸; Lys^(18,33); Glu^(22,23,30); Val²⁵; Arg²⁶; WLKNGGG Leu²⁷; Asn³⁴; Gly³⁶]GLP-1(7-37) 3246 H[Aib]EGTFTSDVSKYLEEEAAKLFIE [Aib⁸; Lys^(18,33); Glu^(22,23,30); Leu²⁷; Asn³⁴; WLKNGGG Gly³⁶]GLP-1(7-37) 3247 H[Aib]EGTFTSDVSKYLEEEAAKLFIE [Aib⁸; Lys¹⁸; Glu^(22,23,30); Leu²⁷; Glu³⁶] WLVKGGG GLP-1(7-37) 3248 H[Aib]IGTFTSDVSSYLE[Aib]QAAK [Aib^(8,22); Ile⁹; Gly³⁶]GLP-1_(7-36) EFIAWLVKGG 3249 H[Aib]EGTFTSEVSSYLE[Aib]QAAK [Aib^(8,22); Glu¹⁵; Gly³⁶]GLP-1_(7-36) EFIAWLVKGG 3286 {H2}H[Aib]EGTFTSDVSSYLE[Aib] QAAKEFIAWLKNGG[Aeea][Aeea]K {CONH2} 3287 {H2}H[Aib]EGTFTSDVSSYLE[Aib] QAAKEFIAWLVKGGG 3288 {H2}H[Aib]EGTFTSDVSSYLEGEAAK KFIAWLVKGGG 3289 {H2}H[Aib]EGTFTSDVSSYLEEQAAK EFIAWLVKGGK{CONH2} 3290 {H2}H[Aib]EGTFTSDVSSYLE[Aib] EAVRLFIEWLKNGGPSSGAPPPS 3291 {H2}HGEGTFTSDVSSYLEEQAAKEFIA WLVKGGG 3292 {H2}H[Aib]EGTFTSDVSSYLEEQAAK EFIAWLVKGGG 3293 {H2}H[Aib]EGTFTSDYSSYLEEQAAK EFIAWLVKGGG 3294 {H2}H[Aib]EGTFTSDVSKYLEEEAVR LFIEWLKNGGG 3295 {H2}H[Aib]EGTFTSDVSKYLEEEAAK LFIEWLKNGGG 3296 {H2}H[Aib]EGTFTSDVSKYLEEEAAK LFIEWLVKGGG 3297 {H2}H[Aib]IGTFTSDVSSYLE[Aib] QAAKEFIAWLVKGG 3298 {H2}H[Aib]EGTFTSEVSSYLE[Aib] QAAKEFIAWLVKGG 3299 {H2}H[Aib]AGTFTSDVSSYLE[Aib] QAAKEFIAWLVKGG 3300 {H2}H[Aib]EGTFTSDVSSYLE[Aib] QAAKEFAAWLVKGG 3301 {H2}H[Aib]EGTFTSDVSSYLE[Aib] QAAKEFIAALVKGG 3302 {H2}H[Aib]TGTFTSDVSSYLE[Aib] QAAKEFIAWLVKGGG 3303 {H2}H[Aib]EGTFTSEVSSYLE[Aib] QAAKEFIAALVKGGG 3304 {H2}H[Aib]EGTFTSDVSSYLE[Aib] QAAKEFIAALVKGGG 3305 {H2}H[Aib]EGTFTSDVSSYLEEEAVR LFIEWLKNGGPSSGAPPPS 3306 {H2}H[Aib]EGTFTSDYSSYLE[Aib] QAAKEFIAWLVKGGG 3307 {H2}H[Aib]EGTFTSDVSSYLE[Aib] QAAKEFIAWLVKGGG{CONH2} 3308 {Dmia}SQGTFTSDYSKYLDERRAKDFV QWLMNT 3309 {H2}HGEGTFTSDLSKQMEEEAVRLFIE WLKNGGPSSGAPPPS

AEEA refers to [2-(2-amino)ethoxy)]acetic acid

EDA refers to ethylenediamine.

MPA refers to maleimidopropionic acid.

The disclosure also provides pharmaceutical compositions comprising the GLP-1 receptor agonist compounds described herein and a pharmaceutically acceptable carrier. The GLP-1 receptor agonist compounds can be present in the pharmaceutical composition in a therapeutically effective amount and can be present in an amount to provide a minimum blood plasma level of the GLP-1 receptor agonist compound necessary for therapeutic efficacy. Such pharmaceutical compositions are known in the art and described, e.g., in U.S. Pat. Nos. 7,521,423; 7,456,254; WO 2000/037098; WO 2005/021022; WO 2005/102293; WO 2006/068910; WO 2006/125763; WO 2009/068910; US Publication No. 2004/0106547; and the like, the disclosures of which are incorporated herein by reference.

Pharmaceutical compositions containing the GLP-1 receptor agonist compounds described herein may be provided for peripheral administration, such as parenteral (e.g., subcutaneous, intravenous, intramuscular), a continuous infusion (e.g., intravenous drip, intravenous bolus, intravenous infusion), topical, nasal, or oral administration. Suitable pharmaceutically acceptable carriers and their formulation are described in standard formulation treatises, such as Remington's Pharmaceutical Sciences by Martin; and Wang et al., Journal of Parenteral Science and Technology, Technical Report No. 10, Supp. 42:2S (1988). The GLP-1 receptor agonist compounds described herein can be provided in parenteral compositions for injection or infusion. They can, for example, be suspended in water; an inert oil, such as a vegetable oil (e.g., sesame, peanut, olive oil, and the like); or other pharmaceutically acceptable carrier. In one embodiment, the compounds are suspended in an aqueous carrier, for example, in an isotonic buffer solution at a pH of about 3.0 to 8.0, or about 3.0 to 5.0. The compositions may be sterilized by conventional sterilization techniques or may be sterile filtered. The compositions may contain pharmaceutically acceptable auxiliary substances as required to approximate physiological conditions, such as pH buffering agents.

Useful buffers include for example, acetic acid buffers. A form of repository or “depot” slow release preparation may be used so that therapeutically effective amounts of the preparation are delivered into the bloodstream over many hours or days following subcutaneous injection, transdermal injection or other delivery method. The desired isotonicity may be accomplished using sodium chloride or other pharmaceutically acceptable agents such as dextrose, boric acid, sodium tartrate, propylene glycol, polyols (such as mannitol and sorbitol), or other inorganic or organic solutes. In one embodiment for intravenous infusion, the formulation may comprise (i) the GLP-1 receptor agonist compound, (2) sterile water, and, optionally (3) sodium chloride, dextrose, or a combination thereof.

Carriers or excipients can also be used to facilitate administration of the GLP-1 receptor agonist compounds. Examples of carriers and excipients include calcium carbonate, calcium phosphate, various sugars such as lactose, glucose, or sucrose, or types of starch, cellulose derivatives, gelatin, vegetable oils, polyethylene glycols and physiologically compatible solvents.

The GLP-1 receptor agonist compounds can also be formulated as pharmaceutically acceptable salts (e.g., acid addition salts) and/or complexes thereof. Pharmaceutically acceptable salts are non-toxic salts at the concentration at which they are administered. Pharmaceutically acceptable salts include acid addition salts such as those containing sulfate, hydrochloride, phosphate, sulfamate, acetate, citrate, lactate, tartrate, methanesulfonate, ethanesulfonate, benzenesulfonate, p-toluenesulfonate, cyclohexylsulfamate and quinate. Pharmaceutically acceptable salts can be obtained from acids such as hydrochloric acid, sulfuric acid, phosphoric acid, sulfamic acid, acetic acid, citric acid, lactic acid, tartaric acid, malonic acid, methanesulfonic acid, ethanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, cyclohexylsulfamic acid, and quinic acid. Such salts may be prepared by, for example, reacting the free acid or base forms of the product with one or more equivalents of the appropriate base or acid in a solvent or medium in which the salt is insoluble, or in a solvent such as water which is then removed in vacuo or by freeze-drying or by exchanging the ions of an existing salt for another ion on a suitable ion exchange resin.

Exemplary pharmaceutical formulations of GLP-1 receptor agonist compounds are described in U.S. Pat. Nos. 7,521,423, 7,456,254; US Publication No 2004/0106547, WO 2006/068910, WO 2006/125763, and the like, the disclosures of which are incorporated by reference herein.

The therapeutically effective amount of the GLP-1 receptor agonist compounds described herein for use in the methods described herein will typically be from about 0.01 μg to about 5 mg; about 0.1 μg to about 2.5 mg; about 1 μg to about 1 mg; about 1 μg to about 50 μg; or about 1 μg to about 25 μg. Alternatively, the therapeutically effective amount of the GLP-1 receptor agonist compounds may be from about 0.001 μg to about 100 μg based on the weight of a 70 kg patient; or from about 0.01 μg to about 50 μg based on the weight of a 70 kg patient. These therapeutically effective doses may be administered once/day, twice/day, thrice/day, once/week, biweekly, or once/month, depending on the formulation. The exact dose to be administered is determined, for example, by the formulation, such as an immediate release formulation or an extended release formulation. For transdermal, nasal or oral dosage forms, the dosage may be increased from about 5-fold to about 10-fold.

In certain embodiments the GLP-1 receptor agonist will be administered concurrently with the GIPR antigen binding protein. In one embodiment the GLP-1 receptor agonist will be administered after the GIPR antigen binding protein. In one embodiment the GLP-1 receptor agonist will be administered before the GIPR antigen binding protein. In certain embodiments the subject or patient will already be being treated with a GLP-1 receptor agonist before being subjected to further treatment with a GIPR antigen binding protein.

The GIPR antigen binding proteins that are provided herein are useful for detecting GIPR in biological samples. For instance, the GIPR antigen binding proteins can be used in diagnostic assays, e.g., binding assays to detect and/or quantify GIPR expressed in serum.

The antigen binding proteins of the described can be used for diagnostic purposes to detect, diagnose, or monitor diseases and/or conditions associated with GIPR. The disclosed antigen binding proteins provide a means for the detection of the presence of GIPR in a sample using classical immunohistological methods known to those of skill in the art (e.g., Tijssen, 1993, Practice and Theory of Enzyme Immunoassays, Vol 15 (Eds R. H. Burdon and P. H. van Knippenberg, Elsevier, Amsterdam); Zola, 1987, Monoclonal Antibodies: A Manual of Techniques, pp. 147-158 (CRC Press, Inc.); Jalkanen et al., 1985, J. Cell. Biol. 101:976-985; Jalkanen et al., 1987, J. Cell Biol. 105:3087-3096). The detection of GIPR can be performed in vivo or in vitro.

Diagnostic applications provided herein include use of the antigen binding proteins to detect expression of GIPR. Examples of methods useful in the detection of the presence of GIPR include immunoassays, such as the enzyme linked immunosorbent assay (ELISA) and the radioimmunoassay (RIA).

For diagnostic applications, the antigen binding protein typically will be labeled with a detectable labeling group. Suitable labeling groups include, but are not limited to, the following: radioisotopes or radionuclides (e.g., ³H, ¹⁴C, ¹⁵N, ³⁵S, ⁹⁰Y, ⁹⁹Tc, ¹¹¹In, ¹²⁵I, ¹³¹I), fluorescent groups (e.g., FITC, rhodamine, lanthanide phosphors), enzymatic groups (e.g., horseradish peroxidase, β-galactosidase, luciferase, alkaline phosphatase), chemiluminescent groups, biotinyl groups, or predetermined polypeptide epitopes recognized by a secondary reporter (e.g., leucine zipper pair sequences, binding sites for secondary antibodies, metal binding domains, epitope tags). In some embodiments, the labeling group is coupled to the antigen binding protein via spacer arms of various lengths to reduce potential steric hindrance. Various methods for labeling proteins are known in the art and may be used.

In some embodiments, the GIPR antigen binding protein is isolated and measured using techniques known in the art. See, for example, Harlow and Lane, 1988, Antibodies: A Laboratory Manual, New York: Cold Spring Harbor (ed. 1991 and periodic supplements); John E. Coligan, ed., 1993, Current Protocols In Immunology New York: John Wiley & Sons.

Another aspect of the disclosed provides for detecting the presence of a test molecule that competes for binding to GIPR with the antigen binding proteins provided. An example of one such assay would involve detecting the amount of free antigen binding protein in a solution containing an amount of GIPR in the presence or absence of the test molecule. An increase in the amount of free antigen binding protein (i.e., the antigen binding protein not bound to GIPR) would indicate that the test molecule is capable of competing for GIPR binding with the antigen binding protein. In one embodiment, the antigen binding protein is labeled with a labeling group. Alternatively, the test molecule is labeled and the amount of free test molecule is monitored in the presence and absence of an antigen binding protein.

GIPR binding proteins can be used to treat, diagnose or ameliorate, a metabolic condition or disorder. In one embodiment, the metabolic disorder to be treated is diabetes, e.g., type 2 diabetes. In another embodiment, the metabolic condition or disorder is obesity. In other embodiments the metabolic condition or disorder is dyslipidemia, elevated glucose levels, elevated insulin levels or diabetic nephropathy. For example, a metabolic condition or disorder that can be treated or ameliorated using a GIPR binding peptide includes a state in which a human subject has a fasting blood glucose level of 125 mg/dL or greater, for example, 130, 135, 140, 145, 150, 155, 160, 165, 170, 175, 180, 185, 190, 195, 200 or greater than 200 mg/dL. Blood glucose levels can be determined in the fed or fasted state, or at random. The metabolic condition or disorder can also comprise a condition in which a subject is at increased risk of developing a metabolic condition. For a human subject, such conditions include a fasting blood glucose level of 100 mg/dL. Conditions that can be treated using a pharmaceutical composition comprising a GIPR binding protein can also be found in the American Diabetes Association Standards of Medical Care in Diabetes Care-2011, American Diabetes Association, Diabetes Care Vol. 34, No. Supplement 1, S11-S61, 2010, incorporated herein by reference.

In application, a metabolic disorder or condition, such as Type 2 diabetes, elevated glucose levels, elevated insulin levels, dyslipidemia, obesity or diabetic nephropathy, can be treated by administering a therapeutically effective dose of a GIPR binding protein to a patient in need thereof. The administration can be performed as described herein, such as by IV injection, intraperitoneal (IP) injection, subcutaneous injection, intramuscular injection, or orally in the form of a tablet or liquid formation. In some situations, a therapeutically effective or preferred dose of a GIPR binding protein can be determined by a clinician. A therapeutically effective dose of GIPR binding protein will depend, inter alia, upon the administration schedule, the unit dose of agent administered, whether the GIPR binding protein is administered in combination with other therapeutic agents, the immune status and the health of the recipient. The term “therapeutically effective dose,” as used herein, means an amount of GIPR binding protein that elicits a biological or medicinal response in a tissue system, animal, or human being sought by a researcher, medical doctor, or other clinician, which includes alleviation or amelioration of the symptoms of the disease or disorder being treated, i.e., an amount of a GIPR binding protein that supports an observable level of one or more desired biological or medicinal response, for example lowering blood glucose, insulin, triglyceride, or cholesterol levels; reducing body weight; or improving glucose tolerance, energy expenditure, or insulin sensitivity.

It is noted that a therapeutically effective dose of a GIPR binding protein can also vary with the desired result. Thus, for example, in situations in which a lower level of blood glucose is indicated a dose of GIPR binding protein will be correspondingly higher than a dose in which a comparatively lower level of blood glucose is desired. Conversely, in situations in which a higher level of blood glucose is indicated a dose of GIPR binding protein will be correspondingly lower than a dose in which a comparatively higher level of blood glucose is desired.

In various embodiments, a subject is a human having a blood glucose level of 100 mg/dL or greater can be treated with a GIPR binding protein.

In one embodiment, a method of the instant disclosure comprises first measuring a baseline level of one or more metabolically-relevant compounds such as glucose, insulin, cholesterol, lipid in a subject. A pharmaceutical composition comprising a GIPR binding protein is then administered to the subject. After a desired period of time, the level of the one or more metabolically-relevant compounds (e.g., blood glucose, insulin, cholesterol, lipid) in the subject is again measured. The two levels can then be compared in order to determine the relative change in the metabolically-relevant compound in the subject. Depending on the outcome of that comparison another dose of the pharmaceutical composition comprising a GIPR binding protein can be administered to achieve a desired level of one or more metabolically-relevant compound.

It is noted that a pharmaceutical composition comprising a GIPR binding protein can be co-administered with another compound. The identity and properties of compound co-administered with the GIPR binding protein will depend on the nature of the condition to be treated or ameliorated. A non-limiting list of examples of compounds that can be administered in combination with a pharmaceutical composition comprising a GIPR binding protein include rosiglitizone, pioglitizone, repaglinide, nateglitinide, metformin, exenatide, stiagliptin, pramlintide, glipizide, glimeprirideacarbose, and miglitol.

Also provided are kits for practicing the disclosed methods. Such kits can comprise a pharmaceutical composition such as those described herein, including nucleic acids encoding the peptides or proteins provided herein, vectors and cells comprising such nucleic acids, and pharmaceutical compositions comprising such nucleic acid-containing compounds, which can be provided in a sterile container. Optionally, instructions on how to employ the provided pharmaceutical composition in the treatment of a metabolic disorder can also be included or be made available to a patient or a medical service provider.

In one aspect, a kit comprises (a) a pharmaceutical composition comprising a therapeutically effective amount of a GIPR binding protein; and (b) one or more containers for the pharmaceutical composition. Such a kit can also comprise instructions for the use thereof; the instructions can be tailored to the precise metabolic disorder being treated. The instructions can describe the use and nature of the materials provided in the kit. In certain embodiments, kits include instructions for a patient to carry out administration to treat a metabolic disorder, such as elevated glucose levels, elevated insulin levels, obesity, type 2 diabetes, dyslipidemia or diabetic nephropathy.

Instructions can be printed on a substrate, such as paper or plastic, etc, and can be present in the kits as a package insert, in the labeling of the container of the kit or components thereof (e.g., associated with the packaging), etc. In other embodiments, the instructions are present as an electronic storage data file present on a suitable computer readable storage medium, e.g. CD-ROM, diskette, etc. In yet other embodiments, the actual instructions are not present in the kit, but means for obtaining the instructions from a remote source, such as over the internet, are provided. An example of this embodiment is a kit that includes a web address where the instructions can be viewed and/or from which the instructions can be downloaded.

Often it will be desirable that some or all components of a kit are packaged in suitable packaging to maintain sterility. The components of a kit can be packaged in a kit containment element to make a single, easily handled unit, where the kit containment element, e.g., box or analogous structure, may or may not be an airtight container, e.g., to further preserve the sterility of some or all of the components of the kit.

Example 1

Generation of Bis-Cysteamine-Capped Anti-GIPR cys mAb (2 g Scale)

The reaction scheme for the generation of anti-GIPR/GLP-1 peptide conjugates is shown in FIG. 1. Anti-GIPR monoclonal antibodies with specific cysteine mutation (anti-GIPR cys mAb, 2 g) was incubated with 800 mL solution of 2.5 mM cystamine and 2.5 mM cysteamine in 40 mM HEPES buffer, pH 7.5-8.5 for 15-20 h. The reaction mixture was filtered using 0.22 μm filter, and diluted in 1200 mL of 100 mM sodium acetate buffer pH 5. Cation exchange chromatography was used to purify the bis-cysteamine-capped anti-GIPR cys mAb from the reaction mixture. First, 2 L of reaction mixture diluted in 100 mM sodium acetate buffer pH 5 was loaded onto 240 mL SP HP column at 20 mL/min. The column was washed with 2 column volumes of 100 mM sodium acetate pH 5, followed by a 0-20% gradient of 100 mM sodium acetate with 1.2 M NaCl pH 5. The main peak containing bis-cysteamine-capped anti-GIPR cys mAb was collected and buffer exchanged to 10 mM sodium acetate with 9% sucrose pH 5.2 using tangential flow filtration.

Example 2

Generation of Anti-GIPR/GLP-1 Peptide Conjugates

Bis-cysteamine-capped anti-GIPR cys mAb (6 mg/mL in 10 mM sodium acetate with 9% sucrose) was partially reduced using 3-4 equivalents of tris(2-carboxyethyl)phosphine (TCEP) at RT for 60-90 min. TCEP was removed, and partially reduced cys mAb was buffer exchanged to 50 mM sodium phosphate buffer containing 2 mM ethylenediaminetetraacetic acid (EDTA) pH 7.5. To the partially reduced cys mAb was added 6-10 equivalents of dehydroascorbic acid (DHAA), and oxidation was carried out at RT until only trace amount of partially reduced mAb species were observed (30-120 min). Without removing dhAA, 3-8 equivalents of bromoacetyl-GLP-1 peptides was added to the reaction mixture and incubated at RT for 15-20 h. All the reagents were removed, and the anti-GIPR/GLP-1 peptide conjugate product was buffer exchanged to final formulation using spin concentration or tangential flow filtration.

TABLE 9 Anti-GIPR antagonist/GLP-1 receptor agonist bispecific conjugates constructs. hGLP-1 hGIPR Conjugate# Description Peptide information Site/linker IC₅₀(nM) IC₅₀(nM) 3159936#1 5G12-D88C- [Aib8, Lys26(SGGAcBr)]GLP-1 (7-37) Lys26/SGG 0.167 81.9 3156820 1140-1 5G12-D88C- [Aib8, Lys26(SGGAcBr)]GLP-1 (7-37) Lys26/SGG 0.059 101.6 3156820 1109-1 5G12-E384C- [Aib8, Lys26(SGGAcBr)]GLP-1 (7-37) Lys26/SGG 0.622 44.9 3156820 DAR1 1110-1 5G12-E384C- [Aib8, Lys26(SGGAcBr)]GLP-1 (7-37) Lys26/SGG 0.159 47.0 3156820 1118-1 5G12 SEFL2 D88C- [Aib8, Lys26(SGGAcBr)]GLP-1 (7-37) Lys26/SGG 0.143 61.2 3156820 DAR1 1135-1 5G12 T487C- [Aib8, Lys26(SGGAcBr)]GLP-1 (7-37) Lys26/SGG 0.065 50.6 3156820 1143-1 5G12-E384C- [Aib8,22; Gly36; Lys37(PEG1lAcBr)]GLP-1(7-37)- Lys37/PEG11 0.047 37.0 3161655 Amide 1144-1 5G12-E384C- [Aib8,22; Lys36(SGGACBr)]GLP-1(7-36)-Amide Lys36/SGG 0.036 37.9 3161021 1159-1 5G12-D88C- [Aib8,22; Gly36]GLP-1(7- C- 0.044 152.1 3166119 37)]GGGGSGGGGSGGGGSK(BrAc)1 term/(GGGGS)3 1160-1 5G12-E384C- [Aib8,22; Gly36]GLP-1(7- C- 0.171 43.5 3166119 37)]GGGGSGGGGSGGGGSK(BrAc)1 term/(GGGGS)3 1161-1 5G12-T4874C- [Aib8,22; Gly36]GLP-1(7- C- 0.032 41.3 3166119 37)]GGGGSGGGGSGGGGSK(BrAc)1 term/(GGGGS)3 1163-1 5G12-D88C- [Aib8; Glu22-Lys26; Gly36]GLP-1(7- C- 0.01 275.5 3157736 37)]GGGGSGGGGSGGGGSK(BrAc)1 term/(GGGGS)3 1164-1 5G12-E384C- [Aib8; Glu22-Lys26; Gly36]GLP-1(7- C- 0.053 26.8 3157736 37)]GGGGSGGGGSGGGGSK(BrAc)1 term/(GGGGS)3 1165-1 5G12-T487C- [Aib8; Glu22-Lys26; Gly36]GLP-1(7- C- 0.014 34 3157736 37)]GGGGSGGGGSGGGGSK(BrAc)1 term/(GGGGS)3 1172-1 5G12-E384C- cyclo[E22-K26][Aib8;Lys(NPeg11-BrAc)37]GLP-1 Lys37/PEG11 0.044 50 3169019 (7-37)-Amide 1198-1 5G12-E384C- [Aib8,22; Gly36; Lys(NPeg27-BrAc)37]GLP-1(7-37)- Lys37/PEG27 0.0329 98.5 3169018 Amide 1199-1 5G12-T487C- [Aib8,22; Gly36; Lys(NPeg27-BrAc)37]GLP-1(7-37)- Lys37/PEG27 0.006 84 3169018 Amide 1200-1 5G12-E384C- [Aib8; Glu23-Lys27; Gly36]GLP-1(7- C- 0.045 40.4 3172563 37)[GGGGSGGGGSGGGGSK(BrAc)] term/(GGGGS)3 1201-1 5G12-T487C- [Aib8; Glu23-Lys27; Gly36]GLP-1(7- C- 0.011 35 3172563-DAR2 37)[GGGGSGGGGSGGGGSK(BrAc)] term/(GGGGS)3 1202-1 5G12-T487C- [Aib8; Glu23-Lys27; Gly36]GLP-1(7- C- 0.01 30 3172563-DAR1 37)[GGGGSGGGGSGGGGSK(BrAc)] term/(GGGGS)3 1203-1 5G12-T487C- [Aib8; Glu22-Lys26; Gly36]GLP-1(7- C- 0.0072 45.4 3167736-DAR1 37)[GGGGSGGGGSGGGGSK(BrAc)] term/(GGGGS)3 1227-1 5G12-E384C- [Aib8,22]-GLP-1(7-22)-Ex4(17- C- 0.0236 96.5 3173043 39)[GGGGSGGGGSGGGGSK(BrAc)] term/(GGGGS)3 1228-1 5G12-E384C- [Aib8,22; Gly36[GLP-1(7-37)-]K2015-Lys(BrAc) C-term/1Kmod 0.0306 103.8 3173044 1229-1 5G12-E384C- Exendin-4(1-39)[GGGGSGGGGSGGGGSK(BrAc)] C- 0.013 84.9 3340181 term/(GGGGS)3 1230-1 5G12-E384C- [Gly8,36; Glu22]GLP-1(7- C- 0.0376 92.2 3340577 37)[GGGGSGGGGSGGGGSK(BrAc)] term/(GGGGS)3 1231-1 5G12-E384C- [Aib8; Glu22; Gly36]GLP-1(7- C- 0.0297 101.9 3340578 37)[GGGGSGGGGSGGGGSK(BrAc)] term/(GGGGS)3 1233-1 aGIPR 5G12 E384C [Aib8,22; Glu15; Gly36; Lys]GLP-1(7-37)-(G4S)3K C- 0.118 121 Ab-3342048 (BrAc)-amide term/(GGGGS)3 1234-1 aGIPR 5G12 E384C [Aib8,22; Gly36]GLP-1(7-37)-(G4S)2K(BrAc)-amide Lys37(C- 0.0446 108 Ab-3341281 term)/(GGGGS)2 1235-1 aGIPR 5G12 E384C [Aib8,22;Gly36]GLP-1(7-37)-AS(AP)5GSK(BrAc)-amide C- 0.0311 122 Ab-3341282 term/AS(AP)5GS 1237-1 aGIPR 5G12 SEFL2 [Aib8,22;Gly36]GLP-1(7-37)-Pro-Ser-Ser-Gly-Ala- C- 0.0226 83.5 E384C-3341284 Pro-Pro-Pro-Ser-(G4S)2K(AcBr) term/(GGGGS)2 1238-1 aGIPR 5G12 SEFL2 [Aib8; Tyr16; Glu22; Gly36]GLP-1_(7-37)-(G4S)3-K C- 0.0046 82.8 E384C-3341285 (AcBr) term/(GGGGS)3 1239-1 aGIPR 6H1 SEFL2 [Aib8,22; Gly36]GLP-1(7-37)-G4S3-Lys(BrAc) C- 0.126 34.3 E384C-3166119 term/(GGGGS)3 1240-1 aGIPR 5G12 SEFL2 [Aib8,22; Ile9; Gly36]GLP-1_(7-36)-(G4S)3-K(AcBr) C- 0.0552 111 E384C-3342047 term/(GGGGS)3 1241-1 aGIPR 5G12 SEFL2 [Aib8,22; Ala9; Gly36]GLP-1_(7-36)-(G4S)3-K(AcBr) C- 0.0549 92.3 E384C-3342049 term/(GGGGS)3 1242-1 aGIPR 5G12 SEFL2 [Aib8,22; Ala29; Gly36]GLP-1_(7-36)-(G4S)3-K(AcBr) C- 0.173 92.4 E384C-3342050 term/(GGGGS)3 1243-1 aGIPR 5G12 SEFL2 [Aib8,22; Ala31; Gly36]GLP-1_(7-36)-(G4S)3-K(AcBr) C- 1.147 75.9 E384C-3342051 term/(GGGGS)3 1248-1 aGIPR 2G10 SEFL2 [Aib8,22; Gly36]GLP-1(7-37)[GGGGSGGGGSGGGGS(BrAc)] C- 0.015 68.9 E384C-3166119 term/(GGGGS)3 aGIPR 5G12 SEFL2 [Aib8,22; Thr9; Gly36]GLP-1_(7-37)-(G4S)3-K(AcBr) C- 0.069 85 1250-1 E384C-3343106 term/(GGGGS)3 aGIPR 5G12 SEFL2 [Aib8,22; Glu15; Ala31; Gly36]GLP-1_(7-37)-(G4S)3- C- 0.32 85 1251-1 E384C-3343109 K(AcBr) term/(GGGGS)3 aGIPR 5G12 SEFL2 [Aib8,22; Ala31; Gly36]GLP-1_(7-37)-(G4S)3-K(AcBr) C- 0.2 78.8 1252-1 E384C-3343110 term/(GGGGS)3 1253-1 aGIPR 5G12 SEFL2 [Aib8,22; LysG4S3G(AcBr)26; Gly36]GLP-1_(7-37) Lys26/(GGGGS)3 0.0013 77.4 E384C-3343906 1253-2 aGIPR 5G12 SEFL2 [Aib8,22; LysG4S3G(AcBr)26; Gly36]GLP-1_(7-37) Lys26/(GGGGS)3 0.0084 51.4 E384C-3343906 1254-1 aGIPR 5G12 SEFL2 [Aib8,22; Tyr16; Gly36]GLP-1_(7-37)-(G4S)3-K(AcBr) C- 0.0058 73.8 E384C-3343905 term/(GGGGS)3 1255-1 aGIPR 2G10 SEFL2 [Aib8,22; Gly36]GLP-1(7-37)-G4S2K(BrAc) C- 0.026 56.4 E384C-3341281 term/(GGGGS)2 1256-1 aGIPR 2G10 SEFL2 [Aib8,22; Thr9; Gly36]GLP-1(7-37)-G4S2K(BrAc) C- 0.104 66 E384C-3343106 term/(GGGGS)3 1257-1 aGIPR 2G10 SEFL2 [Aib8, Glu22; Gly36]GLP-1(7-37)-G4S3-K(BrAc) C- 0.011 66 E384C-3340578 term/(GGGGS)3 1258-1 2G10 SEFL2 E384C- [Aib8,22; Glu15; Ala31; Gly36]GLP-1_(7-37)-(G4S)3- C- 3.58 53.9 3343109 K(AcBr) term/(GGGGS)3 1261-1 2G10 SEFL2 E384C- [Aib8,22; Ala31; Gly36]GLP-1_(7-37)-(G4S)3-K(AcBr) C- 0.096 41.9 3343110 term/(GGGGS)3 1262-1 aGIPR 2G10 SEFL2 [Aib8,22; Tyr16; Gly36]GLP-1_(7-37)-(G4S)3-K(AcBr) C- 0.0347 52.9 E384C-3343905 term/(GGGGS)3 1263-1 aGIPR 2G10 SEFL2 [Aib8,22; LysG4S3G(AcBr)26;Gly36]GLP-1_(7-37) Lys26/(GGGGS)3 0.0143 48.7 E384C-3343906 1264-1 2G10 SEFL2 E384C- [Aib8,22; Glu15; Gly36]GLP-1_(7-37)-(G4S)3-K(AcBr) C- 0.0459 48.6 3344713 term/(GGGGS)3 1264-2 2G10 SEFL2 E384C- [Aib8,22; Glu15; Gly36]GLP-1 (7-37)-(G4S)3-K(AcBr) C- 0.112 40.3 3344713 term/(GGGGS)3 1265-1 2G10 SEFL2 E384C- [Aib8,22; Tyr16; Gly36]GLP-1 C- 0.0439 50.4 3344748 (7-37)-(GGGGSGG)-K(AcBr) term/GGGGSGG 1265-2 2G10 SEFL2 E384C- [Aib8,22; Tyr16; Gly36]GLP-1 C- 0.177 50.4 3344748 (7-37)-(GGGGSGG)-K(AcBr) term/GGGGSGG 1267-1 aGIPR 2G10 SEFL2 cyclo[E22-K26][Aib8;(NPeg11-BrAc)37]GLP-1(7-37)- Lys37/PEG11 0.004 49.3 E384C-3169019 Amide 1269-1 aGIPR 5G12 SEFL2- [Aib8,22; Glu15; Gly36]GLP-1_(7-37)-(G4S)3-K(AcBr) C- 0.0169 57.4 E384C-3344713 term/(GGGGS)3 1270-1 aGIPR 5G12 SEFL2- [Aib8,22; Tyr16; Gly36]GLP-1_(7-37)-(GGGGSGG)-K C- 0.0298 50.9 E384C-3344748 (AcBr) term/(GGGGS)3 1272-1 aGIPR 2G10 SEFL2- [Aib8,22; Gly3]GLP-1_(7-37)-PEG11-AcBr Lys37/PEG11 0.055 53 E384C-3161655 1273-1 aGIPR 2G10 SEFL2- [Aib8; Tyr16; Glu22; Gly36]GLP-1_(7-37)-(GGGGSGG)- C- 0.061 42.3 E384C-3341285 K(AcBr) term/(GGGGS)3 1274-1 aGIPR 2G10 SEFL2- [Aib8,22]-GLP-1(7-22)-Ex4(17-39)-(G4S)K-BrAc C-term/(GGGGS) 0.199 36.4 E384C-3345837 1281-1 aGIPR 2G10 SEFL2- [Aib8,22]-GLP-1(7-22)-Ex4(17-39)-(G4S)2K-BrAc C- 0.177 47.9 E384C-3345836 term/(GGGGS)2 1282-1 aGIPR 2G10 SEFL2- [Aib8,22]-GLP-1(7-22)-Ex4(17-39)-(G4S)3K-BrAc C- 0.094 43.9 E384C-3173043 term/(GGGGS)3 1283-1 aGIPR 5G12 SEFL2- [Aib8,22]-GLP-1(7-22)-Ex4(17-39)-(G4S)2K-BrAc C- 0.139 67.8 E384C-3345836 term/(GGGGS)2 1284-1 aGIPR 5G12 SEFL2- [Aib8,22]-GLP-1(7-22)-Ex4(17-39)-(G4S)K-BrAc C-term/(GGGGS) 0.154 63.8 E384C-3345837

Example 3

Methods for In Vitro and In Vivo Assay

GLP-1 Receptor Agonist Activity

CHOK1 cells stably expressing the human GLP-1R alone or both GLP-1R and GIPR (M1) were used to measure peptide/conjugate-induced cAMP production in a homogeneous time-resolved fluorescence (HTRF) assay (CISBIO, cat #62AM4PEJ). Serial diluted peptides/conjugates (3×10⁻⁷ M-3×10⁻¹⁴ M) were incubated with 40,000 cells in assay buffer (0.1% BSA, 500 uM IBMX in F12 media) for 15 min at 37° C. Cells were then lysed with lysis buffer containing cAMP-d2 and cAMP cryptate (CISBIO) and incubated for 1 hour at room temperature before measured in Evision plate reader (PerkinElmer). The cAMP levels are expressed as a fluorescence ratio of 665/620 nm and shown in FIGS. 2A-2E and FIG. 3.

Example 4

GIPR Antagonist Activity

HEK 293T cells stably expressing the human GIPR were used to measure peptide/conjugate-induced cAMP generation in HTRF assay (Cisbio, cat #62AM4PEJ). Serial diluted conjugates or GIPR antibody (3×10⁻⁶ M-1×10⁻¹¹ M) were incubated with 30,000 cells in assay buffer (0.1% BSA, 500 uM IBMX in F12 media) for 30 min at 37° C. before being treated with GIP at final concentration of 0.05 nM. Cells were incubated for 30 min at 37° C. and then lysed in lysis buffer containing cAMP-d2 and cAMP cryptate (CISBIO) for 1 hour at room temperature. The fluorescence was measured in Evision plate reader (PerkinElmer) and the cAMP levels are expressed as a ratio of 665/620 nm and shown in FIGS. 2A-2E and Figure.

Example 5

Materials and Methods for Bispecific-Mouse In Vivo

Diabetic mice were selected primarily to screen for GLP-1 activity of the bispecific molecules. Molecules were selected based on their potential to reduce plasma glucose levels at different time points post injection. In addition, body weight loss or inhibition of body weight gain was also measured indicative of GLP-1 activity, GIPR inhibition, or a combination of both, either from co-administration of each or from the bispecific molecule as shown in FIGS. 4A-4I. Male db/db mice (#642) were obtained from Jackson Laboratories (Bar Harbor, Me.) and delivered at 8-9 weeks of age. Upon arrival, mice were group-housed at four per cage and maintained in controlled environmental conditions with 12 hour light (6:30 AM-6:30 PM) and dark cycles (6:30 PM-6:30 AM). Mice were fed a standard rodent chow diet (2020× Harlan Teklad) with free-access to drinking water.

In other studies, glucose tolerance test was used to rank the potency of GLP-1 analogs (FIGS. 5A-5C). C57B16 mice were acclimated to environment conditions for one to two weeks. Prior to dosing, mice were handled and body weight measurements were taken. One day prior to dosing, conscious mice were bled from the retro-orbital sinus for plasma glucose measurement using a handheld glucometer designed for rodent plasma. On the day of dosing, baseline plasma glucose and body weight measurements were taken. The cage mean for plasma glucose and body weight were used to stratify cages into treatment groups. Mice were maintained in their home cages. Following administration of test article, plasma glucose was measured at various time points at (1, 3, and 6 hr) or (4 hr) and plasma glucose and body weight measurements were taken every 24 hrs thereafter. Plasma glucose levels were measured until levels returned to near baseline levels and body weight measurements were taken until the rate of body weight gain was similar to Vehicle-treated control group.

Diet-induced obese mice (DIO) were also used as a model to measure weight loss effects from treatment with different molecules as shown in FIG. 6.

Male c57bl6 mice were obtained from Harlan Laboratories and delivered at 26 days of age. Mice were group-housed with littermates consisting between two to four mice per cage. Following one week of acclimation, mice were started on a feeding regimen of high-fat diet (HFD: D12492, Research Diets, New Brunswick, N.J.) or continued on standard rodent diet (2020×, Harlan Laboratories). After 12 weeks of feeding, single-housed mice were acclimated to routine handling, food intake measurement, and daily saline injections (IP). Blood was collected from the retro orbital sinus of conscious DIO mice. A small volume of blood was immediately placed on a handheld glucometer designed for rodent plasma and the remaining blood was placed in EDTA filled collection tubes with a protease-inhibitor cocktail (Roche Diagnostics, Indianapolis, Ind.). Following centrifugation, plasma was stored at −80 C. Mice were stratified into treatment groups based on body weight, and plasma glucose measurements. Mice were treated with Vehicle (Q3D), GIPR Ab (2.5 or 10 mg/kg, Q3D), GLP-1 Peptide (0.06 mg/kg, QD), Dulaglutide (1 mg/kg, Q3D), or bispecific conjugate (2.5 or 10 mg/kg, Q3D). 2 additional groups of mice received a combination treatment of GLP-1 and GIPR Ab with the above dosage and dose frequency (GIPR 2.5 mg/kg+GLP-1 Peptide and GIPR 2.5 mg/kg+Dulaglutide). Aside from the GLP-1 Peptide dosed groups, all other mice were injected with saline when not dosed with their respective test article. Body weight was measured daily and cumulative food intake over three days was averaged for a daily food intake value. Food intake was measured between study days 0-3 and days 6-9. A blood collection was taken on study Day 9, 1 hour post injection and a terminal blood collection was taken on study Day 12, 1 or 3 days post the previous test article injection.

Plasma insulin was measured with a mouse ELISA kit following manufacturer's instructions (ALPCO, Salem, N.H.). Plasma glucose, cholesterol, triglyceride, non-esterified fatty acids, AST, and ALT were measured using an Olympus AU400e Chemistry Analyzer (Olympus America, Center Valley, Pa.).

Example 6

Materials and Methods for Bispecific-Cyno In Vivo

Naive male spontaneously obese cynomolgus monkeys (age 9-14 years) were acclimated/trained to experimental procedures prior to study initiation and were sorted into 7 treatment groups with n=10 monkeys each with equal distribution among groups for all sorting parameters (body weight and blood chemistries). Monkeys were then injected once weekly for 6 weeks with vehicle or GLP-1R-GIPR conjugates (1264, 1273, 1248 or 1257). After the 6 week treatment period, monkeys went through a 4 week washout phase. During training/treatment/washout phases of study, total energy intake was monitored daily; body weight, blood chemistries and drug exposure were monitored weekly or every other week as shown in FIGS. 7-21.

Example 7

Materials and Methods for GIP and GLP-1 Radioligand Competition Binding Assay

Membranes were prepared from mammalian cell lines overexpressing hu GIPR and hu GLP-1R and were typically stored at −80° C. in Assay Buffer: 50 mM HEPES (7.4), 5 mM MgCl₂, 1 mM CaCl₂, 0.2% BSA and Protease Inhibitor Tablets “EDTA Free”. Unlabeled GIP and GLP-1 peptides were obtained from Phoenix Pharmaceuticals and Radiolabeled ¹²⁵I-GIP and ¹²⁵I-GLP-1 were ordered from Perkin Elmer. Primary reactions were conducted for 2 h at room temperature with shaking in 96 well cell culture round bottom plates (Costar). Cell membrane concentration was fixed at 0.6 mg/mL and radioligands were used at a concentration of 0.1 nM. Test articles were titrated at six concentrations in duplicate. The primary plate was harvested after two hours with ice cold 50 mM TRIS (pH 7.4) using a Filtermate Harvester (Perkin Elmer) and cell membranes were captured on PEI-treated GF/C UniFilter plates (Perkin Elmer). Plates were dried for 15 min using a vacuum oven and Microscint 20 was added to each well before counting in a Perkin Elmer TopCount NXT HTS instrument. Specific binding was determined by taking the difference of total and non-specific counts. Non-specific wells contained 1 μM cold ligand. Data was analyzed and plotted using GraphPad Prism 7 as shown in FIG. 22.

Example 8

Internalization Assay

GLP-1R and GIPR internalization were assessed in CHOK1 cells expressing both human GLP-1R and GIPR. Cells were plated at a density of 25,000 cells/well in 96 well plates and cultured overnight at 37° C., 5% CO₂. Cells were serum starved in F12 media (Thermo Fisher) with 0.1% BSA for 4 hours prior to treatment. Cells were treated with 20 nM or dose titrations of GLP-1, GIP or bispecific conjugates for 30 minutes or the specified time in the respective figures. Cells were washed and fixed with 4% formaldehyde and permeabilized with 0.1% triton-X 100. To detect GIPR or GLP-1R, cells were first blocked with Odyssey blocking buffer (LiCor) for 1 hour at room temperature and incubated with 2 μg/ml of mouse anti-human GLP-1R (R&D systems) or 5 μg/ml of anti-human GIPR antibody (R&D Systems) at 4° C. overnight followed by AlexaFluor-555 or Alexa-Fluor 647 conjugated anti-mouse secondary antibody (Thermo Fisher) for GLP-1R or GIPR detection, respectively. Images (FIG. 23) were captured using Operetta high content Imaging system (Perkin Elmer) and analyzed by using the Harmony software (Perkin Elmer) to quantify the intracellular GLP-1R content (total spot area) as the readout parameter for the degree of internalization (FIG. 24).

Example 9

GLP-1R, GIPR and Bispecific Conjugate are Co-Localized Upon Internalization

U2OS cells expressing GIPR and SNAP-GLP-1R were plated at a density of 15,000 cells per well in 96 well plate and cultured overnight at 37° C. with 5% CO₂. Prior to treatment, cells were starved for 3.5 hours in McCoy's 5A media (Thermo Fisher) with 0.1% BSA. Prior to treatment, GLP-1R on the surface of U2OS cells were labeled with Alexa-Fluor 564 by incubating with SNAP-Surface Alexa-fluor 564 substrate (New England Biolabs) for 30 minutes. Cells were then washed to remove excess label and treated with 5 nM bispecific conjugates for 30 minutes. After 3 washes, cells were fixed with 4% formaldehyde and permeabilized with 0.1% triton-X 100 in PBS. For GIPR detection, cells were first blocked with Odyssey blocking buffer (LiCor) for 1 hour at room temperature and then incubated with 5 μg/ml of mouse anti-human GIPR (R&D Systems) at 4° C. overnight followed by incubation with Alexa-Fluor 647 conjugated anti-mouse secondary antibody (Thermo Fisher) for 1 hour at room temperature. Bispecific conjugate was detected using Alexa-Fluor labeled anti-Human Fc antibody. Hoechst 33342 were used for nuclei detection (Thermo Fisher). Images were captured using Operetta CLS high content Imaging system (Perkin Elmer) as shown in FIG. 25.

Example 10

GloSensor cAMP Assay

The GloSensor cAMP assay was conducted per manufacturer's protocol (Promega). In brief, ChoK1 human GLP-1R/GIPR-expressing cells were seeded at 15,000 cells per well in a 96 well plate and incubated for 16 hours in a humidified 37° C., 5% CO₂ incubator. Cells were transiently transfected with 100 ng pGloSensor −22F cAMP plasmid using FuGENE HD for 24 hours. Cells were then equilibrated with 0.1% BSA, 2% GloSensor cAMP reagent in CO₂ independent media (Invitrogen) for 2 hours at room temperature. Cells were preincubated for 15 min with or without 0.43 M sucrose (Sigma). Basal luminescence measurements were taken for 10 minutes prior to addition of 1248 in conditions with or without sucrose. Immediately following addition of 1248, kinetic luminescence was measured using an integration time of 0.1-1 second every 60 seconds. Data were analyzed using GraphPad Prism software and presented in FIG. 26.

Example 11

FACS Analysis

CHOK1-GLP-1R H20, 293T-GIPR clone 10 and CHOK1-GLP-1R/GIPR cells were suspended at a density of 1×10⁶ cells in 100 ul of F12 assay media containing 1% FBS, 0.05% sodium azide and incubated with 10 ug/ml of indicated antibodies or anti-GIPR/GLP-1R bispecific conjugates for 1 hr at 4° C. Cells were washed one time with assay buffer and then incubated with 10 ug/ml of Alexa Fluor 647-goat anti-human Fc (Jackson) for 30 min at 4° C. The Fluorescence was measured using BD LSR II Flow Cytometer (BD Biosciences) and shown in FIG. 27.

Example 12

Calcium Flux Assay

CHOK1 cells expressing GIPR and GLP-1-R were plated at a density of 30,000 cells per well in 96 well black clear bottom plate and cultured overnight at 37° C. with 5% CO₂. Cells were serum starved in F12 media (Thermo Fisher) with 20 mM HEPES for 2 hours. Cells were then loaded with buffer containing the calcium-sensitive dye (BD Biosciences) and incubated for 1 hour at room temperature before being treated with dose titrations of GLP-1 or bispecific conjugates. Changes in intracellular calcium content were monitored for using a FLIPR (Molecular Devices). Maximum peak height in each well was recorded as representing calcium influx as shown in FIG. 28.

Example 13

Beta-Arrestin Assay

CHOK1 Pathhunter cells expressing ProLink™ tagged GLP-1R and GIPR from DiscoverX were transfected with un-tagged GIPR or GLP-1R, respectively. Cells were plated at a density of 20,000 cells per well in assay media (F12/0.1% BSA) and incubated at 37° C. overnight. Cells were treated with dose titrations of GLP-1, GIP or bispecific conjugates for 90 minutes. The working detection solution (DiscoverX) were then added to the cells and incubated for 60 min at room temp in the dark. Chemiluminescent signal representing beta-arrestin recruitments were measured using Envision and shown in FIG. 29.

Example 14

Human Pancreatic Islet Microtissues Glucose Stimulated Insulin Secretion (GSIS) Assay

Human pancreatic islet microtissues were purchased from InSphero in 96 well format. Microtissues were incubated for 16 hours in InSphero assay media. They were then treated for 1 hour with fresh KREBS buffer (129 mM NaCl, 4.8 mM KCl, 1.2 mM KH₂PO₄, 1.2 mM MgSO₄-7H₂O, 10 mM HEPES, 1.3 mM CaCl₂, 0.5% BSA, pH 7.4) with 2.8 mM glucose. Following 2 KREBS buffer washes, they were then incubated with KREBS buffer alone, 2.8 mM or 11 mM glucose in KREBS buffer with or without GLP-1(Phoenix Pharmaceuticals) and a dose response of 1248 for 16 hours. Supernatant was collected and analyzed for insulin secretion according to manufacturer's protocol (Mercodia). Optical density was read at 450 nm on a TECAN microplate reader and shown in FIG. 30. 

What is claimed is:
 1. A composition comprising a) an antibody or functional fragment thereof that specifically binds to human GIPR, wherein said antibody comprises a CDRL1, a CDRL2, a CDRL3, a CDRH1, a CDRH2, and a CDRH3, wherein each CDRL1, CDRL2, CDRL3, CDRH1, CDRH2, and CDRH3, respectively, comprise SEQ ID NO: 702, SEQ ID NO: 859, SEQ ID NO: 1016, SEQ ID NO: 1173, SEQ ID NO: 1330, and SEQ ID NO: 1487; and wherein the antibody or functional fragment thereof comprises a cysteine or non-canonical amino acid amino acid substitution at one or more conjugation site(s); and b) a GLP-1 receptor agonist, wherein the GLP-1 receptor agonist is conjugated to the antibody or functional fragment thereof through the side-chain of the cysteine residue or non-canonical amino acid residue substituted at the one or more conjugation site(s).
 2. The composition of claim 1, wherein said human GIPR has a sequence comprising a sequence selected from the group consisting of SEQ ID NO: 3141, SEQ ID NO: 3143, and SEQ ID NO:
 3145. 3. The composition of claim 1, wherein said antibody or functional fragment thereof is a monoclonal antibody, a recombinant antibody, a human antibody, a humanized antibody, a chimeric antibody, a multispecific antibody, or an antibody fragment thereof.
 4. The composition of claim 3, wherein said antibody fragment is a Fab fragment, a Fab′ fragment, or a F(ab′)2 fragment.
 5. The composition of claim 3, wherein said antibody or functional fragment thereof is a human antibody.
 6. The composition of claim 3, wherein said antibody or functional fragment thereof is a monoclonal antibody.
 7. The composition of claim 3, wherein said antibody or functional fragment thereof is of the IgG1-, IgG2- IgG3- or IgG4-type.
 8. The composition of claim 7, wherein said antibody or functional fragment thereof is of the IgG1- or the IgG2-type.
 9. The composition of one of claim 3, wherein said antibody or functional fragment thereof inhibits binding of GIP to the extracellular portion of human GIPR.
 10. The composition of claim 3, wherein said antibody or functional fragment thereof is an antibody, and wherein said antibody comprises a combination of a light chain and a heavy chain, wherein the the light chain comprises the amino acid sequence of SEQ ID NO: 338 and the heavy chain comprises the amino acid sequence of SEQ ID NO: 545, wherein the antibody or functional fragment thereof comprises a cysteine or non-canonical amino acid amino acid substitution at one or more conjugation site(s) selected from the group consisting of D70 of the antibody light chain relative to reference sequence SEQ ID NO: 455, E276 of the antibody heavy chain relative to reference sequence SEQ ID NO: 612, and T363 of the antibody heavy chain relative to reference sequence SEQ ID NO:
 612. 11. The composition of claim 1, wherein the antibody or functional fragment thereof comprises a cysteine or non-canonical amino acid amino acid substitution at one or more conjugation site(s) selected from the group consisting of D70 of the antibody light chain relative to reference sequence SEQ ID NO: 455, E276 of the antibody heavy chain relative to reference sequence SEQ ID NO: 612, and T363 of the antibody heavy chain relative to reference sequence SEQ ID NO:
 612. 12. The composition of claim 1, wherein said antibody or functional fragment thereof comprises a combination of a light chain variable region and a heavy chain variable region, wherein the light chain variable region comprises the amino acid sequence of SEQ ID NO: 74 and the heavy chain variable region comprises the amino acid sequence of SEQ ID NO:
 231. 13. The composition of claim 12, wherein the antibody or functional fragment thereof comprises a cysteine or non-canonical amino acid amino acid substitution at one or more conjugation site(s) selected from the group consisting of D70 of the antibody light chain relative to reference sequence SEQ ID NO: 455, E276 of the antibody heavy chain relative to reference sequence SEQ ID NO: 612, and T363 of the antibody heavy chain relative to reference sequence SEQ ID NO:
 612. 14. The composition of any one of claims 1-11 and 12, 13, 10, wherein the GLP-1 receptor agonist is GLP-1(7-37) or a GLP-1(7-37) analog.
 15. The composition of claim 14, wherein receptor agonist or GLP-1(7-37) analog is selected from the group consisting of GLP-1(7-37) (SEQ ID NO: 3184); GLP-1(7-36)-NH₂(SEQ ID NO: 3185); liraglutide; albiglutide; taspoglutide; dulaglutide, semaglutide; LY2428757; Exendin-4 (SEQ ID NO: 3163); Exendin-3 (SEQ ID NO: 3164); Leu¹⁴-exendin-4 (SEQ ID NO: 3165); Leu¹⁴,Phe²⁵-exendin-4 (SEQ ID NO: 3166); Leu¹⁴,Ala¹⁹,Phe²⁵-exendin-4 (SEQ ID NO: 3167); exendin-4(1-30) (SEQ ID NO: 3168); Leu¹⁴-exendin-4(1-30) (SEQ ID NO: 3169); Leu¹⁴,Phe²⁵-exendin-4(1-30) (SEQ ID NO: 3170); Leu¹⁴,Ala¹⁹,Phe²⁵-exendin-4(1-30) (SEQ ID NO: 3171); exendin-4(1-28) (SEQ ID NO: 3172); Leu¹⁴-exendin-4(1-28) (SEQ ID NO: 3173); Leu¹⁴,Phe²⁵-exendin-4(1-28) (SEQ ID NO: 3174); Leu¹⁴,Ala¹⁹,Phe²⁵-exendin-4 (1-28) (SEQ ID NO: 3175); Leu¹⁴,Lys^(17,20),Ala¹⁹,Glu²¹,Phe⁵,Gln²⁸-exendin-4 (SEQ ID NO: 3176); Leu¹⁴,Lys^(17,20),Ala¹⁹,Glu²¹,Gln²⁸-exendin-4 (SEQ ID NO: 3177); octylGly¹⁴,Gln²⁸-exendin-4 (SEQ ID NO: 3178); Leu¹⁴,Gln²⁸,octylGly³⁴-exendin-4 (SEQ ID NO: 3179); Phe⁴,Leu¹⁴,Gln²⁸,Lys³³,Glu³⁴, Ile^(35,36),Ser³⁷-exendin-4(1-37) (SEQ ID NO: 3180); Phe⁴,Leu¹⁴,Lys^(17,20),Ala¹⁹,Glu²¹,Gln²⁸-exendin-4 (SEQ ID NO: 3181); Val¹¹,Ile¹³,Leu¹⁴,Ala¹⁶,Lys²¹,Phe²⁵-exendin-4 (SEQ ID NO: 3182); exendin-4-Lys⁴⁰ (SEQ ID NO: 3183); GLP-1(7-37) (SEQ ID NO: 3184); GLP-1(7-36)-NH₂ (SEQ ID NO: 3185); Aib^(8,35),Arg^(26,34),Phe³¹-GLP-1(7-36)) (SEQ ID NO: 3186); HXaa₈EGTFTSDVSSYLEXaa₂₂Xaa₂₃AAKEFIXaa₃₀WLXaa₃₃Xaa₃₄G Xaa₃₆Xaa₃₇; wherein Xaa₈ is A, V, or G, Xaa₂₂ is G, K, or E; Xaa₂₃ is Q or K; Xaa₃₀ is A or E; Xaa₃₃ is V or K Xaa₃₄ is K, N, or R; Xaa₃₆ is R or G; and Xaa₃₇ is G, H, P, or absent (SEQ ID NO: 3187); Arg³⁴-GLP-1(7-37) (SEQ ID NO: 3188); Glu³⁰-GLP-1(7-37) (SEQ ID NO: 3189); Lys²²-GLP-1(7-37) (SEQ ID NO: 3190); Gly^(8,36),Glu²²-GLP-1(7-37) (SEQ ID NO: 3191); Val⁸,Glu²²,Gly³⁶-GLP-1(7-37) (SEQ ID NO: 3192); Gly^(8,36),Glu²²,Lys³³,Asn³⁴-GLP-(7-37) (SEQ ID NO: 3193); Val⁸,Glu²²,Lys³³,Asn³⁴,Gly³⁶-GLP-1(7-37) (SEQ ID NO: 3194); Gly^(8,36),Glu²²,Pro³⁷-GLP-1(7-37) (SEQ ID NO: 3195); Val⁸,Glu²²,Gly³⁶,Pro³⁷-GLP-1(7-37) (SEQ ID NO: 3196); Gly^(8,36),Glu²²,Lys³³, Asn³⁴,Pro³⁷-GLP-1(7-37) (SEQ ID NO: 3197); Val⁸,Glu²²,Lys³³,Asn³⁴,Gly³⁶,Pro³⁷-GLP-1(7-37) (SEQ ID NO: 3198); Gly^(8,36),Glu²²-GLP-1(7-36) (SEQ ID NO: 3199); Val⁸,Glu²²,Gly³⁶-GLP-1(7-36) (SEQ ID NO: 3200); Val⁸,Glu²²,Asn³⁴,Gly³⁶-GLP-1(7-36) (SEQ ID NO: 3201); Gly^(8,36),Glu²²,Asn³⁴-GLP-1(7-36) (SEQ ID NO: 3202); GLP-1 analog (SEQ ID NO: 3206); GLP-1 analog (SEQ ID NO: 3207); [N^(e)-(17-carboxyheptadecanoic acid)Lys²⁰]exendin-4-NH₂(SEQ ID NO: 3208); [N^(e)-(17-carboxyhepta-decanoyl)Lys³²]exendin-4-NH₂(SEQ ID NO: 3209); [desamino-His¹,N^(e)-(17-carboxyheptadecanoyl)Lys²⁰]exendin-4-NH₂(SEQ ID NO: 3210); [Arg^(12,27),NLe¹⁴,N^(e)-(17-carboxy-heptadecanoyl)Lys³²]exendin-4-NH₂ (SEQ ID NO: 3211); [N^(e)-(19-carboxy-nonadecanoylamino)Lys²⁰]-exendin-4-NH₂(SEQ ID NO: 3212); [N^(e)-(15-carboxypentadecanoylamino)Lys²⁰]-exendin-4-NH₂ (SEQ ID NO: 3213); [N^(e)-(13-carboxytridecanoylamino)Lys²⁰]exendin-4-NH₂(SEQ ID NO: 3214); [N^(e)-(11-carboxy-undecanoyl-amino)Lys²⁰]exendin-4-NH₂(SEQ ID NO: 3215); exendin-4-Lys⁴⁰(e-MPA)-NH₂ (SEQ ID NO: 3216); exendin-4-Lys⁴⁰(e-AEEA-AEEA-MPA)-NH₂(SEQ ID NO: 3217); exendin-4-Lys⁴⁰(e-AEEA-MPA)-NH₂(SEQ ID NO: 3218); exendin-4-Lys⁴⁰(e-MPA)-albumin (SEQ ID NO: 3219); exendin-4-Lys⁴⁰(e-AEEA-AEEA-MPA)-albumin (SEQ ID NO: 3220); exendin-4-Lys⁴⁰(e-AEEA-MPA)-albumin (SEQ ID NO: 3221); desamino-His⁷Arg²⁶,Lys³⁴(N^(ε)-(γ-Glu(N-α-hexadecanoyl)))-GLP-1(7-37) (core peptide disclosed as SEQ ID NO: 3222) (SEQ ID NO: 3222); desamino-His⁷,Arg²⁶,Lys³⁴(N^(ε)-octanoyl)-GLP-1(7-37) (SEQ ID NO: 3223); Arg^(26,34),Lys³⁸(N^(ε)-(ω-carboxypentadecanoyl))-GLP-1(7-38) (SEQ ID NO: 3224); Arg^(26,34),Lys³⁶(N^(ε)-(γ-Glu(N-α-hexadecanoyl)))-GLP-1(7-36) (core peptide disclosed as SEQ ID NO: 3225) (SEQ ID NO: 3225); [Aib⁸;Lys³⁷]GLP-1_(7-37) (SEQ ID NO: 3226); [Aib⁸, Lys²⁶]GLP-1_(7-37) (SEQ ID NO: 3227); [Aib^(8,22);Lys³⁶]GLP-1(7-36)-Amide (SEQ ID NO: 3228); [Aib^(8,22);BLeu³²;Lys³⁶]GLP-1(7-36)-Amide (SEQ ID NO: 3229); [Aib^(8,22);Lys³⁷]GLP-1(7-37)-Amide (SEQ ID NO: 3230); [Aib^(8,22);BLeu³²;Lys³⁷]GLP-(7-37)-Amide (SEQ ID NO: 3231); [Aib^(8,22);aMeLeu³²;Lys³⁷]GLP-1(7-37)-Amide (SEQ ID NO: 3232); [Aib^(8,22);AMEF¹²;Lys³⁷]GLP-1(7-37)-Amide (SEQ ID NO: 3233); [Aib^(8,22);BLeu¹⁶;Lys³⁷]GLP-1(7-37)-Amide (SEQ ID NO: 3234); [Aib^(8,22);Gly³⁶;Lys³⁷]GLP-1(7-37)-Amide (SEQ ID NO: 3235); [Aib^(8,22);Lys^(33,37);Asn³⁴;Gly³⁶]GLP-1(7-37)-Amide (SEQ ID NO: 3236); [Aib^(8,22);Lys³³;Asn³⁴;Gly³⁶;Aeea³⁷]GLP-(7-37)-Aeea-Lys-Amide (SEQ ID NO: 3237); [Aib^(8,22);Gly³⁶]GLP-1(7-37) (SEQ ID NO: 3238); cyclo[E²³-K²⁷][Aib⁸;Gly¹⁶]GLP-1(7-37) (SEQ ID NO: 3239); cyclo[E K26][Aib⁸;Gly³⁶;Lys³⁷]GLP-4(7-37)-Amide (SEQ ID NO: 3240); [Aib^(8,22)]-GLP-1(7-22)-Ex4(17-39) (SEQ ID NO: 3241); [Gly^(8,36);Glu²²]GLP-1(7-37) (SEQ ID NO: 3242); [Aib⁸;Glu²²;Gly³⁶]GLP-1(7-37)-Amide (SEQ ID NO: 3243); [Aib⁸;Tyr¹⁶;Glu²²;Gly³⁶]GLP-1_(7-37) (SEQ ID NO: 3244); [Aib⁸;Lys^(18,33);Glu^(22,23,30)Val²⁵;Arg²⁶;Leu²⁷;Asn³⁴;Gly³⁶]GLP-1(7-37) (SEQ ID NO: 3245); [Aib⁸;Lys^(18,33);Glu^(22,23,30);Leu²⁷;Asn³⁴;Gly³⁶]GLP-1(7-37) (SEQ ID NO: 3246); [Aib⁸;Lys¹⁸;Glu^(22,23,30);Leu²⁷;Gly³⁶]GLP-1(7-37) (SEQ ID NO: 3247); [Aib²²;Ile⁹;Gly³⁶]GLP-1_(7-36) (SEQ ID NO: 3248); and [Aib^(8,22);Glu¹⁵;Gly³⁶]GLP-1_(7-36) (SEQ ID NO: 3249).
 16. The composition of claim 14, wherein the GLP-1(7-37) or GLP-1(7-37) analog is conjugated to the antibody or fragment thereof at a residue that corresponds to K26, K36, K37, K39 or a C-terminal amine group of said analog.
 17. The composition of any one of claims 1-11 and 12, 13, 10, wherein the GLP-1 receptor agonist is selected from the group consisting of exenatide, liraglutide, lixisenatide, albiglutide, dulaglutide, semaglutide, and taspoglutide.
 18. The composition of claim 1, wherein the GLP-1 receptor agonist if conjugated to the antibody or fragment thereof via a peptide linker comprising a sequence selected from the group consisting of (Gly₃Ser)₂, (Gly₄Ser)₂, (Gly₃Ser)₃, (Gly₄Ser)₃, (Gly₃Ser)₄, (Gly₄Ser)₄, (Gly₃Ser)₅, (Gly₄Ser)₅, (Gly₃Ser)₆, and (Gly₄Ser)₆. 